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[PMID]:28742769
[Au] Autor:Misra S; Koshy T; Shriram Lovhale P; Mathew T
[Ad] Endereço:From the *Department of Anesthesiology and †Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India.
[Ti] Título:Role of Transesophageal Echocardiography in Surgery for Hemitruncus Arteriosus.
[So] Source:Anesth Analg;125(4):1153-1155, 2017 Oct.
[Is] ISSN:1526-7598
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Aorta/anormalidades
Aorta/diagnóstico por imagem
Ecocardiografia Transesofagiana/métodos
Artéria Pulmonar/anormalidades
Artéria Pulmonar/diagnóstico por imagem
Tronco Arterial/diagnóstico por imagem
[Mh] Termos MeSH secundário: Aorta/cirurgia
Permeabilidade do Canal Arterial/diagnóstico por imagem
Permeabilidade do Canal Arterial/cirurgia
Seres Humanos
Lactente
Artéria Pulmonar/cirurgia
Tronco Arterial/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180117
[Lr] Data última revisão:
180117
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170726
[St] Status:MEDLINE
[do] DOI:10.1213/ANE.0000000000002306


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[PMID]:29173613
[Au] Autor:Steckham KE; Bhagra CJ; Siu SC; Silversides CK
[Ad] Endereço:Department of Medicine, Obstetric Medicine and Pregnancy and Heart Disease Programs, Mount Sinai Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada.
[Ti] Título:Pregnancy in Women With Repaired Truncus Arteriosus: A Case Series.
[So] Source:Can J Cardiol;33(12):1737.e1-1737.e3, 2017 Dec.
[Is] ISSN:1916-7075
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pregnancy in women with repaired truncus arteriosus (TA) is rare. We report the outcomes of 8 pregnancies in 4 women with surgically repaired TA. None of the women had adverse cardiac events during pregnancy. Two pregnancies, both in the same woman, were complicated by hypertensive disorders of pregnancy. The birth weight was less than the 10th percentile for gestational age in 3 pregnancies. Although women with repaired TA can do well during pregnancy, they require careful preconception assessment and surveillance.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos
Complicações Cardiovasculares na Gravidez
Persistência do Tronco Arterial/cirurgia
Tronco Arterial/cirurgia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Feminino
Seguimentos
Seres Humanos
Gravidez
Resultado da Gravidez
Estudos Retrospectivos
Tronco Arterial/diagnóstico por imagem
Persistência do Tronco Arterial/diagnóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171204
[Lr] Data última revisão:
171204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:28633267
[Au] Autor:Mroczek T; Demkow M; Moszura T; Morka A; Skalski J
[Ad] Endereço:Department of Pediatric Cardiac Surgery, Jagiellonian University, Krakow, Poland. Electronic address: t_mroczek@hotmail.com.
[Ti] Título:Perventricular Implantation of Melody Valve in Child With Pulmonary Hypertension After a Potts Shunt.
[So] Source:Ann Thorac Surg;104(1):e67-e69, 2017 Jul.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The Potts operation is a surgical option for the treatment of children with suprasystemic pulmonary arterial hypertension (PAH). Its positive hemodynamic effect may be obliterated by pulmonary valvar insufficiency. We describe a case in which the Potts shunt was followed by perventricular Melody valve implantation in the pulmonary position in a 12-kg child with a previously repaired truncus arteriosus communis (TAC) in whom PAH developed. The combined approach using both procedures significantly improved functional capacity and led to spectacular reverse remodeling of the right ventricle seen at 2-year follow-up. Elimination of significant pulmonary insufficiency is crucial in achieving the hemodynamic benefits of a Potts shunt in patients with pulmonary hypertension.
[Mh] Termos MeSH primário: Ventrículos do Coração/cirurgia
Hipertensão Pulmonar/cirurgia
Complicações Pós-Operatórias
Artéria Pulmonar/cirurgia
Insuficiência da Valva Pulmonar/cirurgia
Tronco Arterial/cirurgia
Procedimentos Cirúrgicos Vasculares/efeitos adversos
[Mh] Termos MeSH secundário: Anastomose Cirúrgica/efeitos adversos
Angiografia
Pré-Escolar
Ecocardiografia
Feminino
Ventrículos do Coração/diagnóstico por imagem
Seres Humanos
Hipertensão Pulmonar/diagnóstico
Hipertensão Pulmonar/etiologia
Insuficiência da Valva Pulmonar/diagnóstico
Insuficiência da Valva Pulmonar/etiologia
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170622
[St] Status:MEDLINE


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[PMID]:28346476
[Au] Autor:Racedo SE; Hasten E; Lin M; Devakanmalai GS; Guo T; Ozbudak EM; Cai CL; Zheng D; Morrow BE
[Ad] Endereço:Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, United States of America.
[Ti] Título:Reduced dosage of ß-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome.
[So] Source:PLoS Genet;13(3):e1006687, 2017 Mar.
[Is] ISSN:1553-7404
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The 22q11.2 deletion syndrome (22q11.2DS; velo-cardio-facial syndrome; DiGeorge syndrome) is a congenital anomaly disorder in which haploinsufficiency of TBX1, encoding a T-box transcription factor, is the major candidate for cardiac outflow tract (OFT) malformations. Inactivation of Tbx1 in the anterior heart field (AHF) mesoderm in the mouse results in premature expression of pro-differentiation genes and a persistent truncus arteriosus (PTA) in which septation does not form between the aorta and pulmonary trunk. Canonical Wnt/ß-catenin has major roles in cardiac OFT development that may act upstream of Tbx1. Consistent with an antagonistic relationship, we found the opposite gene expression changes occurred in the AHF in ß-catenin loss of function embryos compared to Tbx1 loss of function embryos, providing an opportunity to test for genetic rescue. When both alleles of Tbx1 and one allele of ß-catenin were inactivated in the Mef2c-AHF-Cre domain, 61% of them (n = 34) showed partial or complete rescue of the PTA defect. Upregulated genes that were oppositely changed in expression in individual mutant embryos were normalized in significantly rescued embryos. Further, ß-catenin was increased in expression when Tbx1 was inactivated, suggesting that there may be a negative feedback loop between canonical Wnt and Tbx1 in the AHF to allow the formation of the OFT. We suggest that alteration of this balance may contribute to variable expressivity in 22q11.2DS.
[Mh] Termos MeSH primário: Anormalidades Cardiovasculares/genética
Síndrome de DiGeorge/genética
Modelos Animais de Doenças
Proteínas com Domínio T-Box/genética
beta Catenina/genética
[Mh] Termos MeSH secundário: Animais
Apoptose/genética
Anormalidades Cardiovasculares/metabolismo
Diferenciação Celular/efeitos dos fármacos
Proliferação Celular/genética
Síndrome de DiGeorge/metabolismo
Perfilação da Expressão Gênica/métodos
Regulação da Expressão Gênica no Desenvolvimento
Seres Humanos
Hibridização In Situ
Mesoderma/citologia
Mesoderma/embriologia
Mesoderma/metabolismo
Camundongos Knockout
Camundongos Transgênicos
Microscopia de Fluorescência
Miócitos Cardíacos/metabolismo
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Proteínas com Domínio T-Box/metabolismo
Tronco Arterial/citologia
Tronco Arterial/embriologia
Tronco Arterial/metabolismo
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (T-Box Domain Proteins); 0 (Tbx1 protein, mouse); 0 (beta Catenin)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170328
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pgen.1006687


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[PMID]:28033080
[Au] Autor:Ramírez-Marroquín S; Curi-Curi PJ; Calderón-Colmenero J; García-Montes JA; Cervantes-Salazar JL
[Ad] Endereço:1 Department of Pediatric Cardiac and Congenital Heart Disease Surgery, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
[Ti] Título:Common Arterial Trunk Repair by Means of a Handmade Bovine Pericardial-Valved Woven Dacron Conduit.
[So] Source:World J Pediatr Congenit Heart Surg;8(1):69-76, 2017 Jan.
[Is] ISSN:2150-136X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Surgical repair of common arterial trunk (CAT) by means of a homograft conduit has become a standard practice. We report our experience in the correction of this heart disease with a handmade bovine pericardial-valved woven Dacron conduit as an alternative procedure to homografts, with a focus on early, mid-term, and long-term results. METHODS: We designed a retrospective study that included 15 patients with a mean age of 1.5 years (range: three months to eight years), who underwent primary repair of simple CAT. Right ventricular outflow tract was reconstructed in all the cases with this handmade graft that was explanted at the time of its biological stenotic degeneration. A peeling procedure was performed at this time, in order to reconstruct the right ventricle-to-pulmonary artery continuity. RESULTS: Overall mortality was 13.3% (one death at the early postoperative primary repair and the other at the mid-term postoperative peeling reoperation). Actuarial survival rate was 93.3%, 86.7%, and 86.7% at 5, 10, and 15 years, respectively. All of the 14 survivors developed stenosis of the handmade conduit at the mid-term period (8 ± 3 years), but after the peeling procedure, 13 survivors remain asymptomatic to date. CONCLUSIONS: Primary repair of common arterial trunk using a handmade conduit can be performed with very low perioperative mortality and satisfactory mid-term and long-term results, which can be favorably compared with those reported with the use of homografts. When graft obstruction develops, peeling procedure is a good option because it does not affect the overall survival, although long-term outcomes warrant further follow-up.
[Mh] Termos MeSH primário: Pericárdio/transplante
Polietilenotereftalatos
Próteses e Implantes
Persistência do Tronco Arterial/cirurgia
Tronco Arterial/cirurgia
[Mh] Termos MeSH secundário: Animais
Bovinos
Feminino
Seguimentos
Seres Humanos
Lactente
Masculino
Desenho de Prótese
Artéria Pulmonar/cirurgia
Reoperação
Estudos Retrospectivos
Taxa de Sobrevida/tendências
Transplante Homólogo
Tronco Arterial/anormalidades
Persistência do Tronco Arterial/mortalidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Polyethylene Terephthalates)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161230
[St] Status:MEDLINE
[do] DOI:10.1177/2150135116674439


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[PMID]:27995292
[Au] Autor:Gupta A; Kenny D; Caputo M; Amin Z
[Ad] Endereço:Children's Hospital of Georgia, Augusta University, 1120 15th Street BA 8300, Augusta, GA, 30912, USA.
[Ti] Título:Initial Experience with Elective Perventricular Melody Valve Placement in Small Patients.
[So] Source:Pediatr Cardiol;38(3):575-581, 2017 Mar.
[Is] ISSN:1432-1971
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Perventricular Melody valve placement has been described as a bailout approach or alternative RVOT approach in patients >30 kg. We present three patients <20 kg and two patients with limited venous access, where we electively performed the perventricular approach. Retrospective analysis of patients <30 kg and vascular access limitation undergoing elective hybrid pulmonary valve replacement were reviewed. The subcostal approach was performed without sternotomy with the sheath introduced through the diaphragmatic surface of the right ventricle. Diagnoses included tetralogy of Fallot (n = 3) and truncus arteriosus (n = 2). Mean weight was 16.2 kg (range 4.7-28.1 kg). Four patients had RV-PA conduits (size: 14-21 mm), and the fifth patient had a transannular patch. All patients met criteria for surgical valve replacement. Technical success was 100%. In two patients with absent pulmonary valve, the stent migrated during advancement of the delivery sheath. These stents were anchored in the distal main pulmonary artery (n = 1) or branch pulmonary artery (n = 1) without sequela. Tricuspid valve chordal injury occurred in one patient, where transesophageal echocardiogram (TEE) was not utilized. No patient required conversion to cardiopulmonary bypass. One patient with absent pulmonary valve died on follow-up as a consequence of severe airway compromise. Our initial experience demonstrates that the perventricular valve can be placed safely in small-sized patients. Advancement of the melody ensemble may be difficult and may cause stent migration. We conclude that the technique is feasible in small-sized patients and that prevention of complications includes placement of the stent at the time of the valve and TEE assistance in reducing tricuspid valve injury.
[Mh] Termos MeSH primário: Implante de Prótese de Valva Cardíaca
Insuficiência da Valva Pulmonar/diagnóstico por imagem
Tetralogia de Fallot/cirurgia
Tronco Arterial/cirurgia
[Mh] Termos MeSH secundário: Criança
Pré-Escolar
Ecocardiografia Transesofagiana
Próteses Valvulares Cardíacas
Seres Humanos
Lactente
Desenho de Prótese
Valva Pulmonar/cirurgia
Estudos Retrospectivos
Stents
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1007/s00246-016-1550-0


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[PMID]:28043469
[Au] Autor:Alfieris GM; Swartz MF
[Ad] Endereço:University of Rochester Medical Center, Rochester, New York. Electronic address: George_alfieris@urmc.rochester.edu.
[Ti] Título:The Initial Glimpse at Long-term Outcomes Following the Repair of Truncus Arteriosus.
[So] Source:Semin Thorac Cardiovasc Surg;28(2):512-513, 2016.
[Is] ISSN:1532-9488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The article by Naimo and colleagues (outcomes of truncus arteriosus repair in children: 35 years of experience from a single center) provides the initial glimpse at long-term outcomes following truncus arteriosus repair. Although survival has improved over the past decade, the morbidity resulting from subsequent re-operations now comprises a significant area for improvement in the ensuing decade.
[Mh] Termos MeSH primário: Persistência do Tronco Arterial
Tronco Arterial/cirurgia
[Mh] Termos MeSH secundário: Seres Humanos
Reoperação
[Pt] Tipo de publicação:EDITORIAL; COMMENT
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:28043468
[Au] Autor:Naimo PS; Fricke TA; Yong MS; d'Udekem Y; Kelly A; Radford DJ; Bullock A; Weintraub RG; Brizard CP; Konstantinov IE
[Ad] Endereço:Department of Cardiac Surgery, Royal Children׳s Hospital, Melbourne, Australia; University of Melbourne, Melbourne, Australia.
[Ti] Título:Outcomes of Truncus Arteriosus Repair in Children: 35 Years of Experience From a Single Institution.
[So] Source:Semin Thorac Cardiovasc Surg;28(2):500-511, 2016 Summer.
[Is] ISSN:1532-9488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We evaluated the long-term outcomes following repair of truncus arteriosus (TA) from a single institution. We conducted a retrospective review of children (n = 171) who underwent TA repair between 1979 and 2014. Early mortality rate was 11.7% (20/171). There were 19 late deaths. Most deaths (74%, 29/39) occurred within the first year following surgery. The 1-year mortality rate in 1979-2004 was 18% (25/136) and decreased to 11% (4/35) in 2005-2014. The overall survival rate was 73.6% at 30 years. Multivariate analysis identified postoperative extracorporeal membrane oxygenation (P = 0.003), operative weight <2.5kg (P = 0.012), prior surgical intervention (P = 0.018), and coronary artery anomaly (P = 0.037) as risk factors for early mortality. A Cox regression model identified DiGeorge syndrome (P = 0.008) as a risk factor for late mortality. Freedom from right ventricular outflow tract reoperation was 4.6% at 20 years. Concomitant truncal valve (TV) repair or replacement was undertaken in 20 patients. Additionally, 14 patients underwent late TV repair or replacement. The overall survival rate in patients who underwent TV operation was 76.9% at 20 years. A total of 19 patients had concomitant interrupted aortic arch with a survival rate of 89.5% at 20 years. Median follow-up was 19 years (mean = 17 years, range: 1-34 years). All patients were in New York Heart Association Class I/II at last follow-up. Following repair of TA, patients had good long-term functional status but had high reoperation rates. Repair of interrupted aortic arch and TV were not risk factors for mortality. Postoperative extracorporeal membrane oxygenation, operative weight <2.5kg, prior surgical intervention, and coronary artery anomaly were risk factors for early death. DiGeorge syndrome was associated with late death, most commonly from infection.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos
Cardiopatias Congênitas/cirurgia
Tronco Arterial/cirurgia
[Mh] Termos MeSH secundário: Peso ao Nascer
Peso Corporal
Procedimentos Cirúrgicos Cardíacos/efeitos adversos
Procedimentos Cirúrgicos Cardíacos/mortalidade
Criança
Pré-Escolar
Anomalias dos Vasos Coronários/mortalidade
Síndrome de DiGeorge/mortalidade
Intervalo Livre de Doença
Oxigenação por Membrana Extracorpórea
Feminino
Cardiopatias Congênitas/diagnóstico
Cardiopatias Congênitas/mortalidade
Cardiopatias Congênitas/fisiopatologia
Seres Humanos
Lactente
Recém-Nascido
Estimativa de Kaplan-Meier
Modelos Logísticos
Masculino
Análise Multivariada
Razão de Chances
Complicações Pós-Operatórias/etiologia
Complicações Pós-Operatórias/mortalidade
Complicações Pós-Operatórias/cirurgia
Modelos de Riscos Proporcionais
Reoperação
Estudos Retrospectivos
Fatores de Risco
Fatores de Tempo
Resultado do Tratamento
Tronco Arterial/anormalidades
Tronco Arterial/fisiopatologia
Vitória
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170104
[St] Status:MEDLINE


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[PMID]:27313056
[Au] Autor:Hurtado-Sierra D; Sánchez-Cornelio C; Vázquez-Antona CA; Buendía-Hernández A
[Ad] Endereço:Departamento de Ecocardiografía Pediátrica, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, México. Electronic address: meddani@hotmail.com.
[Ti] Título:[Unusual origin of truncus arteriosus from the right ventricle. Report of a case].
[Ti] Título:Origen poco habitual del tronco arterioso común desde el ventrículo derecho. A propósito de un caso..
[So] Source:Arch Cardiol Mex;86(3):282-3, 2016 Jul-Sep.
[Is] ISSN:1405-9940
[Cp] País de publicação:Mexico
[La] Idioma:spa
[Mh] Termos MeSH primário: Anormalidades Múltiplas
Ventrículos do Coração/anormalidades
Tronco Arterial/anormalidades
[Mh] Termos MeSH secundário: Anormalidades Múltiplas/diagnóstico por imagem
Adolescente
Ecocardiografia
Ventrículos do Coração/diagnóstico por imagem
Seres Humanos
Masculino
Tronco Arterial/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE


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[PMID]:27262857
[Au] Autor:Sharma A; Priya S; Jagia P
[Ad] Endereço:Department of Cardiac Radiology, All India Institute of Medical Sciences (AIIMS), New Delhi, 110029, India.
[Ti] Título:Persistent truncus arteriosus on dual source CT.
[So] Source:Jpn J Radiol;34(7):486-93, 2016 Jul.
[Is] ISSN:1867-108X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Persistent truncus arteriosus is a rare congenital cardiac disease with variable presentation. The exact preoperative diagnosis and delineation of anatomy are very important because the optimal timing and procedure for truncus arteriosus repair are decided on the basis of the morphological characteristics. Moreover, the presence of associated anomalies influences the surgical outcome and mortality in these patients. Dual-source computed tomographic evaluation with three-dimensional post-processing is highly valuable for delineating its precise morphology and to identify and characterize the associated anomalies. Also depiction of the precise aortic arch morphology and simultaneous evaluation of the airway are very useful in treatment planning. This pictorial review provides an overview of the imaging spectrum of truncus arteriosus and various associated anomalies as seen on dual-source computed tomography.
[Mh] Termos MeSH primário: Tomografia Computadorizada por Raios X/métodos
Persistência do Tronco Arterial/diagnóstico por imagem
[Mh] Termos MeSH secundário: Seres Humanos
Tronco Arterial/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160606
[St] Status:MEDLINE
[do] DOI:10.1007/s11604-016-0559-x



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