Base de dados : MEDLINE
Pesquisa : A06.688 [Categoria DeCS]
Referências encontradas : 9143 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 915 ir para página                         

  1 / 9143 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29065796
[Au] Autor:Cyr KJ; Avaldi OM; Wikswo JP
[Ad] Endereço:1 Vanderbilt Institute for Integrative Biosystems Research and Education.
[Ti] Título:Circadian hormone control in a human-on-a-chip: In vitro biology's ignored component?
[So] Source:Exp Biol Med (Maywood);242(17):1714-1731, 2017 Nov.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Organs-on-Chips (OoCs) are poised to reshape dramatically the study of biology by replicating in vivo the function of individual and coupled human organs. Such microphysiological systems (MPS) have already recreated complex physiological responses necessary to simulate human organ function not evident in two-dimensional in vitro biological experiments. OoC researchers hope to streamline pharmaceutical development, accelerate toxicology studies, limit animal testing, and provide new insights beyond the capability of current biological models. However, to develop a physiologically accurate Human-on-a-Chip, i.e., an MPS homunculus that functions as an interconnected, whole-body, model organ system, one must couple individual OoCs with proper fluidic and metabolic scaling. This will enable the study of the effects of organ-organ interactions on the metabolism of drugs and toxins. Critical to these efforts will be the recapitulation of the complex physiological signals that regulate the endocrine, metabolic, and digestive systems. To date, with the exception of research focused on reproductive organs on chips, most OoC research ignores homuncular endocrine regulation, in particular the circadian rhythms that modulate the function of all organ systems. We outline the importance of cyclic endocrine regulation and the role that it may play in the development of MPS homunculi for the pharmacology, toxicology, and systems biology communities. Moreover, we discuss the critical end-organ hormone interactions that are most relevant for a typical coupled-OoC system, and the possible research applications of a missing endocrine system MicroFormulator (MES-µF) that could impose biological rhythms on in vitro models. By linking OoCs together through chemical messenger systems, advanced physiological phenomena relevant to pharmacokinetics and pharmacodynamics studies can be replicated. The concept of a MES-µF could be applied to other standard cell-culture systems such as well plates, thereby extending the concept of circadian hormonal regulation to much of in vitro biology. Impact statement Historically, cyclic endocrine modulation has been largely ignored within in vitro cell culture, in part because cultured cells typically have their media changed every day or two, precluding hourly adjustment of hormone concentrations to simulate circadian rhythms. As the Organ-on-Chip (OoC) community strives for greater physiological realism, the contribution of hormonal oscillations toward regulation of organ systems has been examined only in the context of reproductive organs, and circadian variation of the breadth of other hormones on most organs remains unaddressed. We illustrate the importance of cyclic endocrine modulation and the role that it plays within individual organ systems. The study of cyclic endocrine modulation within OoC systems will help advance OoC research to the point where it can reliably replicate in vitro key regulatory components of human physiology. This will help translate OoC work into pharmaceutical applications and connect the OoC community with the greater pharmacology and physiology communities.
[Mh] Termos MeSH primário: Relógios Circadianos/fisiologia
Ritmo Circadiano/fisiologia
Glândulas Endócrinas/fisiologia
Procedimentos Analíticos em Microchip/métodos
Sistemas Neurossecretores/fisiologia
[Mh] Termos MeSH secundário: Seres Humanos
Dispositivos Lab-On-A-Chip
Modelos Biológicos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1177/1535370217732766


  2 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28916169
[Au] Autor:Gu T; Zhao T; Kohli U; Hewes RS
[Ad] Endereço:Department of Biology, University of Oklahoma, Norman, OK 73019, USA.
[Ti] Título:The large and small SPEN family proteins stimulate axon outgrowth during neurosecretory cell remodeling in Drosophila.
[So] Source:Dev Biol;431(2):226-238, 2017 11 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Split ends (SPEN) is the founding member of a well conserved family of nuclear proteins with critical functions in transcriptional regulation and the post-transcriptional processing and nuclear export of transcripts. In animals, the SPEN proteins fall into two size classes that perform either complementary or antagonistic functions in different cellular contexts. Here, we show that the two Drosophila representatives of this family, SPEN and Spenito (NITO), regulate metamorphic remodeling of the CCAP/bursicon neurosecretory cells. CCAP/bursicon cell-targeted overexpression of SPEN had no effect on the larval morphology or the pruning back of the CCAP/bursicon cell axons at the onset of metamorphosis. During the subsequent outgrowth phase of metamorphic remodeling, overexpression of either SPEN or NITO strongly inhibited axon extension, axon branching, peripheral neuropeptide accumulation, and soma growth. Cell-targeted loss-of-function alleles for both spen and nito caused similar reductions in axon outgrowth, indicating that the absolute levels of SPEN and NITO activity are critical to support the developmental plasticity of these neurons. Although nito RNAi did not affect SPEN protein levels, the phenotypes produced by SPEN overexpression were suppressed by nito RNAi. We propose that SPEN and NITO function additively or synergistically in the CCAP/bursicon neurons to regulate multiple aspects of neurite outgrowth during metamorphic remodeling.
[Mh] Termos MeSH primário: Proteínas de Drosophila/metabolismo
Drosophila melanogaster/metabolismo
Família Multigênica
Crescimento Neuronal
Sistemas Neurossecretores/citologia
Sistemas Neurossecretores/metabolismo
[Mh] Termos MeSH secundário: Animais
Larva/metabolismo
Neurônios/metabolismo
Neurossecreção
Terminações Pré-Sinápticas/metabolismo
Interferência de RNA
Asas de Animais/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Drosophila Proteins)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171111
[Lr] Data última revisão:
171111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE


  3 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28911972
[Au] Autor:Kasten-Jolly J; Lawrence DA
[Ad] Endereço:Wadsworth Center, New York State Department of Health University at Albany School of Public Health, Albany, NY, United States.
[Ti] Título:Sex-specific effects of developmental lead exposure on the immune-neuroendocrine network.
[So] Source:Toxicol Appl Pharmacol;334:142-157, 2017 Nov 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The environmental toxicant lead (Pb) has long been known to induce neurological deficits. The 1st century Greek physician Pedanius Dioscorides noted that "lead makes the mind give way". Current studies are suggesting the effects of Pb on behaviors may involve the immune system and conversely some immunomodulatory changes may be due to Pb effects in the central nervous system. Although Pb-induced disorders do not appear to discriminate among females and males, this report discusses the differences observed in human and animal studies regarding differential gender effects on gene expression after Pb exposure. The overall ill health outcomes are apparent with variant levels of Pb exposure and exposures at different times in development. However, the consensus is that doses leading to blood lead levels>5µg/dl and prenatal exposures are most pathogenic. Although the general detriments induced by Pb may be similar in females and males, there are sex specific outcomes on health and behavior. It is suggested that Pb induces more oxidative stress in females and more upregulation of genes responding to oxidative stress, while males have more proteolytic destruction; but in both cases, there is generation of altered/denatured self-constituents causing inflammation and loss of homeostasis of neuronal and immune functions. The higher estrogen levels of females are indicated as the reason for more Pb-induced reactive oxygen species in females. This review describes some of the different genes involved in female and male responses to Pb exposure and involved pathways.
[Mh] Termos MeSH primário: Poluentes Ambientais/toxicidade
Imunomodulação/efeitos dos fármacos
Chumbo/toxicidade
Sistemas Neurossecretores/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Feminino
Seres Humanos
Masculino
Fatores Sexuais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Environmental Pollutants); 2P299V784P (Lead)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE


  4 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28911135
[Au] Autor:Arnoni-Bauer Y; Bick A; Raz N; Imbar T; Amos S; Agmon O; Marko L; Levin N; Weiss R
[Ad] Endereço:Department of Human Metabolism and Nutrition, Braun School of Public Health, Hebrew University, Jerusalem 91120, Israel.
[Ti] Título:Is It Me or My Hormones? Neuroendocrine Activation Profiles to Visual Food Stimuli Across the Menstrual Cycle.
[So] Source:J Clin Endocrinol Metab;102(9):3406-3414, 2017 Sep 01.
[Is] ISSN:1945-7197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context: Homeostatic energy balance is controlled via the hypothalamus, whereas regions controlling reward and cognitive decision-making are critical for hedonic eating. Eating varies across the menstrual cycle peaking at the midluteal phase. Objective: To test responses of females with regular cycles during midfollicular and midluteal phase and of users of monophasic oral contraception pills (OCPs) to visual food cues. Design: Participants performed a functional magnetic resonance imaging while exposed to visual food cues in four time points: fasting and fed conditions in midfollicular and midluteal phases. Patients: Twenty females with regular cycles and 12 on monophasic OCP, aged 18 to 35 years. Main Outcome Measures: Activity in homeostatic (hypothalamus), reward (amygdala, putamen and insula), frontal (anterior cingulate cortex, dorsolateral prefrontal cortex), and visual regions (calcarine and lateral occipital cortex). Setting: Tertiary hospital. Results: In females with regular cycles, brain regions associated with homeostasis but also the reward system, executive frontal areas, and afferent visual areas were activated to a greater degree during the luteal compared with the follicular phase. Within the visual areas, a dual effect of hormonal and prandial state was seen. In females on monophasic OCPs, characterized by a permanently elevated progesterone concentration, activity reminiscent of the luteal phase was found. Androgen, cortisol, testosterone, and insulin levels were significantly correlated with reward and visual region activation. Conclusions: Hormonal mechanisms affect the responses of women's homeostatic, emotional, and attentional brain regions to food cues. The relation of these findings to eating behavior throughout the cycle needs further investigation.
[Mh] Termos MeSH primário: Córtex Cerebral/diagnóstico por imagem
Comportamento Alimentar/fisiologia
Imagem por Ressonância Magnética/métodos
Ciclo Menstrual/fisiologia
Sistemas Neurossecretores/fisiologia
Estimulação Luminosa
[Mh] Termos MeSH secundário: Adolescente
Adulto
Tonsila do Cerebelo/fisiologia
Córtex Cerebral/fisiologia
Sinais (Psicologia)
Comportamento Alimentar/psicologia
Feminino
Fase Folicular/fisiologia
Seres Humanos
Hipotálamo/fisiologia
Fase Luteal/fisiologia
Ciclo Menstrual/psicologia
Amostragem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170916
[St] Status:MEDLINE
[do] DOI:10.1210/jc.2016-3921


  5 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28895797
[Au] Autor:Rosenfeld CS; Denslow ND; Orlando EF; Gutierrez-Villagomez JM; Trudeau VL
[Ad] Endereço:a Department of Biomedical Sciences , University of Missouri , Columbia , MO , USA.
[Ti] Título:Neuroendocrine disruption of organizational and activational hormone programming in poikilothermic vertebrates.
[So] Source:J Toxicol Environ Health B Crit Rev;20(5):276-304, 2017.
[Is] ISSN:1521-6950
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In vertebrates, sexual differentiation of the reproductive system and brain is tightly orchestrated by organizational and activational effects of endogenous hormones. In mammals and birds, the organizational period is typified by a surge of sex hormones during differentiation of specific neural circuits; whereas activational effects are dependent upon later increases in these same hormones at sexual maturation. Depending on the reproductive organ or brain region, initial programming events may be modulated by androgens or require conversion of androgens to estrogens. The prevailing notion based upon findings in mammalian models is that male brain is sculpted to undergo masculinization and defeminization. In absence of these responses, the female brain develops. While timing of organizational and activational events vary across taxa, there are shared features. Further, exposure of different animal models to environmental chemicals such as xenoestrogens such as bisphenol A-BPA and ethinylestradiol-EE2, gestagens, and thyroid hormone disruptors, broadly classified as neuroendocrine disrupting chemicals (NED), during these critical periods may result in similar alterations in brain structure, function, and consequently, behaviors. Organizational effects of neuroendocrine systems in mammals and birds appear to be permanent, whereas teleost fish neuroendocrine systems exhibit plasticity. While there are fewer NED studies in amphibians and reptiles, data suggest that NED disrupt normal organizational-activational effects of endogenous hormones, although it remains to be determined if these disturbances are reversible. The aim of this review is to examine how various environmental chemicals may interrupt normal organizational and activational events in poikilothermic vertebrates. By altering such processes, these chemicals may affect reproductive health of an animal and result in compromised populations and ecosystem-level effects.
[Mh] Termos MeSH primário: Disruptores Endócrinos/efeitos adversos
Hormônios Esteroides Gonadais/fisiologia
Vertebrados/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Anfíbios/embriologia
Anfíbios/crescimento & desenvolvimento
Anfíbios/fisiologia
Animais
Encéfalo/efeitos dos fármacos
Encéfalo/embriologia
Encéfalo/crescimento & desenvolvimento
Feminino
Peixes/embriologia
Peixes/crescimento & desenvolvimento
Peixes/fisiologia
Hormônios Esteroides Gonadais/antagonistas & inibidores
Gônadas/efeitos dos fármacos
Gônadas/embriologia
Gônadas/crescimento & desenvolvimento
Gônadas/fisiologia
Masculino
Sistemas Neurossecretores/efeitos dos fármacos
Sistemas Neurossecretores/embriologia
Sistemas Neurossecretores/crescimento & desenvolvimento
Neurotransmissores/antagonistas & inibidores
Neurotransmissores/fisiologia
Répteis/embriologia
Répteis/crescimento & desenvolvimento
Répteis/fisiologia
Processos de Determinação Sexual/efeitos dos fármacos
Processos de Determinação Sexual/fisiologia
Vertebrados/embriologia
Vertebrados/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Endocrine Disruptors); 0 (Gonadal Steroid Hormones); 0 (Neurotransmitter Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170913
[St] Status:MEDLINE
[do] DOI:10.1080/10937404.2017.1370083


  6 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28807896
[Au] Autor:Fu T; Towers M; Placzek MA
[Ad] Endereço:The Bateson Centre and Department of Biomedical Science, University of Sheffield, Sheffield S10 2TN, UK.
[Ti] Título: progenitors give rise to the chick hypothalamus by rostral and caudal growth and differentiation.
[So] Source:Development;144(18):3278-3288, 2017 09 15.
[Is] ISSN:1477-9129
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Classical descriptions of the hypothalamus divide it into three rostro-caudal domains but little is known about their embryonic origins. To investigate this, we performed targeted fate-mapping, molecular characterisation and cell cycle analyses in the embryonic chick. Presumptive hypothalamic cells derive from the rostral diencephalic ventral midline, lie above the prechordal mesendoderm and express progenitors undergo anisotropic growth: those displaced rostrally differentiate into anterior cells, then those displaced caudally differentiate into mammillary cells. A stable population of progenitors is retained within the tuberal domain; a subset of these gives rise to the tuberal infundibulum - the precursor of the posterior pituitary. Pharmacological approaches reveal that Shh signalling promotes the growth and differentiation of anterior progenitors, and also orchestrates the development of the infundibulum and Rathke's pouch - the precursor of the anterior pituitary. Together, our studies identify a hypothalamic progenitor population defined by and highlight a role for Shh signalling in the integrated development of the hypothalamus and pituitary.
[Mh] Termos MeSH primário: Padronização Corporal
Diferenciação Celular
Fator 10 de Crescimento de Fibroblastos/metabolismo
Hipotálamo/citologia
Hipotálamo/embriologia
Células-Tronco/citologia
[Mh] Termos MeSH secundário: Animais
Anisotropia
Proliferação Celular
Embrião de Galinha
Galinhas
Diencéfalo/embriologia
Endoderma/embriologia
Proteínas Hedgehog/metabolismo
Mesoderma/embriologia
Modelos Biológicos
Sistemas Neurossecretores/metabolismo
Transdução de Sinais
Somitos/embriologia
Somitos/metabolismo
Células-Tronco/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fibroblast Growth Factor 10); 0 (Hedgehog Proteins)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171126
[Lr] Data última revisão:
171126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170816
[St] Status:MEDLINE
[do] DOI:10.1242/dev.153379


  7 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28753616
[Au] Autor:Kalacheva NV; Eliseikina MG; Frolova LT; Dolmatov IY
[Ad] Endereço:A.V. Zhirmunsky Institute of Marine Biology, National Scientific Center of Marine Biology, Far Eastern Branch, Russian Academy of Sciences, Vladivostok, Russia.
[Ti] Título:Regeneration of the digestive system in the crinoid Himerometra robustipinna occurs by transdifferentiation of neurosecretory-like cells.
[So] Source:PLoS One;12(7):e0182001, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The structure and regeneration of the digestive system in the crinoid Himerometra robustipinna (Carpenter, 1881) were studied. The gut comprises a spiral tube forming radial lateral processes, which gives it a five-lobed shape. The digestive tube consists of three segments: esophagus, intestine, and rectum. The epithelia of these segments have different cell compositions. Regeneration of the gut after autotomy of the visceral mass progresses very rapidly. Within 6 h after autotomy, an aggregation consisting of amoebocytes, coelomic epithelial cells and juxtaligamental cells (neurosecretory neurons) forms on the inner surface of the skeletal calyx. At 12 h post-autotomy, transdifferentiation of the juxtaligamental cells starts. At 24 h post-autotomy these cells undergo a mesenchymal-epithelial-like transition, resulting in the formation of the luminal epithelium of the gut. Specialization of the intestinal epithelial cells begins on day 2 post-autotomy. At this stage animals acquire the mouth and anal opening. On day 4 post-autotomy the height of both the enterocytes and the visceral mass gradually increases. Proliferation does not play any noticeable role in gut regeneration. The immersion of animals in a 10-7 M solution of colchicine neither stopped formation of the lost structures nor caused accumulation of mitoses in tissues. Weakly EdU-labeled nuclei were observed in the gut only on day 2 post-autotomy and were not detected at later regeneration stages. Single mitotically dividing cells were recorded during the same period. It is concluded that juxtaligamental cells play a major role in gut regeneration in H. robustipinna. The main mechanisms of morphogenesis are cell migration and transdifferentiation.
[Mh] Termos MeSH primário: Transdiferenciação Celular
Equinodermos/citologia
Equinodermos/fisiologia
Trato Gastrointestinal/fisiologia
Sistemas Neurossecretores/citologia
Regeneração/fisiologia
[Mh] Termos MeSH secundário: Animais
Transdiferenciação Celular/efeitos dos fármacos
Colchicina/farmacologia
DNA/biossíntese
Equinodermos/efeitos dos fármacos
Epitélio/efeitos dos fármacos
Epitélio/ultraestrutura
Trato Gastrointestinal/efeitos dos fármacos
Trato Gastrointestinal/ultraestrutura
Imagem Tridimensional
Mitose/efeitos dos fármacos
Sistemas Neurossecretores/efeitos dos fármacos
Regeneração/efeitos dos fármacos
Soluções
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Solutions); 9007-49-2 (DNA); SML2Y3J35T (Colchicine)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170729
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182001


  8 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28709033
[Au] Autor:Egorov AI; Griffin SM; Converse RR; Styles JN; Sams EA; Wilson A; Jackson LE; Wade TJ
[Ad] Endereço:National Health and Environmental Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, NC, USA. Electronic address: egorov.andrey@epa.gov.
[Ti] Título:Vegetated land cover near residence is associated with reduced allostatic load and improved biomarkers of neuroendocrine, metabolic and immune functions.
[So] Source:Environ Res;158:508-521, 2017 10.
[Is] ISSN:1096-0953
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Greater exposure to urban green spaces has been linked to reduced risks of depression, cardiovascular disease, diabetes and premature death. Alleviation of chronic stress is a hypothesized pathway to improved health. Previous studies linked chronic stress with a biomarker-based composite measure of physiological dysregulation known as allostatic load. OBJECTIVE: This study's objective was to assess the relationship between vegetated land cover near residences and allostatic load. METHODS: This cross-sectional population-based study involved 206 adult residents of the Durham-Chapel Hill, North Carolina metropolitan area. Exposure was quantified using high-resolution metrics of trees and herbaceous vegetation within 500m of each residence derived from the U.S. Environmental Protection Agency's EnviroAtlas land cover dataset. Eighteen biomarkers of immune, neuroendocrine, and metabolic functions were measured in serum or saliva samples. Allostatic load was defined as a sum of potentially unhealthy biomarker values dichotomized at 10th or 90th percentile of sample distribution. Regression analysis was conducted using generalized additive models with two-dimensional spline smoothing function of geographic coordinates, weighted measures of vegetated land cover allowing decay of effects with distance, and geographic and demographic covariates. RESULTS: An inter-quartile range increase in distance-weighted vegetated land cover was associated with 37% (95% Confidence Limits 46%; 27%) reduced allostatic load; significantly reduced adjusted odds of having low level of norepinephrine, dopamine, and dehydroepiandrosterone, and high level of epinephrine, fibrinogen, vascular cell adhesion molecule-1, and interleukin-8 in serum, and α-amylase in saliva; and reduced odds of previously diagnosed depression. CONCLUSIONS: The observed effects of vegetated land cover on allostatic load and individual biomarkers are consistent with prevention of depression, cardiovascular disease and premature mortality.
[Mh] Termos MeSH primário: Alostase
Meio Ambiente
Distribuição Espacial da População
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Metabolismo Basal
Biomarcadores/sangue
Biomarcadores/metabolismo
Estudos Transversais
Feminino
Seres Humanos
Sistema Imunitário
Masculino
Meia-Idade
Sistemas Neurossecretores
North Carolina
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171120
[Lr] Data última revisão:
171120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170715
[St] Status:MEDLINE


  9 / 9143 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28664919
[Au] Autor:Hackett RA; Steptoe A
[Ad] Endereço:Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London WC1E 6BT, UK.
[Ti] Título:Type 2 diabetes mellitus and psychological stress - a modifiable risk factor.
[So] Source:Nat Rev Endocrinol;13(9):547-560, 2017 Sep.
[Is] ISSN:1759-5037
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Psychological stress is common in many physical illnesses and is increasingly recognized as a risk factor for disease onset and progression. An emerging body of literature suggests that stress has a role in the aetiology of type 2 diabetes mellitus (T2DM) both as a predictor of new onset T2DM and as a prognostic factor in people with existing T2DM. Here, we review the evidence linking T2DM and psychological stress. We highlight the physiological responses to stress that are probably related to T2DM, drawing on evidence from animal work, large epidemiological studies and human laboratory trials. We discuss population and clinical studies linking psychological and social stress factors with T2DM, and give an overview of intervention studies that have attempted to modify psychological or social factors to improve outcomes in people with T2DM.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/psicologia
Estresse Psicológico/complicações
[Mh] Termos MeSH secundário: Animais
Sistema Nervoso Autônomo
Diabetes Mellitus Tipo 2/epidemiologia
Diabetes Mellitus Tipo 2/terapia
Comportamentos Relacionados com a Saúde
Seres Humanos
Inflamação
Sistemas Neurossecretores
Prognóstico
Fatores de Risco
Estresse Psicológico/epidemiologia
Estresse Psicológico/terapia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170701
[St] Status:MEDLINE
[do] DOI:10.1038/nrendo.2017.64


  10 / 9143 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28621341
[Au] Autor:Chachlaki K; Garthwaite J; Prevot V
[Ad] Endereço:Inserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, UMR-S 1172, 1 place de Verdun, F-59000 Lille, France.
[Ti] Título:The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus.
[So] Source:Nat Rev Endocrinol;13(9):521-535, 2017 Sep.
[Is] ISSN:1759-5037
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The chemical signalling molecule nitric oxide (NO), which freely diffuses through aqueous and lipid environments, subserves an array of functions in the mammalian central nervous system, such as the regulation of synaptic plasticity, blood flow and neurohormone secretion. In this Review, we consider the cellular and molecular mechanisms by which NO evokes short-term and long-term changes in neuronal activity. We also highlight recent studies showing that discrete populations of neurons that synthesize NO in the hypothalamus constitute integrative systems that support life by relaying metabolic and gonadal signals to the neuroendocrine brain, and thus gate the onset of puberty and adult fertility. The putative involvement and therapeutic potential of NO in the pathophysiology of brain diseases, for which hormonal imbalances during postnatal development could be risk factors, is also discussed.
[Mh] Termos MeSH primário: Hipotálamo/fisiologia
Óxido Nítrico/fisiologia
[Mh] Termos MeSH secundário: Animais
Encéfalo/fisiologia
Sistema Nervoso Central/fisiologia
Feminino
Fertilidade/fisiologia
Regulação da Expressão Gênica
Gônadas
Seres Humanos
Sistema Hipotálamo-Hipofisário
Masculino
Plasticidade Neuronal
Neurônios/fisiologia
Sistemas Neurossecretores/fisiologia
Óxido Nítrico/biossíntese
Óxido Nítrico Sintase Tipo I/genética
Ovário/fisiologia
Puberdade/fisiologia
Reprodução/fisiologia
Maturidade Sexual
Transdução de Sinais/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type I)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170617
[St] Status:MEDLINE
[do] DOI:10.1038/nrendo.2017.69



página 1 de 915 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde