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[PMID]:28462392
[Au] Autor:Li WC; Zhu XY; Ritson E
[Ad] Endereço:University of St Andrews, St Andrews, Fife KY16 9JP, Scotland.
[Ti] Título:Mechanosensory Stimulation Evokes Acute Concussion-Like Behavior by Activating GIRKs Coupled to Muscarinic Receptors in a Simple Vertebrate.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most vertebrates show concussion responses when their heads are hit suddenly by heavy objects. Previous studies have focused on the direct physical injuries to the neural tissue caused by the concussive blow. We study a similar behavior in a simple vertebrate, the tadpole. We find that concussion-like behavior can be reliably induced by the mechanosensory stimulation of the head skin without direct physical impacts on the brain. Head skin stimulation activates a cholinergic pathway which then opens G protein-coupled inward-rectifying potassium channels (GIRKs) via postsynaptic M muscarinic receptors to inhibit brainstem neurons critical for the initiation and maintenance of swimming for up to minutes and can explain many features commonly observed immediately after concussion. We propose that some acute symptoms of concussion in vertebrates can be explained by the opening of GIRKs following mechanosensory stimulation to the head.
[Mh] Termos MeSH primário: Acetilcolina/metabolismo
Canais de Potássio Corretores do Fluxo de Internalização Acoplados a Proteínas G/metabolismo
Neurônios/metabolismo
Receptores Muscarínicos/metabolismo
[Mh] Termos MeSH secundário: Animais
Concussão Encefálica/metabolismo
Tronco Encefálico/metabolismo
Seres Humanos
Oócitos/metabolismo
Vertebrados/metabolismo
Xenopus laevis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (G Protein-Coupled Inwardly-Rectifying Potassium Channels); 0 (Receptors, Muscarinic); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:28463155
[Au] Autor:Nanda RH; Ganju RG; Schreibmann E; Chen Z; Zhang C; Jegadeesh N; Cassidy R; Deng C; Eaton BR; Esiashvili N
[Ad] Endereço:Department of Radiation Oncology, Winship Cancer Institute, Emory University College of Medicine, Atlanta, Georgia. Electronic address: rhazari@emory.edu.
[Ti] Título:Correlation of Acute and Late Brainstem Toxicities With Dose-Volume Data for Pediatric Patients With Posterior Fossa Malignancies.
[So] Source:Int J Radiat Oncol Biol Phys;98(2):360-366, 2017 06 01.
[Is] ISSN:1879-355X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Radiation-induced brainstem toxicity after treatment of pediatric posterior fossa malignancies is incompletely understood, especially in the era of intensity modulated radiation therapy (IMRT). The rates of, and predictive factors for, brainstem toxicity after photon RT for posterior fossa tumors were examined. METHODS AND MATERIALS: After institutional review board approval, 60 pediatric patients treated at our institution for nonmetastatic infratentorial ependymoma and medulloblastoma with IMRT were included in the present analysis. Dosimetric variables, including the mean and maximum dose to the brainstem, the dose to 10% to 90% of the brainstem (in 10% increments), and the volume of the brainstem receiving 40, 45, 50, and 55 Gy were recorded for each patient. Acute (onset within 3 months) and late (>3 months of RT completion) RT-induced brainstem toxicities with clinical and radiographic correlates were scored using Common Terminology Criteria for Adverse Events, version 4.0. RESULTS: Patients aged 1.4 to 21.8 years underwent IMRT or volumetric arc therapy postoperatively to the posterior fossa or tumor bed. At a median clinical follow-up period of 2.8 years, 14 patients had developed symptomatic brainstem toxicity (crude incidence 23.3%). No correlation was found between the dosimetric variables examined and brainstem toxicity. Vascular injury or ischemia showed a strong trend toward predicting brainstem toxicity (P=.054). Patients with grade 3 to 5 brainstem toxicity had undergone treatment to significant volumes of the posterior fossa. CONCLUSION: The results of the present series demonstrate a low, but not negligible, risk of brainstem radiation necrosis for pediatric patients with posterior fossa malignancies treated with IMRT. No specific dose-volume correlations were identified; however, modern treatment volumes might help limit the incidence of severe toxicity. Additional work investigating inherent biologic sensitivity might also provide further insight into this clinical problem.
[Mh] Termos MeSH primário: Tronco Encefálico/efeitos da radiação
Neoplasias Cerebelares/radioterapia
Ependimoma/radioterapia
Neoplasias Infratentoriais/radioterapia
Meduloblastoma/radioterapia
Lesões por Radiação/patologia
Radioterapia de Intensidade Modulada/efeitos adversos
[Mh] Termos MeSH secundário: Doença Aguda
Adolescente
Tronco Encefálico/patologia
Neoplasias Cerebelares/patologia
Neoplasias Cerebelares/cirurgia
Criança
Pré-Escolar
Ependimoma/patologia
Ependimoma/cirurgia
Feminino
Seguimentos
Seres Humanos
Lactente
Neoplasias Infratentoriais/patologia
Neoplasias Infratentoriais/cirurgia
Masculino
Meduloblastoma/patologia
Meduloblastoma/cirurgia
Necrose/etiologia
Dosagem Radioterapêutica
Radioterapia de Intensidade Modulada/métodos
Fatores de Tempo
Carga Tumoral
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:29371650
[Au] Autor:Sheikhbahaei S; Turovsky EA; Hosford PS; Hadjihambi A; Theparambil SM; Liu B; Marina N; Teschemacher AG; Kasparov S; Smith JC; Gourine AV
[Ad] Endereço:Centre for Cardiovascular and Metabolic Neuroscience, Department of Neuroscience, Physiology and Pharmacology, University College London, London, WC1E 6BT, UK.
[Ti] Título:Astrocytes modulate brainstem respiratory rhythm-generating circuits and determine exercise capacity.
[So] Source:Nat Commun;9(1):370, 2018 01 25.
[Is] ISSN:2041-1723
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Astrocytes are implicated in modulation of neuronal excitability and synaptic function, but it remains unknown if these glial cells can directly control activities of motor circuits to influence complex behaviors in vivo. This study focused on the vital respiratory rhythm-generating circuits of the preBötzinger complex (preBötC) and determined how compromised function of local astrocytes affects breathing in conscious experimental animals (rats). Vesicular release mechanisms in astrocytes were disrupted by virally driven expression of either the dominant-negative SNARE protein or light chain of tetanus toxin. We show that blockade of vesicular release in preBötC astrocytes reduces the resting breathing rate and frequency of periodic sighs, decreases rhythm variability, impairs respiratory responses to hypoxia and hypercapnia, and dramatically reduces the exercise capacity. These findings indicate that astrocytes modulate the activity of CNS circuits generating the respiratory rhythm, critically contribute to adaptive respiratory responses in conditions of increased metabolic demand and determine the exercise capacity.
[Mh] Termos MeSH primário: Astrócitos/fisiologia
Tronco Encefálico/fisiologia
Periodicidade
Condicionamento Físico Animal/fisiologia
Respiração
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Adenoviridae/genética
Adenoviridae/metabolismo
Animais
Animais Recém-Nascidos
Astrócitos/citologia
Tronco Encefálico/citologia
Cálcio/metabolismo
Feminino
Regulação da Expressão Gênica
Vetores Genéticos/química
Vetores Genéticos/metabolismo
Hipercapnia/metabolismo
Hipercapnia/fisiopatologia
Hipóxia/metabolismo
Hipóxia/fisiopatologia
Masculino
Bulbo/citologia
Bulbo/fisiologia
Cultura Primária de Células
Ratos
Ratos Sprague-Dawley
Proteínas SNARE/antagonistas & inibidores
Proteínas SNARE/genética
Proteínas SNARE/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., INTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (SNARE Proteins); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180215
[Lr] Data última revisão:
180215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180127
[St] Status:MEDLINE
[do] DOI:10.1038/s41467-017-02723-6


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[PMID]:29262513
[Au] Autor:Guo FB; Cai CS; Zhang WJ; Hong JS; Lan LZ; Chen XY
[Ad] Endereço:The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.
[Ti] Título:[Calculating the Hausdorff distance based on the scripting in RayStation treatment planning system].
[So] Source:Zhonghua Zhong Liu Za Zhi;39(12):942-945, 2017 Dec 23.
[Is] ISSN:0253-3766
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:To calculate out the Hausdorff distance based on the scripting in RayStation treatment planning system, which was then applied in measuring the deformation error of brain stem during image automatic registration between CT and MR. Scripting was edited in RayStation system (version 4.7) by using IronPython. The set of point coordinates on the contour of any two region of interest (ROI) had been found firstly, then the Hausdorff distance between the two point sets was calculated out. A graphical user interface (GUI) was designed by using XAML to acquire the visualized output of Hausdorff distance. GUI appeared when the script was run, where two ROIs was selected, then the corresponding Hausdorff distance and the running time were displayed by pressing the "Calculate" button. The mean Hausdorff distance of brain stem in 20 patients with head and neck neoplasms was 1.20 cm while the mean elapsed time was 11.01s. Hausdorff distance of any two ROIs can be calculated out by using the developed method. GUI is designed to realize the visual interaction with RayStation system. Therefore, the RayStation system satisfies the demands of Hausdorff distance calculation in both clinical and research work.
[Mh] Termos MeSH primário: Tronco Encefálico/diagnóstico por imagem
Neoplasias de Cabeça e Pescoço/diagnóstico por imagem
Imagem por Ressonância Magnética
Planejamento da Radioterapia Assistida por Computador/métodos
Tomografia Computadorizada por Raios X
[Mh] Termos MeSH secundário: Algoritmos
Seres Humanos
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.3760/cma.j.issn.0253-3766.2017.12.012


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[PMID]:28450776
[Au] Autor:Tolesa K; Gebreal GW
[Ad] Endereço:Department of Ophthalmology, Jimma University, Ethiopia.
[Ti] Título:Brainstem Anesthesia after Retrobulbar Block: A Case Report and Review of Literature.
[So] Source:Ethiop J Health Sci;26(6):589-594, 2016 Nov.
[Is] ISSN:2413-7170
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Retro-bulbar anesthesia is one of the most common regional blocks used for intraocular surgeries. Complications associated with regional blocks may be limited to the eye or may be systemic. CASE REPORT: After a retro-bulbar block for glaucoma surgery, a 60-year-old man developed loss of consciousness, apnea with hypotension and bradycardia-features of brainstem anesthesia. We present the clinical features, treatment and comments on how to prevent the problem as well as a review of the literature on reported cases. CONCLUSION: Although it is rare, treating physicians should be aware of the potentially lethal consequences of retro-bulbar block, understand measures to reduce the risks and early recognition and treatment. Facilities where ophthalmic surgeries are performed under local anesthesia should be properly equipped and staffed for advanced resuscitation.
[Mh] Termos MeSH primário: Anestésicos Locais/efeitos adversos
Tronco Encefálico/efeitos dos fármacos
Bupivacaína/efeitos adversos
Trabeculectomia/efeitos adversos
[Mh] Termos MeSH secundário: Anestésicos Locais/administração & dosagem
Apneia/induzido quimicamente
Bupivacaína/administração & dosagem
Glaucoma/cirurgia
Seres Humanos
Hipotensão/induzido quimicamente
Masculino
Meia-Idade
Trabeculectomia/métodos
Inconsciência/induzido quimicamente
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, Local); Y8335394RO (Bupivacaine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180205
[Lr] Data última revisão:
180205
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28461602
[Au] Autor:Paolocci N; Cannavo A; Chelko SP; Montano N
[Ad] Endereço:From the Division of Cardiology, Johns Hopkins Medical Institutions, Baltimore, MD (N.P., S.P.C.); Department of Experimental Medicine, Universita' di Perugia, Italy (N.P.); Lewis Katz School of Medicine, Temple University, Philadelphia, PA (A.C.); and Fondazione IRCSS Ca' Granda, Ospedale Maggiore
[Ti] Título:Burning Redoxstats in the Brainstem: Lack of Nrf2 and the Rise of Hypertension.
[So] Source:Hypertension;69(6):1019-1021, 2017 06.
[Is] ISSN:1524-4563
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Hipertensão
Fator 2 Relacionado a NF-E2
[Mh] Termos MeSH secundário: Tronco Encefálico
Seres Humanos
[Pt] Tipo de publicação:EDITORIAL; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T; COMMENT
[Nm] Nome de substância:
0 (NF-E2-Related Factor 2)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180116
[Lr] Data última revisão:
180116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1161/HYPERTENSIONAHA.117.09238


  7 / 28788 MEDLINE  
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[PMID]:28448978
[Au] Autor:Yoshida T; Yasuda R; Mizuta I; Nakagawa M; Mizuno T; JAPAN Alexander Disease Study Group
[Ad] Endereço:Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
[Ti] Título:Quantitative Evaluation of Brain Stem Atrophy Using Magnetic Resonance Imaging in Adult Patients with Alexander Disease.
[So] Source:Eur Neurol;77(5-6):296-302, 2017.
[Is] ISSN:1421-9913
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Brain MRI in adult patients with Alexander disease (AxD) mainly shows atrophy in the medulla oblongata. However, currently there is no quantitative standard for assessing this atrophy. In this study, we quantitatively evaluated the brain stem of AxD patients with glial fibrillary acidic protein (GFAP) mutation using conventional MRI to evaluate its usefulness as an aid to diagnosing AxD in daily clinical practice. Nineteen AxD patients with GFAP mutation were compared with 14 patients negative for GFAP mutation in whom AxD was suspected due to "atrophy of the medulla oblongata." In the GFAP mutation-positive group, the sagittal diameter of the medulla oblongata, the ratio of the diameter of the medulla oblongata to that of the midbrain (MO/MB), and the ratio of the sagittal diameter of the medulla oblongata to that of the pons (MO/Po) were significantly smaller compared to those of the GFAP mutation-negative group (p < 0.01). The sensitivity and specificity of each parameter were 87.5 and 92.3%, 91.7 and 81.3%, and 88.2 and 100% with a sagittal diameter of the medulla oblongata <9.0 mm, MO/MB <0.60, and sagittal MO/Po <0.46, respectively. These parameters can provide very useful information to differentially diagnose AxD from other disorders associated with brain stem atrophy in adult patients.
[Mh] Termos MeSH primário: Doença de Alexander/diagnóstico por imagem
Doença de Alexander/patologia
Tronco Encefálico/diagnóstico por imagem
Tronco Encefálico/patologia
[Mh] Termos MeSH secundário: Adulto
Atrofia/diagnóstico por imagem
Atrofia/patologia
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180108
[Lr] Data última revisão:
180108
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170428
[St] Status:MEDLINE
[do] DOI:10.1159/000475661


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[PMID]:28464295
[Au] Autor:Stewart M; Kollmar R; Nakase K; Silverman J; Sundaram K; Orman R; Lazar J
[Ad] Endereço:Department of Neurology, SUNY Downstate Medical Center, Brooklyn, New York, U.S.A.
[Ti] Título:Obstructive apnea due to laryngospasm links ictal to postictal events in SUDEP cases and offers practical biomarkers for review of past cases and prevention of new ones.
[So] Source:Epilepsia;58(6):e87-e90, 2017 06.
[Is] ISSN:1528-1167
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Seizure spread into autonomic and respiratory brainstem regions is thought to play an important role in sudden unexpected death in epilepsy (SUDEP). As the clinical dataset of cases of definite SUDEP available for study grows, evidence points to a sequence of events that includes postictal apnea, bradycardia, and asystole as critical events that can lead to death. One possible link between the precipitating seizure and the critical postictal sequence is seizure-driven laryngospasm sufficient to completely obstruct the airway for an extended period, but ictal laryngospasm is difficult to fully assess. Herein, we demonstrate in a rat model how the electrical artifacts of attempts to inspire during airway obstruction and features of the cardiac rhythm establish this link between ictal and postictal activity and can be used as practical biomarkers of obstructive apnea due to laryngospasm or other causes of airway obstruction.
[Mh] Termos MeSH primário: Sistema Nervoso Autônomo/fisiopatologia
Biomarcadores
Tronco Encefálico/fisiopatologia
Morte Súbita/etiologia
Morte Súbita/prevenção & controle
Modelos Animais de Doenças
Eletrocardiografia
Eletromiografia
Epilepsia/complicações
Epilepsia/fisiopatologia
Laringismo/complicações
Laringismo/fisiopatologia
Centro Respiratório/fisiopatologia
Processamento de Sinais Assistido por Computador
Apneia Obstrutiva do Sono/complicações
Apneia Obstrutiva do Sono/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Masculino
Ratos Sprague-Dawley
Fatores de Risco
Convulsões/complicações
Convulsões/fisiopatologia
Trabalho Respiratório
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180107
[Lr] Data última revisão:
180107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1111/epi.13765


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[PMID]:28450396
[Au] Autor:Lei W; Mullen N; McCarthy S; Brann C; Richard P; Cormier J; Edwards K; Bilsky EJ; Streicher JM
[Ad] Endereço:From the Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724.
[Ti] Título:Heat-shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK mitogen-activated protein kinase (MAPK) mechanism in mouse brain.
[So] Source:J Biol Chem;292(25):10414-10428, 2017 06 23.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent advances in developing opioid treatments for pain with reduced side effects have focused on the signaling cascades of the µ-opioid receptor (MOR). However, few such signaling targets have been identified for exploitation. To address this need, we explored the role of heat-shock protein 90 (Hsp90) in opioid-induced MOR signaling and pain, which has only been studied in four previous articles. First, in four cell models of MOR signaling, we found that Hsp90 inhibition for 24 h with the inhibitor 17- -allylamino-17-demethoxygeldanamycin (17-AAG) had different effects on protein expression and opioid signaling in each line, suggesting that cell models may not be reliable for predicting pharmacology with this protein. We thus developed an model using CD-1 mice with an intracerebroventricular injection of 17-AAG for 24 h. We found that Hsp90 inhibition strongly blocked morphine-induced anti-nociception in models of post-surgical and HIV neuropathic pain but only slightly blocked anti-nociception in a naive tail-flick model, while enhancing morphine-induced precipitated withdrawal. Seeking a mechanism for these changes, we found that Hsp90 inhibition blocks ERK MAPK activation in the periaqueductal gray and caudal brain stem. We tested these signaling changes by inhibiting ERK in the above-mentioned pain models and found that ERK inhibition could account for all of the changes in anti-nociception induced by Hsp90 inhibition. Taken together, these findings suggest that Hsp90 promotes opioid-induced anti-nociception by an ERK mechanism in mouse brain and that Hsp90 could be a future target for improving the therapeutic index of opioid drugs.
[Mh] Termos MeSH primário: Analgésicos Opioides/farmacologia
Benzoquinonas/farmacologia
Tronco Encefálico/metabolismo
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Proteínas de Choque Térmico HSP90/metabolismo
Lactamas Macrocíclicas/farmacologia
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Nociceptividade/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Tronco Encefálico/patologia
Células CHO
Cricetinae
Cricetulus
Células HEK293
Seres Humanos
Masculino
Camundongos
Neuralgia/tratamento farmacológico
Neuralgia/metabolismo
Neuralgia/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Benzoquinones); 0 (HSP90 Heat-Shock Proteins); 0 (Lactams, Macrocyclic); 4GY0AVT3L4 (tanespimycin); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171229
[Lr] Data última revisão:
171229
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M116.769489


  10 / 28788 MEDLINE  
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[PMID]:29187935
[Au] Autor:Ennaqui K; Makayssi A; Boufettal H; Samouh N
[Ad] Endereço:Centre Hospitalier Universitaire Ibn Rochd, Faculty of Medecine and Pharmacy, Hassan II University of Casablanca, Morocco.
[Ti] Título:[Haemorrhagic stroke of the brainstem secondary to postpartum eclampsia: about a case and literature review].
[Ti] Título:Accident vasculaire cérébral hémorragique du tronc cérébral suite à une éclampsie du post partum: à propos d'un cas et revue de la littérature..
[So] Source:Pan Afr Med J;27:266, 2017.
[Is] ISSN:1937-8688
[Cp] País de publicação:Uganda
[La] Idioma:fre
[Ab] Resumo:Strokes are rare but severe accidents during pregnancy and post-partum period. They are responsible for high mortality and morbidity rates. Pre-eclampsia, eclampsia, and strokes are significantly related. Endothelial dysfunction, alteration of brain self-regulation and severe hypertension are, probably, the cause of many strokes in pregnant women and during postpartum period. We report a case of hemorrhagic stroke of the brainstem in a nonmonitored 21-year old patient at 38 weeks pregnant admitted with severe preeclampsia complicated by eclampsia and then by haemorrhagic stroke of the brainstem on the second post-operative day after cesarean section performed due to suspicion of retroplacental haematoma arisen since her admission. Intracerebral hemorrhage is a rare but severe complication in post-partum women. Several studies are underway to fill the gaps of knowledge involved in the management of pre-eclamptic patients with neurological complications.
[Mh] Termos MeSH primário: Eclampsia/fisiopatologia
Hemorragias Intracranianas/etiologia
Transtornos Puerperais/fisiopatologia
Acidente Vascular Cerebral/etiologia
[Mh] Termos MeSH secundário: Tronco Encefálico/patologia
Cesárea
Feminino
Seres Humanos
Período Pós-Parto
Pré-Eclâmpsia/fisiopatologia
Gravidez
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171219
[Lr] Data última revisão:
171219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.11604/pamj.2017.27.266.12288



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