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[PMID]:29174111
[Au] Autor:Lelong AG; Mallet S; Le Treut C; Dubus JC; Carsin A; Bosdure E
[Ad] Endereço:Unité de médecin infantile, CHU Timone-Enfants, 264, rue Saint-Pierre, 13385 Marseille cedex 05, France.
[Ti] Título:[Pseudomonas aeruginosa in post-piercing perichondritis: Two case reports].
[Ti] Título:Chondrite à Pseudomonas aeruginosa après piercing chez l'adolescent : à propos de deux cas..
[So] Source:Arch Pediatr;24(12):1235-1240, 2017 Dec.
[Is] ISSN:1769-664X
[Cp] País de publicação:France
[La] Idioma:fre
[Ab] Resumo:The frequency of body piercing has increased in France over the past few years, particularly among teenagers. Piercing can be performed at different sites on the body, especially in the cartilage of the ears. We relate two cases of Pseudomonas aeruginosa chondritis. A 10-year retrospective study at the Marseille University Hospital found no additional pediatric cases. These infectious complications can sometimes be necrotizing. It is therefore important to inform the medical staff on the hygiene measures that need to be respected and the patients on the treatment to follow after the piercing as well as the signs to watch for, possibly indicating chondritis. The esthetic consequences depend on early diagnosis.
[Mh] Termos MeSH primário: Piercing Corporal/efeitos adversos
Cartilagem da Orelha
Infecções por Pseudomonas/etiologia
Pseudomonas aeruginosa
[Mh] Termos MeSH secundário: Adolescente
Feminino
Seres Humanos
Inflamação/microbiologia
Estudos Retrospectivos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28574571
[Au] Autor:Fujihara Y; Hikita A; Takato T; Hoshi K
[Ad] Endereço:Department of Oral-Maxillofacial Surgery and Orthodontics, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
[Ti] Título:Roles of macrophage migration inhibitory factor in cartilage tissue engineering.
[So] Source:J Cell Physiol;233(2):1490-1499, 2018 Feb.
[Is] ISSN:1097-4652
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To obtain stable outcomes in regenerative medicine, understanding and controlling immunological responses in transplanted tissues are of great importance. In our previous study, auricular chondrocytes in tissue-engineered cartilage transplanted in mice were shown to express immunological factors, including macrophage migration inhibitory factor (MIF). Since MIF exerts pleiotropic functions, in this study, we examined the roles of MIF in cartilage regenerative medicine. We made tissue-engineered cartilage consisting of auricular chondrocytes of C57BL/6J mouse, atellocollagen gel and a PLLA scaffold, and transplanted the construct subcutaneously in a syngeneic manner. Localization of MIF was prominent in cartilage areas of tissue-engineered cartilage at 2 weeks after transplantation, though it became less apparent by 8 weeks. Co-culture with RAW264 significantly increased the expression of MIF in chondrocytes, suggesting that the transplanted chondrocytes in tissue-engineered cartilage could enhance the expression of MIF by stimulation of surrounding macrophages. When MIF was added in the culture of chondrocytes, the expression of type II collagen was increased, indicating that MIF could promote the maturation of chondrocytes. Meanwhile, toluidine blue staining of constructs containing wild type (Mif+/+) chondrocytes showed increased metachromasia compared to MIF-knockout (Mif-/-) constructs at 2 weeks. However, this tendency was reversed by 8 weeks, suggesting that the initial increase in cartilage maturation in Mif+/+ constructs deteriorated by 8 weeks. Since the Mif+/+ constructs included more iNOS-positive inflammatory macrophages at 2 weeks, MIF might induce an M1 macrophage-polarized environment, which may eventually worsen the maturation of tissue-engineered cartilage in the long term.
[Mh] Termos MeSH primário: Comunicação Celular
Condrócitos/metabolismo
Cartilagem da Orelha/metabolismo
Oxirredutases Intramoleculares/metabolismo
Fatores Inibidores da Migração de Macrófagos/metabolismo
Macrófagos/metabolismo
Engenharia Tecidual/métodos
[Mh] Termos MeSH secundário: Animais
Proliferação Celular
Condrócitos/transplante
Condrogênese
Técnicas de Cocultura
Colágeno/metabolismo
Cartilagem da Orelha/citologia
Cartilagem da Orelha/transplante
Géis
Seres Humanos
Oxirredutases Intramoleculares/deficiência
Oxirredutases Intramoleculares/genética
Fatores Inibidores da Migração de Macrófagos/deficiência
Fatores Inibidores da Migração de Macrófagos/genética
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Óxido Nítrico Sintase Tipo II/metabolismo
Fenótipo
Poliésteres/química
Células RAW 264.7
Transdução de Sinais
Fatores de Tempo
Tecidos Suporte
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gels); 0 (Macrophage Migration-Inhibitory Factors); 0 (Polyesters); 0 (atelocollagen); 459TN2L5F5 (poly(lactide)); 9007-34-5 (Collagen); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.13.39 (Nos2 protein, mouse); EC 5.3.- (Intramolecular Oxidoreductases); EC 5.3.2.1 (MIF protein, human); EC 5.3.2.1 (Mif protein, mouse)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1002/jcp.26036


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[PMID]:29078705
[Au] Autor:Chiu LLY; Giardini-Rosa R; Weber JF; Cushing SL; Waldman SD
[Ad] Endereço:1 Department of Chemical Engineering, Ryerson University, Toronto, Canada.
[Ti] Título:Comparisons of Auricular Cartilage Tissues from Different Species.
[So] Source:Ann Otol Rhinol Laryngol;126(12):819-828, 2017 Dec.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Tissue engineering of auricular cartilage has great potential in providing readily available materials for reconstructive surgeries. As the field of tissue engineering moves forward to developing human tissues, there needs to be an interspecies comparison of the native auricular cartilage in order to determine a suitable animal model to assess the performance of engineered auricular cartilage in vivo. METHODS: Here, we performed interspecies comparisons of auricular cartilage by comparing tissue microstructure, protein localization, biochemical composition, and mechanical properties of auricular cartilage tissues from rat, rabbit, pig, cow, and human. RESULTS: Human, pig, and cow auricular cartilage have smaller lacunae compared to rat and rabbit cartilage ( P < .05). Despite differences in tissue microstructure, human auricular cartilage has similar biochemical composition to both rat and rabbit. Auricular cartilage from pig and cow, alternatively, display significantly higher glycosaminoglycan and collagen contents compared to human, rat, and rabbit ( P < .05). The mechanical properties of human auricular cartilage were comparable to that of all 4 animal species. CONCLUSIONS: This is the first study that compares the microstructural, biochemical, and mechanical properties of auricular cartilage from different species. This study showed that different experimental animal models of human auricular cartilage may be suitable in different cases.
[Mh] Termos MeSH primário: Cartilagem da Orelha
[Mh] Termos MeSH secundário: Animais
Bovinos
Cartilagem da Orelha/anatomia & histologia
Cartilagem da Orelha/metabolismo
Cartilagem da Orelha/fisiologia
Seres Humanos
Modelos Animais
Coelhos
Ratos
Suínos
Engenharia Tecidual
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417738789


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[PMID]:29069021
[Au] Autor:Mydlak A; Soldacki D; Foroncewicz B; Stopa Z; Powala A; Budlewski T; Paczek L; Mucha K
[Ad] Endereço:aDepartment of Cranio-Maxillofacial Surgery, Oral Surgery and Implantology, Medical University of Warsaw bDepartment of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw cDepartment of Pathology, Medical University of Warsaw dNuclear Medicine Unit, Department of Diagnostic Radiology, Central Clinical Hospital Ministry of Internal Affairs eInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland.
[Ti] Título:Relapsing polychondritis in a liver transplant recipient: A case report.
[So] Source:Medicine (Baltimore);96(43):e8360, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Relapsing polychondritis (RP) is a multisystemic, progressive disease of unknown etiology characterized by recurrent inflammation and progressive cartilage destruction. It can involve all types of cartilage including ears and nose, tracheobronchial tree, joints, and any other tissue rich in proteoglycans such as heart, eyes, and blood vessels. Recurrent chondritis can be life-threatening if the respiratory tract, heart valves, or blood vessels are affected. To date there is no data in the literature on the post solid organ transplantation RP. PATIENT CONCERNS: We present a 59-year-old male liver transplant recipient with primary sclerosing cholangitis who developed RP of the earlobes and nose despite post-transplant immunosuppression. DIAGNOSES: Based on the clinical criteria, scintigraphy and biopsy from the left auricle his condition was diagnosed as RP. INTERVENTIONS: Pulses of methylprednisolone followed by high-dose oral steroids along with azathioprine were administered. OUTCOMES: Such therapy diminished local cartilage inflammation, improved patient's general condition and the laboratory results. Significant loss of ear cartilage and characteristic "saddlenose" were observed after remission of acute symptoms. The control scintigraphy proved very good treatment response. LESSONS: To the best of our knowledge this is the first report on the RP in liver transplant recipient. Based on our patient presentation, we suggest that RP should be suspected in any transplant recipient with cartilage inflammation, and that the Michet's clinical criteria and scintigraphy seem to be the best diagnostic tools for solid organ transplant recipients suspected of RP.
[Mh] Termos MeSH primário: Otopatias/etiologia
Transplante de Fígado/efeitos adversos
Doenças Nasais/etiologia
Policondrite Recidivante/etiologia
[Mh] Termos MeSH secundário: Colangite Esclerosante/cirurgia
Cartilagem da Orelha/patologia
Otopatias/patologia
Seres Humanos
Masculino
Meia-Idade
Cartilagens Nasais/patologia
Doenças Nasais/patologia
Policondrite Recidivante/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008360


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[PMID]:29045420
[Au] Autor:Zhang QS; Kurpad DS; Mahoney MG; Steinbeck MJ; Freeman TA
[Ad] Endereço:Department of Orthopaedic Surgery, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, United States of America.
[Ti] Título:Inhibition of apoptosis signal-regulating kinase 1 alters the wound epidermis and enhances auricular cartilage regeneration.
[So] Source:PLoS One;12(10):e0185803, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Why regeneration does not occur in mammals remains elusive. In lower vertebrates, epimorphic regeneration of the limb is directed by the wound epidermis, which controls blastema formation to promote regrowth of the appendage. Herein, we report that knockout (KO) or inhibition of Apoptosis Signal-regulated Kinase-1 (ASK1), also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5), after full thickness ear punch in mice prolongs keratinocyte activation within the wound epidermis and promotes regeneration of auricular cartilage. Histological analysis showed the ASK1 KO ears displayed enhanced protein markers associated with blastema formation, hole closure and regeneration of auricular cartilage. At seven days after punch, the wound epidermis morphology was markedly different in the KO, showing a thickened stratum corneum with rounded cell morphology and a reduction of both the granular cell layer and decreased expression of filament aggregating protein. In addition, cytokeratin 6 was expressed in the stratum spinosum and granulosum. Topical application of inhibitors of ASK1 (NQDI-1), the upstream ASK1 activator, calcium activated mitogen kinase 2 (KN93), or the downstream target, c-Jun N-terminal kinase (SP600125) also resulted in enhanced regeneration; whereas inhibition of the other downstream target, the p38 α/ß isoforms, (SB203580) had no effect. The results of this investigation indicate ASK1 inhibition prolongs keratinocyte and blastemal cell activation leading to ear regeneration.
[Mh] Termos MeSH primário: Cartilagem da Orelha/patologia
Epiderme/patologia
MAP Quinase Quinase Quinase 5/antagonistas & inibidores
Regeneração
Ferimentos e Lesões/patologia
[Mh] Termos MeSH secundário: Animais
Aporfinas/farmacologia
Membrana Basal/efeitos dos fármacos
Membrana Basal/metabolismo
Biomarcadores/metabolismo
Proteína Quinase Tipo 2 Dependente de Cálcio-Calmodulina/metabolismo
Diferenciação Celular/efeitos dos fármacos
Cartilagem da Orelha/efeitos dos fármacos
Epiderme/efeitos dos fármacos
Epitélio/patologia
Isoenzimas/metabolismo
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Queratinócitos/efeitos dos fármacos
Queratinócitos/patologia
MAP Quinase Quinase Quinase 5/metabolismo
Camundongos Endogâmicos C57BL
Camundongos Knockout
Quinolinas/farmacologia
Regeneração/efeitos dos fármacos
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2,7-dioxo-2,7-dihydro-3H-naphtho(1,2,3-de)quinoline-1-carboxylate); 0 (Aporphines); 0 (Biomarkers); 0 (Isoenzymes); 0 (Quinolines); EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 2); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 2.7.11.25 (MAP Kinase Kinase Kinase 5); EC 2.7.11.25 (Map3k5 protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185803


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[PMID]:29019876
[Au] Autor:Motozawa N; Nakamura T; Takagi S; Fujihara M; Hirami Y; Ishida K; Sotozono C; Kurimoto Y
[Ad] Endereço:aDepartment of Ophthalmology, Kobe City Medical Center General Hospital bDepartment of Ophthalmology, Institute of Biomedical Research and Innovation Hospital, Kobe cDepartment of Frontier Medical Science and Technology for Ophthalmology dDepartment of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
[Ti] Título:Unique circumferential peripheral keratitis in relapsing polychondritis: A case report.
[So] Source:Medicine (Baltimore);96(41):e7951, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Relapsing polychondritis (RP) is a rare collagen disease characterized by inflammation and destruction of cartilage throughout the body. The paper details the clinical course of a case of RP with unique circumferential peripheral keratitis. PATIENT CONCERNS: A 54-year-old Japanese woman was referred to the hospital presenting with auricular and ocular pain. DIAGNOSES: Based on the auricle biopsy results and the three presenting symptoms (bilateral auricular chondritis, inflammatory arthritis and ocular inflammation), her condition was diagnosed as RP. INTERVENTIONS: The three presenting symptoms gradually improved with prednisolone (PSL), methylprednisolone and cyclophosphamide combination therapy, followed by PSL, methotrexate and infliximab combination therapy. However, one month after the initial visit, despite ongoing treatment, a unique circumferential peripheral keratitis suddenly occurred, in which the corneal infiltration gradually clumped together and shrank at the peripheral area. The eye and ear pain showed exacerbations and remissions on reducing the dosage of steroid drugs. The general condition was improved on altering systemic therapy to PSL, methotrexate and tocilizumab. OUTCOMES: Keratitis gradually disappeared within 10 months of the initial visit. LESSONS: This is the first report of a case of RP causing unique circumferential peripheral keratitis. This keratitis occurred despite use of focal and systemic steroids and showed improvement with general recovery. This may indicate that stabilization of general condition is important for recovery from keratitis in RP.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/administração & dosagem
Artrite
Ciclofosfamida/administração & dosagem
Infliximab/administração & dosagem
Ceratite
Policondrite Recidivante
Prednisolona/administração & dosagem
[Mh] Termos MeSH secundário: Antirreumáticos/administração & dosagem
Artrite/etiologia
Artrite/patologia
Técnicas de Diagnóstico Oftalmológico
Monitoramento de Medicamentos/métodos
Quimioterapia Combinada/métodos
Cartilagem da Orelha/patologia
Feminino
Seres Humanos
Ceratite/tratamento farmacológico
Ceratite/etiologia
Ceratite/patologia
Ceratite/fisiopatologia
Metotrexato/administração & dosagem
Meia-Idade
Policondrite Recidivante/complicações
Policondrite Recidivante/diagnóstico
Policondrite Recidivante/tratamento farmacológico
Policondrite Recidivante/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Humanized); 0 (Antirheumatic Agents); 8N3DW7272P (Cyclophosphamide); 9PHQ9Y1OLM (Prednisolone); B72HH48FLU (Infliximab); I031V2H011 (tocilizumab); YL5FZ2Y5U1 (Methotrexate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171012
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007951


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[PMID]:28846132
[Au] Autor:Riedler KL; Shokrani A; Markarian A; Fisher LM; Pepper JP
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angeles, California, U.S.A.
[Ti] Título:Age-related histologic and biochemical changes in auricular and septal cartilage.
[So] Source:Laryngoscope;127(11):E399-E407, 2017 Nov.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES/HYPOTHESIS: To characterize the histologic and biochemical properties of auricular and septal cartilage and analyze age-related changes in middle-aged to older adults. STUDY DESIGN: Cross-sectional study of auricular and septal cartilage from 33 fresh cadavers. METHODS: Auricular and septal cartilage specimens were stained using Safranin O for glycosaminoglycans, Verhoeff's stain for elastin, and Masson's trichrome for collagen. Percentage of tissue stained, cell density and size were quantified. Relationships between donor characteristics and histologic properties were evaluated using mixed model analyses. RESULTS: The average donor age was 75 years (standard deviation = 11 years; range, 55-93 years). In auricular cartilage, each 1-year increase in age was associated with a 0.97% decrease in glycosaminoglycans (P < .001) and a 0.98% decrease in elastin (P < .001). In septal cartilage, glycosaminoglycans decreased 2.4% per year (P < .001). Age did not affect collagen content significantly in auricular (P = .417) or septal cartilage (P = .284). Cell density and cell size declined with age in auricular (both P < .001) and septal cartilage (P = .044, P = .032, respectively). Compared to septal cartilage in patients of all ages, auricular cartilage had more glycosaminoglycans, less collagen, higher cell density, and smaller cells. CONCLUSIONS: In auricular and septal cartilage, glycosaminoglycans, elastin, cell density, and cell size decrease significantly with age in patients over 55 years of age. Glycosaminoglycan content declines faster with age in septal cartilage than auricular cartilage. These age-related changes may affect biomechanical properties and tissue viability, and thereby have implications for graft choice in functional, aesthetic, and reconstructive nasal surgery. LEVEL OF EVIDENCE: NA. Laryngoscope, 127:E399-E407, 2017.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Cartilagem da Orelha/patologia
Cartilagens Nasais/patologia
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Cadáver
Estudos Transversais
Cartilagem da Orelha/metabolismo
Glicosaminoglicanos/metabolismo
Seres Humanos
Meia-Idade
Cartilagens Nasais/metabolismo
Coloração e Rotulagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosaminoglycans)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26807


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[PMID]:28844147
[Au] Autor:Ho TT; Cochran T; Sykes KJ; Humphrey CD; Kriet JD
[Ad] Endereço:1 Department of Otolaryngology, University of Kansas Health System, Kansas City, Kansas, USA.
[Ti] Título:Costal and Auricular Cartilage Grafts for Nasal Reconstruction: An Anatomic Analysis.
[So] Source:Ann Otol Rhinol Laryngol;126(10):706-711, 2017 Oct.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The aim of this study was to measure the length, width, and surface area of costal and auricular cartilage harvested for grafting in rhinoplasty and nasal reconstruction. We also compared the sizes of ear cartilage grafts harvested from the anterior and posterior approaches. METHODS: Fifty-eight nasal reconstructive surgeries requiring rib or ear cartilage were performed by 2 facial plastic surgeons from February 2015 through January 2016. Among the 57 cases that met inclusion criteria, they comprised of 33 costal cartilage grafts and 24 auricular cartilage grafts (17 via anterior approach and 7 via posterior approach). RESULTS: The mean length, width, and surface area for the auricular cartilage grafts were 3.39 cm, 1.22 cm, and 4.38 cm , respectively. The mean length, width, and surface area of the costal cartilage grafts were 4.21 cm, 1.46 cm, and 17.87 cm , respectively. The differences in length, width, and surface area between the anterior versus posterior approach groups were all statistically significant. CONCLUSIONS: In our study, ear cartilage grafts harvested from the posterior approach had significantly greater length, width, and surface area. While this analysis has several limitations, it sets quantitative norms for costal and auricular cartilage harvest that can aid in surgical planning.
[Mh] Termos MeSH primário: Cartilagem Costal/anatomia & histologia
Cartilagem Costal/transplante
Cartilagem da Orelha/anatomia & histologia
Cartilagem da Orelha/transplante
Rinoplastia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417727549


  9 / 1404 MEDLINE  
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[PMID]:28585463
[Au] Autor:Wick CC; Arnaoutakis D; Kaul VF; Isaacson B
[Ad] Endereço:1 Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
[Ti] Título:Endoscopic Lateral Cartilage Graft Tympanoplasty.
[So] Source:Otolaryngol Head Neck Surg;157(4):683-689, 2017 Oct.
[Is] ISSN:1097-6817
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective To describe a novel technique for lateral graft tympanoplasty. Study Design Case series with chart review. Setting Tertiary care university hospital. Subjects and Methods Pediatric and adult patients with tympanic membrane perforations deemed unfavorable for a medial graft technique due to the perforation characteristics or myringitis. Results Between 2014 and 2016, 34 ears from 31 patients underwent a transcanal endoscopic lateral cartilage graft tympanoplasty. The mean age was 24.4 years (range, 6-71 years), and 22 patients (65%) were younger than 18 years. All patients had tympanic membrane perforations. Eighteen patients (53%) had total or near-total perforations, leaving a minimal anterior remnant, and 16 patients (47%) had extensive myringitis. A bisected tragal cartilage-perichondrium shield graft was used in 33 patients (97%). The mean (SD) follow-up length was 9.8 (5.7) months. Initial perforation closure rate was 88.2% (30/34). Three of the persistent perforations underwent a revision endoscopic medial graft tympanoplasty with successful closure, leaving a final closure rate of 97.1% (33/34). Five patients (15%) required topical therapy for postoperative myringitis. Mean (SD) pure-tone average and air-bone gap significantly improved by 11.5 (10.7) dB ( P < .001) and 11.4 (10.6) dB ( P < .001), respectively. Twenty-seven patients (79%) closed their air-bone gap within 20 dB. Conclusion Transcanal endoscopic lateral cartilage graft tympanoplasty is feasible, and initial data support favorable outcomes. Further data are necessary for evaluation of long-term results and efficacy comparisons.
[Mh] Termos MeSH primário: Cartilagem da Orelha/transplante
Endoscopia/métodos
Audição/fisiologia
Perfuração da Membrana Timpânica/cirurgia
Timpanoplastia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Audiometria
Criança
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
Perfuração da Membrana Timpânica/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1177/0194599817709436


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[PMID]:28574946
[Au] Autor:Kreutzer C; Hoehne J; Gubisch W; Rezaeian F; Haack S
[Ad] Endereço:Stuttgart, Germany; and Zurich, Switzerland From the Department of Facial Plastic Surgery, Marienhospital Stuttgart; and the Department of Plastic Surgery and Hand Surgery, University Hospital of Zurich.
[Ti] Título:Free Diced Cartilage: A New Application of Diced Cartilage Grafts in Primary and Secondary Rhinoplasty.
[So] Source:Plast Reconstr Surg;140(3):461-470, 2017 Sep.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Irregularities or deformities of the nasal dorsum after hump reduction account for a significant number of revision rhinoplasties. The authors therefore developed a technique of meticulously dicing and exactly placing free diced cartilage grafts, harvested from septum, rib, or ear cartilage. The cartilage paste is used for smoothening, augmentation, or camouflaging of the nasal dorsum in primary or revision rhinoplasties. METHODS: A retrospective analysis of multisurgeon consecutive open approach rhinoplasties from January to December of 2014 was conducted at a single center. The authors compared the outcome of three different techniques to augment or cover the nasal dorsum after an observation period of 7 months. In group I, 325 patients with free diced cartilage grafts as the only onlay were included. In group II, consisting of 73 patients, the dorsal onlay was either fascia alone or in combination with free diced cartilage grafts. Forty-eight patients in group III received a dorsal augmentation with the classic diced cartilage in fascia technique. RESULTS: Four hundred forty-six patients undergoing primary and secondary rhinoplasties in which one of the above-mentioned diced cartilage techniques was used were included in the study. The authors found revision rates for dorsal irregularities within the 7-month postoperative observation period of 5.2, 8.2, and 25 percent for groups I, II, and III, respectively. CONCLUSION: The authors' findings strongly support their clinical experience that the free diced cartilage graft technique presents an effective and easily reproducible method for camouflage and augmentation in aesthetic and reconstructive rhinoplasty.
[Mh] Termos MeSH primário: Cartilagem/transplante
Rinoplastia/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Cartilagem da Orelha/cirurgia
Estética
Fáscia/transplante
Feminino
Seres Humanos
Masculino
Meia-Idade
Nariz/cirurgia
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003622



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