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[PMID]: 29433463 [Au] Autor: Todokoro D; Hoshino J; Yo A; Makimura K; Hirato J; Akiyama H [Ad] Endereço: Department of Ophthalmology, Gunma University Graduate School of Medicine, 3-39-15 Showa-machi, Maebashi, Gunma, 371-8511, Japan. dtodokor@gunma-u.ac.jp. [Ti] Título: Scedosporium apiospermum infectious scleritis following posterior subtenon triamcinolone acetonide injection: a case report and literature review. [So] Source: BMC Ophthalmol;18(1):40, 2018 Feb 13. [Is] ISSN: 1471-2415 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Ubiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection. CASE PRESENTATION: A 75-year-old man received a posterior STTA injection to treat macular edema in his left eye. After 3 months, he complained of ocular pain and hyperemia in his left eye. Examination showed a subtenon abscess in the site corresponding with the STTA injection. After incising the abscess, the smear revealed numerous conidia-like structures. Although we suspected fungal infection and started topical voriconazole (VRCZ) and levofloxacin, the inflammation of the eye worsened. Fungal culture revealed filamentous fungus growth. Subsequently, we added systemic VRCZ and performed surgical debridement of the infected sclera and Tenon's capsule. Pathology of the sclera showed fungal hyphae. The antifungal susceptibility test revealed low minimum inhibitory concentrations for micafungin, VRCZ and miconazole (0.06, 0.25 and 0.5 µg/mL, respectively). After 2 months, the ciliary injection subsided and VRCZ therapy was stopped. However, subtenon abscess recurred 1 month after discontinuation of topical VRCZ. Surgical debridement and topical VRCZ were resumed, with the eye finally improving after 5 months of management. The fungal species was identified as Scedosporium apiospermum sensu stricto morphologically and by DNA sequencing. CONCLUSIONS: This case was successfully treated by topical and systemic VRCZ and repeated surgical debridement. Infectious scleritis caused by SASC rarely develops after posterior STTA. SASC can produce conidia in the enclosed subtenon space. Late-onset infectious scleritis after a posterior STTA injection suggests the presence of a fungal infection, including SASC, thereby requiring extensive and prolonged medical and surgical treatment. [Mh] Termos MeSH primário: Infecções Oculares Fúngicas/microbiologia Imunossupressores/administração & dosagem Micoses/microbiologia Complicações Pós-Operatórias Scedosporium/isolamento & purificação Esclerite/microbiologia Triancinolona Acetonida/administração & dosagem [Mh] Termos MeSH secundário: Idoso Antifúngicos/uso terapêutico Terapia Combinada Desbridamento Infecções Oculares Fúngicas/diagnóstico Infecções Oculares Fúngicas/terapia Seres Humanos Injeções Intraoculares Edema Macular/tratamento farmacológico Imagem por Ressonância Magnética Masculino Testes de Sensibilidade Microbiana Micoses/diagnóstico Micoses/terapia Esclerite/diagnóstico Esclerite/terapia Cápsula de Tenon/efeitos dos fármacos Voriconazol/uso terapêutico [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antifungal Agents); 0 (Immunosuppressive Agents); F446C597KA (Triamcinolone Acetonide); JFU09I87TR (Voriconazole) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180218 [Lr] Data última revisão: 180218 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180214 [St] Status: MEDLINE [do] DOI: 10.1186/s12886-018-0707-4

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[PMID]: 28724831 [Au] Autor: Murthy SR [Ad] Endereço: Sankara Eye Hospital, Varthur Main Road, Kundlahalli Gate, Bengaluru, Karnataka, India. [Ti] Título: No split, no tenotomy transposition procedure for complete abducens palsy. [So] Source: Indian J Ophthalmol;65(7):636-638, 2017 Jul. [Is] ISSN: 1998-3689 [Cp] País de publicação: India [La] Idioma: eng [Ab] Resumo: Abducens palsy is one of the commonly encountered cranial nerve palsies in strabismus clinic. For large-angle esotropia, due to complete abducens palsies, various vertical recti transposition (VRT) procedures have been described. Hummelsheim and Jensen's procedure are especially popular among them. Risk of anterior segment ischemia and induced vertical deviation postVRT prompt to search for better procedures to correct the esotropia and also improve the abduction. Modified Nishida's procedure (no split, no tenotomy transposition) is one of the newly described procedure in this direction. We describe three cases of complete abducens nerve palsy treated by this procedure. [Mh] Termos MeSH primário: Doenças do Nervo Abducente/complicações Esotropia/cirurgia Movimentos Oculares Músculos Oculomotores/cirurgia Procedimentos Cirúrgicos Oftalmológicos/métodos Visão Binocular/fisiologia [Mh] Termos MeSH secundário: Doenças do Nervo Abducente/diagnóstico Doenças do Nervo Abducente/fisiopatologia Criança Esotropia/etiologia Esotropia/fisiopatologia Feminino Seres Humanos Músculos Oculomotores/fisiopatologia Cápsula de Tenon [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171109 [Lr] Data última revisão: 171109 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170721 [St] Status: MEDLINE [do] DOI: 10.4103/ijo.IJO_768_16

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[PMID]: 28687852 [Au] Autor: Ohno-Matsui K; Fang Y; Morohoshi K; Jonas JB [Ad] Endereço: Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, Japan. [Ti] Título: Optical Coherence Tomographic Imaging of Posterior Episclera and Tenon's Capsule. [So] Source: Invest Ophthalmol Vis Sci;58(9):3389-3394, 2017 Jul 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: To investigate structural features of the posterior episclera and Tenon's capsule in patients with high myopia. Methods: This hospital-based observational study included highly myopic eyes (myopic refractive error > -8 diopters or axial length ≥26.5 mm) in which the posterior sclera in its full thickness could be visualized on swept-source optical coherence tomography (OCT) images in all 12 radial scans centered on the fovea. We assessed the posterior episclera and Tenon's capsule. Results: The study included 278 eyes of 175 patients (mean age, 60.9 ± 11.4 years; range, 32-89 years; axial length, 30.7 ± 1.9 mm; range, 26.5-36.6 mm). The episclera was detected outside of the sclera in 164 eyes (59.0%) and appeared as a relatively uniform structure with a reflectivity slightly lower than scleral reflectivity. In these eyes, mean scleral thickness was 197 ± 73 µm in the foveal region and 164 ± 64 µm and 146 ± 59 µm at 1000 and 2500 µm temporal to the fovea, respectively. The posterior episclera was visualized in the region temporal to the fovea. Mean episcleral thickness detected in 77 eyes was 80 ± 27 µm and 82 ± 30 µm at 1000 µm and 2500 µm temporal to the fovea, respectively. Tenon's capsule was detected in 11 of the 278 eyes (4.0%) as structurally, loosely connected tissue with a meshwork-like appearance. The measured thickness in four eyes was 60 ± 32 µm. In 25 eyes with extremely thin sclera (<100 µm at 1000 µm temporal to the foveola), the mean thickness of the sclera and episclera were 87 ± 11 µm and 65 ± 15 µm, respectively. Conclusions: Swept-source OCT applied to a subset of highly myopic eyes with significant thinning of the retina and choroid allowed visualization of the posterior sclera and episclera, and in some cases, also Tenon's capsule. [Mh] Termos MeSH primário: Miopia Degenerativa/patologia Esclera/patologia Cápsula de Tenon/patologia [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Vasos Sanguíneos/diagnóstico por imagem Feminino Seres Humanos Masculino Meia-Idade Miopia Degenerativa/diagnóstico por imagem Esclera/diagnóstico por imagem Cápsula de Tenon/diagnóstico por imagem Tomografia de Coerência Óptica/métodos [Pt] Tipo de publicação: JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170714 [Lr] Data última revisão: 170714 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170709 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.16-21394

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[PMID]: 28586796 [Au] Autor: Sahay P; Rao A; Padhy D; Sarangi S; Das G; Reddy MM; Modak R [Ad] Endereço: Hyderabad Eye Research Foundation (HERF), LV Prasad Eye Institute, Patia, Bhubaneswar, Odisha, India 2KIIT School of Biotechnology, Patia, Bhubaneswar, Odisha, India. [Ti] Título: Functional Activity of Matrix Metalloproteinases 2 and 9 in Tears of Patients With Glaucoma. [So] Source: Invest Ophthalmol Vis Sci;58(6):BIO106-BIO113, 2017 May 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: To evaluate the differential expression of tear matrix metalloproteinases (MMP) 2 and 9 in of patients with various forms of glaucoma. Methods: Tear samples were collected with a Schirmer's strip from 148 eyes of 113 patients (medically naïve patients with primary open-angle [POAG] or angle closure glaucoma [PACG] and those with pseudoexfoliation syndrome [PXF] or glaucoma [PXG]). These were compared to patients undergoing cataract surgery (controls) for this cross-sectional study. Functional activities of tear MMP-9 and MMP-2 were analyzed by gelatin zymography. Tenon's capsules (n = 15) were harvested from the inferior quadrant in those undergoing cataract surgery and protein expression of MMP-9 was analyzed by immunohistochemistry (IHC). Hydrogen peroxide (H2O2) stress-induced effects on in vitro activities of MMP-9 in human trabecular meshwork (HTM) cells were analyzed. Results: The MMP-9 activity in tears was increased significantly in POAG, (n = 27), PACG (n = 24), and PXF (n = 40) eyes compared to controls (n = 35), and was increased significantly in eyes with glaucoma compared to moderate/severe glaucoma (P < 0.001). The MMP-9 expression was significantly lower in PXG (n = 22) eyes. Immunohistochemistry of Tenon's capsule revealed increased expression of MMP-9 in primary glaucoma eyes. Increased MMP-9 activity was seen in in vitro by gelatin zymography and was confirmed by Western and immunofluorescent assay on HTM upon 800 and 1000 µM H2O2-induced stress for 2 to 3 hours with approximately 80% cell death. Conclusions: Increased tear MMP-9 activity in early glaucoma and pseudoexfoliation syndrome suggesting activation of extracellular matrix (ECM) degradation can be used as a tear-based predictive biomarker. Decreased expression in advanced stages suggests exhaustion of the degradation response. [Mh] Termos MeSH primário: Glaucoma/enzimologia Metaloproteinase 2 da Matriz/metabolismo Metaloproteinase 9 da Matriz/metabolismo Lágrimas/enzimologia [Mh] Termos MeSH secundário: Idoso Análise de Variância Western Blotting Estudos de Casos e Controles Estudos Transversais Síndrome de Exfoliação/enzimologia Feminino Seres Humanos Imuno-Histoquímica Masculino Meia-Idade Cápsula de Tenon/enzimologia Malha Trabecular/enzimologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.35 (Matrix Metalloproteinase 9) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170718 [Lr] Data última revisão: 170718 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170607 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.17-21723

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[PMID]: 28369000 [Au] Autor: Komae K; Takamoto M; Tanaka R; Aihara M; Ohtomo K; Okinaga K; Matsuda J; Nakahara H; Fujino Y; Kaburaki T [Ad] Endereço: *Department of Ophthalmology, University of Tokyo School of Medicine †Department of Ophthalmology, Japan Community Health Care Organization Tokyo Shinjuku Center, Tokyo, Japan. [Ti] Título: Initial Trabeculectomy With Mitomycin-C for Secondary Glaucoma-associated With Uveitis in Behçet Disease Patients. [So] Source: J Glaucoma;26(7):603-607, 2017 Jul. [Is] ISSN: 1536-481X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PURPOSE: To examine clinical outcomes following an initial trabeculectomy with mitomycin-C for secondary glaucoma associated with uveitis in Behçet disease (BD) patients. DESIGN: Retrospective interventional case series. PATIENTS AND METHODS: Twenty-two eyes in 18 patients with uveitic glaucoma (UG) associated with Behçet disease who underwent an initial trabeculectomy with mitomycin-C between January 1996 and August 2014 were retrospectively reviewed. The main outcome measures were intraocular pressure (IOP) control, persistence of a filtering bleb, incidence of postoperative complications, and preopertaive and postoperative frequency of uveitic attacks. We analyzed persistence rates using Kaplan-Meier life tables based on 3 definitions of target IOP control (≤21, ≤18, ≤15 mm Hg) and filtering bleb persistence. RESULT: The persistence rates of postoperative IOP at ≤21, ≤18, and ≤15 mm Hg at 5 years after surgery were 76.1%, 71.5%, and 68.1%, respectively, whereas that of a filtering bleb was 54.4%. Hypotony as a postoperative complication was observed in 4 (18.2%) cases. No significant difference was observed between the preoperative and postoperative frequency of uveitic attacks (1.36±1.15 vs. 0.95±1.49 times/y, P=0.16). There was 1 case in which recurrence of uveitis after surgery caused a loss of filtering bleb, which required a reoperation. CONCLUSIONS: At 5 years after surgery, the persistence rate of postoperative IOP control (≤21 mm Hg) was 76.1% and that of a filtering bleb was 54.4%. The frequency of uveitis recurrence did not significantly increase after surgery. Attention must be paid to avoid such recurrence to maintain the filtering bleb. [Mh] Termos MeSH primário: Alquilantes/administração & dosagem Glaucoma/cirurgia Mitomicina/administração & dosagem Trabeculectomia/métodos Uveíte/cirurgia [Mh] Termos MeSH secundário: Adulto Síndrome de Behçet/complicações Terapia Combinada Túnica Conjuntiva/efeitos dos fármacos Feminino Glaucoma/etiologia Glaucoma/fisiopatologia Seres Humanos Pressão Intraocular/fisiologia Masculino Meia-Idade Complicações Pós-Operatórias/cirurgia Período Pós-Operatório Estudos Retrospectivos Fatores de Risco Cápsula de Tenon/efeitos dos fármacos Tonometria Ocular/efeitos adversos Uveíte/etiologia Uveíte/fisiopatologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Alkylating Agents); 50SG953SK6 (Mitomycin) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171024 [Lr] Data última revisão: 171024 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170404 [St] Status: MEDLINE [do] DOI: 10.1097/IJG.0000000000000665

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[PMID]: 28324879 [Au] Autor: Jovanovic S; Sarenac Vulovic T; Radotic F; Toncic Z; Zivkovic M; Petrovic N [Ad] Endereço: Department of Ophthalmology, Clinical Center Kragujevac, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia. [Ti] Título: Quantitative Analysis of Uveitis Macular Edema in Multiple Sclerosis Patients Receiving Deep Posterior Sub-Tenon Triamcinolone Acetonide Injection. [So] Source: Ophthalmic Res;58(1):1-7, 2017. [Is] ISSN: 1423-0259 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: AIM: We aimed to analyze the effects of adjunctive posterior sub-Tenon capsule triamcinolone acetonide injection in the treatment of intermediate uveitis macular edema in multiple sclerosis patients that could not be controlled by systemic corticosteroid medications and immunomodulators. METHODS: The study included 30 eyes of 25 patients with multiple sclerosis who received a posterior sub-Tenon injection of 40 mg/mL triamcinolone acetonide. Parameters monitored for therapy efficiency were best-corrected visual acuity, intraocular pressure, central foveal thickness (CFT), and fluorescein angiography (FA) scores. RESULTS: Mean best-corrected visual acuity was significantly improved at the control visit 0.15 ± 0.10 versus baseline 0.40 ± 0.20 logMAR (p < 0.05). Six eyes showed intraocular pressure spikes requiring topical antiglaucomatous treatment. Mean CFT and FA scores were significantly decreased versus baseline (CFT: 345 ± 50 µm; FA score: 3.4 ± 1.0) compared with the 12-week control visit (CFT: 219 ± 35 µm; FA score: 1.6 ± 1.1; p < 0.001). CONCLUSION: Posterior sub-Tenon injection of triamcinolone acetonide significantly improved visual acuity and decrease macular edema in patients with intermediate uveitis associated with multiple sclerosis. [Mh] Termos MeSH primário: Fóvea Central/patologia Edema Macular/tratamento farmacológico Esclerose Múltipla/complicações Triancinolona Acetonida/administração & dosagem Uveíte Intermediária/complicações [Mh] Termos MeSH secundário: Adolescente Adulto Idoso Relação Dose-Resposta a Droga Feminino Angiofluoresceinografia Seguimentos Fundo de Olho Glucocorticoides/administração & dosagem Seres Humanos Injeções Intraoculares Edema Macular/diagnóstico Edema Macular/etiologia Masculino Meia-Idade Esclerose Múltipla/diagnóstico Estudos Retrospectivos Cápsula de Tenon Fatores de Tempo Resultado do Tratamento Uveíte Intermediária/diagnóstico Uveíte Intermediária/tratamento farmacológico Acuidade Visual Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Glucocorticoids); F446C597KA (Triamcinolone Acetonide) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170901 [Lr] Data última revisão: 170901 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170322 [St] Status: MEDLINE [do] DOI: 10.1159/000458157

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[PMID]: 28273314 [Au] Autor: Shi H; Wang H; Fu S; Xu K; Zhang X; Xiao Y; Ye W [Ad] Endereço: Department of Ophthalmology, Huashan Hospital, Fudan University, Shanghai, China. [Ti] Título: Losartan Attenuates Scar Formation in Filtering Bleb After Trabeculectomy. [So] Source: Invest Ophthalmol Vis Sci;58(3):1478-1486, 2017 Mar 01. [Is] ISSN: 1552-5783 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Purpose: To examine the effects of losartan on scar formation after trabeculectomy and on fibrotic changes of human Tenon's fibroblasts (HTFs). Methods: Trabeculectomy was performed on New Zealand rabbits. They were randomized to receive one of the following treatments: 0.9% normal saline, mitomycin-C, or one of the three doses of losartan. Bleb morphology, IOP, and histopathology examination were performed. Primary cultured HTFs were treated with losartan or vehicle, with or without angiotensin II (Ang II). Cell proliferation was assessed by Cell Counting Kit-8 assay, and cell migration was detected by scratch wound and transwell assay. Transdifferentiation was evaluated through the expression of α-smooth muscle actin (α-SMA) by immunofluorescence, real-time PCR, and Western blot. The expression of fibronectin (FN) was evaluated by real-time PCR and Western blot. Results: An amount of 5 mg/mL of losartan subconjunctival injection significantly decreased IOP postoperatively and attenuated wound healing of the filtering bleb in the rabbit model. Immunostaining results showed less myofibroblast and collagen deposition around the bleb area in the losartan-treated eyes. Losartan (10-5 M) in vitro significantly attenuated Ang II's stimulatory effects on proliferation and migration of HTFs. Expressions of α-SMA and FN in these cells were also decreased by losartan pretreatment. Conclusions: Losartan attenuates scar formation of filtering bleb after trabeculectomy likely via decreasing proliferation, migration, transdifferentiation, and extracellular matrix deposition of Tenon's fibroblasts. These results indicate that losartan may be an effective therapeutic agent in preventing bleb scar formation and in improving surgical outcome after trabeculectomy. [Mh] Termos MeSH primário: Cicatriz/tratamento farmacológico Glaucoma/cirurgia Losartan/administração & dosagem Complicações Pós-Operatórias/tratamento farmacológico Trabeculectomia/efeitos adversos [Mh] Termos MeSH secundário: Actinas/genética Actinas/metabolismo Idoso Bloqueadores do Receptor Tipo 1 de Angiotensina II/administração & dosagem Animais Western Blotting Movimento Celular Proliferação Celular Células Cultivadas Cicatriz/diagnóstico Cicatriz/etiologia Modelos Animais de Doenças Feminino Fibroblastos/efeitos dos fármacos Fibroblastos/metabolismo Fibroblastos/patologia Regulação da Expressão Gênica Glaucoma/patologia Glaucoma/fisiopatologia Seres Humanos Pressão Intraocular Masculino Meia-Idade Complicações Pós-Operatórias/diagnóstico Complicações Pós-Operatórias/etiologia RNA/genética Coelhos Reação em Cadeia da Polimerase em Tempo Real Cápsula de Tenon/metabolismo Cápsula de Tenon/patologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (ACTA2 protein, human); 0 (Actins); 0 (Angiotensin II Type 1 Receptor Blockers); 63231-63-0 (RNA); JMS50MPO89 (Losartan) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170626 [Lr] Data última revisão: 170626 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170309 [St] Status: MEDLINE [do] DOI: 10.1167/iovs.16-21163

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[PMID]: 28100482 [Au] Autor: Pakravan M; Esfandiari H; Yazdani S; Douzandeh A; Amouhashemi N; Yaseri M; Pakravan P [Ad] Endereço: Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [Ti] Título: Mitomycin C-augmented trabeculectomy: subtenon injection versus soaked sponges: a randomised clinical trial. [So] Source: Br J Ophthalmol;101(9):1275-1280, 2017 Sep. [Is] ISSN: 1468-2079 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND/AIMS: To compare the efficacy and safety of subtenon injection of mitomycin C (MMC) with that of conventional application of MMC-soaked sponges in trabeculectomy. METHODS: In this multicentre randomised clinical trial, 80 consecutive open-angle glaucoma cases were randomised into two groups; group 1 received a subtenon injection of 0.1 mL of 0.01% MMC, while group 2 received 0.02% MMC-soaked sponges. Primary outcome measure was intraocular pressure (IOP), and secondary outcome measures were endothelial cell count (ECC) changes and bleb morphology according to the Indiana Bleb Appearance Grading Scale. Outcome measures were compared at 1, 3 and 6 months postoperatively. Complete and qualified success was defined as IOP within 6-15 mm Hg without and with medications at month 6, respectively. RESULTS: Mean preoperative IOP was 21.8±5.1 in group 1, which reduced to 10.3±3.7 mm Hg at final visit (p<0.001). Corresponding values for group 2 were 21.8±5 and 10.8±3.5 mm Hg respectively (p<0.001). Complete success was 82.5% in both groups, and qualified success was 0 and 2.5% in groups 1 and 2, respectively. (p=0.316) The blebs tended to be more diffuse, less vascularised and shallower in group 1, at month 6 (p=0.45,<0.001 and <0.007 respectively). ECCs did not change significantly at final visit (p=0.813). CONCLUSIONS: Subtenon injection of MMC is a safe and effective alternative to the conventional soaked sponge method. This method produces more favourable bleb morphology after trabeculectomy. TRIAL REGISTRATION NUMBER: NCT02385370, Post-results. [Mh] Termos MeSH primário: Alquilantes/administração & dosagem Glaucoma de Ângulo Aberto/terapia Injeções Intraoculares Mitomicina/administração & dosagem Tampões de Gaze Cirúrgicos Trabeculectomia/métodos [Mh] Termos MeSH secundário: Adulto Idoso Idoso de 80 Anos ou mais Método Duplo-Cego Feminino Seguimentos Glaucoma de Ângulo Aberto/tratamento farmacológico Glaucoma de Ângulo Aberto/cirurgia Seres Humanos Pressão Intraocular/fisiologia Masculino Meia-Idade Estudos Prospectivos Cápsula de Tenon/efeitos dos fármacos Tonometria Ocular Resultado do Tratamento Acuidade Visual/fisiologia [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL [Nm] Nome de substância: 0 (Alkylating Agents); 50SG953SK6 (Mitomycin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170904 [Lr] Data última revisão: 170904 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170120 [St] Status: MEDLINE [do] DOI: 10.1136/bjophthalmol-2016-309671

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[PMID]: 28081465 [Au] Autor: Wang Y; Wang J; Wei LJ; Zhu DM; Zhang JS [Ad] Endereço: Department of Ophthalmology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China; Department of Ophthalmology, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, 450000, China. [Ti] Título: Biological function and mechanism of lncRNA-MEG3 in Tenon's capsule fibroblasts proliferation: By MEG3-Nrf2 protein interaction. [So] Source: Biomed Pharmacother;87:548-554, 2017 Mar. [Is] ISSN: 1950-6007 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: OBJECTIVE: The proliferation of Tenon's capsule fibroblasts after glaucoma filtration surgery is a harmful element for operation failure. However, the underlying mechanism remains unclear. In this study, we evaluated the role of long non-coding RNA (lncRNA)-MEG3 in the proliferation of Glaucoma Tenon's capsule fibroblasts (GTFs) with a model of transforming growth factor-ß (TGF-ß)-induced proliferation which has been used in previous studies to explore the mechanism underlying glaucoma surgery failure. METHODS: In vitro cell proliferation model was made by TGF-ß2 (5ng/mL)-stimulated GTFs obtained from patients with glaucoma filtration surgery, and cell viability and cell proliferation was assessed by MTT assay and [3H] thymidine incorporation assay respectively. Relative expression of MEG3 and Nrf2 mRNA was determined by quantitative real-time PCR. Nrf2 protein level was detected by western blot. Functional interaction between MEG3 and Nrf2 was examined by RNA pull down and RNA Binding Protein Immunoprecipitation (RIP). RESULTS: As detected in isolated Tenon's capsule fibroblasts, expression level of both MEG3 and Nrf2 is decreased in GTFs compared with control fibroblasts (HTFs). Adenovirus mediated overexpression of MEG3 attenuates cell ability and cell proliferation, as well as contributed to upregulation of Nrf2 protein in TGF-ß2-stimualted GTFs. MEG3 positively affects the expression of Nrf2 protein rather than Nrf2 mRNA. We found that this functional interaction of them depends on MEG3-Nrf2 protein formation by RNA pull down and RIP analysis and also is proved to be involved in TGF-ß2-induced cell proliferation. CONCLUSION: The above data suggested that the functional interaction between lncRNA-MEG3 and Nrf2 constitutes the mechanism by which TGF-ß2 induces Tenon's capsule fibroblasts proliferation after glaucoma filtration surgery via the direct binding of MEG3 to Nrf2. [Mh] Termos MeSH primário: Proliferação Celular/genética Fibroblastos/metabolismo Fator 2 Relacionado a NF-E2/genética Domínios e Motivos de Interação entre Proteínas/genética RNA Longo não Codificante/genética Cápsula de Tenon/metabolismo [Mh] Termos MeSH secundário: Linhagem Celular Feminino Glaucoma/genética Glaucoma/metabolismo Seres Humanos Masculino Meia-Idade RNA Mensageiro/genética Fator de Crescimento Transformador beta2/genética Regulação para Cima/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (MEG3 non-coding RNA, human); 0 (NF-E2-Related Factor 2); 0 (NFE2L2 protein, human); 0 (RNA, Long Noncoding); 0 (RNA, Messenger); 0 (Transforming Growth Factor beta2) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170710 [Lr] Data última revisão: 170710 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170113 [St] Status: MEDLINE

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MEDLINE

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[PMID]: 27838929 [Au] Autor: Wu X; Jhanji V; Chen H; Lin H; Zhang G; Brelen M; Chen W [Ad] Endereço: a Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong , Shantou , China , and. [Ti] Título: Change in flash visual evoked potentials in New Zealand albino rabbits after sub-tenon's anesthesia. [So] Source: Cutan Ocul Toxicol;36(2):118-124, 2017 Jun. [Is] ISSN: 1556-9535 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: CONTEXT: The occurrence of amaurosis during ophthalmic anesthesia is well known. The reason for this manifestation has not been studied. PURPOSE: To investigate the effect of sub-tenon's anesthesia on visual conduction in rabbit eyes. METHODS: Fifteen right eyes of 15 New Zealand albino rabbits were included. 2% lidocaine hydrochloride and 0.75% bupivacaine hydrochloride (1 ml, 1:1 mixture) was injected in the sub-tenon's space of 8 eyes while the control group (n = 7) was injected with 1 ml physiological saline. Flash visual evoked potentials (FVEP) were performed with Roland reti-scan system before and, 5 min, 15 min, and 5 days after injection. The natural pupillary diameter and minimal pupillary diameter with light reflex were recorded. RESULTS: In the anesthesia group, N1 latency, P1 latency, and P1 amplitude were 17.13 ± 1.13 ms, 28.25 ± 1.83 ms, 13.45 ± 4.36 µv respectively before injection; 21.75 ± 3.06 ms, 29.63 ± 2.67 ms, 7.24 ± 4.64 µv at 5 min after injection; 22.25 ± 1.39 ms, 29.50 ± 2.51 ms, 7.54 ± 4.47 µv at 15 min after injection, and, 17.75 ± 0.71 ms, 28.13 ± 2.42 ms, 13.17 ± 4.08 µv 5 days after injection. When compared with baseline, N1 latency at 5 min and 15 min after injection showed prolongation (p = 0.019 and p = 0.001, respectively). Likewise, P1 amplitude decreased at 5 min and 15 min after injection (p < 0.001, p < 0.001, respectively). Both N1 latency and P1 amplitude recovered 5 days after the injection. Pupillary light reflex (PLR) constriction amplitude was 35.42% and 0.00% before and at 5 min after injection (p = 0.012). After 5 days it recovered to 33.33%. The FVEP and PLR constriction amplitude did not change significantly after injection in the control group. DISCUSSION: Sub-tenon's anesthesia was associated with changes in the FVEP and pupullary light reflex in rabbit eyes in our study. CONCLUSIONS: The data from this study suggested that sub-tenon's anesthesia could reversibly block visual conduction in rabbit's eyes. [Mh] Termos MeSH primário: Anestesia Local/efeitos adversos Anestésicos Locais/efeitos adversos Cegueira/induzido quimicamente Potenciais Evocados Visuais/efeitos dos fármacos Bloqueio Nervoso/efeitos adversos Reflexo Pupilar/efeitos dos fármacos [Mh] Termos MeSH secundário: Anestesia Local/métodos Anestésicos Locais/administração & dosagem Animais Cegueira/fisiopatologia Bupivacaína/administração & dosagem Bupivacaína/efeitos adversos Feminino Injeções Intraoculares Lidocaína/administração & dosagem Lidocaína/efeitos adversos Bloqueio Nervoso/métodos Coelhos Cápsula de Tenon [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anesthetics, Local); 98PI200987 (Lidocaine); Y8335394RO (Bupivacaine) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161115 [St] Status: MEDLINE [do] DOI: 10.1080/15569527.2016.1189929

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