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  1 / 31007 MEDLINE  
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[PMID]:29244804
[Au] Autor:Siller SS; Sharma H; Li S; Yang J; Zhang Y; Holtzman MJ; Winuthayanon W; Colognato H; Holdener BC; Li FQ; Takemaru KI
[Ad] Endereço:Medical Scientist Training Program (MSTP), Stony Brook University, Stony Brook, New York, United States of America.
[Ti] Título:Conditional knockout mice for the distal appendage protein CEP164 reveal its essential roles in airway multiciliated cell differentiation.
[So] Source:PLoS Genet;13(12):e1007128, 2017 12.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Multiciliated cells of the airways, brain ventricles, and female reproductive tract provide the motive force for mucociliary clearance, cerebrospinal fluid circulation, and ovum transport. Despite their clear importance to human biology and health, the molecular mechanisms underlying multiciliated cell differentiation are poorly understood. Prior studies implicate the distal appendage/transition fiber protein CEP164 as a central regulator of primary ciliogenesis; however, its role in multiciliogenesis remains unknown. In this study, we have generated a novel conditional mouse model that lacks CEP164 in multiciliated tissues and the testis. These mice show a profound loss of airway, ependymal, and oviduct multicilia and develop hydrocephalus and male infertility. Using primary cultures of tracheal multiciliated cells as a model system, we found that CEP164 is critical for multiciliogenesis, at least in part, via its regulation of small vesicle recruitment, ciliary vesicle formation, and basal body docking. In addition, CEP164 is necessary for the proper recruitment of another distal appendage/transition fiber protein Chibby1 (Cby1) and its binding partners FAM92A and FAM92B to the ciliary base in multiciliated cells. In contrast to primary ciliogenesis, CEP164 is dispensable for the recruitment of intraflagellar transport (IFT) components to multicilia. Finally, we provide evidence that CEP164 differentially controls the ciliary targeting of membrane-associated proteins, including the small GTPases Rab8, Rab11, and Arl13b, in multiciliated cells. Altogether, our studies unravel unique requirements for CEP164 in primary versus multiciliogenesis and suggest that CEP164 modulates the selective transport of membrane vesicles and their cargoes into the ciliary compartment in multiciliated cells. Furthermore, our mouse model provides a useful tool to gain physiological insight into diseases associated with defective multicilia.
[Mh] Termos MeSH primário: Cílios/fisiologia
Proteínas dos Microtúbulos/fisiologia
[Mh] Termos MeSH secundário: Animais
Corpos Basais/metabolismo
Diferenciação Celular/fisiologia
Células Cultivadas
Centríolos/metabolismo
Cílios/genética
Cílios/metabolismo
Células Epiteliais/citologia
Feminino
Masculino
Proteínas de Membrana/metabolismo
Camundongos
Camundongos Knockout
Proteínas dos Microtúbulos/genética
Proteínas dos Microtúbulos/metabolismo
Proteínas Nucleares/metabolismo
Transporte Proteico
Traqueia/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (Microtubule Proteins); 0 (Nuclear Proteins)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180227
[Lr] Data última revisão:
180227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1007128


  2 / 31007 MEDLINE  
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[PMID]:29360847
[Au] Autor:Sutanto EN; Scaffidi A; Garratt LW; Looi K; Foo CJ; Tessari MA; Janssen RA; Fischer DF; Stick SM; Kicic A; AREST CF
[Ad] Endereço:Telethon Kids Institute, the University of Western Australia, Nedlands, Western Australia, Australia.
[Ti] Título:Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cells.
[So] Source:PLoS One;13(1):e0191618, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Mutations in the cystic fibrosis transmembrane regulator (CFTR) gene can reduce function of the CFTR ion channel activity and impair cellular chloride secretion. The gold standard method to assess CFTR function of ion transport using the Ussing chamber requires a high number of airway epithelial cells grown at air-liquid interface, limiting the application of this method for high throughput screening of potential therapeutic compounds in primary airway epithelial cells (pAECs) featuring less common CFTR mutations. This study assessed an alternative approach, using a small scale halide assay that can be adapted for a personalized high throughput setting to analyze CFTR function of pAEC. METHODS: Pediatric pAECs derived from children with CF (pAECCF) were established and expanded as monolayer cultures, before seeding into 96-well plates for the halide assay. Cells were then transduced with an adenoviral construct containing yellow fluorescent protein (eYFP) reporter gene, alone or in combination with either wild-type CFTR (WT-CFTR) or p.Phe508del CFTR. Four days post transduction, cells were stimulated with forskolin and genistein, and assessed for quenching of the eYFP signal following injection of iodide solution into the assay media. RESULTS: Data showed that pAECCF can express eYFP at high efficiency following transduction with the eYFP construct. The halide assay was able to discriminate functional restoration of CFTR in pAECCF treated with either WT-CFTR construct or the positive controls syntaxin 8 and B-cell receptor-associated protein 31 shRNAs. SIGNIFICANCE: The current study demonstrates that the halide assay can be adapted for pediatric pAECCF to evaluate restoration of CFTR function. With the ongoing development of small molecules to modulate the folding and/or activity of various mutated CFTR proteins, this halide assay presents a small-scale personalized screening platform that could assess therapeutic potential of molecules across a broad range of CFTR mutations.
[Mh] Termos MeSH primário: Brônquios/metabolismo
Regulador de Condutância Transmembrana em Fibrose Cística/fisiologia
Fibrose Cística/fisiopatologia
Fenilalanina/química
Traqueia/metabolismo
[Mh] Termos MeSH secundário: Adenoviridae/genética
Brônquios/citologia
Células Cultivadas
Criança
Fibrose Cística/patologia
Regulador de Condutância Transmembrana em Fibrose Cística/química
Regulador de Condutância Transmembrana em Fibrose Cística/genética
Células Epiteliais/metabolismo
Vetores Genéticos
Seres Humanos
Transporte Proteico
Traqueia/citologia
Transdução Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator); 47E5O17Y3R (Phenylalanine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180124
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191618


  3 / 31007 MEDLINE  
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[PMID]:29365389
[Au] Autor:Cui PC
[Ad] Endereço:Department of Otorhinolaryngology Head and Neck Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China.
[Ti] Título:[Advances in tracheal transplantation].
[So] Source:Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi;53(1):73-75, 2018 Jan 07.
[Is] ISSN:1673-0860
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:The length of tracheal defect or stenosis exceeded 5 cm could not be treated by simple resection and end-to-end anastomosis of the remaining trachea. Various ways of tracheal replacement had appeared sequentially, such as radial forearm free flap with cartilage grafts, tracheal tissue-engineering and tracheal allotransplantation. Among these methods, tracheal allotransplantation displayed a better long-term result. In this review, we are focused on recent advances in tracheal allotransplantation, particularly on revascularization and reepithelialization of graft, as well as on the application of immunosuppressive agents.
[Mh] Termos MeSH primário: Traqueia/transplante
[Mh] Termos MeSH secundário: Aloenxertos
Seres Humanos
Estenose Traqueal/cirurgia
Transplante/tendências
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180125
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.1673-0860.2018.01.019


  4 / 31007 MEDLINE  
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[PMID]:29390419
[Au] Autor:Park P; Kim J; Song YJ; Lim JH; Cho SW; Won TB; Han DH; Kim DY; Rhee CS; Kim HJ
[Ad] Endereço:Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Korea.
[Ti] Título:Influencing factors on CPAP adherence and anatomic characteristics of upper airway in OSA subjects.
[So] Source:Medicine (Baltimore);96(51):e8818, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Although continuous positive airway pressure (CPAP) is the most effective treatment modality, poor adherence still remains a problem for obstructive sleep apnea (OSA) treatment and there is little evidence regarding how this might be improved. This study aims to analyze the anatomic and clinical factors of OSA subjects who failed to comply with CPAP therapy.The medical records of 47 OSA subjects who received CPAP therapy as a first-line treatment modality were retrospectively reviewed. The medical records were reviewed for demographic and polysomnographic data and anatomic findings of the nasal cavity and oropharynx.24 patients who adhered to CPAP therapy and 23 patients who were nonadherent were enrolled in the study. There were no statistically significant differences in sleep parameters between CPAP-adherent patients and CPAP nonadherent subjects. Mean body mass index of CPAP nonadherent group was significantly higher than CPAP adherent group. Higher grades of septal deviation and hypertrophic change of the inferior turbinate were observed more in the CPAP nonadherent group. In addition, CPAP nonadherent subjects showed considerably bigger tonsils and higher grade palatal position comparing with the CPAP adherent subjects. Subjective discomfort including inconvenience, mouth dryness, and chest discomfort were the main problems for OSA subjects who did not comply with CPAP therapy.Excessive upper airway blockage in the nasal cavity and oropharynx was predominant in CPAP nonadherent subjects, which might cause the reported subjective discomfort that reduces CPAP compliance. Therefore, resolution of these issues is needed to enhance CPAP compliance for control of OSA.
[Mh] Termos MeSH primário: Pressão Positiva Contínua nas Vias Aéreas
Cooperação do Paciente
Apneia Obstrutiva do Sono/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Endoscopia
Feminino
Seres Humanos
Laringe/fisiopatologia
Masculino
Meia-Idade
Septo Nasal/fisiopatologia
Tonsila Palatina/fisiopatologia
Estudos Retrospectivos
Traqueia/fisiopatologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180213
[Lr] Data última revisão:
180213
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008818


  5 / 31007 MEDLINE  
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[PMID]:28468151
[Au] Autor:Pickrell BB; Meaike JD; Cañadas KT; Chandy BM; Buchanan EP
[Ad] Endereço:*Division of Plastic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine †Department of Otolaryngology, Texas Children's Hospital, Houston, TX.
[Ti] Título:Tracheal Cartilaginous Sleeve in Syndromic Craniosynostosis: An Underrecognized Source of Significant Morbidity and Mortality.
[So] Source:J Craniofac Surg;28(3):696-699, 2017 May.
[Is] ISSN:1536-3732
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tracheal cartilaginous sleeve (TCS) is a rare and previously unrecognized source of morbidity and mortality in patients with certain craniosynostosis syndromes. There is a paucity of reporting on this airway anomaly, and the true incidence of TCS is largely unknown. The purpose of this study was to investigate the incidence of TCS among patients with syndromic craniosynostosis at our institution. Patients with syndromic craniosynostosis who underwent direct bronchoscopy and laryngoscopy were evaluated retrospectively by pediatric otolaryngologists for the presence of TCS and associated anomalies. Among patients with a diagnosis of syndromic craniosynostosis in our craniofacial database, 10 (37%) were found to have previous direct bronchoscopy and laryngoscopy reports. Of these 10 patients, 2 had Crouzon syndrome, 3 had Pfeiffer syndrome, 3 had Apert syndrome, 1 had Muenke syndrome, and 1 had Antley-Bixler syndrome. Eighty percent (8/10) of these patients were found to have some evidence of TCS. The most commonly observed associated findings included the following: tracheostomy dependency (7/10; 70%), hearing loss (6/10; 60%), obstructive sleep apnea (5/10; 50%), cervical spine anomalies (5/10; 50%), developmental delay (5/10; 50%), and enlarged cerebral ventricles (4/10; 40%). Larger multicenter studies are required to further characterize this airway anomaly and its impact on this patient population. Our results confirm the importance of thorough airway evaluation at initial presentation and the need for validated screening protocols.
[Mh] Termos MeSH primário: Anormalidades Múltiplas
Cartilagem/anormalidades
Craniossinostoses/diagnóstico
Apneia Obstrutiva do Sono/epidemiologia
Traqueia/anormalidades
Doenças da Traqueia/congênito
[Mh] Termos MeSH secundário: Cartilagem/cirurgia
Criança
Pré-Escolar
Craniossinostoses/epidemiologia
Craniossinostoses/cirurgia
Feminino
Seres Humanos
Masculino
Morbidade/tendências
Estudos Retrospectivos
Apneia Obstrutiva do Sono/etiologia
Apneia Obstrutiva do Sono/cirurgia
Taxa de Sobrevida/tendências
Traqueia/cirurgia
Doenças da Traqueia/diagnóstico
Doenças da Traqueia/epidemiologia
Traqueostomia/métodos
Estados Unidos/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1097/SCS.0000000000003489


  6 / 31007 MEDLINE  
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[PMID]:29381987
[Au] Autor:Yan GW; Deng JF; Bhetuwal A; Yang GQ; Fu QS; Chen H; Hu N; Zeng H; Fan XP; Yan GW; Wu XL
[Ad] Endereço:Department of Radiology, Suining Central Hospital, Suining.
[Ti] Título:A case report and literature review of barium sulphate aspiration during upper gastrointestinal examination.
[So] Source:Medicine (Baltimore);96(47):e8821, 2017 Nov.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Even though barium sulphate aspiration during upper gastrointestinal examination is a well-known phenomenon, complication such as long-term lung injury and death may still occur. This may depend upon the concentration, amount, anatomy, or certain predisposing factors. PATIENT CONCERNS: A 47-year-old woman who had a barium swallow to screen for foreign body in esophagus. DIAGNOSES: Chest radiographs demonstrated massive barium sulphate depositions in her trachea and inferior lobe of right lung. INTERVENTIONS: A chest x-ray was done that revealed massive barium sulphate depositions in her trachea and lower lobe of right lung. As the patient did not have further complaints, she requested a transfer to West China Hospital of Sichuan University, the hospital being near her residence, for further treatment. She eventually recovered and was discharged after 1 week. OUTCOMES: There were 23 articles (22 English and 1 Chinese with 17 men and 11 women) included in the study. The risk factors of barium sulphate aspiration are dysphagia (10/28, 35.71%) followed by esophageal obstruction caused by tumor (5/28, 17.86%) and foreign body in esophagus (3/28, 10.71%). Infants (5/28, 17.86%) are also one of the high-risk population. Both the lungs were affected in most of the patients (21/28, 75%). Majority of the presentation in patients (21/28, 75%) were dyspnea, hypoxemia, acute respiratory distress syndrome (ARDS), or respiratory failure. Few patients (7/28, 25%) showed no symptoms or mild symptoms such as cough and fever. Barium sulphate aspiration can be life-threatening with a high risk of death (nearly 40%). LESSONS: When performing an upper gastrointestinal examination with barium sulphate, careful consideration of concentration and amount of barium sulphate and that of risk factors should be undertaken so as to avoid life-threatening aspiration.
[Mh] Termos MeSH primário: Sulfato de Bário/efeitos adversos
Meios de Contraste/efeitos adversos
Endoscopia do Sistema Digestório/efeitos adversos
Esôfago/diagnóstico por imagem
Corpos Estranhos/diagnóstico por imagem
Aspiração Respiratória/induzido quimicamente
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
Radiografia
Traqueia/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contrast Media); 25BB7EKE2E (Barium Sulfate)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008821


  7 / 31007 MEDLINE  
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[PMID]:29346372
[Au] Autor:van Mastrigt E; Zweekhorst S; Bol B; Tibboel J; van Rosmalen J; Samsom JN; Kroon AA; de Jongste JC; Reiss IKM; Post M; Pijnenburg MW
[Ad] Endereço:Division of Pediatric Pulmonology, Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands.
[Ti] Título:Ceramides in tracheal aspirates of preterm infants: Marker for bronchopulmonary dysplasia.
[So] Source:PLoS One;13(1):e0185969, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In an experimental mouse model we showed that ceramides play a role in the pathogenesis of bronchopulmonary dysplasia (BPD) and are a potential target for therapeutic intervention. We investigated whether ceramides are detectable in tracheal aspirates (TAs) of preterm infants and differ between infants with or without BPD. METHODS: Infants born ≤ 32 weeks of gestational age in need of mechanical ventilation in the first week of life were included. TAs were obtained directly after intubation and at day 1, 3, 5, 7, and 14. Ceramide concentrations were measured by tandem mass spectrometry. At 36 weeks postmenstrual age BPD was defined as having had ≥ 28 days supplemental oxygen. RESULTS: 122 infants were included, of which 14 died and 41 developed BPD. All infants showed an increase in ceramides after the first day of intubation. The ceramide profile differed significantly between preterm infants who did and did not develop BPD. However, the ceramide profile had no additional predictive value for BPD development over GA at birth, birth weight and total days of mechanical ventilation. CONCLUSIONS: Ceramides are measurable in TAs of preterm born infants and may be an early marker for BPD development.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Displasia Broncopulmonar/metabolismo
Ceramidas/metabolismo
Traqueia/metabolismo
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Recém-Nascido
Recém-Nascido Prematuro
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biomarkers); 0 (Ceramides)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185969


  8 / 31007 MEDLINE  
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[PMID]:29281691
[Au] Autor:Sellers ZM; Illek B; Figueira MF; Hari G; Joo NS; Sibley E; Souza-Menezes J; Morales MM; Fischer H; Wine JJ
[Ad] Endereço:Division of Pediatric Gastroenterology, Hepatolfifogy, and Nutrition, Stanford University, Palo Alto, CA, United States of America.
[Ti] Título:Impaired PGE2-stimulated Cl- and HCO3- secretion contributes to cystic fibrosis airway disease.
[So] Source:PLoS One;12(12):e0189894, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Airway mucociliary clearance (MCC) is an important defense mechanism against pulmonary infections and is compromised in cystic fibrosis (CF). Cl- and HCO3- epithelial transport are integral to MCC. During pulmonary infections prostaglandin E2 (PGE2) production is abundant. AIM: To determine the effect of PGE2 on airway Cl- and HCO3- secretion and MCC in normal and CF airways. METHODS: We examined PGE2 stimulated MCC, Cl- and HCO3- secretion using ferret trachea, human bronchial epithelial cell cultures (CFBE41o- with wildtype CFTR (CFBE41 WT) or homozygous F508del CFTR (CFBE41 CF) and human normal bronchial submucosal gland cell line (Calu-3) in Ussing chambers with or without pH-stat. RESULTS: PGE2 stimulated MCC in a dose-dependent manner and was partially impaired by CFTRinh-172. PGE2-stimulated Cl- current in ferret trachea was partially inhibited by CFTRinh-172, with niflumic acid eliminating the residual current. CFBE41 WT cell monolayers produced a robust Cl- and HCO3- secretory response to PGE2, both of which were completely inhibited by CFTRinh-172. CFBE41 CF cells exhibited no response to PGE2. In Calu-3 cells, PGE2 stimulated Cl- and HCO3- secretion. Cl- secretion was partially inhibited by CFTRinh-172, with additional inhibition by niflumic acid. HCO3- secretion was completely inhibited by CFTRinh-172. CONCLUSIONS: PGE2 stimulates bronchotracheal MCC and this response is decreased in CF. In CF airway, PGE2-stimulated Cl- and HCO3- conductance is impaired and may contribute to decreased MCC. There remains a CFTR-independent Cl- current in submucosal glands, which if exploited, could represent a means of improving airway Cl- secretion and MCC in CF.
[Mh] Termos MeSH primário: Bicarbonatos/metabolismo
Brônquios/efeitos dos fármacos
Cloretos/metabolismo
Fibrose Cística/metabolismo
Dinoprostona/farmacologia
Traqueia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Brônquios/patologia
Brônquios/secreção
Células Cultivadas
Seres Humanos
Técnicas In Vitro
Traqueia/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Bicarbonates); 0 (Chlorides); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171228
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189894


  9 / 31007 MEDLINE  
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[PMID]:27568138
[Au] Autor:Ragalie WS; Mitchell ME
[Ad] Endereço:Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
[Ti] Título:Advances in Surgical Treatment of Congenital Airway Disease.
[So] Source:Semin Thorac Cardiovasc Surg;28(1):62-8, 2016.
[Is] ISSN:1532-9488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tracheobronchomalacia (TBM) is frequently present in infants and children with congenital heart disease (CHD). Infants with CHD and TBM appear to do worse than those without TBM. The principle of operative intervention for TBM is to improve function of the airway and clinical status. When indicated, conventional surgical options include tracheostomy, aortopexy, tracheoplasty, and anterior tracheal suspension. There is no consensus on the optimal treatment of severe tracheobonchomalacia, which can be associated with a mortality rate as high as 80%. Congenital tracheal stenosis is also frequently associated with CHD (vascular rings, atrioventricular canal defects, and septal defects) and may require concomitant repair. Repair of tracheal stenosis is often associated with distal TBM. This article addresses new techniques that can be performed in corrective surgery for both TBM and congenital tracheal stenosis.
[Mh] Termos MeSH primário: Brônquios/cirurgia
Constrição Patológica/cirurgia
Procedimentos Cirúrgicos Torácicos
Traqueia/anormalidades
Traqueia/cirurgia
Traqueobroncomalácia/cirurgia
[Mh] Termos MeSH secundário: Brônquios/anormalidades
Brônquios/fisiopatologia
Constrição Patológica/diagnóstico
Constrição Patológica/mortalidade
Constrição Patológica/fisiopatologia
Difusão de Inovações
História do Século XX
História do Século XXI
Seres Humanos
Recuperação de Função Fisiológica
Índice de Gravidade de Doença
Procedimentos Cirúrgicos Torácicos/história
Procedimentos Cirúrgicos Torácicos/tendências
Traqueia/fisiopatologia
Traqueobroncomalácia/diagnóstico
Traqueobroncomalácia/mortalidade
Traqueobroncomalácia/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:HISTORICAL ARTICLE; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1703
[Cu] Atualização por classe:180126
[Lr] Data última revisão:
180126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160829
[St] Status:MEDLINE


  10 / 31007 MEDLINE  
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[PMID]:29216297
[Au] Autor:Yamashita J; Ohmoto M; Yamaguchi T; Matsumoto I; Hirota J
[Ad] Endereço:Department of Life Science and Technology, Graduate School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan.
[Ti] Título:Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice.
[So] Source:PLoS One;12(12):e0189340, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Transient receptor potential channel M5 (Trpm5)-expressing cells, such as sweet, umami, and bitter taste cells in the oropharyngeal epithelium, solitary chemosensory cells in the nasal respiratory epithelium, and tuft cells in the small intestine, that express taste-related genes function as chemosensory cells. Previous studies demonstrated that Skn-1a/Pou2f3, a POU homeodomain transcription factor is expressed in these Trpm5-expressing chemosensory cells, and is necessary for their generation. Trpm5-expressing cells have recently been found in trachea, auditory tube, urethra, thymus, pancreatic duct, stomach, and large intestine. They are considered to be involved in protective responses to potential hazardous compounds as Skn-1a-dependent bitter taste cells, respiratory solitary chemosensory cells, and intestinal tuft cells are. In this study, we examined the expression and function of Skn-1a/Pou2f3 in Trpm5-expressing cells in trachea, auditory tube, urethra, thymus, pancreatic duct, stomach, and large intestine. Skn-1a/Pou2f3 is expressed in a majority of Trpm5-expressing cells in all tissues examined. In Skn-1a/Pou2f3-deficient mice, the expression of Trpm5 as well as marker genes for Trpm5-expressing cells were absent in all tested tissues. Immunohistochemical analyses demonstrated that two types of microvillous cells exist in trachea, urethra, and thymus, Trpm5-positive and Trpm5-negative cells. In Skn-1a/Pou2f3-deficient mice, a considerable proportion of Trpm5-negative and villin-positive microvillous cells remained present in these tissues. Thus, we propose that Skn-1a/Pou2f3 is the master regulator for the generation of the Trpm5-expressing microvillous cells in multiple tissues.
[Mh] Termos MeSH primário: Fatores de Transcrição de Octâmero/fisiologia
Canais de Cátion TRPM/fisiologia
[Mh] Termos MeSH secundário: Animais
Sistema Digestório/citologia
Sistema Digestório/metabolismo
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Traqueia/citologia
Traqueia/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Octamer Transcription Factors); 0 (Pou2f3 protein, mouse); 0 (TRPM Cation Channels); 0 (Trpm5 protein, mouse)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180122
[Lr] Data última revisão:
180122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171208
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189340



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