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Pesquisa : A02.835.232.087.090 [Categoria DeCS]
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[PMID]:29437071
[Au] Autor:Puri A; Ranganathan P; Gulia A; Crasto S; Hawaldar R; Badwe RA
[Ad] Endereço:Tata Memorial Centre, HBNI, Dr E. Borges Road, Parel, Mumbai 400 012, India.
[Ti] Título:Does a less intensive surveillance protocol affect the survival of patients after treatment of a sarcoma of the limb? updated results of the randomized TOSS study.
[So] Source:Bone Joint J;100-B(2):262-268, 2018 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: A single-centre prospective randomized trial was conducted to investigate whether a less intensive follow-up protocol would not be inferior to a conventional follow-up protocol, in terms of overall survival, in patients who have undergone surgery for sarcoma of the limb. Initial short-term results were published in 2014. PATIENTS AND METHODS: The primary objective was to show non-inferiority of a chest radiograph (CXR) group compared with a CT scan group, and of a less frequent (six-monthly) group than a more frequent (three-monthly) group, in two-by-two comparison. The primary outcome was overall survival and the secondary outcome was a recurrence-free survival. Five-year survival was compared between the CXR and CT scan groups and between the three-monthly and six-monthly groups. Of 500 patients who were enrolled, 476 were available for follow-up. Survival analyses were performed on a per-protocol basis (n = 412). RESULTS: The updated results recorded 12 (2.4%) local recurrences, 182 (36.8%) metastases, and 56 (11.3%) combined (local + metastases) recurrence at a median follow-up of 81 months (60 to 118). Of 68 local recurrences, 60 (88%) were identified by the patients themselves. The six-monthly regime (overall survival (OS) 54%, recurrence-free survival (RFS) 46%) did not lead to a worse survival and was not inferior to the three-monthly regime (OS 55%, RFS 47%) in terms of detecting recurrence. Although CT scans (OS 53%, RFS 54%) detected pulmonary metastasis earlier, it did not lead to a better survival compared with CXR (OS 56%, RFS 59%). CONCLUSION: The overall survival of patients who are treated for a sarcoma of the limb is not inferior to those followed up with a less intensive regimen than a more intensive protocol, in terms of frequency of visits and mode of imaging. CXR at six-monthly intervals and patient education about examination of the site of the surgery will detect most recurrences without deleterious effects on the eventual outcome. Cite this article: 2018;100-B:262-8.
[Mh] Termos MeSH primário: Neoplasias Ósseas/mortalidade
Neoplasias Ósseas/cirurgia
Vigilância da População
Sarcoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Ossos do Braço/patologia
Ossos do Braço/cirurgia
Neoplasias Ósseas/patologia
Criança
Pré-Escolar
Feminino
Seres Humanos
Índia
Ossos da Perna/patologia
Ossos da Perna/cirurgia
Masculino
Meia-Idade
Recidiva Local de Neoplasia/patologia
Estudos Prospectivos
Sarcoma/mortalidade
Taxa de Sobrevida
[Pt] Tipo de publicação:EQUIVALENCE TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B2.BJJ-2017-0789.R1


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[PMID]:29437070
[Au] Autor:Kim W; Lee JS; Chung HW
[Ad] Endereço:Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.
[Ti] Título:Outcomes after extensive manual curettage and limited burring for atypical cartilaginous tumour of long bone.
[So] Source:Bone Joint J;100-B(2):256-261, 2018 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: Adjuvant treatment after intralesional curettage for atypical cartilaginous tumours (ACTs) of long bones is widely accepted for extending surgical margins. However, evaluating the isolated effect of adjuvant treatment is difficult, and it is unclear whether not using such adjuvants provides poor oncological outcomes. Hence, we analyzed whether intralesional curettage without cryosurgery or chemical adjuvants provides poor oncological outcomes in patients with an ACT. PATIENTS AND METHODS: A total of 24 patients (nine men, 15 women) (mean age 45 years; 18 to 62) were treated for ACTs of long bones and followed up for a median of 66 months (interquartile range 50 to 84). All patients were treated with extensive manual curettage and limited burring. Bone cement and grafts were used to fill bone defects in 16 and eight patients, respectively. No chemical adjuvants or cryosurgery were used. RESULTS: No local recurrence was detectable on plain radiographs and MRI or CT images. At the last follow-up, there were no distant metastases or disease-specific deaths. No procedure-related complications or postoperative fractures developed. CONCLUSION: Intralesional curettage without cryosurgery or chemical adjuvants may provide excellent oncological outcomes for patients with ACTs of long bones, without the risk of complications related to adjuvant use. Our investigation suggests thorough curettage alone is a reasonable treatment option for ACT. However, we acknowledge the limited size of our investigation warrants a multicentre collaborative study to confirm our findings. Cite this article: 2018;100-B:256-61.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Condrossarcoma/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Ossos do Braço/diagnóstico por imagem
Ossos do Braço/patologia
Ossos do Braço/cirurgia
Biópsia
Cimentos para Ossos
Neoplasias Ósseas/diagnóstico por imagem
Neoplasias Ósseas/patologia
Transplante Ósseo
Condrossarcoma/diagnóstico por imagem
Condrossarcoma/patologia
Curetagem
Feminino
Seres Humanos
Ossos da Perna/diagnóstico por imagem
Ossos da Perna/patologia
Ossos da Perna/cirurgia
Masculino
Meia-Idade
Estudos Prospectivos
Instrumentos Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bone Cements)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B2.BJJ-2017-0707.R1


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[PMID]:28233101
[Au] Autor:Krap T; Nota K; Wilk LS; van de Goot FRW; Ruijter JM; Duijst W; Oostra RJ
[Ad] Endereço:Department of Anatomy, Embryology and Physiology, Academic Medical Centre, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands. T.Krap@amc.nl.
[Ti] Título:Luminescence of thermally altered human skeletal remains.
[So] Source:Int J Legal Med;131(4):1165-1177, 2017 Jul.
[Is] ISSN:1437-1596
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Literature on luminescent properties of thermally altered human remains is scarce and contradictory. Therefore, the luminescence of heated bone was systemically reinvestigated. A heating experiment was conducted on fresh human bone, in two different media, and cremated human remains were recovered from a modern crematory. Luminescence was excited with light sources within the range of 350 to 560 nm. The excitation light was filtered out by using different long pass filters, and the luminescence was analysed by means of a scoring method. The results show that temperature, duration and surrounding medium determine the observed emission intensity and bandwidth. It is concluded that the luminescent characteristic of bone can be useful for identifying thermally altered human remains in a difficult context as well as yield information on the perimortem and postmortem events.
[Mh] Termos MeSH primário: Ossos do Braço/patologia
Cremação
Luminescência
[Mh] Termos MeSH secundário: Idoso
Restos Mortais
Feminino
Antropologia Forense
Temperatura Alta
Seres Humanos
Luz
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170225
[St] Status:MEDLINE
[do] DOI:10.1007/s00414-017-1546-1


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[PMID]:27839696
[Au] Autor:Feuerriegel EM; Green DJ; Walker CS; Schmid P; Hawks J; Berger LR; Churchill SE
[Ad] Endereço:School of Archaeology and Anthropology, College of Arts and Social Sciences, Australian National University, Canberra, ACT 2601, Australia; Evolutionary Studies Institute and Centre for Excellence in PalaeoSciences, University of the Witwatersrand, Private Bag 3, Wits 2050, South Africa. Electronic
[Ti] Título:The upper limb of Homo naledi.
[So] Source:J Hum Evol;104:155-173, 2017 Mar.
[Is] ISSN:1095-8606
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The evolutionary transition from an ape-like to human-like upper extremity occurred in the context of a behavioral shift from an upper limb predominantly involved in locomotion to one adapted for manipulation. Selection for overarm throwing and endurance running is thought to have further shaped modern human shoulder girdle morphology and its position about the thorax. Homo naledi (Dinaledi Chamber, Rising Star Cave, Cradle of Humankind, South Africa) combines an australopith-like cranial capacity with dental characteristics akin to early Homo. Although the hand, foot, and lower limb display many derived morphologies, the upper limb retains many primitive traits. Here, we describe the H. naledi upper extremity (excluding the hand) in detail and in a comparative context to evaluate the diversity of clavicular, scapular, humeral, radial, and ulnar morphology among early hominins and later Homo. Homo naledi had a scapula with a markedly cranially-oriented glenoid, a humerus with extremely low torsion, and an australopith-like clavicle. These traits indicate that the H. naledi scapula was situated superiorly and laterally on the thorax. This shoulder girdle configuration is more similar to that of Australopithecus and distinct from that of modern humans, whose scapulae are positioned low and dorsally about the thorax. Although early Homo erectus maintains many primitive clavicular and humeral features, its derived scapular morphology suggests a loss of climbing adaptations. In contrast, the H. naledi upper limb is markedly primitive, retaining morphology conducive to climbing while lacking many of the derived features related to effective throwing or running purported to characterize other members of early Homo.
[Mh] Termos MeSH primário: Ossos do Braço/anatomia & histologia
Fósseis/anatomia & histologia
Hominidae/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Evolução Biológica
África do Sul
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


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[PMID]:27737577
[Au] Autor:Jantz RL; Jantz LM; Devlin JL
[Ad] Endereço:1 Department of Anthropology, University of Tennessee, Knoxville, Tennessee.
[Ti] Título:Secular Changes in the Postcranial Skeleton of American Whites.
[So] Source:Hum Biol;88(1):65-75, 2016 Jan.
[Is] ISSN:1534-6617
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Secular change in height has been extensively investigated, but size and shape of the postcranial skeleton much less so. The availability of large, documented collections of nineteenth- and twentieth-century skeletons makes it possible to examine changes in skeletal structure over the past 150 years. We examined secular changes in long bone lengths and proportions, their allometric relationship to stature, and crosssectional properties of long bone shafts. Bone measurements and stature were organized into 10-year birth cohorts, ranging from 1840 to 1989. Variation among cohorts was tested by one-way ANOVA, and secular trend was examined visually by plotting mean measurements by birth decade. Allometry was examined by regressing log bone lengths onto log stature, using least squares regression. Allometry was also examined using the geometric mean of log bone lengths as the size variable. All bone lengths and stature showed positive secular change. Stature and the distal long bones showed the most pronounced changes. Proportions also changed, as revealed by the brachial and crural indices. Both indices increased, but the brachial index change was the most pronounced. Allometric relationships suggest that brachial index changes result from positive allometry of the radius and negative allometry of the humerus. Similar but less marked allometric relationships were found in the tibia and femur. Long bone shaft properties changed in the following ways: femur midshafts and tibia shafts at the nutrient foramen became more mediolaterally narrowed, and the femur became more mediolaterally thickened at the subtrochanteric level, approaching platymeria. All major long bones became more gracile. These remarkable changes in the postcranial skeleton are a response to the unparalleled changes in the environment in which modern Americans now live. Changes in growth resulting from plentiful and secure nutrition, reduced disease load, and marked reduction in bone loading from reduced activity levels are mainly responsible.
[Mh] Termos MeSH primário: Ossos do Braço/anatomia & histologia
Fósseis/anatomia & histologia
[Mh] Termos MeSH secundário: Análise de Variância
Estatura
Grupo com Ancestrais do Continente Europeu
Feminino
Seres Humanos
Masculino
Estados Unidos/etnologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161015
[St] Status:MEDLINE


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[PMID]:27251047
[Au] Autor:Carneiro C; Curate F; Cunha E
[Ad] Endereço:Garcia de Orta Hospital, EPE, Almada, Portugal. cristianacarneiro@sapo.pt.
[Ti] Título:A method for estimating gestational age of fetal remains based on long bone lengths.
[So] Source:Int J Legal Med;130(5):1333-41, 2016 Sep.
[Is] ISSN:1437-1596
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The estimation of gestational age (GA) in fetal human remains is important in forensic settings, particularly to assess fetal viability, in addition to often being the only biological profile parameter that can be assessed with some accuracy for non-adults. The length of long bone diaphysis is one of the most frequently used methods for fetal age estimation. The main objective of this study was to present a simple and objective method for estimating GA based on the measurements of the diaphysis of the femur, tibia, fibula, humerus, ulna, and radius. Conventional least squares regression equations (classical and inverse calibration approaches) and quick reference tables were generated. A supplementary objective was to compare the performance of the new formulae against previously published models. The sample comprised 257 fetuses (136 females and 121 males) with known GA (between 12 and 40 weeks) and was selected based on clinical and pathological information. All measurements were performed on radiographic images acquired in anonymous clinical autopsy records from spontaneous and therapeutic abortions in two Portuguese hospitals. The proposed technique is straightforward and reproducible. The models for the GA estimation are exceedingly accurate and unbiased. Comparisons between inverse and classical calibration show that both perform exceptionally well, with high accuracy and low bias. Also, the newly developed equations generally outperform earlier methods of GA estimation in forensic contexts. Quick reference tables for each long bone are now available. The obtained models for the estimation of gestational age are of great applicability in forensic contexts.
[Mh] Termos MeSH primário: Determinação da Idade pelo Esqueleto/métodos
Ossos do Braço/crescimento & desenvolvimento
Feto
Idade Gestacional
Ossos da Perna/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Ossos do Braço/diagnóstico por imagem
Estudos de Coortes
Diáfises/diagnóstico por imagem
Diáfises/crescimento & desenvolvimento
Feminino
Antropologia Forense
Seres Humanos
Análise dos Mínimos Quadrados
Ossos da Perna/diagnóstico por imagem
Masculino
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160603
[St] Status:MEDLINE
[do] DOI:10.1007/s00414-016-1393-5


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[PMID]:27080619
[Au] Autor:Maggio A; Flavel A; Hart R; Franklin D
[Ad] Endereço:Centre for Forensic Anatomy and Biological Sciences, School of Anatomy, Physiology and Human Biology, The University of Western Australia, 35 Stirling Highway, Crawley, Western Australia, Australia. Electronic address: akmaggio@outlook.com.au.
[Ti] Título:Skeletal age estimation in a contemporary Western Australian population using the Tanner-Whitehouse method.
[So] Source:Forensic Sci Int;263:e1-e8, 2016 06.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Various age estimation techniques have been utilised in Australia to evaluate the age of individuals who do not have documentation to determine legal majority/culpability. These age estimation techniques rely on the assessment of skeletal development as visualised in radiographs, CT scans, MRI or ultrasound modalities, and subsequent comparison to reference standards. These standards are not always population specific and are thus known to be less accurate when applied outside of the original reference sample, leading to potential ethical implications. Therefore, the present study aims to: (i) explore the variation in developmental trajectories between the established Tanner-Whitehouse (TW) age estimation standards and a Western Australian population; and (ii) develop specific hand-wrist age estimation standards for the latter population. The present study examines digital anterior-posterior hand-wrist radiographs of 360 individuals 0 to 24.9 years of age, equally represented by sex. Each radiograph was assessed using the RUS, Carpal and 20-bone methods of Tanner et al. The standard error of the estimate (SEE) was calculated for each method (range: ♀ SEE ±0.4-11.5 years; ♂ SEE ±0.9-10.1 years). The most accurate method was TW3 RUS for females and the TW2 Carpal system for males. The 50th centile skeletal maturity scores for each year age group were plotted against average chronological age to produce polynomial regression standards with a demonstrated accuracy of (♀ SEE ±0.09-3.46 years; ♂ SEE ±0.02-3.42 years) for females and males, respectively. The standards presented here can be used in future forensic investigations that require age estimation of hand-wrist bones in a Western Australian population, however, they are not appropriate for establishing age of majority (18 years), as skeletal maturity was attained on average earlier than 15 years of age in both sexes for all three systems examined.
[Mh] Termos MeSH primário: Determinação da Idade pelo Esqueleto/métodos
Ossos do Braço/diagnóstico por imagem
Ossos da Mão/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Ossos do Braço/crescimento & desenvolvimento
Austrália
Criança
Pré-Escolar
Feminino
Antropologia Forense
Ossos da Mão/crescimento & desenvolvimento
Seres Humanos
Lactente
Recém-Nascido
Masculino
Análise de Regressão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160416
[St] Status:MEDLINE


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[PMID]:26750990
[Au] Autor:Albanese J; Tuck A; Gomes J; Cardoso HF
[Ad] Endereço:Department of Sociology and Anthropology, University of Windsor, Windsor, Ontario, Canada; Centre for Forensic Research, Simon Fraser University, Burnaby, British Columbia, Canada. Electronic address: albanese@uwindsor.ca.
[Ti] Título:An alternative approach for estimating stature from long bones that is not population- or group-specific.
[So] Source:Forensic Sci Int;259:59-68, 2016 Feb.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:An accurate and precise estimate of stature can be very useful in the analysis of human remains in forensic cases. A problem with many stature estimation methods is that an unknown individual must first be assigned to a specific group before a method can be applied. Group membership has been defined by sex, age, year of birth, race, ancestry, continental origin, nationality or a combination of these criteria. Univariate and multivariate sex-specific and generic equations are presented here that do not require an unknown individual to be assigned to a group before stature is estimated. The equations were developed using linear regression with a sample (n=244) from the Terry Collection and tested using independent samples from the Forensic Anthropology Databank (n=136) and the Lisbon Collection (n=85). Tests with these independent samples show that (1) the femur provides the best univariate results; (2) the best multivariate equation includes the humerus, femur and tibia lengths; (3) a generic equation that does not require an unknown to first be assigned to a given category provides the best results most often; (4) a population-specific equation does not provide better results for estimating stature; (5) sex-specific equations can provide slightly better results in some cases; however, estimating the wrong sex can have a negative impact on precision and accuracy. With these equations, stature can be estimated independently of age at death, sex or group membership.
[Mh] Termos MeSH primário: Ossos do Braço/anatomia & histologia
Estatura
Ossos da Perna/anatomia & histologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Bases de Dados Factuais
Feminino
Fêmur/anatomia & histologia
Antropologia Forense/métodos
Seres Humanos
Úmero/anatomia & histologia
Masculino
Meia-Idade
Rádio (Anatomia)/anatomia & histologia
Tíbia/anatomia & histologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160112
[St] Status:MEDLINE


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[PMID]:25708121
[Au] Autor:Karlsson MK; Ahlborg HG; Svejme O; Nilsson JÅ; Rosengren BE
[Ad] Endereço:Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden; Department of Orthopaedics, Skane University Hospital, Malmö, Sweden. Electronic address: magnus.karlsson@med.lu.se.
[Ti] Título:An Increase in Forearm Cortical Bone Size After Menopause May Influence the Estimated Bone Mineral Loss--A 28-Year Prospective Observational Study.
[So] Source:J Clin Densitom;19(2):174-9, 2016 Apr-Jun.
[Is] ISSN:1094-6950
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Areal bone mineral density (aBMD) is the most common estimate of bone mass, incorporated in the World Health Organization definition of osteoporosis. However, aBMD depends on not only the amount of mineral but also the bone size. The estimated postmenopausal decline in aBMD could because of this be influenced by changes in bone size.We measured bone mineral content (BMC; mg), aBMD (mg/cm2), and bone width (mm) by single-photon absorptiometry at the cortical site of the forearm in a population-based sample of 105 Caucasian women. We conducted 12 measurements during a 28-yr period from mean 5 yr (range: 2-9) before menopause to mean 24 yr (range: 18-28) after menopause. We calculated individual slopes for changes in the periods before menopause, 0-<8, 8-<16, and 16-28 yr after menopause. Data are presented as means with 95% confidence intervals. The annual BMC changes in the 4 periods were -1.4% (-0.1, -2.6), -1.1% (-0.9, -1.4), -1.2% (-0.9, -1.6), and -1.1% (-0.8, -1.4) and the annual increase in bone width 0.4% (-1.2, 1.9), 0.7% (0.5, 0.9), 0.1% (-0.2, 0.4), and 0.1% (-0.2, 0.4). BMC loss was similar in all periods, whereas the increase in bone width was higher in the first postmenopausal period than in the second (p=0.003) and the third (p=0.01) postmenopausal periods. Menopause is followed by a transient increase in forearm bone size that will influence the by aBMD estimated cortical loss in bone minerals.
[Mh] Termos MeSH primário: Ossos do Braço/diagnóstico por imagem
Densidade Óssea
Antebraço
Osteoporose Pós-Menopausa
[Mh] Termos MeSH secundário: Absorciometria de Fóton/métodos
Idoso
Ossos do Braço/metabolismo
Ossos do Braço/patologia
Feminino
Seguimentos
Seres Humanos
Meia-Idade
Tamanho do Órgão
Osteoporose Pós-Menopausa/diagnóstico
Osteoporose Pós-Menopausa/epidemiologia
Osteoporose Pós-Menopausa/metabolismo
Pós-Menopausa
Estudos Prospectivos
Suécia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150225
[St] Status:MEDLINE


  10 / 137 MEDLINE  
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[PMID]:26636282
[Au] Autor:Dowthwaite JN; Dunsmore KA; Gero NM; Burzynski AO; Sames CA; Rosenbaum PF; Scerpella TA
[Ad] Endereço:Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY.
[Ti] Título:Arm bone loading index predicts DXA musculoskeletal outcomes in two samples of post-menarcheal girls.
[So] Source:J Musculoskelet Neuronal Interact;15(4):358-71, 2015 Dec.
[Is] ISSN:1108-7161
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: A site-specific bone loading index was developed to predict post-menarcheal arm bone mass, geometry, areal density and non-bone lean mass using organized activity records. METHODS: Two cohorts of post-menarcheal girls (A= 55, B= 48) met analysis inclusion criteria: (1) Whole body and non-dominant radius DXA scans +1.0 to +2.6 years post-menarche; (2) detailed, organized activity records available for 36 months prior to the focal DXA scan; (3) accompanying anthropometric data. DXA non-dominant arm and radius regions of interest (1/3, Ultradistal (UD)) were evaluated. An arm bone loading index (arm totBLI) was developed and refined to describe >50 activities. Separate regression analyses for Cohorts A&B tested explanatory value of arm totBLI for DXA outcomes, accounting for gynecological age, height and whole body non-bone lean mass. RESULTS: In both cohorts, arm totBLI reflecting 3 years of peri-menarcheal activity exposure exhibited strong explanatory value for post-menarcheal radius and arm outcomes (squared semi-partial r =0.07-0.34, p<0.05), except Arm Area. For both cohorts and most outcomes, arm totBLI explained significant variance, even after adjusting for local muscle mass. CONCLUSIONS: In two independent cohorts, arm totBLI may consistently indicate osteogenic and sarcogenic properties of represented activities; additional research is necessary for further refinement and validation.
[Mh] Termos MeSH primário: Antropometria/métodos
Ossos do Braço/fisiologia
Desenvolvimento Ósseo/fisiologia
Atividade Motora/fisiologia
Músculo Esquelético/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Absorciometria de Fóton
Adolescente
Composição Corporal/fisiologia
Criança
Feminino
Seres Humanos
Menarca
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151205
[St] Status:MEDLINE



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