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[PMID]:29489700
[Au] Autor:Chen Q; Liu Q; Suo Y; Xie Q
[Ad] Endereço:Department of Hand Surgery, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, China.
[Ti] Título:A new surgical treatment for abdominal wall defects: A vascularized ribs-pleural transfer technique that can be used with or without a thoracic umbilical flap a case report.
[So] Source:Medicine (Baltimore);97(9):e9993, 2018 Mar.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Abdominal wall defects are common after tumor resection. PATIENT CONCERNS: We report an 83-year-old male patient with recurrent tumors in his abdomen, and who had an incision wound that could not be directly closed. Mesh was not suitable because the wound was infected. DIAGNOSES: Abdominal wall defect result from the resection of recurrent tumor. INTERVENTIONS: We carried out a vascularized ribs-pleural transfer operation. OUTCOMES: After the surgery, the patient gained a functional recovery. No evidence of recurrence was noted 1 year after operation, and the patient showed no symptoms of abdominal compression syndrome. LESSONS: We discuss the clinical diagnosis, treatment, and follow up and argue that the vascularized ribs-pleural transfer technique is a good method to deal with abdominal wall defects.
[Mh] Termos MeSH primário: Parede Abdominal/cirurgia
Pleura/transplante
Complicações Pós-Operatórias/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Costelas/transplante
[Mh] Termos MeSH secundário: Neoplasias Abdominais/cirurgia
Idoso de 80 Anos ou mais
Seres Humanos
Masculino
Recidiva Local de Neoplasia/cirurgia
Retalhos Cirúrgicos
Umbigo/transplante
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180301
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009993


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[PMID]:28453802
[Au] Autor:Kostron A; Friess M; Inci I; Hillinger S; Schneiter D; Gelpke H; Stahel R; Seifert B; Weder W; Opitz I
[Ad] Endereço:Division of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.
[Ti] Título:Propensity matched comparison of extrapleural pneumonectomy and pleurectomy/decortication for mesothelioma patients.
[So] Source:Interact Cardiovasc Thorac Surg;24(5):740-746, 2017 05 01.
[Is] ISSN:1569-9285
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The objective of this retrospective study was to assess perioperative outcomes, overall survival and freedom from recurrence after induction chemotherapy followed by extrapleural pneumonectomy (EPP) or pleurectomy/decortication (P/D) in patients with mesothelioma in a propensity score matched analysis. METHODS: Between September 1999 and August 2015, 167 patients received multimodality treatment (platinum-based chemotherapy followed by EPP [ n = 141] or P/D [ n = 26]). We performed 2:1 propensity score matching for gender, laterality, epithelioid histological subtype and International Mesothelioma Interest Group (iMig) stage (52 EPP and 26 P/D). RESULTS: Postoperative major morbidity (48% vs 58%, P = 0.5) was similar in both groups; however, the complication profile and severity were different and favoured P/D; the 90-day mortality (8% vs 0%, P = 0.3) rate was lower in P/D although not statistically significant. Prolonged air leak (≥10 days) occurred in 15 patients (58%) undergoing P/D. The intensive care unit stay was significantly longer after EPP ( P = 0.001). Freedom from recurrence was similar for both groups (EPP: median 15 months, 95% confidence interval [CI]: 10-21; P/D: 13 months, 95% CI: 11-17) ( P = 0.2). Overall survival was significantly longer for patients undergoing P/D (median 32 months, 95% CI: 29-35) compared to EPP (23 months, 95% CI: 21-25) ( P = 0.031), but in the P/D group many cases were censored (73%) and the follow-up time was relatively short. CONCLUSIONS: P/D and EPP seem to have similar rates of major morbidity, although the profile of complications is different and more severe after EPP. Freedom from recurrence is comparable in both groups whereas improved overall survival needs to be confirmed in a large patient group with longer follow-up.
[Mh] Termos MeSH primário: Mesotelioma/cirurgia
Pleura/cirurgia
Neoplasias Pleurais/cirurgia
Pneumonectomia/métodos
Complicações Pós-Operatórias/epidemiologia
Pontuação de Propensão
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seguimentos
Seres Humanos
Masculino
Mesotelioma/diagnóstico
Meia-Idade
Morbidade/tendências
Recidiva Local de Neoplasia/epidemiologia
Neoplasias Pleurais/diagnóstico
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Suíça/epidemiologia
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/icvts/ivw422


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[PMID]:29466146
[Au] Autor:Feller-Kopman D; Light R
[Ad] Endereço:From the Division of Pulmonary, Critical Care, and Sleep Medicine, Johns Hopkins University, Baltimore (D.F.-K.); and the Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University, Nashville (R.L.).
[Ti] Título:Pleural Disease.
[So] Source:N Engl J Med;378(8):740-751, 2018 02 22.
[Is] ISSN:1533-4406
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Empiema Pleural/terapia
Pleura/fisiopatologia
Derrame Pleural Maligno/terapia
Derrame Pleural/fisiopatologia
Pneumotórax/terapia
[Mh] Termos MeSH secundário: Diagnóstico Diferencial
Empiema Pleural/diagnóstico
Empiema Pleural/fisiopatologia
Exsudatos e Transudatos/fisiologia
Seres Humanos
Pleura/anatomia & histologia
Derrame Pleural/diagnóstico
Derrame Pleural/etiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180222
[St] Status:MEDLINE
[do] DOI:10.1056/NEJMra1403503


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[PMID]:29191359
[Au] Autor:Miller DL; Helms GA; Mayfield WR
[Ad] Endereço:WellStar Thoracic Surgery, WellStar Health System/Mayo Clinic Care Network, Marietta, Georgia. Electronic address: daniel.miller@wellstar.org.
[Ti] Título:Evaluation of Esophageal Anastomotic Integrity With Serial Pleural Amylase Levels.
[So] Source:Ann Thorac Surg;105(1):200-206, 2018 Jan.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: An anastomotic leak is the most devastating and potentially fatal complication after esophagectomy. Current detection methods can be inaccurate and place patients at risk of other complications. Analysis of pleural fluid for amylase may be more accurate and place patients at less of a risk for evaluating the integrity of an esophageal anastomosis. METHODS: We retrospectively reviewed prospective data of 45 consecutive patients who underwent an Ivor Lewis esophagectomy over an 18-month period and evaluated their anastomotic integrity with serial pleural amylase levels (PAL). RESULTS: There were 40 men (89%), and median age was 63 years (range, 35 to 79). Indication for esophagectomy was cancer in 38 patients (84%); 27 (71%) underwent neoadjuvant chemoradiation. A barium swallow was performed in the first 25 patients at median postoperative day (POD) 5 (range, 5 to 10); the swallow was negative in 23 patients (93%). Serial PALs were obtained starting on POD 3 and stopped 1 day after toleration of clear liquids. The PALs in the no-leak patients were highest on POD 3 (median 42 IU/L; range, 20 to 102 IU/L) and decreased (median 15 IU/L; range, 8 to 34 IU/L) to the lowest levels 1 day after clear liquid toleration (p = 0.04). Two patients had a leak and had peak PALs of 227 IU/L and 630 IU/L, respectively; both leaks occurred on POD 4, 1 day before their scheduled swallow test. The last 20 patients underwent serial PALs only, without a planned swallow test or computed tomography scan for anastomotic integrity evaluation. One of these patients had a leak on POD 5 with a low PAL of 55 IU/L the day before the spike of more than 4,000 IU/L. Two of the leaks were treated with esophageal stent placement and intravenous antibiotics, and the remaining patient's leak resolved with intravenous antibiotics, no oral intake, and observation only. None of the leak patients required transthoracic esophageal repair or drainage of an empyema. There was 1 postoperative death (2%) secondary to aspiration pneumonia on POD 10; no leak was ever identified, and the patient had been eating for 3 days before death. Complications occurred in 15 patients (33%), most commonly respiratory; no respiratory issues occurred in PAL-only evaluated patients. No late anastomotic leaks occurred in any patient while in the hospital or after discharge. CONCLUSIONS: Serial PALs for the detection of esophageal anastomotic leaks proved to be accurate, safe, and inexpensive. Elimination of barium swallows and computed tomography scans for evaluation of anastomotic integrity may decrease aspiration risks as well as associated pulmonary failure during the postoperative period. Serial PALs may be the preferred method of detecting an anastomotic leak after esophagectomy. A prospective randomized study is warranted.
[Mh] Termos MeSH primário: Amilases/análise
Fístula Anastomótica/diagnóstico
Líquidos Corporais/química
Esofagectomia
Esôfago/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Anastomose Cirúrgica
Feminino
Seres Humanos
Masculino
Meia-Idade
Pleura
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
EC 3.2.1.- (Amylases)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE


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[PMID]:28468931
[Au] Autor:Araki T; Yanagawa M; Sun FJ; Dupuis J; Nishino M; Yamada Y; Washko GR; Christiani DC; Tomiyama N; O'Connor GT; Hunninghake GM; Hatabu H
[Ad] Endereço:Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
[Ti] Título:Pleural abnormalities in the Framingham Heart Study: prevalence and CT image features.
[So] Source:Occup Environ Med;74(10):756-761, 2017 Oct.
[Is] ISSN:1470-7926
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The prevalence of pleural abnormalities in the general population is an epidemiologically important index of asbestos exposure, which has not been investigated since a radiography-based study in 1980. METHODS: We examined 2633 chest CT scans (mean 59.2 years, 50% female) from the Framingham Heart Study (FHS) for the presence and image characteristics of pleural plaques and diffuse pleural thickening. Demographics and pulmonary function were stratified by the presence of pleural abnormalities in association with interstitial lung abnormalities. RESULTS: Pleural abnormalities were present in 1.5% (95% CI 1.1% to 2.1%). Pleural lesions were most commonly bilateral (90.0%), multiple (77.5%), calcified (97.5%) and commonly involved posterior (lower: 92.5%, middle: 87.5%), anterior (upper: 77.5%, middle: 77.5%) and diaphragmatic areas (72.5%). Participants with pleural abnormalities were significantly older (75.7 years, p <0.0001), male (92.5%, p <0.0001), former or current smokers (80.0%, p <0.001) with higher pack-years (33.3, p <0.0001). No significant reduction was noted in pulmonary function measures (p=0.07-0.94) when adjusted for the associated covariates, likely due to small number of cases with pleural abnormalities. Information about prior history of asbestos exposure and occupation was not available. CONCLUSIONS: Pleural plaques and diffuse pleural thickening are present on CT in 1.5% of the FHS cohort. The current prevalence of the pleural abnormalities is smaller than that reported in the previous population-based study using chest radiography, likely representing lower asbestos exposure in recent decades. The posterior portion of the pleura is most frequently involved but the anterior portion is also commonly involved.
[Mh] Termos MeSH primário: Asbestos/efeitos adversos
Exposição Ambiental/efeitos adversos
Pleura/patologia
Doenças Pleurais/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Pulmão/efeitos dos fármacos
Pulmão/patologia
Masculino
Meia-Idade
Pleura/diagnóstico por imagem
Pleura/efeitos dos fármacos
Doenças Pleurais/diagnóstico por imagem
Doenças Pleurais/epidemiologia
Prevalência
Radiografia Torácica
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1332-21-4 (Asbestos)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171129
[Lr] Data última revisão:
171129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1136/oemed-2016-104178


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[PMID]:29049171
[Au] Autor:Hsu JS; Jaw TS; Yang CJ; Lin SF; Shih MP; Chou SH; Chong IW; Lin MY; Chiang IC
[Ad] Endereço:aDepartment of Radiology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung bDepartment of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung cDepartment of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung dDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung eSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung fDepartment of Pathology, Taipei Hospital, Ministry of Health and Welfare, New Taipei City gDepartment of Surgery, Kaohsiung Medical University Hospital, Kaohsiung hDepartment of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung iDivision of Chest Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung jDivision of Chest Medicine, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung kDivision of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung lFaculty of Renal Care, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
[Ti] Título:Convex border of peripheral non-small cell lung cancer on CT images as a potential indicator of pleural invasion.
[So] Source:Medicine (Baltimore);96(42):e7323, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the study is to evaluate the use of the tumor border in peripheral non-small cell lung cancer (NSCLC) as an indicator of pleural invasion.This retrospective study was performed at a single tertiary center. The analysis of 136 patients with peripheral NSCLC included 101 (74.3%) patients with pathologically proven pleural invasion and 35 (25.7%) patients without pleural invasion. The tumor borders on conventional computed tomography (CT) were classified into 5 types on lung window setting: type 1, S or reverse S border with a blunt angle; type 2, sharp angle; type 3, concave border with a blunt angle; type 4, straight border with a perpendicular angle; and type 5, convex border with a perpendicular or blunt angle. In patients with more than 1 tumor border type, the priority was type 5, 4, 3, 2, and 1. Blunt angle, pleural contact >3 cm, and adjacent pleural thickening were also recorded for comparison with pleural invasion of peripheral tumors.Tumor border types 2 and 5 significantly differed between patients with and without pleural invasion (P = .001 and P < .001, respectively). Patients with and without pleural invasion did not significantly differ in tumor border type 1, tumor border type 3, tumor border type 4, blunt angle, pleural contact >3 cm, or pleural thickening. Tumor border type 5 was a moderate indicator of pleural invasion with positive LR, 5.20; accuracy, 57%; sensitivity, 45%; specificity, 91%; PPV, 94%; and NPV, 36%. Tumor border type 2 was a weak indicator of pleural invasion with positive LR, 0.51; accuracy, 34%; sensitivity, 34%; specificity, 34%; PPV, 60%; and NPV, 15%.Tumor border type 5 has a high PPV and high specificity for predicting pleural invasion by peripheral NSCLC.
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
Neoplasias Pleurais/diagnóstico por imagem
Tomografia Computadorizada por Raios X/estatística & dados numéricos
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Carcinoma Pulmonar de Células não Pequenas/patologia
Feminino
Seres Humanos
Neoplasias Pulmonares/patologia
Masculino
Meia-Idade
Invasividade Neoplásica/diagnóstico por imagem
Pleura/diagnóstico por imagem
Pleura/patologia
Neoplasias Pleurais/patologia
Valor Preditivo dos Testes
Estudos Retrospectivos
Sensibilidade e Especificidade
Tomografia Computadorizada por Raios X/métodos
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171020
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007323


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[PMID]:28927949
[Au] Autor:Rose G; Siadecki S; Tansek R; Baranchuk N; Saul T
[Ad] Endereço:Mount Sinai St. Luke's Mount Sinai West, Department of Emergency Medicine, 1111 Amsterdam Avenue, New York, NY 10025, United States.
[Ti] Título:A novel method of assessing for lung sliding using Doppler imaging.
[So] Source:Am J Emerg Med;35(11):1738-1742, 2017 Nov.
[Is] ISSN:1532-8171
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ultrasound is an ideal modality in the emergency department (ED) to assess for pneumothorax given its rapid availability, portability, and repeatability to assess clinical status changes. Certain patient populations and clinical circumstances may present challenges to the performance of this examination. In this article, we review patterns of the presence or absence of lung sliding in the commonly utilized sonographic modes in the ED setting. We also describe a novel technique to evaluate lung sliding using tissue Doppler.
[Mh] Termos MeSH primário: Pulmão/diagnóstico por imagem
Pleura/diagnóstico por imagem
Pneumotórax/diagnóstico por imagem
Ultrassonografia Doppler/métodos
[Mh] Termos MeSH secundário: Serviço Hospitalar de Emergência
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE


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[PMID]:28823918
[Au] Autor:Hattori K; Nakadate K; Morii A; Noguchi T; Ogasawara Y; Ishii K
[Ad] Endereço:Department of Hygienic Chemistry, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan.
[Ti] Título:Exposure to nano-size titanium dioxide causes oxidative damages in human mesothelial cells: The crystal form rather than size of particle contributes to cytotoxicity.
[So] Source:Biochem Biophys Res Commun;492(2):218-223, 2017 Oct 14.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Exposure to nanoparticles such as carbon nanotubes has been shown to cause pleural mesothelioma similar to that caused by asbestos, and has become an environmental health issue. Not only is the percutaneous absorption of nano-size titanium dioxide particles frequently considered problematic, but the possibility of absorption into the body through the pulmonary route is also a concern. Nevertheless, there are few reports of nano-size titanium dioxide particles on respiratory organ exposure and dynamics or on the mechanism of toxicity. In this study, we focused on the morphology as well as the size of titanium dioxide particles. In comparing the effects between nano-size anatase and rutile titanium dioxide on human-derived pleural mesothelial cells, the anatase form was shown to be actively absorbed into cells, producing reactive oxygen species and causing oxidative damage to DNA. In contrast, we showed for the first time that the rutile form is not easily absorbed by cells and, therefore, does not cause oxidative DNA damage and is significantly less damaging to cells. These results suggest that with respect to the toxicity of titanium dioxide particles on human-derived mesothelial cells, the crystal form rather than the particle size has a greater effect on cellular absorption. Also, it was indicated that the difference in absorption is the primary cause of the difference in the toxicity against mesothelial cells.
[Mh] Termos MeSH primário: Dano ao DNA/efeitos dos fármacos
Células Epiteliais/efeitos dos fármacos
Nanoestruturas/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Titânio/toxicidade
[Mh] Termos MeSH secundário: Linhagem Celular
Cristalização
Células Epiteliais/citologia
Células Epiteliais/metabolismo
Células Epiteliais/patologia
Seres Humanos
Tamanho da Partícula
Pleura/citologia
Pleura/efeitos dos fármacos
Pleura/metabolismo
Pleura/patologia
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 15FIX9V2JP (titanium dioxide); D1JT611TNE (Titanium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170822
[St] Status:MEDLINE


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[PMID]:28734445
[Au] Autor:Yamamoto Y; Kanzaki R; Inoue M; Okumura M
[Ad] Endereço:Department of General Thoracic Surgery, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
[Ti] Título:Primary Solitary Fibrous Tumor of the Forearm With Frequent Late-Onset Recurrence in the Pleura.
[So] Source:Ann Thorac Surg;104(2):e173-e175, 2017 Aug.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Solitary fibrous tumor (SFT) is a relatively rare form of mesenchymal tumor that generally has a benign clinical course. However, SFTs have malignant potential. We report the case of a 36-year-old man with local relapse and frequent late-onset pleural metastasis of primary SFT of the forearm. Pleural metastasis was first seen 11 years after the initial operation. During a 17-year period, he underwent 5 surgical resections. He has been free of disease for 61 months since the most recent operation.
[Mh] Termos MeSH primário: Neoplasias Pleurais/secundário
Tumores Fibrosos Solitários/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Biópsia
Antebraço
Seres Humanos
Masculino
Metástase Neoplásica
Pleura
Neoplasias Pleurais/diagnóstico
Tomografia Computadorizada com Tomografia por Emissão de Pósitrons
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170724
[St] Status:MEDLINE


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[PMID]:28707542
[Au] Autor:de Fonseka D; Edey A; Stadon L; Viner J; Darby M; Maskell NA
[Ad] Endereço:1 Academic Respiratory Unit, University of Bristol , Bristol , UK.
[Ti] Título:The physiological consequences of different distributions of diffuse pleural thickening on CT imaging.
[So] Source:Br J Radiol;90(1077):20170218, 2017 Aug.
[Is] ISSN:1748-880X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Diffuse pleural thickening (DPT) refers to extensive visceral pleural fibrosis with adhesion formation to the parietal pleura obliterating the pleural space. The radiological definition of DPT remains controversial with most of the literature requiring the presence of an obliterated costophrenic angle (CPA) for defining DPT. We conducted a study to investigate the variable distributions of DPT and associated lung function deficit. METHODS: 85 patients referred to a pleural clinic with suspected pleural thickening were screened for our study. Data were collected from 37 patients with DPT confirmed on CT by size criteria (≥3 mm thick, ≥5 cm wide and ≥8 cm in length), and 21 controls with pleural plaques but no other pleuroparenchymal pathology. 27 patients were excluded. Groups were matched to age, body mass index and smoking history. RESULTS: The percentage of predicted forced vital capacity showed a gradual decline from 98.9% for the control group to 83.5% in the DPT without CPA obliteration group (p < 0.05), to 79.5% in the unilateral DPT group (p < 0.001) and 66.7% in the bilateral group (p < 0.001). Similar reductions were seen in the percentage of predicted total lung capacity in the DPT with no CPA obliteration group and the bilateral DPT group. CONCLUSION: Our study shows an incremental reduction in the forced vital capacity and total lung capacity in DPT without CPA obliteration, unilateral and bilateral DPT when compared with a matched control group. Advances in knowledge: Different distributions of DPT including no CPA obliteration can cause respiratory impairment, with bilateral DPT being the worst affected.
[Mh] Termos MeSH primário: Pleura/diagnóstico por imagem
Doenças Pleurais/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Feminino
Fibrose
Seres Humanos
Masculino
Meia-Idade
Pleura/patologia
Doenças Pleurais/patologia
Radiografia
Aderências Teciduais
Tomografia Computadorizada por Raios X
Capacidade Pulmonar Total
Capacidade Vital
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE
[do] DOI:10.1259/bjr.20170218



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