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[PMID]:28451931
[Au] Autor:Casajoana A; Pujol J; Garcia A; Elvira J; Virgili N; de Oca FJ; Duran X; Fernández-Veledo S; Vendrell J; Vilarrasa N
[Ad] Endereço:Bariatric Surgery Unit, Bellvitge University Hospital-IDIBELL, c/ Feixa Llarga s/n, 08907, Barcelona, L'Hospitalet de Llobregat, Spain.
[Ti] Título:Predictive Value of Gut Peptides in T2D Remission: Randomized Controlled Trial Comparing Metabolic Gastric Bypass, Sleeve Gastrectomy and Greater Curvature Plication.
[So] Source:Obes Surg;27(9):2235-2245, 2017 Sep.
[Is] ISSN:1708-0428
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Our aim was to determine the predictive value of gut hormone changes for the improvement of type 2 diabetes (T2D) following metabolic Roux-en-Y gastric bypass (mRYGB), sleeve gastrectomy (SG), and greater curvature plication (GCP) in a randomized controlled trial. Contradictory results have been obtained regarding the role of gastrointestinal hormones (in particular GLP-1) in beneficial metabolic bariatric surgery outcomes. METHODS: Forty-five patients with T2D (mean BMI 39.4 ± 1.9 kg/m ) were randomly assigned to mRYGB, SG, or GCP. Anthropometric and biochemical parameters, fasting concentrations of PYY, ghrelin, glucagon, and area under the curve (AUC) of GLP-1 after a standard meal test were determined prior to and at months 1 and 12 after surgery. RESULTS: Twelve months after surgery, total weight loss percentage was higher and HbA1c lower in the mRYGB group than in the SG and GCP groups (-35.2 ± 8.1 and 5.1 ± 0.6% vs. -27.8 ± 5.4 and 6.2 ± 0.8% vs. -20.5 ± 6.8 and 6.6 ± 1.3%; p = 0.007 and p < 0.001, respectively). Moreover, GLP-1 AUC at months 1 and 12 was greater and T2D remission was higher in mRYGB (80 vs. 53.3 vs. 20%, p < 0.001). Insulin treatment (odds ratio (OR) 0.025, p = 0.018) and the increase in GLP-1 AUC from baseline to month 1 (OR 1.021, p = 0.013) were associated with T2D remission. CONCLUSIONS: mRYGB achieves a superior rate of weight loss and T2D remission at month 12. Enhanced GLP-1 secretion 1 month after surgery was a determinant of glucose metabolism improvement. Registration number ( http://www.clinicaltrials.gov ): NCT14104758.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/cirurgia
Gastrectomia/métodos
Derivação Gástrica/métodos
Gastroplastia/métodos
[Mh] Termos MeSH secundário: Adulto
Diabetes Mellitus Tipo 2/complicações
Feminino
Hormônios Gastrointestinais/metabolismo
Peptídeo 1 Semelhante ao Glucagon/metabolismo
Seres Humanos
Masculino
Meia-Idade
Obesidade Mórbida/complicações
Obesidade Mórbida/cirurgia
Indução de Remissão
Estômago/cirurgia
Perda de Peso
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Gastrointestinal Hormones); 89750-14-1 (Glucagon-Like Peptide 1)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1007/s11695-017-2669-7


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[PMID]:29458667
[Au] Autor:Atrisco-Morales J; Martínez-Santos VI; Román-Román A; Alarcón-Millán J; De Sampedro-Reyes J; Cruz-Del Carmen I; Martínez-Carrillo DN; Fernández-Tilapa G
[Ad] Endereço:1​Laboratorio de Investigación Clínica, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Av. Lázaro Cárdenas s/n C.U. Sur. Chilpancingo, Guerrero, C.P. 39090, Mexico.
[Ti] Título:vacA s1m1 genotype and cagA EPIYA-ABC pattern are predominant among Helicobacter pylori strains isolated from Mexican patients with chronic gastritis.
[So] Source:J Med Microbiol;67(3):314-324, 2018 Mar.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Virulent genotypes of Helicobacter pylori vacA s1m1/cagA /babA2 have been associated with severe gastric diseases. VacA, CagA and BabA are polymorphic proteins, and their association with the disease is allele-dependent. The aims of this work were: (i) to determine the prevalence of H. pylori by type of chronic gastritis; (ii) to describe the frequency of cagA, babA2 and vacA genotypes in strains from patients with different types of chronic gastritis; (iii) to characterize the variable region of cagA alleles. METHODOLOGY: A total of 164 patients with chronic gastritis were studied. Altogether, 50 H. pylori strains were isolated, and the status of cagA, babA2 and vacA genotypes was examined by PCR. cagA EPIYA segment identification was performed using PCR and sequencing of cagA fragments of six randomly selected strains.Results/Key findings. The overall prevalence of H. pylori was 30.5 %. Eighty percent of the isolated strains were vacA s1m1, and the cagA and babA2 genes were detected in 74 and 32 % of the strains, respectively. The most frequent genotypes were vacA s1m1/cagA /babA2 and vacA s1m1/cagA /babA2 , with 40 % (20/50) and 28 % (14/50), respectively. In cagA , the most frequent EPIYA motif was -ABC (78.4 %), and EPIYA-ABCC and -ABCCC motifs were found in 10.8 % of the strains. A modified EPIYT-B motif was found in 66.6 % of the sequenced strains. CONCLUSION: H. pylori strains carrying vacA s1m1, cagA and babA2 genotypes were the most prevalent in patients with chronic gastritis from the south of Mexico. In the cagA strains, the EPIYA-ABC motif was the most common.
[Mh] Termos MeSH primário: Antígenos de Bactérias/genética
Proteínas de Bactérias/genética
Gastrite/microbiologia
Infecções por Helicobacter/microbiologia
Helicobacter pylori/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Alelos
Doença Crônica/epidemiologia
Feminino
Gastrite/epidemiologia
Gastroscopia
Genótipo
Helicobacter pylori/isolamento & purificação
Seres Humanos
Masculino
México/epidemiologia
Meia-Idade
Reação em Cadeia da Polimerase
Estômago/microbiologia
Estômago/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antigens, Bacterial); 0 (Bacterial Proteins); 0 (VacA protein, Helicobacter pylori); 0 (cagA protein, Helicobacter pylori)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180221
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000660


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[PMID]:29339218
[Au] Autor:Liang J; Dou Y; Wu X; Li H; Wu J; Huang Q; Luo D; Yi T; Liu Y; Su Z; Chen J
[Ad] Endereço:Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
[Ti] Título:Prophylactic efficacy of patchoulene epoxide against ethanol-induced gastric ulcer in rats: Influence on oxidative stress, inflammation and apoptosis.
[So] Source:Chem Biol Interact;283:30-37, 2018 Mar 01.
[Is] ISSN:1872-7786
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Patchoulene epoxide (PAO), a tricyclic sesquiterpene isolated from the long-stored patchouli oil, has been demonstrated the anti-inflammatory activity in vivo based on our previous study. However, the gastric protective effect of PAO still remains unknown. Therefore, in the present study, ethanol-induced gastric ulcer model was carried out to evaluate the anti-ulcerogenic activity of PAO and to elucidate the potential mechanisms that involves. According to our results, macroscopic examination revealed that PAO could significantly reduce ethanol-induced gastric ulcer areas as compared with the vehicle group, which was also supported by the histological evaluation result. As for its potential mechanism, the anti-inflammatory activity of PAO contributed to gastric protection through reversing the imbalance between pro- and anti-inflammatory cytokines and modulating the expressions of NF-κB pathway-related proteins including p-IκBα, IκBα, p-p65 and p65. Besides, PAO was able to enhance the expressions of antioxidant enzymes including glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT), and down-regulate malonaldehyde (MDA), an indicator of lipid peroxidation. Furthermore, immunohistochemistry analysis exhibited potent anti-apoptosis effect of PAO, as evidence by down-regulating the protein expression of caspase-3, Fas and Fasl. Additionally, we also demonstrated that PAO could replenish PGE and NO mucosal defense. In conclusion, these findings suggested that PAO has gastric protective activity against ethanol and this might be related to its influence on inflammatory response, oxidative stress, apoptosis cascade and gastric mucosal defense.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Apoptose/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Sesquiterpenos/farmacologia
Úlcera Gástrica/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/uso terapêutico
Caspase 3/metabolismo
Catalase/metabolismo
Citocinas/análise
Citocinas/metabolismo
Regulação para Baixo/efeitos dos fármacos
Etanol/toxicidade
Inflamação/prevenção & controle
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Óleos Vegetais/química
Pogostemon/química
Pogostemon/metabolismo
Ratos
Ratos Sprague-Dawley
Sesquiterpenos/química
Sesquiterpenos/uso terapêutico
Estômago/patologia
Úlcera Gástrica/induzido quimicamente
Úlcera Gástrica/patologia
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Plant Oils); 0 (Sesquiterpenes); 3K9958V90M (Ethanol); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


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[PMID]:28468689
[Au] Autor:De Silva WSL; Gamlaksha DS; Jayasekara DP; Rajamanthri SD
[Ad] Endereço:Post Graduate Institute of Medicine, University of Colombo, Colombo, Sri Lanka. supun85@gmail.com.
[Ti] Título:A splenic artery aneurysm presenting with multiple episodes of upper gastrointestinal bleeding: a case report.
[So] Source:J Med Case Rep;11(1):123, 2017 May 03.
[Is] ISSN:1752-1947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Splenic artery aneurysm is rare and its diagnosis is challenging due to the nonspecific nature of the clinical presentation. We report a case of a splenic artery aneurysm in which the patient presented with chronic dyspepsia and multiple episodes of minor intragastric bleeding. CASE PRESENTATION: A 60-year-old, previously healthy Sri Lankan man presented with four episodes of hematemesis and severe dyspeptic symptoms over a period of 6 months. The results of two initial upper gastrointestinal endoscopies and an abdominal ultrasound scan were unremarkable. A third upper gastrointestinal endoscopy detected a pulsatile bulge at the posterior wall of the gastric antrum. A contrast-enhanced computed tomogram of his abdomen detected a splenic artery aneurysm measuring 3 × 3 × 2.5 cm. While awaiting routine surgery, he developed a torrential upper gastrointestinal bleeding and shock, leading to emergency laparotomy. Splenectomy and en bloc resection of the aneurysm with the posterior stomach wall were performed. Histology revealed evidence for a true aneurysm without overt, acute, or chronic inflammation of the surrounding gastric mucosa. He became completely asymptomatic 2 weeks after the surgery. CONCLUSIONS: Splenic artery aneurysms can result in recurrent upper gastrointestinal bleeding. The possibility of impending catastrophic bleeding should be remembered when managing patients with splenic artery aneurysms after a minor bleeding. Negative endoscopy and ultrasonography should require contrast-enhanced computed tomography to look for the cause of recurrent upper gastrointestinal bleeding.
[Mh] Termos MeSH primário: Aneurisma Roto/complicações
Hemorragia Gastrointestinal/etiologia
Artéria Esplênica
[Mh] Termos MeSH secundário: Abdome/diagnóstico por imagem
Aneurisma Roto/diagnóstico por imagem
Aneurisma Roto/cirurgia
Endoscopia Gastrointestinal
Seres Humanos
Masculino
Meia-Idade
Esplenectomia
Artéria Esplênica/diagnóstico por imagem
Artéria Esplênica/patologia
Estômago/cirurgia
Tomografia Computadorizada por Raios X
Resultado do Tratamento
Ultrassonografia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1186/s13256-017-1282-7


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[PMID]:29465550
[Au] Autor:Kim SH; Choi YH; Kim JW; Oh S; Lee S; Kim BG; Lee KL
[Ad] Endereço:Department of Internal Medicine.
[Ti] Título:Clinical significance of computed tomography-detected ascites in gastric cancer patients with peritoneal metastases.
[So] Source:Medicine (Baltimore);97(8):e9343, 2018 Feb.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Patients with peritoneal metastases (PM) are generally considered incurable; therefore, the presence of PM is a critical factor in deciding between palliative surgery and curative resection as a therapeutic strategy. Previous studies have not determined the predictive value of ascites detected on computed tomography (CT) for the presence of PM. We aimed to analyze the factors that are associated with PM in patients with CT-detected ascites.A total of 2207 consecutive patients who were diagnosed with gastric cancer between 2004 and 2013 were identified. Eleven patients with liver cirrhosis or chronic renal insufficiency with ascites and 57 patients who received previous treatment were excluded. Ninety-eight patients who had definite evidence of distant metastasis or PM on CT and 64 patients who did not undergo surgery were excluded. A total of 91 patients were enrolled in the study to analyze the association between CT-detected ascites and surgically confirmed PM.Seventy-six patients underwent curative resection and 15 patients underwent palliative surgery. Twelve patients exhibited peritoneal seeding and 37 patients showed regional lymph node metastasis. Regional lymph node metastasis, advanced gastric cancer, undifferentiated pathology, and the amount of ascites were significantly associated with PM. Multivariable logistic regression analysis identified the amount of ascites to be an independent risk factor for the presence of PM.Regional lymph node metastasis, advanced gastric cancer, undifferentiated pathology, and the amount of ascites were associated with PM. The amount of ascites was found to be an independent risk factor for PM.
[Mh] Termos MeSH primário: Ascite/diagnóstico por imagem
Neoplasias Peritoneais/diagnóstico por imagem
Neoplasias Gástricas/diagnóstico por imagem
Estômago/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
[Mh] Termos MeSH secundário: Ascite/etiologia
Feminino
Seres Humanos
Linfonodos/diagnóstico por imagem
Linfonodos/patologia
Metástase Linfática
Masculino
Meia-Idade
Neoplasias Peritoneais/secundário
Peritônio/diagnóstico por imagem
Peritônio/patologia
Estudos Retrospectivos
Estômago/patologia
Neoplasias Gástricas/complicações
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009343


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[PMID]:28458166
[Au] Autor:Melchiades JL; Zabaglia LM; Sallas ML; Orcini WA; Chen E; Smith MAC; Payão SLM; Rasmussen LT
[Ad] Endereço:Universidade do Sagrado Coração (USC), Bauru, São Paulo, Brazil.
[Ti] Título:Polymorphisms and haplotypes of the interleukin 2 gene are associated with an increased risk of gastric cancer. The possible involvement of Helicobacter pylori.
[So] Source:Cytokine;96:203-207, 2017 08.
[Is] ISSN:1096-0023
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Interleukin 2 (IL-2) is a pro-inflammatory cytokine that is mainly synthesized by immunoregulatory T helper cells and which plays an important role in antitumor immunity. Helicobacter pylori (H. pylori) is a gram-negative bacterium that colonizes the gastric mucosa and induces the production of IL-2. This process increases the magnitude of inflammation and may influence the development of gastric pathologies. In light of the possible involvement of IL-2 and the presence of H. pylori in gastric diseases, this study investigated possible associations between the IL-2 polymorphisms +114 T>G (rs2069763) and -330 T>G (rs2069762) and the development of gastric cancer; these associations were then correlated with the presence of H. pylori. Gastric biopsies were obtained from 294 dyspeptic patients (173♀/123♂). Of these samples, 181 were chronic gastritis samples (102♀/79), 62 were samples of intact gastric mucosa (47♀/15♂), and 51 were samples of gastric cancer (22♀/29♂). PCR-RFLP was used to characterize the +114 T>G and -330 T>G polymorphisms. Considering the genetic characteristics of the study population and based on the codominant model, a high risk of gastric cancer among patients with normal gastric tissue and patients with gastric cancer was found in subjects with the IL-2-330 GG genotype (OR=6.43, 95% CI: 1.47-28.10, p=0.044). The data was adjusted for the presence of H. pylori. Among patients with gastritis and patients with gastric cancer, a high risk was found among subjects with the IL-2-330 GG genotype (OR=4.47, 95% CI: 1.84-10.84, p=0.0022). When the IL-2 +114 polymorphism was analyzed, similar results were found. Among the patients with normal gastric tissue and the patients with gastric cancer, subjects carrying the +114 TT genotype were found to be at a high risk of gastric cancer (OR=5.97, 95% CI: 1.60-22.27, p=0.013). This data was also adjusted for the presence of H. pylori. Among patients with gastritis and patients with gastric cancer, a high risk was found in subjects carrying the +114 TT genotype (OR=6.36, 95% CI: 2.66-15.21, p<0.0001). The haplotype was also analyzed. The -330G/+114T haplotype was found to be significantly associated with gastric cancer. Therefore, our results show that, among patients with H. pylori infection, the -330 GG and +114 TT genotypes are significantly associated with a high risk of developing gastric cancer, as is the -330G/+114T haplotype.
[Mh] Termos MeSH primário: Infecções por Helicobacter/complicações
Interleucina-2/genética
Polimorfismo de Nucleotídeo Único
Neoplasias Gástricas/genética
[Mh] Termos MeSH secundário: Adulto
Idoso
Grupo com Ancestrais do Continente Asiático
Biópsia
Feminino
Gastrite/microbiologia
Estudos de Associação Genética
Predisposição Genética para Doença
Genótipo
Haplótipos
Infecções por Helicobacter/imunologia
Helicobacter pylori/isolamento & purificação
Seres Humanos
Masculino
Meia-Idade
Polimorfismo de Fragmento de Restrição
Estômago/patologia
Neoplasias Gástricas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-2)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170502
[St] Status:MEDLINE


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[PMID]:28455456
[Au] Autor:Inayat F; Ullah W; Hussain Q; Shafique K
[Ad] Endereço:New York-Presbyterian Hospital, Weill Cornell Medical College, New York City, New York, USA.
[Ti] Título:Crohn's disease presenting as gastric outlet obstruction: a therapeutic challenge?
[So] Source:BMJ Case Rep;2017, 2017 Apr 28.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Isolated gastric Crohn's disease with initial presentation related to gastric outlet obstruction is an unusual clinicopathological entity. We undertake here a literature review of this rare initial presentation of isolated gastric Crohn's disease and discuss the formidable diagnostic and therapeutic challenges encountered in such patients.
[Mh] Termos MeSH primário: Doença de Crohn/complicações
Doença de Crohn/patologia
Obstrução da Saída Gástrica/complicações
Obstrução da Saída Gástrica/patologia
[Mh] Termos MeSH secundário: Adulto
Doença de Crohn/diagnóstico
Endoscopia do Sistema Digestório/métodos
Endoscopia Gastrointestinal/métodos
Feminino
Obstrução da Saída Gástrica/diagnóstico por imagem
Gastrite/diagnóstico
Gastrite/etiologia
Seres Humanos
Estômago/patologia
Gastropatias/patologia
Tomografia Computadorizada por Raios X/métodos
Resultado do Tratamento
Perda de Peso
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE


  8 / 45219 MEDLINE  
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[PMID]:28595197
[Au] Autor:Shan J; Lei H; Shi W; Sun X; Tang Y; Ren C
[Ad] Endereço:Department of Gastroenterology, The 3rd People's Hospital of Chengdu, The Second Affiliated Hospital of Chengdu, Chongqing Medical University, Chengdu, China.
[Ti] Título:High Serum Pepsinogen I and beta Helicobacter pylori Infection Are Risk Factors for Aspirin-Induced Gastroduodenal Injury.
[So] Source:Dig Dis;36(1):66-71, 2018.
[Is] ISSN:1421-9875
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Whether gastric hyperchlorhydria and Helicobacter pylori infection contribute to aspirin-induced gastroduodenal injury still lacks evidence. Because serum pepsinogens (PGs) and gastrin-17 (G17) can reflect gastric acid secretion, this study intended to elucidate whether serum PGs, serum G17, and H. pylori infection are associated with aspirin-induced gastrointestinal injury. SUMMARY: A total of 60 patients taking low-dose aspirin for more than 1 month were enrolled in this study. Serum PG I, PG II, and G17 were determined using ELISA. A 14C-urea breath test was used for the detection of an H. pylori infection. The modified Lanza score was used to evaluate the degree of gastroduodenal injury under endoscopy. The median serum PG I level was significantly higher in the intensive gastroduodenal injury (IGI) group compared to that in the mild gastroduodenal injury group (155.0 vs. 116.6 ng/mL, p = 0.006). The H. pylori infection rate was significantly higher in the IGI group (73 vs. 40%, p = 0.037). Receiver operator characteristic curves analysis revealed that the cutoff value of PG I was 123 ng/mL, with 80% sensitivity and 61.4% specificity. H. pylori infection combined with PG I at >123 ng/mL had an OR (95% CI) of 15.8 (2.4 ± 104.5) for the prediction of aspirin-induced gastroduodenal injury. Key Messages: Serum PG I and H. pylori infection could be used to identify potential high-risk aspirin-induced gastroduodenal injury patients.
[Mh] Termos MeSH primário: Aspirina/efeitos adversos
Duodeno/lesões
Infecções por Helicobacter/sangue
Infecções por Helicobacter/microbiologia
Helicobacter pylori/fisiologia
Pepsinogênio A/sangue
Estômago/lesões
[Mh] Termos MeSH secundário: Idoso
Área Sob a Curva
Duodeno/efeitos dos fármacos
Feminino
Gastrinas/sangue
Infecções por Helicobacter/complicações
Seres Humanos
Masculino
Meia-Idade
Análise Multivariada
Curva ROC
Fatores de Risco
Estômago/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gastrins); 60748-06-3 (gastrin 17); 9001-10-9 (Pepsinogen A); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170609
[St] Status:MEDLINE
[do] DOI:10.1159/000477203


  9 / 45219 MEDLINE  
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[PMID]:29317209
[Au] Autor:Gong Y; Zhu Y; Zhu B; Si X; Heng D; Tang Y; Sun X; Lin L
[Ad] Endereço:Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
[Ti] Título:LncRNA MALAT1 is up-regulated in diabetic gastroparesis and involved in high-glucose-induced cellular processes in human gastric smooth muscle cells.
[So] Source:Biochem Biophys Res Commun;496(2):401-406, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent years, widespread long non-coding RNAs (lncRNAs) were identified and known as regulator of gene expression. Diabetic gastroparesis (DGP) is one of the most common chronic complications of diabetes mellitus. There was no research reported the role of lncRNAs in DGP. In this study, we firstly established a rat model of DGP by STZ injection. Then, we detected the expression of MALAT1 and found that expression of MALAT1 was up-regulated in rat model of DGP, comparing to the control group (P < .01). Furthermore, we revealed that MALAT1 expression was increased in the samples from diabetic patients with DGP symptoms, in comparison with the control. In addition, we demonstrated that the inhibition of MALAT1 increased the expression of α-SMA and SM myosin heavy chains, reduced the cell viability, inhibited the potential of cell migration and induced cell apoptosis in human gastric smooth muscle cells (SMCs). Ultimately, we found that the regulation of MALAT1 expression modulated the function of high-glucose stimulation in human gastric SMCs. Therefore, our study firstly indicated that MALAT1 was up-regulated in DGP and played an important role in the pathogenesis of DGP.
[Mh] Termos MeSH primário: Diabetes Mellitus Experimental/genética
Neuropatias Diabéticas/genética
Gastroparesia/genética
Miócitos de Músculo Liso/metabolismo
RNA Longo não Codificante/genética
Estômago/metabolismo
[Mh] Termos MeSH secundário: Actinas/genética
Actinas/metabolismo
Animais
Apoptose/efeitos dos fármacos
Apoptose/genética
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Diabetes Mellitus Experimental/induzido quimicamente
Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Experimental/metabolismo
Neuropatias Diabéticas/induzido quimicamente
Neuropatias Diabéticas/complicações
Neuropatias Diabéticas/metabolismo
Esvaziamento Gástrico
Gastroparesia/induzido quimicamente
Gastroparesia/complicações
Gastroparesia/metabolismo
Regulação da Expressão Gênica
Glucose/farmacologia
Seres Humanos
Masculino
Miócitos de Músculo Liso/efeitos dos fármacos
Miócitos de Músculo Liso/patologia
Cadeias Pesadas de Miosina/genética
Cadeias Pesadas de Miosina/metabolismo
Cultura Primária de Células
RNA Longo não Codificante/metabolismo
Ratos
Ratos Sprague-Dawley
Transdução de Sinais
Estômago/efeitos dos fármacos
Estômago/patologia
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ACTA2 protein, human); 0 (Actins); 0 (MALAT1 long non-coding RNA, human); 0 (RNA, Long Noncoding); 5W494URQ81 (Streptozocin); EC 3.6.4.1 (Myosin Heavy Chains); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:29304153
[Au] Autor:Barszcz M; Taciak M; Tusnio A; Skomial J
[Ad] Endereço:Department of Animal Nutrition, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Jablonna, Poland.
[Ti] Título:Effects of dietary level of tannic acid and protein on internal organ weights and biochemical blood parameters of rats.
[So] Source:PLoS One;13(1):e0190769, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tannic acid (TA) is a polyphenolic compound with a health-promoting potential for humans. It is hypothesised that TA effects on the relative weight of internal organs and biochemical blood indices are modified by dietary protein level in rats. The study involved 72 rats divided into 12 groups fed diets with 10 or 18% of crude protein (CP) and supplemented with 0, 0.25, 0.5, 1, 1.5 or 2% of TA. After 3 weeks of feeding, the relative weight of the caecum was greater in rats fed TA diets, while feeding diets with 10% of CP increased the relative weight of the stomach, small intestine and caecum, but decreased that of kidneys and spleen. Albumin concentration was higher in rats fed 0.25% and 0.5% TA diets than in rats given the 2% TA diets. The 2% TA diets reduced creatine kinase (CK) activity compared to non-supplemented diets and those with 0.5, 1 and 1.5% of TA. Rats fed the 10% CP diets had a higher activity of alkaline phosphatase, amylase, and γ-glutamyltransferase as well as the concentration of iron and cholesterol, but lower that of urea and uric acid. The interaction affected only cholinesterase activity. In conclusion, TA induced caecal hypertrophy and could act as a cardioprotective agent, as demonstrated by reduced CK activity, but these effects were not modified by dietary protein level.
[Mh] Termos MeSH primário: Dieta
Proteínas na Dieta
Taninos
[Mh] Termos MeSH secundário: Animais
Ceco/anatomia & histologia
Colesterol/sangue
Colinesterases/sangue
Creatina Quinase/sangue
Intestino Delgado/anatomia & histologia
Rim/anatomia & histologia
Masculino
Tamanho do Órgão
Ratos Endogâmicos WF
Albumina Sérica
Baço/anatomia & histologia
Estômago/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Dietary Proteins); 0 (Serum Albumin); 0 (Tannins); 97C5T2UQ7J (Cholesterol); EC 2.7.3.2 (Creatine Kinase); EC 3.1.1.8 (Cholinesterases)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190769



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