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  1 / 13013 MEDLINE  
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[PMID]:27771363
[Au] Autor:Decker RS
[Ad] Endereço:Translational Research Program in Pediatric Orthopaedics, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, PA 19104, United States. Electronic address: RDecker@gnf.org.
[Ti] Título:Articular cartilage and joint development from embryogenesis to adulthood.
[So] Source:Semin Cell Dev Biol;62:50-56, 2017 02.
[Is] ISSN:1096-3634
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Within each synovial joint, the articular cartilage is uniquely adapted to bear dynamic compressive loads and shear forces throughout the joint's range of motion. Injury and age-related degeneration of the articular cartilage often lead to significant pain and disability, as the intrinsic repair capability of the tissue is extremely limited. Current surgical and biological treatment options have been unable to restore cartilage de novo. Before successful clinical cartilage restoration strategies can be developed, a better understanding of how the cartilage forms during normal development is essential. This review focuses on recent progress made towards addressing key questions about articular cartilage morphogenesis, including the origin of synovial joint progenitor cells, postnatal development and growth of the tissue. These advances have provided novel insight into fundamental questions about the developmental biology of articular cartilage, as well as potential cell sources that may participate in joint response to injury.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Cartilagem Articular/embriologia
Desenvolvimento Embrionário
Articulações/embriologia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Morfogênese
Células-Tronco/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  2 / 13013 MEDLINE  
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[PMID]:29324862
[Au] Autor:Chauvigné LAS; Belyk M; Brown S
[Ad] Endereço:Department of Psychology, Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada.
[Ti] Título:Taking two to tango: fMRI analysis of improvised joint action with physical contact.
[So] Source:PLoS One;13(1):e0191098, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Many forms of joint action involve physical coupling between the participants, such as when moving a sofa together or dancing a tango. We report the results of a novel two-person functional MRI study in which trained couple dancers engaged in bimanual contact with an experimenter standing next to the bore of the magnet, and in which the two alternated between being the leader and the follower of joint improvised movements. Leading showed a general pattern of self-orientation, being associated with brain areas involved in motor planning, navigation, sequencing, action monitoring, and error correction. In contrast, following showed a far more sensory, externally-oriented pattern, revealing areas involved in somatosensation, proprioception, motion tracking, social cognition, and outcome monitoring. We also had participants perform a "mutual" condition in which the movement patterns were pre-learned and the roles were symmetric, thereby minimizing any tendency toward either leading or following. The mutual condition showed greater activity in brain areas involved in mentalizing and social reward than did leading or following. Finally, the analysis of improvisation revealed the dual importance of motor-planning and working-memory areas. We discuss these results in terms of theories of both joint action and improvisation.
[Mh] Termos MeSH primário: Dança
Articulações/fisiologia
Imagem por Ressonância Magnética/métodos
Movimento
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180112
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191098


  3 / 13013 MEDLINE  
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[PMID]:29191466
[Au] Autor:Morgenstern C; Cabric S; Perka C; Trampuz A; Renz N
[Ad] Endereço:Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Center for Musculoskeletal Surgery (CMSC), Berlin, Germany.
[Ti] Título:Synovial fluid multiplex PCR is superior to culture for detection of low-virulent pathogens causing periprosthetic joint infection.
[So] Source:Diagn Microbiol Infect Dis;90(2):115-119, 2018 Feb.
[Is] ISSN:1879-0070
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Analysis of joint aspirate is the standard preoperative investigation for diagnosis of periprosthetic joint infection (PJI). We compared the diagnostic performance of culture and multiplex polymerase chain reaction (PCR) of synovial fluid for diagnosis of PJI. PATIENTS AND METHODS: Patients in whom aspiration of the prosthetic hip or knee joint was performed before revision arthroplasty were prospectively included. The performance of synovial fluid culture and multiplex PCR was compared by McNemar's chi-squared test. RESULTS: A total of 142 patients were included, 82 with knee and 60 with hip prosthesis. PJI was diagnosed in 77 patients (54%) and aseptic failure in 65 patients (46%). The sensitivity of synovial fluid culture and PCR was 52% and 60%, respectively, showing concordant results in 116 patients (82%). In patients with PJI, PCR missed 6 high-virulent pathogens (S. aureus, streptococci, E. faecalis, E. coli) which grew in synovial fluid culture, whereas synovial fluid culture missed 12 pathogens detected by multiplex PCR, predominantly low-virulent pathogens (Cutibacterium acnes and coagulase-negative staphylococci). In patients with aseptic failure, PCR detected 6 low-virulent organisms (predominantly C. acnes). CONCLUSION: While the overall performance of synovial fluid PCR was comparable to culture, PCR was superior for detection of low-virulent bacteria such as Cutibacterium spp. and coagulase-negative staphylococci. In addition, synovial fluid culture required several days for growth, whereas multiplex PCR provided results within 5hours in an automated manner.
[Mh] Termos MeSH primário: Articulações/microbiologia
Tipagem Molecular/métodos
Reação em Cadeia da Polimerase Multiplex/métodos
Infecções Relacionadas à Prótese/microbiologia
Líquido Sinovial/microbiologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Artroplastia de Quadril/efeitos adversos
Artroplastia do Joelho/efeitos adversos
Técnicas Bacteriológicas
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Infecções Relacionadas à Prótese/diagnóstico
Infecções Estafilocócicas/diagnóstico
Infecções Estafilocócicas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


  4 / 13013 MEDLINE  
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[PMID]:29287105
[Au] Autor:Labens R; Daniel C; Hall S; Xia XR; Schwarz T
[Ad] Endereço:School of Animal and Veterinary Sciences, Faculty of Science, Charles Sturt University, Wagga Wagga, New South Wales, Australia.
[Ti] Título:Effect of intra-articular administration of superparamagnetic iron oxide nanoparticles (SPIONs) for MRI assessment of the cartilage barrier in a large animal model.
[So] Source:PLoS One;12(12):e0190216, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Early diagnosis of cartilage disease at a time when changes are limited to depletion of extracellular matrix components represents an important diagnostic target to reduce patient morbidity. This report is to present proof of concept for nanoparticle dependent cartilage barrier imaging in a large animal model including the use of clinical magnetic resonance imaging (MRI). Conditioned (following matrix depletion) and unconditioned porcine metacarpophalangeal cartilage was evaluated on the basis of fluorophore conjugated 30 nm and 80 nm spherical gold nanoparticle permeation and multiphoton laser scanning and bright field microscopy after autometallographic particle enhancement. Consequently, conditioned and unconditioned joints underwent MRI pre- and post-injection with 12 nm superparamagnetic iron oxide nanoparticles (SPIONs) to evaluate particle permeation in the context of matrix depletion and use of a clinical 1.5 Tesla MRI scanner. To gauge the potential pro-inflammatory effect of intra-articular nanoparticle delivery co-cultures of equine synovium and cartilage tissue were exposed to an escalating dose of SPIONs and IL-6, IL-10, IFN-γ and PGE2 were assessed in culture media. The chemotactic potential of growth media samples was subsequently assessed in transwell migration assays on isolated equine neutrophils. Results demonstrate an increase in MRI signal following conditioning of porcine joints which suggests that nanoparticle dependent compositional cartilage imaging is feasible. Tissue culture and neutrophil migration assays highlight a dose dependent inflammatory response following SPION exposure which at the imaging dose investigated was not different from controls. The preliminary safety and imaging data support the continued investigation of nanoparticle dependent compositional cartilage imaging. To our knowledge, this is the first report in using SPIONs as intra-articular MRI contrast agent for studying cartilage barrier function, which could potentially lead to a new diagnostic technique for early detection of cartilage disease.
[Mh] Termos MeSH primário: Cartilagem Articular/diagnóstico por imagem
Articulações
Imagem por Ressonância Magnética/métodos
Nanopartículas de Magnetita/administração & dosagem
Modelos Animais
[Mh] Termos MeSH secundário: Animais
Biomarcadores/metabolismo
Cartilagem Articular/metabolismo
Quimiotaxia de Leucócito
Técnicas de Cocultura
Vias de Administração de Medicamentos
Feminino
Corantes Fluorescentes
Cavalos
Masculino
Microscopia Confocal
Neutrófilos/citologia
Suínos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Fluorescent Dyes); 0 (Magnetite Nanoparticles)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171230
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190216


  5 / 13013 MEDLINE  
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[PMID]:28460181
[Au] Autor:Jung GS; Buehler MJ
[Ad] Endereço:Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139; email: mbuehler@MIT.edu.
[Ti] Título:Multiscale Modeling of Muscular-Skeletal Systems.
[So] Source:Annu Rev Biomed Eng;19:435-457, 2017 Jun 21.
[Is] ISSN:1545-4274
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multiscale modeling of muscular-skeletal systems-the materials and structures that help organisms support themselves and move-is a rapidly growing field of study that has contributed key elements to the understanding of these systems, especially from a multiscale perspective. The systems, including materials such as bone and muscle, have hierarchical structures ranging from the nano- to the macroscale, and it is difficult to understand their macroscopic behaviors, both physiological and pathological, without knowledge of their hierarchical structures and properties. In this review, we discuss the methods of multiscale modeling. Through a series of case studies about key materials in muscular-skeletal systems, we describe how different methods can bridge the gap between hierarchical structures and their roles in the systems' mechanical properties. In particular, we emphasize the importance of the quality of minerals in bone. Finally, we discuss biomimetic material designs facilitated by additive manufacturing technology.
[Mh] Termos MeSH primário: Osso e Ossos/fisiologia
Articulações/fisiologia
Modelos Biológicos
Proteínas Motores Moleculares/fisiologia
Contração Muscular/fisiologia
Músculo Esquelético/fisiologia
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Seres Humanos
Estresse Mecânico
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Molecular Motor Proteins)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE
[do] DOI:10.1146/annurev-bioeng-071516-044555


  6 / 13013 MEDLINE  
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[PMID]:29238016
[Au] Autor:Kikuta J; Ishii M
[Ad] Endereço:Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University.
[Ti] Título:[Imaging of bone and joint destruction].
[So] Source:Nihon Rinsho Meneki Gakkai Kaishi;40(5):344-351, 2017.
[Is] ISSN:1349-7413
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:  Osteoclasts are bone-resorbing giant polykaryons that differentiate from mononuclear macrophage/monocyte-lineage hematopoietic precursors. We have originally established an advanced imaging system for visualizing in vivo behavior of osteoclasts and their precursors with intravital two-photon microscopy. By means of the system, we found that sphingosine-1-phosphate, a lipid mediator enriched in blood, controlled the migratory behavior of osteoclast precursors. We also developed pH-sensing chemical fluorescent probes to detect localized acidification by bone-resorbing osteoclasts on the bone surface in vivo, and identified two distinct functional states of differentiated osteoclasts, 'bone-resorptive' and 'non-resorptive'. In this review, we summarize our recent studies on the dynamics and functions of osteoclasts. Our intravital imaging techniques would be beneficial for studying the cellular dynamics in arthritic inflammation and bone destruction in vivo and would thus be useful for evaluating novel therapies targeting aspects of osteoclast dynamics in patients with bone-destructive diseases.
[Mh] Termos MeSH primário: Artropatias/diagnóstico por imagem
Artropatias/patologia
Articulações/citologia
Articulações/diagnóstico por imagem
Imagem Molecular/métodos
Osteoclastos/citologia
Osteoclastos/patologia
[Mh] Termos MeSH secundário: Animais
Osso e Ossos/citologia
Diferenciação Celular
Corantes Fluorescentes
Microscopia de Fluorescência por Excitação Multifotônica
Osteoclastos/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Fluorescent Dyes)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.2177/jsci.40.344


  7 / 13013 MEDLINE  
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[PMID]:29069018
[Au] Autor:Emamifar A; Hangaard J; Jensen Hansen IM
[Ad] Endereço:aDepartment of Rheumatology, Odense University Hospital, Svendborg Hospital, Svendborg bFaculty of Health Sciences, University of Southern Denmark, Odense cDepartment of Endocrinology, Odense University Hospital, Svendborg Hospital, Svendborg dDANBIO Registry, Copenhagen, Denmark.
[Ti] Título:Thyroid disorders in patients with newly diagnosed rheumatoid arthritis is associated with poor initial treatment response evaluated by disease activity score in 28 joints-C-reactive protein (DAS28-CRP): An observational cohort study.
[So] Source:Medicine (Baltimore);96(43):e8357, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:To determine the prevalence of thyroid disorders among newly diagnosed rheumatoid arthritis (RA) patients and evaluate the association between clinical characteristics of RA and thyroid disorders, and also initial treatment response in the RA patients with thyroid disorders.Newly diagnosed, adult RA patients who were diagnosed according to the new 2010 American College of Rheumatology/European League Against Rheumatism criteria since January 1, 2010, were included. Patients' demographic data, serology results including immunoglobulin M rheumatoid factor (IgM RF), anticyclic citrullinated peptide antibody (anti-CCP), and antinuclear antibody (ANA), and also disease activity score in 28 joints-C-reactive protein at the time of diagnosis and after 4 months (±1-2 months) of treatment initiation were extracted from Danish Danbio Registry. Patients' electronic hospital records for the past 10 years were reviewed to reveal if they had been diagnosed with thyroid disorders or they had abnormal thyroid test.In all, 439 patients were included, female 60.1%, mean age 64.6 ±â€Š15.0 years and disease duration 2.6 ±â€Š1.7 years. Prevalence of thyroid disorders was 69/439 (15.7%) and hypothyroidism was the most frequent disorder (30.4%). The presence of thyroid disorders among RA patients was significantly associated with female sex (P < .001), ANA positivity (P = .04), and anti-CCP ≥100 EU/mL (P = .05). Furthermore, RA patients with thyroid disorders had significantly poorer initial response to RA treatment compared with patients with isolated RA after 4 months of treatment (P = .02). There were no associations between thyroid disorders and age, disease duration, and also IgM RF positivity.Presence of thyroid disorders in RA patients is suggestive of a more aggressive disease and poor outcome, with direct effect on initial treatment response. To diagnose concurrent thyroid disorders at an earlier stage, routine measurement of serum thyroid-stimulating hormone is recommended in all RA patients at the time of diagnosis and with yearly interval thereafter.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Artrite Reumatoide/complicações
Proteína C-Reativa/análise
Índice de Gravidade de Doença
Doenças da Glândula Tireoide/sangue
[Mh] Termos MeSH secundário: Idoso
Anticorpos Antinucleares/sangue
Artrite Reumatoide/sangue
Artrite Reumatoide/tratamento farmacológico
Autoanticorpos/sangue
Estudos de Coortes
Dinamarca
Feminino
Seres Humanos
Imunoglobulina M/sangue
Articulações/patologia
Masculino
Meia-Idade
Peptídeos Cíclicos/imunologia
Prevalência
Sistema de Registros
Fator Reumatoide/sangue
Doenças da Glândula Tireoide/complicações
Doenças da Glândula Tireoide/epidemiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Antibodies, Antinuclear); 0 (Antirheumatic Agents); 0 (Autoantibodies); 0 (Immunoglobulin M); 0 (Peptides, Cyclic); 0 (cyclic citrullinated peptide); 9007-41-4 (C-Reactive Protein); 9009-79-4 (Rheumatoid Factor)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008357


  8 / 13013 MEDLINE  
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[PMID]:28957555
[Au] Autor:Tao Y; Wang Z; Wang L; Shi J; Guo X; Zhou W; Wu X; Liu Y; Zhang W; Yang H; Shi Q; Xu Y; Geng D
[Ad] Endereço:Department of Orthopedics, First Affiliated Hospital of Soochow University, Suzhou.
[Ti] Título:Downregulation of miR-106b attenuates inflammatory responses and joint damage in collagen-induced arthritis.
[So] Source:Rheumatology (Oxford);56(10):1804-1813, 2017 Oct 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective: miRNAs are small, signal-strand, non-coding RNAs that function in post-transcriptional regulation. We analysed the in vivo effect of miR-106b (miR-106b-5p) on inflammatory bone loss in CIA mice. Methods: CIA mice are developed by injecting DAB/1 mice with bovine type II collagen containing Freund's adjuvant and then the in vivo effect of miR-106b is examined. On day 22, mice were given lentiviral negative control, lentiviral-mediated miR-106b mimics or lentiviral-mediated miR-106b inhibitor via orbital injection on a weekly basis. Morphological changes in the ankle joints were assessed via micro-CT and histopathology and cytokine expression levels were examined via immunohistochemical staining, ELISA or flow cytometric analysis. miR-106b and osteoclastic-related gene expression was evaluated via quantitative real-time PCR. Results: CIA mice were found to have increased miR-106b expression and CIA-associated bone loss and inflammatory infiltration. miR-106b inhibitor treatment markedly decreased arthritis incidence and attenuated bone destruction and histological severity compared with the control group. Moreover, miR-106b inhibitor treatment suppressed RANK ligand (RANKL) expression, increased osteoprotegerin (OPG) expression and reduced the RANKL:OPG ratio in CIA mice. miR-106b inhibition also significantly decreased inflammatory mediator production in joint sections and reduced serum pro-inflammatory cytokine levels when compared with the control group. Additionally, miR-106b inhibition decreased tartrate-resistant acid phosphatase-positive cell numbers and suppressed murine bone marrow macrophage differentiation. Conclusion: These findings indicate that miR-106b inhibition can ameliorate CIA-associated inflammation and bone destruction and thus may serve as a potential therapeutic for human RA treatment.
[Mh] Termos MeSH primário: Artrite Experimental/genética
Osso e Ossos/patologia
Regulação para Baixo
Articulações/patologia
MicroRNAs/metabolismo
[Mh] Termos MeSH secundário: Animais
Artrite Experimental/induzido quimicamente
Artrite Experimental/tratamento farmacológico
Osso e Ossos/metabolismo
Colágeno Tipo II
Citocinas/sangue
Regulação da Expressão Gênica/efeitos dos fármacos
Mediadores da Inflamação/fisiologia
Articulações/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos DBA
MicroRNAs/antagonistas & inibidores
Osteoclastos/metabolismo
Osteoprotegerina/metabolismo
Ligante RANK/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type II); 0 (Cytokines); 0 (Inflammation Mediators); 0 (MicroRNAs); 0 (Mirn106 microRNA, mouse); 0 (Osteoprotegerin); 0 (RANK Ligand); 0 (Tnfrsf11b protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex233


  9 / 13013 MEDLINE  
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[PMID]:28957552
[Au] Autor:Mikuls TR; Duryee MJ; Rahman R; Anderson DR; Sayles HR; Hollins A; Michaud K; Wolfe F; Thiele GE; Sokolove J; Robinson WH; Lingampalli N; Nicholas AP; Talmon GA; Su K; Zimmerman MC; Klassen LW; Thiele GM
[Ad] Endereço:Veteran Affairs Nebraska-Western Iowa Health Care System.
[Ti] Título:Enrichment of malondialdehyde-acetaldehyde antibody in the rheumatoid arthritis joint.
[So] Source:Rheumatology (Oxford);56(10):1794-1803, 2017 Oct 01.
[Is] ISSN:1462-0332
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Objective: To characterize the expression of malondialdehdye-acetaldehyde (MAA) adducts and anti-MAA antibody in articular tissues and serum of patients with RA. Methods: Paired sera and SF were examined from 29 RA and 13 OA patients. Anti-MAA antibody, RF, ACPA and total immunoglobulin were quantified. SF-serum measures were compared within and between disease groups. The presence and co-localization of MAA, citrulline and select leukocyte antigens in RA and OA synovial tissues were examined using immunohistochemistry. Results: Circulating and SF anti-MAA antibody concentrations were higher in RA vs OA by 1.5- to 5-fold. IgG (P < 0.001), IgM (P = 0.006) and IgA (P = 0.036) anti-MAA antibodies were higher in paired RA SF than serum, differences not observed for total immunoglobulin, RF or ACPA. In RA synovial tissues, co-localization of MAA with citrulline and CD19+ or CD27+ B cells was demonstrated and was much higher in magnitude than MAA or citrulline co-localization with T cells, monocytes, macrophages or dendritic cells (P < 0.01). Conclusion: Anti-MAA antibodies are present in higher concentrations in the RA joint compared with sera, a finding not observed for other disease-related autoantibodies. Co-localization of MAA and citrulline with mature B cells, coupled with the local enrichment of anti-MAA immune responses, implicates MAA-adduct formation in local autoantibody production.
[Mh] Termos MeSH primário: Acetaldeído/imunologia
Artrite Reumatoide/imunologia
Autoanticorpos/análise
Articulações/imunologia
Malondialdeído/imunologia
[Mh] Termos MeSH secundário: Idoso
Artrite Reumatoide/sangue
Estudos de Casos e Controles
Feminino
Seres Humanos
Imuno-Histoquímica
Masculino
Meia-Idade
Osteoartrite/sangue
Osteoartrite/imunologia
Fator Reumatoide/sangue
Líquido Sinovial/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Autoantibodies); 4Y8F71G49Q (Malondialdehyde); 9009-79-4 (Rheumatoid Factor); GO1N1ZPR3B (Acetaldehyde)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170929
[St] Status:MEDLINE
[do] DOI:10.1093/rheumatology/kex212


  10 / 13013 MEDLINE  
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[PMID]:28942925
[Au] Autor:Wang X; Liu Y; Li X; Zhang Z; Yang H; Zhang Y; Williams PR; Alwahab NSA; Kapur K; Yu B; Zhang Y; Chen M; Ding H; Gerfen CR; Wang KH; He Z
[Ad] Endereço:F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
[Ti] Título:Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills.
[So] Source:Cell;171(2):440-455.e14, 2017 Oct 05.
[Is] ISSN:1097-4172
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control across different species. However, their organizational principle remains unclear. By using a retrograde labeling system, we defined the requirement of CSNs in the execution of a skilled forelimb food-pellet retrieval task in mice. In vivo imaging of CSN activity during performance revealed the sequential activation of topographically ordered functional ensembles with moderate local mixing. Region-specific manipulations indicate that CSNs from caudal or rostral forelimb area control reaching or grasping, respectively, and both are required in the transitional pronation step. These region-specific CSNs terminate in different spinal levels and locations, therefore preferentially connecting with the premotor neurons of muscles engaged in different steps of the task. Together, our findings suggest that spatially defined groups of CSNs encode different movement modules, providing a logic for parallel-ordered corticospinal circuits to orchestrate multistep motor skills.
[Mh] Termos MeSH primário: Medula Cervical/fisiologia
Destreza Motora
Vias Neurais
[Mh] Termos MeSH secundário: Animais
Cálcio/análise
Córtex Cerebral/citologia
Córtex Cerebral/fisiologia
Medula Cervical/citologia
Membro Anterior/fisiologia
Articulações/fisiologia
Camundongos
Camundongos Endogâmicos C57BL
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
SY7Q814VUP (Calcium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE



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