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[PMID]: 29231023 [Au] Autor: Zhang WL; Du YL [Ad] Endereço: Criminal Technology Branch, Agricultural Areas Public Security Bureau, Harbin 150038, China. [Ti] Título: [Analysis on the Injury Mechanism and Characteristics of Ox Horn]. [So] Source: Fa Yi Xue Za Zhi;33(2):162-164, 2017 Apr. [Is] ISSN: 1004-5619 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: OBJECTIVES: To study the morphological characteristics of the injury caused by ox horn on human body and its injury mechanism, and to discuss the rules and characteristics of injury by ox horn and provide forensic evidences for identification of such cases. METHODS: The comparative analysis of position and morphological characteristics were performed by summarizing the data of 100 victims gored by ox accepted by Heilongjiang agricultural areas public security bureau during 2004-2014. RESULTS: The specific injuries only could be found at the contact positions such as thorax and abdomen, lower back and limbs of the victims gored by ox horn. Most of the skin wounds had the characteristics of sharp injuries, the bar-type injury by club which called "rail way bruise" was an obvious characteristic appeared on the soft tissue. CONCLUSIONS: Ox horn can cause non-specific injuries on thorax and abdomen, lower back and limbs of human body, which are similar with the characteristics of sharp injury and injury by club. Careful analyzation and identification should be performed on such injury in daily work. [Mh] Termos MeSH primário: Traumatismos Abdominais/etiologia Tórax Ferimentos e Lesões/etiologia Ferimentos Penetrantes [Mh] Termos MeSH secundário: Animais Bovinos Feminino Seres Humanos Extremidade Inferior [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171213 [St] Status: MEDLINE [do] DOI: 10.3969/j.issn.1004-5619.2017.02.011

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[PMID]: 29231007 [Au] Autor: Du YL; Zhang WL [Ad] Endereço: Nine-three Reclamation Public Security Bureau, Nenjiang 161441, China. [Ti] Título: [Automobile Traffic Accident Death Case Analysis of Characteristics of Driver Injury]. [So] Source: Fa Yi Xue Za Zhi;33(1):36-37, 2017 Feb. [Is] ISSN: 1004-5619 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: OBJECTIVES: To distinguish the injury characteristic changes on the drivers between the injuries of drivers and passengers in traffic accidents, and to provide scientific evidence for confirming the identity of driver in traffic accidents. METHODS: Data of 126 automobile traffic accident death cases in the reclamation areas of Heilongjiang province from 2006-2014 were retrospectively studied. The injury characteristics on the drivers of automobile traffic accident death cases were analyzed and the forensic identification problem in the injuries of drivers and passengers were discussed. RESULTS: Injuries were frequently observed on driver's neck, chest and abdomen. The characteristic injuries caused by auto parts were also found, which appeared at the places of passenger's head, face and limbs contacted with automobile. Such characteristic injuries were not found at other places. CONCLUSIONS: The location and type of injury are associated with the identity of the deceased. [Mh] Termos MeSH primário: Acidentes de Trânsito/mortalidade Condução de Veículo/estatística & dados numéricos [Mh] Termos MeSH secundário: Acidentes de Trânsito/estatística & dados numéricos Automóveis China/epidemiologia Morte Extremidades/lesões Feminino Cabeça Seres Humanos Estudos Retrospectivos Tórax [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180308 [Lr] Data última revisão: 180308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171213 [St] Status: MEDLINE [do] DOI: 10.3969/j.issn.1004-5619.2017.01.009

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[PMID]: 29351567 [Au] Autor: Ghandhi SA; Turner HC; Shuryak I; Dugan GO; Bourland JD; Olson JD; Tooze JA; Morton SR; Batinic-Haberle I; Cline JM; Amundson SA [Ad] Endereço: Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America. [Ti] Título: Whole thorax irradiation of non-human primates induces persistent nuclear damage and gene expression changes in peripheral blood cells. [So] Source: PLoS One;13(1):e0191402, 2018. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: We investigated the cytogenetic and gene expression responses of peripheral blood cells of non-human primates (NHP, Macaca mulatta) that were whole-thorax irradiated with a single dose of 10 Gy. In this model, partial irradiation of NHPs in the thoracic region (Whole Thorax Lung Irradiation, WTLI) allows the study of late radiation-induced lung injury, while avoiding acute radiation syndromes related to hematopoietic and gastrointestinal injury. A transient drop in circulating lymphocytes and platelets was seen by 9 days, followed by elevations in respiratory rate, circulating neutrophils, lymphocytes, and monocytes at 60-100 days, corresponding to computed tomography (CT) and histologic evidence of pneumonitis, and elective euthanasia of four animals. To evaluate long-term DNA damage in NHP peripheral blood lymphocytes after 10 Gy WTLI, we used the cytokinesis-block micronucleus (CBMN) assay to measure chromosomal aberrations as post-mitotic micronuclei in blood samples collected up to 8 months after irradiation. Regression analysis showed significant induction of micronuclei in NHP blood cells that persisted with a gradual decline over the 8-month study period, suggesting long-term DNA damage in blood lymphocytes after WTLI. We also report transcriptomic changes in blood up to 30 days after WTLI. We isolated total RNA from peripheral blood at 3 days before and then at 2, 5 and 30 days after irradiation. We identified 1187 transcripts that were significantly changed across the 30-day time course. From changes in gene expression, we identified biological processes related to immune responses, which persisted across the 30-day study. Response to oxygen-containing compounds and bacteria were implicated by gene-expression changes at the earliest day 2 and latest, day 30 time-points. Gene expression changes suggest a persistent altered state of the immune system, specifically response to infection, for at least a month after WTLI. [Mh] Termos MeSH primário: Células Sanguíneas/metabolismo Células Sanguíneas/efeitos da radiação Dano ao DNA Expressão Gênica/efeitos da radiação [Mh] Termos MeSH secundário: Animais Contagem de Células Sanguíneas Aberrações Cromossômicas Relação Dose-Resposta à Radiação Ontologia Genética Seres Humanos Lesão Pulmonar/sangue Lesão Pulmonar/etiologia Lesão Pulmonar/genética Macaca mulatta/sangue Macaca mulatta/genética Masculino Testes para Micronúcleos Lesões Experimentais por Radiação/sangue Lesões Experimentais por Radiação/genética Tórax/efeitos da radiação Fatores de Tempo [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1803 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180120 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0191402

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[PMID]: 27770258 [Au] Autor: Franke D; Steffens R; Thomas L; Pavicic L; Ahlenstiel T; Pape L; Gellermann J; Müller D; Querfeld U; Haffner D; Zivicnjak M [Ad] Endereço: Department of Pediatric Kidney, Liver and Metabolic Diseases, Children's Hospital, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany. [Ti] Título: Kidney transplantation fails to provide adequate growth in children with chronic kidney disease born small for gestational age. [So] Source: Pediatr Nephrol;32(3):511-519, 2017 Mar. [Is] ISSN: 1432-198X [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: BACKGROUND: Children with chronic kidney disease are frequently born small for gestational age (SGA) and prone to disproportionately short stature. It is unclear how SGA affects growth after kidney transplantation (KTx). METHODS: Linear growth (height, sitting height, and leg length) was prospectively investigated in a cohort of 322 pediatric KTx recipients, with a mean follow-up of 4.9 years. Sitting height index (ratio of sitting height to total body height) was used to assess body proportions. Predictors of growth outcome in KTx patients with (n = 94) and without (n = 228) an SGA history were evaluated by the use of linear mixed-effects models. RESULTS: Mean z-scores for all linear body dimensions were lower in SGA compared with non-SGA patients (p < 0.001). SGA patients presented with higher target height deficit and degree of body disproportion (p < 0.001). The latter was mainly due to reduced leg growth during childhood. Pubertal trunk growth was diminished in SGA patients, and the pubertal growth spurt of legs was delayed in both groups, resulting in further impairment of adult height, which was more frequently reduced in SGA than in non-SGA patients (50 % vs 18 %, p < 0.001). Use of growth hormone treatment in the pre-transplant period, preemptive KTx, transplant function, and control of metabolic acidosis were the only potentially modifiable correlates of post-transplant growth in SGA groups. By contrast, living related KTx, steroid exposure, and degree of anemia proved to be correlates in non-SGA only. CONCLUSIONS: In children born SGA, growth outcome after KTx is significantly more impaired and affected by different clinical parameters compared with non-SGA patients. [Mh] Termos MeSH primário: Transtornos do Crescimento/etiologia Transplante de Rim/métodos Insuficiência Renal Crônica/cirurgia [Mh] Termos MeSH secundário: Adolescente Envelhecimento Criança Pré-Escolar Estudos de Coortes Feminino Crescimento Seres Humanos Lactente Recém-Nascido Recém-Nascido Pequeno para a Idade Gestacional Perna (Membro)/crescimento & desenvolvimento Modelos Lineares Masculino Estudos Prospectivos Insuficiência Renal Crônica/complicações Insuficiência Renal Crônica/patologia Maturidade Sexual Tórax/crescimento & desenvolvimento [Pt] Tipo de publicação: JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180227 [Lr] Data última revisão: 180227 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161023 [St] Status: MEDLINE [do] DOI: 10.1007/s00467-016-3503-5

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[PMID]: 28466009 [Au] Autor: Han G; Liu X; Soomro NQ; Sun J; Zhao Y; Zhao X; Zhou C [Ad] Endereço: Beijing Key Laboratory of Intelligent Information Technology, School of Computer Science and Technology, Beijing Institute of Technology, Beijing, China. [Ti] Título: Empirical Driven Automatic Detection of Lobulation Imaging Signs in Lung CT. [So] Source: Biomed Res Int;2017:3842659, 2017. [Is] ISSN: 2314-6141 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Computer-aided detection (CAD) of lobulation can help radiologists to diagnose/detect lung diseases easily and accurately. Compared to CAD of nodule and other lung lesions, CAD of lobulation remained an unexplored problem due to very complex and varying nature of lobulation. Thus, many state-of-the-art methods could not detect successfully. Hence, we revisited classical methods with the capability of extracting undulated characteristics and designed a sliding window based framework for lobulation detection in this paper. Under the designed framework, we investigated three categories of lobulation classification algorithms: template matching, feature based classifier, and bending energy. The resultant detection algorithms were evaluated through experiments on LISS database. The experimental results show that the algorithm based on combination of global context feature and BOF encoding has best overall performance, resulting in 1 score of 0.1009. Furthermore, bending energy method is shown to be appropriate for reducing false positives. We performed bending energy method following the LIOP-LBP mixture feature, the average positive detection per image was reduced from 30 to 22, and 1 score increased to 0.0643 from 0.0599. To the best of our knowledge this is the first kind of work for direct lobulation detection and first application of bending energy to any kind of lobulation work. [Mh] Termos MeSH primário: Neoplasias Pulmonares/diagnóstico por imagem Pulmão/diagnóstico por imagem Nódulo Pulmonar Solitário/diagnóstico por imagem Tomografia Computadorizada por Raios X/métodos [Mh] Termos MeSH secundário: Seres Humanos Pulmão/fisiopatologia Neoplasias Pulmonares/diagnóstico Neoplasias Pulmonares/patologia Reconhecimento Automatizado de Padrão Intensificação de Imagem Radiográfica Interpretação de Imagem Radiográfica Assistida por Computador Nódulo Pulmonar Solitário/diagnóstico Tórax/diagnóstico por imagem Tórax/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180216 [Lr] Data última revisão: 180216 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170504 [St] Status: MEDLINE [do] DOI: 10.1155/2017/3842659

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[PMID]: 28678610 [Au] Autor: Viano DC; Parenteau CS; Burnett R; Prasad P [Ad] Endereço: a ProBiomechanics LLC , Bloomfield Hills , Michigan. [Ti] Título: Occupant responses in conventional and ABTS seats in high-speed rear sled tests. [So] Source: Traffic Inj Prev;19(1):54-59, 2018 01 02. [Is] ISSN: 1538-957X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: This study compared biomechanical responses of a normally seated Hybrid III dummy on conventional and all belts to seat (ABTS) seats in 40.2 km/h (25 mph) rear sled tests. It determined the difference in performance with modern (≥2000 MY) seats compared to older (<2000 MY) seats and ABTS seats. METHODS: The seats were fixed in a sled buck subjected to a 40.2 km/h (25 mph) rear sled test. The pulse was a 15 g double-peak acceleration with 150 ms duration. The 50th percentile Hybrid III was lap-shoulder belted in the FMVSS 208 design position. The testing included 11 <2000 MY, 8 ≥2000 MY, and 7 ABTS seats. The dummy was fully instrumented, including head accelerations, upper and lower neck 6-axis load cells, chest acceleration, thoracic and lumbar spine load cells, and pelvis accelerations. The peak responses were normalized by injury assessment reference values (IARVs) to assess injury risks. Statistical analysis was conducted using Student's t test. High-speed video documented occupant kinematics. RESULTS: Biomechanical responses were lower with modern (≥2000 MY) seats than older (<2000 MY) designs. The lower neck extension moment was 32.5 ± 9.7% of IARV in modern seats compared to 62.8 ± 31.6% in older seats (P =.01). Overall, there was a 34% reduction in the comparable biomechanical responses with modern seats. Biomechanical responses were lower with modern seats than ABTS seats. The lower neck extension moment was 41.4 ± 7.8% with all MY ABTS seats compared to 32.5 ± 9.7% in modern seats (P =.07). Overall, the ABTS seats had 13% higher biomechanical responses than the modern seats. CONCLUSIONS: Modern (≥2000 MY) design seats have lower biomechanical responses in 40.2 km/h rear sled tests than older (<2000 MY) designs and ABTS designs. The improved performance is consistent with an increase in seat strength combined with improved occupant kinematics through pocketing of the occupant into the seatback, higher and more forward head restraint, and other design changes. The methods and data presented here provide a basis for standardized testing of seats. However, a complete understanding of seat safety requires consideration of out-of-position (OOP) occupants in high-speed impacts and consideration of the much more common, low-speed rear impacts. [Mh] Termos MeSH primário: Aceleração Acidentes de Trânsito/estatística & dados numéricos Cintos de Segurança/estatística & dados numéricos [Mh] Termos MeSH secundário: Fenômenos Biomecânicos Desenho de Equipamento Cabeça/fisiologia Seres Humanos Vértebras Lombares/fisiologia Masculino Manequins Pescoço/fisiologia Pelve/fisiologia Vértebras Torácicas/fisiologia Tórax/fisiologia Ferimentos e Lesões/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180202 [Lr] Data última revisão: 180202 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170706 [St] Status: MEDLINE [do] DOI: 10.1080/15389588.2017.1347782

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[PMID]: 28594247 [Au] Autor: Juste-Lorente O; Maza M; Lorente AI; Lopez-Valdes FJ [Ad] Endereço: a Impact Laboratory-Aragon Institute for Engineering Research (I3A) , University of Zaragoza , Alcañiz, Teruel , Spain. [Ti] Título: Differences in the kinematics of booster-seated pediatric occupants using two different car seats. [So] Source: Traffic Inj Prev;19(1):18-22, 2018 01 02. [Is] ISSN: 1538-957X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The objective of this article is to compare the performance of forward-facing child restraint systems (CRS) mounted on 2 different seats. METHODS: Two different anthropomorphic test device (ATD) sizes (P3 and P6), using the same child restraint system (a non-ISOFIX high-back booster seat), were exposed to the ECE R44 regulatory deceleration pulse in a deceleration sled. Two different seats (seat A, seat B) were used. Three repetitions per ATD and mounting seat were done, resulting in a total of 12 sled crashes. Dummy sensors measured the head tri-axial acceleration and angular rate and the thorax tri-axial acceleration, all acquired at 10,000 Hz. A high-speed video camera recorded the impact at 1,000 frames per second. The 3D kinematics of the head and torso of the ATDs were captured using a high-speed motion capture system (1,000 Hz). A pair-matched statistical analysis compared the outcomes of the tests using the 2 different seats. RESULTS: Statistically significant differences in the kinematic response of the ATDs associated with the type of seat were observed. The maximum 3 ms peak of the resultant head acceleration was higher on seat A for the P3 dummy (54.5 ± 1.9 g vs. 44.2 ± 0.5 g; P =.012) and for the P6 dummy (56.0 ± 0.8 g vs. 51.7 ± 1.2 g; P =.015). The peak belt force was higher on seat A than on seat B for the P3 dummy (5,488.0 ± 198.0 N vs. 4,160.6 ± 63.6 N; P =.008) and for the P6 dummy (7,014.0 ± 271.0 N vs. 5,719.3 ± 37.4 N; P =.015). The trajectory of the ATD head was different between the 2 seats in the sagittal, transverse, and frontal planes. CONCLUSION: The results suggest that the overall response of the booster-seated occupant exposed to the same impact conditions was different depending on the seat used regardless of the size of the ATD. The differences observed in the response of the occupants between the 2 seats can be attributed to the differences in cushion stiffness, seat pan geometry, and belt geometry. However, these results were obtained for 2 particular seat models and a specific CRS and therefore cannot be directly extrapolated to the generality of vehicle seats and CRS. [Mh] Termos MeSH primário: Acidentes de Trânsito/estatística & dados numéricos Sistemas de Proteção para Crianças/estatística & dados numéricos Cabeça/fisiologia Tronco/fisiologia [Mh] Termos MeSH secundário: Aceleração Fenômenos Biomecânicos Criança Pré-Escolar Desaceleração Desenho de Equipamento Seres Humanos Manequins Tórax/fisiologia Gravação de Videoteipe [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180202 [Lr] Data última revisão: 180202 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170609 [St] Status: MEDLINE [do] DOI: 10.1080/15389588.2017.1334119

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[PMID]: 29173759 [Au] Autor: Zanon M; Pacini GS; de Souza VVS; Marchiori E; Meirelles GSP; Szarf G; Torres FS; Hochhegger B [Ad] Endereço: Department of Clinical Medicine, Federal University of Health Sciences of Porto Alegre, R. Sarmento Leite, 245, Porto Alegre, 90050170, Brazil; Medical Imaging Research Lab, LABIMED, Department of Radiology, Pavilhão Pereira Filho Hospital, Irmandade Santa Casa de Misericórdia de Porto Alegre, Av. I [Ti] Título: Early detection of lung cancer using ultra-low-dose computed tomography in coronary CT angiography scans among patients with suspected coronary heart disease. [So] Source: Lung Cancer;114:1-5, 2017 Dec. [Is] ISSN: 1872-8332 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: OBJECTIVES: To assess whether an additional chest ultra-low-dose CT scan to the coronary CT angiography protocol can be used for lung cancer screening among patients with suspected coronary artery disease. METHODS: 175 patients underwent coronary CT angiography for assessment of coronary artery disease, additionally undergoing ultra-low-dose CT screening to early diagnosis of lung cancer in the same scanner (80kVp and 15mAs). Patients presenting pulmonary nodules were followed-up for two years, repeating low-dose CTs in intervals of 3, 6, or 12 months based on nodule size and growth rate in accordance with National Comprehensive Cancer Network guidelines. RESULTS: Ultra-low-dose CT identified 71 patients with solitary pulmonary nodules (41%), with a mean diameter of 5.50±4.00mm. Twenty-eight were >6mm, and in 79% (n=22) of these cases they were false positive findings, further confirmed by follow-up (n=20), resection (n=1), or biopsy (n=1). Lung cancer was detected in six patients due to CT screening (diagnostic yield: 3%). Among these, four cases could not be detected in the cardiac field of view. Most patients were in early stages of the disease. Two patients diagnosed at advanced stages died due to cancer complications. The addition of the ultra-low-dose CT scan represented a radiation dose increment of 1.22±0.53% (effective dose, 0.11±0.03mSv). CONCLUSIONS: Lung cancer might be detected using additional ultra-low-dose protocols in coronary CT angiography scans among patients with suspected coronary artery disease. [Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada/métodos Doença das Coronárias/diagnóstico por imagem Detecção Precoce de Câncer/métodos Neoplasias Pulmonares/diagnóstico por imagem Tórax/diagnóstico por imagem Tomografia Computadorizada por Raios X/métodos [Mh] Termos MeSH secundário: Idoso Doença das Coronárias/complicações Doença das Coronárias/patologia Feminino Seres Humanos Neoplasias Pulmonares/patologia Masculino Programas de Rastreamento Meia-Idade Nódulos Pulmonares Múltiplos/diagnóstico por imagem Nódulos Pulmonares Múltiplos/epidemiologia Prevalência Estudos Prospectivos Dose de Radiação Nódulo Pulmonar Solitário/diagnóstico por imagem Nódulo Pulmonar Solitário/epidemiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180131 [Lr] Data última revisão: 180131 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171128 [St] Status: MEDLINE

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[PMID]: 29205223 [Au] Autor: Xiao S; Yang J; Crandall JR [Ad] Endereço: School of Mechanical Engineering, Hebei University of Technology, Tianjin, China. [Ti] Título: Investigation of chest injury mechanism caused by different seatbelt loads in frontal impact. [So] Source: Acta Bioeng Biomech;19(3):53-62, 2017. [Is] ISSN: 1509-409X [Cp] País de publicação: Poland [La] Idioma: eng [Ab] Resumo: PURPOSE: The purpose of this quantitative study is to investigate the differences of the injury mechanism caused by two different types of seatbelt loads on the occupant's chest. METHODS: The finite element analysis is employed to compare the different responses of the human body model, including comparison of kinematics, chest accelerations, seatbelt forces and chest injury outcomes regarding chest deflections and rib fractures. RESULTS: The calculated rib strain-stress response from simulations in force-limiting seatbelt are higher than that in the regular seatbelt. The forward movement and torso twist are both great in simulations with force-limiting seatbelt. Moreover, there are obvious differences in the injury outcomes of chest deflections and rib fracture risks under the different seatbelt loads. CONCLUSION: Results indicate that the chest deflections and rib fracture risks are negatively correlated under the load of the force-limiting seatbelt, However, they are positively correlated to and determined by the seatbelt peak load of the regular seatbelt. This paper can provide a reference for study of the chest injury mechanism and protection efficiency of seatbelt. [Mh] Termos MeSH primário: Aceleração/efeitos adversos Modelos Biológicos Estimulação Física/efeitos adversos Cintos de Segurança/efeitos adversos Traumatismos Torácicos/etiologia Traumatismos Torácicos/fisiopatologia [Mh] Termos MeSH secundário: Acidentes de Trânsito Simulação por Computador Seres Humanos Costelas/fisiopatologia Estresse Mecânico Tórax/fisiopatologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180129 [Lr] Data última revisão: 180129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171206 [St] Status: MEDLINE

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[PMID]: 27771125 [Au] Autor: Jegou MH; Huet P; Penchet I [Ad] Endereço: Cabinet de dermatologie, 8, rue Jules-Ferry, 33290 Blanquefort, France. Electronic address: mh.jegou@free.fr. [Ti] Título: [Nested melanoma]. [Ti] Título: Mélanome en thèques.. [So] Source: Ann Dermatol Venereol;144(1):60-64, 2017 Jan. [Is] ISSN: 0151-9638 [Cp] País de publicação: France [La] Idioma: fre [Ab] Resumo: BACKGROUND: Nested melanoma in elderly subjects is an entity that has been reported in the literature only since 2012. In this paper, we describe its distinctive clinical, dermatoscopic and histopathological features and compare them to previous published cases, with the aim of highlighting certain specific criteria of this melanoma subtype. CASE REPORT: A 52-year-old man was referred for the presence on his chest of a large suspicious pigmented lesion of irregular shape and colour. Dermatoscopically, the lesion was chaotic and characterized by a black, structureless, eccentric area with some peripheral globules as well as some segmental radial lines. Histopathological examination revealed the presence of an asymmetric lesion with large junctional melanocytic nests showing a focal tendency to gathering and some cytological atypia. A diagnosis of nested melanoma was ultimately made. DISCUSSION: Nested melanoma of the elderly represents a distinct anatomoclinical variant of superficial spreading melanoma. Clinically, the lesion is usually large and occurs in photodamaged skin. We would stress that the "elderly" criterion is not mandatory given the numerous cases reported in people under 60 years. The main dermatoscopic feature is a globular pattern, but several features characteristic of superficial spreading melanoma may also be present. Histological diagnosis may be difficult because of the mainly nested pattern, and the condition may be confused histologically with a benign junctional nevus. But these large junctional nests of different sizes, with bridging and cytonuclear atypias, together with asymmetry of the lesions are the hallmark of this special kind of melanoma. [Mh] Termos MeSH primário: Dermoscopia Melanócitos/patologia Melanoma/diagnóstico Neoplasias Cutâneas/diagnóstico [Mh] Termos MeSH secundário: Dermoscopia/métodos Diagnóstico Diferencial Seres Humanos Masculino Melanoma/patologia Meia-Idade Neoplasias Cutâneas/patologia Tórax/patologia [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180103 [Lr] Data última revisão: 180103 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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