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[PMID]:28469101
[Au] Autor:Wang L; Mei XL
[Ad] Endereço:Department of Dermatology, Allergy and Clinical Immunology Centre, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
[Ti] Título:Retrospective Analysis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in 88 Chinese Patients.
[So] Source:Chin Med J (Engl);130(9):1062-1068, 2017 May 05.
[Is] ISSN:0366-6999
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening diseases with high mortality rates. This study was designed to analyze the pathogenic factors, clinical manifestations, complications, treatment, and prognosis of SJS/TEN and to explore the differences between surviving and deceased patients. METHODS: SJS/TEN patients admitted to Beijing Friendship Hospital from January 2006 to December 2015 were included in the study. Patients' data were retrospectively analyzed. Comparative studies were performed on the survival group and the deceased group, and Fisher's exact probability test was used for statistical analysis. RESULTS: Among the 88 patients included, 40 (45.5%) were male with a mean age of 45 ± 18 years. Forty-eight (54.5%) had SJS, 34 (38.6%) had SJS/TEN, and 6 (6.8%) had TEN. Fifty-three (60.2%) cases were caused by medications, mainly antibiotics (n = 24) followed by traditional Chinese medicines (n = 7). Forty-two cases (47.7%) developed visceral damage. Eighty-two patients improved or recovered and were discharged from hospital, and six patients died. Comparative studies on the survival group and the deceased group showed that the presence of malignant tumor ( χ2 = 27.969,P < 0.001), connective tissue diseases ( χ2 = 9.187, P= 0.002), previous abnormal liver/kidney functions ( χ2 = 6.006, P= 0.014), heart rate >100 times/min ( χ2 = 6.347, P= 0.012), detached skin area >20% ( χ2 = 5.594, P= 0.018), concurrent mucosal involvement at the mouth, eyes, and external genitals ( χ2 = 4.945, P= 0.026), subsequent accompanying liver/kidney damage ( χ2 = 11.839, P= 0.001, and χ2 = 36.302,P < 0.001, respectively), and SCORTEN score >2 ( χ2 = 37.148,P < 0.001) increased the risk of death. CONCLUSIONS: SJS/TEN is mainly caused by medications, and nearly half of patients develop visceral damage. Multiple factors increase the mortality risk.
[Mh] Termos MeSH primário: Síndrome de Stevens-Johnson/metabolismo
Síndrome de Stevens-Johnson/patologia
[Mh] Termos MeSH secundário: Adulto
Antibacterianos/uso terapêutico
Doenças do Tecido Conjuntivo/metabolismo
Doenças do Tecido Conjuntivo/patologia
Olho/patologia
Feminino
Genitália/patologia
Seres Humanos
Rim/metabolismo
Rim/patologia
Fígado/metabolismo
Fígado/patologia
Masculino
Meia-Idade
Boca/patologia
Estudos Retrospectivos
Pele/metabolismo
Pele/patologia
Síndrome de Stevens-Johnson/tratamento farmacológico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.4103/0366-6999.204929


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[PMID]:29406058
[Au] Autor:Yura E; Flury S
[Ad] Endereço:Department of Urology, Northwestern University, Tarry Building Room 16-703, 300 East Superior Street, Chicago, IL 60611, USA.
[Ti] Título:Cutaneous Lesions of the External Genitalia.
[So] Source:Med Clin North Am;102(2):279-300, 2018 Mar.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Individuals with cutaneous diseases of the external genitalia often initially present to their primary care provider. When present, these conditions may be associated with considerable physical symptoms and psychological distress. Dermatoses affecting the genitals may be of infectious, inflammatory, or neoplastic cause, and can be processes confined to the genitalia or a manifestation of a more widespread dermatologic condition. This article provides a guide to recognizing and managing common genital dermatoses and when to refer for specialist opinion.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/diagnóstico
Doenças dos Genitais Masculinos/diagnóstico
Genitália/patologia
Dermatopatias/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Doenças dos Genitais Femininos/etiologia
Doenças dos Genitais Masculinos/etiologia
Seres Humanos
Masculino
Pênis/patologia
Escroto/patologia
Dermatopatias/etiologia
Vulva/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:28743441
[Au] Autor:Matthes ADCS; Zucca Matthes G
[Ad] Endereço:Gynecology and Obstetrics, Medical School at the University of Ribeirão Preto São Paulo, Ribeirão Preto, Brazil. Electronic address: amatthes@unaerp.br.
[Ti] Título:Quality of life of menopausal women with genital urinary menopause syndrome.
[So] Source:Am J Obstet Gynecol;217(5):624, 2017 11.
[Is] ISSN:1097-6868
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Menopausa
Qualidade de Vida
[Mh] Termos MeSH secundário: Feminino
Genitália
Seres Humanos
Perimenopausa
Síndrome
[Pt] Tipo de publicação:LETTER; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


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[PMID]:28739831
[Au] Autor:Naglak EK; Morrison SG; Morrison RP
[Ad] Endereço:Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
[Ti] Título:Neutrophils Are Central to Antibody-Mediated Protection against Genital Chlamydia.
[So] Source:Infect Immun;85(10), 2017 Oct.
[Is] ISSN:1098-5522
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Determining the effector populations involved in humoral protection against genital chlamydia infection is crucial to development of an effective chlamydial vaccine. Antibody has been implicated in protection studies in multiple animal models, and we previously showed that the passive transfer of immune serum alone does not confer immunity in the mouse. Using the model of genital infection, we demonstrate a protective role for both -specific immunoglobulin G (IgG) and polymorphonuclear neutrophils and show the importance of an antibody/effector cell interaction in mediating humoral immunity. While neutrophils were found to contribute significantly to antibody-mediated protection , natural killer (NK) cells were dispensable for protective immunity. Furthermore, gamma interferon (IFN-γ)-stimulated primary peritoneal neutrophils (PPNs) killed chlamydiae in an antibody-dependent manner. The results from this study support the view that an IFN-γ-activated effector cell population cooperates with antibody to protect against genital chlamydia and establish neutrophils as a key effector cell in this response.
[Mh] Termos MeSH primário: Anticorpos Antibacterianos/imunologia
Infecções por Chlamydia/imunologia
Chlamydia muridarum/imunologia
Doenças dos Genitais Femininos/imunologia
Genitália/imunologia
Imunidade Humoral
Neutrófilos/imunologia
[Mh] Termos MeSH secundário: Animais
Anticorpos Antibacterianos/sangue
Linfócitos T CD4-Positivos/imunologia
Infecções por Chlamydia/prevenção & controle
Feminino
Doenças dos Genitais Femininos/prevenção & controle
Genitália/microbiologia
Imunoglobulina G/sangue
Imunoglobulina G/imunologia
Interferon gama/imunologia
Interferon gama/farmacologia
Células Matadoras Naturais/imunologia
Camundongos
Neutrófilos/efeitos dos fármacos
Doenças Sexualmente Transmissíveis/imunologia
Doenças Sexualmente Transmissíveis/microbiologia
Doenças Sexualmente Transmissíveis/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Bacterial); 0 (Immunoglobulin G); 82115-62-6 (Interferon-gamma)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE


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[PMID]:28711653
[Au] Autor:Johnston C; Magaret A; Roychoudhury P; Greninger AL; Cheng A; Diem K; Fitzgibbon MP; Huang ML; Selke S; Lingappa JR; Celum C; Jerome KR; Wald A; Koelle DM
[Ad] Endereço:Department of Medicine, University of Washington, USA; Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, USA. Electronic address: cjohnsto@uw.edu.
[Ti] Título:Highly conserved intragenic HSV-2 sequences: Results from next-generation sequencing of HSV-2 U and U regions from genital swabs collected from 3 continents.
[So] Source:Virology;510:90-98, 2017 Oct.
[Is] ISSN:1096-0341
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Understanding the variability in circulating herpes simplex virus type 2 (HSV-2) genomic sequences is critical to the development of HSV-2 vaccines. METHODS: Genital lesion swabs containing ≥ 10 log copies HSV DNA collected from Africa, the USA, and South America underwent next-generation sequencing, followed by K-mer based filtering and de novo genomic assembly. Sites of heterogeneity within coding regions in unique long and unique short (U _U ) regions were identified. Phylogenetic trees were created using maximum likelihood reconstruction. RESULTS: Among 46 samples from 38 persons, 1468 intragenic base-pair substitutions were identified. The maximum nucleotide distance between strains for concatenated U U segments was 0.4%. Phylogeny did not reveal geographic clustering. The most variable proteins had non-synonymous mutations in < 3% of amino acids. CONCLUSIONS: Unenriched HSV-2 DNA can undergo next-generation sequencing to identify intragenic variability. The use of clinical swabs for sequencing expands the information that can be gathered directly from these specimens.
[Mh] Termos MeSH primário: Sequência Conservada
Genes Virais
Variação Genética
Herpes Genital/virologia
Herpesvirus Humano 2/classificação
Herpesvirus Humano 2/genética
[Mh] Termos MeSH secundário: África
Análise por Conglomerados
Genitália/virologia
Sequenciamento de Nucleotídeos em Larga Escala
Filogenia
Homologia de Sequência
América do Sul
Estados Unidos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170829
[Lr] Data última revisão:
170829
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


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[PMID]:28711085
[Au] Autor:Miller CJ; Shin TM; Sobanko JF; Sharkey JM; Grunyk JW; Elenitsas R; Chu EY; Capell BC; Ming ME; Etzkorn JR
[Ad] Endereço:Department of Dermatology, University of Pennsylvania Health System, Philadelphia, Pennsylvania. Electronic address: christopher.miller@uphs.upenn.edu.
[Ti] Título:Risk factors for positive or equivocal margins after wide local excision of 1345 cutaneous melanomas.
[So] Source:J Am Acad Dermatol;77(2):333-340.e1, 2017 Aug.
[Is] ISSN:1097-6787
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Positive or equivocal margins after wide local excision (WLE) complicate surgical management of cutaneous melanoma. OBJECTIVE: To identify the frequency of and risk factors for positive or equivocal margins after WLE of cutaneous melanoma. METHODS: Retrospective, single-center, cross-sectional study of 1345 consecutive melanomas treated with WLE. RESULTS: The overall frequency of positive or equivocal margins was 4.2% (56/1345), ranging from 2.2% to 22.6%, depending on the size of the surgical margins, patient characteristics, biopsy history, and the clinicopathology of the melanoma. In descending order, independent risk factors associated with the greatest odds for positive or equivocal margins after multivariate analysis were noncompliance with recommended surgical margins (odds ratio [OR] 5.57, P = .002); anatomic location on the head, neck, hands, feet, genitals, or pretibial leg (OR 5.07, P < .001); histologic regression (OR 2.78, P = .007); in situ melanoma (OR 2.27, P = .011); multiple biopsies at the tumor site before WLE (OR 1.92 [per biopsy], P = .004); and increasing age (OR 1.049 [per year], P < .001). LIMITATIONS: This was a single-site, retrospective observational study. CONCLUSIONS: Clinicopathologic factors, especially location in cosmetically or functionally sensitive areas and noncompliance with recommended surgical margins, identified melanomas at increased risk for positive or equivocal margins after WLE.
[Mh] Termos MeSH primário: Neoplasias de Cabeça e Pescoço/cirurgia
Melanoma/cirurgia
Neoplasias Cutâneas/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Estudos Transversais

Genitália
Fidelidade a Diretrizes
Mãos
Seres Humanos
Perna (Membro)
Margens de Excisão
Melanoma/patologia
Meia-Idade
Neoplasia Residual
Guias de Prática Clínica como Assunto
Estudos Retrospectivos
Fatores de Risco
Neoplasias Cutâneas/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170825
[Lr] Data última revisão:
170825
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170717
[St] Status:MEDLINE


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[PMID]:28678866
[Au] Autor:Fernandes Martins MJ; Hunt G; Lockwood R; Swaddle JP; Horne DJ
[Ad] Endereço:Department of Paleobiology, National Museum of Natural History, Smithsonian Institution, Washington DC, United States of America.
[Ti] Título:Correlation between investment in sexual traits and valve sexual dimorphism in Cyprideis species (Ostracoda).
[So] Source:PLoS One;12(7):e0177791, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Assessing the long-term macroevolutionary consequences of sexual selection has been hampered by the difficulty of studying this process in the fossil record. Cytheroid ostracodes offer an excellent system to explore sexual selection in the fossil record because their readily fossilized carapaces are sexually dimorphic. Specifically, males are relatively more elongate than females in this superfamily. This sexual shape difference is thought to arise so that males carapaces can accommodate their very large copulatory apparatus, which can account for up to one-third of body volume. Here we test this widely held explanation for sexual dimorphism in cytheroid ostracodes by correlating investment in male genitalia, a trait in which sexual selection is seen as the main evolutionary driver, with sexual dimorphism of carapace in the genus Cyprideis. We analyzed specimens collected in the field (C. salebrosa, USA; C. torosa, UK) and from collections of the National Museum of Natural History, Washington, DC (C. mexicana). We digitized valve outlines in lateral view to obtain measures of size (valve area) and shape (elongation, measured as length to height ratio), and obtained several dimensions from two components of the hemipenis: the muscular basal capsule, which functions as a sperm pump, and the section that includes the intromittent organ (terminal extension). In addition to the assessment of this primary sexual trait, we also quantified two dimensions of the male secondary sexual trait-where the transformed right walking leg functions as a clasping organ during mating. We also measured linear dimensions from four limbs as indicators of overall (soft-part) body size, and assessed allometry of the soft anatomy. We observed significant correlations in males between valve size, but not elongation, and distinct structural parts of the hemipenis, even after accounting for their shared correlation with overall body size. We also found weak but significant positive correlation between valve elongation and the degree of sexual dimorphism of the walking leg, but only in C. torosa. The correlation between the hemipenis parts, especially basal capsule size and male valve size dimorphism suggests that sexual selection on sperm size, quantity, and/or efficiency of transfer may drive sexual size dimorphism in these species, although we cannot exclude other aspects of sexual and natural selection.
[Mh] Termos MeSH primário: Crustáceos/fisiologia
Fósseis
Genitália/fisiologia
Caracteres Sexuais
Comportamento Sexual Animal/fisiologia
[Mh] Termos MeSH secundário: Animais
Tamanho Corporal
Crustáceos/anatomia & histologia
Crustáceos/classificação
Feminino
Genitália/anatomia & histologia
Masculino
Tamanho do Órgão
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177791


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[PMID]:28656018
[Au] Autor:Hastings AK; Fikrig E
[Ad] Endereço:Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT.
[Ti] Título:Zika Virus and Sexual Transmission: A New Route of Transmission for Mosquito-borne Flaviviruses
.
[So] Source:Yale J Biol Med;90(2):325-330, 2017 Jun.
[Is] ISSN:1551-4056
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Beginning in 2015, concern over a new global epidemic has spread in the media, governmental agencies, legislative bodies and the public at large. This newly emerging threat has been reported to cause symptoms ranging from mild fever, rash, and body aches, to severe birth defects and acute onset paralysis. The causative agent of this disease, Zika virus, is closely related to two other important human pathogens, dengue and West Nile Virus (WNV), but has some distinguishing features that has raised alarms from the scientific community. Like its two close relatives, this virus is a member of the Flaviviridae family, a class of single stranded RNA viruses with a positive sense genome and is spread primarily via the bite of an infected mosquito. However, this virus has demonstrated another route of transmission that is particularly concerning for people outside of the regions where the main mosquito vector for this virus is present. Sexual transmission of Zika virus has been increasingly reported, from both infected males and females to their partner, which has resulted in the World Health Organization (WHO) and the Center for Disease Control (CDC) issuing warnings to those living in or travelling to areas of Zika transmission to practice abstinence and/or avoid unprotected sexual contact for up to six months after infection with this virus. This perspective will outline the evidence for sexual transmission and persistence of viral infection in semen and vaginal secretions as well as review the animal models for sexual transmission of Zika virus.
[Mh] Termos MeSH primário: Doenças Virais Sexualmente Transmissíveis/transmissão
Infecção pelo Zika virus/transmissão
Zika virus/fisiologia
[Mh] Termos MeSH secundário: Aedes/virologia
Animais
Modelos Animais de Doenças
Feminino
Genitália/virologia
Seres Humanos
Masculino
Camundongos
Mosquitos Vetores/virologia
Doenças Virais Sexualmente Transmissíveis/virologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171011
[Lr] Data última revisão:
171011
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE


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[PMID]:28610328
[Au] Autor:Volynkin AV; Cerný K; Dubatolov VV
[Ad] Endereço:Altai State University, Lenina str. 61, RF-656049, Barnaul, Russia; Tomsk State University, Institute of Biology, Ecology, Soil Science, Agriculture and Forestry, Lenina Avenue, 36, RF-634050, Tomsk, Russia.. volynkin_a@mail.ru.
[Ti] Título:A new Cyana Walker, 1854 from Vietnam (Lepidoptera, Erebidae, Arctiinae).
[So] Source:Zootaxa;4269(3):438-446, 2017 05 23.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:A new species of the genus Cyana Walker, 1854, C. aurantifascia Volynkin, Cerný & Dubatolov, sp. nov. is described from Vietnam. The Cyana dohertyi and Cyana phaedra species-groups are established. The new species belongs to the C. dohertyi species-group. Diagnostic comparisons are made with species of similar habitus belonging to the same and to other species-group. Adults, male and female genitalia of the new and related species are illustrated.
[Mh] Termos MeSH primário: Mariposas
[Mh] Termos MeSH secundário: Animais
Feminino
Genitália
Masculino
Vietnã
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4269.3.7


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[PMID]:28610285
[Au] Autor:Beccacece HM; Zapata AI
[Ad] Endereço:Centro de Investigaciones Entomológicas de Córdoba, Instituto de Investigaciones Biológicas y Tecnológicas (CONICET-UNC). Cátedra Diversidad Animal I. Grupo de Investigación y Conservación de Lepidópteros de Argentina y Museo de Zoología, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba.. beccacecehernan@gmail.com.
[Ti] Título:Taxonomic changes of some neotropical species of Arctiini Leach (Lepidoptera: Erebidae: Arctiinae).
[So] Source:Zootaxa;4272(3):421-429, 2017 May 30.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Arctiini (Lepidoptera, Erebidae, Arctiinae) is the most speciose tribe of tiger moths. In this study, the taxonomy of some Neotropical species of this tribe is reviewed based on habitus and, in some cases, genitalia of type specimens. Lectotypes are designated for two names. Four new combinations are proposed: Agaraea sericeum (Zerny, 1931) comb. n., Biturix nigrostriata (Rothschild, 1909) comb. n., Carales fasciatus (Rothschild, 1909) comb. n. and Opharus pallida (Dognin, 1910) comb. n. Six new synonymies are proposed: Agaraea nigrotuberculata Bryk, 1953 (=Agaraea klagesi (Rothschild, 1909)), Opharus ochracea Joicey & Talbot, 1918 and Pelochyta fergusoni Watson & Goodger, 1986 (=Opharus pallida (Dognin, 1910)), Melese flavescens Joicey & Talbot, 1918 (=Melese paranensis Dognin, 1911), Leucanopsis infucata (Berg, 1882) (=Pareuchaetes aurata aurata (Butler, 1875)) and Tessellota pura Breyer, 1957 (=Tessellota cancellata (Burmeister, 1878)). Moreover, Opharus ochracea Joicey & Talbot, 1918 comb. rev. is returned to the original genus. For each rearrangement, both remarks and information about type specimens are provided.
[Mh] Termos MeSH primário: Mariposas
[Mh] Termos MeSH secundário: Animais
Genitália
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170615
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4272.3.7



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