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[PMID]:28453692
[Au] Autor:Ott PA; Piha-Paul SA; Munster P; Pishvaian MJ; van Brummelen EMJ; Cohen RB; Gomez-Roca C; Ejadi S; Stein M; Chan E; Simonelli M; Morosky A; Saraf S; Emancipator K; Koshiji M; Bennouna J
[Ad] Endereço:Center for Immuno-Oncology, Dana-Farber Cancer Institute, Boston, USA.
[Ti] Título:Safety and antitumor activity of the anti-PD-1 antibody pembrolizumab in patients with recurrent carcinoma of the anal canal.
[So] Source:Ann Oncol;28(5):1036-1041, 2017 05 01.
[Is] ISSN:1569-8041
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: Safety and efficacy of pembrolizumab, a humanized programmed death 1 monoclonal antibody, was assessed in KEYNOTE-028, a multicohort, phase Ib trial for patients with programmed death ligand 1 (PD-L1)-positive advanced solid tumors. We report results for the cohort of patients with advanced anal carcinoma. Patients and methods: Patients with PD-L1-positive tumors (≥1%) received intravenous pembrolizumab 10 mg/kg once every 2 weeks for up to 2 years or until confirmed progression or unacceptable toxicity. Response was assessed every 8 weeks for the first 6 months and every 12 weeks thereafter per Response Evaluation Criteria In Solid Tumors, version 1.1. Primary endpoints were safety and overall response rate per investigator review. Secondary endpoints included progression-free survival, overall survival, and response duration. Data cutoff date was 1 July 2015. Results: Of the 43 patients with advanced anal carcinoma evaluable for PD-L1 expression, 32 (74%) had PD-L1-positive tumors as assessed with the 22C3 prototype assay, of whom 25 were enrolled between April and September 2014. Sixteen patients (64%) experienced treatment-related adverse events; the most common ones were diarrhea and fatigue in four patients (16%) each and nausea in three patients (12%). There were no treatment-related deaths or discontinuations as of the data cutoff date. Among the 24 patients with squamous cell carcinoma histology, four had confirmed partial response, for an overall response rate of 17% [95% confidence interval (CI), 5%-37%) and 10 (42%) had confirmed stable disease, for a disease control rate of 58%. One additional patient with non-squamous histology had confirmed stable disease. Conclusion: In this population of patients with PD-L1-positive advanced squamous cell anal carcinoma, pembrolizumab demonstrated a manageable safety profile and encouraging antitumor activity. These data support further study of pembrolizumab for this patient population. ClinicalTrials.gov: NCT02054806.
[Mh] Termos MeSH primário: Anticorpos Monoclonais Humanizados/uso terapêutico
Antineoplásicos Imunológicos/uso terapêutico
Neoplasias do Ânus/tratamento farmacológico
Carcinoma de Células Escamosas/tratamento farmacológico
Recidiva Local de Neoplasia/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Canal Anal/patologia
Anticorpos Monoclonais Humanizados/efeitos adversos
Antineoplásicos Imunológicos/efeitos adversos
Neoplasias do Ânus/mortalidade
Carcinoma de Células Escamosas/mortalidade
Intervalo Livre de Doença
Feminino
Seres Humanos
Masculino
Meia-Idade
Recidiva Local de Neoplasia/mortalidade
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Antibodies, Monoclonal, Humanized); 0 (Antineoplastic Agents, Immunological); DPT0O3T46P (pembrolizumab)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1093/annonc/mdx029


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[PMID]:29240487
[Au] Autor:Woodward S
[Ad] Endereço:Head of Clinical Education, Florence Nightingale Faculty of Nursing, King's College London.
[Ti] Título:Treating chronic constipation and faecal incontinence using transanal irrigation.
[So] Source:Br J Nurs;26(22):1220-1222, 2017 Dec 14.
[Is] ISSN:0966-0461
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Constipação Intestinal/enfermagem
Incontinência Fecal/enfermagem
Irrigação Terapêutica
[Mh] Termos MeSH secundário: Canal Anal
Seres Humanos
Irrigação Terapêutica/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.12968/bjon.2017.26.22.1220


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[PMID]:28464996
[Au] Autor:Streller T; Rusch U; Herraiz Lablanca MD; Minneken I; Najafi Y; Shrestha B; Oertel S; Riesterer O
[Ad] Endereço:Department of Radiation Oncology, University Hospital of Zurich, Switzerland.
[Ti] Título:The effect of endorectal balloon on anorectal dose during postoperative volumetric arc radiotherapy of prostate cancer.
[So] Source:Radiother Oncol;123(3):454-458, 2017 06.
[Is] ISSN:1879-0887
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the impact of endorectal balloon (ERB) on anorectal dose during postoperative VMAT of prostate cancer. METHODS: In ten patients referred for salvage radiotherapy CTs were obtained without ERB and with air-filled ERB of 50ml and 100ml. CTs were repeated weekly (4-6 control CTs) and registered to the respective planning CT. For each planning CT, a VMAT plan was made with defined anorectal dose constraints and propagated on the respective control CTs. The dose volumes V40Gy, V60Gy and V65Gy of the rectal and anal wall (Rwall and Awall, respectively) and the ERB position were obtained from each plan. RESULTS: In plans with ERB, the mean Rwall dose volumes V40Gy, V60Gy and V65Gy were higher by 8%, 5% and 2% (ERB 50ml) and 2%, 3% and 3% (ERB 100ml) in comparison to plans without ERB. The respective Awall dose volume differences were 2%, 0%, -1% (ERB 50ml), and -3%, -2%, -2% (ERB 100ml). The dose volume variability of the Rwall was comparable with and without ERB, but was slightly reduced by ERB for the Awall. The mean ERB position variability was >2mm in anterior-posterior and inferior-superior directions. CONCLUSION: The use of ERB during post-operative VMAT has no advantages for anorectal dose.
[Mh] Termos MeSH primário: Neoplasias da Próstata/radioterapia
Radioterapia de Intensidade Modulada/métodos
[Mh] Termos MeSH secundário: Canal Anal/efeitos da radiação
Seres Humanos
Masculino
Estudos Prospectivos
Neoplasias da Próstata/cirurgia
Dosagem Radioterapêutica
Planejamento da Radioterapia Assistida por Computador
Reto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180120
[Lr] Data última revisão:
180120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE


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[PMID]:29237118
[Au] Autor:Tucker J; Wilson A; Clifton VL
[Ti] Título:IMPROVING COMMUNICATION AROUND ANAL INCONTINENCE FOR WOMEN OF REPRODUCTIVE AGE.
[So] Source:Aust Nurs Midwifery J;24(1):37, 2016 07.
[Is] ISSN:2202-7114
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Anal incontinence (AI) is the accidental loss of liquid or solid stool and flatus (Milsom et al. 2009). The concept of uncontrolled faecal loss can evoke social disgust and marginalize those afflicted from the community in which they live (Williams et al. 2005).
[Mh] Termos MeSH primário: Incontinência Fecal/etiologia
Incontinência Fecal/enfermagem
Incontinência Fecal/fisiopatologia
Papel do Profissional de Enfermagem
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Canal Anal/fisiopatologia
Parto Obstétrico/efeitos adversos
Feminino
Seres Humanos
Qualidade de Vida
Isolamento Social
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:171214
[St] Status:MEDLINE


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[PMID]:27770550
[Au] Autor:Sultan AH; Monga A; Lee J; Emmanuel A; Norton C; Santoro G; Hull T; Berghmans B; Brody S; Haylen BT
[Ad] Endereço:Urogynaecologist and Obstetrician, Croydon University Hospital, Croydon, United Kingdom.
[Ti] Título:An International Urogynecological Association (IUGA)/International Continence Society (ICS) joint report on the terminology for female anorectal dysfunction.
[So] Source:Neurourol Urodyn;36(1):10-34, 2017 01.
[Is] ISSN:1520-6777
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The terminology for anorectal dysfunction in women has long been in need of a specific clinically-based Consensus Report. METHODS: This Report combines the input of members of the Standardization and Terminology Committees of two International Organizations, the International Urogynecological Association (IUGA) and the International Continence Society (ICS), assisted on Committee by experts in their fields to form a Joint IUGA/ICS Working Group on Female Anorectal Terminology. Appropriate core clinical categories and sub classifications were developed to give an alphanumeric coding to each definition. An extensive process of twenty rounds of internal and external review was developed to exhaustively examine each definition, with decision-making by collective opinion (consensus). RESULTS: A Terminology Report for anorectal dysfunction, encompassing over 130 separate definitions, has been developed. It is clinically based with the most common diagnoses defined. Clarity and user-friendliness have been key aims to make it interpretable by practitioners and trainees in all the different specialty groups involved in female pelvic floor dysfunction. Female-specific anorectal investigations and imaging (ultrasound, radiology and MRI) has been included whilst appropriate figures have been included to supplement and help clarify the text. Interval review (5-10 years) is anticipated to keep the document updated and as widely acceptable as possible. CONCLUSION: A consensus-based Terminology Report for female anorectal dysfunction terminology has been produced aimed at being a significant aid to clinical practice and a stimulus for research. Neurourol. Urodynam. 36:10-34, 2017. © 2016 Wiley Periodicals, Inc., and The International Urogynecological Association.
[Mh] Termos MeSH primário: Canal Anal
Ginecologia/normas
Doenças Retais/classificação
Doenças Retais/fisiopatologia
Terminologia como Assunto
Urologia/normas
[Mh] Termos MeSH secundário: Canal Anal/diagnóstico por imagem
Canal Anal/fisiopatologia
Consenso
Exame Retal Digital
Feminino
Seres Humanos
Doenças Retais/diagnóstico
Doenças Retais/diagnóstico por imagem
Sociedades Médicas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE
[do] DOI:10.1002/nau.23055


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[PMID]:28455798
[Au] Autor:Obata S; Fukahori S; Yagi M; Suzuki M; Ueno S; Ushijima K; Taguchi T
[Ad] Endereço:Department of Pediatric Surgery, Graduate School of Medical Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan.
[Ti] Título:Internal anal sphincter achalasia: data from a nationwide survey of allied disorders of Hirschsprung's disease in Japan.
[So] Source:Surg Today;47(12):1429-1433, 2017 Dec.
[Is] ISSN:1436-2813
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To investigate the incidence and treatment of internal anal sphincter achalasia (IASA) in Japan based on an analysis of data from a nationwide retrospective cohort study of the allied disorders of Hirschsprung's disease. METHODS: Five cases of definitive IASA were collected from a nationwide retrospective cohort study conducted from 2001 to 2010 and a search of the Japanese literature. RESULTS: Symptoms developed during the neonatal period in two patients, during early childhood in two, and at school age in one. Symptoms included abdominal distension with severe constipation (n = 4) and enterocolitis (n = 1). Rectocolonography showed megarectum and no narrow segment in most of the patients. All patients were negative for rectosphincteric reflex. The presence of ganglion cells was demonstrated by H&E or AChE staining from rectal mucosal biopsies or resected full-thickness segments. Two patients were treated conservatively, and three were treated surgically by internal anal sphincter myotomy (n = 2) or Lynn procedure (n = 1), with satisfactory outcomes. CONCLUSION: IASA is a rare but distinct entity in Japan. Although the clinical features of IASA resemble those of short- and ultrashort-segment HD, characteristic pathological findings include the presence of ganglion cells. The outcomes of both conservative and surgical treatment are good.
[Mh] Termos MeSH primário: Doença de Hirschsprung/terapia
[Mh] Termos MeSH secundário: Canal Anal/cirurgia
Criança
Pré-Escolar
Estudos de Coortes
Procedimentos Cirúrgicos do Sistema Digestório/métodos
Feminino
Doença de Hirschsprung/diagnóstico
Doença de Hirschsprung/epidemiologia
Doença de Hirschsprung/patologia
Seres Humanos
Incidência
Recém-Nascido
Japão/epidemiologia
Masculino
Miotomia
Reto/patologia
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1007/s00595-017-1532-8


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[PMID]:29215481
[Au] Autor:Xu Z; Fleming FJ; Justiniano CF; Becerra AZ; Boodry CI; Aquina CT; Temple LK; Speranza JR
[Ad] Endereço:Department of Surgery, University of Rochester Medical Center, Rochester, New York.
[Ti] Título:Trends in Surgeon-Level Utilization of Sacral Nerve Stimulator Implantation for Fecal Incontinence in New York State.
[So] Source:Dis Colon Rectum;61(1):107-114, 2018 Jan.
[Is] ISSN:1530-0358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: There is a paucity of real-world data regarding surgeon utilization of sacral nerve stimulation for fecal incontinence compared with anal sphincteroplasty. OBJECTIVE: This study aims to examine trends in sacral nerve stimulation use compared with sphincteroplasty for fecal incontinence and surgeon-level variation in progression to implantation of the pulse generator. DESIGN: This is a population-based study. PATIENTS: Patients with fecal incontinence between 2011 and 2014 in New York who underwent stage 1 of the sacral nerve stimulation procedure were selected. For the comparison with sphincteroplasty, patients with fecal incontinence who underwent anal sphincteroplasty between 2008 and 2014 were included. MAIN OUTCOME MEASURES: The main outcomes after sacral nerve stimulation generator placement were unplanned 30-day admission, emergency department visit within 30 days, revision or explant of leads or generator, and 30-day mortality. RESULTS: Six hundred twenty-one patients with fecal incontinence underwent a stage 1 procedure with 79.7% progressing to stage 2. There has been an increase in the number of sacral nerve stimulation cases per year as well as the number of surgeons performing the procedure. The rate of progression to stage 2 among patients treated by colorectal surgeons was 80.2% compared with 77.0% among those treated by noncolorectal surgeons. Among those who completed stage 2, there were 3 (0.5%) unplanned 30-day admissions, 24 (4.4%) emergency department visits within 30 days, and 0 mortalities within 30 days. Thirty-two (6.5%) patients had their leads or pulse generator revised or explanted. There was a significant decrease in annual sphincteroplasty cases and the number of providers performing the procedure starting in 2011. LIMITATIONS: We lacked data regarding patient and physician decision making and the severity of disease. CONCLUSIONS: Sacral nerve stimulation for fecal incontinence is increasing in popularity with an increasing number of surgeons utilizing sacral nerve stimulation for fecal incontinence rather than sphincteroplasty. See Video Abstract at http://links.lww.com/DCR/A450.
[Mh] Termos MeSH primário: Terapia por Estimulação Elétrica/utilização
Incontinência Fecal/cirurgia
Plexo Lombossacral/cirurgia
Esfincterotomia/métodos
[Mh] Termos MeSH secundário: Idoso
Canal Anal/cirurgia
Terapia por Estimulação Elétrica/tendências
Eletrodos Implantados/tendências
Eletrodos Implantados/utilização
Feminino
Seres Humanos
Masculino
Meia-Idade
New York
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/DCR.0000000000000941


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[PMID]:29215479
[Au] Autor:Toh JWT; Wang N; Young CJ; Rickard MJFX; Keshava A; Stewart P; Kariyawasam V; Leong R; and the Sydney IBD Cohort Collaborators
[Ad] Endereço:Division of Colorectal Surgery, Department of Surgery, Westmead Hospital, The University of Sydney, Westmead Clinical School, Sydney, New South Wales, Australia.
[Ti] Título:Major Abdominal and Perianal Surgery in Crohn's Disease: Long-term Follow-up of Australian Patients With Crohn's Disease.
[So] Source:Dis Colon Rectum;61(1):67-76, 2018 Jan.
[Is] ISSN:1530-0358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Most patients with Crohn's disease still require surgery despite significant advances in medical therapy, surveillance, and management strategies. OBJECTIVE: The purpose of this study was to assess surgical strategies and outcomes in Crohn's disease, including surgical recurrence and emergency surgery. DESIGN: This was a multicenter, retrospective review of a prospectively collected database. SETTINGS: A specialist-referred cohort of patients with Crohn's disease between 1970 and 2009 was studied. PATIENTS: Included were 972 patients with Crohn's disease who were referred to the Sydney Inflammatory Bowel Disease cohort database. MAIN OUTCOME MEASURES: Main outcomes of interest were the rates of major abdominal and perianal surgery between decades (1970-1979, 1980-1989, 1990-1999, and 2000-2009), indications for surgery, types of procedure performed, rate of elective and emergency surgery, risk of surgical recurrence, and predictive factors for surgery. RESULTS: Between 1970 and 2009, the overall risks of surgery within 5, 10, and 15 years of diagnosis were 31.7%, 43.3%, and 48.4%. The median time to first surgery from time of diagnosis was 2 years (range, 0-31 years). A total of 6.7% of patients required emergency surgery within 5 years of diagnosis. In total, 8.8% of patients required emergency surgery within 15 years. The overall risk of surgical recurrence was 35.9%. The risk of major abdominal surgery significantly decreased between 2000 and 2009 when compared with the 1970 to 1979 period (OR = 0.49 (95% CI, 0.34-0.70). However, the rate of perianal surgery significantly increased (OR = 5.76 (95% CI, 2.54-13.06)). The main indications for surgery were enteric stricture or obstruction, perianal disease, and intra-abdominal fistulas/abscess. Of the 972 patients over 4 decades, only 11 patients (1.1%) were diagnosed with colorectal cancer. LIMITATIONS: This was a specialist-referred cohort, not a population-based study. CONCLUSIONS: The rate of major abdominal surgery has decreased, with surgery reserved for more severe and complicated disease. The natural history of patients with more complicated Crohn's disease and severe phenotypes puts them at higher risk of surgical recurrence and emergency surgery. There has been no reduction in emergency surgery rates and there has been an increase in surgical recurrence despite the reduction in surgical rate morbidity. See Video Abstract at http://links.lww.com/DCR/A483.
[Mh] Termos MeSH primário: Canal Anal/cirurgia
Doença de Crohn/epidemiologia
Doença de Crohn/cirurgia
Procedimentos Cirúrgicos do Sistema Digestório/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adolescente
Adulto
Austrália/epidemiologia
Procedimentos Cirúrgicos do Sistema Digestório/tendências
Procedimentos Cirúrgicos Eletivos/estatística & dados numéricos
Procedimentos Cirúrgicos Eletivos/tendências
Feminino
Seguimentos
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171215
[Lr] Data última revisão:
171215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1097/DCR.0000000000000975


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[PMID]:29080750
[Au] Autor:Mo D; Zhao Y; Balajee AS
[Ad] Endereço:Chinese Academy of Science, Beijing Institute of Genomics, Beijing CN 100029, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Human RecQL4 helicase plays multifaceted roles in the genomic stability of normal and cancer cells.
[So] Source:Cancer Lett;413:1-10, 2018 Jan 28.
[Is] ISSN:1872-7980
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Human RecQ helicases that share homology with E. coli RecQ helicase play critical roles in diverse biological activities such as DNA replication, transcription, recombination and repair. Mutations in three of the five human RecQ helicases (RecQ1, WRN, BLM, RecQL4 and RecQ5) result in autosomal recessive syndromes characterized by accelerated aging symptoms and cancer incidence. Mutational inactivation of Werner (WRN) and Bloom (BLM) genes results in Werner syndrome (WS) and Bloom syndrome (BS) respectively. However, mutations in RecQL4 result in three human disorders: (I) Rothmund-Thomson syndrome (RTS), (II) RAPADILINO and (III) Baller-Gerold syndrome (BGS). Cells from WS, BS and RTS are characterized by a unique chromosomal anomaly indicating that each of the RecQ helicases performs specialized function(s) in a non-redundant manner. Elucidating the biological functions of RecQ helicases will enable us to understand not only the aging process but also to determine the cause for age-associated human diseases. Recent biochemical and molecular studies have given new insights into the multifaceted roles of RecQL4 that range from genomic stability to carcinogenesis and beyond. This review summarizes some of the existing and emerging knowledge on diverse biological functions of RecQL4 and its significance as a potential molecular target for cancer therapy.
[Mh] Termos MeSH primário: Canal Anal/anormalidades
Biomarcadores Tumorais/metabolismo
Transformação Celular Neoplásica/metabolismo
Craniossinostoses/enzimologia
Nanismo/enzimologia
Instabilidade Genômica
Comunicação Interatrial/enzimologia
Deformidades Congênitas dos Membros/enzimologia
Neoplasias/enzimologia
Patela/anormalidades
Rádio (Anatomia)/anormalidades
RecQ Helicases/metabolismo
Síndrome de Rothmund-Thomson/enzimologia
[Mh] Termos MeSH secundário: Canal Anal/enzimologia
Antineoplásicos/uso terapêutico
Biomarcadores Tumorais/antagonistas & inibidores
Biomarcadores Tumorais/genética
Proliferação Celular
Transformação Celular Neoplásica/genética
Transformação Celular Neoplásica/patologia
Craniossinostoses/genética
Reparo do DNA
Replicação do DNA
DNA Mitocondrial/genética
DNA Mitocondrial/metabolismo
Nanismo/genética
Inibidores Enzimáticos/uso terapêutico
Predisposição Genética para Doença
Comunicação Interatrial/genética
Seres Humanos
Deformidades Congênitas dos Membros/genética
Mutação
Neoplasias/tratamento farmacológico
Neoplasias/genética
Neoplasias/patologia
Patela/enzimologia
Fenótipo
Rádio (Anatomia)/enzimologia
RecQ Helicases/antagonistas & inibidores
RecQ Helicases/genética
Síndrome de Rothmund-Thomson/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers, Tumor); 0 (DNA, Mitochondrial); 0 (Enzyme Inhibitors); EC 3.6.1.- (RECQL4 protein, human); EC 3.6.4.12 (RecQ Helicases)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171030
[St] Status:MEDLINE


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[PMID]:27771095
[Au] Autor:Bjelanovic Z; Draskovic M; Veljovic M; Lekovic I; Karanikolas M; Stamenkovic D
[Ad] Endereço:Clinic for Vascular and Endovascular Surgery, Military Medical Academy, Belgrado, Serbia. Electronic address: vojislavma2@sbb.rs.
[Ti] Título:Transanal hemorrhoid dearterialization is a safe and effective outpatient procedure for the treatment of hemorrhoidal disease.
[Ti] Título:Desarterialización hemorroidal transanal, un procedimiento seguro y eficaz para el tratamiento ambulatorio de la enfermedad hemorroidal..
[So] Source:Cir Esp;94(10):588-594, 2016 Dec.
[Is] ISSN:1578-147X
[Cp] País de publicação:Spain
[La] Idioma:eng; spa
[Ab] Resumo:INTRODUCTION: This prospective, observational study evaluated transanal dearterialization (THD) efficacy and safety in grade 2-4 hemorrhoids (HD). METHODS: THD was performed under sedation-locoregional anesthesia in 402 outpatients. Patients had follow-up evaluation 3 days, 2 weeks, 1, 6 and 12 months postoperatively. Postoperative complications and recurrence of symptoms at 12 months were analyzed. The relationship between the learning curve and the number of postoperative complications was studied. RESULTS: Mean patient age was 46.4 (range 20-85) years. A total of 268 patients (66.6%) were male. Sixteen patients (4.0%) had grade 2 HD, 210 (52.2%) had grade 3 and 176 (43.8%) had grade 4 HD. Surgery lasted 23 (17-34) min. A total of 67 patients had complications: bleeding in 10 patients (2.5%), hemorrhoidal thromboses in 10 (2.5%), perianal fistulas in 5 (1.2%), fissures in 14 (3.5%), urinary retention in 3 (0.8%), residual prolapse in 19 (4.7%), severe anal pain in 3 (0.8%), and perianal abscess in 3 patients (0.8%). Recurrent HD occurred in 6.3% (1/16) of grade 2 HD patients, 5.8% (12/210) of grade 3 patients and 9.7% (17/176) of grade 4 patients. Twelve months after THD, bleeding was controlled in 363 patients (90.5%), prolapse was controlled in 391 (97.3%) and pain markedly improved in 390 patients (97%). CONCLUSION: THD appears safe and effective for grade 2-4 HD, and the number of complications decreased with increasing surgeon experience. THD advantages include mild pain, fast recovery, early return to daily activities and low incidence of complications.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Ambulatórios
Hemorroidectomia/métodos
Hemorroidas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Canal Anal
Artérias/cirurgia
Feminino
Hemorroidectomia/efeitos adversos
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171130
[Lr] Data última revisão:
171130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE



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