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[PMID]:29309426
[Au] Autor:McDonald JS; McDonald RJ; Ekins JB; Tin AS; Costes S; Hudson TM; Schroeder DJ; Kallmes K; Kaufmann SH; Young PM; Lu A; Kadirvel R; Kallmes DF
[Ad] Endereço:Department of Radiology, College of Medicine, Mayo Clinic, Rochester, MN, United States of America.
[Ti] Título:Gadolinium-enhanced cardiac MR exams of human subjects are associated with significant increases in the DNA repair marker 53BP1, but not the damage marker γH2AX.
[So] Source:PLoS One;13(1):e0190890, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Magnetic resonance imaging is considered low risk, yet recent studies have raised a concern of potential damage to DNA in peripheral blood leukocytes. This prospective Institutional Review Board-approved study examined potential double-strand DNA damage by analyzing changes in the DNA damage and repair markers γH2AX and 53BP1 in patients who underwent a 1.5 T gadolinium-enhanced cardiac magnetic resonance (MR) exam. Sixty patients were enrolled (median age 55 years, 39 males). Patients with history of malignancy or who were receiving chemotherapy, radiation therapy, or steroids were excluded. MR sequence data were recorded and blood samples obtained immediately before and after MR exposure. An automated immunofluorescence assay quantified γH2AX or 53BP1 foci number in isolated peripheral blood mononuclear cells. Changes in foci number were analyzed using the Wilcoxon signed-rank test. Clinical and MR procedural characteristics were compared between patients who had a >10% increase in γH2AX or 53BP1 foci numbers and patients who did not. The number of γH2AX foci did not significantly change following cardiac MR (median foci per cell pre-MR = 0.11, post-MR = 0.11, p = .90), but the number of 53BP1 foci significantly increased following MR (median foci per cell pre-MR = 0.46, post-MR = 0.54, p = .0140). Clinical and MR characteristics did not differ significantly between patients who had at least a 10% increase in foci per cell and those who did not. We conclude that MR exposure leads to a small (median 25%) increase in 53BP1 foci, however the clinical relevance of this increase is unknown and may be attributable to normal variation instead of MR exposure.
[Mh] Termos MeSH primário: Biomarcadores/metabolismo
Dano ao DNA
Reparo do DNA
Gadolínio/administração & dosagem
Coração/diagnóstico por imagem
Histonas/metabolismo
Imagem por Ressonância Magnética/métodos
Proteína 1 de Ligação à Proteína Supressora de Tumor p53/metabolismo
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (H2AFX protein, human); 0 (Histones); 0 (TP53BP1 protein, human); 0 (Tumor Suppressor p53-Binding Protein 1); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180109
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190890


  2 / 115102 MEDLINE  
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[PMID]:29231013
[Au] Autor:Qian H; Shao Y; Li ZD; Zou DH; Qin ZQ; Wan L; Chen YJ
[Ad] Endereço:Department of Forensic Medicine, Medical College of Soochow University, Suzhou 215123, China.
[Ti] Título:[Diagnostic Value of Postmortem CT Angiography in Coronary Atherosclerosis].
[So] Source:Fa Yi Xue Za Zhi;33(2):109-113, 2017 Apr.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To explore the application value of postmortem computed tomography (CT) angiography on diagnosis of coronary atherosclerotic stenosis degree. METHODS: Based on the previous experimental results, the postmortem CT angiography device of human isolated heart was improved. Different coronary atherosclerotic stenosis degree of sudden death cases was selected. Before the cardiac anatomy, hearts were removed out completely and CT angiography was performed immediately. The CT angiography results were compared with histopathological findings. Meanwhile, the advantages and disadvantages of the angiography device before and after improvement were compared. RESULTS: The improved angiography device of isolated heart could get better imaging results. The postmortem CT angiography results had high consistency with the histopathological findings on diagnosis of coronary atherosclerotic stenosis degree. And the coronary artery lesions could be revealed more objectively and vividly by 3D reconstruction technology. However, CT angiography could only be used to examine the pathological changes of blood vessels, which might have some limitations on the diagnosis of cause of death. CONCLUSIONS: Postmortem CT angiography can be used as an additional method for the conventional autopsy in the cases of coronary atherosclerosis.
[Mh] Termos MeSH primário: Angiografia por Tomografia Computadorizada/métodos
Doença da Artéria Coronariana/diagnóstico por imagem
[Mh] Termos MeSH secundário: Autopsia
Angiografia Coronária
Estenose Coronária
Coração
Seres Humanos
Meia-Idade
Valor Preditivo dos Testes
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171213
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2017.02.001


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[PMID]:29204999
[Au] Autor:Wu YB; Guo HJ; Chen WJ; Li QJ
[Ad] Endereço:Institute of Criminal Science Technology, Shijiazhuang Public Security Bureau, Shijiazhuang 050021,China.
[Ti] Título:[Coronary Angiography in Isolated Hearts and Its Forensic Application].
[So] Source:Fa Yi Xue Za Zhi;32(5):329-331, 2016 Oct.
[Is] ISSN:1004-5619
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVES: To check the isolated heart by coronary angiography to discover the location, nature and degree of the coronary artery lesions more accurately and increase the comprehensive evaluation ability of cardiovascular disease. METHODS: Ten fresh isolated hearts with different causes of death were extracted and injected with barium sulphate as contrast substance by ring injector, then developed under Xper FD20 angiography equipment. The obtained pictures and image data were handled by three-dimensional angiography images with the software attached to the angiography equipment. The coronary artery tissues were HE stained and observed by microscope. The HE staining results were compared with the angiographic results. RESULTS: The imaging data obtained from the 10 cases for examination showed 8 cases without coronary artery stenosis and 2 cases with â…¢, â…£ coronary artery stenosis, which were consistent with HE staining results of coronary artery organization and the both results were confirmed. CONCLUSIONS: Isolated coronary angiography has an unique advantage for accurate grading of classification of coronary artery stenosis, examination of vascular malformation and tiny lesions, which can provide reference for the localization of small lesions and basis during the autopsy for identification conclusion.
[Mh] Termos MeSH primário: Angiografia Coronária
Estenose Coronária/diagnóstico por imagem
Coração/diagnóstico por imagem
[Mh] Termos MeSH secundário: Autopsia
Vasos Coronários/diagnóstico por imagem
Vasos Coronários/patologia
Seres Humanos
Imagem Tridimensional
Técnicas In Vitro
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171206
[St] Status:MEDLINE
[do] DOI:10.3969/j.issn.1004-5619.2016.05.003


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[PMID]:28453703
[Au] Autor:Guberina M; Eberhardt W; Stuschke M; Gauler T; Heinzelmann F; Cheufou D; Kimmich M; Friedel G; Schmidberger H; Darwiche K; Jendrossek V; Schuler M; Stamatis G; Pöttgen C
[Ad] Endereço:Department of Radiotherapy, University of Duisburg-Essen, University Hospital Essen, Essen.
[Ti] Título:Heart dose exposure as prognostic marker after radiotherapy for resectable stage IIIA/B non-small-cell lung cancer: secondary analysis of a randomized trial.
[So] Source:Ann Oncol;28(5):1084-1089, 2017 05 01.
[Is] ISSN:1569-8041
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background: Heart exposure to ionizing irradiation can cause ischaemic heart disease. The partial heart volume receiving ≥5 Gy (heartV5) was supposed to be an independent prognostic factor for survival after radiochemotherapy for locally advanced non-small-cell lung cancer (NSCLC). But validation of the latter hypothesis is needed under the concurrent risks of lung cancer patients. Patients and methods: The ESPATUE phase III trial recruited patients with potentially operable IIIA(N2)/selected IIIB NSCLC between 01/2004 and 01/2013. Cisplatin/paclitaxel induction chemotherapy was given followed by neoadjuvant radiochemotherapy (RT/CT) to 45 Gy (1.5 Gy bid/concurrent cisplatin/vinorelbine). Operable patients were randomized to definitive RT/CT(arm A) or surgery (arm B) and therefore were treated at two different total dose levels of radiotherapy. HeartV5 and mean heart dose (MHD) were obtained from the 3D radiotherapy plans, the prognostic value was analysed using multivariable proportional hazard analysis. Results: A total of 161 patients were randomized in ESPATUE, heartV5 and MHD were obtained from the 3D radiotherapy plans for 155 of these [male/female:105/50, median age 58 (33-74) years, stage IIIA/IIIB: 54/101]. Power analysis revealed a power of 80% of this dataset to detect a prognostic value of heartV5 of the size found in RTOG 0617. Multivariable analysis did not identify heartV5 as an independent prognostic factor for survival adjusting for tumour and clinical characteristics with [hazard ratio 1.005 (0.995-1.015), P = 0.30] or without lower lobe tumour location [hazard ratio 0.999 (0.986-1.012), P = 0.83]. There was no influence of heartV5 on death without tumour progression. Tumour progression, and pneumonia were the leading causes of death representing 65% and 14% of the observed deaths. Conclusions: HeartV5 could not be validated as an independent prognostic factor for survival after neoadjuvant or definitive conformal radiochemotherapy. Tumour progression was the predominant cause of death. Register No: Z5 - 22461/2 - 2002-017 (German Federal Office for Radiation Protection).
[Mh] Termos MeSH primário: Carcinoma Pulmonar de Células não Pequenas/terapia
Neoplasias Pulmonares/terapia
[Mh] Termos MeSH secundário: Adulto
Idoso
Carcinoma Pulmonar de Células não Pequenas/mortalidade
Carcinoma Pulmonar de Células não Pequenas/patologia
Quimiorradioterapia/efeitos adversos
Relação Dose-Resposta à Radiação
Feminino
Coração/efeitos da radiação
Seres Humanos
Neoplasias Pulmonares/mortalidade
Neoplasias Pulmonares/patologia
Masculino
Meia-Idade
Miocárdio/patologia
Estadiamento de Neoplasias
Prognóstico
Modelos de Riscos Proporcionais
Lesões por Radiação/diagnóstico
Lesões por Radiação/etiologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1093/annonc/mdx069


  5 / 115102 MEDLINE  
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[PMID]:29237522
[Au] Autor:Yi LF; Wen HX; Qiu M; Cao XX
[Ad] Endereço:Department of Electrocardiogram, Wuhan Children's Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430016, China. 380947312@qq.com.
[Ti] Título:[An analysis of cardiac autonomic nerve function in girls with idiopathic central precocious puberty].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1239-1242, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the cardiac autonomic nerve function in girls with idiopathic central precocious puberty (ICPP). METHODS: A total of 66 girls with ICPP were enrolled, among whom 36 were obese and 30 were not obese. A total of 68 age-matched healthy girls (normal controls) and 51 girls with simple obesity were enrolled as controls. All the subjects underwent 24-hour ambulatory electrocardiography, and deceleration capacity of heart rate (DC), acceleration capacity of heart rate (AC), and heart rate variability (HRV), and body mass index (BMI) were compared between groups. RESULTS: Compared with the normal control group, the ICPP group had significantly lower DC, standard deviation of normal-to-normal R-R intervals (SDNN), standard deviation of the average normal-to-normal intervals (SDANN), root mean square of successive differences (RMSSD), and high-frequency power (HF) and significantly higher AC and BMI. The ICPP group had significantly lower RMSSD and BMI than the simple obesity group (P<0.05). Compared with the ICPP girls without obesity, those with obesity had significantly lower DC, RMSSD, and HF and significantly higher AC and BMI (P<0.05). CONCLUSIONS: Cardiac autonomic dysfunction is seen in girls with ICPP, especially those with obesity, mainly presenting with reduced vagal tone.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/fisiopatologia
Coração/inervação
Puberdade Precoce/fisiopatologia
[Mh] Termos MeSH secundário: Índice de Massa Corporal
Criança
Pré-Escolar
Feminino
Frequência Cardíaca/fisiologia
Seres Humanos
Obesidade/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:29454386
[Au] Autor:Wang Y; Zhao Z; Zhu Z; Li P; Li X; Xue X; Duo J; Ma Y
[Ad] Endereço:Department of Digestion, Qinghai Provincial People's Hospital, Xining, Qinghai, 810007, China. rose19820721@126.com.
[Ti] Título:Telomere elongation protects heart and lung tissue cells from fatal damage in rats exposed to severe hypoxia.
[So] Source:J Physiol Anthropol;37(1):5, 2018 Feb 17.
[Is] ISSN:1880-6805
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The effects of acute hypoxia at high altitude on the telomere length of the cells in the heart and lung tissues remain unclear. This study aimed to investigate the change in telomere length of rat heart and lung tissue cells in response to acute exposure to severe hypoxia and its role in hypoxia-induced damage to heart and lung tissues. METHODS: Forty male Wistar rats (6-week old) were randomized into control group (n = 10) and hypoxia group (n = 30). Rats in control group were kept at an altitude of 1500 m, while rats in hypoxia group were exposed to simulated hypoxia with an altitude of 5000 m in a low-pressure oxygen chamber for 1, 3, and 7 days (n = 10). The left ventricular and right middle lobe tissues of each rat were collected for measurement of telomere length and reactive oxygen species (ROS) content, and the mRNA and protein levels of telomerase reverse transcriptase (TERT), hypoxia-inducible factor1α (HIF-1α), and hypoxia-inducible factor1α (HIF-2α). RESULTS: Increased exposure to hypoxia damaged rat heart and lung tissue cells and increased ROS production and telomere length. The mRNA and protein levels of TERT and HIF-1α were significantly higher in rats exposed to hypoxia and increased with prolonged exposure; mRNA and protein levels of HIF-2α increased only in rats exposed to hypoxia for 7 days. TERT was positively correlated with telomere length and the levels of HIF-1α but not HIF-2α. CONCLUSIONS: Acute exposure to severe hypoxia causes damage to heart and lung tissues due to the production of ROS but promotes telomere length and adaptive response by upregulating TERT and HIF-1α, which protect heart and lung tissue cells from fatal damage.
[Mh] Termos MeSH primário: Coração/fisiologia
Hipóxia/fisiopatologia
Pulmão/fisiologia
Telômero/fisiologia
[Mh] Termos MeSH secundário: Altitude
Animais
Translocador Nuclear Receptor Aril Hidrocarboneto/análise
Translocador Nuclear Receptor Aril Hidrocarboneto/metabolismo
Subunidade alfa do Fator 1 Induzível por Hipóxia/análise
Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo
Pulmão/citologia
Pulmão/patologia
Masculino
Miocárdio/citologia
Miocárdio/patologia
Ratos
Ratos Wistar
Espécies Reativas de Oxigênio/análise
Espécies Reativas de Oxigênio/metabolismo
Telomerase/análise
Telomerase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Hif1a protein, rat); 0 (Hypoxia-Inducible Factor 1, alpha Subunit); 0 (Reactive Oxygen Species); 138391-32-9 (Aryl Hydrocarbon Receptor Nuclear Translocator); EC 2.7.7.49 (Telomerase)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180219
[St] Status:MEDLINE
[do] DOI:10.1186/s40101-018-0165-y


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[PMID]:27776917
[Au] Autor:Luconi M; Raimondi L; Di Franco A; Mannucci E
[Ad] Endereço:Endocrinology Unit, Dept. Clinical and Experimental Biomedical Sciences, University of Florence, Viale G. Pieraccini, 6, Florence, Italy.
[Ti] Título:Which is the main molecular target responsible for the cardiovascular benefits in the EMPA-REG OUTCOME trial? A journey through the kidney, the heart and other interesting places.
[So] Source:Nutr Metab Cardiovasc Dis;26(12):1071-1078, 2016 12.
[Is] ISSN:1590-3729
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The results of the EMPA-REG-OUTCOME trial on type 2 diabetic patients at high risk for prior cardiovascular events showed that empagliflozin produces a remarkable reduction in the rates of hospitalization for heart failure (35%), cardiovascular death (38%), and all-cause death (32%). This unexpected cardio-protective action cannot be accounted for by the improvement of "classical" cardiovascular risk factors. AIMS: This review aims at summarizing current knowledge on the cardiovascular action of SGLT2 inhibitors and discuss the different hypotheses formulated to explain the results of the EMPA-REG-OUTCOME-study. DATA SYNTHESIS: We discuss in detail the major cardiovascular outcomes of the study in the light of the potential systemic and myocardial mechanisms of action of the drug. In addition, we propose and speculate on a direct effect of empagliflozin on cardiomyocytes. CONCLUSIONS: The available evidence is insufficient to establish any of the proposed mechanisms of cardiovascular action of empagliflozin. While awaiting for the results of ongoing clinical studies with other SGLT2 inhibitors, the most promising putative mechanisms still deserve to be confirmed with specifically designed, yet unavailable, pre-clinical studies.
[Mh] Termos MeSH primário: Compostos Benzidrílicos/uso terapêutico
Doenças Cardiovasculares/prevenção & controle
Diabetes Mellitus Tipo 2/tratamento farmacológico
Glucosídeos/uso terapêutico
Coração/fisiopatologia
Hipoglicemiantes/uso terapêutico
Rim/efeitos dos fármacos
Miócitos Cardíacos/efeitos dos fármacos
Transportador 2 de Glucose-Sódio/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Compostos Benzidrílicos/efeitos adversos
Doenças Cardiovasculares/mortalidade
Doenças Cardiovasculares/fisiopatologia
Ensaios Clínicos como Assunto
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/mortalidade
Diabetes Mellitus Tipo 2/fisiopatologia
Glucosídeos/efeitos adversos
Seres Humanos
Hipoglicemiantes/efeitos adversos
Rim/metabolismo
Rim/fisiopatologia
Miócitos Cardíacos/metabolismo
Medição de Risco
Fatores de Risco
Transportador 2 de Glucose-Sódio/metabolismo
Fatores de Tempo
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Benzhydryl Compounds); 0 (Glucosides); 0 (Hypoglycemic Agents); 0 (SLC5A2 protein, human); 0 (Sodium-Glucose Transporter 2); HDC1R2M35U (empagliflozin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:29242240
[Au] Autor:Carberry J; Carrick D; Haig C; Ahmed N; Mordi I; McEntegart M; Petrie MC; Eteiba H; Hood S; Watkins S; Lindsay M; Davie A; Mahrous A; Ford I; Sattar N; Welsh P; Radjenovic A; Oldroyd KG; Berry C
[Ad] Endereço:From the BHF Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences (J.C., D.C., N.A., I.M., M.M., M.C.P., H.E., S.H., S.W., M.L., A.D., A.M., N.S., P.W., A.R., K.G.O., C.B.) and Robertson Centre for Biostatistics (C.H., I.F.), University of Glasgow, Scotland; and W
[Ti] Título:Persistence of Infarct Zone T2 Hyperintensity at 6 Months After Acute ST-Segment-Elevation Myocardial Infarction: Incidence, Pathophysiology, and Prognostic Implications.
[So] Source:Circ Cardiovasc Imaging;10(12), 2017 Dec.
[Is] ISSN:1942-0080
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The incidence and clinical significance of persistent T2 hyperintensity after acute ST-segment-elevation myocardial infarction (STEMI) is uncertain. METHODS AND RESULTS: Patients who sustained an acute STEMI were enrolled in a cohort study (BHF MR-MI: NCT02072850). Two hundred eighty-three STEMI patients (mean age, 59±12 years; 75% male) had cardiac magnetic resonance with T2 mapping performed at 2 days and 6 months post-STEMI. Persisting T2 hyperintensity was defined as infarct T2 >2 SDs from remote T2 at 6 months. Infarct zone T2 was higher than remote zone T2 at 2 days (66.3±6.1 versus 49.7±2.1 ms; <0.001) and 6 months (56.8±4.5 versus 49.7±2.3 ms; <0.001). Remote zone T2 did not change over time (mean change, 0.0±2.7 ms; =0.837), whereas infarct zone T2 decreased (-9.5±6.4 ms; <0.001). At 6 months, T2 hyperintensity persisted in 189 (67%) patients, who were more likely to have Thrombus in Myocardial Infarction flow 0 or 1 in the culprit artery ( =0.020), incomplete ST-segment resolution ( =0.037), and higher troponin ( =0.024). Persistent T2 hyperintensity was associated with NT-proBNP (N-terminal pro-B-type natriuretic peptide) concentration (0.57 on a log scale [0.42-0.72]; =0.004) and the likelihood of adverse left ventricular remodeling (>20% change in left ventricular end-diastolic volume; 21.91 [2.75-174.29]; =0.004). Persistent T2 hyperintensity was associated with all-cause death and heart failure, but the result was not significant ( =0.051). ΔT2 was associated with all-cause death and heart failure ( =0.004) and major adverse cardiac events ( =0.013). CONCLUSIONS: Persistent T2 hyperintensity occurs in two thirds of STEMI patients. Persistent T2 hyperintensity was associated with the initial STEMI severity, adverse remodeling, and long-term health outcome. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02072850.
[Mh] Termos MeSH primário: Coração/diagnóstico por imagem
Coração/fisiopatologia
Imagem por Ressonância Magnética/métodos
Infarto do Miocárdio com Supradesnível do Segmento ST/diagnóstico por imagem
Infarto do Miocárdio com Supradesnível do Segmento ST/fisiopatologia
[Mh] Termos MeSH secundário: Doença Aguda
Feminino
Seguimentos
Seres Humanos
Incidência
Estudos Longitudinais
Masculino
Meia-Idade
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


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[PMID]:28463164
[Au] Autor:Penninkhof J; Spadola S; Breedveld S; Baaijens M; Lanconelli N; Heijmen B
[Ad] Endereço:Department of Radiation Oncology, Erasmus M.C. Cancer Institute, Rotterdam, The Netherlands. Electronic address: j.penninkhof@erasmusmc.nl.
[Ti] Título:Individualized Selection of Beam Angles and Treatment Isocenter in Tangential Breast Intensity Modulated Radiation Therapy.
[So] Source:Int J Radiat Oncol Biol Phys;98(2):447-453, 2017 06 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE AND OBJECTIVE: Propose a novel method for individualized selection of beam angles and treatment isocenter in tangential breast intensity modulated radiation therapy (IMRT). METHODS AND MATERIALS: For each patient, beam and isocenter selection starts with the fully automatic generation of a large database of IMRT plans (up to 847 in this study); each of these plans belongs to a unique combination of isocenter position, lateral beam angle, and medial beam angle. The imposed hard planning constraint on patient maximum dose may result in plans with unacceptable target dose delivery. Such plans are excluded from further analyses. Owing to differences in beam setup, database plans differ in mean doses to organs at risk (OARs). These mean doses are used to construct 2-dimensional graphs, showing relationships between: (1) contralateral breast dose and ipsilateral lung dose; and (2) contralateral breast dose and heart dose (analyzed only for left-sided). The graphs can be used for selection of the isocenter and beam angles with the optimal, patient-specific tradeoffs between the mean OAR doses. For 30 previously treated patients (15 left-sided and 15 right-sided tumors), graphs were generated considering only the clinically applied isocenter with 121 tangential beam angle pairs. For 20 of the 30 patients, 6 alternative isocenters were also investigated. RESULTS: Computation time for automatic generation of 121 IMRT plans took on average 30 minutes. The generated graphs demonstrated large variations in tradeoffs between conflicting OAR objectives, depending on beam angles and patient anatomy. For patients with isocenter optimization, 847 IMRT plans were considered. Adding isocenter position optimization next to beam angle optimization had a small impact on the final plan quality. CONCLUSION: A method is proposed for individualized selection of beam angles in tangential breast IMRT. This may be especially important for patients with cardiac risk factors or an enhanced risk for the development of contralateral breast cancer.
[Mh] Termos MeSH primário: Órgãos em Risco/efeitos da radiação
Planejamento da Radioterapia Assistida por Computador/métodos
Radioterapia de Intensidade Modulada/métodos
Neoplasias da Mama Unilaterais/radioterapia
[Mh] Termos MeSH secundário: Bases de Dados Factuais
Feminino
Coração/efeitos da radiação
Seres Humanos
Pulmão/efeitos da radiação
Dose de Radiação
Exposição à Radiação
Planejamento da Radioterapia Assistida por Computador/estatística & dados numéricos
Radioterapia de Intensidade Modulada/estatística & dados numéricos
Fatores de Tempo
Neoplasias da Mama Unilaterais/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29402248
[Au] Autor:Al-Afifi NA; Alabsi AM; Bakri MM; Ramanathan A
[Ad] Endereço:Department of Oral and Craniofacial Sciences, Faculty of Dentistry, University of Malaya, 50603, Kuala Lumpur, Malaysia.
[Ti] Título:Acute and sub-acute oral toxicity of Dracaena cinnabari resin methanol extract in rats.
[So] Source:BMC Complement Altern Med;18(1):50, 2018 Feb 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Dracaena cinnabari (DC) is a perennial tree that located on the Southern coast of Yemen native to the Socotra Island. This tree produces a deep red resin known as the Dragon's blood, the Twobrother's Blood or Damm Alakhwain. The current study performed to evaluate the safety of the DC resin methanol extract after a single or 28 consecutive daily oral administrations. METHODS: In assessing the safety of DC resin methanol extract, acute and sub-acute oral toxicity tests performed following OECD guidelines 423 and 407, respectively, with slight modifications. In acute oral toxicity test, DC resin methanol extract administered to female Sprague Dawley rats by oral gavage at a single dose of 300 and 2000 mg/kg body weight. Rats observed for toxic signs for 14 days. In sub-acute oral toxicity test, DC resin methanol extract administered to the rats by oral gavage at 500, 1000, and 1500 mg/kg body weight daily up to 28 days to male and female Spradgue Dawley rats. The control and high dose in satellite groups were also maintained and handled as the previous groups to determine the late onset toxicity of DC resin methanol extract. At the end of each test, hematological and biochemical analysis of the collected blood were performed as well as gross and microscopic pathology. RESULTS: In acute oral toxicity, no treatment-related death or toxic signs were observed. It revealed that the DC resin methanol extract could be well tolerated up to the dose 2000 mg/kg body weight and could be classified as Category 5. The sub-acute test observations indicated that there are no treatment-related changes up to the high dose level compared to the control. Food consumption, body weight, organ weight, hematological parameters, biochemical parameters and histopathological examination (liver, kidney, heart, spleen and lung) revealed no abnormalities. Water intake was significantly higher in the DC resin methanol extract treated groups compared to the control. CONCLUSION: This study demonstrates tolerability of DC resin methanol extract administered daily for 28 days up to 1500 mg/kg dose.
[Mh] Termos MeSH primário: Dracaena/química
Resinas Vegetais/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Peso Corporal/efeitos dos fármacos
Ingestão de Líquidos/efeitos dos fármacos
Ingestão de Alimentos/efeitos dos fármacos
Feminino
Coração/efeitos dos fármacos
Rim/efeitos dos fármacos
Masculino
Metanol
Tamanho do Órgão/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Resinas Vegetais/administração & dosagem
Testes de Toxicidade Aguda
Testes de Toxicidade Subcrônica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Resins, Plant); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180207
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2110-3



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