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[PMID]:28459281
[Au] Autor:Hides JA; Walsh JC; Smith MMF; Mendis MD
[Ad] Endereço:Centre for Musculoskeletal Research, Mary MacKillop Institute for Health Research, Australian Catholic University, Brisbane, Australia.
[Ti] Título:Self-Managed Exercises, Fitness and Strength Training, and Multifidus Muscle Size in Elite Footballers.
[So] Source:J Athl Train;52(7):649-655, 2017 Jul.
[Is] ISSN:1938-162X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Low back pain (LBP) and lower limb injuries are common among Australian Football League (AFL) players. Smaller size of 1 key trunk muscle, the lumbar multifidus (MF), has been associated with LBP and injuries in footballers. The size of the MF muscle has been shown to be modifiable with supervised motor-control training programs. Among AFL players, supervised motor-control training has also been shown to reduce the incidence of lower limb injuries and was associated with increased player availability for games. However, the effectiveness of a self-managed MF exercise program is unknown. OBJECTIVE: To investigate the effect of self-managed exercises and fitness and strength training on MF muscle size in AFL players with or without current LBP. DESIGN: Cross-sectional study. SETTING: Professional AFL context. PATIENTS OR OTHER PARTICIPANTS: Complete data were available for 242 players from 6 elite AFL clubs. INTERVENTION(S): Information related to the presence of LBP and history of injury was collected at the start of the preseason. At the end of the preseason, data were collected regarding performance of MF exercises as well as fitness and strength training. Ultrasound imaging of the MF muscle was conducted at the start and end of the preseason. MAIN OUTCOME MEASURE(S): Size of the MF muscles. RESULTS: An interaction effect was found between performance of MF exercises and time (F = 13.89, P ≤ .001). Retention of MF muscle size was greatest in players who practiced the MF exercises during the preseason (F = 4.77, P = .03). Increased adherence to fitness and strength training was associated with retained MF muscle size over the preseason (F = 5.35, P = .02). CONCLUSIONS: Increased adherence to a self-administered MF exercise program and to fitness and strength training was effective in maintaining the size of the MF muscle in the preseason.
[Mh] Termos MeSH primário: Traumatismos em Atletas/prevenção & controle
Terapia por Exercício/métodos
Futebol Americano/fisiologia
Região Lombossacral/fisiologia
Músculos Paraespinais/fisiologia
Treinamento de Resistência/métodos
[Mh] Termos MeSH secundário: Adulto
Austrália
Estudos Transversais
Feminino
Futebol Americano/lesões
Seres Humanos
Dor Lombar/prevenção & controle
Masculino
Ultrassonografia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.4085/1062-6050-52.3.13


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[PMID]:29390372
[Au] Autor:Notani N; Miyazaki M; Yoshiiwa T; Ishihara T; Kanezaki S; Tsumura H
[Ad] Endereço:Department of Orthopaedic Surgery, Faculty of Medicine, Oita University, Oita, Japan.
[Ti] Título:Dynamic paraspinal muscle impingement causing acute hemiplegia after C1 posterior arch laminectomy: A case report.
[So] Source:Medicine (Baltimore);96(50):e9264, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Acute neurological deficits following spinal surgery commonly result from epidural hematoma, surgical trauma, vascular compromise, and graft or hardware impingement, with the cause identified by magnetic resonance imaging (MRI). We present a rare case of dynamic paraspinal muscle impingement after C1 posterior arch laminectomy, which was diagnosed by myelography, with no significant findings on MRI. PATIENT CONCERNS: An 81-year-old, severely obese male, was referred to our department for the treatment of vertebral disease of the lumbar spine. The patient presented with bilateral weakness and numbness of the upper extremities and gait disturbances. Based on MRI, a diagnosis of retro-odontoid pseudotumor was made, and C1 posterior arch laminectomy, in combination with C4 partial laminectomy and C5 to C6 laminoplasty, was performed. On postoperative day 3, the patient's neurological status deteriorated, with right upper extremity and right lower extremity weakness increasing with neck extension. Although there was no evidence of epidural hematoma formation on MRI, obstruction of the flow of contrast medium by an external posterior compression in neck extension at the level of C1 was identified by myelography. Revision surgery was performed and local muscle swelling at the surgical site identified with no hematoma formation. Occiput to C3 fixation, with instrumentation, was performed. OUTCOMES: Muscle strength of the right upper extremity and lower extremities recovered postsurgery, and the patient has continued to improve function 3 years after surgery, with no further neurological episodes. LESSONS: Dynamic paraspinal muscle impingement following C1 laminectomy in a muscular man was diagnosed by myelography, with no significant findings on standard MRI. CONCLUSION: The possibility of dynamic paraspinal muscle impingement should be considered in patients developing acute, progressive, neurological deficits after posterior cervical decompression, with myelography being the imaging method of choice for diagnosis.
[Mh] Termos MeSH primário: Vértebras Cervicais/cirurgia
Hemiplegia/etiologia
Processo Odontoide/cirurgia
Músculos Paraespinais/cirurgia
Complicações Pós-Operatórias/etiologia
Doenças da Medula Espinal/diagnóstico
Doenças da Medula Espinal/cirurgia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Seres Humanos
Laminectomia
Imagem por Ressonância Magnética
Masculino
Mielografia
Procedimentos Neurocirúrgicos
Recuperação de Função Fisiológica
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009264


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[PMID]:29227152
[Au] Autor:Takashima H; Takebayashi T; Ogon I; Yoshimoto M; Morita T; Imamura R; Nakanishi M; Nagahama H; Terashima Y; Yamashita T
[Ad] Endereço:1 Department Orthopaedic Surgery, Sapporo Medical University School of Medicine , Sapporo, Hokkaido , Japan.
[Ti] Título:Analysis of intra and extramyocellular lipids in the multifidus muscle in patients with chronic low back pain using MR spectroscopy.
[So] Source:Br J Radiol;91(1083):20170536, 2018 Feb.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To analyse the intra- (IMCL) and extramyocellular lipids (EMCL) concentration in the multifidus muscle (Mm) using MR spectroscopy (MRS) in patients with low back pain (LBP), and to evaluate the correlation between those lipid concentrations and age, obesity, atrophy of the Mm and LBP intensity. METHODS: 60 LBP patients underwent routine diagnostic MRI of the lumbar spine before undergoing imaging for the study. Body mass index, as an indicator of obesity and visual analogue scale, as an indicator of LBP were also measured. Proton MRS was acquired with a single-voxel point-resolved spectroscopy sequence. Furthermore, the MRS volume of interest for measuring the IMCL and EMCL concentration at L4/5 for the right Mm was determined, and we measured the cross-sectional area of Mm as an indicator of muscle atrophy. RESULTS: Age showed correlation with EMCL concentration (r = 0.314, p = 0.008). The body mass index showed correlation with EMCL concentration (r = 0.358, p = 0.005). The cross-sectional area of Mm showed correlation with EMCL concentration (r = -0.543, p < 0.001). Moreover, the LBP visual analogue scale showed correlation with IMCL concentration (r = 0.367, p = 0.004). CONCLUSION: There were correlations between age, obesity, muscle atrophy, and EMCL concentration in Mm. IMCL concentration in Mm showed a correlation with LBP intensity. This may suggest that IMCL concentration could become an effective objective indicator of chronic LBP intensity. Advances in knowledge: We investigated the characteristics of fat content in Mm with LBP patients. This study was demonstrated the association of the IMCL and EMCL concentration in Mm with various patient parameters.
[Mh] Termos MeSH primário: Metabolismo dos Lipídeos
Dor Lombar/metabolismo
Espectroscopia de Ressonância Magnética/métodos
Músculos Paraespinais/metabolismo
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Feminino
Seres Humanos
Dor Lombar/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Atrofia Muscular/diagnóstico por imagem
Atrofia Muscular/metabolismo
Obesidade/complicações
Músculos Paraespinais/diagnóstico por imagem
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20170536


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[PMID]:28747206
[Au] Autor:Coolen AWM; van IJsselmuiden MN; van Oudheusden AMJ; Veen J; van Eijndhoven HWF; Mol BWJ; Roovers JP; Bongers MY
[Ad] Endereço:Department of Obstetrics and Gynaecology, Máxima Medical Centre Veldhoven, De Run, 4600 5500, MB, Veldhoven, The Netherlands. anne_lotte_coolen@hotmail.com.
[Ti] Título:Laparoscopic sacrocolpopexy versus vaginal sacrospinous fixation for vaginal vault prolapse, a randomized controlled trial: SALTO-2 trial, study protocol.
[So] Source:BMC Womens Health;17(1):52, 2017 07 26.
[Is] ISSN:1472-6874
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Hysterectomy is one of the most performed surgical procedures during lifetime. Almost 10 % of women who have had a hysterectomy because of prolapse symptoms, will visit a gynaecologist for a surgical correction of a vaginal vault prolapse thereafter. Vaginal vault prolapse can be corrected by many different surgical procedures. A Cochrane review comparing abdominal sacrocolpopexy to vaginal sacrospinous fixation considered the open abdominal procedure as the treatment of first choice for prolapse of the vaginal vault, although operation time and hospital stay is longer. Literature also shows that hospital stay and blood loss are less after a laparoscopic sacrocolpopexy compared to the abdominal technique. To date, it is unclear which of these techniques leads to the best operative result and the highest patient satisfaction. Prospective trials comparing vaginal sacrospinous fixation and laparoscopic sacrocolpopexy are lacking. The aim of this randomized trial is to compare the disease specific quality of life of the vaginal sacrospinous fixation and laparoscopic sacrocolpopexy as the treatment of vaginal vault prolapse. METHODS: We will perform a multicentre prospective randomized controlled trial. Women with a post-hysterectomy symptomatic, POP-Q stage ≥2, vaginal vault prolapse will be included. Participants will be randomized to the vaginal sacrospinous fixation group or the laparoscopic sacrocolpopexy group. Primary outcome is disease specific quality of life at 12 months follow-up. Secondary outcome will be the effect of the surgical treatment on prolapse related symptoms, sexual functioning, procedure related morbidity, hospital stay, post-operative recovery, anatomical results using the POP-Q classification after one and 5 years follow-up, type and number of re-interventions, costs and cost-effectiveness. Analysis will be performed according to the intention to treat principle and not as a per protocol analysis. With a power of 90% and a level of 0.05, the calculated sample size necessary is 96 patients. Taking into account 10% attrition, a number of 106 patients (53 in each arm) will be included. DISCUSSION: The SALTO-2 trial is a randomized controlled multicentre trial to evaluate whether the laparoscopic sacrocolpopexy or vaginal sacrospinous fixation is the first-choice surgical treatment in patients with a stage ≥2 vault prolapse. TRIAL REGISTRATION: Netherlands Trial Register (NTR): NTR3977 ; Registered 28 April 2013.
[Mh] Termos MeSH primário: Colposcopia/métodos
Procedimentos Cirúrgicos em Ginecologia/métodos
Histerectomia/efeitos adversos
Laparoscopia/métodos
Prolapso de Órgão Pélvico/cirurgia
Complicações Pós-Operatórias/cirurgia
[Mh] Termos MeSH secundário: Adulto
Protocolos Clínicos
Feminino
Seres Humanos
Tempo de Internação
Meia-Idade
Países Baixos
Músculos Paraespinais/cirurgia
Prolapso de Órgão Pélvico/etiologia
Complicações Pós-Operatórias/etiologia
Estudos Prospectivos
Região Sacrococcígea/cirurgia
Resultado do Tratamento
Vagina/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170728
[St] Status:MEDLINE
[do] DOI:10.1186/s12905-017-0402-2


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[PMID]:29016507
[Au] Autor:Katrikh AZ; Ettarh R; Kahn MA
[Ad] Endereço:Departments of Structural and Cellular Biology, Obstetrics and Gynecology, and Urology, Tulane University School of Medicine, New Orleans, Louisiana; and the Department of Medical Education, California University of Science and Medicine, Colton, California.
[Ti] Título:Cadaveric Nerve and Artery Proximity to Sacrospinous Ligament Fixation Sutures Placed by a Suture-Capturing Device.
[So] Source:Obstet Gynecol;130(5):1033-1038, 2017 Nov.
[Is] ISSN:1873-233X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To simulate sacrospinous ligament fixation on cadaveric specimens, describe the surrounding retroperitoneal anatomy, and estimate the risk to nerves and arteries for the purposes of optimizing safe suture placement. METHODS: Sacrospinous ligament fixation was performed on eight fresh-tissue female cadavers using a Capio ligature capture device. Distances from placed sutures to the following structures were measured: ischial spine; fourth sacral root; pudendal nerve; the nerve to coccygeus muscle; the nerve to levator ani muscle; inferior gluteal artery; and internal pudendal artery. Periligamentous anatomy was examined in an additional 17 embalmed cadaver dissections. RESULTS: Sacrospinous ligament length was not seen to differ significantly between sides. The fourth sacral spinal nerve was seen most commonly associated with the medial third of the ligament, whereas the pudendal nerve and the nerves to coccygeus and levator ani muscles were associated with the lateral third. The inferior gluteal artery was seen leaving the greater sciatic foramen a median 15.8 mm (range 1.8-48.0, CI 14.9-22.3) above the ligament, whereas the internal pudendal artery exited just above the ischial spine. The two sets of sutures were placed 20.5 mm (range 9.2-34.4, CI 19.7-24.7) and 24.8 mm (range 12.4-46.2, CI 24.0-30.0) medial to the ischial spine, respectively. No structures were directly damaged by placed sutures. The nerves to coccygeus and levator ani were closest and arteries farthest from the placed sutures. CONCLUSION: The middle segment of the sacrospinous ligament has the lowest incidence of nerves and arteries associated with it. This study confirms that the nerves supplying the pelvic floor muscles are at a higher risk from entrapment than the pudendal nerve.
[Mh] Termos MeSH primário: Ligamentos/cirurgia
Sacro/cirurgia
Âncoras de Sutura
Técnicas de Sutura/instrumentação
[Mh] Termos MeSH secundário: Artérias/anatomia & histologia
Artérias/cirurgia
Cadáver
Feminino
Seres Humanos
Ligadura/instrumentação
Síndromes de Compressão Nervosa/etiologia
Músculos Paraespinais/anatomia & histologia
Músculos Paraespinais/irrigação sanguínea
Músculos Paraespinais/inervação
Diafragma da Pelve/anatomia & histologia
Diafragma da Pelve/irrigação sanguínea
Diafragma da Pelve/inervação
Nervo Pudendo/cirurgia
Sacro/anatomia & histologia
Sacro/inervação
Âncoras de Sutura/efeitos adversos
Técnicas de Sutura/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1097/AOG.0000000000002324


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[PMID]:28771560
[Au] Autor:Fang X; Zhao Z; Yu H; Li G; Jiang P; Yang Y; Yang R; Yu X
[Ad] Endereço:College of Animal Science, Jilin University, Changchun, People's Republic of China.
[Ti] Título:Comparative genome-wide methylation analysis of longissimus dorsi muscles between Japanese black (Wagyu) and Chinese Red Steppes cattle.
[So] Source:PLoS One;12(8):e0182492, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:DNA methylation is an important epigenetic mechanism involved in expression of genes in many biological processes including muscle growth and development. Its effects on economically important traits are evinced from reported significant differences in meat quality traits between Japanese black (Wagyu) and Chinese Red Steppes cattle, thus presenting a unique model for analyzing the effects of DNA methylation on these traits. In the present study, we performed whole genome DNA methylation analysis in the two breeds by whole genome bisulfite sequencing (WGBS). Overall, 23150 differentially methylated regions (DMRs) were identified which were located in 8596 genes enriched in 9922 GO terms, of which 1046 GO terms were significantly enriched (p<0.05) including lipid translocation (GO: 0034204) and lipid transport (GO: 0015914). KEGG analysis showed that the DMR related genes were distributed among 276 pathways. Correlation analysis found that 331 DMRs were negatively correlated with the expression levels of differentially expressed genes (DEGs) with 21 DMRs located in promoter regions. Our results identified novel candidate DMRs and DEGs correlated with meat quality traits, which will be valuable for future genomic and epigenomic studies of muscle development and for marker assisted selection of meat quality traits.
[Mh] Termos MeSH primário: Metilação de DNA
Estudo de Associação Genômica Ampla/veterinária
Sequenciamento de Nucleotídeos em Larga Escala/veterinária
Análise de Sequência de DNA/veterinária
[Mh] Termos MeSH secundário: Animais
Bovinos
Ilhas de CpG
Epigênese Genética
Genoma
Pradaria
Músculo Esquelético/química
Músculo Esquelético/metabolismo
Músculos Paraespinais/química
Locos de Características Quantitativas
Análise de Sequência de DNA/métodos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182492


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[PMID]:28598294
[Au] Autor:Ntilikina Y; Bahlau D; Garnon J; Schuller S; Walter A; Schaeffer M; Steib JP; Charles YP
[Ad] Endereço:Service de Chirurgie du Rachis, Hôpitaux Universitaires de Strasbourg, Fédération de Médecine Translationnelle (FMTS), Université de Strasbourg, France.
[Ti] Título:Open versus percutaneous instrumentation in thoracolumbar fractures: magnetic resonance imaging comparison of paravertebral muscles after implant removal.
[So] Source:J Neurosurg Spine;27(2):235-241, 2017 Aug.
[Is] ISSN:1547-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE Percutaneous instrumentation in thoracolumbar fractures is intended to decrease paravertebral muscle damage by avoiding dissection. The aim of this study was to compare muscles at instrumented levels in patients who were treated by open or percutaneous surgery. METHODS Twenty-seven patients underwent open instrumentation, and 65 were treated percutaneously. A standardized MRI protocol using axial T1-weighted sequences was performed at a minimum 1-year follow-up after implant removal. Two independent observers measured cross-sectional areas (CSAs, in cm ) and region of interest (ROI) signal intensity (in pixels) of paravertebral muscles by using OsiriX at the fracture level, and at cranial and caudal instrumented pedicle levels. An interobserver comparison was made using the Bland-Altman method. Reference ROI muscle was assessed in the psoas and ROI fat subcutaneously. The ratio ROI-CSA/ROI-fat was compared for patients treated with open versus percutaneous procedures by using a linear mixed model. A linear regression analyzed additional factors: age, sex, body mass index (BMI), Pfirrmann grade of adjacent discs, and duration of instrumentation in situ. RESULTS The interobserver agreement was good for all CSAs. The average CSA for the entire spine was 15.7 cm in the open surgery group and 18.5 cm in the percutaneous group (p = 0.0234). The average ROI-fat and ROI-muscle signal intensities were comparable: 497.1 versus 483.9 pixels for ROI-fat and 120.4 versus 111.7 pixels for ROI-muscle in open versus percutaneous groups. The ROI-CSA varied between 154 and 226 for open, and between 154 and 195 for percutaneous procedures, depending on instrumented levels. A significant difference of the ROI-CSA/ROI-fat ratio (0.4 vs 0.3) was present at fracture levels T12-L1 (p = 0.0329) and at adjacent cranial (p = 0.0139) and caudal (p = 0.0100) instrumented levels. Differences were not significant at thoracic levels. When adjusting based on age, BMI, and Pfirrmann grade, a significant difference between open and percutaneous procedures regarding the ROI-CSA/ROI-fat ratio was present in the lumbar spine (p < 0.01). Sex and duration of instrumentation had no significant influence. CONCLUSIONS Percutaneous instrumentation decreased muscle atrophy compared with open surgery. The MRI signal differences for T-12 and L-1 fractures indicated less fat infiltration within CSAs in patients who received percutaneous treatment. Differences were not evidenced at thoracic levels, where CSAs were smaller. Fat infiltration was not significantly different at lumbar levels with either procedure in elderly patients with associated discopathy and higher BMI. In younger patients, there was less fat infiltration of lumbar paravertebral muscles with percutaneous procedures.
[Mh] Termos MeSH primário: Vértebras Lombares/cirurgia
Imagem por Ressonância Magnética
Procedimentos Ortopédicos/instrumentação
Músculos Paraespinais/diagnóstico por imagem
Fraturas da Coluna Vertebral/cirurgia
Vértebras Torácicas/cirurgia
[Mh] Termos MeSH secundário: Tecido Adiposo/diagnóstico por imagem
Adolescente
Adulto
Fatores Etários
Idoso
Índice de Massa Corporal
Feminino
Seguimentos
Seres Humanos
Vértebras Lombares/diagnóstico por imagem
Masculino
Meia-Idade
Variações Dependentes do Observador
Procedimentos Ortopédicos/métodos
Músculos Paraespinais/cirurgia
Próteses e Implantes
Estudos Retrospectivos
Fatores Sexuais
Fraturas da Coluna Vertebral/diagnóstico por imagem
Vértebras Torácicas/diagnóstico por imagem
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170610
[St] Status:MEDLINE
[do] DOI:10.3171/2017.1.SPINE16886


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[PMID]:28574152
[Au] Autor:Feeney C; Sharp DJ; Hellyer PJ; Jolly AE; Cole JH; Scott G; Baxter D; Jilka S; Ross E; Ham TE; Jenkins PO; Li LM; Gorgoraptis N; Midwinter M; Goldstone AP
[Ad] Endereço:Computational, Cognitive, and Clinical Neuroimaging Laboratory, Division of Brain Sciences, Imperial College London, Hammersmith Hospital, London, United Kingdom.
[Ti] Título:Serum insulin-like growth factor-I levels are associated with improved white matter recovery after traumatic brain injury.
[So] Source:Ann Neurol;82(1):30-43, 2017 Jul.
[Is] ISSN:1531-8249
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Traumatic brain injury (TBI) is a common disabling condition with limited treatment options. Diffusion tensor imaging measures recovery of axonal injury in white matter (WM) tracts after TBI. Growth hormone deficiency (GHD) after TBI may impair axonal and neuropsychological recovery, and serum insulin-like growth factor-I (IGF-I) may mediate this effect. We conducted a longitudinal study to determine the effects of baseline serum IGF-I concentrations on WM tract and neuropsychological recovery after TBI. METHODS: Thirty-nine adults after TBI (84.6% male, median age = 30.5 years, 87.2% moderate-severe, median time since TBI = 16.3 months, n = 4 with GHD) were scanned twice, 13.3 months (range = 12.1-14.9) apart, and 35 healthy controls were scanned once. Symptom and quality of life questionnaires and cognitive assessments were completed at both visits (n = 33). Our main outcome measure was fractional anisotropy (FA), a measure of WM tract integrity, in a priori regions of interest: splenium of corpus callosum (SPCC) and posterior limb of internal capsule (PLIC). RESULTS: At baseline, FA was reduced in many WM tracts including SPCC and PLIC following TBI compared to controls, indicating axonal injury, with longitudinal increases indicating axonal recovery. There was a significantly greater increase in SPCC FA over time in patients with serum IGF-I above versus below the median for age. Only the higher IGF-I group had significant improvements in immediate verbal memory recall over time. INTERPRETATION: WM recovery and memory improvements after TBI were greater in patients with higher serum IGF-I at baseline. These findings suggest that the growth hormone/IGF-I system may be a potential therapeutic target following TBI. Ann Neurol 2017;82:30-43.
[Mh] Termos MeSH primário: Lesões Encefálicas Traumáticas/patologia
Fator de Crescimento Insulin-Like I/metabolismo
Substância Branca/patologia
[Mh] Termos MeSH secundário: Adulto
Anisotropia
Estudos de Casos e Controles
Imagem de Tensor de Difusão
Feminino
Hormônio do Crescimento/deficiência
Seres Humanos
Cápsula Interna/patologia
Estudos Longitudinais
Masculino
Neuroimagem
Testes Neuropsicológicos
Músculos Paraespinais/patologia
Qualidade de Vida
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
67763-96-6 (Insulin-Like Growth Factor I); 9002-72-6 (Growth Hormone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171005
[Lr] Data última revisão:
171005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE
[do] DOI:10.1002/ana.24971


  9 / 364 MEDLINE  
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[PMID]:28498073
[Au] Autor:Thakar S; Kurudi Siddappa A; Aryan S; Mohan D; Sai Kiran NA; Hegde AS
[Ad] Endereço:Department of Neurological Sciences, Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India.
[Ti] Título:Does the mesodermal derangement in Chiari Type I malformation extend to the cervical spine? Evidence from an analytical morphometric study on cervical paraspinal muscles.
[So] Source:J Neurosurg Spine;27(4):421-427, 2017 Oct.
[Is] ISSN:1547-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE The mesodermal derangement in Chiari Type I malformation (CMI) has been postulated to encompass the cervical spine. The objectives of this study were to assess the cross-sectional areas (CSAs) of cervical paraspinal muscles (PSMs) in patients with CMI without syringomyelia, compare them with those in non-CMI subjects, and evaluate their correlations with various factors. METHODS In this retrospective study, the CSAs of cervical PSMs in 25 patients were calculated on T2-weighted axial MR images and computed as ratios with respect to the corresponding vertebral body areas. These values and the cervical taper ratios were then compared with those of age- and sex-matched non-CMI subjects and analyzed with respect to demographic data and clinicoradiological factors. RESULTS Compared with the non-CMI group, the mean CSA values for the rectus capitis minor and all of the subaxial PSMs were lower in the study group, and those of the deep extensors were significantly lower (p = 0.004). The cervical taper ratio was found to be significantly higher in the study cohort (p = 0.0003). A longer duration of symptoms and a steeper cervical taper ratio were independently associated with lower CSA values for the deep extensors (p = 0.04 and p = 0.03, respectively). The presence of neck pain was associated with a lower CSA value for the deep flexors (p = 0.03). CONCLUSIONS Patients with CMI demonstrate alterations in their cervical paraspinal musculature even in the absence of coexistent syringomyelia. Their deep extensor muscles undergo significant atrophic changes that worsen with the duration of their symptoms. This could be related to a significantly steeper cervical taper ratio that their cervical cords are exposed to. Neck pain in these patients is related to atrophy of their deep flexor muscles. A steeper cervical taper ratio and alterations in the PSMs could be additional indicators for surgery in patients with CMI without syringomyelia.
[Mh] Termos MeSH primário: Malformação de Arnold-Chiari/diagnóstico por imagem
Vértebras Cervicais/anormalidades
Vértebras Cervicais/diagnóstico por imagem
Músculos Paraespinais/anormalidades
Músculos Paraespinais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Variações Dependentes do Observador
Tamanho do Órgão
Análise de Regressão
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170513
[St] Status:MEDLINE
[do] DOI:10.3171/2016.12.SPINE16914


  10 / 364 MEDLINE  
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[PMID]:28444241
[Au] Autor:Khayatzadeh S; Kalmanson OA; Schuit D; Havey RM; Voronov LI; Ghanayem AJ; Patwardhan AG
[Ad] Endereço:Musculoskeletal Biomechanics Laboratory, Edward Hines Jr VA Hospital, Hines, Illinois.
[Ti] Título:Cervical Spine Muscle-Tendon Unit Length Differences Between Neutral and Forward Head Postures: Biomechanical Study Using Human Cadaveric Specimens.
[So] Source:Phys Ther;97(7):756-766, 2017 Jul 01.
[Is] ISSN:1538-6724
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: Forward head posture (FHP) may be associated with neck pain and poor health-related quality of life. Literature describes only qualitative muscle length changes associated with FHP. Objective: The purpose of this study was to quantify how muscle-tendon unit lengths are altered when human cadaveric specimens are placed in alignments representing different severities of FHP. Design: This biomechanical study used 13 fresh-frozen cadaveric cervical spine specimens (Occiput-T1, 54±15 y). Methods: Specimens' postural changes simulating increasing FHP severity while maintaining horizontal gaze were assessed. Specimen-specific anatomic models derived from computed tomography-based anatomic data were combined with postural data and specimen-specific anatomy of muscle attachment points to estimate the muscle length changes associated with FHP. Results: Forward head posture was associated with flexion of the mid-lower cervical spine and extension of the upper cervical (sub-occipital) spine. Muscles that insert on the cervical spine and function as flexors (termed "cervical flexors") as well as muscles that insert on the cranium and function as extensors ("occipital extensors") shortened in FHP when compared to neutral posture. In contrast, muscles that insert on the cervical spine and function as extensors ("cervical extensors") as well as muscles that insert on the cranium and function as flexors ("occipital flexors") lengthened. The greatest shortening was seen in the major and minor rectus capitis posterior muscles. These muscles cross the Occiput-C2 segments, which exhibited extension to maintain horizontal gaze. The greatest lengthening was seen in posterior muscles crossing the C4-C6 segments, which exhibited the most flexion. Limitations: This cadaver study did not incorporate the biomechanical influence of active musculature. Conclusions: This study offers a novel way to quantify postural alignment and muscle length changes associated with FHP. Model predictions are consistent with qualitative descriptions in the literature.
[Mh] Termos MeSH primário: Movimentos da Cabeça/fisiologia
Músculos do Pescoço/fisiologia
Músculos Paraespinais/fisiologia
Postura/fisiologia
Músculos Superficiais do Dorso/fisiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Fenômenos Biomecânicos/fisiologia
Cadáver
Vértebras Cervicais/diagnóstico por imagem
Vértebras Cervicais/fisiologia
Simulação por Computador
Feminino
Seres Humanos
Imagem Tridimensional
Masculino
Meia-Idade
Modelos Biológicos
Músculos do Pescoço/diagnóstico por imagem
Cervicalgia/fisiopatologia
Músculos Paraespinais/diagnóstico por imagem
Músculos Superficiais do Dorso/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1093/ptj/pzx040



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