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[PMID]:29437071
[Au] Autor:Puri A; Ranganathan P; Gulia A; Crasto S; Hawaldar R; Badwe RA
[Ad] Endereço:Tata Memorial Centre, HBNI, Dr E. Borges Road, Parel, Mumbai 400 012, India.
[Ti] Título:Does a less intensive surveillance protocol affect the survival of patients after treatment of a sarcoma of the limb? updated results of the randomized TOSS study.
[So] Source:Bone Joint J;100-B(2):262-268, 2018 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: A single-centre prospective randomized trial was conducted to investigate whether a less intensive follow-up protocol would not be inferior to a conventional follow-up protocol, in terms of overall survival, in patients who have undergone surgery for sarcoma of the limb. Initial short-term results were published in 2014. PATIENTS AND METHODS: The primary objective was to show non-inferiority of a chest radiograph (CXR) group compared with a CT scan group, and of a less frequent (six-monthly) group than a more frequent (three-monthly) group, in two-by-two comparison. The primary outcome was overall survival and the secondary outcome was a recurrence-free survival. Five-year survival was compared between the CXR and CT scan groups and between the three-monthly and six-monthly groups. Of 500 patients who were enrolled, 476 were available for follow-up. Survival analyses were performed on a per-protocol basis (n = 412). RESULTS: The updated results recorded 12 (2.4%) local recurrences, 182 (36.8%) metastases, and 56 (11.3%) combined (local + metastases) recurrence at a median follow-up of 81 months (60 to 118). Of 68 local recurrences, 60 (88%) were identified by the patients themselves. The six-monthly regime (overall survival (OS) 54%, recurrence-free survival (RFS) 46%) did not lead to a worse survival and was not inferior to the three-monthly regime (OS 55%, RFS 47%) in terms of detecting recurrence. Although CT scans (OS 53%, RFS 54%) detected pulmonary metastasis earlier, it did not lead to a better survival compared with CXR (OS 56%, RFS 59%). CONCLUSION: The overall survival of patients who are treated for a sarcoma of the limb is not inferior to those followed up with a less intensive regimen than a more intensive protocol, in terms of frequency of visits and mode of imaging. CXR at six-monthly intervals and patient education about examination of the site of the surgery will detect most recurrences without deleterious effects on the eventual outcome. Cite this article: 2018;100-B:262-8.
[Mh] Termos MeSH primário: Neoplasias Ósseas/mortalidade
Neoplasias Ósseas/cirurgia
Vigilância da População
Sarcoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Ossos do Braço/patologia
Ossos do Braço/cirurgia
Neoplasias Ósseas/patologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Índia
Ossos da Perna/patologia
Ossos da Perna/cirurgia
Masculino
Meia-Idade
Recidiva Local de Neoplasia/patologia
Estudos Prospectivos
Sarcoma/mortalidade
Taxa de Sobrevida
[Pt] Tipo de publicação:EQUIVALENCE TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B2.BJJ-2017-0789.R1


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[PMID]:29437070
[Au] Autor:Kim W; Lee JS; Chung HW
[Ad] Endereço:Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.
[Ti] Título:Outcomes after extensive manual curettage and limited burring for atypical cartilaginous tumour of long bone.
[So] Source:Bone Joint J;100-B(2):256-261, 2018 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Adjuvant treatment after intralesional curettage for atypical cartilaginous tumours (ACTs) of long bones is widely accepted for extending surgical margins. However, evaluating the isolated effect of adjuvant treatment is difficult, and it is unclear whether not using such adjuvants provides poor oncological outcomes. Hence, we analyzed whether intralesional curettage without cryosurgery or chemical adjuvants provides poor oncological outcomes in patients with an ACT. PATIENTS AND METHODS: A total of 24 patients (nine men, 15 women) (mean age 45 years; 18 to 62) were treated for ACTs of long bones and followed up for a median of 66 months (interquartile range 50 to 84). All patients were treated with extensive manual curettage and limited burring. Bone cement and grafts were used to fill bone defects in 16 and eight patients, respectively. No chemical adjuvants or cryosurgery were used. RESULTS: No local recurrence was detectable on plain radiographs and MRI or CT images. At the last follow-up, there were no distant metastases or disease-specific deaths. No procedure-related complications or postoperative fractures developed. CONCLUSION: Intralesional curettage without cryosurgery or chemical adjuvants may provide excellent oncological outcomes for patients with ACTs of long bones, without the risk of complications related to adjuvant use. Our investigation suggests thorough curettage alone is a reasonable treatment option for ACT. However, we acknowledge the limited size of our investigation warrants a multicentre collaborative study to confirm our findings. Cite this article: 2018;100-B:256-61.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Condrossarcoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ossos do Braço/diagnóstico por imagem
Ossos do Braço/patologia
Ossos do Braço/cirurgia
Biópsia
Cimentos para Ossos
Neoplasias Ósseas/diagnóstico por imagem
Neoplasias Ósseas/patologia
Transplante Ósseo
Condrossarcoma/diagnóstico por imagem
Condrossarcoma/patologia
Curetagem
Feminino
Seres Humanos
Ossos da Perna/diagnóstico por imagem
Ossos da Perna/patologia
Ossos da Perna/cirurgia
Masculino
Meia-Idade
Estudos Prospectivos
Instrumentos Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Cements)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B2.BJJ-2017-0707.R1


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[PMID]:28860406
[Au] Autor:Emori M; Kaya M; Irifune H; Takahashi N; Shimizu J; Mizushima E; Murahashi Y; Yamashita T
[Ad] Endereço:Sapporo Medical University School of Medicine, West 16, South 1, Chuo- ku, Sapporo, Hokkaido, 060-8543, Japan.
[Ti] Título:Vascularised fibular grafts for reconstruction of extremity bone defects after resection of bone and soft-tissue tumours : a single institutional study of 49 patients.
[So] Source:Bone Joint J;99-B(9):1237-1243, 2017 Sep.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The aims of this study were to analyse the long-term outcome of vascularised fibular graft (VFG) reconstruction after tumour resection and to evaluate the usefulness of the method. PATIENTS AND METHODS: We retrospectively reviewed 49 patients who had undergone resection of a sarcoma and reconstruction using a VFG between 1988 and 2015. Their mean follow-up was 98 months (5 to 317). Reconstruction was with an osteochondral graft (n = 13), intercalary graft (n = 12), inlay graft (n = 4), or resection arthrodesis (n = 20). We analysed the oncological and functional outcome, and the rate of bony union and complications. RESULTS: Five- and ten-year overall survival rates were 89% and 86%, respectively. Local recurrence occurred in two patients. Eight patients developed pulmonary metastases. Bone union was achieved in 44 patients (90%). Fracture occurred in six patients (12%), infection in three (6%), and nonunion in five (10%). The mean Musculoskeletal Tumor Society (MSTS) scores were as follows: osteochondral graft 70%; intercalary graft 73%; inlay graft 89%; and resection arthrodesis 83%. CONCLUSION: Although associated with a relatively high rate of complications, each reconstruction method is useful, with a high rate of successful limb salvage and a good long-term functional outcome. Cite this article: 2017;99-B:1237-43.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Fíbula/transplante
Ossos da Perna/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Sarcoma/cirurgia
Neoplasias de Tecidos Moles/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Neoplasias Ósseas/patologia
Criança
Feminino
Fíbula/irrigação sanguínea
Seres Humanos
Salvamento de Membro
Masculino
Meia-Idade
Recidiva Local de Neoplasia
Estadiamento de Neoplasias
Complicações Pós-Operatórias
Estudos Retrospectivos
Sarcoma/patologia
Neoplasias de Tecidos Moles/patologia
Taxa de Sobrevida
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.99B9.BJJ-2017-0219.R1


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[PMID]:28233039
[Au] Autor:Mayr G; De Pietri VL; Paul Scofield R
[Ad] Endereço:Ornithological Section, Senckenberg Research Institute and Natural History Museum Frankfurt, Senckenberganlage 25, 60325, Frankfurt am Main, Germany. Gerald.Mayr@senckenberg.de.
[Ti] Título:A new fossil from the mid-Paleocene of New Zealand reveals an unexpected diversity of world's oldest penguins.
[So] Source:Naturwissenschaften;104(3-4):9, 2017 Apr.
[Is] ISSN:1432-1904
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:We describe leg bones of a giant penguin from the mid-Paleocene Waipara Greensand of New Zealand. The specimens were found at the type locality of Waimanu manneringi and together with this species they constitute the oldest penguin fossils known to date. Tarsometatarsus dimensions indicate a species that reached the size of Anthropornis nordenskjoeldi, one of the largest known penguin species. Stem group penguins therefore attained a giant size very early in their evolution, with this gigantism existing for more than 30 million years. The new fossils are from a species that is phylogenetically more derived than Waimanu, and the unexpected coexistence of Waimanu with more derived stem group Sphenisciformes documents a previously unknown diversity amongst the world's oldest penguins. The characteristic tarsometatarsus shape of penguins evolved early on, and the significant morphological disparity between Waimanu and the new fossil conflicts with recent Paleocene divergence estimates for penguins, suggesting an older, Late Cretaceous, origin.
[Mh] Termos MeSH primário: Biodiversidade
Fósseis
Filogenia
Spheniscidae/anatomia & histologia
Spheniscidae/classificação
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal
Ossos da Perna/anatomia & histologia
Nova Zelândia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170916
[Lr] Data última revisão:
170916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1007/s00114-017-1441-0


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[PMID]:27935105
[Au] Autor:Davies BM; Snelling SJB; Quek L; Hakimi O; Ye H; Carr A; Price AJ
[Ad] Endereço:Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, England, United Kingdom.
[Ti] Título:Identifying the optimum source of mesenchymal stem cells for use in knee surgery.
[So] Source:J Orthop Res;35(9):1868-1875, 2017 Sep.
[Is] ISSN:1554-527X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Single sitting procedures where the mononuclear cell fraction is extracted from bone marrow and implanted directly into cartilage and bone defects are becoming more popular as novel treatments for cartilage defects which have, until now had few treatment options. This is on the basis that the mesenchymal stem cells (MSCs) contained within will repair the damaged tissue. This study sought to determine if the femur and tibia could provide equivalent amounts of mesenchymal stem cells, with equivalent viability and proliferative capacity, to that obtained from the gold standard of the pelvis in order to potentially reduce the morbidity associated with these procedures. Bone marrow was extracted from the pelvis, femur, and tibia of human subjects. The mononuclear cell fraction was extracted and cultured in the laboratory. Mesenchymal stem cell populations were assessed using a colony forming unit count. Viability was assessed using a PrestoBlue viability assay. Population doubling number was calculated between the end of passage 0 and passage three to determine the proliferative abilities of the different populations. Finally, the cell surface phenotype of the cells was determined by flow cytometry. The results showed that the pelvis was superior to the femur and tibia in terms of the number of stem cells isolated. There was no statistically significant difference in the phenotype of the cells isolated from different locations. This work shows that when undertaking single sitting procedures, the pelvis remains the optimum source for obtaining MSCs, despite the morbidity associated with bone marrow collection from the pelvis. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1868-1875, 2017.
[Mh] Termos MeSH primário: Células da Medula Óssea
Articulação do Joelho/cirurgia
Ossos da Perna/citologia
Transplante de Células-Tronco Mesenquimais/métodos
Ossos Pélvicos/citologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161210
[St] Status:MEDLINE
[do] DOI:10.1002/jor.23501


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[PMID]:27855981
[Au] Autor:Marchi D; Walker CS; Wei P; Holliday TW; Churchill SE; Berger LR; DeSilva JM
[Ad] Endereço:Department of Biology, University of Pisa, Via Derna 1, Pisa 56126, Italy; Evolutionary Studies Institute and Centre for Excellence in PalaeoSciences, University of the Witwatersrand, Private Bag 3, Wits 2050, South Africa. Electronic address: damiano.marchi@unipi.it.
[Ti] Título:The thigh and leg of Homo naledi.
[So] Source:J Hum Evol;104:174-204, 2017 Mar.
[Is] ISSN:1095-8606
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This paper describes the 108 femoral, patellar, tibial, and fibular elements of a new species of Homo (Homo naledi) discovered in the Dinaledi chamber of the Rising Star cave system in South Africa. Homo naledi possesses a mosaic of primitive, derived, and unique traits functionally indicative of a bipedal hominin adapted for long distance walking and possibly running. Traits shared with australopiths include an anteroposteriorly compressed femoral neck, a mediolaterally compressed tibia, and a relatively circular fibular neck. Traits shared with Homo include a well-marked linea aspera, anteroposteriorly thick patellae, relatively long tibiae, and gracile fibulae with laterally oriented lateral malleoli. Unique features include the presence of two pillars on the superior aspect of the femoral neck and a tubercular distal insertion of the pes anserinus on the tibia. The mosaic morphology of the H. naledi thigh and leg appears most consistent with a species intermediate between Australopithecus spp. and Homo erectus and, accordingly, may offer insight into the nature of the earliest members of genus Homo. These fossils also expand the morphological diversity of the Homo lower limb, perhaps indicative of locomotor diversity in our genus.
[Mh] Termos MeSH primário: Fósseis/anatomia & histologia
Hominidae/anatomia & histologia
Ossos da Perna/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


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[PMID]:27696364
[Au] Autor:Boeyer ME; Ousley SD
[Ad] Endereço:Department of Pathology and Anatomical Sciences, University of Missouri, Columbia, MO, 65212.
[Ti] Título:Skeletal assessment and secular changes in knee development: a radiographic approach.
[So] Source:Am J Phys Anthropol;162(2):229-240, 2017 Feb.
[Is] ISSN:1096-8644
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The purpose of this study is to conduct an analysis of ossification patterns in the distal femoral, proximal tibial, and proximal fibular epiphyses, and the patella. The results generated from this analysis will be compared with previous standards published by Elgenmark () and Garn et al. () to determine if clinical and skeletal age assessment standards should be updated for contemporary Americans. MATERIALS AND METHODS: Using the Pediatric Radiology Interactive Atlas (Patricia), a total of 1,317 epiphyses were scored for presence or absence from radiographs of 1,056 white individuals born in or after 1990. Statistical modeling of epiphyseal appearance was conducted for all major percentiles, including the 5th and 95th percentiles through logistic regression. RESULTS: Compared with Elgenmark () and Garn et al. (), our data suggest that the distal femoral and proximal tibial epiphyses show overall earlier ossification, while the proximal fibular epiphysis shows later ossification. When examining the pooled sex 50th percentile for our data, we found that ossification timing differences are 1.2 weeks earlier in the distal femoral epiphysis, 2.1 weeks earlier in the proximal tibial epiphysis, and 1.4 years later in the proximal fibular epiphysis. DISCUSSION: The epiphyses that appear early in life, for example the distal femoral epiphysis, require gestational age information to accurately estimate appearance times. There are considerable differences between the ossification timing patterns presented in this study and those of previous standards, which did not include gestational ages. Several factors may explain the observed differences in the epiphyses of the knee including: the availability of gestational age information, the analysis of longitudinal versus cross-sectional data, differences in socioeconomic status and prenatal care, and secular change. KEYWORDS age estimation, growth standards, ossification, skeletal maturation, subadult/juvenile growth.
[Mh] Termos MeSH primário: Epífises/crescimento & desenvolvimento
Articulação do Joelho/crescimento & desenvolvimento
Ossos da Perna/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Determinação da Idade pelo Esqueleto
Antropologia Física
Criança
Pré-Escolar
Epífises/anatomia & histologia
Epífises/diagnóstico por imagem
Feminino
Seres Humanos
Articulação do Joelho/anatomia & histologia
Articulação do Joelho/diagnóstico por imagem
Ossos da Perna/anatomia & histologia
Ossos da Perna/diagnóstico por imagem
Masculino
Radiografia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1002/ajpa.23110


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[PMID]:27733199
[Au] Autor:Dell'Isola A; Allan R; Smith SL; Marreiros SS; Steultjens M
[Ad] Endereço:Institute of Applied Health Research/School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, Scotland, UK. andrea.dellIsola@gcu.ac.uk.
[Ti] Título:Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature.
[So] Source:BMC Musculoskelet Disord;17(1):425, 2016 Oct 12.
[Is] ISSN:1471-2474
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Knee Osteoarthritis (KOA) is a heterogeneous pathology characterized by a complex and multifactorial nature. It has been hypothesised that these differences are due to the existence of underlying phenotypes representing different mechanisms of the disease. METHODS: The aim of this study is to identify the current evidence for the existence of groups of variables which point towards the existence of distinct clinical phenotypes in the KOA population. A systematic literature search in PubMed was conducted. Only original articles were selected if they aimed to identify phenotypes of patients aged 18 years or older with KOA. The methodological quality of the studies was independently assessed by two reviewers and qualitative synthesis of the evidence was performed. Strong evidence for existence of specific phenotypes was considered present if the phenotype was supported by at least two high-quality studies. RESULTS: A total of 24 studies were included. Through qualitative synthesis of evidence, six main sets of variables proposing the existence of six phenotypes were identified: 1) chronic pain in which central mechanisms (e.g. central sensitisation) are prominent; 2) inflammatory (high levels of inflammatory biomarkers); 3) metabolic syndrome (high prevalence of obesity, diabetes and other metabolic disturbances); 4) Bone and cartilage metabolism (alteration in local tissue metabolism); 5) mechanical overload characterised primarily by varus malalignment and medial compartment disease; and 6) minimal joint disease characterised as minor clinical symptoms with slow progression over time. CONCLUSIONS: This study identified six distinct groups of variables which should be explored in attempts to better define clinical phenotypes in the KOA population.
[Mh] Termos MeSH primário: Osteoartrite do Joelho
[Mh] Termos MeSH secundário: Cartilagem Articular/metabolismo
Dor Crônica
Progressão da Doença
Seres Humanos
Ossos da Perna/metabolismo
Síndrome Metabólica
Osteoartrite do Joelho/diagnóstico
Osteoartrite do Joelho/metabolismo
Osteoartrite do Joelho/patologia
Osteoartrite do Joelho/fisiopatologia
Pesquisa Qualitativa
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161014
[St] Status:MEDLINE


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[PMID]:27511611
[Au] Autor:Janssen SJ; Paulino Pereira NR; Raskin KA; Ferrone ML; Hornicek FJ; van Dijk CN; Lozano-Calderón SA; Schwab JH
[Ad] Endereço:Department of Orthopaedic Surgery, Orthopaedic Oncology Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. steinjanssen@gmail.com.
[Ti] Título:A comparison of questionnaires for assessing physical function in patients with lower extremity bone metastases.
[So] Source:J Surg Oncol;114(6):691-696, 2016 Nov.
[Is] ISSN:1096-9098
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To assess, (i) the degree to which the: PROMIS Physical Function Cancer, PROMIS Neuro-QoL Mobility, Toronto Extremity Salvage Score (TESS), Lower Extremity Function Score (LEFS), and Musculoskeletal Tumor Society score (MSTS), measure physical function; (ii) differences in coverage and reliability; and (iii) difference in completion time. METHODS: One hundred of 115 (87%) patients with lower extremity metastases participated in this prospective study. We used exploratory factor analysis-correlating questionnaires with an underlying trait-to assess if questionnaires measure the same. Coverage was assessed by floor and ceiling effect and reliability by the standard error of measurement (SEM). Completion time was compared using the Friedman test. RESULTS: All questionnaires measured the same concept; demonstrated by high correlations (>0.7). Floor effect was absent, while ceiling effect was present in all, but highest for the PROMIS Neuro-QoL Mobility (7%). The SEM was below the threshold-indicating reliability-over a wide range of ability levels for the PROMIS-Physical Function, TESS, and LEFS. Completion time differed between questionnaires (P < 0.001) and was shortest for the PROMIS questionnaires. CONCLUSIONS: The PROMIS Physical Function is the most useful questionnaire. This is due to its reliability over a wide range of ability levels, validity, brevity, and good coverage. J. Surg. Oncol. 2016;114:691-696. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Neoplasias Ósseas/fisiopatologia
Neoplasias Ósseas/secundário
Indicadores Básicos de Saúde
Ossos da Perna
Ossos Pélvicos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Análise Fatorial
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Reprodutibilidade dos Testes
Adulto Jovem
[Pt] Tipo de publicação:CLINICAL TRIAL; COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE
[do] DOI:10.1002/jso.24400


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[PMID]:27362757
[Au] Autor:Schmitz A; Piovesan D
[Ti] Título:Development of an Open-Source, Discrete Element Knee Model.
[So] Source:IEEE Trans Biomed Eng;63(10):2056-67, 2016 Oct.
[Is] ISSN:1558-2531
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Biomechanical modeling is an important tool in that it can provide estimates of forces that cannot easily be measured (e.g., soft tissue loads). The goal of this study was to develop a discrete element model of the knee that is open source to allow for utilization of modeling by a wider audience of researchers. METHODS: A six degree-of-freedom tibiofemoral and one degree-of-freedom patellofemoral joint were created in OpenSim. Eighteen ligament bundles and tibiofemoral contact were included in the model. RESULTS: During a passive flexion movement, maximum deviation of the model from the literature occurred at the most flexed angle with deviations of 2° adduction, 7° internal rotation, 1-mm posterior translation, 12-mm inferior translation, and 4-mm lateral translation. Similarly, the overall elongation of the ligaments agreed with literature values with strains of less than 13%. CONCLUSION: These results provide validation of the physiological relevance of the model. SIGNIFICANCE: This model is one of the few open source, discrete element knee models to date, and has many potential applications, one being for use in an open-source cosimulation framework.
[Mh] Termos MeSH primário: Fenômenos Biomecânicos/fisiologia
Articulação do Joelho
Modelos Biológicos
Amplitude de Movimento Articular/fisiologia
[Mh] Termos MeSH secundário: Biologia Computacional
Seres Humanos
Articulação do Joelho/anatomia & histologia
Articulação do Joelho/diagnóstico por imagem
Articulação do Joelho/fisiologia
Ossos da Perna/anatomia & histologia
Ossos da Perna/diagnóstico por imagem
Ossos da Perna/fisiologia
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160701
[St] Status:MEDLINE
[do] DOI:10.1109/TBME.2016.2585926



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