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[PMID]:29499664
[Au] Autor:Kim WJ; Kim MM
[Ad] Endereço:Department of Ophthalmology, Yeungnam University College of Medicine, 170, Hyeonchung-ro, Nam-gu, Daegu, 42415, South Korea.
[Ti] Título:The fast exodrift after the first surgical treatment of exotropia and its correlation with surgical outcome of second surgery.
[So] Source:BMC Ophthalmol;18(1):67, 2018 Mar 02.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To compare the rate of exodrift after a second surgery for recurrent exotropia, in patients grouped to fast versus slow exodrift after their first surgery. To determine whether there is a correlation with surgical outcome, and to evaluate the factors associated with fast exodrift. METHODS: Patients with recurrent intermittent exotropia, who underwent contralateral lateral rectus recession and medial rectus resection as the second surgery and were followed up for 24 months postoperatively between January 1991 and January 2013, were reviewed retrospectively. The patients were divided into two groups according to the rate of exodrift after the first surgery: Group F, patients exhibiting fast exodrift after the first surgery (> 10 prism diopters [PD] before postoperative month 6); and Group S, patients exhibiting slow exodrift after the first surgery (≤10 PD before postoperative month 6). The difference in the clinical course over the 24 months after the second surgery between the two groups and factors associated with fast exodrift were analyzed. RESULTS: In total, 106 patients with recurrent exotropia were enrolled in this study. Of these, 68 (64.2%) and 38 (35.8%) patients were included in group F and S, respectively. Group F showed more exodrift compared with groups S over the 24-month postoperative period; however, there was no significant difference in the clinical course between the two groups during that time (p = 0.54, repeated-measure ANOVA). In logistic analysis, immediate postoperative deviation after the first surgery was associated with fast exodrift (p <  0.001). CONCLUSION: Although patients with recurrent exotropia had shown fast exodrift after the first surgery, no significant difference in the surgical outcome was observed after the second surgery according to the rate of exodrift after the first surgery.
[Mh] Termos MeSH primário: Exotropia/cirurgia
Músculos Oculomotores/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Exotropia/diagnóstico
Exotropia/fisiopatologia
Movimentos Oculares/fisiologia
Feminino
Seguimentos
Seres Humanos
Masculino
Músculos Oculomotores/fisiopatologia
Procedimentos Cirúrgicos Oftalmológicos
Prognóstico
Recidiva
Reoperação
Estudos Retrospectivos
Visão Binocular/fisiologia
Acuidade Visual
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180304
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0722-5


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[PMID]:29482520
[Au] Autor:Rau A; Klopfer M; Rommel N; Rau-Fornefeld M; Kolk A
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Klinikum rechts der Isar, Technische Universität München, Ismaningerstr. 22, D-81675, Munich, Germany. andrea.rau@tum.de.
[Ti] Título:Extraocular muscle repositioning as the last therapeutic option for a patient with a severe course of Graves' Ophthalmopathy: a case report.
[So] Source:BMC Ophthalmol;18(1):56, 2018 Feb 27.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid administration. The inflammatory swelling of the intraorbital muscles can lead to pressure-induced damage of the optic nerve. Orbital decompression surgery is a therapeutic option for these patients with varying success. Other symptoms like the extreme malposition of the ocular globe are poorly addressed by decompression surgery and demand for different therapeutic approaches. CASE PRESENTATION: Presented is the case of a 46-year old patient with an acute exacerbation of Graves' ophthalmopathy. Clinically apparent was a convergent strabismus fixus with severe hypotropia of both eyes. The patient suffered from attacks of heavy retrobulbar pain and eyesight deteriorated dramatically. Since neither systemic glucocorticoid therapy nor orbital decompression surgery had helped to halt the progress of the disease, a decision was made in favour of the surgical release and repositioning of the inferior and medial rectus muscle as a final therapeutic option. Surgery of both eyes was performed consecutively within one week. Detailed descriptions and illustrations of the surgical steps and treatment outcome are provided supplemented by a discussion of the current literature. CONCLUSIONS: Graves' Ophthalmopathy is a variant and therapeutically challenging disease. Exceptional courses of the disease call for therapeutic approaches off the beaten track. Surgical extraocular muscle repositioning, which has not been described before in the context of Graves' Ophthalmopathy, proved to be effective in improving the patient's eyesight and quality of life. Furthermore, we regard the measurement of extraocular muscle volume as a valuable method to monitor the course of Graves' Ophthalmopathy.
[Mh] Termos MeSH primário: Oftalmopatia de Graves/cirurgia
Músculos Oculomotores/cirurgia
Procedimentos Cirúrgicos Oftalmológicos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Estrabismo/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180228
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0718-1


  3 / 12147 MEDLINE  
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[PMID]:29403334
[Au] Autor:Clark J; Randolph J; Sokol JA; Moore NA; Lee HBH; Nunery WR
[Ad] Endereço:Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, Kentucky.
[Ti] Título:Surgical approach to limiting skin contracture following protractor myectomy for essential blepharospasm.
[So] Source:Digit J Ophthalmol;23(4):8-12, 2017.
[Is] ISSN:1542-8958
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose: To report our experience with protractor myectomy in patients with benign essential blepharospasm who did not respond to serial botulinum toxin injection, and to describe intra- and postoperative techniques that limited skin contracture while also providing excellent functional and cosmetic results. Methods: The medical records of patients with isolated, benign, essential blepharospasm who underwent protractor myectomy from 2005 to 2008 by a single surgeon were reviewed retrospectively. The technique entailed operating on a single eyelid during each procedure, using a complete en bloc resection of all orbicularis tissue, leaving all eyelid skin intact at the time of surgery, and placing the lid under stretch with Frost suture and applying a pressure dressing for 5-7 days. Results: Data from 28 eyelids in 7 patients were included. Average follow-up was 21.5 months (range, 4-76 months). Of the 28 eyelids, 20 (71.4%) showed postoperative resolution of spasm, with no further need for botulinum toxin injections. In the 8 eyelids requiring further injections, the average time to injection after surgery was 194 days (range, 78-323 days), and the average number of injections was 12 (range, 2-23 injections). All but one eyelid had excellent cosmetic results, without signs of contracture; one eyelid developed postoperative skin contracture following premature removal of the Frost suture and pressure dressing because of concerns over increased intraocular pressure. Conclusions: In our patient cohort, this modified technique resulted in excellent cosmetic and functional results and limited postoperative skin contracture.
[Mh] Termos MeSH primário: Blefarospasmo/cirurgia
Contratura/cirurgia
Pálpebras/cirurgia
Músculos Oculomotores/cirurgia
Procedimentos Cirúrgicos Oftalmológicos/métodos
Complicações Pós-Operatórias/cirurgia
Dermatopatias/cirurgia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Contratura/diagnóstico
Contratura/etiologia
Pálpebras/patologia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/etiologia
Reoperação
Estudos Retrospectivos
Pele/patologia
Dermatopatias/diagnóstico
Dermatopatias/etiologia
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.5693/djo.01.2016.11.001


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[PMID]:29329570
[Au] Autor:Erdei A; Steiber Z; Molnar C; Berenyi E; Nagy EV
[Ad] Endereço:Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Nagyerdei krt 98, Debrecen, 4032, Hungary. erdeianm@gmail.com.
[Ti] Título:Exophthalmos in a young woman with no graves' disease - a case report of IgG4-related orbitopathy.
[So] Source:BMC Ophthalmol;18(1):5, 2018 Jan 12.
[Is] ISSN:1471-2415
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Immunoglobulin G4-related disease (IgG4-rd) is characterized by lymphoplasmacytic infiltration and tissue fibrosis. Orbital manifestations of IgG4-rd may include unilateral or bilateral proptosis, cicatricial extraocular muscle myopathy, orbital inflammation and pain which may mimic ophthalmic Graves' disease. CASE PRESENTATION: A 25-year-old woman has been referred to the endocrinology clinic, 4 months after delivery, with suspected Graves' orbitopathy. She has had bronchial asthma and recurrent skin rashes of unknown aetiology for the last 10 years and was treated for dacryoadenitis with steroid containing eye drops 5 years ago. During pregnancy she developed eyelid swelling. After delivery, eyelid redness and retrobulbar pain evolved. Proptosis was demonstrated by Hertel's exophthalmometry. Orbital magnetic resonance imaging showed enlarged lateral and superior rectus muscles in both orbits. Thyroid function tests were in the normal range and no thyroid stimulating hormone (TSH) receptor autoantibodies were present. The eye muscle involvement pattern raised suspicion, and the high IgG4 level with positive histology of the lacrimal gland confirmed the diagnosis of immunoglobulin G4-related orbitopathy. Rapid improvement was observed following oral methylprednisolone. CONCLUSIONS: IgG4-related orbitopathy may mimic Graves' orbitopathy. Euthyroid patients with no TSH receptor autoantibodies should be evaluated for immunoglobulin G4-related orbitopathy. Once IgG4-related orbitopathy is proven, other manifestations of IgG4-related disease have to be searched for; lifelong follow-up is warranted.
[Mh] Termos MeSH primário: Anticorpos Anti-Idiotípicos/imunologia
Autoanticorpos/imunologia
Doenças Autoimunes/complicações
Exoftalmia/etiologia
Músculos Oculomotores/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Doenças Autoimunes/diagnóstico
Doenças Autoimunes/imunologia
Diagnóstico Diferencial
Exoftalmia/diagnóstico
Exoftalmia/imunologia
Feminino
Oftalmopatia de Graves
Seres Humanos
Imagem por Ressonância Magnética
Órbita
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Anti-Idiotypic); 0 (Autoantibodies); 0 (anti-IgA)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180114
[St] Status:MEDLINE
[do] DOI:10.1186/s12886-018-0672-y


  5 / 12147 MEDLINE  
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[PMID]:27771241
[Au] Autor:Merino PS; Vera RE; Mariñas LG; Gómez de Liaño PS; Escribano JV
[Ad] Endereço:Ocular Motility Section, Department of Ophthalmology, Hospital General Universitario Gregorio Marañón, Madrid, Spain. Electronic address: pilimerino@gmail.com.
[Ti] Título:Botulinum toxin for treatment of restrictive strabismus.
[So] Source:J Optom;10(3):189-193, 2017 Jul - Sep.
[Is] ISSN:1989-1342
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To study the types of acquired restrictive strabismus treated in a tertiary hospital and the outcome of treatment with botulinum toxin. METHODS: We performed a 10-year retrospective study of patients with restrictive strabismus aged ≥18 years who were treated with botulinum toxin. Treatment was considered successful if the final vertical deviation was ≤5 PD, horizontal deviation ≤10 PD, with no head turn or diplopia. RESULTS: We included 27 cases (mean age, 61.9 years). Horizontal strabismus was diagnosed in 11.1%, vertical in 51.9%, and mixed in 37%. Strabismus was secondary to cataract surgery in 6 cases, high myopia in 6, orbital fractures in 5, retinal surgery in 5, Graves ophthalmopathy in 4, and repair of conjunctival injury in 1 case. Diplopia was diagnosed in all patients, head turn in 33.3%. The initial deviation was 14 PD (range, 2-40), the mean number of injections per patient was 1.6 (range, 1-3), and the mean dose was 9.5 IU (range, 2.5-22.5). At the end of follow-up, diplopia was recorded in 59.3%, head turn in 18.5%, surgical treatment in 51.9%, and need for prism glasses in 14.8%. Outcome was successful in 37% of patients (4 high myopia, 3 orbital fractures, 2 post-surgical retinal detachment, and 1 post-cataract surgery). Mean follow-up was 3±1.8 years. CONCLUSION: Vertical deviation was observed in half of the sample. The most frequent deviation was secondary to cataract surgery and high myopia. Treatment with botulinum toxin was successful in one-third of the patients at the end of follow-up.
[Mh] Termos MeSH primário: Toxinas Botulínicas/administração & dosagem
Movimentos Oculares/fisiologia
Previsões
Estrabismo/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Seres Humanos
Injeções Intramusculares
Masculino
Meia-Idade
Neurotoxinas/administração & dosagem
Músculos Oculomotores
Estudos Retrospectivos
Estrabismo/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neurotoxins); EC 3.4.24.69 (Botulinum Toxins)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  6 / 12147 MEDLINE  
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[PMID]:28451999
[Au] Autor:Devue C; Grimshaw GM
[Ad] Endereço:Cognitive and Affective Neuroscience Lab, School of Psychology, Victoria University of Wellington, PO Box 600, Wellington, 6040, New Zealand. christel.devue@vuw.ac.nz.
[Ti] Título:Faces are special, but facial expressions aren't: Insights from an oculomotor capture paradigm.
[So] Source:Atten Percept Psychophys;79(5):1438-1452, 2017 Jul.
[Is] ISSN:1943-393X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We compared the ability of angry and neutral faces to drive oculomotor behaviour as a test of the widespread claim that emotional information is automatically prioritized when competing for attention. Participants were required to make a saccade to a colour singleton; photos of angry or neutral faces appeared amongst other objects within the array, and were completely irrelevant for the task. Eye-tracking measures indicate that faces drive oculomotor behaviour in a bottom-up fashion; however, angry faces are no more likely to capture the eyes than neutral faces are. Saccade latencies suggest that capture occurrs via reflexive saccades and that the outcome of competition between salient items (colour singletons and faces) may be subject to fluctuations in attentional control. Indeed, although angry and neutral faces captured the eyes reflexively on a portion of trials, participants successfully maintained goal-relevant oculomotor behaviour on a majority of trials. We outline potential cognitive and brain mechanisms underlying oculomotor capture by faces.
[Mh] Termos MeSH primário: Emoções/fisiologia
Movimentos Oculares/fisiologia
Expressão Facial
Músculos Oculomotores/fisiologia
Estimulação Luminosa/métodos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ira/fisiologia
Atenção/fisiologia
Feminino
Seres Humanos
Masculino
Resolução de Problemas/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.3758/s13414-017-1313-x


  7 / 12147 MEDLINE  
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[PMID]:29390531
[Au] Autor:Tu Y; Gao F
[Ad] Endereço:Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China.
[Ti] Título:Dexmedetomidine-based monitored conscious sedation combined local anesthesia for levator resection in a 10-year-old child with Marcus Gunn jaw-winking synkinesis: A case report.
[So] Source:Medicine (Baltimore);96(51):e9369, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Levator resection has become a routine procedure for patients with severe Marcus Gunn jaw-winking synkinesis (MGJWS). To optimize the surgical outcome, adult patients need to be kept awake, or easily aroused and responsive to verbal commands during the operation. However, levator resection is commonly performed under general anesthesia in pediatric patients. In the present case, we described a successful anesthetic protocol of conscious sedation with local anesthesia for levator resection in a child. PATIENT CONCERNS: A 10-year-old boy with MGJWS was admitted to our hospital and scheduled for levator resection. The patient was born through a normal delivery and had no previous history of allergy, no comorbidity, and no history of receiving anesthesia or operation. The laboratory tests of the patient were unremarkable. DIAGNOSES: The diagnosis of MGJWS was made by two experienced ophthalmologists. INTERVENTIONS: A 10-year-old boy with MGJWS was admitted to our hospital and scheduled for levator resection. The levator resection was performed under monitored conscious sedation with dexmedetomidine and local anesthesia. OUTCOMES: Patient with spontaneous breathing responded normally to verbal commands throughout the operation, and no adverse events occurred. The patient and ophthalmologist reported high satisfaction with anesthesia management. LESSONS: Dexmedetomidine-based monitored conscious sedation with local anesthesia is a feasible alternative to general anesthesia for levator resection in collaborative patients.
[Mh] Termos MeSH primário: Blefaroptose/diagnóstico
Blefaroptose/terapia
Dexmedetomidina/administração & dosagem
Cardiopatias Congênitas/diagnóstico
Cardiopatias Congênitas/terapia
Anormalidades Maxilomandibulares/diagnóstico
Anormalidades Maxilomandibulares/terapia
Monitorização Fisiológica/métodos
Doenças do Sistema Nervoso/diagnóstico
Doenças do Sistema Nervoso/terapia
Músculos Oculomotores/cirurgia
[Mh] Termos MeSH secundário: Anestesia Local
Criança
Sedação Consciente/métodos
Seguimentos
Seres Humanos
Masculino
Doenças Raras
Reflexo Anormal
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
67VB76HONO (Dexmedetomidine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009369


  8 / 12147 MEDLINE  
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[PMID]:29193991
[Au] Autor:Sharma M; Hunter DG
[Ad] Endereço:a Department of Ophthalmology , Boston Children's Hospital, Harvard Medical School , Boston , MA , USA.
[Ti] Título:Diplopia after Strabismus Surgery.
[So] Source:Semin Ophthalmol;33(1):102-107, 2018.
[Is] ISSN:1744-5205
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Diplopia is a disappointing and, at times, unanticipated consequence of what might otherwise be considered anatomically successful strabismus surgery. In this study, we review the existing literature regarding diplopia after strabismus surgery in the context of the senior author's experience. We divide postoperative diplopia types into cases that occur in the setting of normal binocular vision (or "normal" suppression) vs. cases that are the consequence of rare or anomalous sensorial adaptations. We then discuss how to identify patients at greatest risk based on history and preoperative testing, and we offer strategies for managing these sometimes-challenging cases.
[Mh] Termos MeSH primário: Diplopia
Músculos Oculomotores/cirurgia
Procedimentos Cirúrgicos Oftalmológicos/efeitos adversos
Complicações Pós-Operatórias
Estrabismo/cirurgia
Visão Binocular
[Mh] Termos MeSH secundário: Diplopia/classificação
Diplopia/etiologia
Diplopia/fisiopatologia
Seres Humanos
Músculos Oculomotores/fisiopatologia
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1080/08820538.2017.1353827


  9 / 12147 MEDLINE  
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[PMID]:29390490
[Au] Autor:Zhu Y; Sun C; Zhang X; Shentu X
[Ad] Endereço:Eye Center, 2nd Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China.
[Ti] Título:Ptosis induced by topical steroid eye drops: Two cases reports.
[So] Source:Medicine (Baltimore);96(51):e9288, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Ptosis is a rare complication of periocular steroid use. Studies report that local injections of steroids produce ptosis. We describe the first 2 cases of ptosis because of long-term treatment with topical steroid eye drops. PATIENT CONCERNS: Two cases admitted to our hospital because of ptosis of their right eye after long-term treatment with topical steroid eye drops. Both of them had uncontrolled Posner-Schlossman syndrome. DIAGNOSIS: Two cases were diagnosed as steroid-related ptosis. INTERVENTIONS: Regulatory anti-inflammation therapy was prescribed for case 1, and after inflammation control, phacoemulsification was done for her. Six months after steroid withdrawal, the levator resection of the right eye was performed. Case 2 refused our advice of steroid reduction and ptosis surgery. OUTCOMES: After surgery, case 1 retained a symmetrical appearance during a 1-year follow-up. In the surgery, we found thin levator muscles and slack levator palpebrae superioris aponeurosis (LPSA) in the affected eye. Postoperative transmission electron microscopy revealed typical signs of apoptosis in levator muscle cells. LESSONS: We suggest topical application of steroids induces levator muscle apoptosis and LPSA weakness, and results in ptosis.
[Mh] Termos MeSH primário: Corticosteroides/efeitos adversos
Blefaroptose/induzido quimicamente
Extração de Catarata/métodos
Músculos Oculomotores/efeitos dos fármacos
Soluções Oftálmicas/efeitos adversos
Facoemulsificação/métodos
[Mh] Termos MeSH secundário: Corticosteroides/uso terapêutico
Adulto
Blefaroplastia/métodos
Blefaroptose/cirurgia
Catarata/diagnóstico
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Cuidados Pós-Operatórios
Medição de Risco
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenal Cortex Hormones); 0 (Ophthalmic Solutions)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009288


  10 / 12147 MEDLINE  
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[PMID]:28459979
[Au] Autor:Whitman MC; Engle EC
[Ad] Endereço:F.M. Kirby Neurobiology Center, Boston Children's Hospital, Boston, MA 02115, USA.
[Ti] Título:Ocular congenital cranial dysinnervation disorders (CCDDs): insights into axon growth and guidance.
[So] Source:Hum Mol Genet;26(R1):R37-R44, 2017 08 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Unraveling the genetics of the paralytic strabismus syndromes known as congenital cranial dysinnervation disorders (CCDDs) is both informing physicians and their patients and broadening our understanding of development of the ocular motor system. Genetic mutations underlying ocular CCDDs alter either motor neuron specification or motor nerve development, and highlight the importance of modulations of cell signaling, cytoskeletal transport, and microtubule dynamics for axon growth and guidance. Here we review recent advances in our understanding of two CCDDs, congenital fibrosis of the extraocular muscles (CFEOM) and Duane retraction syndrome (DRS), and discuss what they have taught us about mechanisms of axon guidance and selective vulnerability. CFEOM presents with congenital ptosis and restricted eye movements, and can be caused by heterozygous missense mutations in the kinesin motor protein KIF21A or in the ß-tubulin isotypes TUBB3 or TUBB2B. CFEOM-causing mutations in these genes alter protein function and result in axon growth and guidance defects. DRS presents with inability to abduct one or both eyes. It can be caused by decreased function of several transcription factors critical for abducens motor neuron identity, including MAFB, or by heterozygous missense mutations in CHN1, which encodes α2-chimaerin, a Rac-GAP GTPase that affects cytoskeletal dynamics. Examination of the orbital innervation in mice lacking Mafb has established that the stereotypical misinnervation of the lateral rectus by fibers of the oculomotor nerve in DRS is secondary to absence of the abducens nerve. Studies of a CHN1 mouse model have begun to elucidate mechanisms of selective vulnerability in the nervous system.
[Mh] Termos MeSH primário: Axônios/fisiologia
Síndrome da Retração Ocular/genética
Fibrose/genética
Oftalmoplegia/genética
[Mh] Termos MeSH secundário: Animais
Axônios/metabolismo
Anormalidades Congênitas
Síndrome da Retração Ocular/metabolismo
Síndrome da Retração Ocular/patologia
Oftalmopatias Hereditárias/genética
Fibrose/metabolismo
Fibrose/patologia
Seres Humanos
Cinesina/genética
Cinesina/metabolismo
Camundongos
Mutação
Mutação de Sentido Incorreto
Transtornos da Motilidade Ocular/genética
Músculos Oculomotores/anormalidades
Músculos Oculomotores/patologia
Oftalmoplegia/metabolismo
Oftalmoplegia/patologia
Crânio/fisiopatologia
Tubulina (Proteína)/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (KIF21A protein, human); 0 (TUBB3 protein, human); 0 (Tubulin); EC 3.6.4.4 (Kinesin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx168



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