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[PMID]: 28749039 [Au] Autor: Mukhtar BMB; Spilotros M; Malde S; Greenwell TJ [Ad] Endereço: Department of Urology, University College London Hospital at Westmoreland Street, London, UK. [Ti] Título: Ventral-onlay buccal mucosa graft substitution urethroplasty for urethral stricture in women. [So] Source: BJU Int;120(5):710-716, 2017 11. [Is] ISSN: 1464-410X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To present our outcomes of ventral-onlay buccal mucosa graft (BMG) substitution urethroplasty in treating female urethral stricture (FUS). PATIENTS AND METHODS: We conducted a review of a prospectively collected database of 22 consecutive women (median [range] age 50 [34-72] years) with urethral stricture who underwent ventral onlay BMG substitution urethroplasty after June 2012 and who had a minimum follow-up of 6 months (median 21.5, range 6-51 months). Data were analysed for stricture recurrence, change in median maximum urinary flow rate (Q ) and median post-void residual urine volume (PVR). Statistical analysis was performed using the Wilcoxon signed rank test, Student's t-test and the Mann-Whitney U-test. RESULTS: Freedom from stricture recurrence was achieved in 21/22 (95.5%) women. The median (range) Q significantly improved, increasing from 7 (3.5-11) to 18 (5-37) mL/s (P <0.05). The median (range) PVR was significantly reduced from 100 (0-300) to 15 (0-150) mL (P < 0.05). Short- and longer-term complication rates were low. One woman developed mild de novo stress urinary incontinence, which settled with conservative management by 6 months. CONCLUSIONS: Early and medium-term results indicate that ventral onlay BMG substitution urethroplasty is an excellent treatment for FUS that can avoid the need for the repeat procedures regularly required after traditional endoscopic management. [Mh] Termos MeSH primário: Mucosa Bucal/cirurgia Transplantes/cirurgia Transplantes/transplante Uretra/cirurgia Estreitamento Uretral/cirurgia Procedimentos Cirúrgicos Urológicos/métodos [Mh] Termos MeSH secundário: Adulto Idoso Feminino Seres Humanos Meia-Idade Complicações Pós-Operatórias Estudos Prospectivos Procedimentos Cirúrgicos Urológicos/efeitos adversos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 180305 [Lr] Data última revisão: 180305 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170728 [St] Status: MEDLINE [do] DOI: 10.1111/bju.13970

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[PMID]: 29308838 [Au] Autor: Vasyutin IA; Lyundup AV; Viranov AZ; Butnaru DV; Kuznetsov SL [Ti] Título: Urethra Reconstruction with Tissue-Engineering Technology. [So] Source: Vestn Ross Akad Med Nauk;72(1):17-25, 2017. [Is] ISSN: 0869-6047 [Cp] País de publicação: Russia (Federation) [La] Idioma: eng [Ab] Resumo: Urethral stricture is a disease characterized by a pathological narrowing of the urethra. Treatment for this condition often requires surgery using autologous grafts (urethroplasty). It is common practice to use patient's own tissue like genital and extragenital skin, tunica vaginalis, buccal mucosa as a source of the graft. Alternative and safer approach is to use tissue-engineered graft created in a laboratory using patient's autologous cells and biocompatible matrix (scaffold). The article presents the up-to-date achievements in lab-created tissue-engineered graft, describes all components needed to build a tissue-engineered structure of the graft for urethroplasty, and summarizes authors' thoughts on advantages and disadvantages of various approaches to choose both cellular component and the matrix of future construction. The article reviews clinical studies conducted in the field of tissue engineering of the graft material for urethraplasty. [Mh] Termos MeSH primário: Procedimentos Cirúrgicos Reconstrutivos Engenharia Tecidual/métodos Uretra/cirurgia Estreitamento Uretral/cirurgia Procedimentos Cirúrgicos Urológicos [Mh] Termos MeSH secundário: Seres Humanos Procedimentos Cirúrgicos Reconstrutivos/instrumentação Procedimentos Cirúrgicos Reconstrutivos/métodos Tecidos Suporte Transplantes/classificação Procedimentos Cirúrgicos Urológicos/instrumentação Procedimentos Cirúrgicos Urológicos/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180220 [Lr] Data última revisão: 180220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180109 [St] Status: MEDLINE [do] DOI: 10.15690/vramn771

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[PMID]: 29276997 [Au] Autor: Chae YK; Galvez C; Anker JF; Iams WT; Bhave M [Ad] Endereço: Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL, USA. Electronic address: young.chae@northwestern.edu. [Ti] Título: Cancer immunotherapy in a neglected population: The current use and future of T-cell-mediated checkpoint inhibitors in organ transplant patients. [So] Source: Cancer Treat Rev;63:116-121, 2018 Feb. [Is] ISSN: 1532-1967 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Although the indications for immune checkpoint inhibitors continue to grow, organ transplant recipients with advanced malignancies have been largely excluded from clinical trials testing the safety and efficacy of these therapies given their need for chronic immunosuppression and the risk of allograft rejection. With the rapid growth of transplant medicine and the increased risk of malignancy associated with chronic immunosuppression, it is critical that we systematically analyze the available data describing immune checkpoint blockade in the organ transplant population. Herein we provide a current and comprehensive review of cases in which immune checkpoint blockade was used on organ transplant recipients. Furthermore, we discuss the differences in efficacy and risk of allograft rejection between CTLA-4 and PD-1 inhibitors and make recommendations based on the limited available clinical data. We also discuss the future of immune checkpoint blockade in this subpopulation and explore the emerging data of promising combination therapies with mTOR, BRAF/MEK, and BTK/ITK inhibitors. Further clinical experience and larger clinical trials involving immune checkpoint inhibitors, whether as monotherapies or combinatorial therapies, will help develop regimens that optimize anti-tumor response and minimize the risk of allograft rejection in organ transplant patients. [Mh] Termos MeSH primário: Neoplasias/imunologia Neoplasias/terapia Linfócitos T/imunologia Transplantes/imunologia [Mh] Termos MeSH secundário: Animais Seres Humanos Imunoterapia/métodos Transplantados [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180209 [Lr] Data última revisão: 180209 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171226 [St] Status: MEDLINE

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[PMID]: 29326255 [Au] Autor: Shultz D [Ti] Título: Creating a modern monster. [So] Source: Science;359(6372):151, 2018 Jan 12. [Is] ISSN: 1095-9203 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Órgãos Artificiais Biônica Clonagem de Organismos Técnicas de Cultura de Órgãos Transplantes [Mh] Termos MeSH secundário: Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180207 [Lr] Data última revisão: 180207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.1126/science.359.6372.151

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[PMID]: 28468144 [Au] Autor: Aksu AE; Uzun H; Bitik O; Tunçbilek G; Safak T [Ad] Endereço: Department of Plastic, Reconstructive and Aesthetic Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey. [Ti] Título: Microvascular Tissue Transfers for Midfacial and Anterior Cranial Base Reconstruction. [So] Source: J Craniofac Surg;28(3):659-663, 2017 May. [Is] ISSN: 1536-3732 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Reconstruction of a midfacial defect can represent a difficult challenge for the plastic surgeon. Although many midfacial deformities have traumatic or congenital origins, the vast majority of head and neck defects occur after resection of malignant head and neck neoplasms. Autogenous reconstruction is now routinely performed for larger, complex defects resulting from surgical resection or trauma. In this study, the authors present 27 patients with midfacial defects reconstructed with free flaps. Twenty-two of the defects were created by surgical ablation of cancer (maxillectomy) and the others were traumatic. The maxillectomy defects were classified into 4 according to the classification proposed by Cordeiro. Eighteen of the patients were male and 9 were female. Twenty-nine free flaps were performed. Six different types of flaps including radial forearm flap, vertical rectus abdominis (VRAM) flap, anterolateral thigh (ALT) flap, tensor fasciae latae (TFL) flap, fibula osteocutaneous flap, and iliac osteocutaneous flap were accomplished. Types I and II defects were reconstructed with radial forearm flap. Type III defects were reconstructed with VRAM and ALT. Type IV defects were reconstructed with VRAM and TFL. Two patients underwent a second flap reconstruction due to recurrent disease (9.1%). Average patient age was 53.1 years. Free-flap survival was 100%. Free tissue transfer is the method of choice in midfacial reconstruction. Following a reconstructive algorithm is useful in the decision-making process for patient evaluation and treatment. Every reconstructive microsurgeon might have different experiences with different flaps. Therefore, the algorithm for flap choices is not universal among surgeons. [Mh] Termos MeSH primário: Fossa Craniana Anterior/cirurgia Traumatismos Faciais/cirurgia Neoplasias Faciais/cirurgia Retalhos de Tecido Biológico/irrigação sanguínea Maxila/cirurgia Microcirurgia/métodos Procedimentos Cirúrgicos Reconstrutivos/métodos Retalhos Cirúrgicos/irrigação sanguínea Retalhos Cirúrgicos/cirurgia Transplantes/irrigação sanguínea Transplantes/cirurgia [Mh] Termos MeSH secundário: Adulto Idoso Ossos Faciais/cirurgia Feminino Seguimentos Neoplasias de Cabeça e Pescoço/cirurgia Seres Humanos Ílio/cirurgia Masculino Meia-Idade Reto do Abdome/transplante Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180126 [Lr] Data última revisão: 180126 [Sb] Subgrupo de revista: D [Da] Data de entrada para processamento: 170505 [St] Status: MEDLINE [do] DOI: 10.1097/SCS.0000000000003448

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[PMID]: 29244937 [Au] Autor: Onishchenko NA [Ti] Título: Cytogenetic recapitulation, induced by medical preparations, as the universal stage of formation of urgent protection against damage at organ transplantation. [So] Source: Patol Fiziol Eksp Ter;60(4):148-53, 2016 Oct-Dec. [Is] ISSN: 0031-2991 [Cp] País de publicação: Russia (Federation) [La] Idioma: eng [Ab] Resumo: In this article modern representations about cellular mechanisms of formation by pharmacological preparations of urgent protection of organs against damage are given at transplantation. On an example of ischemic damage of kidneys it is shown, that at use of preparations of different pharmacological groups by the most expressed protective effect those from them which operating within the limits of a nonspecific adaptive syndrome of cellular systems, clearly induce in organs the evolutional developed signs of cytogenetic recapitulation possess: support a cellular homeostasis at the lowered level at the expense of activation of a glycolysis and conformational reorganizations of macromolecules, and also change in cells of water contain- decrease of free and increase of bound. [Mh] Termos MeSH primário: Citoproteção Preservação Biológica/métodos Substâncias Protetoras/uso terapêutico Transplantes [Mh] Termos MeSH secundário: Animais Seres Humanos [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Protective Agents) [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180118 [Lr] Data última revisão: 180118 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171216 [St] Status: MEDLINE

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[PMID]: 28457418 [Au] Autor: Carraro RM; Nascimento ECT; Szachnowicz S; Camargo PCLB; Campos SV; Afonso JE; Samano MN; Pêgo-Fernandes PM; Dolhnikoff M; Teixeiraa RHOB; Costa AN [Ad] Endereço: Pulmonary Division, Heart Institute (InCor), University of Sao Paulo Medical School, Sao Paulo, Sao Paulo, Brazil. Electronic address: carraro.rafael@gmail.com. [Ti] Título: Histopathological Findings Associated With Gastroesophageal Reflux Disease and Aspiration After Lung Transplantation: Initial Brazilian Single-Center Experience. [So] Source: Transplant Proc;49(4):886-889, 2017 May. [Is] ISSN: 1873-2623 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Gastro-esophageal reflux disease (GERD) and broncho-aspiration (BA) are known to increase the risk for chronic lung allograft dysfunction (CLAD). However, specific lung injury mechanisms are not clearly known. The objective of the study was to describe histopathological findings in surveillance lung transbronchial biopsies that can be correlated with episodes of BA in the lung allograft. METHODS: This retrospective analysis of surveillance transbronchial biopsies was performed in lung transplant recipients, with available data of broncho-alveolar fluid (cultures and cytology), lung function parameters, and esophageal functional tests. RESULTS: Were analyzed 11 patients, divided into 3 groups: (1) GERD group: 4 patients with GERD and CLAD diagnosis; (2) control group: 2 patients without GERD or CLAD; and (3) BA group: 5 patients with foreign material in lung biopsies. A histopathological pattern of neutrophilic bronchitis (NB) was present in 4 of 4 cases in the GERD group and in 1 of 5 cases in the BA group in 2 or more biopsy samples; culture samples were all negative; the 5 NB-positive patients developed CLAD and died (3/5) or needed re-transplantation (2/5). The other 3 patients in the BA group had GERD without NB or CLAD. Both patients in the control group had transient NB in biopsies with positive cultures but remained free of CLAD. CONCLUSIONS: Surveillance transbronchial biopsies may provide useful information other than the evaluation of acute cellular rejection and can help to identify high-risk patients for allograft dysfunction related to gastro-esophageal reflux. [Mh] Termos MeSH primário: Refluxo Gastroesofágico/patologia Transplante de Pulmão/efeitos adversos Complicações Pós-Operatórias/patologia Aspiração Respiratória de Conteúdos Gástricos/patologia [Mh] Termos MeSH secundário: Adulto Biópsia Brasil Feminino Refluxo Gastroesofágico/etiologia Seres Humanos Pulmão/patologia Pulmão/fisiopatologia Transplante de Pulmão/métodos Masculino Meia-Idade Complicações Pós-Operatórias/etiologia Aspiração Respiratória de Conteúdos Gástricos/etiologia Estudos Retrospectivos Transplante Homólogo Transplantes/fisiopatologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180102 [Lr] Data última revisão: 180102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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[PMID]: 28457413 [Au] Autor: Puliti Reigada CH; de Ataide EC; de Almeida Prado Mattosinho T; Boin IFSF [Ad] Endereço: Unit of Liver Transplantation Unit, State University of Campinas, Campinas, Brazil. [Ti] Título: Hepatic Artery Thrombosis After Liver Transplantation: Five-Year Experience at the State University of Campinas. [So] Source: Transplant Proc;49(4):867-870, 2017 May. [Is] ISSN: 1873-2623 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Hepatic artery thrombosis (HAT) is reported in 4%-15% of orthotopic liver transplants. Risk factors include technical error in the anastomosis, vascular anatomic variation, and high microvascular resistance. The aim of this study was to verify the incidence of HAT, early or late, and possible risk factors. METHODS: This was a retrospective study from January 2007 to December 2012 at the State University of Campinas. Variables analyzed were age, sex, cold and warm ischemia times, underlying disease, presence of hepatocellular carcinoma, Model for End-Stage Liver Disease (MELD) score, arterial anatomic variation in the graft, cytomegalovirus (CMV) infection, rejection, biliary complications, retransplantation rate, and survival. RESULTS: The incidence of HAT was 21/263, or 7.9%. Pure average MELD score was 22 ± 7.4. There was vascular anatomic variation in the graft in 14.2% of cases, in the majority (66.6%) a right hepatic artery from the superior mesenteric artery, and 4.76% of patients had CMV infection and acute cellular rejection (1 case each). There were biliary complications in 38% of patients, 13.3% of cases in patients with early HAT, and 100% of patients with late HAT (P = .002). Body mass index in late HAT was higher (P = .01). CONCLUSIONS: Late HAT was related to a significant increase in biliary complications (stenosis), and the survival rate was similar at 5 years. [Mh] Termos MeSH primário: Artéria Hepática Transplante de Fígado/efeitos adversos Fígado/irrigação sanguínea Trombose/epidemiologia Transplantes/irrigação sanguínea [Mh] Termos MeSH secundário: Carcinoma Hepatocelular/cirurgia Isquemia Fria/efeitos adversos Infecções por Citomegalovirus/complicações Feminino Rejeição de Enxerto/virologia Seres Humanos Incidência Fígado/virologia Neoplasias Hepáticas/cirurgia Masculino Artéria Mesentérica Superior Meia-Idade Reoperação/estatística & dados numéricos Estudos Retrospectivos Fatores de Risco Índice de Gravidade de Doença Taxa de Sobrevida Trombose/etiologia Isquemia Quente/efeitos adversos [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1801 [Cu] Atualização por classe: 180102 [Lr] Data última revisão: 180102 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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[PMID]: 28457391 [Au] Autor: Zaouali MA; Panisello A; Lopez A; Folch E; Castro-Benítez C; Adam R; Roselló-Catafau J [Ad] Endereço: Experimental Hepatic Ischemia-Reperfusion Unit, Institut d'Investigacions Biomèdiques de Barcelona (IIBB), CSIC-IDIBAPS, Barcelona, Spain; Research Unit of Biology and Molecular Anthropology Applied to Development and Health (UR12ES11), Faculty of Pharmacy, University of Monastir, Tunisia; High Inst [Ti] Título: Cross-Talk Between Sirtuin 1 and High-Mobility Box 1 in Steatotic Liver Graft Preservation. [So] Source: Transplant Proc;49(4):765-769, 2017 May. [Is] ISSN: 1873-2623 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: BACKGROUND: Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide +-dependent histone deacetylase that regulates various pathways involved in ischemia-reperfusion injury (IRI). Moreover, high-mobility group box 1 protein (HMGB1) has also been involved in inflammatory processes during IRI. However, the roles of both SIRT1 and HMGB1 in liver preservation is poorly understood. In this communication, we evaluated the potential relationship between SIRT1 and HMGB1 in steatotic and non-steatotic liver grafts preserved in Institute Georges Lopez solution (IGL-1) preservation solution enriched or not enriched with trimetazidine (TMZ). METHODS: Steatotic and non-steatotic livers were preserved in IGL-1 preservation solution (24 hours, 4°C), enriched or not enriched with TMZ (10 µmol/L), and then submitted to ex vivo reperfusion (2 hours; 37°C). Liver injury (AST/ALT) and function (bile output, vascular resistance) were evaluated. SIRT1, HMGB1, autophagy parameters (beclin-1, LC3B), PPAR-γ, and heat-shock protein (HO-1, HSP70) expression were determined by means of Western blot. Also, we assessed oxidative stress, mitochondrial damage (glutamate dehydrogenase), and TNF-α levels. RESULTS: Elevated SIRT1 and enhanced autophagy were found after reperfusion in steatotic livers preserved in IGL-1+TMZ when compared with IGL-1. However, these changes were not seen in the case of non-steatotic livers. Also, HO-1 increases in the IGL-1 + TMZ group were evident only in the case of steatotic livers, whereas HSP70 and PPAR-γ protein expression were enhanced only in non-steatotic livers. All reported changes were consistent with decreased liver injury diminution, ameliorated hepatic function, and decreased TNF-α and HMGB levels. In addition, the oxidative stress and mitochondrial damage were efficiently prevented by the IGL-1 + TMZ use. CONCLUSIONS: SIRT1 is associated with HMGB1 decreases and increased autophagy in steatotic livers, contributing to increased tolerance to cold IRI. [Mh] Termos MeSH primário: Fígado Gorduroso/metabolismo Proteína HMGB1/fisiologia Preservação de Órgãos/métodos Sirtuína 1/fisiologia Transplantes/metabolismo [Mh] Termos MeSH secundário: Animais Fígado Gorduroso/cirurgia Proteínas de Choque Térmico/metabolismo Fígado/fisiopatologia Transplante de Fígado Mitocôndrias Hepáticas/metabolismo Soluções para Preservação de Órgãos Estresse Oxidativo Ratos Ratos Zucker Fator de Necrose Tumoral alfa/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (HMGB1 Protein); 0 (Heat-Shock Proteins); 0 (IGL-1 solution); 0 (Organ Preservation Solutions); 0 (Tumor Necrosis Factor-alpha); EC 3.5.1.- (Sirtuin 1) [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171218 [Lr] Data última revisão: 171218 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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[PMID]: 28457360 [Au] Autor: Peritore D; Rizzato L; Di Ciaccio P; Trapani S; Carella C; Oliveti A; Rizzo A; Nanni Costa A [Ad] Endereço: The Italian National Transplant Centre, Istituto Superiore di Sanità, Rome, Italy. Electronic address: daniela.peritore@iss.it. [Ti] Título: Analysis of the Organ Offers Received From European Union Countries Before and After the Introduction of a Dedicated Information Technology Portal: The COORENOR/FOEDUS Portal. [So] Source: Transplant Proc;49(4):629-631, 2017 May. [Is] ISSN: 1873-2623 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: INTRODUCTION: To optimize the use of nontransplantable organs in their own territory, the European Commission, as part of a project led by Italy, has promoted the use of an information technology (IT) portal, the COORENOR portal, developed by the Czech Republic in 2012, which evolved to become FOEDUS in 2015. METHODS: To evaluate the impact of the portal on our reality, we analyzed the number and type of offers received and organs imported in the previous 48 months (period A) as well as the 48 months after the introduction of the portal (period B). We also examined the origin and the offer mode. RESULTS: The offers received were 404 and 753, respectively, in the two periods, with 315 (41.8%) organs received through the portal. The organs transplanted were 53 and 64, respectively, in the two periods; 20 (31.2%) were sent through the portal. The most commonly offered organs are lungs (36.7% and 29.3% of offers in periods A and B, respectively). The most transplanted organ is the liver (59.4% and 45% of transplants in periods A and B, respectively). The use of the portal has gradually increased, growing from 16.4% of the offer mode in 2012 to 84.7% in 2016. CONCLUSIONS: The increase of offers related to the increase of donations and the attitude to the sharing of resources has determined an increase of 19.2% of total transplants, especially for certain types such as pediatric transplants. The portal, ensuring speed and simultaneity of offer, real time sharing of information and transparency of allocation, is also used for trade in the International Partnership Agreements. Therefore, transplants have been conditioned by the existing agreements with Greece, Malta, and the countries of the South Transplant Alliance. [Mh] Termos MeSH primário: Tecnologia da Informação Obtenção de Tecidos e Órgãos/métodos Transplantes/estatística & dados numéricos [Mh] Termos MeSH secundário: República Tcheca União Europeia Grécia Seres Humanos Itália [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1712 [Cu] Atualização por classe: 171212 [Lr] Data última revisão: 171212 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170502 [St] Status: MEDLINE

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