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Pesquisa : A05.360.490.690.700 [Categoria DeCS]
Referências encontradas : 206 [refinar]
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[PMID]:29331483
[Au] Autor:Liu X; Li Z; Wang B; Zhu H; Liu Y; Qi J; Zhang Q
[Ad] Endereço:Key Laboratory of Marine Genetics and Breeding (Ocean University of China), Ministry of Education, 266003 Qingdao, Shandong, China.
[Ti] Título:GATA4 is a transcriptional regulator of R-spondin1 in Japanese flounder (Paralichthys olivaceus).
[So] Source:Gene;648:68-75, 2018 Mar 30.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:GATA4 is a well-known transcription factor of the GATA family implicated in regulation of sex determination and gonadal development in mammals. In this study, we cloned the full-length cDNA of Paralichthys olivaceus gata4 (Po-gata4). Phylogenetic, gene structure, and synteny analysis showed that Po-GATA4 is homologous to GATA4 of teleost and tetrapod. Po-gata4 transcripts were detected in Sertoli cells, spermatogonia, oogonia and oocytes, with higher transcript levels overall in the testis than the ovary. The promoter region of P. olivaceus R-spondin1was found to contain a GATA4-binding motif. Results of CBA (cleaved amplified polymorphic sequence-based binding assay) indicated that GATA4 could indeed bind to the promoter sequence of R-spondin1. Moreover, human GATA4 recombinant protein could upregulate R-spondin1 in P. olivaceus ovary cells and FBCs (flounder brain cell line). In FBCs, overexpression of Po-gata4 resulted in elevated transcript levels of R-spondin1. Taken together, our results indicate that Po-GATA4 is involved in gonadal development by regulating R-spondin1 expression.
[Mh] Termos MeSH primário: Embrião não Mamífero/metabolismo
Proteínas de Peixes/genética
Linguado/genética
Fator de Transcrição GATA4/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Animais
Sequência de Bases
Linhagem Celular
Embrião não Mamífero/citologia
Embrião não Mamífero/embriologia
Feminino
Proteínas de Peixes/classificação
Proteínas de Peixes/metabolismo
Linguado/embriologia
Linguado/metabolismo
Fator de Transcrição GATA4/classificação
Fator de Transcrição GATA4/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Masculino
Oogônios/citologia
Oogônios/metabolismo
Filogenia
Regiões Promotoras Genéticas/genética
Ligação Proteica
Espermatogônias/citologia
Espermatogônias/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fish Proteins); 0 (GATA4 Transcription Factor)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180115
[St] Status:MEDLINE


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[PMID]:28542174
[Au] Autor:Panchal T; Chen X; Alchits E; Oh Y; Poon J; Kouptsova J; Laski FA; Godt D
[Ad] Endereço:Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Specification and spatial arrangement of cells in the germline stem cell niche of the Drosophila ovary depend on the Maf transcription factor Traffic jam.
[So] Source:PLoS Genet;13(5):e1006790, 2017 May.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Germline stem cells in the Drosophila ovary are maintained by a somatic niche. The niche is structurally and functionally complex and contains four cell types, the escort, cap, and terminal filament cells and the newly identified transition cell. We find that the large Maf transcription factor Traffic jam (Tj) is essential for determining niche cell fates and architecture, enabling each niche in the ovary to support a normal complement of 2-3 germline stem cells. In particular, we focused on the question of how cap cells form. Cap cells express Tj and are considered the key component of a mature germline stem cell niche. We conclude that Tj controls the specification of cap cells, as the complete loss of Tj function caused the development of additional terminal filament cells at the expense of cap cells, and terminal filament cells developed cap cell characteristics when induced to express Tj. Further, we propose that Tj controls the morphogenetic behavior of cap cells as they adopted the shape and spatial organization of terminal filament cells but otherwise appeared to retain their fate when Tj expression was only partially reduced. Our data indicate that Tj contributes to the establishment of germline stem cells by promoting the cap cell fate, and controls the stem cell-carrying capacity of the niche by regulating niche architecture. Analysis of the interactions between Tj and the Notch (N) pathway indicates that Tj and N have distinct functions in the cap cell specification program. We propose that formation of cap cells depends on the combined activities of Tj and the N pathway, with Tj promoting the cap cell fate by blocking the terminal filament cell fate, and N supporting cap cells by preventing the escort cell fate and/or controlling the number of cap cell precursors.
[Mh] Termos MeSH primário: Proteínas de Drosophila/genética
Fatores de Transcrição Maf Maior/genética
Ovário/citologia
Proteínas Proto-Oncogênicas/genética
Nicho de Células-Tronco
[Mh] Termos MeSH secundário: Animais
Drosophila/citologia
Drosophila/genética
Proteínas de Drosophila/metabolismo
Feminino
Fatores de Transcrição Maf Maior/metabolismo
Oogônios/citologia
Oogônios/metabolismo
Ovário/metabolismo
Proteínas Proto-Oncogênicas/metabolismo
Receptores Notch/genética
Receptores Notch/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drosophila Proteins); 0 (Maf Transcription Factors, Large); 0 (Proto-Oncogene Proteins); 0 (Receptors, Notch); 0 (notch protein, Drosophila); 0 (traffic jam protein, Drosophila)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170526
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006790


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[PMID]:28040471
[Au] Autor:Asadi-Azarbaijani B; Santos RR; Jahnukainen K; Braber S; van Duursen MB; Toppari J; Saugstad OD; Nurmio M; Oskam IC
[Ad] Endereço:Women and Children's Division, Oslo University Hospital, Rikshospitalet, Oslo, Norway; University of Oslo, Oslo, Norway. Electronic address: basad@ous-hf.no.
[Ti] Título:Developmental effects of imatinib mesylate on follicle assembly and early activation of primordial follicle pool in postnatal rat ovary.
[So] Source:Reprod Biol;17(1):25-33, 2017 Mar.
[Is] ISSN:2300-732X
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Imatinib mesylate is an anti-cancer agent that competitively inhibits several receptor tyrosine kinases (RTKs). RTKs play important roles in the regulation of primordial follicle formation, the recruitment of primordial follicles into the pool of growing follicles and maturation of the follicles. In the present study, we investigated the effects of the tyrosine kinase inhibitor imatinib on primordial follicle assembly and early folliculogenesis in postnatal rats. Female Sprague-Dawley rats were treated with either imatinib (150mg/kg) or placebo (water) on postnatal days 2-4. Bilateral ovariectomy was performed on postnatal day 2 and 5. Histology, immunohistochemistry, and mRNA analysis were performed. Imatinib treatment was associated with increased density of the multi-oocyte follicles (P<0.01), oogonia (p<0.01) and germline clusters (P<0.05), decreased activation of primordial follicles, increased expression of c-Kit and AMH, and decreased protein expression of Kit-ligand and GDF9 when compared to age-matched controls. In conclusion, imatinib affects folliculogenesis in postnatal rat ovaries by delaying the cluster breakdown, follicular assembly and early activation of the primordial follicle pool.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Regulação da Expressão Gênica no Desenvolvimento/efeitos dos fármacos
Mesilato de Imatinib/farmacologia
Oogênese/efeitos dos fármacos
Células-Tronco de Oogônios/efeitos dos fármacos
Folículo Ovariano/efeitos dos fármacos
Inibidores de Proteínas Quinases/farmacologia
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Hormônio Antimülleriano/química
Hormônio Antimülleriano/genética
Hormônio Antimülleriano/metabolismo
Apoptose/efeitos dos fármacos
Biomarcadores/metabolismo
Feminino
Fator 9 de Diferenciação de Crescimento/antagonistas & inibidores
Fator 9 de Diferenciação de Crescimento/genética
Fator 9 de Diferenciação de Crescimento/metabolismo
Imuno-Histoquímica
Oogônios/citologia
Oogônios/efeitos dos fármacos
Oogônios/metabolismo
Células-Tronco de Oogônios/citologia
Folículo Ovariano/citologia
Folículo Ovariano/crescimento & desenvolvimento
Proteínas Proto-Oncogênicas c-kit/agonistas
Proteínas Proto-Oncogênicas c-kit/genética
Proteínas Proto-Oncogênicas c-kit/metabolismo
RNA Mensageiro/metabolismo
Ratos Sprague-Dawley
Fator de Células-Tronco/antagonistas & inibidores
Fator de Células-Tronco/genética
Fator de Células-Tronco/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Biomarkers); 0 (Growth Differentiation Factor 9); 0 (Protein Kinase Inhibitors); 0 (RNA, Messenger); 0 (Stem Cell Factor); 80497-65-0 (Anti-Mullerian Hormone); 8A1O1M485B (Imatinib Mesylate); EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170102
[St] Status:MEDLINE


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[PMID]:27916703
[Au] Autor:Rahimi M; Bakhtiarizadeh MR; Mohammadi-Sangcheshmeh A
[Ad] Endereço:Department of Animal and Poultry Science, College of Aburaihan, University of Tehran, Tehran, Iran.
[Ti] Título:OOgenesis_Pred: A sequence-based method for predicting oogenesis proteins by six different modes of Chou's pseudo amino acid composition.
[So] Source:J Theor Biol;414:128-136, 2017 Feb 07.
[Is] ISSN:1095-8541
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Regarding to critical roles of oogenesis in formation of ova or unfertilized eggs from the oogonia by mitotic division and subsequent differentiation, the identification of oogenesis-related proteins is of great interest. However, the experimental determination of proteins involved in oogenesis is expensive, time consuming and labor-intensive. Therefore, a new powerful discriminating model is indispensable for classifying oogenesis/non-oogenesis-related proteins with high accuracy and precision. Hereby, for the first time we developed a support vector machine based oogenesis protein prediction method which differentiates oogenesis from non-oogenesis proteins. By means of informative protein physicochemical properties and in addition parameter optimization scheme, our method yields a robust and consistent performance. Our model achieved 87.68% and 84.82% prediction accuracy by five-fold cross validation test for datasets with 90% and 50% identity, respectively. The prediction model was also assessed using the independent dataset and yielded 91.62% and 85.38% prediction accuracy for datasets with 90% and 50% identity, respectively, which further demonstrates the effectiveness of our method. Moreover, by applying 10 different feature weighting methods, the more important protein features for oogenesis/non-oogenesis-related proteins discrimination, including serine and glycine frequency, quasi-sequence-order, pseudo-amino acid composition, distribution and conjoint triad, were determined. The success rates revealed that our model can be considered as a new encouraging and strong model for predicting proteins involved in oogenesis with appropriate performance. To enhance the value of the practical applications of the proposed method, we developed a standalone software for predicting oogenesis candidate proteins called OOgenesis_Pred. This software is the first predictor ever established for identifying oogenesis proteins. We also showed the capability of OOgenesis_Pred by making oogenesis-related proteins prediction for some of the oogenesis candidate proteins. It is anticipated that OOgenesis_Pred will become a powerful tool for future proteomic studies related to oogenesis.
[Mh] Termos MeSH primário: Proteínas de Ciclo Celular
Proteínas do Ovo
Meiose/fisiologia
Oogênese/fisiologia
Oogônios/metabolismo
[Mh] Termos MeSH secundário: Animais
Proteínas de Ciclo Celular/genética
Proteínas de Ciclo Celular/metabolismo
Proteínas do Ovo/genética
Proteínas do Ovo/metabolismo
Feminino
Seres Humanos
Valor Preditivo dos Testes
Análise de Sequência de Proteína
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cell Cycle Proteins); 0 (Egg Proteins)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27715412
[Au] Autor:Chamorro-Rengifo J; Olivier RD; Araujo D
[Ad] Endereço:1 Programa de Pós-Graduação em Biologia Animal, Centro de Ciências Biológicas e da Saúde,Universidade Federal de Mato Grosso do Sul. Campo Grande, Mato Grosso do Sul, Brasil.
[Ti] Título:Bucrates lanista Rehn 1918 (Tettigoniidae: Conocephalinae): The First Record from the Brazilian Pantanal, the First Description of the Male, the First Karyotypic Report for the Genus, and the First Telomeric Hybridization of the Subfamily.
[So] Source:Zoolog Sci;33(5):537-544, 2016 Oct.
[Is] ISSN:0289-0003
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Bucrates lanista, the most southerly distributed species in the genus Bucrates Burmeister, was originally described from Brazil based on a female collected in the state of Rio Grande do Sul, but the species has not been recorded since 1918. In this work, we report that B. lanista inhabits the Pantanal Wetland in the state of Mato Grosso do Sul and, for the first time, describe the male. Individuals of B. lanista are gregarious and present a brown/green color dimorphism; this behavior and color variation are also observed in species of closely related genera. Individuals from the Pantanal vary slightly from those of Rio Grande do Sul. The karyotype was determined to be 2n♂ = 21 = 20 + X0 and 2n♀ = 22 = 20 + XX. The X chromosome is metacentric and the largest of the complement, and all of the autosomes are submetacentrics. All chromosomes solely present telomeric (TTAGG)n repeats at their ends, and some chromosomes present positive and negative DAPI bands.
[Mh] Termos MeSH primário: Cariótipo
Ortópteros/classificação
Ortópteros/genética
[Mh] Termos MeSH secundário: Distribuição Animal
Animais
Brasil
Citogenética
Feminino
Hibridização Genética
Masculino
Oogônios
Ortópteros/fisiologia
Especificidade da Espécie
Espermatozoides
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170309
[Lr] Data última revisão:
170309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


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[PMID]:27622269
[Au] Autor:Klein JD; Qu C; Yang X; Fan Y; Tang C; Peng JC
[Ad] Endereço:Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee, United States of America.
[Ti] Título:c-Fos Repression by Piwi Regulates Drosophila Ovarian Germline Formation and Tissue Morphogenesis.
[So] Source:PLoS Genet;12(9):e1006281, 2016 Sep.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Drosophila melanogaster Piwi functions within the germline stem cells (GSCs) and the somatic niche to regulate GSC self-renewal and differentiation. How Piwi influences GSCs is largely unknown. We uncovered a genetic interaction between Piwi and c-Fos in the somatic niche that influences GSCs. c-Fos is a proto-oncogene that influences many cell and developmental processes. In wild-type ovarian cells, c-Fos is post-transcriptionally repressed by Piwi, which destabilized the c-Fos mRNA by promoting the processing of its 3' untranslated region (UTR) into Piwi-interacting RNAs (piRNAs). The c-Fos 3' UTR was sufficient to trigger Piwi-dependent destabilization of a GFP reporter. Piwi represses c-Fos in the somatic niche to regulate GSC maintenance and differentiation and in the somatic follicle cells to affect somatic cell disorganization, tissue dysmorphogenesis, oocyte maturation arrest, and infertility.
[Mh] Termos MeSH primário: Proteínas Argonauta/genética
Proteínas de Drosophila/genética
Drosophila melanogaster/genética
Regulação da Expressão Gênica no Desenvolvimento
Oogônios/metabolismo
Ovário/crescimento & desenvolvimento
Proteínas Proto-Oncogênicas c-fos/genética
[Mh] Termos MeSH secundário: Regiões 3' não Traduzidas
Animais
Proteínas Argonauta/metabolismo
Proteínas de Drosophila/metabolismo
Drosophila melanogaster/embriologia
Feminino
Oogênese
Oogônios/citologia
Ovário/metabolismo
Proteínas Proto-Oncogênicas c-fos/metabolismo
RNA Interferente Pequeno/genética
RNA Interferente Pequeno/metabolismo
Nicho de Células-Tronco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (3' Untranslated Regions); 0 (Argonaute Proteins); 0 (Drosophila Proteins); 0 (Proto-Oncogene Proteins c-fos); 0 (RNA, Small Interfering); 0 (piwi protein, Drosophila)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160914
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006281


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[PMID]:27418385
[Au] Autor:Uribe MC; Grier HJ; García-Alarcón A; Parenti LR
[Ad] Endereço:Facultad De Ciencias, Departamento De Biología Comparada, Universidad Nacional Autónoma De México, Ciudad De México, 04510, México. mari3uribe3@gmail.com.
[Ti] Título:Oogenesis: From Oogonia to Ovulation in the Flagfish, Jordanella floridae Goode and Bean, 1879 (Teleostei: Cyprinodontidae).
[So] Source:J Morphol;277(10):1339-54, 2016 Oct.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We provide histological details of the development of oocytes in the cyprinodontid flagfish, Jordanella floridae. There are six stages of oogenesis: Oogonial proliferation, chromatin nucleolus, primary growth (previtellogenesis [PG]), secondary growth (vitellogenesis), oocyte maturation and ovulation. The ovarian lamellae are lined by a germinal epithelium composed of epithelial cells and scattered oogonia. During primary growth, the development of cortical alveoli and oil droplets, are initiated simultaneously. During secondary growth, yolk globules coalesce into a fluid mass. The full-grown oocyte contains a large globule of fluid yolk. The germinal vesicle is at the animal pole, and the cortical alveoli and oil droplets are located at the periphery. The disposition of oil droplets at the vegetal pole of the germinal vesicle during late secondary growth stage is a unique characteristic. The follicular cell layer is composed initially of a single layer of squamous cells during early PG which become columnar during early vitellogenesis. During primary and secondary growth stages, filaments develop among the follicular cells and also around the micropyle. The filaments are seen extending from the zona pellucida after ovulation. During ovulation, a space is evident between the oocyte and the zona pellucida. Asynchronous spawning activity is confirmed by the observation that, after ovulation, the ovarian lamellae contain follicles in both primary and secondary growth stages; in contrast, when the seasonal activity of oogenesis and spawning ends, after ovulation, the ovarian lamellae contain only follicles in the primary growth stage. J. Morphol. 277:1339-1354, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Ciclo Estral
Peixes Listrados/anatomia & histologia
Oogênese
Ovulação
[Mh] Termos MeSH secundário: Animais
Feminino
Peixes Listrados/fisiologia
Oócitos/citologia
Oogônios/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.20580


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[PMID]:27210027
[Au] Autor:Wang WC; Lai YC
[Ad] Endereço:Department of Obstetrics and Gynecology, Jen-Ai Hospital, Taichung 402, Taiwan.
[Ti] Título:Genetic analysis results of mature cystic teratomas of the ovary in Taiwan disagree with the previous origin theory of this tumor.
[So] Source:Hum Pathol;52:128-35, 2016 Jun.
[Is] ISSN:1532-8392
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The most accepted theory regarding mature cystic teratomas of the ovary is that they are of parthenogenetic origin from oocyte after the completion of first division. Our previous study demonstrated that the origin of mature cystic teratoma of the uterus is not related to the parthenogenetic process, but is most likely pluripotential stem cell or primordial germ cell before meiosis I. Further studies are needed to clarify the origin of benign mature cystic teratomas of the ovary in Taiwan. In the present study, we investigated the DNA profiles of 9 mature cystic teratomas of the ovary using short tandem repeat analysis with AmpFLSTR SGM Plus, Profiler PCR amplification kits. The methylation statuses of the HhaI sites in the SNRPN, H19DMR, and KvDMR regions were determined on methylation-sensitive multiplex ligation-dependent probe amplification analysis. DNA profiling data from the 9 mature cystic teratomas of the ovary excluded parthenogenetic origin, as most of the 15 short tandem repeat loci were heterozygous on genotyping. There were varying degrees of hypermethylation of SNRPN gene and KvDMR locus in the presence of maternal uniparental disomy in all 9 mature cystic teratomas of the ovary. In light of these results, we further postulated that the origin of these mature cystic teratomas of the ovary is oogonia or primary oocyte before germinal vesicle stage failure of meiosis I.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/genética
Transformação Celular Neoplásica/genética
Metilação de DNA
Repetições de Microssatélites
Neoplasias Císticas, Mucinosas e Serosas/genética
Neoplasias Ovarianas/genética
Teratoma/genética
Proteínas Centrais de snRNP/genética
[Mh] Termos MeSH secundário: Adulto
Transformação Celular Neoplásica/patologia
Feminino
Predisposição Genética para Doença
Impressão Genômica
Heterozigoto
Seres Humanos
Meiose
Reação em Cadeia da Polimerase Multiplex
Neoplasias Císticas, Mucinosas e Serosas/patologia
Oócitos/patologia
Oogônios/patologia
Neoplasias Ovarianas/patologia
Partenogênese
Fenótipo
Canais de Potássio de Abertura Dependente da Tensão da Membrana/genética
Taiwan
Teratoma/patologia
Dissomia Uniparental
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor); 0 (KCNQ1OT1 protein, human); 0 (Potassium Channels, Voltage-Gated); 0 (SNRPN protein, human); 0 (snRNP Core Proteins)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170815
[Lr] Data última revisão:
170815
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160524
[St] Status:MEDLINE


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[PMID]:27098914
[Au] Autor:Daryabeigi A; Woglar A; Baudrimont A; Silva N; Paouneskou D; Vesely C; Rauter M; Penkner A; Jantsch M; Jantsch V
[Ad] Endereço:Department of Chromosome Biology, Max F. Perutz Laboratories, Vienna Biocenter, University of Vienna, 1030, Austria.
[Ti] Título:Nuclear Envelope Retention of LINC Complexes Is Promoted by SUN-1 Oligomerization in the Caenorhabditis elegans Germ Line.
[So] Source:Genetics;203(2):733-48, 2016 Jun.
[Is] ISSN:1943-2631
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:SUN (Sad1 and UNC-84) and KASH (Klarsicht, ANC-1, and Syne homology) proteins are constituents of the inner and outer nuclear membranes. They interact in the perinuclear space via C-terminal SUN-KASH domains to form the linker of nucleoskeleton and cytoskeleton (LINC) complex thereby bridging the nuclear envelope. LINC complexes mediate numerous biological processes by connecting chromatin with the cytoplasmic force-generating machinery. Here we show that the coiled-coil domains of SUN-1 are required for oligomerization and retention of the protein in the nuclear envelope, especially at later stages of female gametogenesis. Consistently, deletion of the coiled-coil domain makes SUN-1 sensitive to unilateral force exposure across the nuclear membrane. Premature loss of SUN-1 from the nuclear envelope leads to embryonic death due to loss of centrosome-nuclear envelope attachment. However, in contrast to previous notions we can show that the coiled-coil domain is dispensable for functional LINC complex formation, exemplified by successful chromosome sorting and synapsis in meiotic prophase I in its absence.
[Mh] Termos MeSH primário: Proteínas de Caenorhabditis elegans/metabolismo
Caenorhabditis elegans/metabolismo
Membrana Nuclear/metabolismo
Oogônios/metabolismo
Multimerização Proteica
Receptores Citoplasmáticos e Nucleares/metabolismo
[Mh] Termos MeSH secundário: Animais
Caenorhabditis elegans/genética
Proteínas de Caenorhabditis elegans/química
Proteínas de Caenorhabditis elegans/genética
Proteínas de Ciclo Celular/genética
Proteínas de Ciclo Celular/metabolismo
Feminino
Meiose
Proteínas Nucleares/genética
Proteínas Nucleares/metabolismo
Ligação Proteica
Domínios Proteicos
Receptores Citoplasmáticos e Nucleares/química
Receptores Citoplasmáticos e Nucleares/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Caenorhabditis elegans Proteins); 0 (Cell Cycle Proteins); 0 (Nuclear Proteins); 0 (Receptors, Cytoplasmic and Nuclear); 0 (Y67H2A.5 protein, C elegans); 0 (sun-1 protein, C elegans)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170504
[Lr] Data última revisão:
170504
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1534/genetics.116.188094


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[PMID]:26791142
[Au] Autor:Kaku H; Usui H; Qu J; Shozu M
[Ad] Endereço:Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
[Ti] Título:Mature cystic teratomas arise from meiotic oocytes, but not from pre-meiotic oogonia.
[So] Source:Genes Chromosomes Cancer;55(4):355-64, 2016 Apr.
[Is] ISSN:1098-2264
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mature cystic teratomas (MCTs) in the ovaries have been thought to originate from germ cells from all developmental stages, i.e., from pre-meiotic oogonia through meiotic oocytes to mature post-meiotic ova. This view was based on research on MCTs by classical methods, including those involving centromeric heteromorphisms in karyotypes, enzyme polymorphisms, and DNA polymorphisms. However, insufficient genomic information was obtained in those studies. The current study aimed to confirm the cytogenetic origin of ovarian MCTs by using short tandem repeat (STR) polymorphism analysis to obtain sufficient genomic information, especially in connection with centromeric loci. Tissue samples of MCTs (57 ovaries from 51 patients, 91 MCTs, 156 specimens in total) obtained from cystectomies or oophorectomies were used. We categorized the specimens into two groups: i) solid components of MCTs and ii) cyst walls. The numbers of solid components of MCTs from pre-meiotic oogonia, primary oocytes, secondary oocytes, and ova were 0, 33, 16, and 15, respectively. There were no pre-meiotic oogonia in this series of solid-component specimens. We propose a hypothesis for the tumorigenesis of ovarian MCTs: the precursors of ovarian MCTs are not functional oocytes or ova, but are primary oocytes that have escaped from meiotic arrest. This hypothesis could satisfactorily explain the lack of pre-meiotic teratomas observed in this study and the nearly equal distribution of teratomas originating from primary oocytes, secondary oocytes, and ova in previous studies. Furthermore, this hypothesis could provide a starting point for determining the mechanism underlying tumorigenesis of ovarian MCTs.
[Mh] Termos MeSH primário: Oócitos/patologia
Oogônios/patologia
Neoplasias Ovarianas/patologia
Teratoma/patologia
[Mh] Termos MeSH secundário: Transformação Celular Neoplásica/genética
Centrômero
Feminino
Seres Humanos
Meiose
Células-Tronco Neoplásicas
Neoplasias Ovarianas/genética
Teratoma/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160211
[Lr] Data última revisão:
160211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160122
[St] Status:MEDLINE
[do] DOI:10.1002/gcc.22339



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