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Pesquisa : A02.835.232.251.352 [Categoria DeCS]
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[PMID]:27770721
[Au] Autor:Fan F; Zhang K; Peng Z; Cui JH; Hu N; Deng ZH
[Ad] Endereço:Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
[Ti] Título:Forensic age estimation of living persons from the knee: Comparison of MRI with radiographs.
[So] Source:Forensic Sci Int;268:145-150, 2016 Nov.
[Is] ISSN:1872-6283
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:To perform a study to clarify how strong the chronological age relates to ossification of the knee in Chinese on X-rays and the MRI when a similar four-stage grading system was used. 322 individuals with conventional radiographs and MRI were collected from routine medical investigations and evaluated retrospectively. Bland Altman plots were performed to reveal the agreement of grading of MRI and radiograph. Regression analysis was conducted to establish a mathematical model for age estimation. The ossification process of the knee occurs earlier in females than in males for about 1-2 years. The process on X-ray grading is consistently higher than that of MRI. The chronological age is well correlated with both grading of MRI and radiograph (all p values were less than 0.001). By comparison, the R-square of grading of MRI were relatively higher than that of radiograph. Finally, the chronological age is well correlated with the ossification of the knee when both grading of MRI and radiograph were used, with the R-square for MRI were relatively higher than that of radiograph. Furthermore, the use of MRI will reduce exposure to X-ray radiation as much as possible.
[Mh] Termos MeSH primário: Determinação da Idade pelo Esqueleto/métodos
Articulação do Joelho/diagnóstico por imagem
Articulação do Joelho/crescimento & desenvolvimento
Osteogênese
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Epífises/diagnóstico por imagem
Epífises/crescimento & desenvolvimento
Feminino
Antropologia Forense
Lâmina de Crescimento/diagnóstico por imagem
Lâmina de Crescimento/crescimento & desenvolvimento
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Radiografia
Análise de Regressão
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE


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[PMID]:29182121
[Au] Autor:Agarwal A; Gupta N; Mishra M; Agrawal N; Kumar D
[Ti] Título:Primary epiphyseal and metaepiphyseal tubercular osteomyelitis in children A series of 8 case.
[So] Source:Acta Orthop Belg;82(4):797-805, 2016 Dec.
[Is] ISSN:0001-6462
[Cp] País de publicação:Belgium
[La] Idioma:eng
[Ab] Resumo:Clinical series of primary epiphyseal and metaepiphyseal tubercular osteomyelitis are few. The purpose of our study was to retrospectively review the presentation, healing response and functional results of 8 such cases in children. MATERIAL AND METHODS: The patients were evaluated for pain, deformity, range of motion, limb length discrepancy (if any) and recurrence. Serial radiographs of the region were studied to see remineralization, obliteration of radiological lesions, status of physis and remodeling of the growth plate. RESULTS: The mean patient age was 7.1 years. Average follow up was 3.7 years. The mean duration of symptom before presentation was 2.9 months (range, 0.5-8 months). Knee region was involved in 4, distal radius in 2, shoulder and distal fibula in 1 patient each. The lesions were either localized or diffuse depending upon physeal involvement and osseous destruction. At the last follow up, the involved joints were painfree and had useful range of motion. Limb length lengthening was seen in all knee patients. The diffuse variety resulted in premature physeal closure. The residual lucencies persisted for several years without any clinical manifestations. CONCLUSIONS: Primary epiphyseal and metaepiphyseal tuberculosis was relatively uncommon. The clinical outcome was good following curettage and multidrug antitubercular therapy. The epiphyseal and metaphyseal lucencies persisted for several months even after successful treatment. The diffuse variety lead to premature physeal closure. Limb length lengthening was common sequelae of tuberculosis of knee region.
[Mh] Termos MeSH primário: Antituberculosos/uso terapêutico
Curetagem/métodos
Epífises/cirurgia
Articulação do Joelho/cirurgia
Osteomielite/terapia
Tuberculose Osteoarticular/terapia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Epífises/diagnóstico por imagem
Feminino
Seguimentos
Lâmina de Crescimento
Seres Humanos
Articulação do Joelho/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Osteomielite/diagnóstico por imagem
Radiografia
Estudos Retrospectivos
Resultado do Tratamento
Tuberculose Osteoarticular/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antitubercular Agents)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


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[PMID]:29190650
[Au] Autor:Stalvey MS; Havasi V; Tuggle KL; Wang D; Birket S; Rowe SM; Sorscher EJ
[Ad] Endereço:Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, United States of America.
[Ti] Título:Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat.
[So] Source:PLoS One;12(11):e0188497, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Reduced growth and osteopenia are common in individuals with cystic fibrosis (CF). Additionally, improved weight and height are associated with better lung function and overall health in the disease. Mechanisms for this reduction in growth are not understood. We utilized a new CFTR knockout rat to evaluate growth in young CF animals, via femur length, microarchitecture of bone and growth plate, as well as serum IGF-I concentrations. METHODS: Femur length was measured in wild-type (WT) and SD-CFTRtm1sage (Cftr-/-) rats, as a surrogate marker for growth. Quantitative bone parameters in Cftr-/- and WT rats were measured by micro computed tomography (micro-CT). Bone histomorphometry and cartilaginous growth plates were analyzed. Serum IGF-I concentrations were also compared. RESULTS: Femur length was reduced in both Cftr-/- male and female rats compared to WT. Multiple parameters of bone microarchitecture (of both trabecular and cortical bone) were adversely affected in Cftr-/- rats. There was a reduction in overall growth plate thichkness in both male and female Cftr-/- rats, as well as hypertrophic zone thickness and mean hypertrophic cell volume in male rats, indicating abnormal growth characteristics at the plate. Serum IGF-I concentrations were severely reduced in Cftr-/- rats compared to WT littermates. CONCLUSIONS: Despite absence of overt lung or pancreatic disease, reduced growth and bone content were readily detected in young Cftr-/- rats. Reduced size of the growth plate and decreased IGF-I concentrations suggest the mechanistic basis for this phenotype. These findings appear to be intrinsic to the CFTR deficient state and independent of significant clinical confounders, providing substantive evidence for the importance of CFTR on maintinaing normal bone growth.
[Mh] Termos MeSH primário: Desenvolvimento Ósseo
Regulador de Condutância Transmembrana em Fibrose Cística/genética
Fibrose Cística/patologia
Lâmina de Crescimento/patologia
Fator de Crescimento Insulin-Like I/metabolismo
[Mh] Termos MeSH secundário: Animais
Fibrose Cística/metabolismo
Modelos Animais de Doenças
Feminino
Técnicas de Silenciamento de Genes
Lâmina de Crescimento/metabolismo
Masculino
Ratos
Ratos Sprague-Dawley
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CFTR protein, rat); 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator); 67763-96-6 (Insulin-Like Growth Factor I)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188497


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[PMID]:28470772
[Au] Autor:Martel G; Forget C; Gilbert G; Richard H; Moser T; Olive J; Laverty S
[Ad] Endereço:Département des Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, St-Hyacinthe, Quebec, Canada.
[Ti] Título:Validation of the ultrasonographic assessment of the femoral trochlea epiphyseal cartilage in foals at osteochondrosis predilected sites with magnetic resonance imaging and histology.
[So] Source:Equine Vet J;49(6):821-828, 2017 Nov.
[Is] ISSN:2042-3306
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Noninvasive imaging tools are needed to screen foal femoropatellar joints to detect subclinical osteochondrosis lesions due to focal failure of endochondral ossification to enhance early management to optimise intrinsic healing events. Recently investigations employing 3T susceptibility-weighted magnetic resonance imaging (3T SWI MRI) and CT have demonstrated their capacity for early osteochondrosis diagnosis, but these technologies are not practical for field screening. We postulate that ultrasonography is a valuable field tool for the detection of subclinical osteochondrosis lesions. OBJECTIVES: The goals were to 1) describe the ultrasonographic features of the femoral trochlea of healthy and osteochondrosis-predisposed neonatal foals, 2) validate the capacity of ultrasound to assess cartilage canal vascular archictecture and the ossification front and 3) evaluate field feasibility in a pilot study. STUDY DESIGN: Experimental study. METHODS: Ultrasonographic evaluation of osteochondrosis predisposed (n = 10) and control (n = 6) femoral trochleas was performed ex vivo and compared with site-matched histological sections and 3T SWI MRI. The articular and epiphyseal cartilage thickness, ossification front indentation and cartilage canal vascular archictecture were assessed at each ROI. Femoral trochleae of foals (n = 3) aged ≈ 1, 3 and 6 months were also evaluated with ultrasonography in field. RESULTS: Ultrasonographic measurements strongly correlated with the histological measurements. There was no difference in the cartilage thickness or ossification front indentation between control and osteochondrosis-predisposed specimens. The cartilage canal vascular archictecture on ultrasonograms corresponded with the vessel pattern observed on site matched histology and 3T SWI MRI. MAIN LIMITATIONS: The number of specimens for study was limited and no early osteochondrosis lesions were present within the predilected group, but a field study is now underway. CONCLUSION: Ultrasonographic examination of the femoral trochlea permitted accurate evaluation of cartilage thickness, cartilage canal vascular archictecture and ossification front indentation in young foals and is a promising, practical tool for screening subclinical osteochondrosis and monitoring and managing lesions at important clinical sites.
[Mh] Termos MeSH primário: Fêmur/diagnóstico por imagem
Lâmina de Crescimento/diagnóstico por imagem
Doenças dos Cavalos/diagnóstico por imagem
Osteocondrose/veterinária
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Feminino
Cavalos
Imagem por Ressonância Magnética/veterinária
Masculino
Osteocondrose/diagnóstico por imagem
Ultrassonografia/normas
Ultrassonografia/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/evj.12698


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[PMID]:28977598
[Au] Autor:Suzuki D; Bush JR; Bryce DM; Kamijo R; Beier F
[Ad] Endereço:Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A 5C1, Canada.
[Ti] Título:Rac1 Dosage Is Crucial for Normal Endochondral Bone Growth.
[So] Source:Endocrinology;158(10):3386-3398, 2017 Oct 01.
[Is] ISSN:1945-7170
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rac1, a member of the small Rho GTPase family, plays multiple cellular roles. Studies of mice conditionally lacking Rac1 have revealed essential roles for Rac1 in various tissues, including cartilage and limb mesenchyme, where Rac1 loss produces dwarfism and long bone shortening. To gain further insight into the role of Rac1 in skeletal development, we have used transgenic mouse lines to express a constitutively active (ca) Rac1 mutant protein in a Cre recombinase-dependent manner. Overexpression of caRac1 in limb bud mesenchyme or chondrocytes leads to reduced body weight and shorter bones compared with control mice. Histological analysis of growth plates showed that caRac1;Col2-Cre mice displayed ectopic hypertrophic chondrocytes in the proliferative zone and enlarged hypertrophic zones. These mice also displayed a reduced proportion of proliferating cell nuclear antigen-positive cells in the proliferative zone and nuclear ß-catenin localization in the ectopic hypertrophic chondrocytes. Importantly, overexpression of caRac1 partially rescued the phenotypes of Rac1fl/fl;Col2-Cre and Rac1fl/fl;Prx1-Cre conditional knockout mice, including body weight, bone length, and growth plate disorganization. These results suggest that tight regulation of Rac1 activity is necessary for normal cartilage development.
[Mh] Termos MeSH primário: Desenvolvimento Ósseo/genética
Osso e Ossos/patologia
Cartilagem/metabolismo
Neuropeptídeos/genética
Proteínas rac1 de Ligação ao GTP/genética
[Mh] Termos MeSH secundário: Animais
Western Blotting
Peso Corporal/genética
Osso e Ossos/metabolismo
Cartilagem/patologia
Condrócitos/metabolismo
Condrócitos/patologia
Feminino
Dosagem de Genes
Regulação da Expressão Gênica no Desenvolvimento
Lâmina de Crescimento
Hipertrofia
Imuno-Histoquímica
Hibridização In Situ
Marcação In Situ das Extremidades Cortadas
Masculino
Mesoderma/metabolismo
Camundongos
Camundongos Knockout
Camundongos Transgênicos
Tamanho do Órgão/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (CTNNB1 protein, mouse); 0 (Neuropeptides); 0 (Rac1 protein, mouse); 0 (beta Catenin); EC 3.6.5.2 (rac1 GTP-Binding Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1210/en.2016-1691


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[PMID]:28974642
[Au] Autor:Uchimura T; Hollander JM; Nakamura DS; Liu Z; Rosen CJ; Georgakoudi I; Zeng L
[Ad] Endereço:Program in Cell, Molecular and Developmental Biology, Sackler School of Graduate Biomedical Sciences, Tufts University, 136 Harrison Avenue, Boston, MA 02111, USA.
[Ti] Título:An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth.
[So] Source:Development;144(19):3533-3546, 2017 10 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Postnatal bone growth involves a dramatic increase in length and girth. Intriguingly, this period of growth is independent of growth hormone and the underlying mechanism is poorly understood. Recently, an mutation was identified in humans with early postnatal growth restriction. Here, we show that IGF2 is essential for longitudinal and appositional murine postnatal bone development, which involves proper timing of chondrocyte maturation and perichondrial cell differentiation and survival. Importantly, the null mouse model does not represent a simple delay of growth but instead uncoordinated growth plate development. Furthermore, biochemical and two-photon imaging analyses identified elevated and imbalanced glucose metabolism in the null mouse. Attenuation of glycolysis rescued the mutant phenotype of premature cartilage maturation, thereby indicating that IGF2 controls bone growth by regulating glucose metabolism in chondrocytes. This work links glucose metabolism with cartilage development and provides insight into the fundamental understanding of human growth abnormalities.
[Mh] Termos MeSH primário: Desenvolvimento Ósseo/genética
Cartilagem/embriologia
Cartilagem/metabolismo
Condrogênese
Glucose/metabolismo
Fator de Crescimento Insulin-Like II/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Diferenciação Celular
Condrócitos/metabolismo
Condrócitos/patologia
Condrogênese/genética
Regulação da Expressão Gênica no Desenvolvimento
Glicólise
Lâmina de Crescimento/metabolismo
Lâmina de Crescimento/patologia
Hipertrofia
Camundongos
Modelos Biológicos
Mutação/genética
Técnicas de Cultura de Órgãos
Fenótipo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
67763-97-7 (Insulin-Like Growth Factor II); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171005
[St] Status:MEDLINE
[do] DOI:10.1242/dev.155598


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[PMID]:28851708
[Au] Autor:Bluhm B; Ehlen HWA; Holzer T; Georgieva VS; Heilig J; Pitzler L; Etich J; Bortecen T; Frie C; Probst K; Niehoff A; Belluoccio D; Van den Bergen J; Brachvogel B
[Ad] Endereço:Department of Pediatrics and Adolescent Medicine, Experimental Neonatology, Medical Faculty, University of Cologne, Cologne 50931, Germany.
[Ti] Título:miR-322 stabilizes MEK1 expression to inhibit RAF/MEK/ERK pathway activation in cartilage.
[So] Source:Development;144(19):3562-3577, 2017 10 01.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Cartilage originates from mesenchymal cell condensations that differentiate into chondrocytes of transient growth plate cartilage or permanent cartilage of the articular joint surface and trachea. MicroRNAs fine-tune the activation of entire signaling networks and thereby modulate complex cellular responses, but so far only limited data are available on miRNAs that regulate cartilage development. Here, we characterize a miRNA that promotes the biosynthesis of a key component in the RAF/MEK/ERK pathway in cartilage. Specifically, by transcriptome profiling we identified miR-322 to be upregulated during chondrocyte differentiation. Among the various miR-322 target genes in the RAF/MEK/ERK pathway, only was identified as a regulated target in chondrocytes. Surprisingly, an increased concentration of miR-322 stabilizes mRNA to raise protein levels and dampen ERK1/2 phosphorylation, while cartilage-specific inactivation of miR322 in mice linked the loss of miR-322 to decreased MEK1 levels and to increased RAF/MEK/ERK pathway activation. Such mice died perinatally due to tracheal growth restriction and respiratory failure. Hence, a single miRNA can stimulate the production of an inhibitory component of a central signaling pathway to impair cartilage development.
[Mh] Termos MeSH primário: Cartilagem/embriologia
Cartilagem/enzimologia
MAP Quinase Quinase 1/metabolismo
Sistema de Sinalização das MAP Quinases
MicroRNAs/metabolismo
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Sítios de Ligação/genética
Sistemas CRISPR-Cas/genética
Condrócitos/metabolismo
Deleção de Genes
Regulação da Expressão Gênica no Desenvolvimento
Inativação Gênica
Lâmina de Crescimento/metabolismo
Hemizigoto
Homeostase
MAP Quinase Quinase 1/genética
Masculino
Camundongos Transgênicos
MicroRNAs/genética
Organogênese/genética
Estabilidade de RNA/genética
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
RNA Interferente Pequeno/metabolismo
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (MIRN322 microRNA, mouse); 0 (MicroRNAs); 0 (RNA, Messenger); 0 (RNA, Small Interfering); EC 2.7.12.2 (MAP Kinase Kinase 1); EC 2.7.12.2 (Map2k1 protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1242/dev.148429


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[PMID]:28767613
[Au] Autor:Kwon KS; Wang SI; Lee JH; Moon YJ; Kim JR
[Ad] Endereço:aDepartment of Preventive Medicine, Chonbuk National University Medical School bDepartment of Orthopaedic Surgery, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital and Research Institute for Endocrine Sciences, Jeonju, Republic of Korea.
[Ti] Título:Effect of greater trochanteric epiphysiodesis after femoral varus osteotomy for lateral pillar classification B and B/C border Legg-Calvé-Perthes disease: A retrospective observational study.
[So] Source:Medicine (Baltimore);96(31):e7723, 2017 Aug.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This is a retrospective observational study. Greater trochanteric epiphysiodesis (GTE) has been recommended to prevent Trendelenburg gait and limitation of the hip joint motion due to trochanteric overgrowth after femoral varus osteotomy (FVO) in Legg-Calvé-Perthes disease (LCPD). However, capital femoral physeal arrest frequently occurs in patients with severe disease (lateral pillar C), so GTE might not be as effective in these patients. The aim of this study was to compare trochanteric growth inhibition due to GTE after FVO between 2 age groups (<8 or >8 years) in patients with lateral pillar B and B/C border LCPD and evaluate the effectiveness of GTE compared with the normal, unaffected hip.This study included 19 children with lateral pillar B and B/C border LCPD in 1 leg who underwent FVO followed by GTE. Of the 19 children, 9 underwent GTE before the age of 8 years and 10 underwent GTE after 8 years of age. On radiographs taken at the immediate postoperative period and at skeletal maturity, the articulo-trochanteric distance (ATD), center-trochanteric distance (CTD), and neck-shaft angle (NSA) were compared between the 2 age groups. The amount of correction was compared between groups. The contralateral, unaffected hip was used as a control for trochanteric growth. The patients were clinically evaluated with Iowa hip score at the final follow-up.There was no significant difference between the 2 age groups in terms of time to GTE, length of follow-up, or lateral pillar classification. In the affected hip, the amount of correction of the ATD, CTD, and NSA was significantly greater in patients < 8 years than in patients > 8 years. However, in the unaffected hip, the change in the ATD, CTD, and NSA did not differ significantly between the 2 groups.We suggest that FVO followed by GTE for lateral pillar B and B/C border LCPD in patients under the age of 8 years can affect growth of the greater trochanter. However, effective growth inhibition due to GTE was not achieved after 8 years of age.
[Mh] Termos MeSH primário: Fêmur/crescimento & desenvolvimento
Fêmur/cirurgia
Lâmina de Crescimento/cirurgia
Doença de Legg-Calve-Perthes/cirurgia
Osteotomia
[Mh] Termos MeSH secundário: Fatores Etários
Criança
Fêmur/diagnóstico por imagem
Seguimentos
Lâmina de Crescimento/diagnóstico por imagem
Seres Humanos
Doença de Legg-Calve-Perthes/classificação
Doença de Legg-Calve-Perthes/diagnóstico por imagem
Masculino
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007723


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[PMID]:28675805
[Au] Autor:Lazarus S; Tseng HW; Lawrence F; Woodruff MA; Duncan EL; Pettit AR
[Ad] Endereço:Translational Research Institute, Brisbane, Queensland, Australia; University of Queensland Diamantina Institute, Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia; Department of Endocrinology and Diabetes, Royal Brisbane and Women's Hospital, Brisbane, Queensland, A
[Ti] Título:Characterization of Normal Murine Carpal Bone Development Prompts Re-Evaluation of Pathologic Osteolysis as the Cause of Human Carpal-Tarsal Osteolysis Disorders.
[So] Source:Am J Pathol;187(9):1923-1934, 2017 Sep.
[Is] ISSN:1525-2191
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multicentric carpal-tarsal osteolysis; multicentric osteolysis, nodulosis, and arthropathy; and Winchester syndromes, skeletal dysplasias characterized by carpal/tarsal and epiphyseal abnormalities, are caused by mutations in v-maf musculoaponeurotic fibrosarcoma oncogene ortholog B (MAFB), matrix metalloproteinase (MMP) 2, and MMP14, respectively; however, the underlying pathophysiology is unclear. Osteoclast-mediated osteolysis has been regarded as the main mechanism, but does not explain the skeletal distribution. We hypothesized that MAFB, MMP-2, and MMP-14 have integral roles in carpal/tarsal and epiphyseal bone development. Normal neonatal mouse forepaws were imaged by micro-computed tomography and examined histologically. Murine forepaw ossification occurred sequentially. Subarticular regions of endochondral ossification showed morphologic and calcification patterns that were distinct from archetypical physeal endochondral ossification. This suggests that two different forms of endochondral ossification occur. The skeletal sites showing the greatest abnormality in the carpal-tarsal osteolysis syndromes are regions of subarticular ossification. Thus, abnormal bone formation in areas of subarticular ossification may explain the site-specific distribution of the carpal-tarsal osteolysis phenotype. MafB, Mmp-2, and Mmp-14 were expressed widely, and tartrate-resistant acid phosphatase staining notably was absent in the subarticular regions of the cartilage anlagen and entheses at a time point most relevant to the human osteolysis syndromes. Thus, abnormal peri-articular skeletal development and modeling, rather than excessive bone resorption, may be the underlying pathophysiology of these skeletal syndromes.
[Mh] Termos MeSH primário: Ossos do Carpo/crescimento & desenvolvimento
Lâmina de Crescimento/patologia
Osteólise/patologia
[Mh] Termos MeSH secundário: Animais
Proteínas de Arabidopsis
Ossos do Carpo/diagnóstico por imagem
Ossos do Carpo/metabolismo
Pré-Escolar
Lâmina de Crescimento/diagnóstico por imagem
Lâmina de Crescimento/metabolismo
Seres Humanos
Liases Intramoleculares
Fator de Transcrição MafB/metabolismo
Metaloproteinase 14 da Matriz/metabolismo
Metaloproteinase 2 da Matriz/metabolismo
Camundongos
Osteogênese
Osteólise/diagnóstico por imagem
Osteólise/metabolismo
Microtomografia por Raio-X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Arabidopsis Proteins); 0 (MafB Transcription Factor); 0 (Mafb protein, mouse); EC 3.4.24.24 (Matrix Metalloproteinase 2); EC 3.4.24.80 (Matrix Metalloproteinase 14); EC 5.5.- (Intramolecular Lyases); EC 5.5.1.6 (CHIL protein, Arabidopsis)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170914
[Lr] Data última revisão:
170914
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170705
[St] Status:MEDLINE


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[PMID]:28587051
[Au] Autor:Giantsoudi D; Seco J; Eaton BR; Simeone FJ; Kooy H; Yock TI; Tarbell NJ; DeLaney TF; Adams J; Paganetti H; MacDonald SM
[Ad] Endereço:Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Electronic address: dgiantsoudi@mgh.harvard.edu.
[Ti] Título:Evaluating Intensity Modulated Proton Therapy Relative to Passive Scattering Proton Therapy for Increased Vertebral Column Sparing in Craniospinal Irradiation in Growing Pediatric Patients.
[So] Source:Int J Radiat Oncol Biol Phys;98(1):37-46, 2017 May 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: At present, proton craniospinal irradiation (CSI) for growing children is delivered to the whole vertebral body (WVB) to avoid asymmetric growth. We aimed to demonstrate the feasibility and potential clinical benefit of delivering vertebral body sparing (VBS) versus WVB CSI with passively scattered (PS) and intensity modulated proton therapy (IMPT) in growing children treated for medulloblastoma. METHODS AND MATERIALS: Five plans were generated for medulloblastoma patients, who had been previously treated with CSI PS proton radiation therapy: (1) single posteroanterior (PA) PS field covering the WVB (PS-PA-WVB); (2) single PA PS field that included only the thecal sac in the target volume (PS-PA-VBS); (3) single PA IMPT field covering the WVB (IMPT-PA-WVB); (4) single PA IMPT field, target volume including thecal sac only (IMPT-PA-VBS); and (5) 2 posterior-oblique (-35°, +35°) IMPT fields, with the target volume including the thecal sac only (IMPT2F-VBS). For all cases, 23.4 Gy (relative biologic effectiveness [RBE]) was prescribed to 95% of the spinal canal. The dose, linear energy transfer, and variable-RBE-weighted dose distributions were calculated for all plans using the tool for particle simulation, version 2, Monte Carlo system. RESULTS: IMPT VBS techniques efficiently spared the anterior vertebral bodies (AVBs), even when accounting for potential higher variable RBE predicted by linear energy transfer distributions. Assuming an RBE of 1.1, the V10 Gy(RBE) decreased from 100% for the WVB techniques to 59.5% to 76.8% for the cervical, 29.9% to 34.6% for the thoracic, and 20.6% to 25.1% for the lumbar AVBs, and the V20 Gy(RBE) decreased from 99.0% to 17.8% to 20.0% for the cervical, 7.2% to 7.6% for the thoracic, and 4.0% to 4.6% for the lumbar AVBs when IMPT VBS techniques were applied. The corresponding percentages for the PS VBS technique were higher. CONCLUSIONS: Advanced proton techniques can sufficiently reduce the dose to the vertebral body and allow for vertebral column growth for children with central nervous system tumors requiring CSI. This was true even when considering variable RBE values. A clinical trial is planned for VBS to the thoracic and lumbosacral spine in growing children.
[Mh] Termos MeSH primário: Neoplasias Cerebelares/radioterapia
Radiação Cranioespinal/métodos
Meduloblastoma/radioterapia
Tratamentos com Preservação do Órgão/métodos
Terapia com Prótons/métodos
Radioterapia de Intensidade Modulada/métodos
Espalhamento de Radiação
Coluna Vertebral/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Fatores Etários
Criança
Esôfago/diagnóstico por imagem
Estudos de Viabilidade
Lâmina de Crescimento
Seres Humanos
Intestino Delgado/diagnóstico por imagem
Rim/diagnóstico por imagem
Transferência Linear de Energia
Fígado/diagnóstico por imagem
Método de Monte Carlo
Órgãos em Risco/diagnóstico por imagem
Dosagem Radioterapêutica
Planejamento da Radioterapia Assistida por Computador/métodos
Eficiência Biológica Relativa
Coluna Vertebral/diagnóstico por imagem
Glândula Tireoide/diagnóstico por imagem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170721
[Lr] Data última revisão:
170721
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE



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