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[PMID]:29346429
[Au] Autor:Ferrigno A; Di Pasqua LG; Berardo C; Siciliano V; Rizzo V; Adorini L; Richelmi P; Vairetti M
[Ad] Endereço:Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy.
[Ti] Título:The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury.
[So] Source:PLoS One;13(1):e0191430, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We previously showed that increased asymmetric dimethylarginine (ADMA) biliary excretion occurs during hepatic ischemia/reperfusion (I/R), prompting us to study the effects of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) on bile, serum and tissue levels of ADMA after I/R. MATERIAL AND METHODS: Male Wistar rats were orally administered 10mg/kg/day of OCA or vehicle for 5 days and were subjected to 60 min partial hepatic ischemia or sham-operated. After a 60 min reperfusion, serum, tissue and bile ADMA levels, liver mRNA and protein expression of ADMA transporters (CAT-1, CAT-2A, CAT-2B, OCT-1, MATE-1), and enzymes involved in ADMA synthesis (protein-arginine-N-methyltransferase-1, PRMT-1) and metabolism (dimethylarginine-dimethylaminohydrolase-1, DDAH-1) were measured. RESULTS: OCA administration induced a further increase in biliary ADMA levels both in sham and I/R groups, with no significant changes in hepatic ADMA content. A reduction in CAT-1, CAT-2A or CAT-2B transcripts was found in OCA-treated sham-operated rats compared with vehicle. Conversely, OCA administration did not change CAT-1, CAT-2A or CAT-2B expression, already reduced by I/R. However, a marked decrease in OCT-1 and increase in MATE-1 expression was observed. A similar trend occurred with protein expression. CONCLUSION: The reduced mRNA expression of hepatic CAT transporters suggests that the increase in serum ADMA levels is probably due to decreased liver uptake of ADMA from the systemic circulation. Conversely, the mechanism involved in further increasing biliary ADMA levels in sham and I/R groups treated with OCA appears to be MATE-1-dependent.
[Mh] Termos MeSH primário: Antiporters/metabolismo
Arginina/análogos & derivados
Sistema Biliar/efeitos dos fármacos
Ácido Quenodesoxicólico/análogos & derivados
Hepatopatias/metabolismo
Proteínas de Transporte de Cátions Orgânicos/metabolismo
Receptores Citoplasmáticos e Nucleares/antagonistas & inibidores
Traumatismo por Reperfusão/metabolismo
Regulação para Cima/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Arginina/sangue
Arginina/metabolismo
Arginina/secreção
Sistema Biliar/metabolismo
Sistema Biliar/secreção
Western Blotting
Proteínas de Transporte/genética
Proteínas de Transporte/metabolismo
Ácido Quenodesoxicólico/farmacologia
Masculino
Óxido Nítrico Sintase/metabolismo
Proteína-Arginina N-Metiltransferases/genética
RNA Mensageiro/genética
Ratos
Ratos Wistar
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiporters); 0 (Carrier Proteins); 0 (MATE1 protein, rat); 0 (Organic Cation Transport Proteins); 0 (RNA, Messenger); 0 (Receptors, Cytoplasmic and Nuclear); 0 (farnesoid X-activated receptor); 0462Z4S4OZ (obeticholic acid); 0GEI24LG0J (Chenodeoxycholic Acid); 63CV1GEK3Y (N,N-dimethylarginine); 94ZLA3W45F (Arginine); EC 1.14.13.39 (Nitric Oxide Synthase); EC 2.1.1.319 (PRMT1 protein, rat); EC 2.1.1.319 (Protein-Arginine N-Methyltransferases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191430


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[PMID]:28453918
[Au] Autor:Vannas MJ; Boyd S; Färkkilä MA; Arola J; Isoniemi H
[Ad] Endereço:Transplantation and Liver Surgery Clinic, Helsinki University Hospital, Helsinki, Finland.
[Ti] Título:Value of brush cytology for optimal timing of liver transplantation in primary sclerosing cholangitis.
[So] Source:Liver Int;37(5):735-742, 2017 May.
[Is] ISSN:1478-3231
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIMS: Primary sclerosing cholangitis is associated with a high risk of cholangiocarcinoma. Here, we investigated the value of surveillance for dysplasia using brush cytology, to determine the optimal timing of liver transplantation in primary sclerosing cholangitis. We compared our preoperative findings, with the final explanted liver histopathology. METHODS: 126 consecutive patients were transplanted for primary sclerosing cholangitis from 1984 to 2012. Patients were divided into two groups: symptomatic (n=91), and asymptomatic (n=35). RESULTS: Brush cytology was available for 101 patients; 66 symptomatic and 35 asymptomatic. Suspicious cytological findings were found in nine patients (14%) in the symptomatic group and 17 (49%) in the asymptomatic group. DNA flow cytometry was available for 49 patients (25 symptomatic, 24 asymptomatic), with aneuploidy detected in six patients (24%) in the symptomatic group and 15 (63%) in the asymptomatic group. Explanted liver histology showed biliary dysplasia or cholangiocarcinoma in 11 symptomatic patients (12%) and 15 asymptomatic patients (43%). A combination of cytological and DNA flow cytometry findings resulted in a test sensitivity of 68%, with a specificity of 86%. Ten-year survival in the asymptomatic group was 91%. CONCLUSIONS: Dysplasia surveillance using brush specimens may help to select those patients likely to benefit from early liver transplantation. It remains unclear as to whether surveillance with brush cytology improves long-term survival, but there is presently no better method with which to predict transplantation timing.
[Mh] Termos MeSH primário: Sistema Biliar/patologia
Colangite Esclerosante/patologia
Colangite Esclerosante/cirurgia
Citodiagnóstico/métodos
Células Epiteliais/patologia
Transplante de Fígado
[Mh] Termos MeSH secundário: Adulto
Neoplasias dos Ductos Biliares/patologia
Carcinoma Hepatocelular/patologia
Colangiocarcinoma/patologia
Colangiopancreatografia Retrógrada Endoscópica
Diagnóstico Diferencial
Feminino
Finlândia
Seres Humanos
Estimativa de Kaplan-Meier
Neoplasias Hepáticas/patologia
Masculino
Meia-Idade
Sistema de Registros
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1111/liv.13276


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[PMID]:28744748
[Au] Autor:Azzam AZ; Tanaka K
[Ad] Endereço:General Surgery Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt. aazzam70@yahoo.com.
[Ti] Título:Biliary complications after living donor liver transplantation: A retrospective analysis of the Kyoto experience 1999-2004.
[So] Source:Indian J Gastroenterol;36(4):296-304, 2017 Jul.
[Is] ISSN:0975-0711
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: In living donor liver transplantation (LDLT), biliary complications continue to be the most frequent cause of morbidity and may contribute to mortality of recipients although there are advances in surgical techniques. This study will evaluate retrospectively the short-term and long-term management of biliary complications. METHODS: During the period from May 1999, to May 2004, 505 patients underwent 518 LDLT in the Department of Liver Transplantation and Immunology, Kyoto University Hospital, Japan. The data was collected and analyzed retrospectively. RESULTS: The recipients were 261 males (50.4%) and 257 females (49.6%). Biliary complications were reported in 202/518 patients (39.0%), included; biliary leakage in 79/518 (15.4%) patients, leakage followed by biloma in 13/518 (2.5%) patients, leakage followed by stricture in 9/518 (1.8%) patients, and biliary strictures in 101/518 (19.3%) patients. Proper management of the biliary complications resulted in a significant (p value 0.002) success rate of 96.5% compared to the failure rate which was 3.5%. CONCLUSION: Careful preoperative evaluation and the proper intraoperative techniques in biliary reconstruction decrease biliary complications. Early diagnosis and proper management of biliary complications can decrease their effect on both the patient and the graft survival over the long period of follow up.
[Mh] Termos MeSH primário: Fístula Anastomótica/epidemiologia
Doenças Biliares/epidemiologia
Sistema Biliar/patologia
Transplante de Fígado
Doadores Vivos
Complicações Pós-Operatórias/epidemiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fístula Anastomótica/prevenção & controle
Doenças Biliares/mortalidade
Doenças Biliares/patologia
Doenças Biliares/prevenção & controle
Procedimentos Cirúrgicos do Sistema Biliar/métodos
Criança
Pré-Escolar
Constrição Patológica
Feminino
Sobrevivência de Enxerto
Seres Humanos
Japão
Transplante de Fígado/mortalidade
Masculino
Meia-Idade
Complicações Pós-Operatórias/mortalidade
Complicações Pós-Operatórias/prevenção & controle
Procedimentos Cirúrgicos Reconstrutivos/métodos
Estudos Retrospectivos
Taxa de Sobrevida
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1007/s12664-017-0771-3


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[PMID]:29376306
[Au] Autor:Basov AA; Bykov IM; Dzhimak SS; Shashkov DI; Malyshko VV; Moiseev AV; Popov KA; Baryshev MG
[Ti] Título:[Influence of linseed oil and deiterium depleted water on isotopic D/H composition and functional antioxidant defense of the hepatobiliary system in rabbits with carbon tetrachloride intoxication].
[So] Source:Vopr Pitan;85(6):30-8, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The article presents results of studying the influence of linseed oil and drinking diet with a modified isotopic composition with low deuterium content on indicators of prooxidant-antioxidant system during modeling of liver toxicity. The research was performed on 36 rabbits (weighing 3.1-3.5 kg) which were divided into 4 groups. Group 1 consisted of control animals; in group 2, 3 and 4 in rabbits the liver toxicity was modeled by administration of CCl4 (intraperitoneally, in the form of a 50% oil solution, 1 ml per kg bw, 2 times a week for 30 days); nutritional correction using flaxseed oil (0.1 ml per 100 g bw) and drinking diet with deuterium depleted water (50 ppm) was carried out in animals from groups 3 and 4 respectively, for 30 days prior to simulation of toxic hepatitis and more throughout the experiment. Using the method of nuclear magnetic resonance and mass spectrometry the influence of deuterium depleted water on D/H composition of the blood plasma, bile and liver tissues was determined: the deuterium concentration in these biological materials significant decreased. The most significant decrease in the deuterium content (30.2% compared with the control group) was found in bloodplasma in animals from group 4. The study of the state of prooxidant-antioxidant balance of the liver and bile showed oxidative stress at the local level, with the toxic effects of carbon tetrachloride. This was followed by EPR spectroscopy data pronounced increase of the number of paramagnetic centers in the hepatocytes by 5.4, 1.9 and 2.8 fold in animals of 2, 3 and 4 groups, respectively (compared to the indicators of the first group). There was also increase in the intensity of free radical oxidation processes in the bile with a simultaneous reduction of its antioxidant activity, which was significantly less distinct (on average 51.18-59.8%, p<0.05) in animals treated with nutritional correction, indicating that higher functional activity of protective systems involved in recycling prooxidant factors using dietary lipophilic antioxidants and water with low deuterium content. Overall, the results of the present study indicate that existing in the liver and bile autonomous mechanisms of regulation of the state of prooxidant-antioxidant systems are quite sensitive to the effects of antioxidant factors of lipophilic nature and shifts of isotopic D/H gradient, and suggest usefulness of the products that can affect these indicators to increase adaptive capabilities of the organism during intoxication.
[Mh] Termos MeSH primário: Antioxidantes/metabolismo
Sistema Biliar/metabolismo
Intoxicação por Tetracloreto de Carbono/metabolismo
Deutério
Óleo de Semente do Linho/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Água/farmacologia
[Mh] Termos MeSH secundário: Animais
Intoxicação por Tetracloreto de Carbono/patologia
Masculino
Coelhos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 059QF0KO0R (Water); 8001-26-1 (Linseed Oil); AR09D82C7G (Deuterium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180130
[St] Status:MEDLINE


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[PMID]:28796833
[Au] Autor:Pereira P; Aho V; Arola J; Boyd S; Jokelainen K; Paulin L; Auvinen P; Färkkilä M
[Ad] Endereço:Institute of Biotechnology, University of Helsinki, Helsinki, Finland.
[Ti] Título:Bile microbiota in primary sclerosing cholangitis: Impact on disease progression and development of biliary dysplasia.
[So] Source:PLoS One;12(8):e0182924, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The etiopathogenesis and risk for development of biliary neoplasia in primary sclerosing cholangitis (PSC) are largely unknown. Microbes or their metabolites have been suggested to play a role. To explore this potential microbial involvement, we evaluated the differences in biliary microbiota in PSC patients at an early disease stage without previous endoscopic retrograde cholangiography (ERC) examinations, advanced disease stage, and with biliary dysplasia or cholangiocarcinoma. DESIGN: Bile samples from the common bile duct were collected from 46 controls and 80 patients with PSC during ERC (37 with early disease, 32 with advanced disease, and 11 with biliary dysplasia). DNA isolation, amplification, and Illumina MiSeq sequencing were performed for the V1-V3 regions of the bacterial 16S rRNA gene. RESULTS: The most common phyla found were Bacteroidetes, Firmicutes, Proteobacteria, Fusobacteria, and Actinobacteria. The most common families were Prevotellaceae, Streptococcaceae, Veillonellaceae, Fusobacteriaceae, and Pasteurellaceae, and the most common genera were Prevotella, Streptococcus, Veillonella, Fusobacterium, and Haemophilus. The bacterial communities of non-PSC subjects and early stage PSC patients were similar. Alpha diversity was lower in patients with biliary dysplasia/cholangiocarcinoma than in other groups. An increase in Streptococcus abundance was positively correlated with the number of ERC examinations. Streptococcus abundance was also positively correlated with an increase in disease severity, even after controlling for the number of ERC examinations. CONCLUSIONS: Our findings suggest that the aetiology of PSC is not associated with changes in bile microbial communities, but the genus Streptococcus may play a pathogenic role in the progression of the disease.
[Mh] Termos MeSH primário: Bactérias/isolamento & purificação
Bile/microbiologia
Colangite Esclerosante/microbiologia
Microbiota
[Mh] Termos MeSH secundário: Adulto
Bactérias/genética
Sistema Biliar/microbiologia
Sistema Biliar/patologia
Colangite Esclerosante/patologia
DNA Bacteriano/genética
DNA Bacteriano/isolamento & purificação
Progressão da Doença
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170811
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182924


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[PMID]:28671689
[Au] Autor:Sampaziotis F; Justin AW; Tysoe OC; Sawiak S; Godfrey EM; Upponi SS; Gieseck RL; de Brito MC; Berntsen NL; Gómez-Vázquez MJ; Ortmann D; Yiangou L; Ross A; Bargehr J; Bertero A; Zonneveld MCF; Pedersen MT; Pawlowski M; Valestrand L; Madrigal P; Georgakopoulos N; Pirmadjid N; Skeldon GM; Casey J; Shu W; Materek PM; Snijders KE; Brown SE; Rimland CA; Simonic I; Davies SE; Jensen KB; Zilbauer M; Gelson WTH; Alexander GJ; Sinha S; Hannan NRF; Wynn TA; Karlsen TH; Melum E; Markaki AE; Saeb-Parsy K; Vallier L
[Ad] Endereço:Wellcome Trust-Medical Research Council Stem Cell Institute, Cambridge Stem Cell Institute, Anne McLaren Laboratory, University of Cambridge, Cambridge, UK.
[Ti] Título:Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids.
[So] Source:Nat Med;23(8):954-963, 2017 Aug.
[Is] ISSN:1546-170X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The treatment of common bile duct (CBD) disorders, such as biliary atresia or ischemic strictures, is restricted by the lack of biliary tissue from healthy donors suitable for surgical reconstruction. Here we report a new method for the isolation and propagation of human cholangiocytes from the extrahepatic biliary tree in the form of extrahepatic cholangiocyte organoids (ECOs) for regenerative medicine applications. The resulting ECOs closely resemble primary cholangiocytes in terms of their transcriptomic profile and functional properties. We explore the regenerative potential of these organoids in vivo and demonstrate that ECOs self-organize into bile duct-like tubes expressing biliary markers following transplantation under the kidney capsule of immunocompromised mice. In addition, when seeded on biodegradable scaffolds, ECOs form tissue-like structures retaining biliary characteristics. The resulting bioengineered tissue can reconstruct the gallbladder wall and repair the biliary epithelium following transplantation into a mouse model of injury. Furthermore, bioengineered artificial ducts can replace the native CBD, with no evidence of cholestasis or occlusion of the lumen. In conclusion, ECOs can successfully reconstruct the biliary tree, providing proof of principle for organ regeneration using human primary cholangiocytes expanded in vitro.
[Mh] Termos MeSH primário: Ductos Biliares Extra-Hepáticos/fisiologia
Células Epiteliais/citologia
Vesícula Biliar/fisiologia
Organoides/fisiologia
Regeneração/fisiologia
Engenharia Tecidual/métodos
[Mh] Termos MeSH secundário: Animais
Ductos Biliares Extra-Hepáticos/citologia
Ductos Biliares Extra-Hepáticos/lesões
Sistema Biliar/citologia
Sistema Biliar/lesões
Sistema Biliar/fisiologia
Transplante de Células
Regulador de Condutância Transmembrana em Fibrose Cística/metabolismo
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/metabolismo
Vesícula Biliar/lesões
Seres Humanos
Técnicas In Vitro
Queratina-19/metabolismo
Queratina-7/metabolismo
Camundongos
Organoides/citologia
Organoides/efeitos dos fármacos
Organoides/metabolismo
Secretina/farmacologia
Somatostatina/farmacologia
Tecidos Suporte
gama-Glutamiltransferase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; VIDEO-AUDIO MEDIA
[Nm] Nome de substância:
0 (Keratin-19); 0 (Keratin-7); 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator); 1393-25-5 (Secretin); 51110-01-1 (Somatostatin); EC 2.3.2.2 (gamma-Glutamyltransferase)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1038/nm.4360


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[PMID]:28650239
[Au] Autor:Chau J; Podadera JM; Young AC; Makara MA
[Ti] Título:Use of gadoxetic acid for computed tomographic cholangiography in healthy dogs.
[So] Source:Am J Vet Res;78(7):828-839, 2017 Jul.
[Is] ISSN:1943-5681
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE To evaluate the effect of gadoxetic acid (contrast) dose on biliary tract enhancement, determine the optimal time after contrast injection for CT image acquisition, and assess the feasibility of CT cholangiography in sedated dogs. ANIMALS 8 healthy dogs. PROCEDURES The study had 2 parts. In part 1, 4 dogs were anesthetized and underwent CT cholangiography twice. Gadoxetic acid was administered IV at a low dose (0.025 mmol/kg) for the first procedure and high dose (0.3 mmol/kg) for the second procedure. Serial CT scans were obtained at predetermined times after contrast injection. In part 2, 4 dogs were sedated and underwent CT angiography 85 minutes after IV administration of the high contrast dose. Contrast enhancement of the biliary tract on all scans was objectively assessed by measurement of CT attenuation and qualitatively assessed by use of a subjective 4-point scoring system by 3 independent reviewers. All measurements were compared over time and between contrast doses for the dogs of part 1. Subjective measurements were compared between the sedated dogs of part 2 and anesthetized dogs of part 1. RESULTS Enhancement of the biliary tract was positively associated with contrast dose and time after contrast injection. Optimal enhancement was achieved 65 minutes after contrast injection. Subjective visualization of most biliary structures did not differ significantly between sedated and anesthetized dogs. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated CT cholangiography with gadoxetic acid was feasible in sedated dogs. The high contrast dose provided better visualization of biliary structures than the low dose; CT scans should be obtained 65 minutes after contrast injection.
[Mh] Termos MeSH primário: Colangiografia/veterinária
Meios de Contraste/administração & dosagem
Cães
Gadolínio DTPA/administração & dosagem
Tomografia Computadorizada por Raios X/veterinária
[Mh] Termos MeSH secundário: Animais
Sistema Biliar
Colangiografia/métodos
Estudos de Viabilidade
Feminino
Injeções Intravenosas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); 0 (gadolinium ethoxybenzyl DTPA); K2I13DR72L (Gadolinium DTPA)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171108
[Lr] Data última revisão:
171108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE
[do] DOI:10.2460/ajvr.78.7.828


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[PMID]:28526690
[Au] Autor:Fabris L; Spirli C; Cadamuro M; Fiorotto R; Strazzabosco M
[Ad] Endereço:Department of Molecular Medicine, University of Padua School of Medicine, Padua, Italy; luca.fabris@unipd.it.
[Ti] Título:Emerging concepts in biliary repair and fibrosis.
[So] Source:Am J Physiol Gastrointest Liver Physiol;313(2):G102-G116, 2017 Aug 01.
[Is] ISSN:1522-1547
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chronic diseases of the biliary tree (cholangiopathies) represent one of the major unmet needs in clinical hepatology and a significant knowledge gap in liver pathophysiology. The common theme in cholangiopathies is that the target of the disease is the biliary tree. After damage to the biliary epithelium, inflammatory changes stimulate a reparative response with proliferation of cholangiocytes and restoration of the biliary architecture, owing to the reactivation of a variety of morphogenetic signals. Chronic damage and inflammation will ultimately result in pathological repair with generation of biliary fibrosis and clinical progression of the disease. The hallmark of pathological biliary repair is the appearance of reactive ductular cells, a population of cholangiocyte-like epithelial cells of unclear and likely mixed origin that are able to orchestrate a complex process that involves a number of different cell types, under joint control of inflammatory and morphogenetic signals. Several questions remain open concerning the histogenesis of reactive ductular cells, their role in liver repair, their mechanism of activation, and the signals exchanged with the other cellular elements cooperating in the reparative process. This review contributes to the current debate by highlighting a number of new concepts derived from the study of the pathophysiology of chronic cholangiopathies, such as congenital hepatic fibrosis, biliary atresia, and Alagille syndrome.
[Mh] Termos MeSH primário: Doenças dos Ductos Biliares/patologia
Hepatopatias/patologia
[Mh] Termos MeSH secundário: Animais
Sistema Biliar/patologia
Fibrose/patologia
Seres Humanos
Fígado/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170521
[St] Status:MEDLINE
[do] DOI:10.1152/ajpgi.00452.2016


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[PMID]:28324003
[Au] Autor:Kettunen JLT; Parviainen H; Miettinen PJ; Färkkilä M; Tamminen M; Salonen P; Lantto E; Tuomi T
[Ad] Endereço:Department of Endocrinology, Abdominal Centre, Helsinki University Hospital, Helsinki 00029, Finland.
[Ti] Título:Biliary Anomalies in Patients With HNF1B Diabetes.
[So] Source:J Clin Endocrinol Metab;102(6):2075-2082, 2017 Jun 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: The clinical spectrum of organogenetic anomalies associated with HNF1B mutations is heterogeneous. Besides cystic kidney disease, diabetes, and various other manifestations, odd cases of mainly neonatal and posttransplantation cholestasis have been described. The biliary phenotype is incompletely defined. Objective: To systematically characterize HNF1B-related anomalies in the bile ducts by imaging with magnetic resonance imaging (MRI) or magnetic resonance cholangiopancreatography (MRCP). Setting and Patients: Fourteen patients with HNF1B mutations in the catchment area of the Helsinki University Hospital were evaluated with upper abdominal MRI and MRCP. Blood samples and clinical history provided supplemental data on the individual phenotype. Main Outcome Measure(s): Structural anomalies in the biliary system, medical history of cholestasis, other findings in abdominal organs, diabetes and antihyperglycemic treatment, hypomagnesemia, and hyperuricemia. Results: Structural anomalies of the bile ducts were found in seven of 14 patients (50%). Six patients had choledochal cysts, which are generally considered premalignant. Conclusions: Structural anomalies of the biliary system were common in HNF1B mutation carriers. The malignant potential of HNF1B-associated choledochal cysts warrants further studies.
[Mh] Termos MeSH primário: Cisto do Colédoco/genética
Diabetes Mellitus Tipo 2/genética
Fator 1-beta Nuclear de Hepatócito/genética
Doenças Renais Císticas/genética
Pâncreas/anormalidades
Pancreatopatias/congênito
Anormalidades Urogenitais/genética
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Sistema Biliar/anormalidades
Sistema Biliar/diagnóstico por imagem
Criança
Colangiopancreatografia por Ressonância Magnética
Cisto do Colédoco/diagnóstico por imagem
Feminino
Finlândia
Seres Humanos
Doenças Renais Císticas/diagnóstico por imagem
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Mutação
Pâncreas/diagnóstico por imagem
Pancreatopatias/diagnóstico por imagem
Pancreatopatias/genética
Fenótipo
Anormalidades Urogenitais/diagnóstico por imagem
Útero/anormalidades
Útero/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (HNF1B protein, human); 138674-15-4 (Hepatocyte Nuclear Factor 1-beta)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2017-00061


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[PMID]:28216982
[Au] Autor:Yasuda M; Sato H; Koyama Y; Sakakida T; Kawakami T; Nishimura T; Fujii H; Nakatsugawa Y; Yamada S; Tomatsuri N; Okuyama Y; Kimura H; Ito T; Morishita H; Yoshida N
[Ad] Endereço:Muneji Yasuda, Hideki Sato, Yuki Koyama, Tomoki Sakakida, Takumi Kawakami, Takeshi Nishimura, Hideki Fujii, Yoshikazu Nakatsugawa, Shinya Yamada, Naoya Tomatsuri, Yusuke Okuyama, Hiroyuki Kimura, Norimasa Yoshida, Department of Gastroenterology and Hepatology, Japanese Red Cross Kyoto Daiichi Hospit
[Ti] Título:Late-onset severe biliary bleeding after endoscopic pigtail plastic stent insertion.
[So] Source:World J Gastroenterol;23(4):735-739, 2017 Jan 28.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Here, we report our experience with a case of severe biliary bleeding due to a hepatic arterial pseudoaneurysm that had developed 1 year after endoscopic biliary plastic stent insertion. The patient, a 78-year-old woman, presented with hematemesis and obstructive jaundice. Ruptured hepatic arterial pseudoaneurysm was diagnosed, which was suspected to have been caused by long-term placement of an endoscopic retrograde biliary drainage (ERBD) stent. This episode of biliary bleeding was successfully treated by transarterial embolization (TAE). Pseudoaneurysm leading to hemobilia is a rare but potentially fatal complication in patients with long-term placement of ERBD. TAE is a minimally invasive procedure that offers effective treatment for biliary bleeding.
[Mh] Termos MeSH primário: Sistema Biliar/patologia
Artéria Hepática/patologia
Plásticos/efeitos adversos
Stents/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Falso Aneurisma
Colangiopancreatografia Retrógrada Endoscópica/efeitos adversos
Angiografia por Tomografia Computadorizada
Drenagem/métodos
Embolização Terapêutica/métodos
Feminino
Hematemese
Hemobilia/etiologia
Hemorragia
Seres Humanos
Incidência
Icterícia Obstrutiva/diagnóstico
Implante de Prótese/efeitos adversos
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plastics)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i4.735



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