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[PMID]:29369206
[Au] Autor:Niu R; Wang JF; Zhang DC; Shao XL; Qiu C; Wang YT
[Ad] Endereço:Department of Nuclear Medicine.
[Ti] Título:Low-grade myofibroblastic sarcoma of gastric cardia on 18F-FDG positron emission tomography/computed tomography: An extremely rare case report.
[So] Source:Medicine (Baltimore);97(4):e9720, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Low-grade myofibroblastic sarcoma (LGMS) is a rare mesenchyme-derived tumor, which usually occurs in head, neck (especially tongue and mouth), and limbs. In this report, we described a case of gastric LGMS by F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), which has not been reported previously. PATIENT CONCERNS: A 51-year-old female patient was admitted to our hospital with upper abdominal discomfort for 1 year and gradually increased eating difficulties over the last 3 months. From gastroscopy, an ulcer of 1.0 cm × 1.2 cm at the entrance of cardia and stiffness of peripheral mucosa were found, leading to suspicion of cardia cancer. F-FDG PET/CT was performed for further diagnosis and staging. DIAGNOSES: According to pathological findings in combination with immunohistochemical features, diagnosis of gastric LGMS was made. INTERVENTIONS: To relieve symptoms of upper gastrointestinal obstruction in the patient, proximal gastrectomy was carried out 1 week after the F-FDG PET/CT scan. OUTCOMES: The patient died due to advanced tumor. LESSONS: F-FDG PET/CT scan showed local thickening of the gastric wall, invasion of adjacent soft tissue, diaphragmatic and peritoneal metastasis at early stage, absence of regional lymph node metastasis, and increased F-FDG metabolism in primary tumor and metastatic tumor.
[Mh] Termos MeSH primário: Cárdia/diagnóstico por imagem
Fluordesoxiglucose F18
Miossarcoma/diagnóstico por imagem
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons/métodos
Compostos Radiofarmacêuticos
Neoplasias Gástricas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Cárdia/patologia
Feminino
Seres Humanos
Meia-Idade
Miossarcoma/patologia
Gradação de Tumores
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009720


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[PMID]:28375471
[Au] Autor:Mao XL; Ye LP; Zheng HH; Zhou XB; Zhu LH; Zhang Y
[Ad] Endereço:Department of Gastroenterology, Taizhou Hospital of Zhejiang Province, Wenzhou Medical College, Linhai, Zhejiang Province, China.
[Ti] Título:Submucosal tunneling endoscopic resection using methylene-blue guidance for cardial subepithelial tumors originating from the muscularis propria layer.
[So] Source:Dis Esophagus;30(4):1-7, 2017 Apr 01.
[Is] ISSN:1442-2050
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Submucosal tunneling endoscopic resection (STER) of subepithelial tumors (SETs) originating from the muscularis propria (MP) layer in the cardia is rarely performed due to the difficulty of creating a submucosal tunnel for resection. The aim of this study is to evaluate the feasibility of STER using methylene-blue guidance for SETs originating from the MP layer in the cardia. From January 2012 to December 2014, 56 patients with SETs originating from the MP layer in the cardia were treated with STER using methylene-blue guidance. The complete resection rate and adverse event rate were the main outcome measurements. Successful complete resection by STER was achieved in all 56 cases (100%). The median size of the tumor was 1.8 cm. Nine patients (15.3%) had adverse events including subcutaneous emphysema, pneumoperitoneum, pneumothorax, and pleural effusion. These nine patients recovered successfully after conservative treatment without endoscopic or surgical intervention. No residual or recurrent tumors were detected in any patient during the follow-up period (median, 25 months). The adverse event rate was significantly higher for tumors originating in the deeper MP layers (46.7%) than in the superficial MP layers (4.9%) (P < 0.05), differed significantly according to tumor size (5.4% for tumors < 2.0 cm vs. 36.8% for tumors ≥ 2.0 cm; P < 0.05), and also differed significantly in relation to the tumor growth pattern (4.1% for the intraluminal growth vs. 100% for the extraluminal growth; P < 0.001). STER using methylene-blue guidance appears to be a feasible method for removing SETs originating from the MP layer in the cardia.
[Mh] Termos MeSH primário: Cárdia/cirurgia
Mucosa Gástrica/cirurgia
Gastroscopia/métodos
Azul de Metileno
Neoplasias Gástricas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Estudos de Viabilidade
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Nm] Nome de substância:
T42P99266K (Methylene Blue)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1093/dote/dow023


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[PMID]:28375449
[Au] Autor:Zhang H; Chen L; Geng Y; Zheng Y; Wang Y
[Ti] Título:Modified anastomotic technique for thoracolaparoscopic Ivor-Lewis esophagectomy: early outcomes and technical details.
[So] Source:Dis Esophagus;30(5):1-5, 2017 May 01.
[Is] ISSN:1442-2050
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Thoracoscopic intrathoracic esophagogastrostomy is a technically demanding operation; these technical requirements restrict the extensive application of minimally invasive Ivor-Lewis esophagectomy. In an attempt to reduce the difficulty of this surgical procedure, this study developed a modified anastomotic technique for thoracolaparoscopic Ivor-Lewis esophagectomy. During the entirety of this modified approach, neither technically challenging operations such as intrathoracic suturing or knotting, nor special instruments such as an OrVil system or a reverse-puncture head are required. Between October 2015 and January 2016, 15 consecutive patients with cancer in the distal third of the esophagus or the gastric cardia underwent this modified surgical procedure. The good short-term outcomes that were achieved suggest that the modified anastomotic technique is safe and feasible for thoracolaparoscopic Ivor-Lewis esophagectomy.
[Mh] Termos MeSH primário: Neoplasias Esofágicas/cirurgia
Esofagectomia/métodos
Esôfago/cirurgia
Laparoscopia/métodos
Toracoscopia/métodos
[Mh] Termos MeSH secundário: Anastomose Cirúrgica/métodos
Cárdia/cirurgia
Feminino
Seres Humanos
Masculino
Neoplasias Gástricas/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1093/dote/dow021


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[PMID]:28345805
[Au] Autor:Guo W; Dong Z; Liu S; Qiao Y; Kuang G; Guo Y; Shen S; Liang J
[Ad] Endereço:Laboratory of Pathology, Hebei Cancer Institute, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
[Ti] Título:Promoter hypermethylation-mediated downregulation of miR-770 and its host gene MEG3, a long non-coding RNA, in the development of gastric cardia adenocarcinoma.
[So] Source:Mol Carcinog;56(8):1924-1934, 2017 Aug.
[Is] ISSN:1098-2744
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Maternally expressed gene 3 (MEG3) is an imprinted gene located at 14q32 which encodes an lncRNA and is downregulated in an expanding list of cancer cell lines and primary human cancers. The miR-770 is transcribed from the intronic sequence of MEG3 and MEG3 may be the host gene for miR-770. However, the biological role of MEG3 and miR-770 in gastric cardia adenocarcinoma (GCA) development and prognosis is poorly defined. The present study was to investigate the function and methylation status of MEG3 in GCA, and further to detect the functional association of miR-770 and its host gene MEG3 in GCA carcinogenesis and prognosis. MEG3 and miR-770 was significantly downregulated in GCA patients and cell lines, and their expression was associated with TNM stage and lymph node metastasis. Overexpression of MEG3 and miR-770 inhibited gastric cancer cell proliferation and invasion in vitro. Furthermore, the expression level of MEG3 and miR-770 was significantly increased in cancer cells after treated with 5-Aza-dC. The aberrant hypermethylation of proximal promoter and enhancer region of MEG3 was detected in GCA tissues. In addition, the proximal promoter and enhancer region hypermethylation and dysregulation of MEG3 and miR-770 were associated with poorer GCA patients' survival. These findings suggest that miR-770 and its host gene MEG3 may play tumor suppressor role and hypermethylation of proximal promoter and enhancer region may be one of the critical mechanisms in inactivation of MEG3 and miR-770 in GCA development. MEG3 and miR-770 may be used as potential biomarkers in predicting GCA patients' prognosis.
[Mh] Termos MeSH primário: Adenocarcinoma/genética
Cárdia/patologia
Metilação de DNA
Regulação Neoplásica da Expressão Gênica
MicroRNAs/genética
RNA Longo não Codificante/genética
Neoplasias Gástricas/genética
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adulto
Idoso
Sequência de Bases
Cárdia/metabolismo
Regulação para Baixo
Epigênese Genética
Feminino
Seres Humanos
Masculino
Meia-Idade
Invasividade Neoplásica/genética
Invasividade Neoplásica/patologia
Regiões Promotoras Genéticas
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MEG3 non-coding RNA, human); 0 (MIRN-770 microRNA, human); 0 (MicroRNAs); 0 (RNA, Long Noncoding)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1002/mc.22650


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[PMID]:28325198
[Au] Autor:Gomez G
[Ad] Endereço:General Surgery, The University of Texas Medical Branch, Galveston, TX, USA. Electronic address: ggomez@utmb.edu.
[Ti] Título:The Evaluation and Management of Suspicious Gastric Lesions Following Bariatric Surgery.
[So] Source:Surg Clin North Am;97(2):467-474, 2017 Apr.
[Is] ISSN:1558-3171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity has reached epidemic proportions worldwide and is associated with a higher mortality from several diseases, including adenocarcinoma of the esophagus and of the gastric cardia. Increased body mass index is associated with an increased incidence of gastroesophageal reflux disease (GERD), Barrett metaplasia, and adenocarcinoma of the cardia. Bariatric surgery remains the most effective therapy for morbid obesity and has the potential to improve weight-related GERD. A high index of suspicion is paramount for early detection of foregut neoplasia after bariatric surgery.
[Mh] Termos MeSH primário: Cirurgia Bariátrica
Obesidade Mórbida/cirurgia
Complicações Pós-Operatórias/etiologia
[Mh] Termos MeSH secundário: Adenocarcinoma/diagnóstico
Adenocarcinoma/etiologia
Esôfago de Barrett/diagnóstico
Esôfago de Barrett/etiologia
Cárdia/cirurgia
Neoplasias Esofágicas/diagnóstico
Neoplasias Esofágicas/etiologia
Feminino
Refluxo Gastroesofágico/diagnóstico
Refluxo Gastroesofágico/etiologia
Seres Humanos
Achados Incidentais
Masculino
Obesidade Mórbida/complicações
Complicações Pós-Operatórias/diagnóstico
Neoplasias Gástricas/diagnóstico
Neoplasias Gástricas/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170323
[St] Status:MEDLINE


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[PMID]:28319273
[Au] Autor:Yu G; Hu N; Wang L; Wang C; Han XY; Humphry M; Ravel J; Abnet CC; Taylor PR; Goldstein AM
[Ad] Endereço:Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD.
[Ti] Título:Gastric microbiota features associated with cancer risk factors and clinical outcomes: A pilot study in gastric cardia cancer patients from Shanxi, China.
[So] Source:Int J Cancer;141(1):45-51, 2017 Jul 01.
[Is] ISSN:1097-0215
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Little is known about the link between gastric microbiota and the epidemiology of gastric cancer. In order to determine the epidemiologic and clinical relevance of gastric microbiota, we used 16 S ribosomal RNA gene sequencing analysis to characterize the composition and structure of the gastric microbial community of 80 paired samples (non-malignant and matched tumor tissues) from gastric cardia adenocarcinoma (GCA) patients in Shanxi, China. We also used PICRUSt to predict microbial functional profiles. Compared to patients without family history of upper gastrointestinal (UGI) cancer in the non-malignant gastric tissue microbiota, patients with family history of UGI cancer had higher Helicobacter pylori (Hp) relative abundance (median: 0.83 vs. 0.38, p = 0.01) and lower alpha diversity (median observed species: 51 vs. 85, p = 0.01). Patients with higher (vs. lower) tumor grade had higher Hp relative abundance (0.73 vs. 0.18, p = 0.03), lower alpha diversity (observed species, 66 vs. 89, p = 0.01), altered beta diversity (weighted UniFrac, p = 0.002) and significant alterations in relative abundance of five KEGG functional modules in non-malignant gastric tissue microbiota. Patients without metastases had higher relative abundance of Lactobacillales than patients with metastases (0.05 vs. 0.01, p = 0.04) in non-malignant gastric tissue microbiota. These associations were observed in non-malignant tissues but not in tumor tissues. In conclusion, this study showed a link of gastric microbiota to a major gastric cancer risk factor and clinical features in GCA patients from Shanxi, China. Studies with both healthy controls and gastric cardia and noncardia cancer cases across different populations are needed to further examine the association between gastric cancer and the microbiota.
[Mh] Termos MeSH primário: Adenocarcinoma/microbiologia
Bactérias/genética
Microbioma Gastrointestinal/genética
Neoplasias Gástricas/microbiologia
[Mh] Termos MeSH secundário: Adenocarcinoma/genética
Adenocarcinoma/patologia
Bactérias/classificação
Bactérias/patogenicidade
Cárdia/microbiologia
Cárdia/patologia
China
Helicobacter pylori/genética
Helicobacter pylori/patogenicidade
Seres Humanos
RNA Ribossômico 16S/genética
Fatores de Risco
Neoplasias Gástricas/genética
Neoplasias Gástricas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1002/ijc.30700


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[PMID]:28303873
[Au] Autor:Moiseev AY; Shulutko AM; Gryaznov SE
[Ad] Endereço:Chair of Faculty Surgery #2, Sechenov First Moscow State Medical University.
[Ti] Título:[Transhiatal esophagectomy for cardia and esophagus cancer].
[Ti] Título:Transkhiatal'naya ezofagektomiya pri rake kardii i pishchevoda..
[So] Source:Khirurgiia (Mosk);(2):51-53, 2017.
[Is] ISSN:0023-1207
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:AIM: To present the result of transhiatal esophagectomies with simultaneous repair. MATERIAL AND METHODS: The study included 67 procedures. In 35 cases surgery was carried out for adenocarcinoma of distal esophagus or cardia with high transition to esophagus, in 32 cases - for epidermal carcinoma of the esophagus. Gastric graft and left half of the colon were used in 60 and 7 cases respectively for simultaneous repair. 29 patients underwent transhiatal instrumental esophagectomy using author's original technique.
[Mh] Termos MeSH primário: Carcinoma
Neoplasias Esofágicas
Esofagectomia
Laparotomia
Complicações Pós-Operatórias
Neoplasias Gástricas
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma/patologia
Carcinoma/cirurgia
Cárdia/diagnóstico por imagem
Cárdia/cirurgia
Neoplasias Esofágicas/patologia
Neoplasias Esofágicas/cirurgia
Esofagectomia/efeitos adversos
Esofagectomia/métodos
Junção Esofagogástrica/diagnóstico por imagem
Junção Esofagogástrica/cirurgia
Esôfago/diagnóstico por imagem
Esôfago/cirurgia
Feminino
Seres Humanos
Cuidados Intraoperatórios/métodos
Laparotomia/efeitos adversos
Laparotomia/métodos
Masculino
Meia-Idade
Avaliação de Processos e Resultados (Cuidados de Saúde)
Complicações Pós-Operatórias/diagnóstico
Complicações Pós-Operatórias/etiologia
Complicações Pós-Operatórias/prevenção & controle
Neoplasias Gástricas/patologia
Neoplasias Gástricas/cirurgia
Análise de Sobrevida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170318
[St] Status:MEDLINE
[do] DOI:10.17116/hirurgia2017251-53


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[PMID]:28293089
[Au] Autor:Qiao YF; Chen CG; Yue J; Ma MQ; Ma Z; Yu ZT
[Ad] Endereço:Yu-Feng Qiao, Chuan-Gui Chen, Jie Yue, Ming-Quan Ma, Zhao Ma, Zhen-Tao Yu, Department of Esophageal Cancer, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy of Tianjin City, Tianjin 300060, China.
[Ti] Título:Prognostic significance of preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of patients with gastric cardia cancer.
[So] Source:World J Gastroenterol;23(8):1424-1433, 2017 Feb 28.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: To evaluate the clinical and prognostic significance of preoperative and postoperative cytokeratin 19 (CK19) and carcinoembryonic antigen (CEA) mRNA levels in peripheral blood of patients with gastric cardia cancer (GCC). METHODS: We detected the preoperative and postoperative mRNA levels of CK19 and CEA in peripheral blood of 129 GCC patients by using reverse transcription-polymerase chain reaction and evaluated their clinical and prognostic significance by univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard analysis. A new prognostic model which stratified patients into three different risk groups was established based on the independent prognostic factors. RESULTS: Elevated preoperative and postoperative CK19 and CEA mRNA levels in peripheral blood of GCC patients were associated with lymph node metastasis. Univariate analysis showed that tumor size, histological grade, depth of tumor invasion, lymph node metastasis, preoperative CK19 mRNA, and preoperative and postoperative CEA mRNA levels were correlated with the prognosis of GCC patients. The multivariate analysis showed that lymph node status ( = 0.018), preoperative CK19 ( = 0.035) and CEA ( = 0.011) mRNA levels were independent prognostic factors for overall survival (OS). The 5-year OS rates for the low-, intermediate-, and high-risk groups were 48.3%, 22.6%, and 4.6%, respectively ( < 0.001). CONCLUSION: Elevated preoperative CK19 and CEA mRNA levels may be regarded as promising biomarkers for predicting lymph node metastasis and poor prognosis in patients with GCC. This new prognostic model may help us identify the subpopulations of GCC patients with the highest risk.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/sangue
Antígeno Carcinoembrionário/sangue
Cárdia/patologia
Queratina-19/sangue
Neoplasias Gástricas/sangue
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seguimentos
Regulação Neoplásica da Expressão Gênica
Seres Humanos
Estimativa de Kaplan-Meier
Metástase Linfática
Masculino
Meia-Idade
Análise Multivariada
Prognóstico
Modelos de Riscos Proporcionais
RNA Mensageiro/metabolismo
Curva ROC
Estudos Retrospectivos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (Carcinoembryonic Antigen); 0 (Keratin-19); 0 (RNA, Messenger)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170316
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v23.i8.1424


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[PMID]:28196067
[Au] Autor:Petrick JL; Kelly SP; Liao LM; Freedman ND; Graubard BI; Cook MB
[Ad] Endereço:Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA.
[Ti] Título:Body weight trajectories and risk of oesophageal and gastric cardia adenocarcinomas: a pooled analysis of NIH-AARP and PLCO Studies.
[So] Source:Br J Cancer;116(7):951-959, 2017 Mar 28.
[Is] ISSN:1532-1827
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Elevated body mass index (BMI, kg m ) has been consistently associated with oesophageal adenocarcinoma (EA) and gastric cardia adenocarcinoma (GCA) incidence. However, effects of adiposity over the life course in relation to EA/GCA have not been thoroughly explored. METHODS: We pooled two prospective cohort studies: NIH-AARP Diet and Health Study and Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, with data on 409 796 individuals (633 EA, 415 GCA). At baseline, participants reported their height and weight at ages 20 and 50 years, and current. Body mass index trajectories were determined using latent class analysis. Hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using proportional hazards regression. RESULTS: Compared with individuals with a BMI<25 kg m at all time points, exceeding a BMI of 25 kg m at age 20 was associated with increased risks of EA (HR=1.76, 95% CI: 1.35-2.29) and GCA (HR=1.62, 95% CI: 1.16-2.25). Similarly, a BMI trajectory of overweight (⩾25-<30 kg m ) at age 20 progressing to obesity (⩾30 kg m ) by age 50 was associated with increased risks of EA (HR=2.90, 95% CI: 1.67-5.04) and GCA (HR=4.07, 95% CI: 2.32-7.15), compared with individuals with a normal weight (⩾18.5-<25 kg m ) trajectory. Weight gain of ⩾20 kg between age 20 and baseline was also associated with a two times increased risk of EA (HR=1.97, 95% CI: 1.43-2.73) and more modestly with GCA (HR=1.40, 95% CI: 0.96-2.05). CONCLUSIONS: Being overweight in early adulthood and weight gain later in life were each associated with increased risks of EA and GCA. This underscores the potential of weight control programs for reducing EA and GCA risk.
[Mh] Termos MeSH primário: Adenocarcinoma/etiologia
Cárdia/patologia
Dieta/efeitos adversos
Neoplasias Esofágicas/etiologia
Obesidade/complicações
Sobrepeso/complicações
Neoplasias Gástricas/etiologia
[Mh] Termos MeSH secundário: Adenocarcinoma/patologia
Adulto
Índice de Massa Corporal
Neoplasias Esofágicas/patologia
Feminino
Seguimentos
Seres Humanos
Incidência
Masculino
Meia-Idade
Estadiamento de Neoplasias
Prognóstico
Estudos Prospectivos
Fatores de Risco
Neoplasias Gástricas/patologia
Ganho de Peso
Adulto Jovem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170525
[Lr] Data última revisão:
170525
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1038/bjc.2017.29


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[PMID]:28067081
[Au] Autor:Balázs Á; Winkler B; Kristóf K; Harsányi L; Bokor L
[Ad] Endereço:Általános Orvostudományi Kar, I. Sebészeti Klinika, Semmelweis Egyetem Budapest, Ülloi út 78., 1082.
[Ti] Título:[Relationship of consequences of anastomotic insufficiency and bacterial flora of oral cavity in patients with esophageal and cardia cancer].
[Ti] Título:A szájüreg baktériumflórájának összefüggése az anastomosiselégtelenség következményeivel nyelocso- és cardiatumoros betegeknél..
[So] Source:Orv Hetil;158(1):25-30, 2017 Jan.
[Is] ISSN:0030-6002
[Cp] País de publicação:Hungary
[La] Idioma:hun
[Ab] Resumo:INTRODUCTION: In the course of anastomotic insufficiency following resection of esophageal cancers the bacterial compound of the esophageal substance has a remarkable, presumable role in the outcome of complications. AIM: The purpose of this study is to compare the consequences of the anastomotic leak with the bacterial flora of patients' oral cavity. METHOD: In this prospective study a total of 131 patients were investigated directly before the surgical intervention taking a bacterial sample. Bacterial flora of patients' oral cavity was analysed; and the correlation between the consequences of the anastomotic leak and the content of the bacterial flora was examined. RESULTS: Pathogenic bacteria in the oral microflora in 50 cases (38.2%) was found. Statistically significant, moderate correlation was found between the severity of the complication and the incidence of pathogenic bacteria (r = 0.553; p≤0.05). CONCLUSIONS: Pathogenic agent in the microbial flora might induce higher risk and more severe outcome in case of anastomotic leakage and it might be evaluated as a determinative factor. Consideration of the bacterial flora of the oral cavity requires more attention in the preoperative preparation than before and it demands the change of the current practice. Orv. Hetil., 2017, 158(1), 25-30.
[Mh] Termos MeSH primário: Fístula Anastomótica/microbiologia
Cárdia/microbiologia
Neoplasias Esofágicas/microbiologia
Esofagectomia/efeitos adversos
Neoplasias Gástricas/microbiologia
[Mh] Termos MeSH secundário: Anastomose Cirúrgica/efeitos adversos
Cárdia/cirurgia
Neoplasias Esofágicas/cirurgia
Seres Humanos
Estudos Prospectivos
Neoplasias Gástricas/cirurgia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE
[do] DOI:10.1556/650.2017.30632



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