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[PMID]:29310440
[Au] Autor:Kodama H; Kumai Y; Nishimoto K; Toya Y; Miyamaru S; Furushima S; Yumoto E
[Ad] Endereço:1 Department of Otolaryngology Head and Neck Surgery, Kumamoto University Graduate School of Medicine, Kumamoto, Japan.
[Ti] Título:The Ferret as a Surgical Model for Vocal Fold Scar Creation and Treatment.
[So] Source:Ann Otol Rhinol Laryngol;127(3):146-154, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To develop a vocal fold (VF) scarring procedure in the ferret, characterize the scars histologically, and test the injectability of the lamina propria (LP). Secondarily, to compare laryngeal anatomy of the ferret with rat and rabbit. MATERIALS AND METHODS: The larynges of 18 male ferrets were prepared by unilateral scarring, and normal larynges from 6 female Wistar rats and 5 male albino rabbits were used for comparative purposes. For scarring, the right VF were electrocauterized, ablating the entire LP. Prior to harvesting the larynges at 4 and 16 weeks, each ferret was re-anesthetized, and in 3 animals, India ink was injected into the LPs of both normal and scarred VFs. RESULTS: Laryngoscopic methods and instrumentation for precise visualization, scarring, and injection were developed. The scarred VFs had reduced hyaluronic acid and increased collagen type I, III, and fibronectin compared with normal VFs. The 2 timepoints (4 and 16 weeks) differed significantly only in collagen type III level (levels were higher at 4 weeks). Injected ink migrated from scarred LP to muscle layer just beneath the scarred tissue 3 hours after injection. CONCLUSION: The ferret is a promising species for creation and experimental treatment of vocal fold scar.
[Mh] Termos MeSH primário: Cicatriz
Eletrocoagulação/métodos
Laringoscopia
Membrana Mucosa
Prega Vocal/cirurgia
[Mh] Termos MeSH secundário: Animais
Cicatriz/etiologia
Cicatriz/metabolismo
Cicatriz/patologia
Colágeno Tipo I/análise
Colágeno Tipo III/análise
Feminino
Furões
Fibronectinas/análise
Laringoscopia/instrumentação
Laringoscopia/métodos
Modelos Anatômicos
Membrana Mucosa/patologia
Membrana Mucosa/cirurgia
Coelhos
Ratos
Prega Vocal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Collagen Type I); 0 (Collagen Type III); 0 (Fibronectins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417750165


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[PMID]:29298508
[Au] Autor:Liu K; Ge P; Sheng X; Jiang J; Qin H
[Ad] Endereço:1 Department of Laryngopharynx Head & Neck Maxillofacial Surgery, Guangdong General Hospital and Guangdong Academy of Medical Sciences, School of Medicine, South China University Technology, Guangzhou City, PR China.
[Ti] Título:Survival in Vivo Canine Phonation Model Without Stimulation.
[So] Source:Ann Otol Rhinol Laryngol;127(3):178-184, 2018 Mar.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We describe a survival nonstimulated in vivo canine phonation model using distending laryngoscope, cramp frame, and constant humidified glottal airflow to elicit phonation. METHODS: Five beagle dogs were involved in this study. One cuffed endotracheal tube was placed below the glottis through the tracheotomy and delivered humidified airflow to the glottis. Arytenoids approximation was maintained using a clamp under the distending laryngoscope. Acoustic and aerodynamic parameters were measured using synchronous signal collection system and analysis software. Vocal oscillation also was examined using stroboscope laryngeal imaging. RESULTS: For the nonstimulated in vivo phonation animal, the sound intensity and fundamental frequency were 78.3 ± 6.8 dB and 127.6 ± 29.2 Hz in the first experiment and 82.9 ± 6.6 dB and 175.2 ± 4.4 Hz 4 weeks later. The aerodynamic analysis revealed the mean subglottal phonation threshold pressure (PTP) and phonation threshold flow (PTF) were 8.5 ± 4.0 cmH 0 and 683.0 ± 356.4 mL/s in the first experiment and 16.1 ± 8.6 cmH 0 and 384.8.0 ± 230.6 mL/s in the second experiment 4 weeks later. Stroboscope image revealed sustained vocal vibration during great airflow delivery to glottis in the phonation animal model. CONCLUSIONS: We developed a survival nonstimulated in vivo phonation canine model that allows the study of long-term animal phonation study as its own control.
[Mh] Termos MeSH primário: Laringoscopia
Fonação/fisiologia
Traqueotomia/métodos
Prega Vocal
[Mh] Termos MeSH secundário: Acústica/instrumentação
Animais
Cães
Laringoscopia/instrumentação
Laringoscopia/métodos
Modelos Animais
Estroboscopia/métodos
Prega Vocal/diagnóstico por imagem
Prega Vocal/fisiologia
Prega Vocal/fisiopatologia
Qualidade da Voz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180221
[Lr] Data última revisão:
180221
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180105
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417751473


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[PMID]:29297623
[Au] Autor:Svistushkin VM; Starostina SV; Lyundup AV; Dedova MG; Budeikina LS; Svistushkin MV; Krasheninnikov ME; Baranovskiy DS
[Ti] Título:The Possibilities of Cell Technologies in the Treatment of Cicatricial Lesions of the Vocal Folds.
[So] Source:Vestn Ross Akad Med Nauk;71(3):190-9, 2016.
[Is] ISSN:0869-6047
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The article is a brief review of publications devoted to the problem of persistent dysphonia. The main cause of voice disorders is the scarring of the vocal folds resulting from trauma, surgical manipulation, inflammatory process. Treatment of cicatricial lesions of the vocal folds remains a challenge, as far as existing methods do not ensure the recovery of the ultrastructure of the vocal folds. The authors present modern data on the structure of the vocal folds at the cellular level. Considered pathologic processes occur in different stages of scarring. Applied technologies of phonosurgery and conservative treatment, their effectiveness and shortcomings are covered. Analysis of experimental research conducted in the world demonstrates the promise of using the methods of tissue engineering to treat scarring of the vocal folds and to restore the microstructure of the latter. Identified current issues remain unresolved, which leads to the need for further experimental and clinical studies in the treatment of this pathology.
[Mh] Termos MeSH primário: Terapia Baseada em Transplante de Células e Tecidos/métodos
Disfonia
[Mh] Termos MeSH secundário: Cicatriz/complicações
Cicatriz/diagnóstico
Disfonia/etiologia
Disfonia/terapia
Seres Humanos
Engenharia Tecidual/métodos
Disfunção da Prega Vocal/complicações
Disfunção da Prega Vocal/diagnóstico
Prega Vocal/patologia
Prega Vocal/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


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[PMID]:29295971
[Au] Autor:Warner LL; Smischney N
[Ad] Endereço:Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA.
[Ti] Título:Special K with No License to Kill: Accidental Ketamine Overdose on Induction of General Anesthesia.
[So] Source:Am J Case Rep;19:10-12, 2018 Jan 03.
[Is] ISSN:1941-5923
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND Ketamine is used as an induction and sedation agent in emergency departments and operating rooms throughout the country. Despite its widespread clinical use, there are few cases of significant morbidity and mortality attributed to ketamine overdose in the clinical setting. CASE REPORT The anesthesia provider in the room was an oral maxillofacial surgeon who inadvertently took out a more highly concentrated bottle of ketamine that is typically used for pediatric patients. The patient received 950 mg (100 mg/ml concentration) of intravenous ketamine instead of the intended 95 mg (10 mg/ml concentration). After the ketamine was given, there were no signs to any involved provider that a mistake had occurred until the wake-up appeared to be unusually prolonged. CONCLUSIONS Despite this, the patient did not demonstrate any systemic effects such as hemodynamic or CNS perturbations other than prolonged awakening. This case highlights one (drug overdose) of many causes of delayed emergence from anesthesia and reminds the provider caring for the patient to be mindful of drug concentrations used when preparing to sedate a patient, as relying on effects of the parent drug is not always adequate.
[Mh] Termos MeSH primário: Anestesia Geral
Anestésicos Dissociativos
Recuperação Demorada da Anestesia/diagnóstico
Ketamina
Laringoscopia
Erros de Medicação
Prega Vocal/patologia
[Mh] Termos MeSH secundário: Idoso
Anestesia Geral/métodos
Anestésicos Dissociativos/efeitos adversos
Recuperação Demorada da Anestesia/terapia
Overdose de Drogas
Seres Humanos
Ketamina/efeitos adversos
Laringoscopia/métodos
Masculino
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Dissociative); 690G0D6V8H (Ketamine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE


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[PMID]:28744917
[Au] Autor:Elias-Costa AJ; Montesinos R; Grant T; Faivovich J
[Ad] Endereço:División Herpetología, Museo Argentino de Ciencias Naturales "Bernardino Rivadavia"-CONICET, Av. Angel Gallardo 470, Buenos Aires, C1405DJR, Argentina.
[Ti] Título:The vocal sac of Hylodidae (Amphibia, Anura): Phylogenetic and functional implications of a unique morphology.
[So] Source:J Morphol;278(11):1506-1516, 2017 Nov.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Anuran vocal sacs are elastic chambers that recycle exhaled air during vocalizations and are present in males of most species of frogs. Most knowledge of the diversity of vocal sacs relates to external morphology; detailed information on internal anatomy is available for few groups of frogs. Frogs of the family Hylodidae, which is endemic to the Atlantic Forest of Brazil and adjacent Argentina and Paraguay, have three patterns of vocal sac morphology-that is, single, subgular; paired, lateral; and absent. The submandibular musculature and structure of the vocal sac mucosa (the internal wall of the vocal sac) of exemplar species of this family and relatives were studied. In contrast to previous accounts, we found that all species of Crossodactylus and Hylodes possess paired, lateral vocal sacs, with the internal mucosa of each sac being separate from the contralateral one. Unlike all other frogs for which data are available, the mucosa of the vocal sacs in these genera is not supported externally by the mm. intermandibularis and interhyoideus. Rather, the vocal sac mucosa projects through the musculature and is free in the submandibular lymphatic sac. The presence of paired, lateral vocal sacs, the internal separation of the sac mucosae, and their projection through the m. interhyoideus are synapomorphies of the family. Furthermore, the specific configuration of the m. interhyoideus allows asymmetric inflation of paired vocal sacs, a feature only reported in species of these diurnal, stream-dwelling frogs.
[Mh] Termos MeSH primário: Anuros/anatomia & histologia
Filogenia
Prega Vocal/anatomia & histologia
[Mh] Termos MeSH secundário: Animais
Argentina
Brasil
Diferenciação Celular
Masculino
Pele/citologia
Glândula Submandibular/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.20727


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[PMID]:28467327
[Au] Autor:Bruzzi C; Salsi D; Minghetti D; Negri M; Casolino D; Sessa M
[Ad] Endereço:ENT UNIT Carpi Bernardino Ramazzini Hospital. catebruzzi@gmail.com.
[Ti] Título:Presbiphonya.
[So] Source:Acta Biomed;88(1):6-10, 2017 Apr 28.
[Is] ISSN:0392-4203
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:AIM: This article attempts to describe the aging process of the vocal folds and the main features of the aged voice. BACKGROUND: In the world ageing population era, aging diseases and aging disorders are crucial. Voice disorders (presbyphonia) are common in the elderly and have a significant impact on communication and quality of life. Some of these disorders depend on the vocal folds, which consist of an extracellular matrix (ECM), fibrous proteins, interstitial proteins, and glycosaminoglycans. The density and spatial arrangement of these elements are important, as changes in their deposition can alter the biomechanical properties and vibratory function of the vocal folds. DISCUSSION: The aging voice process is analyzed in detail from mechanical factors like pulmonary bellows alteration, to hormonal factors and life style. CONCLUSIONS: The elderly people undergoe mechanical, anatomical and functional changes: alterations of the pulmonary bellows, systemic changes like hormonal disregulation, and laryngeal changes, that resulting in hoarseness, which is difficult to treat.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Qualidade da Voz/fisiologia
[Mh] Termos MeSH secundário: Hormônios Esteroides Gonadais/sangue
Seres Humanos
Estilo de Vida
Fonação/fisiologia
Músculos Respiratórios/fisiopatologia
Prega Vocal/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Gonadal Steroid Hormones)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180125
[Lr] Data última revisão:
180125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.23750/abm.v88i1.5266


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[PMID]:29241348
[Au] Autor:Kim M; Sadoughi B
[Ad] Endereço:1 Sean Parker Institute for the Voice, Department of Otolaryngology-Head and Neck Surgery, Weill Cornell Medical College/NewYork-Presbyterian Hospital, New York, New York, USA.
[Ti] Título:The Voice of Autoimmunity: Antisynthetase Syndrome Manifesting as Vocal Fold Bamboo Nodes.
[So] Source:Ann Otol Rhinol Laryngol;127(2):128-130, 2018 Feb.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To describe a case of vocal fold bamboo nodes leading to the diagnosis of antisynthetase syndrome, a rare autoimmune disorder. To highlight the link between these laryngeal lesions and autoimmunity. METHODS: A case of vocal fold bamboo nodes in a patient with long-standing interstitial lung disease is presented. The presence of these characteristic lesions prompted a rheumatologic workup that led to the diagnosis of a rare autoimmune disorder. RESULTS: The patient was ultimately diagnosed with antisynthetase syndrome, a rare condition characterized by inflammatory myositis and interstitial lung disease. She was treated with steroids and immunosuppressive agents with improvement in her symptoms and clinical findings. CONCLUSIONS: Vocal fold bamboo nodes are pathognomonic signs of autoimmunity. Management consists primarily of medical treatment of the underlying systemic disorder. Intralesional steroid injection or phonomicrosurgical excision may be considered for refractory cases.
[Mh] Termos MeSH primário: Doenças Autoimunes/diagnóstico
Disfonia/diagnóstico
Doenças da Laringe/diagnóstico
Doenças Pulmonares Intersticiais/diagnóstico
Doença Mista do Tecido Conjuntivo/diagnóstico
Miosite/diagnóstico
Nódulo Reumatoide/diagnóstico
Prega Vocal/patologia
[Mh] Termos MeSH secundário: Doenças Autoimunes/tratamento farmacológico
Diagnóstico Diferencial
Disfonia/tratamento farmacológico
Disfonia/patologia
Feminino
Seres Humanos
Doenças da Laringe/tratamento farmacológico
Doenças da Laringe/patologia
Laringoscopia
Doenças Pulmonares Intersticiais/tratamento farmacológico
Doenças Pulmonares Intersticiais/patologia
Meia-Idade
Doença Mista do Tecido Conjuntivo/tratamento farmacológico
Miosite/tratamento farmacológico
Prednisona/uso terapêutico
Nódulo Reumatoide/tratamento farmacológico
Nódulo Reumatoide/patologia
Gravação em Vídeo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
VB0R961HZT (Prednisone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417748331


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[PMID]:29231041
[Au] Autor:Carroll TL; Dezube A; Bauman LA; Mallur PS
[Ad] Endereço:1 Department of Otolaryngology, Harvard Medical School, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA.
[Ti] Título:Using Trial Vocal Fold Injection to Select Vocal Fold Scar Patients Who May Benefit From More Durable Augmentation.
[So] Source:Ann Otol Rhinol Laryngol;127(2):105-112, 2018 Feb.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Clinical indications for vocal fold injection augmentation (VFI) are expanding. Prior studies demonstrate the benefit of trial VFI for select causes of glottic insufficiency. No studies have examined trial VFI for glottic insufficiency resulting from true vocal fold (TVF) scar. METHODS: Retrospective chart review of patients who underwent trial VFI for a dominant pathology of TVF scar causing dysphonia. Patients who subsequently underwent durable augmentation were identified. The primary study outcome was the difference in Voice Handicap Index-10 (VHI-10) score from pretrial VFI to post-durable augmentation. RESULTS: Twenty-eight patients underwent trial VFI for TVF scar, 22 of whom reported a positive response. Fifteen of 22 subjects who underwent durable augmentation had viable data for analysis. Mean VHI-10 improved from 26.9 to 18.6 ( P < .05), for a delta VHI-10 of 8.3, or 30.9% improvement. Twelve of the 15 (80%) showed a clinically significant improvement (delta VHI-10 >5). CONCLUSIONS: A trial VFI is a potentially useful, low-risk procedure that appears to help the patient and clinician identify when global augmentation might improve the voice when vocal fold scar is present. Patients who reported successful trial VFI often demonstrated significant improvement in their VHI-10 after subsequent durable augmentation.
[Mh] Termos MeSH primário: Carboximetilcelulose Sódica/administração & dosagem
Cicatriz/terapia
Disfonia/terapia
Doenças da Laringe/terapia
Prega Vocal
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Cicatriz/complicações
Disfonia/etiologia
Feminino
Seguimentos
Seres Humanos
Injeções
Masculino
Meia-Idade
Satisfação do Paciente
Estudos Retrospectivos
Qualidade da Voz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
K679OBS311 (Carboxymethylcellulose Sodium)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417746188


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[PMID]:29224772
[Au] Autor:Jabbour J; Robey T
[Ad] Endereço:Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital/Harvard Medical School, 300 Longwood Ave, BCH 3129, Boston, MA 02115, USA. Electronic address: jad.jabbour@childrens.harvard.edu.
[Ti] Título:Resolution of vocal fold immobility in preterm infants.
[So] Source:Int J Pediatr Otorhinolaryngol;103:83-86, 2017 Dec.
[Is] ISSN:1872-8464
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Vocal fold immobility (VFI) is an important sequela of preterm birth due to patent ductus arteriosus (PDA) ligation and invasive ventilation. A minority of these patients experience VFI resolution. The purpose of this study is to determine factors associated with VFI resolution in preterm infants. METHODS: This is a case control study of preterm (<37 weeks gestation) infants admitted to a metropolitan Level IV neonatal intensive care unit from 2006 to 2012. All patients diagnosed with VFI by flexible nasolaryngoscopy were divided into 2 cohorts: those with and without laryngoscopic resolution of VFI during follow-up. Univariate and multivariate analyses were performed to determine factors associated with VFI resolution. RESULTS: Of 71 patients with VFI and adequate follow-up, 17 (23.9%) experienced resolution. Median (range) follow-up was 25.7 (0.4-91.3) months and time to resolution 4.4 (0.4-38.8) months. Compared to the ongoing-VFI cohort, those who experienced resolution had higher median gestational age (31 vs 25 weeks, p = 0.006) and birth weight (1550 vs 765 g, p = 0.02), and lower likelihood of undergoing PDA ligation (47.1% vs 77.8%, p = 0.02). On multivariate analysis, history of PDA ligation remained independently associated with a lower likelihood of VFI resolution (p = 0.02, OR 0.2, 95% CI 0.1-0.8). Among PDA ligation patients, birth weight >1000 g was more common in the resolution cohort compared to the ongoing-VFI cohort (62.5% vs 24.4%, p = 0.047). CONCLUSION: While lower birth weight and gestational age are known risk factors for VFI following PDA ligation, in this study, these factors were also associated with a decreased likelihood of VFI resolution. Furthermore, PDA ligation appears to be a risk for both the development and persistence of VFI. This evidence should inform prognosis and intervention decisions for preterm infants with VFI.
[Mh] Termos MeSH primário: Permeabilidade do Canal Arterial/cirurgia
Ligadura/efeitos adversos
Paralisia das Pregas Vocais/etiologia
[Mh] Termos MeSH secundário: Estudos de Casos e Controles
Feminino
Seguimentos
Idade Gestacional
Seres Humanos
Lactente
Recém-Nascido de Baixo Peso
Recém-Nascido
Recém-Nascido Prematuro
Unidades de Terapia Intensiva Neonatal
Laringoscopia
Masculino
Complicações Pós-Operatórias
Prognóstico
Fatores de Risco
Prega Vocal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171212
[St] Status:MEDLINE


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[PMID]:29078715
[Au] Autor:Dominguez LM; Brown RJ; Simpson CB
[Ad] Endereço:1 Department of Otolaryngology, UT Health Science Center San Antonio, San Antonio, Texas, USA.
[Ti] Título:Treatment Outcomes of In-Office KTP Ablation of Vocal Fold Granulomas.
[So] Source:Ann Otol Rhinol Laryngol;126(12):829-834, 2017 Dec.
[Is] ISSN:1943-572X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine the effectiveness of in-office potassium-titanyl-phosphate (KTP) treatment of vocal fold granulomas and identify any predictors of complete lesion resolution. METHODS: A retrospective review of patients who underwent in-office KTP ablation of vocal fold granulomas between 2007 and 2016 was performed. Medical records were reviewed for use of acid suppression medication, prior surgical treatment, voice therapy, laser settings, number of treatments, follow-up time, and Voice Handicap Index-10 (VHI-10) scores. RESULTS: Twenty-six patients underwent a total of 43 laser treatments. Eighty percent of patients were previously on acid suppression medication, and 42.3% had failed previous endoscopic treatments. Patients underwent a mean number of 1.65 ± 1.16 in-office treatments with decrease in size in 96.2% of cases. The VHI-10 was not significantly affected. Complete resolution occurred in 73.1% of cases with follow-up time ranging from 1 to 86 months (median = 9.5 months). No recurrences occurred in patients with complete resolution. Other than undergoing a single KTP treatment, no variable was found to be predictive of complete lesion resolution. Granuloma etiology was not predictive of lesion resolution but did correlate with symptom improvement. CONCLUSION: In-office pulsed KTP laser is an effective treatment option for vocal fold granulomas as the lesion resolves in the majority of cases.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Ambulatórios
Granuloma Laríngeo/cirurgia
Terapia a Laser
Lasers de Estado Sólido/uso terapêutico
Prega Vocal
[Mh] Termos MeSH secundário: Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Resultado do Tratamento
Qualidade da Voz
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171029
[St] Status:MEDLINE
[do] DOI:10.1177/0003489417738790



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