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[PMID]:29364948
[Au] Autor:Sawai A; Tochigi Y; Kavaliova N; Zaboronok A; Warashina Y; Mathis BJ; Mesaki N; Shiraki H; Watanabe K
[Ad] Endereço:Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
[Ti] Título:MRI reveals menstrually-related muscle edema that negatively affects athletic agility in young women.
[So] Source:PLoS One;13(1):e0191022, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: About 10% of Japanese female athletes are afflicted by menstrually-related edema, mainly in the lower limbs, and, with few studies on this problem, the effect on performance remains unclear. OBJECTIVE: To quantitatively evaluate fluid retention in the calf in female students over their menstrual cycle using magnetic resonance imaging (MRI) and to determine the relationship of MRI changes and athletic performance. DESIGN: The menstrual cycle was divided into 5 phases: menstrual, follicular, ovulatory, early luteal, and late luteal with sampling done in either morning (AM) or afternoon (PM) sessions. At each phase, MRI of the calf (7:00-8:00, 14:00-16:00), body composition and hormones (7:00-8:00), and athletic performance (14:00-16:00) were evaluated. PARTICIPANTS: 13 adult healthy Japanese female students with eumenorrhea. RESULTS: Estradiol levels decreased significantly in the menstrual phase and the follicular phase compared to the early luteal phase (P = 0.001, P = 0.024 respectively). Menstrual phase estradiol levels were significantly lower compared to the ovulatory phase (P = 0.015), and the late luteal phase (P = 0.003). Progesterone levels decreased significantly in the menstrual phase and the follicular phase compared to the ovulatory phase (P = 0.012, P = 0.009 respectively), the early luteal phase (both P = 0.007), and the late luteal phase (P = 0.028, P = 0.029 respectively), and it along with a significant decrease in the ovulatory phase compared to the early luteal phase (P = 0.010). AM T2 signals were significantly lower in the menstrual phase compared to the ovulatory phase (P = 0.043) but not other phases. PM T2 signals increased significantly in the menstrual phase compared to the follicular phase (P = 0.003), ovulatory phase (P = 0.009), and the late luteal phase (P = 0.032), and the difference between the AM and PM values increased significantly in the menstrual phase compared to the other 4 phases (P<0.01). A negative correlation between fluid retention and agility was observed. CONCLUSION: In female students fluid retention during the menstrual phase could be a factor that influences athletic agility.
[Mh] Termos MeSH primário: Atletas
Edema/fisiopatologia
Imagem por Ressonância Magnética/métodos
Menstruação
[Mh] Termos MeSH secundário: Adulto
Composição Corporal
Estradiol/sangue
Feminino
Seres Humanos
Japão
Músculo Esquelético/diagnóstico por imagem
Músculo Esquelético/fisiopatologia
Progesterona/sangue
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
4G7DS2Q64Y (Progesterone); 4TI98Z838E (Estradiol)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191022


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[PMID]:29320561
[Au] Autor:Zhao W; Wang X; Sun KH; Zhou L
[Ad] Endereço:Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America.
[Ti] Título:α-smooth muscle actin is not a marker of fibrogenic cell activity in skeletal muscle fibrosis.
[So] Source:PLoS One;13(1):e0191031, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:α-Smooth muscle actin (α-SMA) is used as a marker for a subset of activated fibrogenic cells, myofibroblasts, which are regarded as important effector cells of tissue fibrogenesis. We address whether α-SMA-expressing myofibroblasts are detectable in fibrotic muscles of mdx5cv mice, a mouse model for Duchenne muscular dystrophy (DMD), and whether the α-SMA expression correlates with the fibrogenic function of intramuscular fibrogenic cells. α-SMA immunostaining signal was not detected in collagen I (GFP)-expressing cells in fibrotic muscles of ColI-GFP/mdx5cv mice, but it was readily detected in smooth muscle cells lining intramuscular blood vessel walls. α-SMA expression was detected by quantitative RT-PCR and Western blot in fibrogenic cells sorted from diaphragm and quadriceps muscles of the ColI-GFP/mdx5cv mice. Consistent with the more severe fibrosis in the ColI-GFP/mdx5cv diaphragm, the fibrogenic cells in the diaphragm exerted a stronger fibrogenic function than the fibrogenic cells in the quadriceps as gauged by their extracellular matrix gene expression. However, both gene and protein expression of α-SMA was lower in the diaphragm fibrogenic cells than in the quadriceps fibrogenic cells in the ColI-GFP/mdx5cv mice. We conclude that myofibroblasts are present in fibrotic skeletal muscles, but their expression of α-SMA is not detectable by immunostaining. The level of α-SMA expression by intramuscular fibrogenic cells does not correlate positively with the level of collagen gene expression or the severity of skeletal muscle fibrosis in the mdx5cv mice. α-SMA is not a functional marker of fibrogenic cells in skeletal muscle fibrosis associated with muscular dystrophy.
[Mh] Termos MeSH primário: Actinas/metabolismo
Biomarcadores/metabolismo
Músculo Esquelético/metabolismo
[Mh] Termos MeSH secundário: Animais
Western Blotting
Fibrose
Camundongos
Camundongos Endogâmicos C57BL
Músculo Esquelético/patologia
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Actins); 0 (Biomarkers); 0 (alpha-smooth muscle actin, mouse)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191031


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[PMID]:29278025
[Au] Autor:Kataoka H; Nakano J; Kondo Y; Honda Y; Sakamoto J; Origuchi T; Okita M
[Ad] Endereço:1 Department of Locomotive Rehabilitation Science, Unit of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences , Nagasaki, Japan.
[Ti] Título:The influence of aging on the effectiveness of heat stress in preventing disuse muscle atrophy.
[So] Source:Physiol Int;104(4):316-328, 2017 Dec 01.
[Is] ISSN:2498-602X
[Cp] País de publicação:Hungary
[La] Idioma:eng
[Ab] Resumo:This study examined the aging effect on disuse muscle atrophy prevention using heat stress. Wistar rats aged 7 and 60 weeks were divided into three groups as follows: control, immobilized (Im), and immobilized and heat stressed (ImH). Heat stress was given by immersing the hindlimbs in hot water (42 °C) for 60 min, once in every 3 days and the gastrocnemius (GAS) and soleus (SOL) muscles were extracted after 14 days. Muscle-fiber types were classified using ATPase staining. Heat shock protein 70 (HSP70) was assessed through Western blotting. In GAS muscle of both groups and SOL muscle of 7-week-old rats, the fiber diameter of each muscle type in the ImH group significantly increased compared with that in the Im group. However, this could not be observed in the SOL muscle of the 60-week-old rats. The increased percentage of type-I fibers and variability of types I and II muscle-fiber diameter were evident in the SOL muscle of the 60-week rats. HSP70 was significantly elevated in the ImH group compared with in the Im group in both muscle types of both age groups. Thus, effectiveness of heat stress in the prevention of disuse muscle atrophy appears unsatisfactory in aging muscle fibers.
[Mh] Termos MeSH primário: Envelhecimento
Proteínas de Choque Térmico HSP70/metabolismo
Hipertermia Induzida/métodos
Músculo Esquelético/fisiopatologia
Transtornos Musculares Atróficos/prevenção & controle
Transtornos Musculares Atróficos/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Resposta ao Choque Térmico
Masculino
Fibras Musculares Esqueléticas/patologia
Músculo Esquelético/patologia
Transtornos Musculares Atróficos/diagnóstico
Ratos
Ratos Wistar
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HSP70 Heat-Shock Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171227
[St] Status:MEDLINE
[do] DOI:10.1556/2060.104.2017.4.1


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[PMID]:29175405
[Au] Autor:Yang F; Xie S; Liu J; Wei C; Zhang H; Chen T; Zhang J
[Ad] Endereço:Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, 100101, China; Key Laboratory of Land Surface Pattern and Simulation, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China.
[Ti] Título:Arsenic concentrations and speciation in wild birds from an abandoned realgar mine in China.
[So] Source:Chemosphere;193:777-784, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Birds are at a higher level in the food chain; however, the potential bioaccumulation and biotransformation of arsenic (As) in birds in As mines has rarely been studied. In this study, four passerine bird species (tree sparrow [Passer montanus], light-vented bulbul [Pycnonotus sinensis], Garrulax canorus [Leucodioptron canorus], and magpie [Pica pica]) were collected from an abandoned As mine in China. The highest recorded As concentrations were 4.95 mg/kg and 51.65 mg/kg in muscles and feathers, respectively. Detection using high-performance liquid chromatography inductively coupled plasma mass spectrometry (HPLC-ICP-MS) revealed six As species, including arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA), monomethylarsonic acid (MMA), arsenobetaine (AsB) and arsenocholine (AsC), with the former three species as the dominant (>92%) and the latter three as the minor As species (<6.17%). Further analysis of the selected bird samples using the X-ray absorption near edge structure (XANES) technique revealed the existence of As(III)-tris-glutathione (As(III)-GSH), which can be regarded as equivalent to the non-extractable and unidentified As form in the HPLC-ICP-MS data. Both methods revealed similar patterns of As species in the birds from the As mine, with muscles containing mainly inorganic As and DMA and feathers containing mainly inorganic As. The results of this study contribute to the knowledge regarding As accumulation and speciation in terrestrial organisms.
[Mh] Termos MeSH primário: Arsênico/análise
Arsenicais/análise
Aves
Mineração
[Mh] Termos MeSH secundário: Animais
Arseniatos
Arsênico/química
Arsenitos
Ácido Cacodílico/análise
China
Cromatografia Líquida de Alta Pressão/métodos
Plumas/química
Espectrometria de Massas/métodos
Músculo Esquelético/química
Passeriformes
Sulfetos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arsenates); 0 (Arsenicals); 0 (Arsenites); 0 (Sulfides); 39895-81-3 (arsenocholine); 56320-22-0 (arsenic disulfide); AJ2HL7EU8K (Cacodylic Acid); J37VJ5709S (monomethylarsonic acid); N5509X556J (arsenite); N712M78A8G (Arsenic); N7CIZ75ZPN (arsenic acid); UWC1LS4V3I (arsenobetaine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28869886
[Au] Autor:Kakimoto K; Akutsu K; Nagayoshi H; Konishi Y; Kajimura K; Tsukue N; Yoshino T; Matsumoto F; Nakano T; Tang N; Hayakawa K; Toriba A
[Ad] Endereço:Osaka Institute of Public Health, 1-3-69, Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. Electronic address: knkakimoto@iph.osaka.jp.
[Ti] Título:Persistent organic pollutants in red-crowned cranes (Grus japonensis) from Hokkaido, Japan.
[So] Source:Ecotoxicol Environ Saf;147:367-372, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The red-crowned crane (Grus japonensis) from eastern Hokkaido is classified as a Special Natural Monument in Japan. In this study, we determined the concentrations of persistent organic pollutants (POPs) in red-crowned crane muscle tissues (n = 47). Polychlorinated biphenyls (PCBs) had the highest median concentration (240ng/g lipid weight), followed by dichlorodiphenyltrichloroethane and its metabolites (DDTs) (150ng/g lipid weight), chlordane-related compounds (CHLs) (36ng/g lipid weight), hexachlorobenzene (HCB) (16ng/g lipid weight), hexachlorocyclohexanes (HCHs) (4.4ng/g lipid weight), polybrominated diphenyl ethers (PBDEs) (1.8ng/g lipid weight), and finally, Mirex (1.5ng/g lipid weight). Additionally, a positive correlation was found among POP concentrations. No sex differences beyond body parameters were observed. Additionally, red-crowned cranes exhibited a high enantiomeric excess of (+)-alpha-HCH, with enantiomer fractions varying from 0.51 to 0.87 (average: 0.69).
[Mh] Termos MeSH primário: Aves/metabolismo
Disruptores Endócrinos/análise
Monitoramento Ambiental/métodos
Poluentes Ambientais/análise
Compostos Orgânicos/análise
[Mh] Termos MeSH secundário: Animais
Aves/crescimento & desenvolvimento
Peso Corporal/efeitos dos fármacos
Disruptores Endócrinos/metabolismo
Poluentes Ambientais/metabolismo
Japão
Músculo Esquelético/química
Músculo Esquelético/metabolismo
Compostos Orgânicos/metabolismo
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Environmental Pollutants); 0 (Organic Chemicals)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170905
[St] Status:MEDLINE


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[PMID]:29296106
[Au] Autor:Seifert JG; Brumet A; St Cyr JA
[Ad] Endereço:Movement Science Laboratory, Montana State University, Bozeman, MT USA.
[Ti] Título:The influence of D-ribose ingestion and fitness level on performance and recovery.
[So] Source:J Int Soc Sports Nutr;14:47, 2017.
[Is] ISSN:1550-2783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Skeletal muscle adenosine triphosphate (ATP) levels are severely depleted during and following prolonged high intensity exercise. Recovery from these lower ATP levels can take days, which can affect performance on subsequent days of exercise. Untrained individuals often suffer the stress and consequences of acute, repeated bouts of exercise by not having the ability to perform or recovery sufficiently to exercise on subsequent days. Conversely, trained individuals may be able to recover more quickly due to their enhanced metabolic systems. D-Ribose (DR) has been shown to enhance the recovery in ATP; however, it is not known if recovery and performance can be benefitted with DR ingestion. Therefore, this study was designed to determine what influence DR might have on muscular performance, recovery, and metabolism during and following a multi-day exercise regimen. Methods: The study was a double blind, crossover study in 26 healthy subjects compared 10 g/day of DR to 10 g/day of dextrose (DEX, control). All subjects completed 2 days of loading with either DR or DEX, followed by 3 additional days of supplementation and during these 3 days of supplementation, each subject underwent 60 min of high intensity interval exercise in separate daily sessions, which involved cycling (8 min of exercise at 60% and 2 min at 80% VO max), followed by a 2 min power output (PO) test. Subjects were divided into two groups based on peak VO results, lower VO (LVO ) and higher peak VO (HVO ). Results: Mean and peak PO increased significantly from day 1 to day 3 for the DR trial compared to DEX in the LVO group. Rate of perceived exertion (RPE) and creatine kinase (CK) were significantly lower for DR than DEX in the LVO group. No differences in PO, RPE, heart rate, CK, blood urea nitrogen, or glucose were found between either supplement for the HVO group. Conclusion: DR supplementation in the lower VO max group resulted in maintenance in exercise performance, as well as lower levels of RPE and CK. Unlike no observed benefits with DEX supplementation.
[Mh] Termos MeSH primário: Trifosfato de Adenosina/metabolismo
Limiar Anaeróbio/efeitos dos fármacos
Desempenho Atlético/fisiologia
Suplementos Nutricionais
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/metabolismo
Aptidão Física/fisiologia
Ribose/farmacologia
[Mh] Termos MeSH secundário: Adulto
Limiar Anaeróbio/fisiologia
Estudos Cross-Over
Método Duplo-Cego
Metabolismo Energético/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Fenômenos Fisiológicos da Nutrição Esportiva
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
681HV46001 (Ribose); 8L70Q75FXE (Adenosine Triphosphate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1186/s12970-017-0205-8


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[PMID]:29209154
[Au] Autor:Tinsley GM; Hamm MA; Hurtado AK; Cross AG; Pineda JG; Martin AY; Uribe VA; Palmer TB
[Ad] Endereço:Energy Balance & Body Composition Laboratory, Musculoskeletal Assessment Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Box 43011, Lubbock, TX 79409 USA.
[Ti] Título:Effects of two pre-workout supplements on concentric and eccentric force production during lower body resistance exercise in males and females: a counterbalanced, double-blind, placebo-controlled trial.
[So] Source:J Int Soc Sports Nutr;14:46, 2017.
[Is] ISSN:1550-2783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Pre-workout supplements purportedly enhance feelings of energy, reduce fatigue and improve exercise performance. The purpose of this study was to examine the performance effects of caffeinated and non-caffeinated multi-ingredient pre-workout supplements. Methods: In a counterbalanced, double-blind, placebo-controlled design, eccentric and concentric force production during lower body resistance exercise on a mechanized squat device were assessed after supplement ingestion. Repetitions-in-reserve/RPE and subjective feelings of energy, focus and fatigue were also examined. Twenty-one resistance-trained adults (12 F, 9 M) completed three conditions in random order: caffeinated supplement, non-caffeinated supplement and placebo. Subjects were not informed of the presence of a placebo condition. Thirty minutes after supplement ingestion, a 3-repetition maximum test and 5 sets of 6 repetitions were completed using the squat device. Each repetition involved 4-s eccentric and concentric phases, and the force signal throughout each repetition was sampled from a load cell contained within the squat device. The scaled and filtered force signals were analyzed using customized software. Repeated measures analysis of variance and appropriate follow-up analyses were utilized to compare dependent variables, and relevant effect sizes (d) were calculated. Results: Supplement or placebo ingestion led to similar subjective responses ( > 0.05). Energy (+8 to 44%; d = 0.3 to 0.8) and focus (+8 to 25%; d = 0.3 to 0.5) were acutely increased by supplement or placebo ingestion and decreased as the exercise session progressed. Fatigue was acutely decreased by supplement or placebo ingestion (-7 to 38%; d = -0.1 to -0.6) and increased as the exercise session progressed. Eccentric and concentric forces were unimproved by supplementation during the exercise sets for both sexes. In the non-caffeinated supplement condition only, maximal eccentric force production was lower during sets 3 to 5, as compared to set 1 ( < 0.05). Effect size data indicated that both the caffeinated and non-caffeinated supplements may contribute to small increases in concentric force production in males (+5 to 20%, d = 0.2 to 0.4 relative to placebo), but not females. Conclusions: As compared to placebo, caffeinated and non-caffeinated multi-ingredient pre-workout supplements failed to improve concentric and eccentric force production. In males, effect size data indicate a possible small benefit of supplementation on concentric force production, although this was not statistically significant. When resistance-trained subjects were unaware of the presence of a placebo, resistance exercise performance was similar regardless of whether a placebo or multi-ingredient supplement was ingested.
[Mh] Termos MeSH primário: Cafeína/farmacologia
Suplementos Nutricionais
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/fisiologia
Treinamento de Resistência
[Mh] Termos MeSH secundário: Análise de Variância
Método Duplo-Cego
Fadiga
Feminino
Alimentos Formulados
Seres Humanos
Masculino
Resistência Física/efeitos dos fármacos
Resistência Física/fisiologia
Fatores Sexuais
Fenômenos Fisiológicos da Nutrição Esportiva
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
3G6A5W338E (Caffeine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1186/s12970-017-0203-x


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[PMID]:29200983
[Au] Autor:Roberts J; Zinchenko A; Suckling C; Smith L; Johnstone J; Henselmans M
[Ad] Endereço:Cambridge Centre for Sport and Exercise Sciences, Anglia Ruskin University, East Road, Cambridge, UK.
[Ti] Título:The short-term effect of high versus moderate protein intake on recovery after strength training in resistance-trained individuals.
[So] Source:J Int Soc Sports Nutr;14:44, 2017.
[Is] ISSN:1550-2783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Dietary protein intakes up to 2.9 g.kg .d and protein consumption before and after resistance training may enhance recovery, resulting in hypertrophy and strength gains. However, it remains unclear whether protein quantity or nutrient timing is central to positive adaptations. This study investigated the effect of total dietary protein content, whilst controlling for protein timing, on recovery in resistance trainees. Methods: Fourteen resistance-trained individuals underwent two 10-day isocaloric dietary regimes with a protein content of 1.8 g.kg .d (PRO ) or 2.9 g.kg .d (PRO ) in a randomised, counterbalanced, crossover design. On days 8-10 (T1-T3), participants undertook resistance exercise under controlled conditions, performing 3 sets of squat, bench press and bent-over rows at 80% 1 repetition maximum until volitional exhaustion. Additionally, participants consumed a 0.4 g.kg whey protein concentrate/isolate mix 30 min before and after exercise sessions to standardise protein timing specific to training. Recovery was assessed via daily repetition performance, muscle soreness, bioelectrical impedance phase angle, plasma creatine kinase (CK) and tumor necrosis factor-α (TNF-α). Results: No significant differences were reported between conditions for any of the performance repetition count variables ( > 0.05). However, within PRO only, squat performance total repetition count was significantly lower at T3 (19.7 ± 6.8) compared to T1 (23.0 ± 7.5; = 0.006). Pre and post-exercise CK concentrations significantly increased across test days ( ≤ 0.003), although no differences were reported between conditions. No differences for TNF-α or muscle soreness were reported between dietary conditions. Phase angle was significantly greater at T3 for PRO (8.26 ± 0.82°) compared with PRO (8.08 ± 0.80°; = 0.012). Conclusions: When energy intake and peri-exercise protein intake was controlled for, a short term PRO diet did not improve markers of muscle damage or soreness in comparison to a PRO approach following repeated days of intensive training. Whilst it is therefore likely that moderate protein intakes (1.8 g.kg .d ) may be sufficient for resistance-trained individuals, it is noteworthy that both lower body exercise performance and bioelectrical phase angle were maintained with PRO . Longer term interventions are warranted to determine whether PRO intakes are sufficient during prolonged training periods or when extensive exercise (e.g. training twice daily) is undertaken.
[Mh] Termos MeSH primário: Proteínas na Dieta/administração & dosagem
Proteínas na Dieta/farmacologia
Suplementos Nutricionais
Músculo Esquelético/efeitos dos fármacos
Músculo Esquelético/fisiologia
Treinamento de Resistência
Levantamento de Peso
[Mh] Termos MeSH secundário: Adulto
Estudos Cross-Over
Feminino
Seres Humanos
Masculino
Contração Muscular
Músculo Esquelético/metabolismo
Resistência Física
Fenômenos Fisiológicos da Nutrição Esportiva
Levantamento de Peso/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Dietary Proteins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE
[do] DOI:10.1186/s12970-017-0201-z


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Registro de Ensaios Clínicos
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[PMID]:29200982
[Au] Autor:Hamarsland H; Nordengen AL; Nyvik Aas S; Holte K; Garthe I; Paulsen G; Cotter M; Børsheim E; Benestad HB; Raastad T
[Ad] Endereço:Department of Physical Performance, Norwegian School of Sport Sciences, P.O. Box 4014 Ullevål Stadion, 0806 Oslo, Norway.
[Ti] Título:Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial.
[So] Source:J Int Soc Sports Nutr;14:43, 2017.
[Is] ISSN:1550-2783
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Protein intake is essential to maximally stimulate muscle protein synthesis, and the amino acid leucine seems to possess a superior effect on muscle protein synthesis compared to other amino acids. Native whey has higher leucine content and thus a potentially greater anabolic effect on muscle than regular whey (WPC-80). This study compared the acute anabolic effects of ingesting 2 × 20 g of native whey protein, WPC-80 or milk protein after a resistance exercise session. Methods: 24 young resistance trained men and women took part in this double blind, randomized, partial crossover, controlled study. Participants received either WPC-80 and native whey ( = 10), in a crossover design, or milk ( = 12). Supplements were ingested immediately (20 g) and two hours after (20 g) a bout of heavy-load lower body resistance exercise. Blood samples and muscle biopsies were collected to measure plasma concentrations of amino acids by gas-chromatography mass spectrometry, muscle phosphorylation of p70S6K, 4E-BP1 and eEF-2 by immunoblotting, and mixed muscle protein synthesis by use of [ H ]phenylalanine-infusion, gas-chromatography mass spectrometry and isotope-ratio mass spectrometry. Being the main comparison, differences between native whey and WPC-80 were analysed by a one-way ANOVA and comparisons between the whey supplements and milk were analysed by a two-way ANOVA. Results: Native whey increased blood leucine concentrations more than WPC-80 and milk ( < 0.05). Native whey ingestion induced a greater phosphorylation of p70S6K than milk 180 min after exercise ( = 0.03). Muscle protein synthesis rates increased 1-3 h hours after exercise with WPC-80 (0.119%), and 1-5 h after exercise with native whey (0.112%). Muscle protein synthesis rates were higher 1-5 h after exercise with native whey than with milk (0.112% vs. 0.064, = 0.023). Conclusions: Despite higher-magnitude increases in blood leucine concentrations with native whey, it was not superior to WPC-80 concerning effect on muscle protein synthesis and phosphorylation of p70S6K during a 5-h post-exercise period. Native whey increased phosphorylation of p70S6K and muscle protein synthesis rates to a greater extent than milk during the 5-h post exercise period. Trial registration: This study was retrospectively registered at clinicaltrials.gov as NCT02968888.
[Mh] Termos MeSH primário: Suplementos Nutricionais
Leucina/análise
Músculo Esquelético/efeitos dos fármacos
Treinamento de Resistência
Fenômenos Fisiológicos da Nutrição Esportiva
Proteínas do Soro do Leite/química
Proteínas do Soro do Leite/farmacologia
[Mh] Termos MeSH secundário: Estudos Cross-Over
Método Duplo-Cego
Feminino
Voluntários Saudáveis
Seres Humanos
Leucina/farmacologia
Masculino
Proteínas Musculares/biossíntese
Músculo Esquelético/fisiologia
Biossíntese de Proteínas/efeitos dos fármacos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Muscle Proteins); 0 (Whey Proteins); GMW67QNF9C (Leucine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12970-017-0202-y


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[PMID]:29231002
[Au] Autor:Xia ZY; Zhai XD; Liu BB; Zheng Z; Zhao LL; Mo YN
[Ad] Endereço:School of Forensic Medicine, Henan University of Science and Technology, Luoyang 471003, China.
[Ti] Título:[Relationship between Electrical Conductivity and Decomposition Rate of Rat Postmortem Skeletal Muscle].
[So] Source:Fa Yi Xue Za Zhi;33(1):17-20, 2017 Feb.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To analyze the relationship among electrical conductivity (EC), total volatile basic nitrogen (TVB-N), which is an index of decomposition rate for meat production, and postmortem interval (PMI). To explore the feasibility of EC as an index of cadaveric skeletal muscle decomposition rate and lay the foundation for PMI estimation. METHODS: Healthy Sprague-Dawley rats were sacrificed by cervical vertebrae dislocation and kept at 28 ℃. Muscle of rear limbs was removed at different PMI, homogenized in deionized water and then skeletal extraction liquid of mass concentration 0.1 g/mL was prepared. EC and TVB-N of extraction liquid were separately determined. The correlation between EC ( 1) and TVB-N ( 2) was analyzed, and their regression function was established. The relationship between PMI ( ) and these two parameters were studied, and their regression functions were separately established. RESULTS: The change trends of EC and TVB-N of skeletal extraction liquid at different PMI were almost the same, and there was a linear positive correlation between them. The regression equation was 2=0.14 1-164.91( ²=0.982). EC and TVB-N of skeletal muscle changed significantly with PMI, and the regression functions were =19.38 1³-370.68 1²+2 526.03 1-717.06( ²=0.994), and =2.56 2³-48.39 2²+330.60 2-255.04( ²=0.997), respectively. CONCLUSIONS: EC and TVB-N of rat postmortem skeletal muscle show similar change trends, which can be used as an index for decomposition rate of cadaveric skeletal muscle and provide a method for further study of late PMI estimation.
[Mh] Termos MeSH primário: Condutividade Elétrica
Patologia Legal
Músculo Esquelético/patologia
Mudanças Depois da Morte
[Mh] Termos MeSH secundário: Animais
Autopsia
Nitrogênio
Ratos
Ratos Sprague-Dawley
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
N762921K75 (Nitrogen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.01.004



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