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  1 / 20144 MEDLINE  
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[PMID]:29431947
[Au] Autor:Lapko IV; Kiryakov VA; Pavlovskaya NA; Oshkoderov OA; Klimkina KV
[Ti] Título:[Choice of informative laboratory biomarkers for the early identification of changes in neurohumoral regulation and carbohydrate exchange in workers of the mining and mechanical engineering industry].
[So] Source:Gig Sanit;95(11):1061-5, 2016.
[Is] ISSN:0016-9900
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The diagnostic significance of hormones and integral indices of pituitary-adrenal, pituitary-thyroid and pituitary-gonadal system and carbohydrate metabolism (ACTH (corticotropin), aldosterone, cortisol, TSH (thyroid-stimulating hormone), free triiodothyronine (fT3), free thyroxine (fT4), luteinizing hormone (LH), follicle-stimulating hormone (FSH), total and free testosterone, insulin, integral pituitary-adrenal index (IPAI), the pituitary-thyroid index (PTI), indices of carbohydrate metabolism (Caro and HOMA-IR) was studied for the early diagnostics of disorders of neurohumoral regulation in workers of mining and mechanical engineering industries. The most informative indices, permitting to identify disorders of carbohydrate metabolism are established to be indices of insulin resistance (index Caro and index NOMA-IR) and the determination of insulin in serum. For the identification of changes in pituitary adrenal, pituitary-thyroid and pituitary-gonadal system in patients with vibration disease, sensory-neural hearing loss, comorbidity indexes IGNI, ITI, concentrations of LH and total testosterone are of the most diagnostically significance.
[Mh] Termos MeSH primário: Hormônio Adrenocorticotrópico/sangue
Hormônio Foliculoestimulante/sangue
Insulina/sangue
Doenças Profissionais
Tireotropina/sangue
[Mh] Termos MeSH secundário: Adulto
Biomarcadores/sangue
Metabolismo dos Carboidratos/fisiologia
Indústrias Extrativas e de Processamento/métodos
Indústrias Extrativas e de Processamento/normas
Feminino
Seres Humanos
Sistema Hipotálamo-Hipofisário/metabolismo
Masculino
Meia-Idade
Doenças Profissionais/sangue
Doenças Profissionais/diagnóstico
Doenças Profissionais/etiologia
Doenças Profissionais/prevenção & controle
Saúde do Trabalhador
Sistema Hipófise-Suprarrenal/metabolismo
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Insulin); 9002-60-2 (Adrenocorticotropic Hormone); 9002-68-0 (Follicle Stimulating Hormone); 9002-71-5 (Thyrotropin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180213
[St] Status:MEDLINE


  2 / 20144 MEDLINE  
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[PMID]:29408859
[Au] Autor:Liu H; Wang J; Li L; Han C; He H; Xu H
[Ad] Endereço:Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, P.R. China.
[Ti] Título:Transcriptome analysis revealed the possible regulatory pathways initiating female geese broodiness within the hypothalamic-pituitary-gonadal axis.
[So] Source:PLoS One;13(2):e0191213, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Geese have the strongest tendency toward broodiness among all poultry. The mechanisms initiating broodiness within the goose hypothalamic-pituitary-gonadal axis (HPGA) are still unclear. Here, we reported the transcriptome differences between laying and initial nesting within the HPGA tissues of geese. We constructed a unigene database based on HPGA tissues and identified 128,148 unigenes, 100% of which have been annotated. By using Digital Gene Expression (DGE) sequencing, we screened 19, 110, 289, and 211 differentially expressed genes (DEGs) in the hypothalamus, pituitary gland, stroma ovarii, and follicles, respectively, between laying and nesting geese. Expression changes of hypocretin (HCRT) and pro-opiomelanocortin (POMC) in the hypothalamus of nesting geese may cause appetite reduction, which is possibly the first step and a prerequisite to initiate broodiness. In addition to prolactin (PRL), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), genes including oxytocin-neurophysin (OXT), chordin-like protein 1 (CHRDL1) and growth hormone (GH), expressed in the pituitary gland, are new candidate molecules that may be involved in broodiness in geese. Heme oxygenase 1 (HMOX1) in the pituitary gland, the proto-oncogene c-Fos (FOS), heat shock protein 90-alpha (HSP90AA), and cyclin-dependent kinase 1 (CDK1) in the ovary that may consolidate and transduce signals regulating the HPGA during broodiness in geese.
[Mh] Termos MeSH primário: Gônadas/fisiologia
Sistema Hipotálamo-Hipofisário/fisiologia
Transcriptoma
[Mh] Termos MeSH secundário: Animais
Feminino
Gansos
Expressão Gênica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0191213


  3 / 20144 MEDLINE  
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[PMID]:27776734
[Au] Autor:Morrison KE; Epperson CN; Sammel MD; Ewing G; Podcasy JS; Hantsoo L; Kim DR; Bale TL
[Ad] Endereço:Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; Penn PROMOTES Research on Sex and Gender in Health, University of Pennsylvania, Philadelphia, Pennsylvania.
[Ti] Título:Preadolescent Adversity Programs a Disrupted Maternal Stress Reactivity in Humans and Mice.
[So] Source:Biol Psychiatry;81(8):693-701, 2017 04 15.
[Is] ISSN:1873-2402
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Adverse childhood experiences (ACEs) are one of the greatest predictors of affective disorders for women. Periods of dynamic hormonal flux, including pregnancy, exacerbate the risk for affective disturbance and promote hypothalamic-pituitary-adrenal (HPA) axis dysregulation, a key feature of affective disorders. Little is understood as to how stress experienced in late childhood, defined as preadolescence, alters the programming unique to this period of brain maturation and its interaction with the hormonal changes of pregnancy and postpartum. METHODS: Preadolescent female mice were exposed to chronic stress and examined for changes in their HPA axis during pregnancy and postpartum, including assessment of maternal-specific stress responsiveness and transcriptomics of the paraventricular nucleus of the hypothalamus. Translationally, pregnant women with low or high ACEs were examined for their maternal stress responsiveness. RESULTS: As predicted, preadolescent stress in mice resulted in a significant blunting of the corticosterone response during pregnancy. Transcriptomic analysis of the paraventricular nucleus revealed widespread changes in expression of immediate early genes and their targets, supporting the likely involvement of an upstream epigenetic mechanism. Critically, in our human studies, the high ACE women showed a significant blunting of the HPA response. CONCLUSIONS: This unique mouse model recapitulates a clinical outcome of a hyporesponsive HPA stress axis, an important feature of affective disorders, during a dynamic hormonal period, and suggests involvement of transcriptional regulation in the hypothalamus. These studies identify a novel mouse model of female ACEs that can be used to examine how additional life adversity may provoke disease risk or resilience.
[Mh] Termos MeSH primário: Adultos Sobreviventes de Eventos Adversos na Infância
Sistema Hipotálamo-Hipofisário/fisiopatologia
Comportamento Materno/fisiologia
Sistema Hipófise-Suprarrenal/fisiopatologia
Estresse Psicológico/fisiopatologia
[Mh] Termos MeSH secundário: Adulto
Animais
Corticosterona/metabolismo
Feminino
Perfilação da Expressão Gênica
Seres Humanos
Sistema Hipotálamo-Hipofisário/metabolismo
Camundongos
Camundongos Endogâmicos C57BL
Núcleo Hipotalâmico Paraventricular/metabolismo
Sistema Hipófise-Suprarrenal/metabolismo
Período Pós-Parto
Gravidez
Estresse Psicológico/metabolismo
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; RESEARCH SUPPORT, N.I.H., EXTRAMURAL
[Nm] Nome de substância:
W980KJ009P (Corticosterone)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


  4 / 20144 MEDLINE  
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[PMID]:28463242
[Au] Autor:Short AK; Yeshurun S; Powell R; Perreau VM; Fox A; Kim JH; Pang TY; Hannan AJ
[Ad] Endereço:Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, VIC, Australia.
[Ti] Título:Exercise alters mouse sperm small noncoding RNAs and induces a transgenerational modification of male offspring conditioned fear and anxiety.
[So] Source:Transl Psychiatry;7(5):e1114, 2017 May 02.
[Is] ISSN:2158-3188
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is growing evidence that the preconceptual lifestyle and other environmental exposures of a father can significantly alter the physiological and behavioral phenotypes of their children. We and others have shown that paternal preconception stress, regardless of whether the stress was experienced during early-life or adulthood, results in offspring with altered anxiety and depression-related behaviors, attributed to hypothalamic-pituitary-adrenal axis dysregulation. The transgenerational response to paternal preconceptual stress is believed to be mediated by sperm-borne small noncoding RNAs, specifically microRNAs. As physical activity confers physical and mental health benefits for the individual, we used a model of voluntary wheel-running and investigated the transgenerational response to paternal exercise. We found that male offspring of runners had suppressed reinstatement of juvenile fear memory, and reduced anxiety in the light-dark apparatus during adulthood. No changes in these affective behaviors were observed in female offspring. We were surprised to find that running had a limited impact on sperm-borne microRNAs. The levels of three unique microRNAs (miR-19b, miR-455 and miR-133a) were found to be altered in the sperm of runners. In addition, we discovered that the levels of two species of tRNA-derived RNAs (tDRs)-tRNA-Gly and tRNA-Pro-were also altered by running. Taken together, we believe this is the first evidence that paternal exercise is associated with an anxiolytic behavioral phenotype of male offspring and altered levels of small noncoding RNAs in sperm. These small noncoding RNAs are known to have an impact on post-transcriptional gene regulation and can thus change the developmental trajectory of offspring brains and associated affective behaviors.
[Mh] Termos MeSH primário: Ansiedade/genética
Medo/psicologia
Transmissão Vertical de Doença Infecciosa/veterinária
MicroRNAs/genética
Condicionamento Físico Animal/efeitos adversos
Espermatozoides/metabolismo
[Mh] Termos MeSH secundário: Animais
Ansiedade/psicologia
Depressão/genética
Depressão/psicologia
Exposição Ambiental/efeitos adversos
Feminino
Regulação da Expressão Gênica
Sistema Hipotálamo-Hipofisário/fisiopatologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Fenótipo
Sistema Hipófise-Suprarrenal/fisiopatologia
Pequeno RNA não Traduzido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MicroRNAs); 0 (RNA, Small Untranslated)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1038/tp.2017.82


  5 / 20144 MEDLINE  
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[PMID]:29381014
[Au] Autor:Fefelova YA; Sergeeva EY; Novikova LV; Klimina GM
[Ti] Título:[The influence of diets on metabolic processes associated with sirtuin1].
[So] Source:Vopr Pitan;85(4):5-13, 2016.
[Is] ISSN:0042-8833
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Over the last decade the investigations of the sirtuin protein family have become one of the research priorities. It is connected with the fact that sirtuins play an important role as regulators of cell homeostasis in mammals. Sirtuins can regulate metabolism by the influence on some processes in CNS, liver, pancreas, musles, adipose tissue. It emphasizes the importance of sirtuins in the development of heart diseases, cancer, metabolic syndrome, neurodegenerative and some other diseases. Stress factors in particular calorie restriction alter sirtuins activity, that leads to some significant alterations of intracellular processes: activation of reparation processes, increase of DNA stability, elevation of metabolic rate and the lifespan of cells. In this review, we focus our attention on the influence of calorie restriction on metabolic alterations associated with regulatory role of sirtuin1. Sirtuin1 plays a leading role in regulation of cell homeostasis by controlling some important processes, such as gene transcription, cell differentiation, stress reaction, inflammation, apoptosis, circadian rhythms and life expectancy. We touch briefly on the connection between some alterations of diet and the development of stress reaction and inflammation. In the review the metabolic alterations in liver, pancreas, adipose tissue and central regulatory role of sirtuinl in hypothalamic-pituitary-adrenal axis connected with calorie restriction are discussed. Sirtuin1 can be a messenger of some effects of calorie restriction on organism, acting as a cell energy sensor. Thus, sirtuinl plays a central role in control and modulation of metabolic processes under alterations of diet. Having been one of the most important regulator of homeostasis, sirtuinl can be a key element of regulation. The influence on this element gives the opportunities of regulation of metabolism, calorie restriction effects and creation of new pathogenical methods of treatment.
[Mh] Termos MeSH primário: Dieta
Sirtuína 1/metabolismo
[Mh] Termos MeSH secundário: Animais
Apoptose
Diferenciação Celular
Ritmo Circadiano
Reparo do DNA
Instabilidade Genômica
Seres Humanos
Sistema Hipotálamo-Hipofisário/metabolismo
Inflamação
Longevidade
Especificidade de Órgãos
Sistema Hipófise-Suprarrenal/metabolismo
Sirtuína 1/genética
Estresse Fisiológico
Transcrição Genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
EC 3.5.1.- (SIRT1 protein, human); EC 3.5.1.- (Sirtuin 1)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180131
[St] Status:MEDLINE


  6 / 20144 MEDLINE  
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[PMID]:29283234
[Au] Autor:Burenkova OV; Aleksandrova AA; Zarayskaya IY
[Ti] Título:Epigenetic Mechanisms of Long-Term Effects of Mother-Infant Relationship on Physiology and Behavior of the Offspring.
[So] Source:Usp Fiziol Nauk;47(4):43-56, 2016 Oct-Dec.
[Is] ISSN:0301-1798
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:The quality of mother-infant relationship in the early postnatal period influences the neurophysiology and behavior of adult animals via epigenetic mechanisms. The most studied target of long-term effects of early life events on physiology and behavior is hypothalamic-pituitary-adrenal axis, in particular, epigenetic programming of glucocorticoid receptor gene expression. Inhibition of histone deacetylases is a tool for epigenetic modulation of nervous system plasticity. Using this approach, it was demonstrated that epigenetic mechanisms play an important role in physiological and behavioral modifications. It is also promising tool for reversing the negative effects of disturbances in the mother-infant relationship early in life. To date, however, the use of histone deacetylase inhibitors is widespread in adult animals, while studies in the early postnatal period are still scarce despite their relevance.
[Mh] Termos MeSH primário: Epigênese Genética
Histona Desacetilases/metabolismo
Sistema Hipotálamo-Hipofisário/fisiologia
Relações Mãe-Filho
Sistema Hipófise-Suprarrenal/fisiologia
Receptores de Glucocorticoides/metabolismo
[Mh] Termos MeSH secundário: Acetilação/efeitos dos fármacos
Animais
Metilação de DNA/efeitos dos fármacos
Feminino
Inibidores de Histona Desacetilases/farmacologia
Histona Desacetilases/genética
Histonas/genética
Histonas/metabolismo
Seres Humanos
Sistema Hipotálamo-Hipofisário/efeitos dos fármacos
Lactente
Plasticidade Neuronal
Sistema Hipófise-Suprarrenal/efeitos dos fármacos
Receptores de Glucocorticoides/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Histone Deacetylase Inhibitors); 0 (Histones); 0 (Receptors, Glucocorticoid); EC 3.5.1.98 (Histone Deacetylases)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171229
[St] Status:MEDLINE


  7 / 20144 MEDLINE  
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[PMID]:29267376
[Au] Autor:Lundberg S; Abelson KSP; Nylander I; Roman E
[Ad] Endereço:Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
[Ti] Título:Few long-term consequences after prolonged maternal separation in female Wistar rats.
[So] Source:PLoS One;12(12):e0190042, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Environmental factors during the early-life period are known to have long-term consequences for the adult phenotype. An intimate interplay between genes and environment shape the individual and may affect vulnerability for psychopathology in a sex-dependent manner. A rodent maternal separation model was here used to study the long-term effects of different early-life rearing conditions on adult behavior, HPA axis activity and long-term voluntary alcohol intake in female rats. Litters were subjected to 15 min (MS15) or 360 min (MS360) of daily maternal separation during postnatal day 1-21. In adulthood, the behavioral profiles were investigated using the multivariate concentric square field™ (MCSF) test or examined for HPA axis reactivity by cat-odor exposure with subsequent characterization of voluntary alcohol intake and associated changes in HPA axis activity. Adult female MS360 offspring showed mostly no, or only minor, effects on behavior, HPA axis reactivity and long-term alcohol intake relative to MS15. Instead, more pronounced effects were found dependent on changes in the natural hormonal cycle or by the choice of animal supplier. However, changes were revealed in corticosterone load after long-term alcohol access, as females subjected to MS360 had higher concentrations of fecal corticosterone. The present findings are in line with and expand on previous studies on the long-term effects of maternal separation in female rats with regard to behavior, HPA axis activity and voluntary alcohol intake. It can also be a window into further studies detailing how early-life experiences interact with other risk and protective factors to impact the adult phenotype and how possible sex differences play a role.
[Mh] Termos MeSH primário: Privação Materna
[Mh] Termos MeSH secundário: Glândulas Suprarrenais/fisiologia
Animais
Comportamento Animal
Feminino
Sistema Hipotálamo-Hipofisário
Masculino
Gravidez
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171222
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190042


  8 / 20144 MEDLINE  
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[PMID]:28743461
[Au] Autor:Liu XH; Wang ZJ; Jin L; Huang J; Pu DY; Wang DS; Zhang YG
[Ad] Endereço:Key Laboratory of Freshwater Fish Reproduction and Development (Ministry of Education), Key Laboratory of Aquatic Science of Chongqing, Southwest University School of Life Sciences, Chongqing 400715, China.
[Ti] Título:Effects of subchronic exposure to waterborne cadmium on H-P-I axis hormones and related genes in rare minnows (Gobiocypris rarus).
[So] Source:Comp Biochem Physiol C Toxicol Pharmacol;202:1-11, 2017 Nov.
[Is] ISSN:1532-0456
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The H (hypothalamic)-P (pituitary)-I (interrenal) axis is critical in the stress response and other activities of fish. To further investigate cadmium (Cd) toxicity on the H-P-I axis and to identify its potential regulatory genes in fish, the adult female rare minnows (Gobiocypris rarus) were exposed to subchronic (5weeks) levels of waterborne Cd in the present study. This kind of treatment caused dose-dependent decline in fish growth, with significance in the high dose group (100µg/L). Correspondingly, low dose (5-50µg/L) waterborne Cd disrupted the endocrine system of H-P-I axis just at the secretion level, while high dose Cd disrupted both the secretion and synthesis of cortisol and its downstream signals in rare minnows, revealed by the significantly upregulation and positive correlation of corticosteroidogenic genes including MC2R, StAR, CYP11A1, and CYP11B1 in the kidney (including the interrenal tissue) (P<0.05), and the significant alteration of Glcci1, Hsp90AA and Hsp90AB in the hepatopancreas, gill and intestine as well (P<0.05). The expression of Glcci1 was significantly decreased in hepatopancreas, gill and intestine of tested fish following treatment, and its positive correlation with GR (Glucocorticoid receptor) suggested its potential regulation on the cortisol and/or H-P-I axis in fish. The expression of FKBP5 in the intestine was positively and significantly correlated with that of Hsp90AA (P<0.05), and the Hsp90AB transcript in the hepatopancreas was positively correlated with that of Hsp90AA (P<0.05), which indicated that Hsp90AA and Hsp90AB were more likely to serve as cofactors of GR and FKBP5 in response to Cd exposure.
[Mh] Termos MeSH primário: Cloreto de Cádmio/toxicidade
Cyprinidae/fisiologia
Sistema Hipotálamo-Hipofisário/efeitos dos fármacos
Glândula Inter-Renal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Hormônio Adrenocorticotrópico/genética
Hormônio Adrenocorticotrópico/metabolismo
Animais
Cloreto de Cádmio/administração & dosagem
Hormônio Liberador da Corticotropina/genética
Hormônio Liberador da Corticotropina/metabolismo
Esquema de Medicação
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Hidrocortisona/genética
Hidrocortisona/metabolismo
Sistema Hipotálamo-Hipofisário/fisiologia
Glândula Inter-Renal/fisiologia
Hormônios Estimuladores de Melanócitos/genética
Hormônios Estimuladores de Melanócitos/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Proteínas de Ligação a Tacrolimo/genética
Proteínas de Ligação a Tacrolimo/metabolismo
Poluentes Químicos da Água/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (RNA, Messenger); 0 (Water Pollutants, Chemical); 9002-60-2 (Adrenocorticotropic Hormone); 9002-79-3 (Melanocyte-Stimulating Hormones); 9015-71-8 (Corticotropin-Releasing Hormone); EC 5.2.1.- (Tacrolimus Binding Proteins); J6K4F9V3BA (Cadmium Chloride); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180109
[Lr] Data última revisão:
180109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE


  9 / 20144 MEDLINE  
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[PMID]:29180003
[Au] Autor:Zhang Q; Chen Z; Chen S; Yu T; Wang J; Wang W; Deng H
[Ad] Endereço:Key Laboratory of Child Development and Learning Science (Southeast University), Ministry of Education, Institute of Child Development and Education, Southeast University, Nanjing 210096, China; School of early childhood education, Jiangsu Second Normal University, Nanjing 210012, China.
[Ti] Título:Correlations of hair level with salivary level in cortisol and cortisone.
[So] Source:Life Sci;193:57-63, 2018 Jan 15.
[Is] ISSN:1879-0631
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:AIMS: Contrary findings exist on the consistency between hair cortisol and salivary cortisol in assessing the basal activity of the hypothalamic-pituitary-adrenal (HPA) axis. The mismatches in temporal characteristic and the indices of hair and salivary cortisol might be potential reasons for the inconsistency. The aim of this study was to investigate the consistency between hair and salivary levels in cortisol and cortisone by directly examining the correlation between hair level and salivary level with different temporal characteristics (acute, short-term and long-term levels) and reflecting different HPA functions (basal level and reactivity level) in the well-matched time span. MAIN METHODS: A longitudinal design within a five-week period was conducted in a sample of 44 healthy female college students (mean age: 18.8yrs.; age range: 18-22yrs) of Han nationality with the exclusion criteria, such as use of oral contraceptives or glucocorticoids and bleached hairs, etc. Four saliva samples (awakening, awakening+30min, awakening+4h and awakening+9h) were collected from an identical participant on three separate days with an interval of one week and 1-cm hair segment nearest to the scalp was collected two weeks later after completing saliva collection. Cortisol and cortisone in saliva and hair were simultaneously measured with high performance liquid chromatography tandem mass spectrometry. KEY FINDINGS: There were significantly moderate correlations in cortisol and cortisone between hair level and three-day average of single-day salivary level, but low to moderate correlations between hair level and single-point and single-day salivary level. Hair cortisol and cortisone were unrelated to single-day level and three-day average of diurnal slope and cortisol awakening response of salivary cortisol and cortisone, respectively. SIGNIFICANCE: The considerable consistency between hair level and long-term salivary level in cortisol and cortisone implies that cortisol and cortisone in hair are valid biomarkers of cumulative exposure of cortisol and cortisone to retrospectively reflect long-term basal activity of the HPA system.
[Mh] Termos MeSH primário: Cortisona/análise
Hidrocortisona/análise
[Mh] Termos MeSH secundário: Adolescente
China
Cromatografia Líquida de Alta Pressão
Ritmo Circadiano/fisiologia
Cortisona/química
Grupos Étnicos
Feminino
Cabelo/química
Seres Humanos
Hidrocortisona/química
Sistema Hipotálamo-Hipofisário
Estudos Longitudinais
Sistema Hipófise-Suprarrenal
Saliva/química
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
V27W9254FZ (Cortisone); WI4X0X7BPJ (Hydrocortisone)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171129
[St] Status:MEDLINE


  10 / 20144 MEDLINE  
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[PMID]:29211774
[Au] Autor:Robertson BA; Rathbone L; Cirillo G; D'Eath RB; Bateson M; Boswell T; Wilson PW; Dunn IC; Smulders TV
[Ad] Endereço:Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.
[Ti] Título:Food restriction reduces neurogenesis in the avian hippocampal formation.
[So] Source:PLoS One;12(12):e0189158, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The mammalian hippocampus is particularly vulnerable to chronic stress. Adult neurogenesis in the dentate gyrus is suppressed by chronic stress and by administration of glucocorticoid hormones. Post-natal and adult neurogenesis are present in the avian hippocampal formation as well, but much less is known about its sensitivity to chronic stressors. In this study, we investigate this question in a commercial bird model: the broiler breeder chicken. Commercial broiler breeders are food restricted during development to manipulate their growth curve and to avoid negative health outcomes, including obesity and poor reproductive performance. Beyond knowing that these chickens are healthier than fully-fed birds and that they have a high motivation to eat, little is known about how food restriction impacts the animals' physiology. Chickens were kept on a commercial food-restricted diet during the first 12 weeks of life, or released from this restriction by feeding them ad libitum from weeks 7-12 of life. To test the hypothesis that chronic food restriction decreases the production of new neurons (neurogenesis) in the hippocampal formation, the cell proliferation marker bromodeoxyuridine was injected one week prior to tissue collection. Corticosterone levels in blood plasma were elevated during food restriction, even though molecular markers of hypothalamic-pituitary-adrenal axis activation did not differ between the treatments. The density of new hippocampal neurons was significantly reduced in the food-restricted condition, as compared to chickens fed ad libitum, similar to findings in rats at a similar developmental stage. Food restriction did not affect hippocampal volume or the total number of neurons. These findings indicate that in birds, like in mammals, reduction in hippocampal neurogenesis is associated with chronically elevated corticosterone levels, and therefore potentially with chronic stress in general. This finding is consistent with the hypothesis that the response to stressors in the avian hippocampal formation is homologous to that of the mammalian hippocampus.
[Mh] Termos MeSH primário: Ingestão de Energia
Hipocampo/crescimento & desenvolvimento
Neurogênese
[Mh] Termos MeSH secundário: Glândulas Suprarrenais/fisiologia
Animais
Galinhas
Corticosterona/sangue
Feminino
Sistema Hipotálamo-Hipofisário
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
W980KJ009P (Corticosterone)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171207
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0189158



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