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  1 / 8317 MEDLINE  
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[PMID]:28459157
[Au] Autor:Ozer EK; Goktas MT; Kilinc I; Toker A; Bariskaner H; Ugurluoglu C; Iskit AB
[Ad] Endereço:a Department of Pharmacology, Faculty of Medicine, Selcuk University, Konya, Turkey.
[Ti] Título:Infliximab alleviates the mortality, mesenteric hypoperfusion, aortic dysfunction, and multiple organ damage in septic rats.
[So] Source:Can J Physiol Pharmacol;95(7):866-872, 2017 Jul.
[Is] ISSN:1205-7541
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:Tumor necrosis factor-alpha (TNF-α) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis. We investigated the effects of infliximab on survival, mesenteric artery blood flow (MBF), vascular reactivity, and oxidative and inflammatory injuries in cecal ligation and puncture (CLP)-induced sepsis. Wistar rats were divided into Sham, CLP, Sham+infliximab, and CLP+infliximab subgroups. Twenty-four hours before the operations, rats were injected intraperitoneally with infliximab (7 mg/kg) or vehicle (saline; 1 mL/kg). Twenty hours after the operations, MBF and phenylephrine responses of isolated aortic rings were measured. Tissue damages were examined biochemically and histopathologically. Furthermore, survival rates were monitored throughout 96 h. Infliximab improved survival, mesenteric perfusion, and aortic function after CLP. Increases of serum AST, ALT, LDH, BUN, Cr, and inflammatory cytokines (tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6) induced by CLP were blocked by infliximab. Infliximab prevented malondialdehyde elevations in septic liver, lung, spleen, and kidney tissues, as well as glutathione reductions in septic liver, spleen, and kidney tissues. Protective effects of infliximab on multiple organ damage were also observed histopathologically. Infliximab showed protective effects in sepsis due to its improvement effects on mesenteric perfusion, aortic function, and its anti-inflammatory and antioxidative effects.
[Mh] Termos MeSH primário: Aorta/efeitos dos fármacos
Circulação Sanguínea/efeitos dos fármacos
Infliximab/farmacologia
Mesentério/irrigação sanguínea
Insuficiência de Múltiplos Órgãos/complicações
Sepse/mortalidade
Sepse/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Aorta/fisiopatologia
Feminino
Interleucina-6/metabolismo
Contração Muscular/efeitos dos fármacos
Músculo Liso Vascular/efeitos dos fármacos
Músculo Liso Vascular/fisiopatologia
Ratos
Ratos Wistar
Sepse/complicações
Sepse/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); B72HH48FLU (Infliximab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1139/cjpp-2016-0628


  2 / 8317 MEDLINE  
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[PMID]:29279563
[Au] Autor:Miyao M; Takahashi T; Uchida E
[Ad] Endereço:Department of Pediatric Surgery, Nippon Medical School Musashi Kosugi Hospital.
[Ti] Título:A Case of Anomalous Congenital Band that Was Difficult to Differentiate from Omphalomesenteric Duct Anomaly.
[So] Source:J Nippon Med Sch;84(6):304-307, 2017.
[Is] ISSN:1347-3409
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Anomalous congenital band (ACB) is rare and difficult to identify preoperatively. Here we report a pediatric ACB case that was preoperatively suspected using computed tomography and was difficult to differentiate from omphalomesenteric duct anomaly. ACB should be considered in the differential diagnosis of acute abdomen.
[Mh] Termos MeSH primário: Anormalidades Múltiplas/diagnóstico
Íleo/anormalidades
Mesentério/anormalidades
Umbigo/anormalidades
Ducto Vitelino/anormalidades
[Mh] Termos MeSH secundário: Abdome Agudo/etiologia
Anormalidades Múltiplas/diagnóstico por imagem
Adolescente
Diagnóstico Diferencial
Seres Humanos
Masculino
Período Pré-Operatório
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1272/jnms.84.304


  3 / 8317 MEDLINE  
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[PMID]:29224568
[Au] Autor:Li A; Hu R; Zhou D; Li S; Huang D; Wei X; Cao Z
[Ad] Endereço:Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1095 JieFang Avenue, Wuhan, 430030, Hubei, China.
[Ti] Título:Internal herniation through lesser omentum hiatus and gastrocolic ligament with malrotation: a case report.
[So] Source:J Med Case Rep;11(1):344, 2017 Dec 11.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Internal herniation through lesser omentum hiatus and gastrocolic ligament with malrotation is extremely rare. This type of internal hernia has rarely been described before. Preoperative diagnosis is difficult and prone to misdiagnosis. CASE PRESENTATION: A 38-year-old Chinese woman was an emergency admission to our hospital with a sudden onset of acute epigastralgia for the past 14 hours. We made a presumptive diagnosis of gastrointestinal perforation and septic shock. Due to the acute onset and rapid progress, she received timely surgical treatment. During operation, we observed that her small intestine herniated into the hepatogastric ligament and ligamentum gastrocolicum hiatus accompanied with intestinal malrotation that resulted in internal hernia. We found a diverticulum of approximately 3.0 × 6.0 cm sited at a distance of 80 cm from the ileocecal intestine. We resected the strangulated intestinal loop and the diverticulum, performed an appendicectomy, and closed the ligamentous fissure. Postoperation, she recovered smoothly, without any complications, and was discharged on day 6. CONCLUSIONS: A case of internal hernia formation is quite rare; accurate preoperative diagnosis and timely surgery are essential because it can cause strangulation of the ileus. However, the incidence of this internal herniation is low and preoperative diagnosis is difficult. An accurate preoperative diagnosis of internal hernia is still a challenge.
[Mh] Termos MeSH primário: Hérnia
Herniorrafia/métodos
Volvo Intestinal/cirurgia
Intestino Delgado/cirurgia
Ligamentos/cirurgia
Mesentério/cirurgia
Omento/cirurgia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Intestino Delgado/diagnóstico por imagem
Radiografia Abdominal
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1471-4


  4 / 8317 MEDLINE  
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[PMID]:29199257
[Au] Autor:Yokota-Nakatsuma A
[Ad] Endereço:Laboratory of Immunology, Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University.
[Ti] Título:[Retinoic Acid Prevents Dendritic Cells from Inducing Novel Inflammatory T Cells That Produce Abundant Interleukin-13].
[So] Source:Yakugaku Zasshi;137(12):1491-1496, 2017.
[Is] ISSN:1347-5231
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:Vitamin A (VA) plays critical roles in gut homeostasis. Dendritic cells in mesenteric lymph nodes (MLN-DCs) can metabolize VA to retinoic acid (RA), thereby inducing gut-tropic lymphocytes and enhancing peripheral differentiation of regulatory T cells expressing forkhead box P3. We found that MLN-DCs from VA-deficient mice induced a distinct inflammatory T helper type 2 (Th2)-cell subset that produced abundant interleukin-13 (IL-13) and expressed receptors for homing to skin and inflammatory sites but not to the intestine. IL-6-neutralizing antibodies or RA abrogated the induction of this subset. On the other hand, RA receptor antagonists allowed MLN-DCs from VA-sufficient mice to induce a similar T-cell subset. IL-6 induced the differentiation of this subset from naive CD4 T cells upon activation with antibodies against CD3 and CD28, and RA receptor antagonists enhanced this induction. It has been considered that VA deficiency reduces Th2-dependent antibody responses. However, oral administration of an antigen to VA-deficient mice failed to induce immune tolerance but primed strong IL-13-dependent immunoglobulin G1 (IgG1) responses and IgE responses that caused skin allergy. These results suggest that MLN-DCs possess the latent ability to induce IL-13-producing inflammatory Th2 cells and that RA prevents them from inducing IL-13-dependent allergic or inflammatory responses to orally administered antigens.
[Mh] Termos MeSH primário: Células Dendríticas/imunologia
Interleucina-13/biossíntese
Células Th2/imunologia
Tretinoína/farmacologia
[Mh] Termos MeSH secundário: Animais
Linfócitos T CD4-Positivos/imunologia
Hipersensibilidade/imunologia
Imunoglobulina E/imunologia
Imunoglobulina G/imunologia
Inflamação/imunologia
Interleucina-13/imunologia
Interleucina-6
Linfonodos/citologia
Mesentério
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Immunoglobulin G); 0 (Interleukin-13); 0 (Interleukin-6); 37341-29-0 (Immunoglobulin E); 5688UTC01R (Tretinoin)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1248/yakushi.17-00153


  5 / 8317 MEDLINE  
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[PMID]:29245362
[Au] Autor:Kim YJ; Kim JS; Cho SH; Bae JI; Sohn CH; Lee YS; Lee JH; Lim KS; Kim WY
[Ad] Endereço:Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
[Ti] Título:Characteristics of computed tomography in hemodynamically unstable blunt trauma patients: Experience at a tertiary care center.
[So] Source:Medicine (Baltimore);96(49):e9168, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Emergent exploratory laparotomy is recommended for hemodynamically unstable blunt trauma patients suspected of having hemoperitoneum. However, given the unreliability of ultrasonography and rapid scan speed of computed tomography (CT), CT might help clinicians provide accurate information even in hemodynamically unstable trauma patients. This observational study aimed to describe the bleeding site and hospital course of severe blunt trauma patients with hemoperitoneum diagnosed by CT scan.We enrolled all consecutive adult blunt trauma patients (≥18 years old) who underwent whole-body CT before operation between February 2012 and October 2016. Patients with hemoperitoneum on CT images were included and categorized into hemodynamically stable and unstable (persistent hypotension despite fluid resuscitation) groups.Among 1723 severe blunt trauma patients, 136 patients with hemoperitoneum were included. Of these, 98 (72.1%) patients had documented intraperitoneal injury, and the liver (60.2%) was most frequently damaged site, followed by spleen (23.5%) and mesentery (23.5%). The rate of intraperitoneal organ injury did not differ between hemodynamically stable (n = 107) and unstable (n = 29) groups (69.2% vs 82.8%, P = .15), while the documented active internal bleeding was high in the unstable group (29.9% vs 69.0%, P < .001). In the unstable group, 14 (48.3%) patients underwent emergent operation, while 3 patients underwent embolization, and the others were treated in a conservative manner.Even in hemodynamically unstable hemoperitoneum patients, 17.2% had no documented intraperitoneal injury and over half of the patients were treated without emergent operation.
[Mh] Termos MeSH primário: Hemorragia/diagnóstico por imagem
Hemorragia/etiologia
Cavidade Peritoneal/lesões
Ferimentos não Penetrantes/complicações
Ferimentos não Penetrantes/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Fígado/lesões
Masculino
Mesentério/lesões
Meia-Idade
Baço/lesões
Centros de Atenção Terciária
Tomografia Computadorizada por Raios X/métodos
Índices de Gravidade do Trauma
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180105
[Lr] Data última revisão:
180105
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009168


  6 / 8317 MEDLINE  
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[PMID]:29049187
[Au] Autor:Wang P; Li Q; Zhang L; Ji H; Zhang CZ; Wang B
[Ad] Endereço:aShandong Medical Imaging Research Institute, School of Medicine, Shandong University, Jinan bDepartment of Radiology cDepartment of Pathology, The Affiliated Hospital of Binzhou Medical University, School of Medicine, Binzhou Medical University, Binzhou dMedical Imaging Research Institute, Department of Radiology, School of Medicine, Binzhou Medical University, Yantai, Shandong, China.
[Ti] Título:A myeloid sarcoma involving the small intestine, kidneys, mesentery, and mesenteric lymph nodes: A case report and literature review.
[So] Source:Medicine (Baltimore);96(42):e7934, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Myeloid sarcomas (MSs) are rare malignant hematological tumors. They most commonly occur in patients with acute or chronic myeloid leukemia. A de novo MS with no evidence of blood system disease is rare, but may represent the first sign of a systemic illness that precedes a full-blown disease. Herein, we report the computed tomography (CT) findings of an extremely rare case of a nonleukemic MS that progressed to acute myelogenous leukemia (AML) and simultaneously involved the small intestine, kidneys, mesentery, and mesenteric lymph nodes. Moreover, we provide CT findings before and after AML chemotherapy, which have not been reported previously. PATIENT CONCERNS: A 25-year-old man with intermittent upper abdominal pain for 6 months was admitted to the hospital on November 28, 2015. Initial CT showed concentric wall thickening of the jejunum with an adjacent mesenteric soft tissue mass and mesenteric lymph nodes enlargement. Both kidneys were involved as indicated by the presence of well-defined mildly dilated lesions. During the laparoscopic surgery, the small intestinal tumor, mesenteric soft tissue mass, and mesenteric lymph nodes were removed. DIAGNOSES: The pathological diagnosis was an MS. INTERVENTIONS: The patient refused systemic chemotherapy and was rehospitalized with persistently aggravated abdominal distension on February 17, 2016. Follow-up CT showed diffuse small bowel wall thickening, widespread infiltration of the peritoneum, omentum, and mesentery, mesenteric lymph node enlargement, and large amounts of ascites fluid. The lesions in both kidneys were substantially larger and more numerous than on initial CT. Then the patient was treated with conventional AML chemotherapy. OUTCOMES: The patient achieved complete hematological remission on bone marrow examination. Follow-up CT in September 4, 2016, showed none of the abnormalities seen on initial CT. Currently, the patient is in complete remission. LESSONS: If the radiological examination shows lesions at multiple sites, and these lesions are soft tissue masses with homogenous enhancement, MS should be considered in the differential diagnosis, and an aspiration biopsy should be performed to provide a definitive pathological diagnosis. If MS is diagnosed, systemic chemotherapy is crucial to recovery; otherwise, the disease may progress rapidly. Medical imaging is helpful for diagnosing MS and for monitoring treatment response.
[Mh] Termos MeSH primário: Neoplasias Intestinais/patologia
Neoplasias Renais/patologia
Neoplasias Primárias Múltiplas/patologia
Neoplasias Peritoneais/patologia
Sarcoma Mieloide/patologia
[Mh] Termos MeSH secundário: Dor Abdominal/diagnóstico
Dor Abdominal/etiologia
Adulto
Diagnóstico Diferencial
Seres Humanos
Neoplasias Intestinais/diagnóstico por imagem
Intestino Delgado/patologia
Rim/patologia
Neoplasias Renais/diagnóstico por imagem
Linfonodos/patologia
Masculino
Mesentério/patologia
Neoplasias Primárias Múltiplas/diagnóstico por imagem
Neoplasias Peritoneais/diagnóstico por imagem
Sarcoma Mieloide/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007934


  7 / 8317 MEDLINE  
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[PMID]:28979630
[Au] Autor:Gomes DC; Quaresma L
[Ad] Endereço:Surgery Service, Hospital Center Lisboa Central, Lisboa, Portugal.
[Ti] Título:Sclerosing mesenteritis: a benign cause of mesenteric mass lesions.
[So] Source:Pan Afr Med J;27:228, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:eng
[Ab] Resumo:Sclerosing mesenteritis is a rare disease of the mesentery. Associations with surgery, trauma, autoimmunity and paraneoplastic syndrome have been suggested, but most of the cases remain idiopathic. Diagnosis is often incidental, based upon the finding of a single or multiple mesenteric lesions on abdominal CT and histopathological confirmation. Optimal treatment is still controversial, but most of the cases reported have a favourable prognosis. We present a case of a 54-year-old male with long-standing abdominal pain and nausea, whose CT revealed the presence of a large mesenteric mass. A biopsy was performed, revealing benign chronic inflammation, fibrosis and IgG4-positive plasmocytes consistent with sclerosing mesenteritis. Clinical remission was achieved with corticosteroids and follow-up CTs at six and twelve months documented stability of the lesion. Furthermore, we review the current literature on the diagnosis and treatment options for this rare disease.
[Mh] Termos MeSH primário: Dor Abdominal/etiologia
Mesentério/patologia
Paniculite Peritoneal/diagnóstico
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Biópsia
Seguimentos
Seres Humanos
Masculino
Mesentério/diagnóstico por imagem
Meia-Idade
Paniculite Peritoneal/tratamento farmacológico
Paniculite Peritoneal/patologia
Prognóstico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.228.11542


  8 / 8317 MEDLINE  
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[PMID]:28922370
[Au] Autor:Perry T; Laffin M; Fedorak RN; Thiesen A; Dicken B; Madsen KL
[Ad] Endereço:Department of Surgery, University of Alberta, Edmonton, Alberta, Canada.
[Ti] Título:Ileocolic resection is associated with increased susceptibility to injury in a murine model of colitis.
[So] Source:PLoS One;12(9):e0184660, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ileocolic resection (ICR) is the most common intestinal resection performed for Crohn's disease, with recurrences commonly occurring at the site of the anastomosis. This study used an animal model of ICR in wild-type mice to examine immunologic changes that developed around the surgical anastomosis and how these changes impacted gut responses to minor acute injury. ICR was performed in adult 129S1/SvlmJ mice and results compared with mice receiving sham or no surgery. Dextran sodium sulfate was given either on post-operative day 9 or day 24 to evaluate immune responses in the intestine both immediately following surgery and after a period of healing. Fecal occult blood measurements and animal weights were taken daily. Cytokine levels were measured in ileal and colonic tissue. Bacterial load in the neo-terminal ileum was measured using qPCR. Immune cell populations in the intestinal tissue, mesenteric lymph nodes, and spleen were assessed using flow cytometry. Cytokine secretion in response to microbial products was measured in isolated mesenteric lymph nodes and spleen cells. ICR resulted in an initial elevation of inflammatory markers in the terminal ileum and colon followed by enhanced levels of bacterial growth in the neo-terminal ileum. Intestinal surgical resection resulted in the recruitment of innate immune cells into the colon that exhibited a non-responsiveness to microbial stimuli. DSS colitis phenotype was more severe in the ileocolic resection groups and this was associated with local and systemic immunosuppression as evidenced by a reduced cytokine responses to microbial stimuli. This study reveals the development of an immune non-responsiveness to microbial products following ileocolic resection that is associated with enhanced levels of bacterial growth in the neo-terminal ileum. These surgical-induced altered immune-microbial interactions in the intestine may contribute to disease recurrence at the surgical anastomosis site following ileocolic resections in patients with Crohn's disease.
[Mh] Termos MeSH primário: Colo
Doença de Crohn
Microbioma Gastrointestinal/imunologia
Íleo
[Mh] Termos MeSH secundário: Animais
Colo/imunologia
Colo/microbiologia
Colo/cirurgia
Doença de Crohn/induzido quimicamente
Doença de Crohn/imunologia
Doença de Crohn/microbiologia
Doença de Crohn/cirurgia
Sulfato de Dextrana/toxicidade
Modelos Animais de Doenças
Íleo/imunologia
Íleo/microbiologia
Íleo/cirurgia
Linfonodos/imunologia
Mesentério/imunologia
Camundongos
Camundongos Endogâmicos ICR
Sangue Oculto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9042-14-2 (Dextran Sulfate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170919
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0184660


  9 / 8317 MEDLINE  
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[PMID]:28904661
[Au] Autor:Ouedraogo S; Ouedraogo S; Kambire JL; Zida M; Sanou A
[Ad] Endereço:Centre Hospitalier Universitaire d'Ouahigouya, Ouahigouya, Burkina Faso.
[Ti] Título:[Occlusion secondary to congenital internal transmesenteric hernia: about 2 cases].
[Ti] Título:Occlusion par hernie interne transmesenterique congénitale: à propos de deux cas..
[So] Source:Pan Afr Med J;27:131, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Internal hernia due to mesenteric defect or transmesenteric hernia is a rare cause of acute intestinal obstruction. Its diagnosis is most often done during surgery. The knowledge of its clinical peculiarities allows the preoperative diagnosis. We here report 2 cases of acute intestinal obstruction secondary to congenital transmesenteric hernia in two adult patients. This study aims to highlight the clinical peculiarities of this rare form of internal hernia.
[Mh] Termos MeSH primário: Hérnia Abdominal/complicações
Obstrução Intestinal/etiologia
[Mh] Termos MeSH secundário: Adulto
Feminino
Hérnia Abdominal/congênito
Hérnia Abdominal/diagnóstico
Seres Humanos
Masculino
Mesentério
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170915
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.131.12203


  10 / 8317 MEDLINE  
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[PMID]:28851707
[Au] Autor:Wang Y; Jin Y; Mäe MA; Zhang Y; Ortsäter H; Betsholtz C; Mäkinen T; Jakobsson L
[Ad] Endereço:Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Division of Vascular Biology, Scheeles Väg 2, SE171 77 Stockholm, Sweden.
[Ti] Título:Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity.
[So] Source:Development;144(19):3590-3601, 2017 10 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tissue fluid drains through blind-ended lymphatic capillaries, via smooth muscle cell (SMC)-covered collecting vessels into venous circulation. Both defective SMC recruitment to collecting vessels and ectopic recruitment to lymphatic capillaries are thought to contribute to vessel failure, leading to lymphedema. However, mechanisms controlling lymphatic SMC recruitment and its role in vessel maturation are unknown. Here, we demonstrate that platelet-derived growth factor B (PDGFB) regulates lymphatic SMC recruitment in multiple vascular beds. PDGFB is selectively expressed by lymphatic endothelial cells (LECs) of collecting vessels. LEC-specific deletion of prevented SMC recruitment causing dilation and failure of pulsatile contraction of collecting vessels. However, vessel remodelling and identity were unaffected. Unexpectedly, overexpression in LECs did not induce SMC recruitment to capillaries. This was explained by the demonstrated requirement of PDGFB extracellular matrix (ECM) retention for lymphatic SMC recruitment, and the low presence of PDGFB-binding ECM components around lymphatic capillaries. These results demonstrate the requirement of LEC-autonomous PDGFB expression and retention for SMC recruitment to lymphatic vessels, and suggest an ECM-controlled checkpoint that prevents SMC investment of capillaries, which is a common feature in lymphedematous skin.
[Mh] Termos MeSH primário: Células Endoteliais/metabolismo
Vasos Linfáticos/anatomia & histologia
Vasos Linfáticos/metabolismo
Miócitos de Músculo Liso/metabolismo
Proteínas Proto-Oncogênicas c-sis/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Capilares/metabolismo
Comunicação Celular
Derme/metabolismo
Matriz Extracelular/metabolismo
Feminino
Membro Posterior/metabolismo
Masculino
Mesentério/metabolismo
Morfogênese
Tamanho do Órgão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Proto-Oncogene Proteins c-sis)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1242/dev.147967



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