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[PMID]:29175396
[Au] Autor:Wang F; Liu F; Chen W; Xu R; Wang W
[Ad] Endereço:School of Biological Science, Luoyang Normal University, Luoyang, 471022, China; Cold Water Fish Breeding Engineering Technology Research Center of Henan Province, Luoyang, 471022, China. Electronic address: wangfan7677@163.com.
[Ti] Título:Effects of triclosan (TCS) on hormonal balance and genes of hypothalamus-pituitary- gonad axis of juvenile male Yellow River carp (Cyprinus carpio).
[So] Source:Chemosphere;193:695-701, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Triclosan (TCS) is a broad spectrum antimicrobial agent which has been widely dispersed and determinated in the aquatic environment. However, the effects of TCS on reproductive endocrine in male fish are poorly understood. In this study, male Yellow River carp (Cyprinus carpio) were exposed to 0, 1/5, 1/10 and 1/20 LC (96 h LC of TCS to carp) TCS under semi-static conditions for 42 d. Vitellogenin (Vtg), 17ß-estradiol (E ), testosterone(T), gonadotropin (GtH), and gonadotropin-releasing hormone (GnRH) levels were measured by enzyme-linked immunosorbent assay (ELISA). Meanwhile, we also examined the mRNA expressions of aromatase, GtHs-ß, GnRH, estrogen receptor (Er), and androgen receptor (Ar) by quantitative Real-time Polymerase Chain Reaction (qRT-PCR). TCS induced Vtg levels of hepatopancreas, E levels of serum, and inhibited Ar and Er mRNA levels, suggesting that the induction of Vtg production by TCS was indirectly caused by non-Er pathways. TCS-induced Vtg levels by interfering with the reproductive axis at plenty of latent loci of male carps: (a) TCS exposure increased the aromatase mRNA expression of hypothalamus and gonad aromatase, consequently increasing serum concentrations of E to induce Vtg in hepatopancreas; (b) TCS treatment changed GtH-ß and GnRH mRNA expression and secretion, causing the disturbance of reproductive endocrine; (c) TCS exposure decreased Ar mRNA levels, indicating potential Ar-mediated antiandrogen action. These mechanisms showed that TCS may induce Vtg production in male carp by non-Er-mediated pathways.
[Mh] Termos MeSH primário: Carpas/metabolismo
Triclosan/toxicidade
Poluentes Químicos da Água/toxicidade
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/toxicidade
Aromatase/genética
Sistema Endócrino/efeitos dos fármacos
Ensaio de Imunoadsorção Enzimática
Estradiol/análise
Hormônio Liberador de Gonadotropina/análise
Hormônio Liberador de Gonadotropina/genética
Gônadas/enzimologia
Gônadas/metabolismo
Hepatopâncreas/metabolismo
Hormônios/metabolismo
Hipotálamo/metabolismo
Masculino
Hipófise/metabolismo
RNA Mensageiro/análise
Reação em Cadeia da Polimerase em Tempo Real
Receptores Estrogênicos/genética
Reprodução/efeitos dos fármacos
Testosterona/análise
Vitelogeninas/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Hormones); 0 (RNA, Messenger); 0 (Receptors, Estrogen); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 33515-09-2 (Gonadotropin-Releasing Hormone); 3XMK78S47O (Testosterone); 4NM5039Y5X (Triclosan); 4TI98Z838E (Estradiol); EC 1.14.14.1 (Aromatase); EC 1.14.14.1 (CYP19A1 protein, human)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28972920
[Au] Autor:Park K; Kwak IS
[Ad] Endereço:Faculty of Marine Technology, Chonnam National University, Yeosu 550-749, South Korea.
[Ti] Título:Disrupting effects of antibiotic sulfathiazole on developmental process during sensitive life-cycle stage of Chironomus riparius.
[So] Source:Chemosphere;190:25-34, 2018 Jan.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Antibiotics in the environment are a concern due to their potential to harm humans and interrupt ecosystems. Sulfathiazole (STZ), a sulfonamide antibiotic, is commonly used in aquaculture and is typically found in aquatic ecosystems. We evaluated the ecological risk of STZ by examining biological, molecular and biochemical response in Chironomus riparius. Samples were exposed to STZ for 12, 24 and 96 h, and effects of STZ were evaluated at the molecular level by analyzing changes in gene expression related to the endocrine system, cellular stress response and enzyme activity of genes on antioxidant and detoxification pathways. STZ exposure induced significant effects on survival, growth and sex ratio of emergent adults and mouthpart deformity in C. riparius. STZ caused concentration and time-dependent toxicity in most of the selected biomarkers. STZ exposure leads to significant heat-shock response of protein genes (HSP70, HSP40, HSP90 and HSP27) and to disruption by up-regulating selected genes, including the ecdysone receptor gene, estrogen-related receptors, ultraspiracle and E74 early ecdysone-responsive gene. Furthermore, STZ induced alteration of enzyme activities on antioxidant and detoxification responses (catalase, superoxide dismutase, glutathione peroxidase and peroxidase) in C. riparius. By inducing oxidative stress, antibiotic STZ disturbs the endocrine system and produces adverse effects in growth processes of invertebrates.
[Mh] Termos MeSH primário: Chironomidae/efeitos dos fármacos
Expressão Gênica/efeitos dos fármacos
Estágios do Ciclo de Vida/efeitos dos fármacos
Sulfatiazóis/toxicidade
[Mh] Termos MeSH secundário: Animais
Antibacterianos/farmacologia
Antibacterianos/toxicidade
Chironomidae/crescimento & desenvolvimento
Ecdisona/metabolismo
Sistema Endócrino/efeitos dos fármacos
Sistema Endócrino/metabolismo
Proteínas de Choque Térmico HSP70/metabolismo
Resposta ao Choque Térmico/efeitos dos fármacos
Inativação Metabólica/efeitos dos fármacos
Receptores de Esteroides/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (HSP70 Heat-Shock Proteins); 0 (Receptors, Steroid); 0 (Sulfathiazoles); 0 (ecdysone receptor); 3604-87-3 (Ecdysone); Y7FKS2XWQH (sulfathiazole)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE


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[PMID]:29405681
[Au] Autor:Dolomatov S; Sataieva T; Pazovsky G; Zukow W
[Ti] Título:[Neuroendocrine effects of helminthiases (A review)].
[So] Source:Parazitologiia;51(2):97-103, 2017 Mar-Apr.
[Is] ISSN:0031-1847
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Nowadays the number of patients diagnosed with helminthiases shows tendency for steady growth around the world. During last few years, researches in the field of immunology have again turned their attention towards the question of parasitological immunity and tissue response. Helminthiases and other parasitic diseases in some instances can induce central nervous system disorders and violate human behavioral reactions. Studies have suggested an association between epilepsy and helminth infection, but a causal relationship is not established in many helminths, except perhaps with neurocysticercosis. The aim of this review is to reveal details of specific mechanisms of the general helminths' impact on the nervous system and the endocrine control level of physiological functions of the host organism. Finally, we discuss the current gaps in knowledge about the interaction between helminths, immunity, and human endocrine system. Key words: helminths, immunity, hormones, cytokines.
[Mh] Termos MeSH primário: Sistema Endócrino/imunologia
Epilepsia/imunologia
Interações Hospedeiro-Parasita/imunologia
Sistema Nervoso/imunologia
Neurocisticercose/imunologia
[Mh] Termos MeSH secundário: Animais
Citocinas/imunologia
Citocinas/metabolismo
Sistema Endócrino/metabolismo
Sistema Endócrino/parasitologia
Epilepsia/complicações
Epilepsia/metabolismo
Epilepsia/parasitologia
Helmintos/patogenicidade
Helmintos/fisiologia
Hormônios/imunologia
Hormônios/metabolismo
Seres Humanos
Imunidade Inata
Sistema Nervoso/metabolismo
Sistema Nervoso/parasitologia
Neurocisticercose/complicações
Neurocisticercose/metabolismo
Neurocisticercose/parasitologia
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Cytokines); 0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE


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[PMID]:29051074
[Au] Autor:Shero MR; Bergfelt DR; Testa JW; Adams GP
[Ad] Endereço:Department of Biological Sciences, University of Alaska Anchorage, 3101 Science Circle, Anchorage, AK 99508-4614, USA. Electronic address: mrshero@alaska.edu.
[Ti] Título:Pairing ultrasonography with endocrinology to elucidate underlying mechanisms of successful pregnancy in the northern fur seal (Callorhinus ursinus).
[So] Source:Gen Comp Endocrinol;255:78-89, 2018 Jan 01.
[Is] ISSN:1095-6840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reproductive success is one of the central tenets of conservation management programs, yet the inability to study underlying physiological processes in a minimally-invasive manner and the unpredictable nature of wild animal populations leaves large gaps in our knowledge of factors critical to successful reproduction in wild species. This study integrated ultrasonography of the reproductive tract and analysis of reproductive hormones in 172 northern fur seals (Callorhinus ursinus) to identify intrinsic factors associated with reinitiating embryonic growth at the end of diapause. Within the first 3-4 weeks of active gestation, pregnant fur seals (n = 126) had a larger corpus luteum and fewer antral follicles than non-pregnant fur seals, or those still in diapause (n = 46). This suggests that the conceptus drives changes in ovarian status to convey its presence to the female. Morphological changes in the reproductive tract associated with pregnancy were not reflected in differences in endocrine profiles (estradiol, estrone, progesterone, and relaxin) between pregnant and non-pregnant individuals. Hormone concentrations correlated more strongly with calendar date than with the presence or size of the conceptus, demonstrating that none of these reproductive hormones were reliable markers for early pregnancy diagnosis. Instead, the northern fur seal's long diestrus may serve to reduce the probability of a temporal mismatch between corpus luteum regression and embryo implantation. Indeed, conception rates were high and confirmed rates of pregnancy loss were relatively low (11%). In this study, minimally-invasive ultrasonography was used in wild pinnipeds to detect very early pregnancy (embryonic vesicles >2 mm) in combination with ovarian and endocrine dynamics at the time of embryo implantation, shedding light on mechanisms for maternal recognition of pregnancy. This study is also the first to track whether these same animals carried the embryo to term, by observing fur seals during the birthing season the following year. Data do not support the notion that decreased pregnancy rates or higher pregnancy loss rates are major contributing factors to the northern fur seal's population decline.
[Mh] Termos MeSH primário: Sistema Endócrino/metabolismo
Otárias/fisiologia
Ultrassonografia
[Mh] Termos MeSH secundário: Animais
Embrião de Mamíferos/fisiologia
Feminino
Otárias/embriologia
Hormônios/metabolismo
Modelos Lineares
Masculino
Ovário/anatomia & histologia
Ovário/diagnóstico por imagem
Gravidez
Reprodução
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hormones)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171021
[St] Status:MEDLINE


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[PMID]:29112878
[Au] Autor:Liu G; Ke M; Fan X; Zhang M; Zhu Y; Lu T; Sun L; Qian H
[Ad] Endereço:College of Environment, Zhejiang University of Technology, Hangzhou, 310032, PR China; Department of Food Science and Technology, Zhejiang University of Technology, Hangzhou, 310032, PR China.
[Ti] Título:Reproductive and endocrine-disrupting toxicity of Microcystis aeruginosa in female zebrafish.
[So] Source:Chemosphere;192:289-296, 2018 Feb.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Microcystis aeruginosa, a primary species in cyanobacterial blooms, is ubiquitously distributed in water. Microcystins (MCs) purified from M. aeruginosa can exert reproductive toxicity in fish. However, the effects of M. aeruginosa at environmentally relevant levels on the reproductive and endocrine systems of zebrafish are still unknown. The present study investigated the reproductive and endocrine-disrupting toxicity of M. aeruginosa on female zebrafish (Danio rerio) by short-term exposure (96 h). After exposure, marked histological lesions in the liver or gonads, such as nuclear pyknosis and deformation, were observed, and the fertilization rate and hatchability of eggs spawned from treated females were both significantly lower than they were in females in the control group, suggesting the possibility of transgenerational effects of M. aeruginosa exposure. Moreover, M. aeruginosa exposure decreased the concentration of 17ß-estradiol (E2) and testosterone (T) in female zebrafish. Interestingly, the vtg1 transcriptional level significantly decreased in the liver, whereas plasma vitellogenin (VTG) protein levels increased. The present findings indicate that M. aeruginosa could modulate endocrine function by disrupting transcription of hypothalamic-pituitary-gonadal-liver (HPGL) axis-related genes, and impair the reproductive capacity of female zebrafish, suggesting that M. aeruginosa causes potential adverse effects on fish reproduction in Microcystis bloom-contaminated aquatic environments.
[Mh] Termos MeSH primário: Sistema Endócrino/efeitos dos fármacos
Microcistinas/toxicidade
Microcystis/patogenicidade
Reprodução/efeitos dos fármacos
Peixe-Zebra/microbiologia
[Mh] Termos MeSH secundário: Animais
Toxinas Bacterianas/farmacologia
Disruptores Endócrinos/farmacologia
Estradiol/análise
Estradiol/metabolismo
Feminino
Gônadas/efeitos dos fármacos
Gônadas/metabolismo
Gônadas/patologia
Fígado/efeitos dos fármacos
Fígado/metabolismo
Fígado/patologia
Microcistinas/isolamento & purificação
Microcystis/metabolismo
Testosterona/análise
Testosterona/sangue
Vitelogeninas/sangue
Vitelogeninas/metabolismo
Poluentes Químicos da Água/toxicidade
Peixe-Zebra/metabolismo
Peixe-Zebra/fisiologia
Proteínas de Peixe-Zebra/análise
Proteínas de Peixe-Zebra/efeitos dos fármacos
Proteínas de Peixe-Zebra/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bacterial Toxins); 0 (Endocrine Disruptors); 0 (Microcystins); 0 (Vitellogenins); 0 (Water Pollutants, Chemical); 0 (Zebrafish Proteins); 3XMK78S47O (Testosterone); 4TI98Z838E (Estradiol); 77238-39-2 (microcystin)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171108
[St] Status:MEDLINE


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[PMID]:29317319
[Au] Autor:Shafei A; Ramzy MM; Hegazy AI; Husseny AK; El-Hadary UG; Taha MM; Mosa AA
[Ad] Endereço:Biomedical Research Department, Armed Forces College of Medicine (AFCM), Cairo, Egypt.
[Ti] Título:The molecular mechanisms of action of the endocrine disrupting chemical bisphenol A in the development of cancer.
[So] Source:Gene;647:235-243, 2018 Mar 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The endocrine disrupting chemical (EDC) is an exogenous substance or mixture that alters the function of the endocrine system and consequently causes adverse effects in intact organisms. Bisphenol A (BPA), one of the most common endocrine disrupting chemicals is a carbon-based synthetic compound used in the production of water bottles, cans, and teeth suture materials. It is known to be a xenoestrogen as it interacts with estrogen receptors and acts as agonist or antagonist via estrogen receptor-dependent signaling pathways. BPA has been associated with serious health effects in humans and wildlife. It elicits several endocrine disorders and plays a role in the pathogenesis of several hormone-dependent tumors such as breast, ovarian, prostate cancer and others. More complicate to this picture, its effects rely on several and diverse molecular and epigenetic mechanisms that converge upon endocrine and reproductive systems. The present review gives an overview of general hazards of BPA, its epigenetic modifications and the molecular mechanisms of BPA action in different types of cancers as the increase in information about responses and action mechanisms of BPA may bring a better understanding of the risks of BPA exposure in humans and provide an important platform on which human health can be improved.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/farmacologia
Carcinogênese/induzido quimicamente
Disruptores Endócrinos/farmacologia
Sistema Endócrino/efeitos dos fármacos
Neoplasias/induzido quimicamente
Fenóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Carcinogênese/genética
Epigênese Genética/genética
Seres Humanos
Neoplasias/genética
Receptores Estrogênicos/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Endocrine Disruptors); 0 (Phenols); 0 (Receptors, Estrogen); MLT3645I99 (bisphenol A)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180209
[Lr] Data última revisão:
180209
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180111
[St] Status:MEDLINE


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[PMID]:29246165
[Au] Autor:Sonne C; Letcher RJ; Jenssen BM; Desforges JP; Eulaers I; Andersen-Ranberg E; Gustavson K; Styrishave B; Dietz R
[Ad] Endereço:Department of Bioscience, Arctic Research Centre (ARC), Aarhus University, Faculty of Science and Technology, Frederiksborgvej 399, PO Box 358, 4000, Roskilde, Denmark. cs@bios.au.dk.
[Ti] Título:A veterinary perspective on One Health in the Arctic.
[So] Source:Acta Vet Scand;59(1):84, 2017 Dec 16.
[Is] ISSN:1751-0147
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Exposure to long-range transported industrial chemicals, climate change and diseases is posing a risk to the overall health and populations of Arctic wildlife. Since local communities are relying on the same marine food web as marine mammals in the Arctic, it requires a One Health approach to understand the holistic ecosystem health including that of humans. Here we collect and identify gaps in the current knowledge of health in the Arctic and present the veterinary perspective of One Health and ecosystem dynamics. The review shows that exposure to persistent organic pollutants (POPs) is having multiple organ-system effects across taxa, including impacts on neuroendocrine disruption, immune suppression and decreased bone density among others. Furthermore, the warming Arctic climate is suspected to influence abiotic and biotic long-range transport and exposure pathways of contaminants to the Arctic resulting in increases in POP exposure of both wildlife and human populations. Exposure to vector-borne diseases and zoonoses may increase as well through range expansion and introduction of invasive species. It will be important in the future to investigate the effects of these multiple stressors on wildlife and local people to better predict the individual-level health risks. It is within this framework that One Health approaches offer promising opportunities to survey and pinpoint environmental changes that have effects on wildlife and human health.
[Mh] Termos MeSH primário: Saúde Única
[Mh] Termos MeSH secundário: Animais
Regiões Árticas
Mudança Climática
Sistema Endócrino/efeitos dos fármacos
Poluentes Ambientais/toxicidade
Seres Humanos
Zoonoses/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Environmental Pollutants)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1186/s13028-017-0353-5


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[PMID]:27776987
[Au] Autor:Guadalupe-Grau A; Carnicero JA; Losa-Reyna J; Tresguerres J; Gómez-Cabrera MD; Castillo C; Alfaro-Acha A; Rosado-Artalejo C; Rodriguez-Mañas L; García-García FJ
[Ad] Endereço:ImFINE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences-INEF, Technical University of Madrid, Madrid, Spain; Hospital Virgen del Valle (Complejo Hospitalario de Toledo), Red Española de Investigación en Fragilidad y Envejecimiento (RETICEF),
[Ti] Título:Endocrinology of Aging From a Muscle Function Point of View: Results From the Toledo Study for Healthy Aging.
[So] Source:J Am Med Dir Assoc;18(3):234-239, 2017 Mar 01.
[Is] ISSN:1538-9375
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Aging is a process that involves a reduction in muscle strength and anabolic hormone concentrations, which impacts significantly on health. AIM: To study the hormone/total strength (H/TS) ratio as a proxy of anabolic insensitivity status in elders, and its relationship with disability, hospitalization, and mortality risk. DESIGN: A total of 1462 persons aged ≥65 years from the Toledo Study of Healthy Aging participated in this study. Serum concentrations of insulin like growth factor 1, total and free testosterone, dehydroepiandrosterone, dehydroepiandrosterone sulfate, and 17ß-estradiol were measured. Total maximal voluntary isometric strength was obtained (handgrip, shoulder, hip, and knee) using standardized techniques and equipment. Physical activity was recorded by physical activity scale for the elderly questionnaire. Associations of the H/TS ratio with hospitalization and mortality were assessed using logistic regression models, and participants stratified into quartiles for each H/TS ratio. RESULTS: In women, all individual ratio H/TS models showed a strong to moderate increased risk for death and hospitalization. In men, all models revealed a significant positive association of the ratio H/TS with mortality rate but not for hospitalization (P < .01). Participants who have 2 or more H/TS ratios in the worst quartile increased the risk of hospitalization and mortality at least by 2-fold. CONCLUSIONS: We demonstrate the main role that muscle function plays in the relationship between the hormonal status and hospitalization and mortality risk; this could be taken into consideration as a way to classify patients for hormonal therapy.
[Mh] Termos MeSH primário: Sistema Endócrino/metabolismo
Envelhecimento Saudável
Força Muscular/fisiologia
Músculo Esquelético/metabolismo
Músculo Esquelético/fisiologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Hospitalização
Seres Humanos
Masculino
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171221
[Lr] Data última revisão:
171221
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28873415
[Au] Autor:Theriau CF; Sauvé OS; Beaudoin MS; Wright DC; Connor MK
[Ad] Endereço:School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, ON, Canada.
[Ti] Título:Proliferative endocrine effects of adipose tissue from obese animals on MCF7 cells are ameliorated by resveratrol supplementation.
[So] Source:PLoS One;12(9):e0183897, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Obesity is clearly associated with an increased risk of breast cancer in postmenopausal women. The purpose was to determine if obesity alters the adipocyte adipokine secretion profile, thereby altering the adipose-dependent paracrine/endocrine growth microenvironment surrounding breast cancer cells (MCF7). Additionally, we determined whether resveratrol (RSV) supplementation can counteract any obesity-dependent effects on breast cancer tumor growth microenvironment. Obese ZDF rats received standard chow diet or diet supplemented with 200 mg/kg body weight RSV. Chow-fed Zucker rats served as lean controls. After 6 weeks, conditioned media (CM) prepared from inguinal subcutaneous adipose tissue (scAT) was added to MCF7 cells for 24 hrs. Experiments were also conducted using purified isolated adipocytes to determine whether any endocrine effects could be attributed specifically to the adipocyte component of adipose tissue. scAT from ZDF rats promoted cell cycle entry in MCF7 cells which was counteracted by RSV supplementation. RSV-CM had a higher ratio of ADIPO:LEP compared to ZDF-CM. This altered composition of the CM led to increased levels of pAMPKT172, p27, p27T198 and AdipoR1 while decreasing pAktT308 in MCF7 cells grown in RSV-CM compared to ZDF-CM. RSV-CM increased number of cells in G0/G1 and decreased cells in S-phase compared to ZDF-CM. Co-culture experiments revealed that these obesity-dependent effects were driven by the adipocyte component of the adipose tissue. Obesity decreased the ratio of adiponectin:leptin secreted by adipocytes, altering the adipose-dependent growth microenvironment resulting in increased breast cancer cell proliferation. Supplementation with RSV reversed these adipose-dependent effects suggesting a potential for RSV as a nutritional supplementation to improve breast cancer treatment in obese patients.
[Mh] Termos MeSH primário: Adipócitos/citologia
Meios de Cultivo Condicionados/química
Obesidade/complicações
Estilbenos/farmacologia
[Mh] Termos MeSH secundário: Adipocinas/metabolismo
Tecido Adiposo/metabolismo
Animais
Peso Corporal
Neoplasias da Mama/patologia
Ciclo Celular
Proliferação Celular
Técnicas de Cocultura
Sistema Endócrino
Feminino
Seres Humanos
Células MCF-7
Masculino
Obesidade/patologia
Ratos
Ratos Zucker
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adipokines); 0 (Culture Media, Conditioned); 0 (Stilbenes); Q369O8926L (resveratrol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171025
[Lr] Data última revisão:
171025
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170906
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183897


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[PMID]:28855400
[Au] Autor:Mosconi L; Berti V; Quinn C; McHugh P; Petrongolo G; Varsavsky I; Osorio RS; Pupi A; Vallabhajosula S; Isaacson RS; de Leon MJ; Brinton RD
[Ad] Endereço:From the Departments of Neurology (L.M., R.S.I.) and Radiology (S.V.), Weill Cornell Medical College; Department of Psychiatry (L.M., C.Q., P.M., G.P., I.V., R.S.O., M.J.d.L.), New York University School of Medicine, New York; Department of Biomedical, Experimental and Clinical Sciences "Mario Serio
[Ti] Título:Sex differences in Alzheimer risk: Brain imaging of endocrine vs chronologic aging.
[So] Source:Neurology;89(13):1382-1390, 2017 Sep 26.
[Is] ISSN:1526-632X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: This observational multimodality brain imaging study investigates emergence of endophenotypes of late-onset Alzheimer disease (AD) risk during endocrine transition states in a cohort of clinically and cognitively normal women and age-matched men. METHODS: Forty-two 40- to 60-year-old cognitively normal women (15 asymptomatic perimenopausal by age [CNT], 13 perimenopausal [PERI], and 14 postmenopausal [MENO]) and 18 age- and education-matched men were examined. All patients had volumetric MRI, F-fluoro-2-deoxyglucose (FDG)-PET (glucose metabolism), and Pittsburgh compound B-PET scans (ß-amyloid [Aß] deposition, a hallmark of AD pathology). RESULTS: As expected, the MENO group was older than the PERI and CNT groups. Otherwise, groups were comparable on clinical and neuropsychological measures and distribution. Compared to CNT women and to men, and controlling for age, PERI and MENO groups exhibited increased indicators of AD endophenotype, including hypometabolism, increased Aß deposition, and reduced gray and white matter volumes in AD-vulnerable regions ( < 0.001). AD biomarker abnormalities were greatest in MENO, intermediate in PERI, and lowest in CNT women ( < 0.001). Aß deposition was exacerbated in -positive MENO women relative to the other groups ( < 0.001). CONCLUSIONS: Multimodality brain imaging indicates sex differences in development of the AD endophenotype, suggesting that the preclinical AD phase is early in the female aging process and coincides with the endocrine transition of perimenopause. These data indicate that the optimal window of opportunity for therapeutic intervention in women is early in the endocrine aging process.
[Mh] Termos MeSH primário: Envelhecimento/metabolismo
Envelhecimento/patologia
Doença de Alzheimer/diagnóstico por imagem
Doença de Alzheimer/metabolismo
Encéfalo/diagnóstico por imagem
Caracteres Sexuais
[Mh] Termos MeSH secundário: Adulto
Doença de Alzheimer/epidemiologia
Doença de Alzheimer/genética
Apolipoproteínas E/genética
Biomarcadores/metabolismo
Encéfalo/metabolismo
Sistema Endócrino/metabolismo
Endofenótipos
Feminino
Fluordesoxiglucose F18
Glucose/metabolismo
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Menopausa/metabolismo
Meia-Idade
Imagem Multimodal
Tamanho do Órgão
Tomografia por Emissão de Pósitrons
Compostos Radiofarmacêuticos
Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Apolipoproteins E); 0 (Biomarkers); 0 (Radiopharmaceuticals); 0Z5B2CJX4D (Fluorodeoxyglucose F18); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171029
[Lr] Data última revisão:
171029
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1212/WNL.0000000000004425



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