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[PMID]:29384600
[Au] Autor:Kondov S; Siepe M; Beyersdorf F; von Samson-Himmelstjern P; Czerny M
[Ad] Endereço:Department of Cardiovascular Surgery, University Heart Center Freiburg, Faculty of Medicine, University of Freiburg, Germany.
[Ti] Título:Thoracoabdominal aortic replacement with a bovine pericardial tube graft for aortobronchial fistulation 10 years after TEVAR.
[So] Source:Multimed Man Cardiothorac Surg;2017, 2017 Dec 20.
[Is] ISSN:1813-9175
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aortobronchial fistula after thoracic endovascular aortic repair is usually a late complication. It is associated with high mortality and its surgical management is technically challenging. This tutorial illustrates the steps involved in removing an infected stent graft and replacing it with a bovine pericardial tube graft.
[Mh] Termos MeSH primário: Aneurisma da Aorta Torácica/cirurgia
Doenças da Aorta/cirurgia
Implante de Prótese Vascular/efeitos adversos
Fístula Brônquica/cirurgia
Infecções Relacionadas à Prótese/cirurgia
Fístula Vascular/cirurgia
[Mh] Termos MeSH secundário: Animais
Doenças da Aorta/etiologia
Bioprótese
Prótese Vascular/efeitos adversos
Fístula Brônquica/etiologia
Bovinos
Remoção de Dispositivo
Procedimentos Endovasculares/efeitos adversos
Seres Humanos
Pericárdio/transplante
Infecções Relacionadas à Prótese/etiologia
Reoperação
Stents/efeitos adversos
Fístula Vascular/etiologia
[Pt] Tipo de publicação:VIDEO-AUDIO MEDIA
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180201
[St] Status:MEDLINE
[do] DOI:10.1510/mmcts.2017.027


  2 / 12709 MEDLINE  
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[PMID]:28460764
[Au] Autor:Pandian J; Kaur D; Yalagudri S; Devidutta S; Sundar G; Chennapragada S; Narasimhan C
[Ad] Endereço:CARE Hospital, Road No.1, Banjara Hills, Hyderabad 500 034, India.
[Ti] Título:Safety and efficacy of epicardial approach to catheter ablation of ventricular tachycardia - An institutional experience.
[So] Source:Indian Heart J;69(2):170-175, 2017 Mar - Apr.
[Is] ISSN:0019-4832
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND AIM: Epicardial approach to VT ablation increases the success rate of ablation but is not without complications. We studied the safety and efficacy of epicardial VT ablations performed at our institute. METHODS: All patients who underwent epicardial VT ablation at our institute were studied retrospectively. The outcome of VT ablation was among three groups: ischaemic cardiomyopathy (ICM), non-ischaemic cardiomyopathy (NICM) and granulomatous myocarditis (GM). Safety outcomes assessed included all complications considered to be due to pericardial access or epicardial mapping/ablation. RESULTS: A total of 54 patients (total 119 VTs, mean 2.2 (0.9)) were taken up for ablation procedure through epicardial access. Mean age: 47 (10) years, males: 83%. All patients had drug resistant recurrent VTs. The epicardial procedure was abandoned in three patients due to access issues; percutaneous sub-xiphoid access was employed in 48 and surgical approach in four patients. Complete success was achieved in 59% and partial success in 76%. The outcomes were poor in ICM patients as compared to those with GM and NICM. Overall success rates for all clinical VTs were 89% in GM, 90% in NICM and 67% in ICM. Success rates for epicardial VT ablation were 94%, 85% and 78% respectively for GM, NICM and ICM. Procedure related complications occurred in six patients. CONCLUSION: Epicardial ablation for VT offers good immediate outcomes with acceptable safety profile.
[Mh] Termos MeSH primário: Cateterismo Cardíaco/métodos
Ablação por Cateter/métodos
Sistema de Condução Cardíaco/cirurgia
Pericárdio/cirurgia
Taquicardia Ventricular/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Ecocardiografia
Técnicas Eletrofisiológicas Cardíacas/métodos
Feminino
Seguimentos
Sistema de Condução Cardíaco/fisiopatologia
Seres Humanos
Masculino
Meia-Idade
Estudos Retrospectivos
Taquicardia Ventricular/diagnóstico
Taquicardia Ventricular/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


  3 / 12709 MEDLINE  
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[PMID]:29390499
[Au] Autor:Xiang Y; Tu S; Zhang F
[Ad] Endereço:Department of Cardiothoracic Surgery, Zhejiang University, Lishui Center Hospital, Lishui, Zhejiang, P.R. China.
[Ti] Título:Rapid metastasis of mediastinal solitary fibrous tumor: Report a case.
[So] Source:Medicine (Baltimore);96(51):e9307, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Mediastinal solitary fibrous tumors (SFTs) are rare mesenchymal neoplasms. Complete resection is considered as the effective treatment and the prognosis is quite good. Rapid metastasis after surgery is extremely rare. PATIENT CONCERNS: In this case report we describe a 42-year-old man who present with a mediastinal malignant SFTs. Enhanced computed tomography of chest revealed a 4.5 × 4.0-cm mass in the anterior mediastinum. DIAGNOSES: The tumor is composed of massive proliferation of atypical spindle cells. Immunohistochemical staining for cluster of differentiation (CD) 34, CD99, and vimentin were strongly positive. INTERVENTIONS: Due to the possibility that the tumor was malignant, a standard median sternotomy was performed under general anesthesia. The mediastinal tumor and the affected part of the pericardium and right upper lobe of the lung were completely resected. OUTCOMES: The patient underwent surgery and recovered uneventfully. After 2 months follow-up postoperation, there was recurrence in the chest wall and right middle lung. The patient refused any treatment and was dead after 2 months. LESSONS: The present cases indicate that mediastinal SFTs should always be kept in mind for rapid metastasis. Once found, surgical intervention should be performed promptly. Due to the rapid metastasis, radiotherapy, and chemotherapy may be needed after surgery and long-term follow-up is required to monitor the metastasis of this type of tumor.
[Mh] Termos MeSH primário: Neoplasias Pulmonares/secundário
Neoplasias do Mediastino/patologia
Pericárdio/patologia
Tumores Fibrosos Solitários/patologia
[Mh] Termos MeSH secundário: Adulto
Evolução Fatal
Seres Humanos
Neoplasias Pulmonares/diagnóstico por imagem
Masculino
Neoplasias do Mediastino/diagnóstico por imagem
Neoplasias do Mediastino/cirurgia
Invasividade Neoplásica
Tumores Fibrosos Solitários/diagnóstico por imagem
Tumores Fibrosos Solitários/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009307


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[PMID]:28464933
[Au] Autor:da Silva RMS; de Mello RJV
[Ad] Endereço:Pathological Anatomy Service, Lauro Wanderley University Hospital, Federal University of Paraíba, João Pessoa, Paraíba, Brazil. ricellasouza@gmail.com.
[Ti] Título:Fat deposition in the left ventricle: descriptive and observacional study in autopsy.
[So] Source:Lipids Health Dis;16(1):86, 2017 May 02.
[Is] ISSN:1476-511X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The human heart contains varying amounts of fat deposits. Cardiac physiological fat occurs predominantly in the right ventricle (RV). The discovery and characterization of adipose tissue along the left ventricle (LV) has been rarely reported. This study aimed to determine the occurrence of fatty deposits in epicardial, pericoronay and myocardial compartments in the LV, and to trace the epidemiological profile and clinical associations with this finding. METHODS: Epidemiological and morphological data and heart samples were collected from corpses submitted to necropsy. Cardiac samples were fixed, embedded in paraffin and subjected to hematoxylin-eosin for microscopic study. RESULTS: The research was based on 40 samples of cardiac tissue, 21 male cadavers and 19 female ones with mean age of 68.2 years. 52.2% of the subjects had a history of smoking, 20% of them had alcohol consumption and 43.59% showed cardiac cause as a cause of death (acute myocardial infarction - AMI - was the most frequent immediate cause of death). 82.5% of the subjects showed atherosclerotic disease in the ascending aorta (ADAA). The fat deposition in the left ventricule (FDLV) was observed in 95% of cases. Epicardial fat (EF) and pericoronary adipose tissue (PAT) are the most frequent topographies in fat accumulation in the left heart chamber and the EF deposition is associated with myocardial adiposity (MA) (Fisher test [FT] 0.019; odds ratio [OR] 0.097 [95% CI 0.033 to 0.284]; p < 0.05). FDLV was associated with alcoholism (FT 0.04, OR 0.161 [95% CI 0.072 to 0.36]; p < 0.05); smoking (FT 0.508; OR 0581 [95% CI 0.431 to 0.73]; p < 0.05), presence of Frank's sign (FT 0.502; OR 0.567 [95% CI 0.414 to 0.775]; p < 0.05); ADAA (0.774 OR [95% CI 0.6405 to 0.936]; p < 0.05); AMI (OR 0.730 [95% CI 0.600 to 0.888]; p < 0.05) and macroscopic finding of cardiac hypertrophy (OR 0.700 [95% CI 0.525 to 0.933]; p < 0.05). FDLV is related with the thickness of the abdominal fat cushion. CONCLUSIONS: FDLV is common and associated with cardiovascular disease risk factors. Cardiac adiposity cannot be considered a random autopsy finding, requiring diagnostic research and more studies to investigate the clinical implications.
[Mh] Termos MeSH primário: Adiposidade
Aterosclerose/patologia
Cardiomegalia/patologia
Ventrículos do Coração/patologia
Infarto do Miocárdio/patologia
[Mh] Termos MeSH secundário: Tecido Adiposo/patologia
Adulto
Idoso
Idoso de 80 Anos ou mais
Alcoolismo/fisiopatologia
Aterosclerose/complicações
Autopsia
Cardiomegalia/complicações
Feminino
Seres Humanos
Masculino
Meia-Idade
Infarto do Miocárdio/complicações
Miocárdio/patologia
Pericárdio/patologia
Fatores de Risco
Fumar/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1186/s12944-017-0475-9


  5 / 12709 MEDLINE  
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[PMID]:29187109
[Au] Autor:Lugones I; Biancolini MF; Zerpa Pacheco VE; Martínez IA; Damsky Barbosa JMM; de Dios AMS
[Ad] Endereço:1 Pediatric Cardiac Surgery Unit, "Pedro de Elizalde" Children's Hospital, Buenos Aires, Argentina.
[Ti] Título:Modified In Situ Pericardial Rerouting Technique for Scimitar Syndrome Repair.
[So] Source:World J Pediatr Congenit Heart Surg;8(6):735-739, 2017 11.
[Is] ISSN:2150-136X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Scimitar syndrome repair represents a challenge due to the high incidence of postoperative pulmonary venous obstruction associated with classic surgical strategies. In situ pericardial rerouting technique has been considered a promising alternative approach due to its simplicity and excellent midterm results. Access to the left atrium can be difficult in young patients with severe dextrocardia and hypoplastic right lung. We describe a modification of the original rerouting technique in which the atrial septum is repositioned in order to create a wide opening in the lateral aspect of the left atrium and ensure an adequate size of the reconstructed pathway.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos/métodos
Átrios do Coração/cirurgia
Pericárdio/cirurgia
Veias Pulmonares/cirurgia
Síndrome de Cimitarra/cirurgia
[Mh] Termos MeSH secundário: Pré-Escolar
Seres Humanos
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:180202
[Lr] Data última revisão:
180202
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.1177/2150135117732540


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[PMID]:29174782
[Au] Autor:St-Onge S; Perrault LP; Demers P; Boyle EM; Gillinov AM; Cox J; Melby S
[Ad] Endereço:Department of Cardiac Surgery, Montreal Heart Institute, Université de Montréal, Quebec, Canada.
[Ti] Título:Pericardial Blood as a Trigger for Postoperative Atrial Fibrillation After Cardiac Surgery.
[So] Source:Ann Thorac Surg;105(1):321-328, 2018 Jan.
[Is] ISSN:1552-6259
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Prevention strategies have long been sought to reduce the incidence and burden of postoperative atrial fibrillation (POAF) after heart surgery. However, none has emerged as a dominant and widely applicable prophylactic measure. The purpose of this review is to consider the biological mechanisms by which shed mediastinal blood leads to oxidation and inflammation within the postoperative pericardial environment and how this might trigger POAF in susceptible persons, as well as how it could represent a new target for prevention of POAF. METHODS: We conducted a structured research of literature using PubMed and MEDLINE databases to May 2016. Biomolecular and clinical articles focused on assessing the contribution of pericardial blood, or the resulting inflammation within the pericardial space and its potential role in triggering POAF, were included in this review. RESULTS: Evidence suggests that shed mediastinal blood through breakdown products, activation of coagulation cascade, and oxidative burst contributes to a highly pro-oxidant and proinflammatory milieu found within the pericardial space that can trigger postoperative atrial fibrillation in susceptible persons. The extent of this reaction could be blunted by reducing the exposition of pericardium to blood either through posterior pericardiotomy or improved chest drainage. CONCLUSIONS: Shed mediastinal blood undergoing transformation within the pericardium appears to be an important contributing factor to POAF. Strategies to prevent shed mediastinal blood from pooling around the heart might be considered in developing future paradigms for prevention of POAF.
[Mh] Termos MeSH primário: Fibrilação Atrial/etiologia
Sangue
Procedimentos Cirúrgicos Cardíacos
Pericárdio
Complicações Pós-Operatórias/etiologia
[Mh] Termos MeSH secundário: Fibrilação Atrial/prevenção & controle
Fenômenos Fisiológicos Sanguíneos
Seres Humanos
Mediastino
Complicações Pós-Operatórias/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171228
[Lr] Data última revisão:
171228
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171128
[St] Status:MEDLINE


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[PMID]:29195576
[Au] Autor:Prabhu S; Armes JE; Bell D; Justo R; Venugopal P; Karl T; Alphonso N
[Ad] Endereço:Queensland Paediatric Cardiac Services, Lady Cilento Children's Hospital, Brisbane, Australia; School of Medicine, University of Queensland, Brisbane, Australia; Mater Research Institute, University of Queensland, Brisbane, Australia.
[Ti] Título:Histologic Evaluation of Explanted Tissue-Engineered Bovine Pericardium (CardioCel).
[So] Source:Semin Thorac Cardiovasc Surg;29(3):356-363, 2017 Autumn.
[Is] ISSN:1532-9488
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:CardioCel is a bovine pericardium that is subjected to a novel anticalcification tissue-engineering process. We present the histopathologic findings of human explants of CardioCel that were used in operations for congenital heart disease in children. Six explants were identified from 140 patients undergoing CardioCel implants from October 2012 to March 2015. CardioCel explants were evaluated histologically using hematoxylin and eosin, Masson trichrome, and immunohistochemical staining. A variable inflammatory response was seen in the surrounding native tissue, but not within the CardioCel graft in any of the explants. A neointimal layer of varying thickness developed on the visceral surface of 5 CardioCel explants with endothelialization of the longest duration explant. A granulation tissue layer developed on the parietal surface of the graft (consistently thicker than the neointima). Maintained collagen fiber architecture (laminated) and variable fibroblastic invasion (which increased with the age of the implant) were identified in all 6 cases. Scattered capillary vessels were noted in the majority of the explants with new collagen fibers in one, suggesting early remodeling. Calcium was seen in 1 explant at the interface of the graft and inflammatory response on its parietal surface. Evidence of graft remodeling was noted in the majority of the explants without inflammatory cells or calcification within the explanted graft material. A noticeable feature was the differential thickness of the host reaction to the parietal compared with the visceral surface of the graft. We will continue to evaluate CardioCel as a cardiovascular substitute for extracardiac and intracardiac reconstructions.
[Mh] Termos MeSH primário: Procedimentos Cirúrgicos Cardíacos
Remoção de Dispositivo
Cardiopatias Congênitas/cirurgia
Pericárdio/transplante
Engenharia Tecidual
Tecidos Suporte
[Mh] Termos MeSH secundário: Animais
Bovinos
Criança
Pré-Escolar
Xenoenxertos
Seres Humanos
Imuno-Histoquímica
Lactente
Recém-Nascido
Pericárdio/química
Pericárdio/patologia
Coloração e Rotulagem
Fatores de Tempo
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171226
[Lr] Data última revisão:
171226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171203
[St] Status:MEDLINE


  8 / 12709 MEDLINE  
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[PMID]:29242236
[Au] Autor:Haines DE; Wright M; Harks E; Deladi S; Fokkenrood S; Brink R; Belt H; Kolen AF; Mihajlovic N; Zuo F; Rankin D; Stoffregen W; Cockayne D; Cefalu J
[Ad] Endereço:From the Department of Cardiovascular Medicine, Beaumont Health System and Oakland University William Beaumont School of Medicine, Royal Oak, MI (D.E.H.,); St. Thomas' Hospital, London, United Kingdom (M.W.); Philips Healthcare, Best, The Netherlands (E.H., S.D., S.F., R.B.); Philips Research, Eindh
[Ti] Título:Near-Field Ultrasound Imaging During Radiofrequency Catheter Ablation: Tissue Thickness and Epicardial Wall Visualization and Assessment of Radiofrequency Ablation Lesion Formation and Depth.
[So] Source:Circ Arrhythm Electrophysiol;10(12), 2017 Dec.
[Is] ISSN:1941-3084
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Safe and successful radiofrequency catheter ablation depends on creation of transmural lesions without collateral injury to contiguous structures. Near-field ultrasound (NFUS) imaging through transducers in the tip of an ablation catheter may provide important information about catheter contact, wall thickness, and ablation lesion formation. METHODS AND RESULTS: NFUS imaging was performed using a specially designed open-irrigated radiofrequency ablation catheter incorporating 4 ultrasound transducers. Tissue/phantom thickness was measured in vitro with varying contact angles. In vivo testing was performed in 19 dogs with NFUS catheters positioned in 4 chambers. Wall thickness measurements were made at 222 sites (excluding the left ventricle) and compared with measurements from intracardiac echocardiography. Imaging was used to identify the epicardium with saline infusion into the pericardial space at 39 sites. In vitro, the measured exceeded actual tissue/phantom thickness by 13% to 20%. In vivo, NFUS reliably visualized electrode-tissue contact, but sensitivity of epicardial imaging was 92%. The chamber wall thickness measured by NFUS correlated well with intracardiac echocardiography ( =0.86; <0.0001). Sensitivity of lesion identification by NFUS was 94% for atrial and 95% for ventricular ablations. NFUS was the best parameter to predict lesion depth in right and left ventricle ( =0.47; <0.0001; multiple regression =0.0025). Lesion transmurality was correctly identified in 87% of atrial lesions. CONCLUSIONS: NFUS catheter imaging reliably assesses electrode-tissue contact and wall thickness. Its use during radiofrequency catheter ablation may allow the operator to assess the depth of ablation required for transmural lesion formation to optimize power delivery.
[Mh] Termos MeSH primário: Ablação por Cateter/métodos
Ecocardiografia/métodos
Pericárdio/diagnóstico por imagem
Pericárdio/cirurgia
[Mh] Termos MeSH secundário: Animais
Cateterismo Cardíaco
Cães
Fluoroscopia
Processamento de Imagem Assistida por Computador
Imagens de Fantasmas
Sensibilidade e Especificidade
Transdutores
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  9 / 12709 MEDLINE  
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[PMID]:28463437
[Au] Autor:Muta H; Sugita Y; Ohshima K; Otsubo H
[Ad] Endereço:Department of Pathology, Kurume University School of Medicine, Kurume, Japan.
[Ti] Título:Primary malignant pericardial sarcomatoid mesothelioma: An autopsy report.
[So] Source:Pathol Int;67(6):311-315, 2017 Jun.
[Is] ISSN:1440-1827
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Primary malignant pericardial sarcomatoid mesothelioma (PMPSM) is an extremely rare tumor with poor prognosis. We present an autopsy case in an 80-year-old man admitted for heart failure after one month of treatment at an outpatient clinic. He died three months after symptom onset. A complete autopsy revealed localization of the tumor to the pericardium without other lesions. Histologically, mainly spindle-shaped atypical cells with hyperchromatic nuclei and nucleoli were observed. Immunohistochemical markers for mesothelioma were positive for calretinin, cytokeratin AE1/AE3, and cytokeratin CAM5.2. Thus, we diagnosed primary sarcomatoid malignant mesothelioma of the pericardium. To our knowledge, only four PMPSM cases have been reported in the English literature in the past 30 years. Although PMPSM is rare, clinicians and pathologists should recognize it as a possible diagnosis of pericardial tumors. It is necessary to accumulate clinical and pathological diagnostic findings to establish early detection methods for this extremely rare disease.
[Mh] Termos MeSH primário: Biomarcadores Tumorais/metabolismo
Neoplasias Cardíacas/patologia
Neoplasias Pulmonares/patologia
Mesotelioma/patologia
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Autopsia
Neoplasias Cardíacas/diagnóstico
Neoplasias Cardíacas/metabolismo
Seres Humanos
Imuno-Histoquímica
Neoplasias Pulmonares/diagnóstico
Neoplasias Pulmonares/metabolismo
Masculino
Mesotelioma/diagnóstico
Mesotelioma/metabolismo
Pericárdio/metabolismo
Pericárdio/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers, Tumor)
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/pin.12535


  10 / 12709 MEDLINE  
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[PMID]:28452401
[Au] Autor:Heckbert SR; Wiggins KL; Blackshear C; Yang Y; Ding J; Liu J; McKnight B; Alonso A; Austin TR; Benjamin EJ; Curtis LH; Sotoodehnia N; Correa A
[Ad] Endereço:Department of Epidemiology, University of Washington, Seattle, Washington, USA.
[Ti] Título:Pericardial fat volume and incident atrial fibrillation in the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study.
[So] Source:Obesity (Silver Spring);25(6):1115-1121, 2017 Jun.
[Is] ISSN:1930-739X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To determine whether greater pericardial fat volume would be associated with increased risk of incident atrial fibrillation (AF). METHODS: In the Multi-Ethnic Study of Atherosclerosis and Jackson Heart Study, pericardial fat volume was quantified by computed tomography. Incident AF was identified from discharge diagnosis codes, study electrocardiograms, and Medicare claims. RESULTS: Among 7,991 participants, 40% were African American, 32% white, 18% Hispanic, and 10% Chinese American; mean age was 62 years; 55% were women. During an average of 10.0 years of follow-up in the Multi-Ethnic Study of Atherosclerosis and 4.5 years in the Jackson Heart Study, 756 incident AF cases were identified. After adjustment for age, sex, study, race/ethnicity, height, glucose status, systolic blood pressure, treated hypertension, and BMI, greater pericardial fat volume was associated with higher AF risk in Hispanics (hazard ratio 1.24 per SD, 95% confidence interval 1.05-1.46) but not overall (hazard ratio 1.06, 95% confidence interval 0.97-1.15). In mediation analysis, pericardial fat volume partially mediated the association of BMI with incident AF in Hispanics. CONCLUSIONS: After adjustment for BMI, greater pericardial fat volume was associated with incident AF in Hispanics but not overall. Additional research is needed on the mechanisms by which pericardial fat volume is related to increased AF risk and possible differences by race/ethnicity.
[Mh] Termos MeSH primário: Gordura Abdominal/metabolismo
Tecido Adiposo/fisiopatologia
Aterosclerose/etnologia
Fibrilação Atrial/etnologia
Doenças Cardiovasculares/etnologia
Pericárdio/anormalidades
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Aterosclerose/terapia
Fibrilação Atrial/terapia
Doenças Cardiovasculares/complicações
Grupos Étnicos
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171205
[Lr] Data última revisão:
171205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1002/oby.21835



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