Base de dados : MEDLINE
Pesquisa : A02.835.232.087.319.150 [Categoria DeCS]
Referências encontradas : 5024 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 503 ir para página                         

  1 / 5024 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29437062
[Au] Autor:Gaspar MP; Pham PP; Pankiw CD; Jacoby SM; Shin EK; Osterman AL; Kane PM
[Ad] Endereço:Philadelphia Hand to Shoulder Center, Thomas Jefferson University, 834 Chestnut Street, The Franklin Building, Suite G114, Philadelphia, PA 19107, USA and Darden School of Business, University of Virginia, 100 Darden Boulevard, Charlottesville, Virginia 22903, USA.
[Ti] Título:Mid-term outcomes of routine proximal row carpectomy compared with proximal row carpectomy with dorsal capsular interposition arthroplasty for the treatment of late-stage arthropathy of the wrist.
[So] Source:Bone Joint J;100-B(2):197-204, 2018 Feb.
[Is] ISSN:2049-4408
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: The aims of this study were to compare the mid-term outcomes of patients with late-stage arthritis of the wrist treated with proximal row carpectomy (PRC) and dorsal capsular interposition (DCI) arthroplasty with a matched cohort treated with routine PRC alone. PATIENTS AND METHODS: A total of 25 arthritic wrists (24 patients) with pre-existing degenerative changes of the proximal capitate and/or the lunate fossa of the radius were treated with PRC + DCI over a ten-year period. This group of patients were matched 1:2 with a group of 50 wrists (48 patients) without degenerative changes in the capitate or lunate fossa that were treated with a routine PRC alone during the same period. The mean age of the patients at the time of surgery was 56.8 years (25 to 81), and the demographics and baseline range of movement of the wrist, grip strength, Quick Disabilities of the Arm, Shoulder, and Hand (QuickDASH) score, and Patient-Rated Wrist Evaluation (PRWE) score were similar in both groups. RESULTS: At a mean follow-up of 5.9 years (1.8 to 11.8), significant improvements in mean grip strength, the flexion-extension arc of movement of the wrist, QuickDASH, and PRWE scores were seen in both groups. There was no diifference between the groups for any of the outcomes. One patient in the PRC + DCI group required additional surgery for a deep infection, while two in the PRC group had complications (one wound dehiscence requiring revision closure, one transient radial sensory neuritis). One patient in each group required total arthrodesis of the wrist for progressive degenerative radiocarpal changes. A total of 70 patients (93%) were satisfied with the outcomes. CONCLUSION: PRC with DCI is an effective form of treatment for late-stage arthritis of the wrist involving the capitolunate joint, with mid-term outcomes that are similar to those in patients without degenerative changes affecting the capitate or lunate fossa who are treated with a routine PRC alone. Cite this article: 2018;100-B:197-204.
[Mh] Termos MeSH primário: Artroplastia/métodos
Ossos do Carpo/cirurgia
Osteoartrite/cirurgia
Articulação do Punho/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Avaliação da Deficiência
Feminino
Seguimentos
Força da Mão
Seres Humanos
Masculino
Meia-Idade
Satisfação do Paciente
Amplitude de Movimento Articular
Retalhos Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180214
[St] Status:MEDLINE
[do] DOI:10.1302/0301-620X.100B2.BJJ-2017-0816.R2


  2 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29068934
[Au] Autor:Giacalone F; di Summa PG; Fenoglio A; Sard A; Dutto E; Ferrero M; Bertolini M; Garcia-Elias M
[Ad] Endereço:Turin, Italy; Lausanne, Switzerland; and Barcelona, Spain From the Department of Hand Surgery, CTO-Maria Adelaide Trauma and Orthopaedic Hospital; the Department of Plastic, Reconstructive, and Hand Surgery, Centre Hospitalier Universitaire Vaudois; and the Institut Kaplan.
[Ti] Título:Resurfacing Capitate Pyrocarbon Implant versus Proximal Row Carpectomy Alone: A Comparative Study to Evaluate the Role of Capitate Prosthetic Resurfacing in Advanced Carpal Collapse.
[So] Source:Plast Reconstr Surg;140(5):962-970, 2017 Nov.
[Is] ISSN:1529-4242
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The Resurfacing Capitate Pyrocarbon Implant associated with proximal row carpectomy has been used to treat symptomatic advanced carpal collapse, widening the indications of proximal row carpectomy to patients with capitate head arthritis. The authors retrospectively compared their case series of implant versus carpectomy alone, analyzing whether prosthetic implant outcomes could be similar to those of proximal row carpectomy even with a higher stage of osteoarthritis. METHODS: Fifty-seven patients who underwent surgery for wrist osteoarthritis (minimum follow-up, 2 years) were selected retrospectively. Twenty-five patients (scapholunate advanced collapse/scaphoid nonunion advanced collapse stage III to IV and Kienböck disease stage IV) underwent proximal row carpectomy plus Resurfacing Capitate Pyrocarbon Implant (group A); 32 patients (scapholunate advanced collapse/scaphoid nonunion advanced collapse stage I to II and Kienböck disease stage III) underwent carpectomy alone (group B). Mean follow-up was 33 months. Patients were evaluated clinically and radiographically. Patient-Rated Wrist Evaluation and Disabilities of the Arm, Shoulder, and Hand questionnaire scores were assessed. RESULTS: Group A showed consistent pain relief (visual analogue scale score of 2), while preserving wrist mobility (flexion, 27 degrees; extension, 33 degrees) and grip strength (54 percent compared with the contralateral side). Average Disabilities of the Arm, Shoulder, and Hand questionnaire score was 20, and average Patient-Rated Wrist Evaluation score was 28. No statistically significant difference was observed between groups for all outcomes, except for better extension (p < 0.05) in group B. CONCLUSIONS: Even starting from a higher grade of osteoarthritis, Resurfacing Capitate Pyrocarbon Implant plus proximal row carpectomy showed satisfying results, compared with those obtained with just carpectomy. Data show that indications for proximal row carpectomy can be widened by using the implant, without worsening outcomes. The implant could be a useful alternative to more aggressive salvage procedures in case of capitate head and lunate fossa osteoarthritis involvement. CLINICAL QUESTION/LEVEL OF EVIDENCE: Therapeutic, III.
[Mh] Termos MeSH primário: Artroplastia de Substituição/métodos
Carbono
Ossos do Carpo/cirurgia
Prótese Articular
Osteoartrite/cirurgia
Articulação do Punho/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Artroplastia de Substituição/instrumentação
Ossos do Carpo/diagnóstico por imagem
Ossos do Carpo/patologia
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Osteoartrite/diagnóstico por imagem
Osteoartrite/patologia
Radiografia
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (pyrolytic carbon); 7440-44-0 (Carbon)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/PRS.0000000000003759


  3 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28675805
[Au] Autor:Lazarus S; Tseng HW; Lawrence F; Woodruff MA; Duncan EL; Pettit AR
[Ad] Endereço:Translational Research Institute, Brisbane, Queensland, Australia; University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Endocrinology and Diabetes, Royal Brisbane and Women's Hospital, Brisbane, Queensland, A
[Ti] Título:Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
[So] Source:Am J Pathol;187(9):1923-1934, 2017 Sep.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multicentric carpal-tarsal osteolysis; multicentric osteolysis, nodulosis, and arthropathy; and Winchester syndromes, skeletal dysplasias characterized by carpal/tarsal and epiphyseal abnormalities, are caused by mutations in v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B (MAFB), matrix metalloproteinase (MMP) 2, and MMP14, respectively; however, the underlying pathophysiology is unclear. Osteoclast-mediated osteolysis has been regarded as the main mechanism, but does not explain the skeletal distribution. We hypothesized that MAFB, MMP-2, and MMP-14 have integral roles in carpal/tarsal and epiphyseal bone development. Normal neonatal mouse forepaws were imaged by micro-computed tomography and examined histologically. Murine forepaw ossification occurred sequentially. Subarticular regions of endochondral ossification showed morphologic and calcification patterns that were distinct from archetypical physeal endochondral ossification. This suggests that two different forms of endochondral ossification occur. The skeletal sites showing the greatest abnormality in the carpal-tarsal osteolysis syndromes are regions of subarticular ossification. Thus, abnormal bone formation in areas of subarticular ossification may explain the site-specific distribution of the carpal-tarsal osteolysis phenotype. MafB, Mmp-2, and Mmp-14 were expressed widely, and tartrate-resistant acid phosphatase staining notably was absent in the subarticular regions of the cartilage anlagen and entheses at a time point most relevant to the human osteolysis syndromes. Thus, abnormal peri-articular skeletal development and modeling, rather than excessive bone resorption, may be the underlying pathophysiology of these skeletal syndromes.
[Mh] Termos MeSH primário: Ossos do Carpo/crescimento & desenvolvimento
Lâmina de Crescimento/patologia
Osteólise/patologia
[Mh] Termos MeSH secundário: Animais
Proteínas de Arabidopsis
Ossos do Carpo/diagnóstico por imagem
Ossos do Carpo/metabolismo
Pré-Escolar
Lâmina de Crescimento/diagnóstico por imagem
Lâmina de Crescimento/metabolismo
Seres Humanos
Liases Intramoleculares
Fator de Transcrição MafB/metabolismo
Metaloproteinase 14 da Matriz/metabolismo
Metaloproteinase 2 da Matriz/metabolismo
Camundongos
Osteogênese
Osteólise/diagnóstico por imagem
Osteólise/metabolismo
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (MafB Transcription Factor); 0 (Mafb protein, mouse); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.80 (Matrix Metalloproteinase 14); EC 5.5.- (Intramolecular Lyases); EC 5.5.1.6 (CHIL protein, Arabidopsis)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


  4 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28650233
[Au] Autor:Zetterström SM; Johansson BC; Carmalt JL
[Ti] Título:Evaluation of clinical and tenoscopic findings in the carpal flexor sheath of horses.
[So] Source:Am J Vet Res;78(7):840-846, 2017 Jul.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To evaluate clinical and tenoscopic findings in a large group of horses undergoing surgery of the carpal flexor sheath (CFS) and determine whether any of the presurgical clinical signs were associated with tenoscopic findings. ANIMALS 242 horses that had undergone diagnostic and therapeutic tenoscopy of the CFS because of aseptic tenosynovitis. PROCEDURES Medical and tenoscopic video records (when available) of 242 horses undergoing tenoscopy of the CFS at a single equine clinic between January 2005 and June 2014 were reviewed. Tenoscopic findings were categorized as present or absent, and tears in the deep digital flexor tendon (DDFT) were subjectively graded according to severity. Logistic regression analysis was used to examine whether presurgical clinical findings were associated with intraoperative tenoscopic findings. RESULTS 242 horses (411 limbs) were evaluated by use of tenoscopy. An exostosis was detected in 228 horses (379 limbs) and was often multipartite. Most exostoses were found medial to, or within, the sagittal plane at the caudal margin of the scar on the distal physis of the radius. Effusion in the CFS was associated with tears in the DDFT. Other presurgical clinical findings were not predictive of intrathecal findings. CONCLUSIONS AND CLINICAL RELEVANCE Synovial effusion was predictive of DDFT lesions within the CFS but was not predictive of the severity of lesions. Further studies will be necessary to determine whether any tenoscopic findings are associated with reduced athletic performance and to assess the effect of surgical intervention in affected horses.
[Mh] Termos MeSH primário: Endoscopia/veterinária
Doenças dos Cavalos/patologia
Tendões/patologia
Tenossinovite/veterinária
[Mh] Termos MeSH secundário: Animais
Ossos do Carpo
Endoscopia/métodos
Feminino
Doenças dos Cavalos/diagnóstico por imagem
Cavalos
Coxeadura Animal/patologia
Masculino
Rádio (Anatomia)
Estudos Retrospectivos
Tenossinovite/diagnóstico por imagem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.7.840


  5 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28628532
[Au] Autor:Burnham R; Playfair L; Loh E; Roberts S; Agur A
[Ad] Endereço:From the Central Alberta Pain and Rehabilitation Institute, Lacombe (RB, LP); Division of Physical Medicine and Rehabilitation, University of Alberta, Edmonton (RB), Alberta; Department of Physical Medicine and Rehabilitation, Parkwood Institute, Western University, London (EL); and Division of Anatomy, Department of Surgery (SR, AA), and Division of Physical Medicine and Rehabilitation (AA), University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Evaluation of the Effectiveness and Safety of Ultrasound-Guided Percutaneous Carpal Tunnel Release: A Cadaveric Study.
[So] Source:Am J Phys Med Rehabil;96(7):457-463, 2017 Jul.
[Is] ISSN:1537-7385
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The looped thread carpal tunnel release (TCTR) procedure is a minimally invasive percutaneous technique performed under ultrasound (US) to transect the transverse carpal ligament in patients with carpal tunnel syndrome. Study objectives were to evaluate the accuracy of identifying key US landmarks, safety, effectiveness, and technical difficulty of TCTR. DESIGN: Fourteen lightly embalmed cadaveric distal forearm-hand specimens were subject to US identification of key landmarks, TCTR procedure, and post-TCTR dissection. Outcome measures of interest were (1) correspondence between key landmarks (median nerve and 4 bony pillars of transverse carpal ligament) identified on US and anatomical structures exposed by dissection, (2) percentage of the transverse carpal ligament transected and location of the transection, (3) frequency of damage to adjacent structures, (4) time to complete procedure, and (5) operator assessment of technical difficulty of each TCTR procedure (0 = extremely easy, 10 = extremely difficult). RESULTS: (1) Skin markings delineating the position of US-visualized landmarks corresponded almost perfectly to anatomical dissection. (2) Nine (64.2%) of 14 specimens had complete division of the transverse carpal ligament. In the remaining 5 specimens, an average of 68.8% of the ligament was transected. (3) No adjacent structures were damaged. (4) Time to complete the procedure was on average 9.9 ± 4.6 minutes. (5) Average procedural difficulty was 4.3/10. CONCLUSIONS: Thread carpal tunnel release is potentially a safe, quick, and effective procedure to transect the transverse carpal ligament. Future clinical investigation is recommended.
[Mh] Termos MeSH primário: Pontos de Referência Anatômicos/cirurgia
Síndrome do Túnel Carpal/cirurgia
Dissecação/métodos
Ultrassonografia de Intervenção/métodos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Cadáver
Ossos do Carpo/anatomia & histologia
Ossos do Carpo/cirurgia
Feminino
Seres Humanos
Ligamentos Articulares/anatomia & histologia
Ligamentos Articulares/cirurgia
Masculino
Nervo Mediano/anatomia & histologia
Nervo Mediano/cirurgia
Articulação do Punho/anatomia & histologia
Articulação do Punho/cirurgia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170823
[Lr] Data última revisão:
170823
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170620
[St] Status:MEDLINE
[do] DOI:10.1097/PHM.0000000000000652


  6 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28504915
[Au] Autor:Greditzer HG; Hutchinson ID; Geannette CS; Hotchkiss RN; Kelly BT; Potter HG
[Ad] Endereço:Department of Radiology & Imaging, Hospital for Special Surgery, New York, New York.
[Ti] Título:Prevalence of Os Styloideum in National Hockey League Players.
[So] Source:Sports Health;9(5):469-473, 2017 Sep/Oct.
[Is] ISSN:1941-0921
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Os styloideum describes an accessory carpal ossicle between the trapezoid, the capitate, and the second and third metacarpals. Injuries to this tissue have been described as part of the carpal boss syndrome. While the etiology of os styloideum remains uncertain, it may represent a physiologic response to altered loading forces in the wrist, similar to the development of cam-type deformity in the hips of ice hockey players or the Bennett lesion in the shoulders of baseball pitchers. HYPOTHESIS: Professional hockey players will have a higher prevalence of os styloideum compared with the general population. STUDY DESIGN: Case series. LEVEL OF EVIDENCE: Level 4. METHODS: A retrospective review of 16 professional hockey players from 4 different National Hockey League (NHL) teams who underwent unilateral imaging of the wrist was performed. Seventeen wrists were reviewed for the presence of os styloideum. RESULTS: Thirteen of 16 players (81%) had an os styloideum, representing an increased prevalence compared with the general population. Previous clinical and cadaveric studies estimated a general prevalence of up to 19% ( P < 0.001). For the 10 players who had their leading wrist scanned, 9 had an os styloideum (90%). Ten of 11 (91%) players demonstrated a bone marrow edema pattern within the metacarpal and the os styloideum on magnetic resonance imaging. There was no significant association between the presence of an os styloideum and the player's position, leading wrist, or years in the league. CONCLUSION: There appears to be an increased prevalence of os styloideum among NHL players, and team physicians should consider this finding while formulating a differential diagnosis for dorsal wrist pain. CLINICAL RELEVANCE: This study identified NHL players as having an increased prevalence of os styloideum compared with the general population. By doing so, these findings represent an opportunity to enhance our understanding of the etiology, clinical significance, and treatment of os styloideum.
[Mh] Termos MeSH primário: Ossos do Carpo/diagnóstico por imagem
Ossos do Carpo/patologia
Hóquei
[Mh] Termos MeSH secundário: Adulto
Artralgia/etiologia
Artralgia/terapia
Ossos do Carpo/fisiopatologia
Hóquei/fisiologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Radiografia
Estudos Retrospectivos
Tomografia Computadorizada por Raios X
Suporte de Carga
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE
[do] DOI:10.1177/1941738117707914


  7 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28229185
[Au] Autor:Cortese J; Soubeyrand M; Razakamanantsoa L; Bellin MF; Creze M
[Ad] Endereço:Radiology Department, Hôpital Bicêtre, 78 rue du Général Leclerc, 94266, Le Kremlin-Bicetre, France. jon.cortese@live.fr.
[Ti] Título:Hamate and pisiform coalition: a case report and introduction to the carpal C-sign on lateral radiograph.
[So] Source:Skeletal Radiol;46(5):693-699, 2017 May.
[Is] ISSN:1432-2161
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Hamate-pisiform coalition is an exceptional form of carpal coalition. Case reports are essential to gain a better understanding of this variant. We report a case of congenital bilateral hamate-pisiform coalition in a 20-year-old male discovered in the context of a right wrist trauma. Radiographs also revealed a bilateral scapholunate diastasis. Clinical examination and radiological findings suggested that the right wrist scapholunate diastasis was related to scapholunate instability. Left wrist scapholunate diastasis could be related to (1) a pathological feature or (2) a normal variant associated with hamate-pisiform coalition. Lateral radiographs showed a volar C-shaped osseous bridge corresponding to the coalition. We associated it with a new sign: the "carpal C-sign". Computed tomography with three-dimensional reconstruction provides helpful information about the type of coalition (osseous versus non-osseous) and excludes potential fracture. We discuss the specific embryologic features of the hamate-pisiform coalition, as well as its prevalence, radiographic classification, clinical significance, and treatment.
[Mh] Termos MeSH primário: Hamato/diagnóstico por imagem
Ligamentos Articulares/lesões
Ligamentos Articulares/cirurgia
Pisciforme/diagnóstico por imagem
Traumatismos do Punho/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Ossos do Carpo
Meios de Contraste
Diagnóstico Diferencial
Seres Humanos
Imagem Tridimensional/métodos
Ligamentos Articulares/diagnóstico por imagem
Masculino
Tomografia Computadorizada Multidetectores/métodos
Intensificação de Imagem Radiográfica/métodos
Radiografia/métodos
Articulação do Punho/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1007/s00256-017-2593-x


  8 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28169396
[Au] Autor:Tang L; Wu X; Zhang H; Lu S; Wu M; Shen C; Chen X; Wang Y; Wang W; Shen Y; Gu M; Ding X; Jin X; Fei J; Wang Z
[Ad] Endereço:State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, P.R. China.
[Ti] Título:A point mutation in Fgf9 impedes joint interzone formation leading to multiple synostoses syndrome.
[So] Source:Hum Mol Genet;26(7):1280-1293, 2017 Apr 01.
[Is] ISSN:1460-2083
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Human multiple synostoses syndrome (SYNS) is an autosomal dominant disorder characterized by multiple joint fusions. We previously identified a point mutation (S99N) in FGF9 that causes human SYNS3. However, the physiological function of FGF9 during joint development and comprehensive molecular portraits of SYNS3 remain elusive. Here, we report that mice harboring the S99N mutation in Fgf9 develop the curly tail phenotype and partially or fully fused caudal vertebrae and limb joints, which mimic the major phenotypes of SYNS3 patients. Further study reveals that the S99N mutation in Fgf9 disrupts joint interzone formation by affecting the chondrogenic differentiation of mesenchymal cells at the early stage of joint development. Consistently, the limb bud micromass culture (LBMMC) assay shows that Fgf9 inhibits mesenchymal cell differentiation into chondrocytes by downregulating the expression of Sox6 and Sox9. However, the mutant protein does not exhibit the same inhibitory effect. We also show that Fgf9 is required for normal expression of Gdf5 in the prospective elbow and knee joints through its activation of Gdf5 promoter activity. Signal transduction assays indicate that the S99N mutation diminishes FGF signaling in developmental limb joints. Finally, we demonstrate that the conformational change in FGF9 resulting from the S99N mutation disrupts FGF9/FGFR/heparin interaction, which impedes FGF signaling in developmental joints. Taken together, we conclude that the S99N mutation in Fgf9 causes SYNS3 via the disturbance of joint interzone formation. These results further implicate the crucial role of Fgf9 during embryonic joint development.
[Mh] Termos MeSH primário: Ossos do Carpo/anormalidades
Diferenciação Celular/genética
Fator 9 de Crescimento de Fibroblastos/genética
Deformidades Congênitas do Pé/genética
Deformidades Congênitas da Mão/genética
Estribo/anormalidades
Sinostose/genética
Ossos do Tarso/anormalidades
[Mh] Termos MeSH secundário: Animais
Ossos do Carpo/fisiopatologia
Condrogênese/genética
Fator 9 de Crescimento de Fibroblastos/biossíntese
Fator 9 de Crescimento de Fibroblastos/química
Deformidades Congênitas do Pé/fisiopatologia
Regulação da Expressão Gênica no Desenvolvimento
Fator 5 de Diferenciação de Crescimento/genética
Deformidades Congênitas da Mão/fisiopatologia
Seres Humanos
Articulações/crescimento & desenvolvimento
Articulações/patologia
Camundongos
Mutação Puntual
Conformação Proteica
Fatores de Transcrição SOX9/genética
Fatores de Transcrição SOXD/genética
Transdução de Sinais
Estribo/fisiopatologia
Sinostose/fisiopatologia
Ossos do Tarso/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (FGF9 protein, human); 0 (Fgf9 protein, mouse); 0 (Fibroblast Growth Factor 9); 0 (Gdf5 protein, mouse); 0 (Growth Differentiation Factor 5); 0 (SOX9 Transcription Factor); 0 (SOXD Transcription Factors); 0 (Sox6 protein, mouse); 0 (Sox9 protein, mouse)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170208
[St] Status:MEDLINE
[do] DOI:10.1093/hmg/ddx029


  9 / 5024 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28099304
[Au] Autor:Schwarcz Y; Schwarcz Y; Peleg E; Joskowicz L; Wollstein R; Luria S
[Ad] Endereço:1Department of Orthopaedic Surgery, Hadassah-Hebrew University Medical Center, Jerusalem, Israel 2School of Engineering and Computer Science, the Hebrew University, Jerusalem, Israel 3University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
[Ti] Título:Three-Dimensional Analysis of Acute Scaphoid Fracture Displacement: Proximal Extension Deformity of the Scaphoid.
[So] Source:J Bone Joint Surg Am;99(2):141-149, 2017 Jan 18.
[Is] ISSN:1535-1386
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Our goal was to analyze the movement of acute scaphoid waist fracture fragments and adjacent bones in a common coordinate system. Our hypothesis was that the distal scaphoid fragment flexes and pronates and the proximal fragment extends. METHODS: Computed tomography (CT) scans of patients diagnosed with an acute scaphoid waist fracture were evaluated using a 3-dimensional (3D) model. The scans of 57 nondisplaced and 23 displaced fractures were compared with a control group of 27 scans showing no pathological involvement of the wrist. Three anatomical landmarks were labeled on the distal and proximal fragments of the scaphoid, the lunate, and the trapezium. Each set of labels formed a triangle representing the bone or fragment. Four landmarks were labeled on the distal radial articular surface and used to create a common coordinate system. The position of each bone or fragment was calculated in reference to these coordinates. RESULTS: The displaced fracture group showed significant extension, supination, and volar translation of the proximal scaphoid fragment when compared with the other groups. The lunate tended toward a supinated position, which was not statistically significant. The distal scaphoid fragment and the trapezium showed no movement. CONCLUSIONS: In acute displaced scaphoid fractures, it is the proximal fragment that displaces and should be reduced. CLINICAL RELEVANCE: The typical "humpback" deformity is actually a "proximal extension" deformity, the consequence of displacement of the proximal fragment of the scaphoid (with the lunate). Manipulating only the proximal fragment (with the lunate) may be technically easier and more effective than manipulating both fragments.
[Mh] Termos MeSH primário: Fraturas Ósseas/diagnóstico por imagem
Osso Escafoide/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Análise de Variância
Pontos de Referência Anatômicos
Ossos do Carpo/diagnóstico por imagem
Fraturas Ósseas/fisiopatologia
Seres Humanos
Imagem Tridimensional
Meia-Idade
Variações Dependentes do Observador
Pronação/fisiologia
Tomografia Computadorizada por Raios X/métodos
Articulação do Punho/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.2106/JBJS.16.00021


  10 / 5024 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28073093
[Au] Autor:Walia P; Erdemir A; Li ZM
[Ad] Endereço:Hand Research Laboratory, Cleveland Clinic, Cleveland, OH, United States; Department of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, United States.
[Ti] Título:Subject-specific finite element analysis of the carpal tunnel cross-sectional to examine tunnel area changes in response to carpal arch loading.
[So] Source:Clin Biomech (Bristol, Avon);42:25-30, 2017 Feb.
[Is] ISSN:1879-1271
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Manipulating the carpal arch width (i.e. distance between hamate and trapezium bones) has been suggested as a means to increase carpal tunnel cross-sectional area and alleviate median nerve compression. The purpose of this study was to develop a finite element model of the carpal tunnel and to determine an optimal force direction to maximize area. METHODS: A planar geometric model of carpal bones at hamate level was reconstructed from MRI with inter-carpal joint spaces filled with a linear elastic surrogate tissue. Experimental data with discrete carpal tunnel pressures (50, 100, 150, and 200mmHg) and corresponding carpal bone movements were used to obtain material property of surrogate tissue by inverse finite element analysis. The resulting model was used to simulate changes of carpal arch widths and areas with directional variations of a unit force applied at the hook of hamate. FINDINGS: Inverse finite element model predicted the experimental area data within 1.5% error. Simulation of force applications showed that carpal arch width and area were dependent on the direction of force application, and minimal arch width and maximal area occurred at 138° (i.e. volar-radial direction) with respect to the hamate-to-trapezium axis. At this force direction, the width changed to 24.4mm from its initial 25.1mm (3% decrease), and the area changed to 301.6mm from 290.3mm (4% increase). INTERPRETATION: The findings of the current study guide biomechanical manipulation to gain tunnel area increase, potentially helping reduce carpal tunnel pressure and relieve symptoms of compression median neuropathy.
[Mh] Termos MeSH primário: Síndrome do Túnel Carpal/fisiopatologia
Articulação do Punho/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Fenômenos Biomecânicos
Ossos do Carpo/fisiologia
Feminino
Análise de Elementos Finitos
Seres Humanos
Imagem por Ressonância Magnética
Nervo Mediano/fisiologia
Modelos Biológicos
Tendões/fisiologia
Trapézio/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE



página 1 de 503 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde