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[PMID]:29262449
[Au] Autor:Ge CX; Tai MZ; Chen T; Li KL; Qin ZP
[Ad] Endereço:Special Department of Hemangiomas, Linyi Tumor Hospital, Linyi 276001, Shandong Province, China.
[Ti] Título:[Treatment analyses of 143 patients with maxillofacial and cervical venous malformations involved in isthmus faucium area].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;52(12):909-914, 2017 Dec 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To analyze the clinical data and summarize therapeutic experiences of cervicofacial venous malformations involving isthmus faucium area. Clinical records from 143 patients with venous malformations involving isthmus faucium area treated at our hospital between January 2012 and January 2016 were reviewed. There were 70 males and 73 females. Age ranged from 1 to 52 years old, with a median age of 14.5 years. There were 19 cases with lesions involving in only 1 subanatomic area above and 124 cases with lesions involving in more than 1 subanatomic areas, including 63 cases with lesions involving in more than 2 areas. There were 50 patients presenting with additional maxillofacial and cervical lesions. Clinical symptoms included snoring ( =98), indistinct phonation ( =49), and tonsil hypertrophy more than degree â…¡ ( =19). Tracheotomy was performed in 3 patients prior to hospitalization, contigency tracheotomy during hospitalization in 10 patients, and oral trachea cannula in other patients. All therapeutic procedures, including single chemical ablation with ethanol injection ( =94), single lesion resection ( =9) and both of them ( =40), were performed under general anesthesia. Treatment remedies included mesh suture, macroglossia reduction and excision of maxillofacial and cervical lesions for patients presenting with extensive malformations extending to maxillofacial and cervical area. Tonsil resection were done in patients having tonsil venous malformations or tonsil hypertrophy more than degree II. Achauer's 4-grade criterion was applied to evaluate the treatment outcomes. SPSS 18.0 software was used to analyze the data. Trachea cannula were not extubated untill 24 to 48 hours after treatment. Emergency tracheotomy was done in 2 cases after extubations because of dyspnea, and successful extubations were obtained in other cases. There were no advents of pulmonary vascular spasm or pulmonary embolism. There was significant difference between before and after operation (snore: χ(2)=105.431, ambiguous pronunciation: χ(2)=59.698, tonsil hypertrophy more than degree â…¡: χ(2)=33.530, all <0.01). The patients were followed-up for 1-4 years, and there were 123 cases at grade â…£ (complete disappear of lesions in 62 cases without recurrence), 17 at grade â…¢ , 3 at grade â…¡, and no case at gradeâ… . Chemical ablation with ethanol injection for venous malformations involving isthmus faucium area is recommended, wheras combined remedies including injection, mesh suture, macroglossia reduction, and excision of cervicofacial lesions are suggested in treatment of extensive lesions extending to maxillofacial and cervical area. Tonsil resection should be done in patients having tonsil venous malformations or tonsil hypertrophy more than degree â…¡, which is safe and highly effective, with good reservation of function, in the treatment of maxillofacial and cervical venous malformations involving isthmus faucium area.
[Mh] Termos MeSH primário: Etanol/administração & dosagem
Orofaringe/irrigação sanguínea
Malformações Vasculares/terapia
Veias/anormalidades
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Pré-Escolar
Terapia Combinada/métodos
Feminino
Seres Humanos
Hipertrofia/cirurgia
Lactente
Injeções
Masculino
Meia-Idade
Pescoço/irrigação sanguínea
Tonsila Palatina/irrigação sanguínea
Tonsila Palatina/patologia
Tonsila Palatina/cirurgia
Recidiva
Traqueotomia
Resultado do Tratamento
Malformações Vasculares/complicações
Malformações Vasculares/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3K9958V90M (Ethanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180207
[Lr] Data última revisão:
180207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2017.12.007


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[PMID]:29304069
[Au] Autor:Kwetkat A; Pfister W; Pansow D; Pletz MW; Sieber CC; Hoyer H
[Ad] Endereço:Department of Geriatric Medicine, Jena University Hospital, Jena, Thuringia, Germany.
[Ti] Título:Naso- and oropharyngeal bacterial carriage in nursing home residents: Impact of multimorbidity and functional impairment.
[So] Source:PLoS One;13(1):e0190716, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: From April 2013 to February 2014 we performed a multicentre prospective cross-sectional study in 541 German nursing home residents. We determined pharyngeal carriage of Streptococcus pneumoniae (primary objective) and other bacteria (secondary objective) in naso- and oropharyngeal swabs by culture-based standard procedures and explored the influence of multimorbidity and functional status on bacterial carriage. METHODS: Socio-demographic data, vaccination status, multimorbidity, nutrition and functional status defined by Comprehensive Geriatric Assessment were evaluated. We estimated carriage rates with 95% confidence intervals (CI) and explored potential risk factors by logistic regression analysis. RESULTS: Pneumococcal post-serotyping carriage rate was 0.8% (95%CI 0.2-1.9%; 4/526). Serotyping revealed serotypes 4, 7F, 23B and 23F and S. pseudopneumoniae in two other cases. Odds of carriage were higher in men (Odds ratio OR 5.3 (95%CI 0.9-29.4)), in malnourished residents (OR 4.6 (0.8-25.7)), residents living in shared rooms (OR 3.0 (0.5-16.5)) or having contact with schoolchildren (OR 2.0 (0.2-17.6)). The most frequent pathogen was Staphylococcus aureus (prevalence 29.5% (25.6-33.6%)) with meticillin-resistant Staphylococcus aureus prevalence of 1.1%. Gram-negative bacteria (GNB) were found in 22.5% (19.0-26.3%) with a prevalence of extended-spectrum beta lactamase (ESBL) producing bacteria of 0.8%. Odds of S. aureus carriage were higher for immobility (OR 1.84 (1.15-2.93)) and cognitive impairment (OR 1.54 (0.98-2.40)). Odds of GNB carriage were higher in residents with more severe comorbidity (OR 1.13 (1.00-1.28)) and malnutrition (OR 1.54 (0.81-2.91)). CONCLUSIONS: Given the observed data, at least long-term carriage of S. pneumoniae in nursing home residents seems to be rare and rather unlikely to cause nursing home acquired pneumonia. The low rate of colonization with multi drug resistant (MDR) bacteria confirms that nursing home residency is not a risk factor for MDR pneumonia in Germany. For individual risk assessment in this susceptible population, immobility and malnutrition should be considered as signs of functional impairment as well as comorbidity.
[Mh] Termos MeSH primário: Portador Sadio/epidemiologia
Portador Sadio/microbiologia
Nariz/microbiologia
Casas de Saúde
Orofaringe/microbiologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Escherichia coli
Feminino
Alemanha
Seres Humanos
Modelos Logísticos
Masculino
Multimorbidade
Prevalência
Estudos Prospectivos
Fatores de Risco
Staphylococcus aureus
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190716


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[PMID]:29310398
[Au] Autor:Li X; Wang Y; Wang F; Li B; Sun S; Yang H
[Ad] Endereço:Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province.
[Ti] Título:An unusual case of oropharyngeal chordoma: A case report and literature review.
[So] Source:Medicine (Baltimore);96(48):e8963, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Chordomas are rare malignant neoplasms derived from incomplete regression of notochordal tissue along the cranio-coccygeal axis. Chordomas that develop in an atypical position are called ectopic chordomas, such as oropharyngeal chordomas (OCs). OCs are exceedingly rare; only 11 cases have been reported to date. Preoperative diagnosis is challenging, and an accurate diagnosis thus is based on postoperative pathologic examination findings and immunohistochemistry. Although surgical therapy and radiotherapy is performed in some patients, the 5-year survival rate is low. Increasingly more studies of chordomas have been based on molecular biology to increase the survival rate, and targeted therapy could be a new therapy in the future. PATIENT CONCERNS: The patient presented with a left oropharyngeal mass that had begun slowly enlarging 1 year previously. He reported a foreign body sensation and dysphonia during this time period. DIAGNOSES: The patient was initially diagnosed with a neurogenic tumor. Routine postoperative pathology showed that the mass was consistent with a chordoma. INTERVENTION: Mass resection was performed. OUTCOME: One year after the initial surgery, magnetic resonance imaging revealed block signal images at the left retropharyngeal space and clivus. The patient developed recurrence of the OC. LESSONS: Surgical resection is the mainstay of treatment for OC, and postoperative adjuvant radiotherapy is also important. An understanding of the unusual case described in this report may be helpful in diagnosing OC, and development of targeted therapy may help clinicians to provide novel treatment for patients with OC.
[Mh] Termos MeSH primário: Cordoma/diagnóstico
Cordoma/cirurgia
Neoplasias Orofaríngeas/diagnóstico
Neoplasias Orofaríngeas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Cordoma/patologia
Seres Humanos
Masculino
Neoplasias Orofaríngeas/patologia
Orofaringe/diagnóstico por imagem
Orofaringe/patologia
Orofaringe/cirurgia
Recidiva
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180110
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008963


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[PMID]:28938004
[Au] Autor:Choi JH; Lee JY; Cha J; Kim K; Hong SN; Lee SH
[Ad] Endereço:Department of Otorhinolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon Hospital, Bucheon, Korea.
[Ti] Título:Predictive models of objective oropharyngeal OSA surgery outcomes: Success rate and AHI reduction ratio.
[So] Source:PLoS One;12(9):e0185201, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The aim of this study was to develop a predictive model of objective oropharyngeal obstructive sleep apnea (OSA) surgery outcomes including success rate and apnea-hypopnea index (AHI) reduction ratio in adult OSA patients. STUDY DESIGN: Retrospective outcome research. METHODS: All subjects with OSA who underwent oropharyngeal and/or nasal surgery and were followed for at least 3 months were enrolled in this study. Demographic, anatomical [tonsil size (TS) and palate-tongue position (PTP) grade (Gr)], and polysomnographic parameters were analyzed. The AHI reduction ratio (%) was defined as [(postoperative AHI-preoperative AHI) x 100 / postoperative AHI], and surgical success was defined as a ≥ 50% reduction in preoperative AHI with a postoperative AHI < 20. RESULTS: A total of 156 consecutive OSAS adult patients (mean age ± SD = 38.9 ± 9.6, M / F = 149 / 7) were included in this study. The best predictive equation by Forward Selection likelihood ratio (LR) logistic regression analysis was: [Formula: see text]The best predictive equation according to stepwise multiple linear regression analysis was: [Formula: see text] (TS/PTP Gr = 1 if TS/PTP Gr 3 or 4, TS/PTP Gr = 0 if TS/PTP Gr 1 or 2). CONCLUSION: The predictive models for oropharyngeal surgery described in this study may be useful for planning surgical treatments and improving objective outcomes in adult OSA patients.
[Mh] Termos MeSH primário: Apneia Obstrutiva do Sono/diagnóstico
Apneia Obstrutiva do Sono/cirurgia
[Mh] Termos MeSH secundário: Adulto
Tomada de Decisões Assistida por Computador
Estudos de Viabilidade
Feminino
Seres Humanos
Funções Verossimilhança
Modelos Lineares
Modelos Logísticos
Masculino
Nariz/cirurgia
Orofaringe/cirurgia
Polissonografia
Prognóstico
Estudos Retrospectivos
Apneia Obstrutiva do Sono/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170923
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185201


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[PMID]:28934425
[Au] Autor:Schlaberg R; Ampofo K; Tardif KD; Stockmann C; Simmon KE; Hymas W; Flygare S; Kennedy B; Blaschke A; Eilbeck K; Yandell M; McCullers JA; Williams DJ; Edwards K; Arnold SR; Bramley A; Jain S; Pavia AT
[Ad] Endereço:Department of Pathology.
[Ti] Título:Human Bocavirus Capsid Messenger RNA Detection in Children With Pneumonia.
[So] Source:J Infect Dis;216(6):688-696, 2017 Sep 15.
[Is] ISSN:1537-6613
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Background: The role of human bocavirus (HBoV) in respiratory illness is uncertain. HBoV genomic DNA is frequently detected in both ill and healthy children. We hypothesized that spliced viral capsid messenger RNA (mRNA) produced during active replication might be a better marker for acute infection. Methods: As part of the Etiology of Pneumonia in the Community (EPIC) study, children aged <18 years who were hospitalized with community-acquired pneumonia (CAP) and children asymptomatic at the time of elective outpatient surgery (controls) were enrolled. Nasopharyngeal/oropharyngeal specimens were tested for HBoV mRNA and genomic DNA by quantitative polymerase chain reaction. Results: HBoV DNA was detected in 10.4% of 1295 patients with CAP and 7.5% of 721 controls (odds ratio [OR], 1.4 [95% confidence interval {CI}, 1.0-2.0]); HBoV mRNA was detected in 2.1% and 0.4%, respectively (OR, 5.1 [95% CI, 1.6-26]). When adjusted for age, enrollment month, and detection of other respiratory viruses, HBoV mRNA detection (adjusted OR, 7.6 [95% CI, 1.5-38.4]) but not DNA (adjusted OR, 1.2 [95% CI, .6-2.4]) was associated with CAP. Among children with no other pathogens detected, HBoV mRNA (OR, 9.6 [95% CI, 1.9-82]) was strongly associated with CAP. Conclusions: Detection of HBoV mRNA but not DNA was associated with CAP, supporting a pathogenic role for HBoV in CAP. HBoV mRNA could be a useful target for diagnostic testing.
[Mh] Termos MeSH primário: Bocavirus/isolamento & purificação
Proteínas do Capsídeo/genética
Infecções por Parvoviridae/diagnóstico
Pneumonia Viral/diagnóstico
RNA Mensageiro/isolamento & purificação
RNA Viral/isolamento & purificação
[Mh] Termos MeSH secundário: Doença Aguda
Bocavirus/genética
Estudos de Casos e Controles
Criança
Pré-Escolar
Infecções Comunitárias Adquiridas/diagnóstico
Infecções Comunitárias Adquiridas/virologia
Hospitalização
Seres Humanos
Lactente
Masculino
Nasofaringe/virologia
Orofaringe/virologia
Estudos Prospectivos
Manejo de Espécimes
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Nm] Nome de substância:
0 (Capsid Proteins); 0 (RNA, Messenger); 0 (RNA, Viral)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1093/infdis/jix352


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[PMID]:28874431
[Au] Autor:Gravel J; Ceroni D; Lacroix L; Renaud C; Grimard G; Samara E; Cherkaoui A; Renzi G; Schrenzel J; Manzano S
[Ad] Endereço:Departments of Pediatrics (Gravel), Microbiology (Renaud) and Orthopedics (Grimard), Centre hospitalier universitaire Sainte-Justine, Université de Montréal, Montréal, Que.; Departments of Paediatric Orthopedics (Ceroni, Samara) and Paediatric Emergency Medicine (Lacroix, Manzano), Clinical Microbio
[Ti] Título:Association between oropharyngeal carriage of and osteoarticular infection in young children: a case-control study.
[So] Source:CMAJ;189(35):E1107-E1111, 2017 Sep 05.
[Is] ISSN:1488-2329
[Cp] País de publicação:Canada
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: has been increasingly identified in patients with osteoarticular infections. Our main objective was to evaluate the association between carriage of in the oropharynx of preschool children and osteoarticular infections. METHODS: We conducted this prospective case-control study in 2 tertiary care pediatric hospitals (Canada and Switzerland) between 2014 and 2016. Potential cases were children aged 6 to 48 months with a presumptive diagnosis of osteoarticular infection according to the treating emergency physician. Confirmed cases were those with diagnosis of osteomyelitis or septic arthritis proven by positive findings on technetium-labelled bone scan or magnetic resonance imaging or identification of a microorganism in joint aspirate or blood. For each case, we recruited 4 age-matched controls from among children presenting to the same emergency department for trauma. The independent variable was presence of oropharyngeal DNA identified by a specific polymerase chain reaction assay. We determined the association between oropharyngeal carriage of and definitive osteoarticular infection. RESULTS: The parents of 77 children admitted for suspected osteoarticular infection and 286 controls were invited to participate and provided informed consent. We identified in the oropharynx of 46 (71%) of 65 confirmed cases and 17 (6%) of 286 controls; these results yielded an odds ratio of 38.3 (95% confidence interval 18.5-79.1). INTERPRETATION: Detection of oropharyngeal was strongly associated with osteoarticular infection among children presenting with symptoms suggestive of such infection.
[Mh] Termos MeSH primário: Artrite Infecciosa/microbiologia
Portador Sadio/microbiologia
Kingella kingae/isolamento & purificação
Infecções por Neisseriaceae/diagnóstico
Infecções por Neisseriaceae/epidemiologia
Osteomielite/microbiologia
[Mh] Termos MeSH secundário: Artrite Infecciosa/diagnóstico por imagem
Canadá
Estudos de Casos e Controles
Pré-Escolar
Feminino
Hospitais Pediátricos
Seres Humanos
Lactente
Imagem por Ressonância Magnética
Masculino
Razão de Chances
Orofaringe/microbiologia
Osteomielite/diagnóstico por imagem
Reação em Cadeia da Polimerase
Estudos Prospectivos
Suíça
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1503/cmaj.170127


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[PMID]:28863918
[Au] Autor:Karia H; Shrivastav S; Karia AK
[Ad] Endereço:Department of Orthodontics and Dentofacial Orthopedics, Vidya Shikshan Prasarak Mandal's Dental College, Nagpur, India. Electronic address: himijakaria@gmail.com.
[Ti] Título:Three-dimensional evaluation of the airway spaces in patients with and without cleft lip and palate: A digital volume tomographic study.
[So] Source:Am J Orthod Dentofacial Orthop;152(3):371-381, 2017 Sep.
[Is] ISSN:1097-6752
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Patients with cleft lip and palate (CLP) suffer from several esthetic and functional challenges. Comprehensive treatment of these patients involves orthognathic surgery that may lead to velopharyngeal insufficiency or reduction in lower airway. Several cases of airway insufficiency, velopharyngeal incompetence, snoring, hypopnea, and obstructive sleep apnea have been reported in subjects with CLP. The aim of this study was to compare the anteroposterior dimensions of the oropharyngeal airway at 5 levels, the height of the oropharyngeal column, and the volume of the oropharyngeal airway in subjects with and without CLP. METHODS: The sample consisted of 62 patients with CLP and 42 subjects with Angle Class I malocclusion. Anteroposterior dimension, height, and volume of the oropharyngeal airway were measured using the midsagittal and axial slices obtained from 3-dimensional digital volume tomographic scans for both groups. RESULTS: The anteroposterior dimensions of the airway were significantly reduced in the study subjects compared with the control group at the level of the postnasal spine, the base of the tongue, and the epiglottis. The airway dimensions measured on the axial sections at the level of the palatal and epiglottic plane were also significantly lower in the study group. The height and volume of the oropharyngeal airway were also significantly smaller in patients with CLP compared with subjects without CLP. CONCLUSIONS: Patients with CLP showed reduced dimensions and volumes of the oropharyngeal airway in all 3 planes compared with the control group.
[Mh] Termos MeSH primário: Fenda Labial/patologia
Fissura Palatina/patologia
Orofaringe/patologia
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Criança
Fenda Labial/diagnóstico por imagem
Fissura Palatina/diagnóstico por imagem
Feminino
Seres Humanos
Imagem Tridimensional/métodos
Masculino
Má Oclusão de Angle Classe I/diagnóstico por imagem
Má Oclusão de Angle Classe I/patologia
Orofaringe/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170915
[Lr] Data última revisão:
170915
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:170903
[St] Status:MEDLINE


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[PMID]:28855004
[Au] Autor:Karacaer F; Hamed I; Özogul F; Glew RH; Özcengiz D
[Ad] Endereço:1​Department of Anaesthesiology and Reanimation, School of Medicine, Cukurova University, Adana, Turkey.
[Ti] Título:The function of probiotics on the treatment of ventilator-associated pneumonia (VAP): facts and gaps.
[So] Source:J Med Microbiol;66(9):1275-1285, 2017 Sep.
[Is] ISSN:1473-5644
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Probiotics have been used for centuries in making fermented dairy products. The health benefits related to probiotics consumption are well recognized and they are generally regarded as safe (GRAS). Their therapeutic effects are due to the production of a variety of antimicrobial compounds, such as short-chain fatty acids, organic acids (such as lactic, acetic, formic, propionic and butyric acids), ethanol, hydrogen peroxide and bacteriocins. Ventilator-associated pneumonia (VAP) is a nosocomial infection associated with high mortality in intensive care units. VAP can result from endotracheal intubation and mechanical ventilation. These interventions increase the risk of infection as patients lose the natural barrier between the oropharynx and the trachea, which in turn facilitates the entry of pathogens through the aspiration of oropharyngeal secretions containing bacteria into the lung. In order to prevent this, probiotics have been used extensively against VAP. This review is an update containing information extracted from recent studies on the use of probiotics to treat VAP. In addition, probiotic safety, the therapeutic properties of probiotics, the probiotic strains used and the action of the probiotics mechanism are reviewed. Furthermore, the therapeutic effects of probiotic treatment procedures for VAP are compared to those of antibiotics. Finally, the influences of bacteriocin on the growth of human pathogens, and the side-effects and limitations of using probiotics for the treatment of VAP are addressed.
[Mh] Termos MeSH primário: Infecção Hospitalar/tratamento farmacológico
Intubação Intratraqueal/efeitos adversos
Pneumonia Associada à Ventilação Mecânica/terapia
Probióticos/uso terapêutico
Respiração Artificial/efeitos adversos
[Mh] Termos MeSH secundário: Antibacterianos/uso terapêutico
Bacteriocinas/uso terapêutico
Infecção Hospitalar/microbiologia
Seres Humanos
Unidades de Terapia Intensiva
Orofaringe/anatomia & histologia
Orofaringe/microbiologia
Pneumonia Associada à Ventilação Mecânica/microbiologia
Traqueia/anatomia & histologia
Traqueia/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Bacteriocins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1099/jmm.0.000579


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[PMID]:28699877
[Au] Autor:El Houmami N; Bakour S; Bzdrenga J; Rathored J; Seligmann H; Robert C; Armstrong N; Schrenzel J; Raoult D; Yagupsky P; Fournier PE
[Ad] Endereço:1​Aix-Marseille University, UM63, CNRS 7278, IRD 198, Inserm 1095, URMITE, Institut Hospitalo-Universitaire Méditerranée Infection, Marseille, France.
[Ti] Título:Isolation and characterization of Kingella negevensis sp. nov., a novel Kingella species detected in a healthy paediatric population.
[So] Source:Int J Syst Evol Microbiol;67(7):2370-2376, 2017 Jul.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We herein report the isolation and characterization of 21 Gram-stain-negative strains cultivated from the oropharynx of healthy children in Israel and Switzerland. Initially described as small colony variants of Kingella kingae, phenotypic analysis, biochemical analysis, phylogenetic analysis based on sequencing of the partial 16S rRNA gene and five housekeeping genes (abcZ, adk, G6PD, groEL and recA), and whole genome sequencing and comparison between members of the genera Kingella and Neisseria provided evidence for assigning them to the genus Kingella. Cellular fatty acids included important amounts of C12 : 0, C14 : 0, C16 : 0 and C16 : 1n7. Digital DNA-DNA hybridization between the isolates Sch538T and K. kingae ATCC 23330T revealed relatedness of 19.9 %. Comparative analysis of 16S rRNA gene sequences available in GenBank allowed matches to strains isolated in the USA, suggesting a wider geographical distribution. A novel species named Kingella negevensis sp. nov. is proposed, as most strains have been isolated in the Negev, a desert region of southern Israel. The type strain is Sch538T (=CCUG 69806T=CSUR P957).
[Mh] Termos MeSH primário: Kingella/classificação
Orofaringe/microbiologia
Filogenia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
Criança
DNA Bacteriano/genética
Ácidos Graxos/química
Genes Bacterianos
Seres Humanos
Israel
Kingella/genética
Kingella/isolamento & purificação
Hibridização de Ácido Nucleico
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Suíça
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001957


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[PMID]:28529003
[Au] Autor:Kim HJ; Kim SH; Min JY; Park WK
[Ad] Endereço:Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea. Electronic address: jjollong@gmail.com.
[Ti] Título:Determination of the appropriate oropharyngeal airway size in adults: Assessment using ventilation and an endoscopic view.
[So] Source:Am J Emerg Med;35(10):1430-1434, 2017 Oct.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Size 9 and 8 airways for men and women, respectively, have been proposed as most appropriate based on endoscopy. However, a limitation of this guideline is that ventilation was not assessed. METHODS: In this retrospective review of prospectively collected data, 149 patients requiring tracheal intubation for general anesthesia were included. The adequacy for manual and pressure-controlled mechanical ventilation and views at the distal end of each airway was assessed using a fiber-optic bronchoscope with various airway sizes (7, 8, 9, 10, and 11). RESULTS: For men, size 9, 10, and 11 airways permitted clear manual and adequate mechanical ventilation; size 7 and 8 airways caused partially obstructed manual and inadequate mechanical ventilation. On endoscopy, size 7 and 8 airways caused complete obstruction by the tongue; size 10 and 11 airways either touched or passed beyond the tip of the epiglottis. For women, the size 7 airway caused partially obstructed manual and inadequate mechanical ventilation; size 9 and 10 airways provided clear manual and adequate mechanical ventilation. The size 8 airway permitted clear manual ventilation, though mechanical ventilation was inadequate in one patient. On endoscopy, the size 7 airway caused complete obstruction in >50% of women; size 9, 10, and 11 airways either touched or passed beyond the tip of the epiglottis. CONCLUSIONS: With respect to adequate ventilation in conjunction with an acceptable endoscopic view, size 9 and size 8 oropharyngeal airways appear to be the most appropriate sizes for clinical use in men and women, respectively.
[Mh] Termos MeSH primário: Anestesia Geral
Broncoscopia
Intubação Intratraqueal
Orofaringe/patologia
Respiração Artificial
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Posicionamento do Paciente
Estudos Retrospectivos
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE



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