Base de dados : MEDLINE
Pesquisa : A04.411.125.500 [Categoria DeCS]
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[PMID]:29240753
[Au] Autor:Egawa K; Shimojima M; Taniguchi S; Nagata N; Tani H; Yoshikawa T; Kurosu T; Watanabe S; Fukushi S; Saijo M
[Ad] Endereço:United Graduate School of Veterinary Sciences, Gifu University, Gifu, Japan.
[Ti] Título:Virulence, pathology, and pathogenesis of Pteropine orthoreovirus (PRV) in BALB/c mice: Development of an animal infection model for PRV.
[So] Source:PLoS Negl Trop Dis;11(12):e0006076, 2017 Dec.
[Is] ISSN:1935-2735
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Cases of acute respiratory tract infection caused by Pteropine orthoreovirus (PRV) of the genus Orthoreovirus (family: Reoviridae) have been reported in Southeast Asia, where it was isolated from humans and bats. It is possible that PRV-associated respiratory infections might be prevalent in Southeast Asia. The clinical course of PRV is not fully elucidated. METHODS: The virulence, pathology, and pathogenesis of two PRV strains, a human-borne PRV strain (isolated from a patient, who returned to Japan from Bali, Indonesia in 2007) and a bat-borne PRV (isolated from a bat [Eonycteris spelaea] in the Philippines in 2013) were investigated in BALB/c mice using virological, pathological, and immunological study methods. RESULTS: The intranasal inoculation of BALB/c mice with human-borne PRV caused respiratory infection. In addition, all mice with immunity induced by pre-inoculation with a non-lethal dose of PRV were completely protected against lethal PRV infection. Mice treated with antiserum with neutralizing antibody activity after inoculation with a lethal dose of PRV showed a reduced fatality rate. In this mouse model, bat-borne PRV caused respiratory infection similar to human-borne PRV. PRV caused lethal respiratory disease in an animal model of PRV infection, in which BALB/c mice were used. CONCLUSIONS: The BALB/c mouse model might help to accelerate research on the virulence of PRV and be useful for evaluating the efficacy of therapeutic agents and vaccines for the treatment and prevention of PRV infection. PRV was shown for the first time to be a causative virus of respiratory disease on the basis of Koch's postulations by the additional demonstration that PRV caused respiratory disease in mice through their intranasal inoculation with PRV.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Orthoreovirus/patogenicidade
Infecções por Reoviridae/patologia
Infecções por Reoviridae/virologia
Virulência
[Mh] Termos MeSH secundário: Animais
Anticorpos Neutralizantes/uso terapêutico
Anticorpos Antivirais/uso terapêutico
Ásia Sudeste
Peso Corporal
Bronquíolos/patologia
Bronquíolos/virologia
Cercopithecus aethiops
Quirópteros/virologia
Feminino
Genoma Viral
Células HEK293
Seres Humanos
Indonésia
Japão
Pulmão/patologia
Pulmão/virologia
Camundongos
Camundongos Endogâmicos BALB C
Orthoreovirus/classificação
Orthoreovirus/genética
Orthoreovirus/isolamento & purificação
Filipinas
RNA Viral/análise
Infecções por Reoviridae/tratamento farmacológico
Infecções Respiratórias/tratamento farmacológico
Infecções Respiratórias/patologia
Infecções Respiratórias/virologia
Taxa de Sobrevida
Vacinas/farmacologia
Células Vero
Carga Viral
Ensaio de Placa Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Neutralizing); 0 (Antibodies, Viral); 0 (RNA, Viral); 0 (Vaccines)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171224
[Lr] Data última revisão:
171224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pntd.0006076


  2 / 330 MEDLINE  
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[PMID]:28871880
[Au] Autor:Nazif JM; Taragin BH; Azzarone G; Rinke ML; Liewehr S; Choi J; Esteban-Cruciani N
[Ad] Endereço:1 Children's Hospital at Montefiore, Bronx, NY, USA.
[Ti] Título:Clinical Factors Associated With Chest Imaging Findings in Hospitalized Infants With Bronchiolitis.
[So] Source:Clin Pediatr (Phila);56(11):1054-1059, 2017 Oct.
[Is] ISSN:1938-2707
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Despite recommendations against routine imaging, chest radiography (CXR) is frequently performed on infants hospitalized for bronchiolitis. We conducted a review of 811 infants hospitalized for bronchiolitis to identify clinical factors associated with imaging findings. CXR was performed on 553 (68%) infants either on presentation or during hospitalization; 466 readings (84%) were normal or consistent with viral illness. Clinical factors significantly associated with normal/viral imaging were normal temperature (odds ratio = 1.66; 95% CI = 1.03-2.67) and normal oxygen saturation (odds ratio = 1.77; 95% CI = 1.1-2.83) on presentation. Afebrile patients with normal oxygen saturations were nearly 3 times as likely to have a normal/viral CXR as patients with both fever and hypoxia. Our findings support the limited role of radiography in the evaluation of hospitalized infants with bronchiolitis, especially patients without fever or hypoxia.
[Mh] Termos MeSH primário: Bronquiolite/diagnóstico por imagem
Pacientes Internados/estatística & dados numéricos
Radiografia Torácica/métodos
[Mh] Termos MeSH secundário: Bronquíolos/diagnóstico por imagem
Estudos de Coortes
Feminino
Hospitalização
Seres Humanos
Lactente
Masculino
Razão de Chances
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1177/0009922817698802


  3 / 330 MEDLINE  
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[PMID]:28846719
[Au] Autor:Kim J; Heise RL; Reynolds AM; Pidaparti RM
[Ad] Endereço:College of Engineering, University of Georgia, Athens, Georgia, United States of America.
[Ti] Título:Aging effects on airflow dynamics and lung function in human bronchioles.
[So] Source:PLoS One;12(8):e0183654, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND OBJECTIVE: The mortality rate for patients requiring mechanical ventilation is about 35% and this rate increases to about 53% for the elderly. In general, with increasing age, the dynamic lung function and respiratory mechanics are compromised, and several experiments are being conducted to estimate these changes and understand the underlying mechanisms to better treat elderly patients. MATERIALS AND METHODS: Human tracheobronchial (G1 ~ G9), bronchioles (G10 ~ G22) and alveolar sacs (G23) geometric models were developed based on reported anatomical dimensions for a 50 and an 80-year-old subject. The aged model was developed by altering the geometry and material properties of the model developed for the 50-year-old. Computational simulations using coupled fluid-solid analysis were performed for geometric models of bronchioles and alveolar sacs under mechanical ventilation to estimate the airflow and lung function characteristics. FINDINGS: The airway mechanical characteristics decreased with aging, specifically a 38% pressure drop was observed for the 80-year-old as compared to the 50-year-old. The shear stress on airway walls increased with aging and the highest shear stress was observed in the 80-year-old during inhalation. A 50% increase in peak strain was observed for the 80-year-old as compared to the 50-year-old during exhalation. The simulation results indicate that there is a 41% increase in lung compliance and a 35%-50% change in airway mechanical characteristics for the 80-year-old in comparison to the 50-year-old. Overall, the airway mechanical characteristics as well as lung function are compromised due to aging. CONCLUSION: Our study demonstrates and quantifies the effects of aging on the airflow dynamics and lung capacity. These changes in the aging lung are important considerations for mechanical ventilation parameters in elderly patients. Realistic geometry and material properties need to be included in the computational models in future studies.
[Mh] Termos MeSH primário: Envelhecimento/fisiologia
Bronquíolos/fisiologia
Pulmão/fisiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Bronquíolos/anatomia & histologia
Seres Humanos
Pulmão/anatomia & histologia
Meia-Idade
Modelos Biológicos
Testes de Função Respiratória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171026
[Lr] Data última revisão:
171026
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183654


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[PMID]:28807783
[Au] Autor:Haney EF; Wu BC; Lee K; Hilchie AL; Hancock REW
[Ad] Endereço:Center for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, #232, 2259 Lower Mall Research Station, Vancouver, BC V6T 1Z4, Canada.
[Ti] Título:Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides.
[So] Source:Cell Chem Biol;24(8):969-980.e4, 2017 Aug 17.
[Is] ISSN:2451-9456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is increasing interest in developing cationic host defense peptides (HDPs) and their synthetic derivatives as antimicrobial, immunomodulatory, and anti-biofilm agents. These activities are often evaluated without considering biologically relevant concentrations of salts or serum; furthermore certain HDPs have been shown to aggregate in vitro. Here we examined the effect of aggregation on the immunomodulatory activity of a synthetic innate defense regulator peptide, 1018 (VRLIVAVRIWRR-NH ). A variety of salts and solutes were screened to determine their influence on 1018 aggregation, revealing that this peptide "salts out" of solution in an anion-specific and concentration-dependent manner. Furthermore, the immunomodulatory activity of 1018 was found to be inhibited under aggregation-promoting conditions. A series of 1018 derivatives were synthesized with the goal of disrupting this self-assembly process. Indeed, some derivatives exhibited reduced aggregation while maintaining certain immunomodulatory functions, demonstrating that it is possible to engineer optimized synthetic HDPs to avoid unwanted peptide aggregation.
[Mh] Termos MeSH primário: Peptídeos Catiônicos Antimicrobianos/química
Peptídeos Catiônicos Antimicrobianos/farmacologia
Imunomodulação/efeitos dos fármacos
Agregados Proteicos
[Mh] Termos MeSH secundário: Peptídeos Catiônicos Antimicrobianos/síntese química
Biofilmes/efeitos dos fármacos
Bronquíolos/efeitos dos fármacos
Bronquíolos/imunologia
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/imunologia
Seres Humanos
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/imunologia
Engenharia de Proteínas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimicrobial Cationic Peptides); 0 (Protein Aggregates); 0 (innate defense regulating peptide 1018)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE


  5 / 330 MEDLINE  
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[PMID]:28585897
[Au] Autor:Pyziel AM; Laskowski Z; Demiaszkiewicz AW; Höglund J
[Ad] Endereço:W. Stefanski Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warsaw, Poland.
[Ti] Título:Interrelationships of Dictyocaulus spp. in Wild Ruminants with Morphological Description of Dictyocaulus cervi n. sp. (Nematoda: Trichostrongyloidea) from Red Deer, Cervus elaphus.
[So] Source:J Parasitol;103(5):506-518, 2017 Oct.
[Is] ISSN:1937-2345
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lungworms from the genus Dictyocaulus cause parasitic bronchitis (dictyocaulosis) characterized by coughing and severe lung pathology in both domestic and wild ruminants. In this study we investigated the interrelationships of Dictyocaulus spp. from European bison (Bison bonasus L.), roe deer (Capreolus capreolus), and red deer (Cervus elaphus) by nucleotide sequence analysis spanning the 18S RNA gene (small subunit [SSU]) and internal transcribed spacer 2 (ITS2) regions of the ribosomal gene array as well as the mitochondrial cytochrome c oxidase subunit 1 (cox1). Molecular analyses of sequence data obtained partly with novel primers from between 10 and 50 specimens from each host were carried out. Bayesian inference analysis revealed that each host species was infected with different genotypes. Analysis of cox1 sequence data showed a diverse genetic background and high evolutionary potential of Dictyocaulus taxa. Data from lungworms of European bison revealed a distinct genotype of Dictyocaulus viviparus, whereas Dictyocaulus capreolus was only found in roe deer. In contrast, red deer were infected with a taxon with unique SSU, ITS2, and cox1 sequences. These results indicate the occurrence of a novel genotype from red deer, which differs significantly from the National Center for Biotechnology Information reference sequence of Dictyocaulus eckerti. The molecular evidence was consistent with a morphological study with description and imaging of Dictyocaulus cervi n. sp. recovered from red deer. Dictyocaulus cervi n. sp. can be distinguished from D. eckerti on the basis of the absence of cervical papillae, the occurrence of a single ring of 4 symmetrical submedian cephalic papillae, length of the tail in females, morphometry of the female reproductive system, and measurements of gubernacula in males. In conclusion, our findings further strengthen the idea that the genetic complexity and diversity among Dictyocaulus lungworms infecting wildlife ruminants is larger than previously believed and warrants further investigation.
[Mh] Termos MeSH primário: Animais Selvagens/parasitologia
Cervos/parasitologia
Infecções por Dictyocaulus/parasitologia
Dictyocaulus/fisiologia
Ruminantes/parasitologia
[Mh] Termos MeSH secundário: Animais
Teorema de Bayes
Bison/parasitologia
Brônquios/parasitologia
Bronquíolos/parasitologia
DNA de Helmintos/química
DNA de Helmintos/isolamento & purificação
DNA Espaçador Ribossômico/química
Dictyocaulus/anatomia & histologia
Dictyocaulus/classificação
Dictyocaulus/genética
Infecções por Dictyocaulus/epidemiologia
Complexo IV da Cadeia de Transporte de Elétrons/genética
Feminino
Masculino
Filogenia
Polônia/epidemiologia
Prevalência
RNA Ribossômico 18S/genética
Traqueia/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Helminth); 0 (DNA, Ribosomal Spacer); 0 (RNA, Ribosomal, 18S); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170607
[St] Status:MEDLINE
[do] DOI:10.1645/16-75


  6 / 330 MEDLINE  
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[PMID]:28402849
[Au] Autor:Guha A; Deshpande A; Jain A; Sebastiani P; Cardoso WV
[Ad] Endereço:Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bengaluru 560065, India; Pulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA. Electronic address: arjung@instem.res.in.
[Ti] Título:Uroplakin 3a Cells Are a Distinctive Population of Epithelial Progenitors that Contribute to Airway Maintenance and Post-injury Repair.
[So] Source:Cell Rep;19(2):246-254, 2017 Apr 11.
[Is] ISSN:2211-1247
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is evidence that certain club cells (CCs) in the murine airways associated with neuroepithelial bodies (NEBs) and terminal bronchioles are resistant to the xenobiotic naphthalene (Nap) and repopulate the airways after Nap injury. The identity and significance of these progenitors (variant CCs, v-CCs) have remained elusive. A recent screen for CC markers identified rare Uroplakin3a (Upk3a)-expressing cells (U-CCs) with a v-CC-like distribution. Here, we employ lineage analysis in the uninjured and chemically injured lungs to investigate the role of U-CCs as epithelial progenitors. U-CCs proliferate and generate CCs and ciliated cells in uninjured airways long-term and, like v-CCs, after Nap. U-CCs have a higher propensity to generate ciliated cells than non-U-CCs. Although U-CCs do not contribute to alveolar maintenance long-term, they generate alveolar type I and type II cells after Bleomycin (Bleo)-induced alveolar injury. Finally, we report that Upk3a cells exist in the NEB microenvironment of the human lung and are aberrantly expanded in conditions associated with neuroendocrine hyperplasias.
[Mh] Termos MeSH primário: Bronquíolos/metabolismo
Microambiente Celular/genética
Células-Tronco/metabolismo
Uroplaquina III/biossíntese
[Mh] Termos MeSH secundário: Animais
Bleomicina/toxicidade
Bronquíolos/efeitos dos fármacos
Bronquíolos/lesões
Linhagem da Célula/efeitos dos fármacos
Microambiente Celular/efeitos dos fármacos
Células Epiteliais/efeitos dos fármacos
Células Epiteliais/metabolismo
Células Epiteliais/patologia
Seres Humanos
Camundongos
Naftalenos/toxicidade
Corpos Neuroepiteliais/metabolismo
Corpos Neuroepiteliais/patologia
Alvéolos Pulmonares/lesões
Células-Tronco/efeitos dos fármacos
Uroplaquina III/genética
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Naphthalenes); 0 (Upk3a protein, mouse); 0 (Uroplakin III); 11056-06-7 (Bleomycin); 2166IN72UN (naphthalene)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE


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[PMID]:28258195
[Au] Autor:Zhao Y; Jamaluddin M; Zhang Y; Sun H; Ivanciuc T; Garofalo RP; Brasier AR
[Ad] Endereço:Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX 77555.
[Ti] Título:Systematic Analysis of Cell-Type Differences in the Epithelial Secretome Reveals Insights into the Pathogenesis of Respiratory Syncytial Virus-Induced Lower Respiratory Tract Infections.
[So] Source:J Immunol;198(8):3345-3364, 2017 Apr 15.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Lower respiratory tract infections from respiratory syncytial virus (RSV) are due, in part, to secreted signals from lower airway cells that modify the immune response and trigger airway remodeling. To understand this process, we applied an unbiased quantitative proteomics analysis of the RSV-induced epithelial secretory response in cells representative of the trachea versus small airway bronchiolar cells. A workflow was established using telomerase-immortalized human epithelial cells that revealed highly reproducible cell type-specific differences in secreted proteins and nanoparticles (exosomes). Approximately one third of secretome proteins are exosomal; the remainder are from lysosomal and vacuolar compartments. We applied this workflow to three independently derived primary human cultures from trachea versus bronchioles. A total of 577 differentially expressed proteins from control supernatants and 966 differentially expressed proteins from RSV-infected cell supernatants were identified at a 1% false discovery rate. Fifteen proteins unique to RSV-infected primary human cultures from trachea were regulated by epithelial-specific ets homologous factor. A total of 106 proteins unique to RSV-infected human small airway epithelial cells was regulated by the transcription factor NF-κB. In this latter group, we validated the differential expression of CCL20/macrophage-inducible protein 3α, thymic stromal lymphopoietin, and CCL3-like 1 because of their roles in Th2 polarization. CCL20/macrophage-inducible protein 3α was the most active mucin-inducing factor in the RSV-infected human small airway epithelial cell secretome and was differentially expressed in smaller airways in a mouse model of RSV infection. These studies provide insights into the complexity of innate responses and regional differences in the epithelial secretome participating in RSV lower respiratory tract infection-induced airway remodeling.
[Mh] Termos MeSH primário: Remodelação das Vias Aéreas/imunologia
Bronquíolos/imunologia
Proteômica/métodos
Infecções por Vírus Respiratório Sincicial/imunologia
Infecções Respiratórias/imunologia
[Mh] Termos MeSH secundário: Bronquíolos/metabolismo
Células Cultivadas
Seres Humanos
Mucosa Respiratória/imunologia
Mucosa Respiratória/metabolismo
Infecções por Vírus Respiratório Sincicial/metabolismo
Vírus Sincicial Respiratório Humano/imunologia
Infecções Respiratórias/metabolismo
Traqueia/imunologia
Traqueia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170305
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1601291


  8 / 330 MEDLINE  
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[PMID]:28187270
[Au] Autor:Anas AA; Claushuis TAM; Mohan RA; Christoffels VM; Aidinis V; Florquin S; Van't Veer C; Hou B; de Vos AF; van der Poll T
[Ad] Endereço:1 Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
[Ti] Título:Epithelial Myeloid-Differentiation Factor 88 Is Dispensable during Klebsiella Pneumonia.
[So] Source:Am J Respir Cell Mol Biol;56(5):648-656, 2017 May.
[Is] ISSN:1535-4989
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Klebsiella pneumoniae is a common cause of pneumonia. Previous studies have documented an important role for Toll-like receptors (TLRs) expressed by myeloid cells in the recognition of K. pneumoniae and the initiation of a protective immune response. Lung epithelial cells also express TLRs and can participate in innate immune defense. The aim of this study was to examine the role of the common TLR adaptor protein myeloid-differentiation factor (MyD) 88 in lung epithelium during host defense against K. pneumoniae-induced pneumonia. To this end, we first crossed mice expressing cre recombinase under the control of the surfactant protein C (SftpCcre) or the club cell 10 kD (CC10cre) promoter with reporter mice to show that SftpCcre mice mainly express cre in type II alveolar cells, whereas CC10cre mice express cre almost exclusively in bronchiolar epithelial cells. We then generated mice with cell-targeted deletion of MyD88 in type II alveolar (SftpCcre-MyD88-lox) and bronchiolar epithelial (CC10cre-MyD88-lox) cells, and infected them with K. pneumoniae via the airways. Bacterial growth and dissemination were not affected by the loss of MyD88 in SftpCcre-MyD88-lox or CC10cre-MyD88-lox mice compared with control littermates. Furthermore, inflammatory responses induced by K. pneumoniae in the lung were not dependent on MyD88 expression in type II alveolar or bronchiolar epithelial cells. These results indicate that MyD88 expression in two distinct lung epithelial cell types does not contribute to host defense during pneumonia caused by a common human gram-negative pathogen.
[Mh] Termos MeSH primário: Células Epiteliais/metabolismo
Células Epiteliais/microbiologia
Infecções por Klebsiella/metabolismo
Klebsiella pneumoniae/fisiologia
Fator 88 de Diferenciação Mieloide/metabolismo
Pneumonia Bacteriana/metabolismo
[Mh] Termos MeSH secundário: Animais
Bronquíolos/patologia
Células Epiteliais/patologia
Inflamação/patologia
Integrases/metabolismo
Infecções por Klebsiella/microbiologia
Infecções por Klebsiella/patologia
Camundongos
Viabilidade Microbiana
Pneumonia Bacteriana/microbiologia
Pneumonia Bacteriana/patologia
Proteína C Associada a Surfactante Pulmonar/metabolismo
Uteroglobina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Myeloid Differentiation Factor 88); 0 (Pulmonary Surfactant-Associated Protein C); 0 (Scgb1a1 protein, mouse); 9060-09-7 (Uteroglobin); EC 2.7.7.- (Cre recombinase); EC 2.7.7.- (Integrases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.1165/rcmb.2016-0190OC


  9 / 330 MEDLINE  
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[PMID]:28079597
[Au] Autor:Trejo Bittar HE; Doberer D; Mehrad M; Strollo DC; Leader JK; Wenzel S; Yousem SA
[Ad] Endereço:Departments of *Pathology ‡Cardiothoracic Surgery, University of Pittsburgh Medical Center †Department of Medicine, Pulmonary Allergy and Critical Care Medicine Division, University of Pittsburgh Asthma Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
[Ti] Título:Histologic Findings of Severe/Therapy-Resistant Asthma From Video-assisted Thoracoscopic Surgery Biopsies.
[So] Source:Am J Surg Pathol;41(2):182-188, 2017 Feb.
[Is] ISSN:1532-0979
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The histologic changes occurring in severe/therapy-resistant asthma (SA) as defined by the European Respiratory Society/American Thoracic Society guidelines, particularly at the level of the distal airways are unknown. This study describes the clinical, radiologic, and histologic characteristics of 29 SA patients who underwent video-assisted thoracoscopic surgery lung biopsy. Pathologic observations were correlated with clinical features, especially the presence of autoimmune disease (AID) (15/29, 51.7%). Ten biopsies (10/29, 34.5%) showed only small airway manifestations of asthma, whereas in 19 (65.5%) asthmatic granulomatosis, manifested by asthmatic bronchiolitis supplemented by an alveolar septal mononuclear infiltrates with non-necrotizing granulomas, was present. SA patients without asthmatic granulomatosis showed more striking small airway injury, subbasement membrane thickening, and neutrophilic infiltrates. Cases with concurrent AID had a tendency to more parenchymal eosinophilic inflammation, more bronchiolocentric granulomas, and a suggestion of increased responsivity to nonsteroidal immunosuppressive therapy. Histologic examination of video-assisted thoracoscopic surgery lung biopsies in SA demonstrates diverse pathologies including cases associated with granulomatous inflammation in addition to eosinophilic infiltrates. This spectrum of histologies may link to a high incidence of AID.
[Mh] Termos MeSH primário: Asma/patologia
Doenças Autoimunes/complicações
Bronquíolos/patologia
Granuloma/patologia
[Mh] Termos MeSH secundário: Adulto
Asma/complicações
Doenças Autoimunes/epidemiologia
Biópsia
Resistência a Medicamentos
Feminino
Granuloma/epidemiologia
Seres Humanos
Masculino
Meia-Idade
Prevalência
Cirurgia Torácica Vídeoassistida
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1097/PAS.0000000000000777


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[PMID]:27852080
[Au] Autor:Crisafulli E; Pisi R; Aiello M; Vigna M; Tzani P; Torres A; Bertorelli G; Chetta A
[Ad] Endereço:Respiratory Disease and Lung Function Unit, Department of Clinical and Experimental Medicine, University of Parma, Parma, Italy.
[Ti] Título:Prevalence of Small-Airway Dysfunction among COPD Patients with Different GOLD Stages and Its Role in the Impact of Disease.
[So] Source:Respiration;93(1):32-41, 2017.
[Is] ISSN:1423-0356
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In chronic obstructive pulmonary disease (COPD) patients, small-airway dysfunction (SAD) is considered a functional hallmark of disease. However, the exact role of SAD in the clinical presentation of COPD is not yet completely understood; moreover, it is not known whether SAD may have a relationship with the impact of disease. OBJECTIVES: To evaluate the prevalence of SAD among COPD patients categorized by the old and the new GOLD classification and to ascertain whether there is a relationship between SAD and impact of disease measured by the COPD Assessment Test (CAT) questionnaire. METHODS: We prospectively enrolled COPD outpatients from the University Hospital of Parma. Using the impulse oscillometry system (IOS), we assessed the fall in resistance from 5 to 20 Hz (R5-R20), reactance at 5 Hz (X5), and resonant frequency (FRes) as markers of peripheral airway dysfunction. According to R5-R20 ≥0.07 or <0.07, the cohort was also categorized in patients with and without SAD, respectively. RESULTS: We studied 202 patients. In both GOLD classifications, a progressive increasing distribution of R5-R20 and FRes was reported with a decreasing of X5. Moreover, there was a significant correlation between R5-R20 and CAT (r = 0.527, p < 0.001). Finally, the presence of SAD (OR 11.96; 95% CI 4.53-31.58; p < 0.001) and use of ICS + LABA + LAMA (OR 5.31; 95% CI 1.88-15.02; p = 0.002) were independent predictors of higher impact (CAT score ≥10). CONCLUSION: In COPD patients, the presence of SAD, as assessed by IOS, progressively increases with GOLD classifications and it is closely related to the high impact of disease on health status.
[Mh] Termos MeSH primário: Bronquíolos/fisiopatologia
Doença Pulmonar Obstrutiva Crônica/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Estudos de Coortes
Feminino
Seres Humanos
Masculino
Meia-Idade
Doença Pulmonar Obstrutiva Crônica/classificação
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE



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