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  1 / 7659 MEDLINE  
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[PMID]:28464913
[Au] Autor:Nakabuye B; Bahendeka S; Byaruhanga R
[Ad] Endereço:Department Obstetrics and Gynaecology, St. Francis Hospital Nsambya, P.O.Box 7146, Kampala, Uganda. lizanakabuye@yahoo.com.
[Ti] Título:Prevalence of hyperglycaemia first detected during pregnancy and subsequent obstetric outcomes at St. Francis Hospital Nsambya.
[So] Source:BMC Res Notes;10(1):174, 2017 May 02.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Women with hyperglycaemia detected during pregnancy are at greater risk for adverse pregnancy outcomes. Data on hyperglycaemia in pregnancy in sub-Saharan Africa is scanty and varied depending on the populations studied and the methodologies used to define hyperglycaemia in pregnancy. With the recent 2013 World Health Organisation (WHO) diagnostic criteria and classification, there is yet no sufficient data on the prevalence of hyperglycaemia in sub-Saharan Africa. The objective was to determine the prevalence of Hyperglycaemia first detected during pregnancy and subsequent obstetric outcomes among patients attending antenatal care (ANC) at St. Francis Hospital Nsambya. METHODS: A prospective cohort study. All women with no history of diabetes mellitus attending at or after 24 weeks gestation were eligible to participate in the study. Participants underwent a standard 75 g oral glucose tolerance test (OGTT) after an informed written consent. The primary outcome was diagnosis of hyperglycaemia. Enrolled participants were followed up to delivery to assess obstetric outcomes (secondary outcomes were birth weight, neonatal admission, maternal genital trauma, delivery mode, neonatal and maternal status at discharge). RESULTS: 251 women were screened between December 2013 and February 2014. The prevalence of hyperglycaemia first detected in pregnancy was 31.9%. We found 23.8 % of women with hyperglycaemia had no known risk factor. Macrosomia was the only obstetric outcome that was significantly associated with hyperglycaemia. CONCLUSION: The prevalence of hyperglycaemia first detected in pregnancy was high in the studied population. Clinicians, therefore, should become more vigilant to screen for the condition. Selective screening may miss 23.8% of pregnant women with hyperglycaemia. However the cost/benefit implications of screening strategy and the recent 2013 WHO diagnostic criteria need to be studied in our setting.
[Mh] Termos MeSH primário: Diabetes Gestacional/epidemiologia
Macrossomia Fetal/epidemiologia
Hiperglicemia/epidemiologia
Lacerações/epidemiologia
[Mh] Termos MeSH secundário: Adulto
Diabetes Gestacional/sangue
Feminino
Macrossomia Fetal/sangue
Genitália Feminina/lesões
Teste de Tolerância a Glucose
Seres Humanos
Hiperglicemia/sangue
Nascimento Vivo/epidemiologia
Gravidez
Cuidado Pré-Natal
Diagnóstico Pré-Natal/estatística & dados numéricos
Prevalência
Estudos Prospectivos
Natimorto/epidemiologia
Uganda/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2493-0


  2 / 7659 MEDLINE  
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[PMID]:28746373
[Au] Autor:Carroll T; Lo M; Lanteri M; Dutra J; Zarbock K; Silveira P; Rourke T; Ma ZM; Fritts L; O'Connor S; Busch M; Miller CJ
[Ad] Endereço:Center for Comparative Medicine University of California, Davis, Davis, California, United States of America.
[Ti] Título:Zika virus preferentially replicates in the female reproductive tract after vaginal inoculation of rhesus macaques.
[So] Source:PLoS Pathog;13(7):e1006537, 2017 Jul.
[Is] ISSN:1553-7374
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Zika virus (ZIKV) is a mosquito-transmitted virus that can cause severe defects in an infected fetus. ZIKV is also transmitted by sexual contact, although the relative importance of sexual transmission is unclear. To better understand the role of sexual transmission in ZIKV pathogenesis, a nonhuman primate (NHP) model of vaginal transmission was developed. ZIKV was readily transmitted to mature cycling female rhesus macaque (RM) by vaginal inoculation with 104-106 plaque-forming units (PFU). However, there was variability in susceptibility between the individual RM with 1->8 vaginal inoculations required to establish infection. After treatment with Depoprovera, a widely used contraceptive progestin, two RM that initially resisted 8 vaginal ZIKV inoculations became infected after one ZIKV inoculation. Thus, Depoprovera seemed to enhance susceptibility to vaginal ZIKV transmission. Unexpectedly, the kinetics of virus replication and dissemination after intravaginal ZIKV inoculation were markedly different from RM infected with ZIKV by subcutaneous (SQ) virus inoculation. Several groups have reported that after SQ ZIKV inoculation vRNA is rapidly detected in blood plasma with vRNA less common in urine and saliva and only rarely detected in female reproductive tract (FRT) secretions. In contrast, in vaginally inoculated RM, plasma vRNA is delayed for several days and ZIKV replication in, and vRNA shedding from, the FRT was found in all 6 animals. Further, after intravaginal transmission ZIKV RNA shedding from FRT secretions was detected before or simultaneously with plasma vRNA, and persisted for at least as long. Thus, ZIKV replication in the FRT was independent of, and often preceded virus replication in the tissues contributing to plasma vRNA. These results support the conclusion that ZIKV preferentially replicates in the FRT after vaginal transmission, but not after SQ transmission, and raise the possibility that there is enhanced fetal infection and pathology after vaginal ZIKV transmission compared to a mosquito transmitted ZIKV.
[Mh] Termos MeSH primário: Vagina/virologia
Infecção pelo Zika virus/virologia
Zika virus/fisiologia
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Feminino
Genitália Feminina/virologia
Macaca mulatta
Replicação Viral
Eliminação de Partículas Virais
Zika virus/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171213
[Lr] Data última revisão:
171213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1371/journal.ppat.1006537


  3 / 7659 MEDLINE  
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[PMID]:28464390
[Au] Autor:Farias NE; Spivak ED; Luppi TA
[Ad] Endereço:Instituto de Investigaciones Marinas y Costeras (IIMyC), Consejo Nacional de investigaciones Científicas y Tecnológicas (CONICET), Universidad Nacional de Mar del Plata, Departamento de Biología, CC 1260, Mar del Plata, 7600, Argentina.
[Ti] Título:Functional morphology of the female reproductive system of a crab with highly extensible seminal receptacles and extreme sperm storage capacity.
[So] Source:J Morphol;278(7):919-935, 2017 Jul.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We studied the functional morphology of the female reproductive system of the purple stone crab Danielethus crenulatus. The most remarkable feature is the relative storage capacity and extensibility of the seminal receptacles. These receptacles are a pair of simple sacs that lack internal structures dividing the internal lumen. Differences in seminal receptacle size and contents are accompanied by conspicuous changes in receptacle lining at a tissue level. Full seminal receptacles contain discrete sperm masses formed by hardened fluid and densely packed spermatophores. Different sperm masses are likely from different mates and their stratified disposition within the seminal receptacles is compatible with rival sperm displacement and last sperm precedence. Additionally, the anatomical structure of the vulva and vagina suggest active female control over copula. We discuss our results in the general context of sperm storage in brachyurans and the implications for the mating system of this species.
[Mh] Termos MeSH primário: Braquiúros/anatomia & histologia
Braquiúros/fisiologia
Genitália Feminina/anatomia & histologia
Genitália Feminina/fisiologia
Glândulas Seminais/fisiologia
Espermatozoides/fisiologia
[Mh] Termos MeSH secundário: Animais
Feminino
Genitália Feminina/citologia
Masculino
Reprodução
Comportamento Sexual Animal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.20685


  4 / 7659 MEDLINE  
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[PMID]:29065798
[Au] Autor:Young AN; Moyle-Heyrman G; Kim JJ; Burdette JE
[Ad] Endereço:1 College of Pharmacy, University of Illinois, Chicago, IL 60607, USA.
[Ti] Título:Microphysiologic systems in female reproductive biology.
[So] Source:Exp Biol Med (Maywood);242(17):1690-1700, 2017 Nov.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a tissue-tissue interface or physical forces like fluid sheer stress. The female reproductive system is a series of interconnected organs that are necessary to produce eggs, support embryo development and female health, and impact the functioning of non-reproductive tissues throughout the body. Despite its importance, the human reproductive tract has received less attention than other organ systems, such as the liver and kidney, in terms of modeling with MPS. In this review, we discuss current gaps in the field and areas for technological advancement through the application of MPS. We explore current MPS research in female reproductive biology, including fertilization, pregnancy, and female reproductive tract diseases, with a focus on their clinical applications. Impact statement This review discusses existing microphysiologic systems technology that may be applied to study of the female reproductive tract, and those currently in development to specifically investigate gametes, fertilization, embryo development, pregnancy, and diseases of the female reproductive tract. We focus on the clinical applicability of these new technologies in fields such as assisted reproductive technologies, drug testing, disease diagnostics, and personalized medicine.
[Mh] Termos MeSH primário: Desenvolvimento Embrionário/fisiologia
Doenças dos Genitais Femininos/patologia
Genitália Feminina/fisiopatologia
Microfluídica/métodos
[Mh] Termos MeSH secundário: Técnicas de Cultura de Células
Feminino
Seres Humanos
Gravidez
Técnicas de Reprodução Assistida
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1177/1535370217697386


  5 / 7659 MEDLINE  
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[PMID]:28842113
[Au] Autor:Addley H; Moyle P; Freeman S
[Ad] Endereço:Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, Hills Road, Cambridge CB2 0QQ, UK.
[Ti] Título:Diffusion-weighted imaging in gynaecological malignancy.
[So] Source:Clin Radiol;72(11):981-990, 2017 Nov.
[Is] ISSN:1365-229X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Diffusion weighted imaging (DWI) has become an essential part of the gynaecological magnetic resonance imaging (MRI) protocol. DWI is used as an adjunct to conventional MRI sequences and has been shown to improve reporting accuracy in the imaging of gynaecological malignancy. In this review, we discuss the role of DWI in the diagnosis, staging, and assessment of treatment response of endometrial, cervical, and ovarian cancer. We also review the role of DWI in the assessment of the sonographically indeterminate ovarian lesion. Further, we highlight potential pitfalls that can beset the accurate interpretation of DWI in patients with gynaecological malignancy.
[Mh] Termos MeSH primário: Imagem de Difusão por Ressonância Magnética/métodos
Neoplasias dos Genitais Femininos/diagnóstico por imagem
[Mh] Termos MeSH secundário: Feminino
Genitália Feminina/diagnóstico por imagem
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170827
[St] Status:MEDLINE


  6 / 7659 MEDLINE  
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[PMID]:28827393
[Au] Autor:Sankar A; Kooistra SM; Gonzalez JM; Ohlsson C; Poutanen M; Helin K
[Ad] Endereço:Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen 2200, Denmark.
[Ti] Título:Maternal expression of the histone demethylase Kdm4a is crucial for pre-implantation development.
[So] Source:Development;144(18):3264-3277, 2017 09 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Regulation of chromatin composition through post-translational modifications of histones contributes to transcriptional regulation and is essential for many cellular processes, including differentiation and development. KDM4A (JMJD2A) is a lysine demethylase with specificity towards di- and tri-methylated lysine 9 and lysine 36 of histone H3 (H3K9me2/me3 and H3K36me2/me3). Here, we report that as a maternal factor plays a key role in embryo survival and is vital for female fertility. female mice ovulate normally with comparable fertilization but poor implantation rates, and cannot support healthy transplanted embryos to term. This is due to a role for Kdm4a in uterine function, where its loss causes reduced expression of key genes involved in ion transport, nutrient supply and cytokine signalling, which impact embryo survival. In addition, a significant proportion of Kdm4a-deficient oocytes displays a poor intrinsic ability to develop into blastocysts. These embryos cannot compete with healthy embryos for implantation , highlighting as a maternal effect gene. Thus, our study dissects an important dual role for maternal Kdm4a in determining faithful early embryonic development and the implantation process.
[Mh] Termos MeSH primário: Implantação do Embrião
Histona Desmetilases/metabolismo
[Mh] Termos MeSH secundário: Animais
Citocinas/metabolismo
Implantação do Embrião/genética
Embrião de Mamíferos/metabolismo
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Genitália Feminina/metabolismo
Infertilidade Feminina/genética
Infertilidade Feminina/patologia
Camundongos Endogâmicos C57BL
Camundongos Knockout
Gravidez
Transdução de Sinais
Útero/metabolismo
Zigoto/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); EC 1.14.11.- (Histone Demethylases); EC 1.14.11.- (JMJD2A protein, mouse)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1242/dev.155473


  7 / 7659 MEDLINE  
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[PMID]:28760882
[Au] Autor:Marlin R; Nugeyre MT; Tchitchek N; Parenti M; Hocini H; Benjelloun F; Cannou C; Dereuddre-Bosquet N; Levy Y; Barré-Sinoussi F; Scarlatti G; Le Grand R; Menu E
[Ad] Endereço:Immunologie des Infections Virales et des Maladies Auto-immunes (ImVA)/Infrastructure Nationale pour la Modélisation des Maladies Infectieuses Humaines et les Thérapies Innovantes (IDMIT)/Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA)/Direction de la Recherche Fondamentale (DRF
[Ti] Título:Modified Vaccinia Virus Ankara Vector Induces Specific Cellular and Humoral Responses in the Female Reproductive Tract, the Main HIV Portal of Entry.
[So] Source:J Immunol;199(5):1923-1932, 2017 Sep 01.
[Is] ISSN:1550-6606
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The female reproductive tract (FRT) is one of the major mucosal invasion sites for HIV-1. This site has been neglected in previous HIV-1 vaccine studies. Immune responses in the FRT after systemic vaccination remain to be characterized. Using a modified vaccinia virus Ankara (MVA) as a vaccine model, we characterized specific immune responses in all compartments of the FRT of nonhuman primates after systemic vaccination. Memory T cells were preferentially found in the lower tract (vagina and cervix), whereas APCs and innate lymphoid cells were mainly located in the upper tract (uterus and fallopian tubes). This compartmentalization of immune cells in the FRT was supported by transcriptomic analyses and a correlation network. Polyfunctional MVA-specific CD8 T cells were detected in the blood, lymph nodes, vagina, cervix, uterus, and fallopian tubes. Anti-MVA IgG and IgA were detected in cervicovaginal fluid after a second vaccine dose. Thus, systemic vaccination with an MVA vector elicits cellular and Ab responses in the FRT.
[Mh] Termos MeSH primário: Células Apresentadoras de Antígenos/imunologia
Genitália Feminina/imunologia
HIV-1/patogenicidade
Infecções do Sistema Genital/imunologia
Linfócitos T/imunologia
Vírus Vaccinia/imunologia
Vaccinia/imunologia
Vacinas Virais/imunologia
[Mh] Termos MeSH secundário: Vacinas contra a AIDS/imunologia
Animais
Anticorpos Antivirais/metabolismo
Antígenos Virais/imunologia
Células Cultivadas
Transmissão de Doença Infecciosa
Feminino
Vetores Genéticos/genética
Genitália Feminina/virologia
Seres Humanos
Imunidade Celular
Imunidade Humoral
Imunoglobulina A/metabolismo
Imunoglobulina G/metabolismo
Memória Imunológica
Primatas
Vacinação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (AIDS Vaccines); 0 (Antibodies, Viral); 0 (Antigens, Viral); 0 (Immunoglobulin A); 0 (Immunoglobulin G); 0 (Viral Vaccines)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.4049/jimmunol.1700320


  8 / 7659 MEDLINE  
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[PMID]:28750613
[Au] Autor:Okeji MC; Agwuna KK; Ihudiebube-Splendor CN; Izge IY; Ekuma KK; Emeter JO
[Ad] Endereço:Department of Medical Radiography and Radiological Sciences, Faculty of Health Sciences and Technology, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria. mark.okeji@unn.edu.ng.
[Ti] Título:Transvaginal Sonography: perception and attitude of Nigerian women.
[So] Source:BMC Womens Health;17(1):54, 2017 Jul 27.
[Is] ISSN:1472-6874
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: To assess the attitude to and perception of transvaginal sonography (TVS) among Nigerian women of mixed educational status in order to ascertain factors that may prevent them from submitting to TVS when recommended. METHODS: A Cross-sectional survey was adopted for the study. In all, one missionary, one government and eight private hospitals were enlisted. The instruments for data collection were visual analogue scale (VAS), to ascertain patients' pain/discomfort experience, and a researcher-developed semi-structured questionnaire. The level of pain/discomfort on the VAS was categorized into four on a scale of 100. The categories were: 0-5 (no pain), 6-40 (mild pain), 41-74 (moderate pain), and 75-100 (severe pain). RESULTS: Majority (50.6%) of the respondents who attained secondary education had positive attitude to TVS. Also majority of the respondents (63.1%) preferred female sonographers. Majority of the respondents (54.1%) perceived TVS as not embarrassing, 78% did not consider it stressful, 96.9% reported that the sonographers were professional, 46.7% felt that a chaperon was needed, 98.4% reported there were enough privacy and 84.7% reported they needed prior information. Most of the respondents (82%) were willing to consent to TVS in future, 90.5% reported no pain, 8.6% reported mild pain/discomfort and 0.9% reported moderate pain. CONCLUSIONS: Majority of our respondents had positive attitude to TVS and were willing to consent to TVS in future, hence it was acceptable to them. It was however observed that acceptability increased with increasing academic status.
[Mh] Termos MeSH primário: Escolaridade
Genitália Feminina/diagnóstico por imagem
Aceitação pelo Paciente de Cuidados de Saúde/psicologia
Ultrassonografia/psicologia
Vagina/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos Transversais
Feminino
Seres Humanos
Meia-Idade
Dor/etiologia
Dor/psicologia
Medição da Dor/métodos
Percepção
Inquéritos e Questionários
Ultrassonografia/efeitos adversos
Ultrassonografia/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1186/s12905-017-0413-z


  9 / 7659 MEDLINE  
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[PMID]:28728138
[Au] Autor:Barrett ES; Sathyanarayana S; Mbowe O; Thurston SW; Redmon JB; Nguyen RHN; Swan SH
[Ad] Endereço:Department of Epidemiology, Environmental and Occupational Health Sciences Institute, Rutgers University School of Public Health, Piscataway, New Jersey, USA
[Ti] Título:First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.
[So] Source:Environ Health Perspect;125(7):077008, 2017 07 11.
[Is] ISSN:1552-9924
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans. METHODS: BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity-adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates. RESULTS: BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [ß=−0.56, 95% confidence interval (CI): −0.97, −0.15]. We observed no association between maternal BPA and infant AGD-AF. CONCLUSION: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. https://doi.org/10.1289/EHP875.
[Mh] Termos MeSH primário: Canal Anal/efeitos dos fármacos
Compostos Benzidrílicos/urina
Disruptores Endócrinos/urina
Genitália Feminina/efeitos dos fármacos
Fenóis/urina
[Mh] Termos MeSH secundário: Canal Anal/anatomia & histologia
Feminino
Genitália Feminina/anatomia & histologia
Seres Humanos
Recém-Nascido
Gravidez
Primeiro Trimestre da Gravidez/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Endocrine Disruptors); 0 (Phenols); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1289/EHP875


  10 / 7659 MEDLINE  
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[PMID]:28635231
[Au] Autor:Song Y; Huang X; Shen GH; Liu XY; Zhang X
[Ad] Endereço:Department of Pathology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
[Ti] Título:[Comparison of paired box genes 8 and 2 expression in epithelium tissues and the related tumors].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(6):424-428, 2017 Jun 23.
[Is] ISSN:0253-3766
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To explore the expressional differences between paired box genes 2(Pax2) and 8 (Pax8) protein in different kinds of epitheliums and tumors, and to investigate the clinicopathologic significance. Expression levels of Pax2 and Pax8 protein were detected in 75 cases of different human epithelium tissues and 255 cases of different tumors on tissue microarray by immunohistochemistry. Pax2 and Pax8 selectively expressed in different tissues. The positive rates of Pax8 protein expressed in the normal epithelium of the thyroid, urinary system and female reproductive system were 100% (2/2), 60.0% (3/5) and 76.9% (10/13), respectively. The positive rates of Pax2 expressed in the epithelium tissues of urinary system and the female reproductive system were 40.0% (2/5) and 38.5% (5/13) respectively. However, the expression of Pax2 protein was not detected in the normal thyroid epithelium. The positive rate of Pax8 protein expressing in the epithelium of reproductive system was significantly higher than that of Pax2 protein ( <0.05). The tumors derived from different tissues also expressed different levels of protein Pax2 and Pax8. The positive rates of Pax8 in renal cell carcinoma, thyroid carcinoma and endometrial adenocarcinoma were 65.2% (15/23), 66.7% (10/15) and 80.0% (4/5), respectively. The positive rates of Pax2 in renal cell carcinoma, thyroid carcinoma and endometrial adenocarcinoma were 34.8% (8/23), 13.3% (2/15) and 20.0% (1/5), respectively. The positive rates of Pax8 protein expressed in renal cell carcinoma, thyroid carcinoma and endometrial adenocarcinoma were significantly higher than those of Pax2 protein ( <0.05). The positive rates of Pax8 in ovarian serous carcinoma, endometrial carcinoma and clear cell carcinoma were 92.9% (26/28), 81.8% (9/11) and 82.4% (14/17), respectively. The positive rates of Pax2 in ovarian serous carcinoma, endometrial carcinoma and clear cell carcinoma were 28.6% (8/28), 9.1% (1/11) and 17.6% (3/17), respectively. The positive rates of Pax8 protein expressed in ovarian serous carcinoma, endometrial carcinoma and clear cell carcinomawere significantly higher than those of Pax2 protein ( <0.05). Pax2 and Pax8 are specifically expressed in female reproductive system and uritany system. However, the positive expression of Pax8 is superior to that of Pax2. The combined expression of Pax8 and Pax2 can be used in the differential diagnosis of epithelial tumors derived from different origins.
[Mh] Termos MeSH primário: Epitélio/metabolismo
Expressão Gênica
Proteínas de Neoplasias/genética
Fator de Transcrição PAX2/genética
Fator de Transcrição PAX8/genética
[Mh] Termos MeSH secundário: Adenocarcinoma de Células Claras/metabolismo
Carcinoma de Células Renais/metabolismo
Diagnóstico Diferencial
Feminino
Genitália Feminina/metabolismo
Seres Humanos
Imuno-Histoquímica
Masculino
Proteínas de Neoplasias/metabolismo
Neoplasias Epiteliais e Glandulares/metabolismo
Especificidade de Órgãos
Neoplasias Ovarianas/metabolismo
Fator de Transcrição PAX2/metabolismo
Fator de Transcrição PAX8/metabolismo
Glândula Tireoide/metabolismo
Análise Serial de Tecidos
Sistema Urinário/metabolismo
Neoplasias Uterinas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neoplasm Proteins); 0 (PAX2 Transcription Factor); 0 (PAX8 Transcription Factor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.06.005



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