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[PMID]:29287881
[Au] Autor:Ünsaler S; Basaran B; Aslan I; Yilmazbayhan D
[Ad] Endereço:Department of Otolaryngology, Acibadem Altunizade Hospital, Üsküdar, Istanbul, 34662, Turkey. Electronic address: selinunsaler@gmail.com.
[Ti] Título:Endonasal endoscopic nasopharyngectomy for the treatment of nasopharyngeal papillary adenocarcinoma: Report of a rare case.
[So] Source:Int J Pediatr Otorhinolaryngol;104:51-53, 2018 Jan.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:We report a case of low-grade nasopharyngeal papillary adenocarcinoma in a 9 year-old male that was diagnosed incidentally after an adenoidectomy procedure and treated with endonasal endoscopic nasopharyngectomy without any adjuvant therapy. The patient has been followed up for 3 years with no evidence of recurrence. We point out the importance of preoperative fiberoptic nasopharyngoscopy in the absence of longstanding symptoms in school-aged children and histopathologic examination of adenoidectomy specimens in the presence of atypical findings. We also suggest endonasal endoscopic resection in case of papillary adenocarcinoma.
[Mh] Termos MeSH primário: Adenocarcinoma Papilar/cirurgia
Carcinoma/cirurgia
Endoscopia/métodos
Neoplasias Nasofaríngeas/cirurgia
Faringectomia/métodos
[Mh] Termos MeSH secundário: Adenoidectomia
Criança
Seres Humanos
Masculino
Procedimentos Cirúrgicos Nasais/métodos
Nariz/patologia
Nariz/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171231
[St] Status:MEDLINE


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[PMID]:28452703
[Au] Autor:Shin JM; Park JH; Kim HJ; Park IH; Lee HM
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Seoul, South Korea.
[Ti] Título:Cigarette smoke extract increases vascular endothelial growth factor production TLR4/ROS/MAPKs/NF-kappaB pathway in nasal fibroblast.
[So] Source:Am J Rhinol Allergy;31(2):78-84, 2017 Mar 01.
[Is] ISSN:1945-8932
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Cigarette smoke is a complex mixture of various chemical compounds, including free radicals and highly toxic compounds. Cigarette smoke exposure has been shown to be associated with chronic rhinosinusitis and tissue remodeling in upper airway. Vascular endothelial growth factor (VEGF) is one of the cytokines with a crucial role in tissue remodeling of airway. The aims of this study were to determine the effects of cigarette smoke extract (CSE) on VEGF expression and to investigate the underlying molecular mechanisms of CSE in nasal fibroblasts. METHODS: Nasal fibroblasts were stimulated with CSE. Cytotoxicity was evaluated by 3-(4,5- dimethylthiazol-2yl)-2,5-diphenyl-tetrazolium bromide assay. The expression level of VEGF was measured using reverse transcription-polymerase chain reaction (RT-PCR), and enzyme-linked immunosorbent assay. Messenger RNA (mRNA) expression level of TLR4 were determined by RT-PCR. Small interfering RNA (siRNA) for TLR4 was transfected to suppress TLR4 expression. Activation of reactive oxygen species (ROS) was analyzed by using dichloro-dihydro-fluorescein diacetate assay. Mitogen-activated protein kinase (MAPK) and NF-kappaB activations were determined by using western blot and/or luciferase assay. RESULTS: CSE had no significant cytotoxic effect in nasal fibroblast up to 5%. CSE significantly increased both VEGF mRNA and protein expression dose-dependently. The down-regulation of TLR4 transcription by siRNA treatment suppressed CSE-induced expressions of both TLR4 and VEGF. Pretreatment with ROS scavengers, specific inhibitors of each MAPK, and NF-kappaB inhibitor significantly decreased CSE-induced VEGF expression. CONCLUSIONS: CSE has a stimulatory effect on VEGF expression through the TLR4, ROS, MAPK, and NF-kappaB signaling pathway in nasal fibroblasts.
[Mh] Termos MeSH primário: Fibroblastos/fisiologia
Nariz/patologia
Receptor 4 Toll-Like/metabolismo
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Mh] Termos MeSH secundário: Adulto
Morte Celular
Células Cultivadas
Fumar Cigarros/efeitos adversos
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Feminino
Regulação da Expressão Gênica
Seres Humanos
Masculino
NF-kappa B/metabolismo
RNA Interferente Pequeno/genética
Espécies Reativas de Oxigênio/metabolismo
Transdução de Sinais
Receptor 4 Toll-Like/genética
Fator A de Crescimento do Endotélio Vascular/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NF-kappa B); 0 (RNA, Small Interfering); 0 (Reactive Oxygen Species); 0 (TLR4 protein, human); 0 (Toll-Like Receptor 4); 0 (Vascular Endothelial Growth Factor A); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.2500/ajra.2017.31.4415


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[PMID]:29429183
[Au] Autor:Fu T; Zhang K; Zhang XW; Wang ZY
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Hospital of Qingdao University, Qingdao 266003, China.
[Ti] Título:[Correlation between patulous Eustachian tube with habitual nasal extraction and acquired middle ear cholesteatoma].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(2):131-133, 2018 Feb 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:By comparing the clinical characteristics of patulous Eustachian tube with habitual nasal extraction and those of non-Eustachian tube abnormalities, we aimed to investigate the relationship between patulous Eustachian tube and acquired cholesteatoma of middle ear. A total of 218 patients in Affiliated Hospital of Qingdao University from November 2011 to November 2016 who underwent surgical treatment and with complete data of acquired cholesteatoma of middle ear were enrolled. The patients were divided into two groups: patulous Eustachian tube with habitual nasal extraction and non-Patulous Eustachian tube. Their ages of onset , sides, characteristics of acoustic immitance, clinical manifestations, prognosis and complications were compared. The statistical analysis was carried out with SPSS 19.0 software. Among the 218 cases of acquired cholesteatoma of the middle ear, 22 cases were diagnosed as patulous Eustachian tube with habitual nasal extraction [with average age of (35.7±7.5) years]; 196 cases were diagnosed as non-patulous Eustachian tube [with average age of (47.8±20.1) years]. The average age of the patulous Eustachian tube with habitual nasal extraction was significantly lower than that of the non-patulous Eustachian tube group ( =4.25, <0.01). Ratio of bilateral middle ear cholesteatoma in patulous Eustachian tube [68.2%(15/22)] was significantly higher than that of the non-patulous Eustachian tube group [18.9%(37/196)] (χ(2)=26.47, <0.01). Some acquired cholesteatoma patients are associated with the patulous Eustachian tube with habitual nasal extraction. The patients have a lower age, and are susceptible for bilateral middle ear cholesteatoma.
[Mh] Termos MeSH primário: Colesteatoma da Orelha Média/diagnóstico
Tuba Auditiva
[Mh] Termos MeSH secundário: Acústica
Adulto
Idade de Início
Colesteatoma da Orelha Média/etiologia
Seres Humanos
Nariz
Otite Média/diagnóstico
Prognóstico
Software
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.02.009


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[PMID]:28470359
[Au] Autor:Topuz MF; Sari M; Binnetoglu A; Dogrul R; Bugdayci O; Seker A
[Ad] Endereço:Department of Otorhinolaryngology, Dumlupinar University School of Medicine, Istiklal Parish Okmeydani st. No: 10 Merkez, Kütahya, Turkey. drfatihtopuz@yahoo.com.
[Ti] Título:Is endoscopic endonasal transsphenoidal surgery increases the susceptibility to rhinosinusitis.
[So] Source:Eur Arch Otorhinolaryngol;274(8):3065-3069, 2017 Aug.
[Is] ISSN:1434-4726
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to analyze whether the measurement of changes in the anatomical position and volume of middle concha, the volume changes in the area between the middle concha and lamina papyracea, the evaluation of opacification in major paranasal sinuses, and osteomeatal complex occlusion in cases with middle concha by out-fracture technique during endoscopic endonasal transsphenoidal approach is a minimally invasive surgery, and also to find out whether these changes lead to the development of tendency to rhinosinusitis. It was a retrospective clinical study. Forty-five cases, between 2013 and 2015, planned for endoscopic endonasal transsphenoidal surgery due to hypophyseal pathology at the Neurosurgery Departments of Marmara University Hospital were evaluated retrospectively. The patients were evaluated for the changes in the anatomy of the middle concha and the effects of these changes to paranasal sinuses by paranasal computed tomographies were studied at the preoperative second week and postoperative 12 month. The Lund-Mackay scoring system was used for the evaluation of opacification in the five major paranasal sinuses and occlusion of the osteomeatal complex in the pre- and postoperative period. The Lund-Mackay scoring system was used to analyze the paranasal computed tomography of the patients at the preoperative 2 weeks and postoperative first year. According to the Lund-Mackay scoring system, no significant difference was detected between the preoperative and postoperative opacification of paranasal sinuses (p > 0.05). Besides, there was also no significant difference between the preoperative and postoperative osteomeatal complex occlusion (p > 0.05). Considering the distance between middle concha and lamina papyracea following the out-fracture of the middle concha, a significant lateralization of 0.5 mm between the preoperative and postoperative period was observed (p < 0.05). In addition, a significant change was also detected in the volume of middle concha (p < 0.05). The volume of the area between the middle concha and lamina papyracea was decreased with a statistical significance (p < 0.05). The endoscopic endonasal transsphenoidal surgery causes some variations in the structures of the middle concha, paranasal sinuses, and OMC, but these changes do not lead to significant rhinologic pathologies.
[Mh] Termos MeSH primário: Cirurgia Endoscópica por Orifício Natural
Rinite/etiologia
Sinusite/etiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Suscetibilidade a Doenças
Feminino
Seres Humanos
Masculino
Meia-Idade
Cirurgia Endoscópica por Orifício Natural/efeitos adversos
Nariz
Seios Paranasais/diagnóstico por imagem
Doenças da Hipófise/cirurgia
Estudos Retrospectivos
Osso Esfenoide
Conchas Nasais/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1007/s00405-017-4598-4


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[PMID]:29232810
[Au] Autor:Zoli M; Milanese L; Faustini-Fustini M; Guaraldi F; Asioli S; Zenesini C; Righi A; Frank G; Pia Foschini M; Sturiale C; Pasquini E; Mazzatenta D
[Ad] Endereço:Center of Pituitary Tumors and Endoscopic Skull Base Surgery, Department of Neurosurgery, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy. Electronic address: matteozeta@libero.it.
[Ti] Título:In Reply to the Letter to the Editor Regarding "Endoscopic Endonasal Surgery for Pituitary Apoplexy: Evidence On a 75 Case-Series From a Tertiary Care Center".
[So] Source:World Neurosurg;109:502, 2018 01.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Apoplexia Hipofisária/cirurgia
Centros de Atenção Terciária
[Mh] Termos MeSH secundário: Endoscopia
Seres Humanos
Nariz
Neoplasias Hipofisárias/cirurgia
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:29178640
[Au] Autor:Sukalo M; Schäflein E; Schanze I; Everman DB; Rezaei N; Argente J; Lorda-Sanchez I; Deshpande C; Takahashi T; Kleger A; Zenker M
[Ad] Endereço:Institute of Human Genetics, University Hospital Magdeburg, Magdeburg, Germany.
[Ti] Título:Expanding the mutational spectrum in Johanson-Blizzard syndrome: identification of whole exon deletions and duplications in the UBR1 gene by multiplex ligation-dependent probe amplification analysis.
[So] Source:Mol Genet Genomic Med;5(6):774-780, 2017 11.
[Is] ISSN:2324-9269
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Johanson-Blizzard syndrome (JBS, MIM #243800) is a very rare autosomal recessive disorder characterized by exocrine pancreatic insufficiency, nasal wing hypoplasia, hypodontia, and other abnormalities. JBS is caused by mutations of the UBR1 gene (MIM *605981), encoding a ubiquitin ligase of the N-end rule pathway. METHODS: Molecular findings in a total of 65 unrelated patients with a clinical diagnosis of JBS who were previously screened for UBR1 mutations by Sanger sequencing were reviewed and cases lacking a disease-causing UBR1 mutation on either one or both alleles were included in this study. In order to discover mutations that are not detectable by Sanger sequencing, we designed a probe set for multiplex ligation-dependent probe amplification (MLPA) analysis of the UBR1 gene and analyzed the copy number status of all 47 UBR1 exons. RESULTS: Our previous studies using Sanger sequencing could detect mutations in 93.1% of 130 disease-associated UBR1 alleles. Six patients with a highly suggestive clinical diagnosis of JBS and unsolved genotype were included in this study. MLPA analysis detected six alleles harboring exon deletions/duplications, thereby raising the mutation detection rate in the entire cohort to 97.7% (127/130 alleles). CONCLUSION: We conclude that single or multi-exon deletions or duplications account for a substantial proportion of JBS-associated UBR1 mutations.
[Mh] Termos MeSH primário: Anus Imperfurado/genética
Displasia Ectodérmica/genética
Transtornos do Crescimento/genética
Perda Auditiva Neurossensorial/genética
Hipotireoidismo/genética
Deficiência Intelectual/genética
Nariz/anormalidades
Pancreatopatias/genética
Ubiquitina-Proteína Ligases/genética
[Mh] Termos MeSH secundário: Adulto
Alelos
Anus Imperfurado/diagnóstico
Sequência de Bases
Criança
Pré-Escolar
DNA/química
DNA/isolamento & purificação
DNA/metabolismo
Análise Mutacional de DNA
Displasia Ectodérmica/diagnóstico
Éxons
Feminino
Deleção de Genes
Duplicação Gênica
Genótipo
Transtornos do Crescimento/diagnóstico
Perda Auditiva Neurossensorial/diagnóstico
Seres Humanos
Hipotireoidismo/diagnóstico
Deficiência Intelectual/diagnóstico
Masculino
Reação em Cadeia da Polimerase Multiplex
Pancreatopatias/diagnóstico
Fenótipo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
9007-49-2 (DNA); EC 2.3.2.27 (UBR1 protein, human); EC 2.3.2.27 (Ubiquitin-Protein Ligases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE
[do] DOI:10.1002/mgg3.319


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[PMID]:29304069
[Au] Autor:Kwetkat A; Pfister W; Pansow D; Pletz MW; Sieber CC; Hoyer H
[Ad] Endereço:Department of Geriatric Medicine, Jena University Hospital, Jena, Thuringia, Germany.
[Ti] Título:Naso- and oropharyngeal bacterial carriage in nursing home residents: Impact of multimorbidity and functional impairment.
[So] Source:PLoS One;13(1):e0190716, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: From April 2013 to February 2014 we performed a multicentre prospective cross-sectional study in 541 German nursing home residents. We determined pharyngeal carriage of Streptococcus pneumoniae (primary objective) and other bacteria (secondary objective) in naso- and oropharyngeal swabs by culture-based standard procedures and explored the influence of multimorbidity and functional status on bacterial carriage. METHODS: Socio-demographic data, vaccination status, multimorbidity, nutrition and functional status defined by Comprehensive Geriatric Assessment were evaluated. We estimated carriage rates with 95% confidence intervals (CI) and explored potential risk factors by logistic regression analysis. RESULTS: Pneumococcal post-serotyping carriage rate was 0.8% (95%CI 0.2-1.9%; 4/526). Serotyping revealed serotypes 4, 7F, 23B and 23F and S. pseudopneumoniae in two other cases. Odds of carriage were higher in men (Odds ratio OR 5.3 (95%CI 0.9-29.4)), in malnourished residents (OR 4.6 (0.8-25.7)), residents living in shared rooms (OR 3.0 (0.5-16.5)) or having contact with schoolchildren (OR 2.0 (0.2-17.6)). The most frequent pathogen was Staphylococcus aureus (prevalence 29.5% (25.6-33.6%)) with meticillin-resistant Staphylococcus aureus prevalence of 1.1%. Gram-negative bacteria (GNB) were found in 22.5% (19.0-26.3%) with a prevalence of extended-spectrum beta lactamase (ESBL) producing bacteria of 0.8%. Odds of S. aureus carriage were higher for immobility (OR 1.84 (1.15-2.93)) and cognitive impairment (OR 1.54 (0.98-2.40)). Odds of GNB carriage were higher in residents with more severe comorbidity (OR 1.13 (1.00-1.28)) and malnutrition (OR 1.54 (0.81-2.91)). CONCLUSIONS: Given the observed data, at least long-term carriage of S. pneumoniae in nursing home residents seems to be rare and rather unlikely to cause nursing home acquired pneumonia. The low rate of colonization with multi drug resistant (MDR) bacteria confirms that nursing home residency is not a risk factor for MDR pneumonia in Germany. For individual risk assessment in this susceptible population, immobility and malnutrition should be considered as signs of functional impairment as well as comorbidity.
[Mh] Termos MeSH primário: Portador Sadio/epidemiologia
Portador Sadio/microbiologia
Nariz/microbiologia
Casas de Saúde
Orofaringe/microbiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Escherichia coli
Feminino
Alemanha
Seres Humanos
Modelos Logísticos
Masculino
Multimorbidade
Prevalência
Estudos Prospectivos
Fatores de Risco
Staphylococcus aureus
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190716


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[PMID]:28468673
[Au] Autor:Haddow AD; Nasar F; Schellhase CW; Moon RD; Padilla SL; Zeng X; Wollen-Roberts SE; Shamblin JD; Grimes EC; Zelko JM; Linthicum KJ; Bavari S; Pitt ML; Trefry JC
[Ad] Endereço:United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702, USA. andrew.d.haddow.ctr@mail.mil.
[Ti] Título:Low potential for mechanical transmission of Ebola virus via house flies (Musca domestica).
[So] Source:Parasit Vectors;10(1):218, 2017 May 03.
[Is] ISSN:1756-3305
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Ebola virus (EBOV) infection results in high morbidity and mortality and is primarily transmitted in communities by contact with infectious bodily fluids. While clinical and experimental evidence indicates that EBOV is transmitted via mucosal exposure, the ability of non-biting muscid flies to mechanically transmit EBOV following exposure to the face had not been assessed. RESULTS: To investigate this transmission route, house flies (Musca domestica Linnaeus) were used to deliver an EBOV/blood mixture to the ocular/nasal/oral facial mucosa of four cynomolgus macaques (Macaca fascicularis Raffles). Following exposure, macaques were monitored for evidence of infection through the conclusion of the study, days 57 and 58. We found no evidence of systemic infection in any of the exposed macaques. CONCLUSIONS: The results of this study indicate that there is a low potential for the mechanical transmission of EBOV via house flies - the conditions in this study were not sufficient to initiate infection.
[Mh] Termos MeSH primário: Ebolavirus/isolamento & purificação
Doença pelo Vírus Ebola/transmissão
Moscas Domésticas/virologia
Insetos Vetores/virologia
[Mh] Termos MeSH secundário: Animais
Olho/virologia
Face/virologia
Fezes/virologia
Doença pelo Vírus Ebola/sangue
Doença pelo Vírus Ebola/virologia
Macaca fascicularis
Mucosa Bucal/virologia
Membrana Mucosa/virologia
Nariz/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s13071-017-2149-x


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[PMID]:28468221
[Au] Autor:Senda D; Ando E; Orgun D; Horiguchi M; Arakawa A; Matsuda A; Mizuno H; Hayashi A
[Ad] Endereço:*Department of Plastic and Reconstructive Surgery †Department of Human Pathology, Juntendo University School of Medicine ‡Department of Urology, Tokyo Women's Medical University, Tokyo Japan.
[Ti] Título:The Rapid Development of Squamous Cell Carcinoma on the Nasal Dorsum of a Patient Receiving Immunosuppressive Therapy.
[So] Source:J Craniofac Surg;28(3):e277-e279, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The risk of cancer is significantly increased in patients undergoing renal transplant surgery than in the general population. In particular, skin cancer is the most commonly occurring cancer in these patients.A 34-year-old man underwent living renal transplantation for focal segmental glomerulosclerosis. After 18 months, he developed a lesion on the nasal dorsum, approximately 1 cm in size, and the lesion rapidly expanded to cover the entire dorsum.Owing to its rapid expansion, the lesion was suspected to be a malignant tumor and wide excision was planned.We removed the lesion with a 6-mm margin. Squamous cell carcinoma was diagnosed through intraoperative rapid pathological examination. The nasal bone and septum were invaded by the tumor and, as a result, the entire external nose was removed. The patient's nose was subsequently reconstructed using a free forearm flap for lining, iliac bone graft for the nasal frame, and a scalping forehead flap for skin coverage.Selective target radiotherapy was administered at the closest margin around the lesion, and the dosage of immunosuppressants was reduced.At >2 years postoperatively, the patient showed good cosmetic results with no relapse or metastasis of the tumor.We report the unusual case of a young man who developed a rapidly progressing squamous cell carcinoma on his nasal dorsum after 18 months of immunosuppression. Squamous cell carcinoma in organ transplant recipients may be more aggressive and may progress differently than in regular patients. Therefore, special attention is required for patients who take immunosuppressive drugs after renal transplant surgery.
[Mh] Termos MeSH primário: Carcinoma de Células Escamosas/patologia
Rejeição de Enxerto/tratamento farmacológico
Imunossupressão/efeitos adversos
Imunossupressores/uso terapêutico
Transplante de Rim
Neoplasias Nasais/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma de Células Escamosas/etiologia
Progressão da Doença
Retalhos de Tecido Biológico/patologia
Seres Humanos
Imunossupressores/efeitos adversos
Masculino
Meia-Idade
Nariz/patologia
Neoplasias Nasais/etiologia
Fatores de Tempo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunosuppressive Agents)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003548


  10 / 18053 MEDLINE  
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[PMID]:29280870
[Au] Autor:Rohrich RJ; Afrooz PN
[Ad] Endereço:Dallas, Texas From the Dallas Plastic Surgery Institute.
[Ti] Título:Components of the Hanging Columella: Strategies for Refinement.
[So] Source:Plast Reconstr Surg;141(1):46e-54e, 2018 01.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The columella is a significant factor in the aesthetic balance of the nose, particularly the lower one-third of the nose. Its position is dependent on the anatomical constituents of the columella, and neighboring anatomical structures. Six components of the hanging columella have been identified: the caudal septum, medial crura, columellar skin, membranous septum, anterior nasal spine, and depressor septi nasi muscle. Columellar refinement begins with a careful analysis and diagnosis of the contributing components, followed by surgical techniques to address these components individually. The cumulative effect of correction of individual components appropriately positions the columella and contributes significantly to the enhancement of nasal aesthetics. Refinement of the columella can be achieved through appropriately trimming the caudal septum; repositioning and reshaping the medial crura; excising redundant columellar skin, membranous septum, and nasal mucosa; appropriately contouring the anterior nasal spine; and dividing the depressor nasi septi nasi.
[Mh] Termos MeSH primário: Nariz/anatomia & histologia
Rinoplastia/métodos
[Mh] Termos MeSH secundário: Adulto
Estética
Feminino
Seres Humanos
Nariz/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003569



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