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[PMID]:29340522
[Au] Autor:Verri V; Brandão AA; Tibirica E
[Ad] Endereço:Instituto Nacional de Cardiologia, Ministério da Saúde, Rio de Janeiro, Brasil.
[Ti] Título:Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition.
[So] Source:Braz J Med Biol Res;51(3):e6601, 2018 Jan 11.
[Is] ISSN:1414-431X
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The primary aim of this study was to evaluate penile endothelial microvascular function in patients with primary arterial hypertension and age-matched normotensive subjects using laser speckle contrast imaging (LSCI). Additionally, we analyzed the acute penile microvascular effects induced by oral phosphodiesterase type 5 inhibitor (sildenafil; SIL) administration. Endothelium-dependent microvascular reactivity was evaluated in the penises and forearms of hypertensive patients (aged 58.8±6.6 years, n=34) and age-matched healthy volunteers (n=33) at rest and 60 min following oral SIL (100 mg) administration. LSCI was coupled with cutaneous acetylcholine (ACh) iontophoresis using increasing anodal currents. Basal penile cutaneous vascular conductance (CVC) values were not significantly different between control subjects and hypertensive individuals. Penile CVC values increased significantly after SIL administration in control (P<0.0001) and hypertensive (P<0.0001) subjects. Peak CVC values were not different between the two groups during penile ACh iontophoresis before SIL administration (P=0.2052). Peak CVC values were higher in control subjects than in hypertensive subjects after SIL administration (P=0.0427). Penile endothelium-dependent microvascular function is, to some extent, preserved in patients presenting with primary arterial hypertension under effective anti-hypertensive treatment. LSCI may be a valuable non-invasive tool for the evaluation of penile vascular responses to phosphodiesterase type 5 inhibitor.
[Mh] Termos MeSH primário: Endotélio Vascular/fisiopatologia
Hipertensão/fisiopatologia
Pênis/irrigação sanguínea
Inibidores da Fosfodiesterase 5/administração & dosagem
Citrato de Sildenafila/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Voluntários Saudáveis
Seres Humanos
Fluxometria por Laser-Doppler/métodos
Masculino
Microcirculação
Meia-Idade
Pênis/efeitos dos fármacos
Fluxo Sanguíneo Regional
Vasodilatação/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phosphodiesterase 5 Inhibitors); BW9B0ZE037 (Sildenafil Citrate)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180118
[St] Status:MEDLINE


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[PMID]:29406065
[Au] Autor:Manjunath AS; Hofer MD
[Ad] Endereço:Department of Urology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue 16-703, Chicago, IL 60611, USA.
[Ti] Título:Urologic Emergencies.
[So] Source:Med Clin North Am;102(2):373-385, 2018 Mar.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Urologic emergencies can involve the kidneys, ureters, bladder, urethra, penis, scrotum, or testicles. History and physical examination are essential to diagnosis, whereas imaging is increasingly used to confirm diagnoses. Acute urinary retention should be relieved with Foley placement. Penile emergencies include paraphimosis, which can be treated by foreskin reduction, whereas penile fracture and priapism require urologic intervention. Fournier gangrene and testicular torsion are scrotal emergencies requiring emergent surgery. Nephrolithiasis, although painful, is not an emergency unless there is concern for concomitant urinary tract infection, both ureters are obstructed by stones, or there is an obstructing stone in a solitary kidney.
[Mh] Termos MeSH primário: Doenças Urológicas/diagnóstico
Doenças Urológicas/terapia
[Mh] Termos MeSH secundário: Doença Aguda
Emergências
Feminino
Doenças Urogenitais Femininas/diagnóstico
Doenças Urogenitais Femininas/terapia
Gangrena de Fournier/diagnóstico
Gangrena de Fournier/terapia
Seres Humanos
Masculino
Doenças Urogenitais Masculinas/diagnóstico
Doenças Urogenitais Masculinas/terapia
Nefrolitíase/diagnóstico
Nefrolitíase/microbiologia
Nefrolitíase/terapia
Parafimose/diagnóstico
Parafimose/terapia
Pênis/lesões
Priapismo/diagnóstico
Priapismo/terapia
Encaminhamento e Consulta
Ruptura
Torção do Cordão Espermático/diagnóstico
Torção do Cordão Espermático/terapia
Retenção Urinária/diagnóstico
Retenção Urinária/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29406061
[Au] Autor:Kiechle JE; Chertack N; Gonzalez CM
[Ad] Endereço:Urology Institute, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44106, USA.
[Ti] Título:Penile and Urethral Reconstructive Surgery.
[So] Source:Med Clin North Am;102(2):325-335, 2018 Mar.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Penile and urethral reconstructive surgical procedures are used to treat a variety of urologic diagnoses. Urethral stricture disease can lead to progressive lower urinary tract symptoms and may require multiple surgical procedures to improve patient's symptoms. Male stress urinary incontinence is associated with intrinsic sphincter deficiency oftentimes associated with radical prostatectomy. Men suffering from urethral stricture disease and stress urinary incontinence should be referred to a urologist because multiple treatment options exist to improve their quality of life.
[Mh] Termos MeSH primário: Pênis/cirurgia
Procedimentos Cirúrgicos Reconstrutivos/métodos
Uretra/cirurgia
Doenças Uretrais/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Masculino
Encaminhamento e Consulta
Estreitamento Uretral/cirurgia
Incontinência Urinária por Estresse
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29406058
[Au] Autor:Yura E; Flury S
[Ad] Endereço:Department of Urology, Northwestern University, Tarry Building Room 16-703, 300 East Superior Street, Chicago, IL 60611, USA.
[Ti] Título:Cutaneous Lesions of the External Genitalia.
[So] Source:Med Clin North Am;102(2):279-300, 2018 Mar.
[Is] ISSN:1557-9859
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Individuals with cutaneous diseases of the external genitalia often initially present to their primary care provider. When present, these conditions may be associated with considerable physical symptoms and psychological distress. Dermatoses affecting the genitals may be of infectious, inflammatory, or neoplastic cause, and can be processes confined to the genitalia or a manifestation of a more widespread dermatologic condition. This article provides a guide to recognizing and managing common genital dermatoses and when to refer for specialist opinion.
[Mh] Termos MeSH primário: Doenças dos Genitais Femininos/diagnóstico
Doenças dos Genitais Masculinos/diagnóstico
Genitália/patologia
Dermatopatias/diagnóstico
[Mh] Termos MeSH secundário: Feminino
Doenças dos Genitais Femininos/etiologia
Doenças dos Genitais Masculinos/etiologia
Seres Humanos
Masculino
Pênis/patologia
Escroto/patologia
Dermatopatias/etiologia
Vulva/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29293559
[Au] Autor:Plummer EL; Vodstrcil LA; Danielewski JA; Murray GL; Fairley CK; Garland SM; Hocking JS; Tabrizi SN; Bradshaw CS
[Ad] Endereço:Department of Molecular Microbiology, Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
[Ti] Título:Combined oral and topical antimicrobial therapy for male partners of women with bacterial vaginosis: Acceptability, tolerability and impact on the genital microbiota of couples - A pilot study.
[So] Source:PLoS One;13(1):e0190199, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Recurrence following recommended treatment for bacterial vaginosis is unacceptably high. While the pathogenesis of recurrence is not well understood, recent evidence indicates re-infection from sexual partners is likely to play a role. The aim of this study was to assess the acceptability and tolerability of topical and oral antimicrobial therapy in male partners of women with bacterial vaginosis (BV), and to investigate the impact of dual-partner treatment on the vaginal and penile microbiota. METHODS: Women with symptomatic BV (Nugent Score of 4-10 and ≥3 Amsel criteria) and their regular male sexual partner were recruited from Melbourne Sexual Health Centre, Melbourne, Australia. Women received oral metronidazole 400mg twice daily (or intra-vaginal 2% clindamycin cream, if contraindicated) for 7-days. Male partners received oral metronidazole 400mg twice daily and 2% clindamycin cream topically to the penile skin twice daily for 7-days. Couples provided self-collected genital specimens and completed questionnaires at enrolment and then weekly for 4-weeks. Genital microbiota composition was determined by 16S rRNA gene sequencing. Changes in genital microbiota composition were assessed by Bray-Curtis index. Bacterial diversity was measured by the Shannon Diversity Index. RESULTS: Twenty-two couples were recruited. Sixteen couples (76%) completed all study procedures. Adherence was high; most participants took >90% of prescribed medication. Medication, and particularly topical clindamycin in males, was well tolerated. Dual-partner treatment had an immediate and sustained effect on the composition of vaginal microbiota (median Bray-Curtis score day 0 versus day 8 = 0.03 [IQR 0-0.15], day 0 vs day 28 = 0.03 [0.02-0.11]). We observed a reduction in bacterial diversity of the vaginal microbiota and a decrease in the prevalence and abundance of BV-associated bacteria following treatment. Treatment had an immediate effect on the composition of the cutaneous penile microbiota (median Bray-Curtis score day 0 vs day 8 = 0.09 [0.04-0.17]), however this was not as pronounced at day 28 (median Bray-Curtis score day 0 vs day 28 = 0.38 [0.11-0.59]). A decrease in the prevalence and abundance of BV-associated bacteria in the cutaneous penile microbiota was observed immediately following treatment at day 8. CONCLUSION: Combined oral and topical treatment of male partners of women with BV is acceptable and well tolerated. The combined acceptability and microbiological data presented in this paper supports the need for larger studies with longer follow up to characterize the sustained effect of dual partner treatment on the genital microbiota of couples and assess the impact on BV recurrence.
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Pênis/microbiologia
Parceiros Sexuais
Vagina/microbiologia
Vaginose Bacteriana/tratamento farmacológico
[Mh] Termos MeSH secundário: Administração Oral
Administração Tópica
Adulto
Antibacterianos/administração & dosagem
Antibacterianos/efeitos adversos
Feminino
Seres Humanos
Masculino
Microbiota
Projetos Piloto
Pele/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180206
[Lr] Data última revisão:
180206
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190199


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[PMID]:29191197
[Au] Autor:Tang X; Olatunji OJ; Zhou Y; Hou X
[Ad] Endereço:College of Horticulture, Nanjing Agricultural University, Weigang No.1, Nanjing, Jiangsu, 210095, China.
[Ti] Título:In vitro and in vivo aphrodisiac properties of the seed extract from Allium tuberosum on corpus cavernosum smooth muscle relaxation and sexual behavior parameters in male Wistar rats.
[So] Source:BMC Complement Altern Med;17(1):510, 2017 Dec 01.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Allium tuberosum is a well-known spice as well as a herb in traditional Chinese medicine, used for increasing libido and treating erectile dysfunction. However, not many studies have been done to evaluate the sexual enhancing properties of A. tuberosum. The aim of this study was to evaluate the aphrodisiac and vasorelaxant properties of A. tuberosum on corpus cavernosum smooth muscle (CCSM) as well as checking the effect on enhancing male rat sexual behavior, libido, potency as well as its spermatogenic properties. METHOD: The seeds were powdered and sequentially extracted with hexane, ethyl acetate and butanol. Male Wistar rats were administered with graded doses of the n-BuOH extracts (ATB) of A. tuberosum (50, 100, 200 and 400 mg/kg) and Viagra was used as the positive control drug. The extract/drug was administered by gastric probe once daily for 45 days and the sexual behavior was analyzed by exposing the male rats to female rats in the estrus period. RESULTS: ATB relaxed corpus cavernosum smooth muscle (68.9%) at a concentration of 200 µg/ml. The results obtained from the animal studies indicated that ATB significantly increased mount frequency (MF), intromission frequency (IF), ejaculation frequency (EF), ejaculation latency (EL) and markedly reduced post ejaculatory interval (PEI), mount latency (ML), and intromission latency (IL). Furthermore, a remarkable increase in the test for potency was observed as witnessed by marked increase in erections, quick flips, long flips and total reflex. In addition, ATB significantly improved the sperm viability and count as well as increased the concentrations of testosterone, follicle stimulating hormone (FSH), and phosphatases in the treated animals. CONCLUSION: Thus our results suggest that A. tuberosum could stimulate sexual arousal and enhance sexual execution in male rats, thus providing valuable experimental evidence that A. tuberosum possesses sexual enhancing properties.
[Mh] Termos MeSH primário: Afrodisíacos/farmacologia
Cebolinha-Francesa/química
Relaxamento Muscular/efeitos dos fármacos
Extratos Vegetais/farmacologia
Comportamento Sexual/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Afrodisíacos/química
Feminino
Masculino
Músculo Liso/efeitos dos fármacos
Pênis/efeitos dos fármacos
Extratos Vegetais/química
Ratos
Ratos Wistar
Sementes/química
Citrato de Sildenafila/farmacologia
Espermatozoides/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Extracts); BW9B0ZE037 (Sildenafil Citrate)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171220
[Lr] Data última revisão:
171220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171202
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-2008-5


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[PMID]:27770854
[Au] Autor:Das ND; Yin GN; Choi MJ; Song KM; Park JM; Limanjaya A; Ghatak K; Minh NN; Ock J; Park SH; Kim HM; Ryu JK; Suh JK
[Ad] Endereço:National Research Center for Sexual Medicine and Department of Urology, Inha University School of Medicine, Incheon, Republic of Korea; Epigenetics Drug Discovery Unit, Division of Structural and Synthetic Biology, RIKEN Center for Life Science Technologies, Suehiro-cho, Yokohama, Japan.
[Ti] Título:Effectiveness of Intracavernous Delivery of Recombinant Human Hepatocyte Growth Factor on Erectile Function in the Streptozotocin-Induced Diabetic Mouse.
[So] Source:J Sex Med;13(11):1618-1628, 2016 11.
[Is] ISSN:1743-6109
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Diabetic erectile dysfunction is a disease mostly of vascular origin and men with diabetic erectile dysfunction respond poorly to oral phosphodiesterase-5 inhibitors. Hepatocyte growth factor (HGF) is a pleiotropic factor that plays an essential role in the regulation of cell proliferation, survival, and angiogenesis. AIM: To determine the effectiveness of recombinant human (rh)-HGF in restoring erectile function in diabetic mice. METHODS: Four groups of mice were used: control non-diabetic mice and streptozotocin-induced diabetic mice receiving two successive intracavernous injections of phosphate buffered saline (days -3 and 0), a single intracavernous injection of rh-HGF (day 0), or two successive intracavernous injections of rh-HGF (days -3 and 0). We also examined the effect of rh-HGF in primary cultured mouse cavernous endothelial cells and in major pelvic ganglion culture in vitro, which was incubated under a normal-glucose (5 mmol/L) or a high-glucose (30 mmol/L) condition. MAIN OUTCOME MEASURES: Two weeks after treatment, we measured erectile function by electrical stimulation of the cavernous nerve and the penis was harvested for histologic studies. RESULTS: Repeated intracavernous injections of rh-HGF protein induced significant restoration of erectile function in diabetic mice (89-100% of control values), whereas a single intracavernous injection of rh-HGF protein elicited modest improvement. Rh-HGF significantly induced phosphorylation of its receptor c-Met, increased the content of endothelial cells and smooth muscle cells, and decreased the generation of reactive oxygen species (superoxide anion and peroxynitrite) and extravasation of oxidized low-density lipoprotein in diabetic mice. Under the high-glucose condition, rh-HGF protein also promoted tube formation in mouse cavernous endothelial cells and enhanced neurite sprouting in major pelvic ganglion culture in vitro. CONCLUSION: The dual angiogenic and neurotrophic effects of HGF could open a new avenue through which diabetic erectile dysfunction can be treated.
[Mh] Termos MeSH primário: Disfunção Erétil/tratamento farmacológico
Fator de Crescimento de Hepatócito/farmacologia
Ereção Peniana/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/fisiologia
Diabetes Mellitus Experimental/fisiopatologia
Células Endoteliais/citologia
Células Endoteliais/fisiologia
Endotélio/metabolismo
Disfunção Erétil/fisiopatologia
Seres Humanos
Injeções Intralesionais
Lipoproteínas LDL/metabolismo
Masculino
Camundongos Endogâmicos C57BL
Óxido Nítrico Sintase Tipo III/metabolismo
Pênis/irrigação sanguínea
Inibidores da Fosfodiesterase 5/farmacologia
Fosforilação/fisiologia
Ratos Sprague-Dawley
Proteínas Recombinantes/farmacologia
Regeneração/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipoproteins, LDL); 0 (Phosphodiesterase 5 Inhibitors); 0 (Recombinant Proteins); 0 (oxidized low density lipoprotein); 67256-21-7 (Hepatocyte Growth Factor); EC 1.14.13.39 (Nitric Oxide Synthase Type III)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:27770853
[Au] Autor:Trost LW; Munarriz R; Wang R; Morey A; Levine L
[Ad] Endereço:Department of Urology, Mayo Clinic, Rochester, MN, USA. Electronic address: Trost.Landon@mayo.edu.
[Ti] Título:External Mechanical Devices and Vascular Surgery for Erectile Dysfunction.
[So] Source:J Sex Med;13(11):1579-1617, 2016 11.
[Is] ISSN:1743-6109
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The field of sexual medicine is continuously advancing, with novel outcomes reported on a regular basis. Given the rapid evolution, updated guidelines are essential to inform practicing clinicians on best practices. AIM: To summarize the current literature and provide clinical guidelines on penile traction therapy, vacuum erection devices, and penile revascularization. METHODS: A consensus panel was held with leading sexual medicine experts during the 2015 International Consultation on Sexual Medicine (ICSM). Relevant literature was reviewed and graded based on Oxford criteria to develop evidence-based guideline and consensus statements. MAIN OUTCOME MEASURES: The development of clinically relevant guidelines. RESULTS: Penile traction therapy is a viable therapy to modestly improve penile length as a primary therapy, before penile prosthesis placement in men with decreased penile length or after surgery for Peyronie's disease. It also might have a role in the acute phase of Peyronie's disease but has inconsistent outcomes in the long-term phase. Vacuum erection devices are effective in creating an erection satisfactory for intercourse, even in difficult-to-treat populations. They also might be used in the post-prostatectomy setting to maintain penile length but have insufficient evidence as a penile rehabilitation therapy. For vasculogenic erectile dysfunction, men with suspected arterial insufficiency can be evaluated with penile Duplex Doppler ultrasonography and confirmatory angiography. Penile revascularization procedures have consistently demonstrated benefits in very select patient populations; however, inadequate data exists to suggest the superiority of one technique. Men with vascular risk factors are likely poor candidates for penile revascularization, although veno-occlusive dysfunction and age are less significant. Therapies for treating primary veno-occlusive dysfunction are not recommended and should be reserved for clinical trials. CONCLUSIONS: Since the prior ICSM meeting, multiple developments have occurred in external mechanical devices and penile revascularization for the treatment of erectile and sexual dysfunction. Sexual medicine clinicians are encouraged to review and incorporate recommendations as applicable to their scope of practice.
[Mh] Termos MeSH primário: Disfunção Erétil/terapia
Induração Peniana/cirurgia
Procedimentos Cirúrgicos Vasculares/métodos
[Mh] Termos MeSH secundário: Consenso
Disfunção Erétil/etiologia
Disfunção Erétil/fisiopatologia
Seres Humanos
Masculino
Microcirurgia/métodos
Ereção Peniana/fisiologia
Implante Peniano/instrumentação
Implante Peniano/métodos
Prótese de Pênis
Pênis/irrigação sanguínea
Pênis/cirurgia
Prostatectomia/efeitos adversos
Encaminhamento e Consulta
Reperfusão/métodos
Fatores de Risco
Comportamento Sexual
Vácuo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171207
[Lr] Data última revisão:
171207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


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[PMID]:29016638
[Au] Autor:Westercamp N; Mehta SD; Jaoko W; Okeyo TA; Bailey RC
[Ad] Endereço:Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America.
[Ti] Título:Penile coital injuries in men decline after circumcision: Results from a prospective study of recently circumcised and uncircumcised men in western Kenya.
[So] Source:PLoS One;12(10):e0185917, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Penile coital injuries are one of the suggested mechanisms behind the increased risk of HIV among uncircumcised men. We evaluated the prevalence and correlates of self-reported penile coital injuries in a longitudinal community-based cohort of young (18-24 years old), newly circumcised and uncircumcised men in Western Kenya. METHODS: Self-reported penile coital injuries were assessed at baseline, 6, 12, 18 and 24 months of follow-up, and were defined as scratches, cuts or abrasions during sex, penile soreness during sex, and skin of the penis bleeding during sex. Associations between penile coital injuries, circumcision, sexual satisfaction, and other covariates were estimated with mixed effect models. RESULTS: Between November 2008 and April 2010 3,186 participants were enrolled (1,588 into circumcision group and 1,598 as age-matched controls). Among 2,106 (66%) participants sexually active at baseline, 53% reported any penile injury, including 44% scratches, cuts or abrasions; 32% penile pain/soreness; and 22% penile bleeding. In multivariable modeling, risk was lower for circumcised men than uncircumcised men for scratches, cuts and abrasions (aOR = 0.39; 95% CI 0.34-0.44); penile pain/soreness (aOR = 0.58; 95% CI 0.51-0.65), penile bleeding (aOR = 0.53; 95% CI 0.46-0.62), and any penile coital injuries (aOR = 0.47; 95%CI 0.42-0.53). Other significant risk factors included increasing age, history of STIs and genital sores, and multiple sex partners, while condom use was protective. Coital injuries were significantly associated with lower levels of sexual satisfaction in longitudinal analyses (scratches, cuts or abrasions: aOR = 0.87, 95% CI: 0.76-0.98; penile pain/soreness: aOR = 0.82, 95% CI: 0.72-0.93; and penile bleeding: aOR = 0.65, 95% CI: 0.55-0.76). CONCLUSIONS: Self-reported penile coital injuries were common and decreased significantly following circumcision. Improving sexual experience through the removal of a potential source of sexual discomfort may resonate with many men targeted for circumcision services. The role of penile coital injuries in sexual satisfaction, HIV, HSV-2, and as a motivator for seeking circumcision services should be explored further.
[Mh] Termos MeSH primário: Hemorragia/fisiopatologia
Orgasmo/fisiologia
Dor/fisiopatologia
Pênis/lesões
[Mh] Termos MeSH secundário: Adolescente
Estudos de Casos e Controles
Circuncisão Masculina/educação
Coito/fisiologia
Preservativos/utilização
Feminino
Seres Humanos
Quênia
Masculino
Pênis/fisiologia
Fatores Sexuais
Pele/lesões
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171031
[Lr] Data última revisão:
171031
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171011
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0185917


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[PMID]:28982169
[Au] Autor:Li H; Chen L; Wang T; Wang S; Liu J
[Ad] Endereço:Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
[Ti] Título:The effect of cavernous nerve traction on erectile function in rats.
[So] Source:PLoS One;12(10):e0186077, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We performed this study to evaluate the effect of cavernous nerve (CN) traction on erectile function in rats. Thirty-two 8- week-old Sprague-Dawley rats were divided into four groups: control, 1-minute CN traction, 2-minute CN traction, and 2-minute CN crush. CN traction was performed using a glass hook with a tensile force of 0.2 Newton. One month later, the mean arterial pressure (MAP) and intracavernosal pressure (ICP) in response to CN stimulation were measured to assess erectile function. The penis and major pelvic ganglion (MPG) were harvested to explore the expression of neuronal nitric oxide synthase (nNOS) and neurofilament, fibrosis and apoptosis. The ICP/MAP ratio was reduced in the 2-minute CN traction group compared with the control group (P < 0.05). The ICP/MAP ratio in the CN crush group was lower than in the other three groups (P < 0.05, for each). Expression of nNOS in both MPG and dorsal penile nerve was lower in the CN traction group than in the control group, but was higher than in the CN crush group (P < 0.05). Nerve fiber number in the dorsal penile nerve was reduced by 2-minute CN traction (P < 0.05). The ratios of collagen to smooth muscle content and the apoptosis were both increased the in 2-minute CN traction group compared with the control group (P < 0.05). The findings indicate that CN traction is an effective CN injury model and the injury it caused is relatively mild compared with the CN crush model.
[Mh] Termos MeSH primário: Ereção Peniana
Pênis/inervação
[Mh] Termos MeSH secundário: Animais
Apoptose
Western Blotting
Masculino
Óxido Nítrico Sintase Tipo I/metabolismo
Pênis/enzimologia
Pênis/patologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.13.39 (Nitric Oxide Synthase Type I)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0186077



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