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[PMID]:29505548
[Au] Autor:Xu M; Zhou F; Huang L
[Ad] Endereço:Department of Pathology.
[Ti] Título:Concomitant endometrial and cervical adenocarcinoma: A case report and literature review.
[So] Source:Medicine (Baltimore);97(1):e9596, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Concomitant malignancy of the endometrium and cervix is extremely rare. PATIENT CONCERNS: A 56-year-old female presented to the Women's Hospital, School of Medicine, Zhejiang University, complaining of irregular vaginal bleeding. The human papillomavirus test (type 18/45) was positive. We performed dilation and curettage; pathology revealed moderately differentiated endometrial carcinoma exhibiting squamous differentiation. The epithelium of the cervical uterus was atypical upon biopsy. DIAGNOSES: Histological and immunochemical tests confirmed a diagnosis of endometrial carcinoma concomitant with cervical adenocarcinoma. INTERVENTIONS: She underwent laparoscopic staging surgery. OUTCOMES: The patient fully recovered with only surgery. LESSONS: Endometrial carcinoma concomitant with cervical adenocarcinoma is very rare. It is imperative to schedule adequate examination, and to perform careful preoperative diagnosis and appropriate treatment to minimize relapse.
[Mh] Termos MeSH primário: Adenocarcinoma/patologia
Neoplasias do Endométrio/patologia
Neoplasias Primárias Múltiplas/patologia
Neoplasias do Colo do Útero/patologia
Útero/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180306
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009596


  2 / 47048 MEDLINE  
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[PMID]:29346447
[Au] Autor:Chang HJ; Shin HS; Kim TH; Yoo JY; Teasley HE; Zhao JJ; Ha UH; Jeong JW
[Ad] Endereço:Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI, United States of America.
[Ti] Título:Pik3ca is required for mouse uterine gland development and pregnancy.
[So] Source:PLoS One;13(1):e0191433, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The PI3K/AKT signaling pathway plays a critical role in the maintenance of equilibrium between cell survival and apoptosis. The Pik3ca gene is mutated in a range of human cancers. It has been found to be oncogenic, and mutations lead to constitutive activation of the PI3K/AKT pathway. The expression patterns of PIK3CA proteins in the uterus of mice during early pregnancy indicate that it may play a role in the regulation of glandular epithelial cells, which is required to support uterine receptivity. To further investigate the role of Pik3ca in uterine function, Pik3ca was conditionally ablated only in the PGR-positive cells (Pgrcre/+Pik3caf/f; Pik3cad/d). A defect of uterine gland development and decidualization led to subfertility observed in Pik3cad/d mice. Pik3cad/d mice showed significantly decreased uterine weight compared to Pik3caf/f mice. Interestingly, a significant decrease of gland numbers were detected in Pik3cad/d mice compared to control mice. In addition, we found a decrease of Foxa2 expression, which is a known uterine gland marker in Pik3cad/d mice. Furthermore, the excessive proliferation of endometrial epithelial cells was observed in Pik3cad/d mice. Our studies suggest that Pik3ca has a critical role in uterine gland development and female fertility.
[Mh] Termos MeSH primário: Fosfatidilinositol 3-Quinases/metabolismo
Útero/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Western Blotting
Proliferação Celular
Decídua/citologia
Decídua/crescimento & desenvolvimento
Implantação do Embrião
Feminino
Fertilidade
Camundongos
Camundongos Endogâmicos C57BL
Mutação
Fosfatidilinositol 3-Quinases/genética
Gravidez
Reação em Cadeia da Polimerase em Tempo Real
Útero/citologia
Útero/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.1.137 (Pik3ca protein, mouse)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191433


  3 / 47048 MEDLINE  
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[PMID]:28449642
[Au] Autor:Polat I; Yücel B; Gedikbasi A; Aslan H; Fendal A
[Ad] Endereço:Department of Obstetrics and Gynecology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey.
[Ti] Título:The effectiveness of double incision technique in uterus preserving surgery for placenta percreta.
[So] Source:BMC Pregnancy Childbirth;17(1):129, 2017 04 27.
[Is] ISSN:1471-2393
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Placenta percreta is a life-threatening condition that places patients at risk of massive bleeding. It necessitates very complicated surgery and can result in mortality. Caesarean hysterectomy is the accepted procedure worldwide; however, recent studies discussing conservative treatment with segmental resections have been published. Foetal extraction and segmental resection can be performed through the same incision (single uterine incision) or through two different incisions (double uterine incision). In this study, we aimed to evaluate the effectiveness and results of the double incision technique. METHODS: Twenty-two patients with a diagnosis of placenta percreta who underwent conservative surgery were included. Segmental resection was performed via single incision in ten patients and double incision in twelve patients. RESULTS: There was no difference between the patients who underwent segmental resection via single and double incision in terms of age, gravida, number of previous caesarean deliveries, gestational age at delivery, or rate of elective surgeries. The operation time, transfusion requirement, intensive care unit admission, total hospitalization and success of conservative surgery were comparable between the groups. CONCLUSIONS: Based on the outcomes of our study, double uterine incision allows for the safe extraction of the foetus during uterus-preserving surgery in patients with placenta percreta without worsening the results compared to single uterine incision. TRIAL REGISTRATION: NCT02702024 , Date of registration: February 26, 2016, retrospectively registered.
[Mh] Termos MeSH primário: Tratamentos com Preservação do Órgão/métodos
Placenta Acreta/cirurgia
Ferida Cirúrgica
Útero/cirurgia
[Mh] Termos MeSH secundário: Adulto
Feminino
Seres Humanos
Gravidez
Estudos Retrospectivos
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12884-017-1262-3


  4 / 47048 MEDLINE  
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[PMID]:29480840
[Au] Autor:De Nola R; Di Naro E; Schonauer LM; Lucarelli G; Battaglia M; Fiore MG; Mastrolia SA; Loverro G
[Ad] Endereço:Department of Biomedical Sciences and Human Oncology, Gynaecologic and Obstetrics Clinic.
[Ti] Título:Clinical management of a unique case of PNET of the uterus during pregnancy, and review of the literature.
[So] Source:Medicine (Baltimore);97(2):e9505, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: PNETs (primitive neuroectodermal tumors) are a family of highly malignant neoplasms characterized by small round cells of neuroepithelial origin. They usually involve bone and soft tissues, and have a higher incidence in childhood. PATIENT CONCERNS: In this case report, we describe the obstetric and oncological outcome of a huge mass diagnosed as a leiomyoma in a 39-year-old pregnant woman who complained of low back pain, dysuria, and urinary frequency at 22 weeks of gestation. DIAGNOSES: During the 25th week of pregnancy, the patient was referred to our hospital at night with severe anemia and suspected hemoperitoneum. She underwent an emergency caesarean section, delivering a female fetus weighing 400 g, with an Apgar score of 7 at 1 minute and 9 at 5 minutes. INTERVENTION: During surgery, we found a huge uterine sarcoma-like metastatic tumor, invading the pelvic peritoneum and parametria bilaterally; the adnexae seemed disease-free. We performed a type B radical hysterectomy, bilateral salpingo-oophorectomy, pelvic peritonectomy, omentectomy, appendectomy, and excision of a bulky lymph node. Seven days after delivery, staging computed tomography (CT) scan demonstrated a large lombo-aortic lymph node compressing the left renal vein and we completed debulking with a second surgery, including diaphragmatic peritonectomy and excision of a huge lymph node by lombo-aortic lymphadenectomy, requiring partial reconstruction of an infiltrated renal vein. OUTCOME: Ten days after the second surgery, echo-color Doppler showed a regular microcirculation in the left kidney. The patient was discharged after 10 days, and the baby after 1 month, both in good health.Histological examination revealed a uterine body cPNET (central primitive neuroectodermal tumor) orienting the clinical management toward chemotherapy with cisplatin and etoposide. LESSONS: PNETs are aggressive neoplasms, usually diagnosed at an advanced stage. Due to their low incidence, universally accepted guidelines are still unavailable. Radical surgery leaving no macroscopic residual disease is mandatory in advanced stages. A good fertility-sparing procedure can be performed only in young women at early stages of disease, when the wish for childbearing is not yet fulfilled.
[Mh] Termos MeSH primário: Tumores Neuroectodérmicos Primitivos/cirurgia
Complicações Neoplásicas na Gravidez/cirurgia
Neoplasias Uterinas/cirurgia
[Mh] Termos MeSH secundário: Adulto
Cesárea
Serviços Médicos de Emergência
Feminino
Seres Humanos
Recém-Nascido
Tumores Neuroectodérmicos Primitivos/diagnóstico por imagem
Tumores Neuroectodérmicos Primitivos/tratamento farmacológico
Tumores Neuroectodérmicos Primitivos/patologia
Gravidez
Complicações Neoplásicas na Gravidez/diagnóstico por imagem
Complicações Neoplásicas na Gravidez/tratamento farmacológico
Complicações Neoplásicas na Gravidez/patologia
Neoplasias Uterinas/diagnóstico por imagem
Neoplasias Uterinas/tratamento farmacológico
Neoplasias Uterinas/patologia
Útero/diagnóstico por imagem
Útero/patologia
Útero/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180227
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009505


  5 / 47048 MEDLINE  
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[PMID]:29424516
[Au] Autor:Hernández-Escobar CE; Carrillo-Martínez MA; Arroyo-Lemarroy T; ZamoraMorales MT; Garza-García GA; Campos-Sanmiguel E
[Ti] Título:[Uterine arteriovenous malformation as cause of uterine bleeding of sudden onset. Doppler ultrasound utility, other imaging methods and the minimally invasive treatment].
[Ti] Título:Malformación arteriovenosa uterina como causa de hemorragia uterina súbita. Utilidad del ultrasonido Doppler de consultorio, otros métodos de imagen y tratamiento de mínima invasion..
[So] Source:Ginecol Obstet Mex;84(8):535-41, 2016 08.
[Is] ISSN:0300-9041
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Ab] Resumo:Background: Uterine arteriovenous malformation is a rare disorder that can cause sudden life-threatening vaginal bleeding. Objetive: To present the clinical features in addition to the use of office gynecologic ultrasound and other imaging techniques in the diagnosis and minimally-invasive treatment of a patient with sudden vaginal bleeding resulting from a uterine arteriovenous malformation. Case report: A 31 year old woman presented sudden onset vaginal bleeding requiring the transfusion of 3 units of red blood cells. An initial diagnosis of uterine arteriovenous malformation was made using an office gynecological ultrasound and Color Doppler sonography. The patient was referred to interventional radiology for confirmation of the diagnosis and patient care. The diagnosis and localization of the uterine arteriovenous malformation was confirmed using magnetic resonance imaging. Therapeutic management proceeded with superselective angiography and embolization of the supplying arteries resulting in immediate symptomatic resolution. Conclusion: The use of office gynecologic ultrasound in combination with other imaging techniques is an important tool in the diagnosis and localization of uterine arteriovenous malformation. Embolization of supplying arteries is considered a safe and effective therapeutic option due to advances in radiologic intervention techniques. Advantages of this procedure include a minimally-invasive technique, low morbidity and preservation of uterine function.
[Mh] Termos MeSH primário: Malformações Arteriovenosas/complicações
Embolização da Artéria Uterina/métodos
Hemorragia Uterina/etiologia
Útero/irrigação sanguínea
[Mh] Termos MeSH secundário: Adulto
Malformações Arteriovenosas/diagnóstico por imagem
Malformações Arteriovenosas/terapia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Ultrassonografia Doppler em Cores
Hemorragia Uterina/terapia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180210
[St] Status:MEDLINE


  6 / 47048 MEDLINE  
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[PMID]:28450252
[Au] Autor:Exacoustos C; Pizzo A; Lazzeri L; Pietropolli A; Piccione E; Zupi E
[Ad] Endereço:Department of Biomedicine and Prevention, Obstetrics and Gynecological Clinic, University of Rome "Tor Vergata", Rome, Italy.
[Ti] Título:Three-Dimensional Hysterosalpingo Contrast Sonography with Gel Foam: Methodology and Feasibility to Obtain 3-Dimensional Volumes of Tubal Shape.
[So] Source:J Minim Invasive Gynecol;24(5):827-832, 2017 Jul - Aug.
[Is] ISSN:1553-4669
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To investigate the feasibility of hysterosalpingo foam sonography (HyFoSy) with automated 3-dimensional (3D) software in the evaluation of tubal patency and visualization of the tubal course by obtaining a 3D volume acquisition of tubes. DESIGN: Prospective observational study (Canadian Task Force classification III). SETTING: University hospital. PATIENTS: A total of 132 infertile females evaluated between October 2013 and February 2015. INTERVENTIONS: All patients underwent HyFoSy with the new automated 3D coded contrast imaging (CCI) followed by 2-dimensional (2D) real-time HyFoSy. To evaluate the feasibility of 3D visualization of the tubal course, consecutive volume acquisitions were performed during gel foam contrast agent injection. Conventional 2D real-time hysterosalpingo contrast sonography (HyCoSy) by detection of gel foam moving through the tubes and around the ovaries was finally performed and considered to indicate the final results of tubal status. MEASUREMENTS AND MAIN RESULTS: All the patients underwent 3D CCI HyFoSy, followed by 2D real-time HyFoSy. After both procedures, we observed 108 patients (81.8%) with bilateral tubal patency, 22 patients (16.6%) with unilateral tubal patency, and 2 patients (1.5%) with bilateral tubal occlusion. The concordance rate for tubal status between the first and second 3D volume acquisitions and the final 2D real-time evaluation was 84.8% and 97.0%, respectively. CONCLUSIONS: Transvaginal ultrasound HyFoSy with 3D volume reconstruction of the uterus and tubes is an accurate and safe technique that allows complete visualization of tubal shape and patency with high patient compliance.
[Mh] Termos MeSH primário: Endossonografia/métodos
Testes de Obstrução das Tubas Uterinas/métodos
Tubas Uterinas/diagnóstico por imagem
Histerossalpingografia/métodos
Imagem Tridimensional/métodos
[Mh] Termos MeSH secundário: Adulto
Meios de Contraste
Tubas Uterinas/patologia
Estudos de Viabilidade
Feminino
Seres Humanos
Infertilidade Feminina/diagnóstico
Infertilidade Feminina/diagnóstico por imagem
Tamanho do Órgão
Ovário/diagnóstico por imagem
Estudos Prospectivos
Software
Útero/diagnóstico por imagem
Cremes, Espumas e Géis Vaginais
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Contrast Media); 0 (Vaginal Creams, Foams, and Jellies)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:29381706
[Au] Autor:Mohr EL; Block LN; Newman CM; Stewart LM; Koenig M; Semler M; Breitbach ME; Teixeira LBC; Zeng X; Weiler AM; Barry GL; Thoong TH; Wiepz GJ; Dudley DM; Simmons HA; Mejia A; Morgan TK; Salamat MS; Kohn S; Antony KM; Aliota MT; Mohns MS; Hayes JM; Schultz-Darken N; Schotzko ML; Peterson E; Capuano S; Osorio JE; O'Connor SL; Friedrich TC; O'Connor DH; Golos TG
[Ad] Endereço:Department of Pediatrics, University of Wisconsin-Madison, Madison, Wisconsin, United States of America.
[Ti] Título:Ocular and uteroplacental pathology in a macaque pregnancy with congenital Zika virus infection.
[So] Source:PLoS One;13(1):e0190617, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Congenital Zika virus (ZIKV) infection impacts fetal development and pregnancy outcomes. We infected a pregnant rhesus macaque with a Puerto Rican ZIKV isolate in the first trimester. The pregnancy was complicated by preterm premature rupture of membranes (PPROM), intraamniotic bacterial infection and fetal demise 49 days post infection (gestational day 95). Significant pathology at the maternal-fetal interface included acute chorioamnionitis, placental infarcts, and leukocytoclastic vasculitis of the myometrial radial arteries. ZIKV RNA was disseminated throughout fetal tissues and maternal immune system tissues at necropsy, as assessed by quantitative RT-PCR for viral RNA. Replicating ZIKV was identified in fetal tissues, maternal uterus, and maternal spleen by fluorescent in situ hybridization for viral replication intermediates. Fetal ocular pathology included a choroidal coloboma, suspected anterior segment dysgenesis, and a dysplastic retina. This is the first report of ocular pathology and prolonged viral replication in both maternal and fetal tissues following congenital ZIKV infection in a rhesus macaque. PPROM followed by fetal demise and severe pathology of the visual system have not been described in macaque congenital ZIKV infection previously. While this case of ZIKV infection during pregnancy was complicated by bacterial infection with PPROM, the role of ZIKV on this outcome cannot be precisely defined, and further nonhuman primate studies will determine if increased risk for PPROM or other adverse pregnancy outcomes are associated with congenital ZIKV infection.
[Mh] Termos MeSH primário: Modelos Animais de Doenças
Olho/patologia
Placenta/patologia
Útero/patologia
Infecção pelo Zika virus/congênito
[Mh] Termos MeSH secundário: Animais
Feminino
Hibridização in Situ Fluorescente
Macaca mulatta
Gravidez
RNA Viral/genética
Replicação Viral
Zika virus/genética
Zika virus/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (RNA, Viral)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180223
[Lr] Data última revisão:
180223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190617


  8 / 47048 MEDLINE  
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[PMID]:29289536
[Au] Autor:Teasley HE; Chang HJ; Kim TH; Ku BJ; Jeong JW
[Ad] Endereço:Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, College of Human Medicine, Grand Rapids, MI 49503, USA; Department of Biology, Kalamazoo College, Kalamazoo, MI, USA.
[Ti] Título:Expression of PIK3IP1 in the murine uterus during early pregnancy.
[So] Source:Biochem Biophys Res Commun;495(4):2553-2558, 2018 01 22.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The ovarian steroid hormones, estrogen (E2) and progesterone (P4), are essential regulators of uterine functions necessary for development, embryo implantation, and normal pregnancy. ARID1A plays an important role in steroid hormone signaling in endometrial function and pregnancy. In previous studies, using high density DNA microarray analysis, we identified phosphatidylinositol-3-kinase interacting protein 1 (Pik3ip1) as one of the genes up-regulated by ARID1A. In the present study, we performed real-time qPCR and immunohistochemistry analysis to investigate the regulation of PIK3IP1 by ARID1A and determine expression patterns of PIK3IP1 in the uterus during early pregnancy. The expression of PIK3IP1 was strong at the uterine epithelial and stromal cells of the control mice. However, expression of PIK3IP1 was remarkably reduced in the Pgr Arid1a mice and progesterone receptor knock-out (PRKO) mice. During early pregnancy, PIK3IP1 expression was strong at day 2.5 of gestation (GD 2.5) and then slightly decreased at GD 3.5 at the epithelium and stroma. After implantation, PIK3IP1 expression was detected at the secondary decidualization zone. To determine the ovarian steroid hormone regulation of PIK3IP1, we examined the expression of PIK3IP1 in ovariectomized control, Pgr Arid1a , and PRKO mice treated with P4 or E2. P4 treatment increased the PIK3IP1 expression at the luminal and glandular epithelium of control mice. However, the PIK3IP1 induction was decreased in both the Pgr Arid1a and PRKO mice, compared to controls. Our results identified PIK3IP1 as a novel target of ARID1A and PGR in the murine uterus.
[Mh] Termos MeSH primário: Proteínas de Transporte/metabolismo
Proteínas de Ligação a DNA/metabolismo
Desenvolvimento Embrionário/fisiologia
Proteínas Nucleares/metabolismo
Prenhez/metabolismo
Receptores de Progesterona/metabolismo
Útero/metabolismo
[Mh] Termos MeSH secundário: Animais
Feminino
Regulação da Expressão Gênica no Desenvolvimento/fisiologia
Camundongos
Gravidez
Distribuição Tecidual
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
0 (Arid1a protein, mouse); 0 (Carrier Proteins); 0 (DNA-Binding Proteins); 0 (Nuclear Proteins); 0 (Pik3ip1 protein, mouse); 0 (Receptors, Progesterone)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180101
[St] Status:MEDLINE


  9 / 47048 MEDLINE  
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[PMID]:29297614
[Au] Autor:Ludwin A
[Ad] Endereço:Department of Gynecology and Oncology, Jagiellonian University, Krakow, Poland.
[Ti] Título:Re: Outcome of assisted reproduction in women with congenital uterine anomalies: a prospective observational study. M. Prior, A. Richardson, S. Asif, L. Polanski, M. Parris-Larkin, J. Chandler, L. Fogg, P. Jassal, J. G. Thornton, N. J. Raine-Fenning. Ultrasound Obstet Gynecol 2018; 51: 110-117.
[So] Source:Ultrasound Obstet Gynecol;51(1):22-23, 2018 01.
[Is] ISSN:1469-0705
[Cp] País de publicação:England
[La] Idioma:eng
[Mh] Termos MeSH primário: Anormalidades Urogenitais
Útero
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Estudos Prospectivos
Útero/anormalidades
[Pt] Tipo de publicação:JOURNAL ARTICLE; COMMENT
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180123
[Lr] Data última revisão:
180123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180104
[St] Status:MEDLINE
[do] DOI:10.1002/uog.18971


  10 / 47048 MEDLINE  
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[PMID]:28466234
[Au] Autor:Negrón-Pérez VM; Hansen PJ
[Ad] Endereço:Department of Animal Sciences, D. H. Barron Reproductive and Perinatal Biology Research Program and Genetics Institute, University of Florida, Gainesville, Florida, USA.
[Ti] Título:The bovine embryo hatches from the zona pellucida through either the embryonic or abembryonic pole.
[So] Source:J Assist Reprod Genet;34(6):725-731, 2017 Jun.
[Is] ISSN:1573-7330
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Implantation of the mammalian embryo in the uterus is preceded by escape from the zona pellucida. In some species, hatching from the zona occurs preferentially from one or the other poles of the embryo. The situation for the bovine embryo, in which hatching precedes attachment to the uterus by more than a week, is unclear. The purpose was to describe whether hatching of the bovine embryo from the zona pellucida occurs preferentially from the embryonic or abembryonic pole. METHODS: Bovine blastocysts undergoing hatching were examined by light microscopy (n = 84) and epifluorescence imaging using antibodies for markers of epiblast, hypoblast, and trophectoderm (TE) (n = 26). The location of hatching was classified as being at the embryonic pole, if hatching occurred ipsilateral to the inner cell mass (ICM), or abembryonic, if hatching occurred contralateral to the ICM. RESULTS: A total of 55% of blastocysts exited the zona pellucida through an opening at the embryonic pole. In these cases, 68% of the cells emerging through the zona pellucida were derived from the ICM. The remainder of blastocysts hatched from an opening either contralateral or to the side of the ICM. In these cases, 87% of hatched cells were TE. CONCLUSION: For the bovine embryo, there is nearly equal probability of hatching from the embryonic or abembryonic poles. Given that the surface area of the zona pellucida in contact with the TE overlying the ICM is less than for the remainder of the blastocyst, there is some preference for hatching through the embryonic pole. Thus, the bovine embryo is distinct from the mouse and human, where hatching occurs preferentially at the abembryonic pole.
[Mh] Termos MeSH primário: Implantação do Embrião/fisiologia
Desenvolvimento Embrionário/fisiologia
Útero/crescimento & desenvolvimento
Zona Pelúcida/fisiologia
[Mh] Termos MeSH secundário: Animais
Blastocisto/fisiologia
Bovinos
Contagem de Células
Implantação do Embrião/genética
Embrião de Mamíferos/fisiologia
Desenvolvimento Embrionário/genética
Feminino
Seres Humanos
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1007/s10815-017-0933-3



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