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Pesquisa : A02.835.232.570 [Categoria DeCS]
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  1 / 19 MEDLINE  
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[PMID]:28570671
[Au] Autor:Liebsch C; Graf N; Appelt K; Wilke HJ
[Ad] Endereço:Institute of Orthopaedic Research and Biomechanics, Trauma Research Centre Ulm, Ulm University, Ulm, Germany.
[Ti] Título:The rib cage stabilizes the human thoracic spine: An in vitro study using stepwise reduction of rib cage structures.
[So] Source:PLoS One;12(6):e0178733, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The stabilizing effect of the rib cage on the human thoracic spine is still not sufficiently analyzed. For a better understanding of this effect as well as the calibration and validation of numerical models of the thoracic spine, experimental biomechanics data is required. This study aimed to determine (1) the stabilizing effect of the single rib cage structures on the human thoracic spine as well as the effect of the rib cage on (2) the flexibility of the single motion segments and (3) coupled motion behavior of the thoracic spine. Six human thoracic spine specimens including the entire rib cage were loaded quasi-statically with pure moments of ± 2 Nm in flexion/extension (FE), lateral bending (LB), and axial rotation (AR) using a custom-built spine tester. Motion analysis was performed using an optical motion tracking system during load application to determine range of motion (ROM) and neutral zone (NZ). Specimens were tested (1) in intact condition, (2) after removal of the intercostal muscles, (3) after median sternotomy, after removal of (4) the anterior rib cage up to the rib stumps, (5) the right sixth to eighth rib head, and (6) all rib heads. Significant (p < 0.05) increases of the ROM were found after dissecting the intercostal muscles (LB: + 22.4%, AR: + 22.6%), the anterior part of the rib cage (FE: + 21.1%, LB: + 10.9%, AR: + 72.5%), and all rib heads (AR: + 5.8%) relative to its previous condition. Compared to the intact condition, ROM and NZ increased significantly after removing the anterior part of the rib cage (FE: + 52.2%, + 45.6%; LB: + 42.0%, + 54.0%; AR: + 94.4%, + 187.8%). Median sternotomy (FE: + 11.9%, AR: + 21.9%) and partial costovertebral release (AR: + 11.7%) significantly increased the ROM relative to its previous condition. Removing the entire rib cage increased both monosegmental and coupled motion ROM, but did not alter the qualitative motion behavior. The rib cage has a strong effect on thoracic spine rigidity, especially in axial rotation by a factor of more than two, and should therefore be considered in clinical scenarios, in vitro, and in silico.
[Mh] Termos MeSH primário: Caixa Torácica/fisiologia
Coluna Vertebral/fisiologia
Vértebras Torácicas/fisiologia
[Mh] Termos MeSH secundário: Idoso
Cadáver
Feminino
Seres Humanos
Técnicas In Vitro
Masculino
Meia-Idade
Amplitude de Movimento Articular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178733


  2 / 19 MEDLINE  
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[PMID]:28363375
[Au] Autor:Khullar OV; Fernandez FG
[Ad] Endereço:Section of General Thoracic Surgery, Emory University School of Medicine, 1365 Clifton Road, NE, Suite A2214, Atlanta, GA 30322, USA.
[Ti] Título:Prosthetic Reconstruction of the Chest Wall.
[So] Source:Thorac Surg Clin;27(2):201-208, 2017 May.
[Is] ISSN:1558-5069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Large chest wall resections can result in skeletal instability, altered respiratory mechanics, and significant cosmetic defects. Here the authors review a variety of prostheses that can be used to reconstruct these defects, the indications for their use, the technique for implantation, and the available data regarding their clinical outcomes.
[Mh] Termos MeSH primário: Próteses e Implantes
Procedimentos Cirúrgicos Reconstrutivos/métodos
Caixa Torácica/cirurgia
Telas Cirúrgicas
Procedimentos Cirúrgicos Torácicos/métodos
Parede Torácica/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Avaliação de Resultados (Cuidados de Saúde)
Procedimentos Cirúrgicos Reconstrutivos/instrumentação
Procedimentos Cirúrgicos Torácicos/instrumentação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


  3 / 19 MEDLINE  
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[PMID]:28363373
[Au] Autor:Thomas M; Shen KR
[Ad] Endereço:Division of Cardiothoracic Surgery, Mayo Clinic, 4500 San Pablo Road, Jacksonville, FL 32224, USA. Electronic address: Thomas.mathew@mayo.edu.
[Ti] Título:Primary Tumors of the Osseous Chest Wall and Their Management.
[So] Source:Thorac Surg Clin;27(2):181-193, 2017 May.
[Is] ISSN:1558-5069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Primary osseous tumors of the chest wall are uncommon neoplasms. They occur in a wide variety of pathologic forms, most of which can be distinguished by unique radiologic appearance. Management of these tumors depends on the diagnosis and stage. Adequate surgical resection is critical in achieving the best outcomes for most of these tumors. Chemotherapy and radiation may have an adjuvant role. Surgeons considering resection of any chest wall tumor should have a sound knowledge of the principles of resection and reconstruction.
[Mh] Termos MeSH primário: Neoplasias Ósseas/cirurgia
Procedimentos Cirúrgicos Reconstrutivos
Caixa Torácica/cirurgia
Neoplasias Torácicas/cirurgia
Procedimentos Cirúrgicos Torácicos
Parede Torácica/cirurgia
[Mh] Termos MeSH secundário: Cistos Ósseos Aneurismáticos/diagnóstico
Cistos Ósseos Aneurismáticos/cirurgia
Cistos Ósseos Aneurismáticos/terapia
Neoplasias Ósseas/diagnóstico
Neoplasias Ósseas/terapia
Quimiorradioterapia Adjuvante
Condroma/diagnóstico
Condroma/cirurgia
Condroma/terapia
Histiocitose de Células de Langerhans/diagnóstico
Histiocitose de Células de Langerhans/cirurgia
Histiocitose de Células de Langerhans/terapia
Seres Humanos
Osteocondrodisplasias/diagnóstico
Osteocondrodisplasias/cirurgia
Osteocondrodisplasias/terapia
Prognóstico
Sarcoma/diagnóstico
Sarcoma/cirurgia
Sarcoma/terapia
Neoplasias Torácicas/diagnóstico
Neoplasias Torácicas/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


  4 / 19 MEDLINE  
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[PMID]:28363372
[Au] Autor:Raz DJ; Clancy SL; Erhunmwunsee LJ
[Ad] Endereço:Division of Thoracic Surgery, City of Hope, MOB 2001B, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address: draz@coh.org.
[Ti] Título:Surgical Management of the Radiated Chest Wall and Its Complications.
[So] Source:Thorac Surg Clin;27(2):171-179, 2017 May.
[Is] ISSN:1558-5069
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Radiation to the chest wall is common before resection of tumors. Osteoradionecrosis can occur after radiation treatment. Radical resection and reconstruction can be lifesaving. Soft tissue coverage using myocutaneous or omental flaps is determined by the quality of soft tissue available and the status of the vascular pedicle supplying available myocutaneous flaps. Radiation-induced sarcomas of the chest wall occur most commonly after radiation therapy for breast cancer. Although angiosarcomas are the most common radiation-induced sarcomas, osteosarcoma, myosarcomas, rhabdomyosarcoma, and undifferentiated sarcomas also occur. The most effective treatment is surgical resection. Inoperable tumors are treated with chemotherapy, with low response rates.
[Mh] Termos MeSH primário: Neoplasias da Mama/radioterapia
Neoplasias Induzidas por Radiação/cirurgia
Osteorradionecrose/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Sarcoma/cirurgia
Procedimentos Cirúrgicos Torácicos/métodos
Parede Torácica/cirurgia
[Mh] Termos MeSH secundário: Neoplasias Ósseas/etiologia
Neoplasias Ósseas/cirurgia
Feminino
Seres Humanos
Meia-Idade
Estadiamento de Neoplasias
Neoplasias Induzidas por Radiação/etiologia
Osteorradionecrose/etiologia
Prognóstico
Radioterapia/efeitos adversos
Caixa Torácica/cirurgia
Sarcoma/etiologia
Neoplasias de Tecidos Moles/etiologia
Neoplasias de Tecidos Moles/cirurgia
Retalhos Cirúrgicos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170522
[Lr] Data última revisão:
170522
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170402
[St] Status:MEDLINE


  5 / 19 MEDLINE  
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[PMID]:28276642
[Au] Autor:Liu Z; Hu ZS; Qiu Y; Zhang Z; Zhao ZH; Han X; Zhu ZZ
[Ad] Endereço:The Department of Spine Surgery, Drum Tower Hospital of Nanjing University Medical School, Nanjing, China.
[Ti] Título:Role of Clavicle Chest Cage Angle Difference in Predicting Postoperative Shoulder Balance in Lenke 5C Adolescent Idiopathic Scoliosis Patients after Selective Posterior Fusion.
[So] Source:Orthop Surg;9(1):86-90, 2017 Feb.
[Is] ISSN:1757-7861
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the role of preoperative clavicle chest cage angle difference (CCAD) on postoperative radiographic shoulder imbalance, patient's satisfaction and surgeon's fulfillment in Lenke 5 adolescent idiopathic scoliosis (AIS). CCAD, as a novel radiographic parameter, has proven to be a reliable predictor for postoperative shoulder imbalance in Lenke 1 AIS patients. However, the value of CCAD in predicting shoulder balance has never been evaluated in Lenke 5 AIS patients. METHODS: A total of 42 Lenke 5C AIS patients aged from 10 to 18 years old with a minimum 2-year follow-up were enrolled for evaluation. All patients underwent selective posterior spinal instrumentation and fusion using the all segmental pedicle screw technique by the same surgical team. The fusion levels were determined according to the Lenke criteria. Shoulder height difference (SHD) and CCAD were measured on anteroposterior (AP) standing radiographs. The patients' satisfaction and the surgeons' fulfillment were evaluated using a questionnaire. A receiver operative characteristic curve analysis was performed to explore the threshold values of preoperative CCAD in the prediction of the final follow-up radiographic shoulder imbalance, patients' satisfaction and surgeons' fulfillment. RESULTS: The average preoperative Cobb angle of the main curve was 46.8° ± 4.8°, and the average immediate postoperative Cobb angle was 13.3° ± 2.6°, representing an average surgical correction rate of 75.6% ± 8.5%. The average follow-up time was 29.2 months. At the last follow-up, the value of preoperative CCAD was significantly higher in patients with unbalanced shoulders (SHD ≥ 10 mm). At the final follow-up, 66.7% (28/42) of the patients were satisfied with their appearance, while 33.3% (14/42) of the patients were not satisfied with their appearance. At the final follow-up, 61.9% (26/42) of the surgeons were fulfilled with their operation, while 38.1% (16/42) of the surgeons were not. For patients' satisfaction and surgeons' fulfillment, the preoperative CCAD was significantly greater in patients with unsatisfied outcomes. DISCUSSION: Clavicle chest cage angle difference could be a reliable predictor for evaluating postoperative shoulder imbalance in AIS patients undergoing selective posterior fusion for Lenke 5C curves. A greater preoperative CCAD was significantly correlated with a postoperative radiographic imbalance of shoulders and dissatisfaction, which will guide spine surgeons in their preoperative planning and in the surgical management of AIS to reduce postoperative shoulder imbalance.
[Mh] Termos MeSH primário: Clavícula/diagnóstico por imagem
Caixa Torácica/diagnóstico por imagem
Escoliose/cirurgia
Ombro/patologia
Fusão Vertebral/métodos
[Mh] Termos MeSH secundário: Adolescente
Parafusos Ósseos
Criança
Clavícula/patologia
Estética
Feminino
Seguimentos
Seres Humanos
Masculino
Satisfação do Paciente
Cuidados Pré-Operatórios/métodos
Prognóstico
Radiografia
Caixa Torácica/patologia
Escoliose/diagnóstico por imagem
Ombro/diagnóstico por imagem
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE
[do] DOI:10.1111/os.12305


  6 / 19 MEDLINE  
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[PMID]:28196648
[Au] Autor:Yotsueda R; Taniguchi M; Tanaka S; Eriguchi M; Fujisaki K; Torisu K; Masutani K; Hirakata H; Kitazono T; Tsuruya K
[Ad] Endereço:Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
[Ti] Título:Cardiothoracic Ratio and All-Cause Mortality and Cardiovascular Disease Events in Hemodialysis Patients: The Q-Cohort Study.
[So] Source:Am J Kidney Dis;70(1):84-92, 2017 Jul.
[Is] ISSN:1523-6838
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cardiothoracic ratio by chest radiography is commonly used to assess volume status. Little is known about the relationships between cardiothoracic ratio and the incidence of clinical outcomes in patients undergoing hemodialysis (HD). STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: 3,436 participants in the Q-Cohort Study 18 years or older who underwent maintenance HD in Japan. PREDICTOR: Cardiothoracic ratio. OUTCOMES & MEASUREMENTS: All-cause mortality and cardiovascular disease (CVD) events. RESULTS: During a 4-year follow-up period, 564 (16.4%) patients died of any cause and 590 (17.2%) developed CVD events. From baseline cardiothoracic ratios, participants were categorized into sex-specific quartiles because cardiothoracic ratio distribution differed by sex. The 4-year event-free survival rate, in terms of all-cause mortality and CVD events, was significantly lower with higher cardiothoracic ratios. Compared to the lowest cardiothoracic ratio (quartile 1), multivariable-adjusted HRs for all-cause mortality were 0.89 (95% CI, 0.66-1.20), 1.41 (1.08-1.86), and 1.52 (1.17-2.00) in patients from quartiles 2, 3, and 4, respectively. Similarly, in comparison to quartile 1, multivariable-adjusted HRs for CVD events were 1.00 (95% CI, 0.77-1.31), 1.18 (0.92-1.53), and 1.37 (1.07-1.76) in patients from quartiles 2, 3, and 4, respectively. Furthermore, the combination of higher cardiothoracic ratio and normohypotension (systolic blood pressure < 140mmHg and diastolic blood pressure < 90mmHg) was associated with higher risk for CVD events. LIMITATIONS: Single measurement of all variables, potentially less-heterogeneous patient population, and limited ascertainment of cardiac parameters and the outcomes. CONCLUSIONS: Higher cardiothoracic ratio is associated with higher risk for both all-cause mortality and CVD events in patients undergoing HD.
[Mh] Termos MeSH primário: Doenças Cardiovasculares/epidemiologia
Coração/anatomia & histologia
Diálise Renal/mortalidade
Caixa Torácica/anatomia & histologia
[Mh] Termos MeSH secundário: Idoso
Doenças Cardiovasculares/etiologia
Causas de Morte
Estudos de Coortes
Feminino
Coração/diagnóstico por imagem
Seres Humanos
Japão
Estudos Longitudinais
Masculino
Meia-Idade
Tamanho do Órgão
Estudos Prospectivos
Radiografia Torácica
Diálise Renal/efeitos adversos
Caixa Torácica/diagnóstico por imagem
Medição de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE


  7 / 19 MEDLINE  
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[PMID]:27260566
[Au] Autor:Shaw G; Lessley D; Ash J; Poplin J; McMurry T; Sochor M; Crandall J
[Ad] Endereço:a University of Virginia , Center for Applied Biomechanics , Charlottesville , Virginia.
[Ti] Título:Small female rib cage fracture in frontal sled tests.
[So] Source:Traffic Inj Prev;18(1):77-82, 2017 Jan 02.
[Is] ISSN:1538-957X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The 2 objectives of this study are to (1) examine the rib and sternal fractures sustained by small stature elderly females in simulated frontal crashes and (2) determine how the findings are characterized by prior knowledge and field data. METHODS: A test series was conducted to evaluate the response of 5 elderly (average age 76 years) female postmortem human subjects (PMHS), similar in mass and size to a 5th percentile female, in 30 km/h frontal sled tests. The subjects were restrained on a rigid planar seat by bilateral rigid knee bolsters, pelvic blocks, and a custom force-limited 3-point shoulder and lap belt. Posttest subject injury assessment included identifying rib cage fractures by means of a radiologist read of a posttest computed tomography (CT) and an autopsy. The data from a motion capture camera system were processed to provide chest deflection, defined as the movement of the sternum relative to the spine at the level of T8. A complementary field data investigation involved querying the NASS-CDS database over the years 1997-2012. The targeted cases involved belted front seat small female passenger vehicle occupants over 40 years old who were injured in 25 to 35 km/h delta-V frontal crashes (11 to 1 o'clock). RESULTS: Peak upper shoulder belt tension averaged 1,970 N (SD = 140 N) in the sled tests. For all subjects, the peak x-axis deflection was recorded at the sternum with an average of -44.5 mm or 25% of chest depth. The thoracic injury severity based on the number and distribution of rib fractures yielded 4 subjects coded as Abbreviated Injury Scale (AIS) 3 (serious) and one as AIS 5 (critical). The NASS-CDS field data investigation of small females identified 205 occupants who met the search criteria. Rib fractures were reported for 2.7% of the female occupants. CONCLUSIONS: The small elderly test subjects sustained a higher number of rib cage fractures than expected in what was intended to be a minimally injurious frontal crash test condition. Neither field studies nor prior laboratory frontal sled tests conducted with 50th percentile male PMHS predicted the injury severity observed. Although this was a limited study, the results justify further exploration of the risk of rib cage injury for small elderly female occupants.
[Mh] Termos MeSH primário: Acidentes de Trânsito
Fraturas Ósseas/etiologia
Caixa Torácica/lesões
Esterno/lesões
[Mh] Termos MeSH secundário: Escala Resumida de Ferimentos
Idoso
Idoso de 80 Anos ou mais
Fenômenos Biomecânicos
Cadáver
Bases de Dados Factuais
Feminino
Fraturas Ósseas/diagnóstico por imagem
Fraturas Ósseas/fisiopatologia
Seres Humanos
Meia-Idade
Fraturas por Osteoporose/diagnóstico por imagem
Fraturas por Osteoporose/etiologia
Fraturas por Osteoporose/fisiopatologia
Caixa Torácica/diagnóstico por imagem
Fraturas das Costelas/diagnóstico por imagem
Fraturas das Costelas/etiologia
Fraturas das Costelas/fisiopatologia
Cintos de Segurança
Esterno/diagnóstico por imagem
Esterno/fisiopatologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160605
[St] Status:MEDLINE


  8 / 19 MEDLINE  
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[PMID]:28139600
[Au] Autor:Kurkov AV; Shekhter AB; Guller AE; Plyakin VA; Paukov VS
[Ad] Endereço:Institute for Regenerative Medicine, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation, Moscow, Russia; Acad. A.I. Strukov Department of Pathological Anatomy, I.M. Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federa
[Ti] Título:[The morphological and morphometric study of amianthoid transformation of the costal cartilage in health and in keeled chest deformity in children].
[Ti] Título:Morfologicheskoe i morfometricheskoe issledovanie amiantoidnoi transformatsii rebernykh khryashchei v norme i pri kilevidnoi deformatsii grudnoi kletki u detei..
[So] Source:Arkh Patol;78(6):30-37, 2016.
[Is] ISSN:0004-1955
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Amianthoid transformation (AT) is the accumulations of abnormal collagen structures (amianthoid fibers) in the hyaline cartilages, tumors, and tendons. Neither functional value of costal cartilage matrix AT, nor its role in the pathogenesis of congenital chest deformities is known now. AIM: to examine the morphological features of AT in the costal cartilage of children with the normal and keeled chest. SUBJECTS AND METHODS: Costal cartilages were studied in 6 children with the normal chest (autopsy material) and in 5 ones with keeled chest (surgical material). Tissue fragments were fixed in 10% neutral formalin and embedded in compacted paraffin. The sections were stained with hematoxylin and eosin, picrofuchsin by van Gieson, with picrosirius, toluidine blue and by the Malaurie method modified by Gallego. The specimens were examined by light, phase-contrast, dark-field, fluorescence, and polarization microscopy. The frequency of AT sites and their area were morphometrically studied and the findings were then statistically processed. RESULTS: Various types of AT in the costal cartilages were described as both the normal and keeled chest. According to their morphological features, classic, fine-fiber, twisted, and intralacunar types were identified. There were statistically significant increases in the incidence of all types (except the intralacunar one) and in the area of the fine-fiber AT type in keeled chest deformity as compared to health. There were positive correlations between the area of classic, intralacunar, and twisted types in both groups and between the area of a classic type and age in the controls. CONCLUSION: A classification of AT areas varying in structures in health and disease has been given for the first time; their relation to each other and to the presence of keeled deformity shown, which, in our opinion, suggests that AT is implicated in the pathogenesis of the disease.
[Mh] Termos MeSH primário: Cartilagem Costal/patologia
Anormalidades Musculoesqueléticas/patologia
Caixa Torácica/patologia
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Cartilagem Costal/anormalidades
Feminino
Seres Humanos
Masculino
Caixa Torácica/anormalidades
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170201
[St] Status:MEDLINE
[do] DOI:10.17116/patol201678630-37


  9 / 19 MEDLINE  
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[PMID]:28133215
[Au] Autor:Koh T; Sakai T; Kato S; Hirajima S; Nishio M; Soga K; Oguro A; Nakagawa N
[Ad] Endereço:Dept. of Surgery, Japan Community Health care Organization Kobe Central Hospital.
[Ti] Título:[Long-Term Survival of a Patient with Stage IV Breast Cancer and An Intrathoracic Space-Occupying Metastatic Lesion].
[So] Source:Gan To Kagaku Ryoho;43(12):2041-2043, 2016 Nov.
[Is] ISSN:0385-0684
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 50-year old woman noticed left axillary lymph node swelling and presented at our hospital. CNB showed adenocarcinoma( pap-tub, ER+, PgR+, HER2 3+). CT revealed a right lung metastatic nodule and swollen lymph nodes above the left collarbone and left axilla. However, no breast tumor was found at that time. We diagnosed occult breast cancer, TxN3bM1 (lung), Stage IV . FEC(100), paclitaxel, letrozole, anastrozole, exemestane plus trastuzumab, tegafur/uracil plus trastuzumab, and lapatinib plus capecitabine were sequentially administered. Five years and 9 months after the treatment started, CT revealed a right intrathoracic lesion that had gradually increased in size. Subsequently, trastuzumab plus pertuzumab plus docetaxel, bevacizumab plus paclitaxel, trastuzumab emtansine, trastuzumab plus fulvestrant, and doxifluridine plus medroxyprogesterone acetate plus cyclophosphamide(DMpC therapy)were sequentially administered. At this time, 8 years after the treatment started, trastuzumab plus pertuzumab plus vinorelbine were also administered. An intrathoracic space-occupying lesion due to breast cancer is rare, and anti-HER2 chemotherapy was effective for this patient.
[Mh] Termos MeSH primário: Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias da Mama/tratamento farmacológico
Neoplasias da Mama/patologia
Caixa Torácica/patologia
[Mh] Termos MeSH secundário: Neoplasias da Mama/diagnóstico
Feminino
Seres Humanos
Metástase Linfática
Meia-Idade
Estadiamento de Neoplasias
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170131
[St] Status:MEDLINE


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[PMID]:27723598
[Au] Autor:Islam N; Misra S
[Ti] Título:"Catch the Pendulum": The Problem of Asymmetric Data Delivery in Electromagnetic Nanonetworks.
[So] Source:IEEE Trans Nanobioscience;15(6):576-584, 2016 Sep.
[Is] ISSN:1558-2639
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The network of novel nano-material based nanodevices, known as nanoscale communication networks or nanonetworks has ushered a new communication paradigm in the terahertz band (0.1-10 THz). In this work, first we envisage an architecture of nanonetworks-based Coronary Heart Disease (CHD) monitoring, consisting of nano-macro interface (NM) and nanodevice-embedded Drug Eluting Stents (DESs), termed as nanoDESs. Next, we study the problem of asymmetric data delivery in such nanonetworks-based systems and propose a simple distance-aware power allocation algorithm, named catch-the-pendulum, which optimizes the energy consumption of nanoDESs for communicating data from the underlying nanonetworks to radio frequency (RF) based macro-scale communication networks. The algorithm exploits the periodic change in mean distance between a nanoDES, inserted inside the affected coronary artery, and the NM, fitted in the intercostal space of the rib cage of a patient suffering from a CHD. Extensive simulations confirm superior performance of the proposed algorithm with respect to energy consumption, packet delivery, and shutdown phase.
[Mh] Termos MeSH primário: Algoritmos
Simulação por Computador
Monitorização Fisiológica/métodos
Nanotecnologia/métodos
[Mh] Termos MeSH secundário: Doença das Coronárias/fisiopatologia
Fenômenos Eletromagnéticos
Coração/fisiologia
Seres Humanos
Modelos Cardiovasculares
Caixa Torácica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE



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