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[PMID]:27776448
[Au] Autor:Ye C; Zhang W; Jiang S; Yu Y; Zhou X; Zhu L; Xue D; He R
[Ad] Endereço:a Department of Orthopedic Surgery , the Second Affiliated Hospital, School of Medicine, Zhejiang University , Hangzhou , Zhejiang , China.
[Ti] Título:Platelet-derived growth factor-BB attenuates titanium-particle-induced osteolysis in vivo.
[So] Source:Growth Factors;34(5-6):177-186, 2016 12.
[Is] ISSN:1029-2292
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Inflammation and osteoclastogenesis play critical roles in wear-particle-induced periprosthetic osteolysis (WPO). Platelet-derived growth factor-BB (PDGF-BB) could promote osteogenesis and inhibit inflammatory response. The aim of this study was to investigate the impact of PDGF-BB on WPO. Mice were divided into four groups, namely, sham, vehicle, low-, and high-dose PDGF-BB groups. Mice in the rhPDGF-BB groups were treated with PDGF-BB at 0.25 or 1 mg/ml/kg/day. Mice in the sham and vehicle groups received PBS daily. Two weeks after surgery, calvariae were harvested. Immunohistochemical analysis and µ-CT showed that PDGF-BB significantly reduced osteoclast formation and bone resorption. ELISA showed that rhPDGF-BB decreased the secretion of TNF-α, IL-1ß, and IL-6. Western blotting revealed that rhPDGF-BB stimulated the expression of osteocalcin and osteoprotegerin. Furthermore, more VEGF and CD31 proteins were observed due to PDGF-BB by immunofluorescence. In conclusion, these findings suggest that rhPDGF-BB represents a potential treatment for WPO.
[Mh] Termos MeSH primário: Interface Osso-Implante/patologia
Osteólise/tratamento farmacológico
Proteínas Proto-Oncogênicas c-sis/uso terapêutico
Titânio/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Interleucina-6/genética
Interleucina-6/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Osteólise/etiologia
Molécula-1 de Adesão Celular Endotelial de Plaquetas/genética
Molécula-1 de Adesão Celular Endotelial de Plaquetas/metabolismo
Proteínas Proto-Oncogênicas c-sis/administração & dosagem
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/metabolismo
Fator A de Crescimento do Endotélio Vascular/genética
Fator A de Crescimento do Endotélio Vascular/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Platelet Endothelial Cell Adhesion Molecule-1); 0 (Proto-Oncogene Proteins c-sis); 0 (Tumor Necrosis Factor-alpha); 0 (Vascular Endothelial Growth Factor A); 1B56C968OA (becaplermin); D1JT611TNE (Titanium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1080/08977194.2016.1240680


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[PMID]:29328609
[Au] Autor:Markovic A; Lazic Z; Misic T; Scepanovic M; Todorovic A; Thakare K; Janjic B; Vlahovic Z; Glisic M
[Ti] Título:Effect of surgical drill guide and irrigans temperature on thermal bone changes during drilling implant sites - thermographic analysis on bovine ribs.
[So] Source:Vojnosanit Pregl;73(8):744-50, 2016 Aug.
[Is] ISSN:0042-8450
[Cp] País de publicação:Serbia
[La] Idioma:eng
[Ab] Resumo:Background/Aim: During drilling implant sites, mechanical energy is converted into thermal one resulting in transient rise in temperature of surrounding bone. The temperature of 47°C exeeding one minute impairs osseointegration, compromises mechanical properties of the local bone and could cause early implant failure. This in vitro study aimed to assess the effect of surgical drill guide and temperature of irrigans on thermal changes of the local bone during drilling implant sites, and to test the influence of irrigans temperature on the temperature of surgical drill guide. Methods: A total of 48 specimens obtained from bovine ribs were randomly allocated to four experimental conditions according to the 2 x 2 factorial design: drill guide (with or without) and saline (at 25°C or 5°C). Real-time infrared thermography was used as a method for temperature measurement. The primary outcome was bone temperature change during drilling implant sites measured at 3 osteotomy depths, whereas the second one was change in the temperature of the drill guide. Data were analyzed by Brunner and Langer nonparametric analysis and Wilcoxon test. Results: The effect of drill guide on the changes of bone temperature was significant at the entrance of osteotomy, whereas the effect of saline temperature was significant at all osteotomy levels (p < 0.001). No significant interaction was found (p > 0.05). Guided surgery and irrigation with saline at 25°C were associated with the highest bone temperature increase. Increase in drill guide temperature was significantly higher when saline at 25°C was used (p < 0.001). Conclusion: Guided implant site preparation generates higher temperature of the local bone than conventional drilling, not exceeding the threshold for thermal bone necrosis. Although saline at room temperature provides sufficient heat control during drilling, cooled saline is more effective regardless the use of surgical drill guide.
[Mh] Termos MeSH primário: Temperatura Corporal
Osso e Ossos/fisiologia
Implantes Dentários
Osteotomia/instrumentação
Temperatura Ambiente
Irrigação Terapêutica/métodos
[Mh] Termos MeSH secundário: Animais
Interface Osso-Implante
Bovinos
Masculino
Modelos Animais
Costelas/fisiologia
Costelas/cirurgia
Estresse Mecânico
Termografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Implants)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180113
[St] Status:MEDLINE
[do] DOI:10.2298/VSP141208041M


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[PMID]:28776691
[Au] Autor:Roskies MG; Fang D; Abdallah MN; Charbonneau AM; Cohen N; Jordan JO; Hier MP; Mlynarek A; Tamimi F; Tran SD
[Ad] Endereço:Department of Otolaryngology-Head and Neck Surgery, McGill University, Montreal, Quebec, Canada.
[Ti] Título:Three-dimensionally printed polyetherketoneketone scaffolds with mesenchymal stem cells for the reconstruction of critical-sized mandibular defects.
[So] Source:Laryngoscope;127(11):E392-E398, 2017 Nov.
[Is] ISSN:1531-4995
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Additive manufacturing offers a tailored approach to tissue engineering by providing anatomically precise scaffolds onto which stem cells and growth factors can be supplied. Polyetherketoneketone (PEKK), an ideal candidate biomaterial, is limited by a poor implant-bone interface but can be functionalized with adipose-derived stem cells (ADSC) to promote integration. This in vivo study examined the interaction of a three-dimensional printed PEKK/ADSC implant within the critical-sized mandibular defect in a rabbit model. STUDY DESIGN/METHODS: Trapezoidal porous scaffolds with dimensions of 1.5 × 1.0 × 0.5 cm were printed using selective laser sintering. ADSCs were seeded on the scaffolds that were then implanted in marginal defects created in New Zealand rabbits. Rabbits were euthanized at 10- and 20-week intervals. Microcomputed tomography was used to characterize bone ingrowth and was correlated with histological analysis. Stress testing was performed on the scaffolds before and after implantation. RESULTS: All scaffolds were well integrated into adjacent bone. Bone-to-tissue volume increased from 30.34% ( ± 12.46) to 61.27% ( ± 8.24), and trabecular thickness increased from 0.178 mm ( ± 0.069) to 0.331 mm ( ± 0.0306) in the 10- and 20-week groups, respectively, compared to no bone regrowth on the control side (P < 0.05). Histology confirmed integration at the bone-implant interface. Biomechanical testing revealed a compressive resistance 15 times that of bone alone (P < 0.05) CONCLUSION: 3D-printed PEKK scaffolds combined with ADSCs present a promising solution to improve the bone-implant interface and increase the resistance to forces of mastication after mandibular reconstruction. LEVEL OF EVIDENCE: NA. Laryngoscope, 127:E392-E398, 2017.
[Mh] Termos MeSH primário: Cetonas/farmacologia
Mandíbula/cirurgia
Impressão Tridimensional
Procedimentos Cirúrgicos Reconstrutivos
Tecidos Suporte
[Mh] Termos MeSH secundário: Tecido Adiposo/citologia
Animais
Biomarcadores/análise
Interface Osso-Implante
Diferenciação Celular
Projeto Auxiliado por Computador
Feminino
Mandíbula/diagnóstico por imagem
Células Mesenquimais Estromais/citologia
Osteogênese/fisiologia
Coelhos
Engenharia Tecidual
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Ketones)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.1002/lary.26781


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[PMID]:28552926
[Au] Autor:Bogu VP; Kumar YR; Kumar Khanara A
[Ad] Endereço:Department of Mechanical Engineering, NIT Warangal, Telangana, India.
[Ti] Título:Modelling and structural analysis of skull/cranial implant: beyond mid-line deformities.
[So] Source:Acta Bioeng Biomech;19(1):125-131, 2017.
[Is] ISSN:1509-409X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This computational study explores modelling and finite element study of the implant under Intracranial pressure (ICP) conditions with normal ICP range (7 mm Hg to 15 mm Hg) or increased ICP (>I5 mm Hg). The implant fixation points allow implant behaviour with respect to intracranial pressure conditions. However, increased fixation points lead to variation in deformation and equivalent stress. Finite element analysis is providing a valuable insight to know the deformation and equivalent stress. METHODS: The patient CT data (Computed Tomography) is processed in Mimics software to get the mesh model. The implant is modelled by using modified reverse engineering technique with the help of Rhinoceros software. This modelling method is applicable for all types of defects including those beyond the middle line and multiple ones. It is designed with eight fixation points and ten fixation points to fix an implant. Consequently, the mechanical deformation and equivalent stress (von Mises) are calculated in ANSYS 15 software with distinctive material properties such as Titanium alloy (Ti6Al4V), Polymethyl methacrylate (PMMA) and polyether-ether-ketone (PEEK). RESULTS: The deformation and equivalent stress results are obtained through ANSYS 15 software. It is observed that Ti6Al4V material shows low deformation and PEEK material shows less equivalent stress. Among all materials PEEK shows noticeably good result. CONCLUSIONS: Hence, a concept was established and more clinically relevant results can be expected with implementation of realistic 3D printed model in the future. This will allow physicians to gain knowledge and decrease surgery time with proper planning.
[Mh] Termos MeSH primário: Placas Ósseas
Craniotomia/instrumentação
Modelos Biológicos
Procedimentos Cirúrgicos Reconstrutivos/instrumentação
Crânio/fisiopatologia
Crânio/cirurgia
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/química
Cimentos para Ossos/química
Interface Osso-Implante/fisiopatologia
Simulação por Computador
Craniotomia/métodos
Módulo de Elasticidade
Análise de Falha de Equipamento
Análise de Elementos Finitos
Seres Humanos
Pressão Intracraniana
Cetonas/química
Teste de Materiais
Polietilenoglicóis/química
Polimetil Metacrilato/química
Desenho de Prótese
Procedimentos Cirúrgicos Reconstrutivos/métodos
Estresse Mecânico
Resistência à Tração
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Bone Cements); 0 (Ketones); 30IQX730WE (Polyethylene Glycols); 31694-16-3 (polyetheretherketone); 9011-14-7 (Polymethyl Methacrylate)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28425054
[Au] Autor:Preis M; Bailey T; Marchand LS; Barg A
[Ad] Endereço:Department of Orthopaedics, Aukammklinik, Wiesbaden, Germany.
[Ti] Título:Can a Three-Component Prosthesis be Used for Conversion of Painful Ankle Arthrodesis to Total Ankle Replacement?
[So] Source:Clin Orthop Relat Res;475(9):2283-2294, 2017 Sep.
[Is] ISSN:1528-1132
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In patients with painful ankle arthrodesis, the surgical treatment is challenging, and may include takedown of ankle arthrodesis and conversion to a total ankle replacement (TAR). This procedure is technically demanding given the altered anatomy after arthrodesis. Few studies have evaluated TAR in the setting of prior arthrodesis. QUESTIONS/PURPOSES: (1) What intraoperative and perioperative complications were observed in patients who underwent conversion of an ankle arthrodesis to a TAR? (2) Was durable fixation achieved at short term, and what was the alignment of the components? (3) What subsequent surgical procedures were performed, including revisions? (4) What improvements were observed in pain, tibiotalar range of motion (ROM), and quality of life? METHODS: Between January 2007 and December 2014, 18 patients with a painful ankle arthrodesis underwent conversion to TAR at our tertiary referral center. During this period, the indications for conversion of ankle arthrodesis to TAR were tibiotalar nonunion or malunion after attempted arthrodesis in patients who declined revision ankle arthrodesis. The goal of revision surgery was to help patients regain hindfoot mobility and to decrease pain. During the study period, all patients who met indications were treated with a conversion procedure. Of the 18 patients included, 14 were men and four were women. The mean age of the patients was 51 ± 7 years. The mean followup was 54 ± 27 months, with no loss to follow up observed. The initial ankle arthrodesis was performed 6 ± 3.5 years before conversion to TAR. In all patients, the conversion to TAR was performed using a nonconstrained cementless three-component prosthesis. Intraoperative and postoperative complications, revision procedures, and prosthesis component loosening were evaluated. Weightbearing radiographs were used to determine the angular alignment of the tibial and talar components using α/ß/γ angles and to analyze the bone-implant interface. Osseointegration was defined as visible trabecular structures at the bone-implant interface without radiolucent lines. The criteria for radiographic loosening was defined as subsidence or migration of prosthesis components and/or a cystic lesion with a diameter at least 2 mm. Clinical assessment included pain evaluation, measurement of ankle ROM, and quality of life. RESULTS: Two of the 18 patients sustained an intraoperative medial malleolar fracture. In three patients, delayed wound healing was observed. At latest followup, four patients had incomplete osseointegration (posterior quarter of the bone-prosthesis interface on the tibial side). None of the 18 patients had prosthesis loosening. In all patients, both components were neutrally aligned. Two patients had painful arthrofibrosis with reduced ROM, which we treated with an open arthrolysis and exchange of mobile-bearing inlay; one other patient is considering a revision for substantial tibial component medial tilt with collapse of the medial arch. At the latest followup, the mean dorsiflexion and plantar flexion were 8.5° ± 3° and 15° ± 5°, respectively. The mean visual analog scale (VAS) score decreased from 9 ± 0.8 to 1.7 ± 1.6 (p < 0.001). The Short Form Health Survey questionnaire (SF-36) physical and mental outcome scores improved from 34 ± 5 to 74 ± 11 (p < 0.001) and from 49 ± 4 to 75.5 ± 7 (p < 0.001). CONCLUSIONS: Conversion of an ankle arthrodesis to a TAR is a technically challenging procedure. In this small series, it was associated with frequent complications including arthrofibrosis, and functional outcomes including postoperative ROM were lower than reported for primary TAR. However, pain and function did improve. Further studies are necessary to address long-term clinical and radiographic outcomes in this patient cohort. LEVEL OF EVIDENCE: Level IV, therapeutic study.
[Mh] Termos MeSH primário: Artrodese/métodos
Artroplastia de Substituição do Tornozelo/métodos
Prótese Articular
Desenho de Prótese
Reoperação/métodos
[Mh] Termos MeSH secundário: Adulto
Idoso
Articulação do Tornozelo/diagnóstico por imagem
Articulação do Tornozelo/cirurgia
Artralgia/etiologia
Artrodese/efeitos adversos
Artroplastia de Substituição do Tornozelo/efeitos adversos
Interface Osso-Implante/cirurgia
Feminino
Seres Humanos
Masculino
Meia-Idade
Medição da Dor
Complicações Pós-Operatórias/etiologia
Falha de Prótese
Radiografia
Amplitude de Movimento Articular
Reoperação/efeitos adversos
Estudos Retrospectivos
Resultado do Tratamento
Suporte de Carga
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170421
[St] Status:MEDLINE
[do] DOI:10.1007/s11999-017-5343-4


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[PMID]:28373978
[Au] Autor:Chen HH; Lai WY; Chee TJ; Chan YH; Feng SW
[Ad] Endereço:School of Biomedical Engineering, College of Biomedical Engineering, Taipei Medical University, 250 Wu-Hsing Street, Taipei, Taiwan.
[Ti] Título:Monitoring the Changes of Material Properties at Bone-Implant Interface during the Healing Process In Vivo: A Viscoelastic Investigation.
[So] Source:Biomed Res Int;2017:1945607, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to monitor the changes of viscoelastic properties at bone-implant interface via resonance frequency analysis (RFA) and the Periotest device during the healing process in an experimental rabbit model. Twenty-four dental implants were inserted into the femoral condyles of rabbits. The animals were sacrificed immediately after implant installation or on day 14, 28, or 56 after surgery. Viscoelastic properties at bone-implant interface were evaluated by measuring the implant stability quotient (ISQ) using RFA and by measuring the Periotest values (PTVs) using the Periotest device. The bone/implant specimens were evaluated histopathologically and histomorphometrically to determine the degree of osseointegration (BIC%). The BIC% values at different time points were then compared with the corresponding ISQ values and PTVs. The mean ISQ value increased gradually and reached 81 ± 1.7 on day 56, whereas the mean PTV decreased over time, finally reaching -0.7 ± 0.5 on day 56. Significant correlations were found between ISQ and BIC% ( = 0.701, < 0.001), PTV and BIC% ( = -0.637, < 0.05), and ISQ and PTV ( = -0.68, < 0.05). These results show that there is a positive correlation between implant stability parameters and peri-implant-bone healing, indicating that the RFA and Periotest are useful for measuring changes of viscoelastic properties at bone-implant interface and are reliable for indirectly predicting the degree of osseointegration.
[Mh] Termos MeSH primário: Interface Osso-Implante
Implantes Dentários
Mandíbula/cirurgia
[Mh] Termos MeSH secundário: Animais
Planejamento de Prótese Dentária
Seres Humanos
Mandíbula/patologia
Osseointegração/efeitos dos fármacos
Coelhos
Propriedades de Superfície
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Implants)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1155/2017/1945607


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[PMID]:28303535
[Au] Autor:Boot W; Gawlitta D; Nikkels PGJ; Pouran B; van Rijen MHP; Dhert WJA; Vogely HC
[Ad] Endereço:Department of Orthopaedics, University Medical Center Utrecht, Utrecht, The Netherlands. w.boot@umcutrecht.nl.
[Ti] Título:Hyaluronic Acid-Based Hydrogel Coating Does Not Affect Bone Apposition at the Implant Surface in a Rabbit Model.
[So] Source:Clin Orthop Relat Res;475(7):1911-1919, 2017 Jul.
[Is] ISSN:1528-1132
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Uncemented orthopaedic implants rely on the bone-implant interface to provide stability, therefore it is essential that a coating does not interfere with the bone-forming processes occurring at the implant interface. In addition, local application of high concentrations of antibiotics for prophylaxis or treatment of infection may be toxic for osteoblasts and could impair bone growth. QUESTIONS/PURPOSES: In this animal study, we investigated the effect of a commercially available hydrogel, either unloaded or loaded with 2% vancomycin. We asked, does unloaded hydrogel or hydrogel with vancomycin (1) interfere with bone apposition and timing of bone deposition near the implant surface; and (2) induce a local or systemic inflammatory reaction as determined by inflammation around the implant and hematologic parameters. METHODS: In 18 New Zealand White rabbits, an uncoated titanium rod (n = 6), a rod coated with unloaded hydrogel (n = 6), or a rod coated with 2% vancomycin-loaded hydrogel (n = 6) was implanted in the intramedullary canal of the left tibia. After 28 days, the bone volume fraction near the implant was measured with microCT analysis, inflammation was semiquantitatively scored on histologic sections, and timing of bone apposition was followed by semiquantitative scoring of fluorochrome incorporation on histologic sections. Two observers, blinded to the treatment, scored the sections and reconciled their scores if there was a disagreement. The hematologic inflammatory reaction was analyzed by measuring total and differential leukocyte counts and erythrocyte sedimentation rates in blood. With group sizes of six animals per group, we had 79% power to detect a difference of 25% in histologic scoring for infection and inflammation. RESULTS: No differences were found in the amount of bone apposition near the implant in the No Gel group (48.65% ± 14.95%) compared with the Gel group (59.97% ± 5.02%; mean difference [MD], 11.32%; 95% CI, -3.89% to 26.53%; p = 0.16) or for the Van2 group (56.12% ± 10.06%; MD, 7.46; 95% CI, -7.75 to 22.67; p = 0.40), with the numbers available. In addition, the scores for timing of bone apposition did not differ between the No Gel group (0.50 ± 0.55) compared with the Gel group (0.33 ± 0.52; MD, -0.17; 95% CI, -0.86 to 0.53; p = 0.78) or the Van2 group (0.83 ± 0.41; MD, 0.33; 95% CI, -0.36 to 1.03; p = 0.42). Furthermore, we detected no differences in the histopathology scores for inflammation in the No Gel group (2.33 ± 1.67) compared with the Gel group (3.17 ± 1.59; MD, 0.83; 95% CI, -0.59 to 2.26; p = 0.31) or to the Van2 group (2.5 ± 1.24; MD, 0.17; 95% CI, -1.26 to 1.59; p = 0.95). Moreover, no differences in total leukocyte count, erythrocyte sedimentation rate, and neutrophil, monocyte, eosinophil, basophil, and lymphocyte counts were present between the No Gel or Van2 groups compared with the Gel control group, with the numbers available. CONCLUSION: The hydrogel coated on titanium implants, unloaded or loaded with 2% vancomycin, had no effect on the volume or timing of bone apposition near the implant, and did not induce an inflammatory reaction in vivo, with the numbers available. CLINICAL RELEVANCE: Antibiotic-loaded hydrogel may prove to be a valuable option to protect orthopaedic implants from bacterial colonization. Future clinical safety studies will need to provide more evidence that this product does not impair bone formation near the implant and prove the safety of this product.
[Mh] Termos MeSH primário: Interface Osso-Implante/patologia
Ácido Hialurônico/farmacologia
Hidrogel de Polietilenoglicol-Dimetacrilato/farmacologia
Próteses e Implantes
Vancomicina/administração & dosagem
Vancomicina/farmacologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais
Coelhos
Tíbia/cirurgia
Titânio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
25852-47-5 (Hydrogel, Polyethylene Glycol Dimethacrylate); 6Q205EH1VU (Vancomycin); 9004-61-9 (Hyaluronic Acid); D1JT611TNE (Titanium)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.1007/s11999-017-5310-0


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[PMID]:28291851
[Au] Autor:Gil LF; Sarendranath A; Neiva R; Marão HF; Tovar N; Bonfante EA; Janal MN; Castellano A; Coelho PG
[Ti] Título:Bone Healing Around Dental Implants: Simplified vs Conventional Drilling Protocols at Speed of 400 rpm.
[So] Source:Int J Oral Maxillofac Implants;32(2):329-336, 2017 Mar/Apr.
[Is] ISSN:1942-4434
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study evaluated whether simplified drilling protocols would provide comparable histologic and histomorphometric results to conventional drilling protocols at a low rotational speed. MATERIALS AND METHODS: A total of 48 alumina-blasted and acid-etched Ti-6Al-4V implants with two diameters (3.75 and 4.2 mm, n = 24 per group) were bilaterally placed in the tibiae of 12 dogs, under a low-speed protocol (400 rpm). Within the same diameter group, half of the implants were inserted after a simplified drilling procedure (pilot drill + final diameter drill), and the other half were placed using the conventional drilling procedure. After 3 and 5 weeks, the animals were euthanized, and the retrieved bone-implant samples were subjected to nondecalcified histologic sectioning. Histomorphology, bone-to-implant contact (BIC), and bone area fraction occupancy (BAFO) analysis were performed. RESULTS: Histology showed that new bone was formed around implants, and inflammation or bone resorption was not evident for both groups. Histomorphometrically, when all independent variables were collapsed over drilling technique, no differences were detected for BIC and BAFO; when drilling technique was analyzed as a function of time, the conventional groups reached statistically higher BIC and BAFO at 3 weeks, but comparable values between techniques were observed at 5 weeks; 4.2-mm implants obtained statistically higher BAFO relative to 3.75-mm implants. CONCLUSION: Based on the present methodology, the conventional technique improved bone formation at 3 weeks, and narrower implants were associated with less bone formation.
[Mh] Termos MeSH primário: Interface Osso-Implante/patologia
Implantação Dentária Endo-Óssea/métodos
Implantes Dentários
Osteogênese/fisiologia
Osteotomia/métodos
Cicatrização/fisiologia
[Mh] Termos MeSH secundário: Óxido de Alumínio
Análise de Variância
Animais
Modelos Animais de Doenças
Cães
Masculino
Osseointegração/fisiologia
Propriedades de Superfície
Tíbia/cirurgia
Titânio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dental Implants); D1JT611TNE (Titanium); LMI26O6933 (Aluminum Oxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.11607/jomi.4802


  9 / 237 MEDLINE  
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Mesquita, Marcelo Ferraz
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[PMID]:28291848
[Au] Autor:Cardoso MV; Chaudhari A; Yoshihara K; Mesquita MF; Yoshida Y; Van Meerbeek B; Vandamme K; Duyck J
[Ti] Título:Phosphorylated Pullulan Coating Enhances Titanium Implant Osseointegration in a Pig Model.
[So] Source:Int J Oral Maxillofac Implants;32(2):282-290, 2017 Mar/Apr.
[Is] ISSN:1942-4434
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the effect of coating a titanium implant surface with a phosphorylated exopolysaccharide, pullulan, on the peri-implant bone formation and implant osseointegration. MATERIALS AND METHODS: Implants were placed in the skull bone of 12 domestic pigs and healed for 1 or 3 months. Osseointegration of (un)coated implants was evaluated by quantitative histology (peri-implant bone fraction [BF] and bone-to-implant-contact [BIC]). The Wilcoxon-Mann-Whitney test with α = .05 was used to statistically compare BF and BIC of the coated and uncoated implants. RESULTS: Significantly more BF was observed surrounding pullulan-coated implants compared with uncoated implants (P < .05) and for both healing periods (P < .05). BIC was positively affected by the exopolysaccharide coating, with significantly more BIC after the 3-month healing period compared with the uncoated implant (P < .05). Furthermore, BIC remained stable over time for the coated implants, while it significantly decreased for the uncoated ones (P < .05). CONCLUSION: These findings reveal the capacity of functionalizing the titanium implant surface with phosphorylated pullulan to improve the mineralization of the implant-bone interface.
[Mh] Termos MeSH primário: Materiais Revestidos Biocompatíveis/farmacologia
Implantes Dentários
Materiais Dentários/farmacologia
Glucanos/farmacologia
Osseointegração/efeitos dos fármacos
Titânio/química
[Mh] Termos MeSH secundário: Animais
Interface Osso-Implante/fisiologia
Materiais Dentários/química
Modelos Animais de Doenças
Implantes Experimentais
Osteogênese/efeitos dos fármacos
Crânio/cirurgia
Propriedades de Superfície
Sus scrofa
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 0 (Dental Implants); 0 (Dental Materials); 0 (Glucans); 8ZQ0AYU1TT (pullulan); D1JT611TNE (Titanium)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE
[do] DOI:10.11607/jomi.5074


  10 / 237 MEDLINE  
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[PMID]:28238010
[Au] Autor:Okada Y; Abe N; Hisamori N; Kaneeda T; Moriyama S; Ohmori H; Mizutani M; Yanai H; Nakashima Y; Yokoyama Y; Ozaki T
[Ad] Endereço:Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan.
[Ti] Título:Verification of Implant Surface Modification by a Novel Processing Method.
[So] Source:Acta Med Okayama;71(1):49-57, 2017 Feb.
[Is] ISSN:0386-300X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Metals have been used clinically as biomaterials, especially in the orthopaedic and dental fields. Metals used as implants wear at contact surfaces, producing metal particles and metal ions that may be harmful. Newly developed metal implants and methods of implant surface modification are currently under scrutiny. We evaluated the use of electrolytic in-process dressing (ELID) as a surface finishing method for metal implants. Metal implants processed using the ELID method (ELID group) or not processed (Non-ELID group) were inserted surgically into rabbit femurs. The rabbits were sacrificed postoperatively over a 24-week period. We assessed the concentrations of the cytokines, interleukin (IL)-1ß, IL-6, and tumor necrosis factor-α, the resistance to implant pull-out, and histopathology at the implant site. There was no significant difference between the groups regarding the cytokine concentrations or implant pull-out resistance. Many particles indicating wear around the implant were noted in the Non-ELID group (n=10) but not the ELID group (n=13), while a fibrous membrane adhering to the every implant was noted in the ELID group. The formation of a fibrous membrane rather than metal particles in the ELID group may indicate improved biocompatibility, and it suggests that ELID may prevent corrosion in the areas of contact.
[Mh] Termos MeSH primário: Interface Osso-Implante
Materiais Revestidos Biocompatíveis/farmacologia
Procedimentos Ortopédicos/instrumentação
Próteses e Implantes/efeitos adversos
Titânio/farmacologia
[Mh] Termos MeSH secundário: Animais
Fêmur/cirurgia
Seres Humanos
Interleucina-6/análise
Fenômenos Mecânicos
Microscopia Confocal
Modelos Animais
Coelhos
Tomografia Computadorizada por Raios X
Fator de Necrose Tumoral alfa/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Coated Materials, Biocompatible); 0 (Interleukin-6); 0 (Tumor Necrosis Factor-alpha); D1JT611TNE (Titanium)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170227
[St] Status:MEDLINE
[do] DOI:10.18926/AMO/54825



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