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  1 / 26 MEDLINE  
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[PMID]:29187687
[Au] Autor:Takeuchi Y; Kaga T; Ieda M; Kojima Y; Ochiai J; Mabuchi C
[Ad] Endereço:Department of Neurology, Nagoya Ekisaikai Hospital.
[Ti] Título:[Symmetrical lesions of the cerebral peduncles and internal capsules on MRI in a patient with extranodal NK/T cell lymphoma].
[So] Source:Rinsho Shinkeigaku;57(12):778-781, 2017 Dec 27.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A 72-year-old man was admitted to our hospital because of subacute progressive consciousness disturbance. FLAIR images showed diffuse high intensity areas in the bilateral thalamus, basal ganglia, and white matter. Chest CT revealed a mass in the right lung. The patient was diagnosed with extranodal natural killer/T cell lymphoma (ENKL) according to the results of a biopsy of the right pulmonary mass. The FLAIR images showed diffuse white matter lesions, without a mass such as lymphomatosis cerebri. On diffusion-weighted images, symmetrical high-intensity lesions of the cerebral peduncle and the internal capsule suggested high-density lymphoma cells around neurons. ENKL of the central nervous system and lung is a very rare neoplasm, and this case showed characteristic images.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Pedúnculo Cerebral/diagnóstico por imagem
Imagem de Difusão por Ressonância Magnética
Cápsula Interna/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
Linfoma Extranodal de Células T-NK/diagnóstico por imagem
Neoplasias Primárias Múltiplas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Neoplasias Encefálicas/patologia
Pedúnculo Cerebral/patologia
Seres Humanos
Cápsula Interna/patologia
Pulmão/patologia
Neoplasias Pulmonares/patologia
Linfoma Extranodal de Células T-NK/patologia
Masculino
Neoplasias Primárias Múltiplas/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001076


  2 / 26 MEDLINE  
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[PMID]:27888085
[Au] Autor:Celtikci E; Celtikci P; Fernandes-Cabral DT; Ucar M; Fernandez-Miranda JC; Borcek AO
[Ad] Endereço:Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA; Division of Pediatric Neurosurgery, Department of Neurosurgery, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey. Electronic address: drceltikci@gmail.com.
[Ti] Título:High-Definition Fiber Tractography in Evaluation and Surgical Planning of Thalamopeduncular Pilocytic Astrocytomas in Pediatric Population: Case Series and Review of Literature.
[So] Source:World Neurosurg;98:463-469, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Thalamopeduncular tumors (TPTs) of childhood present a challenge for neurosurgeons due to their eloquent location. Preoperative fiber tracking provides total or near-total resection, without additional neurologic deficit. High-definition fiber tractography (HDFT) is an advanced white matter imaging technique derived from magnetic resonance imaging diffusion data, shown to overcome the limitations of diffusion tensor imaging. We aimed to investigate alterations of corticospinal tract (CST) and medial lemniscus (ML) caused by TPTs and to demonstrate the application of HDFT in preoperative planning. METHODS: Three pediatric patients with TPTs were enrolled. CSTs and MLs were evaluated for displacement, infiltration, and disruption. The relationship of these tracts to tumors was identified and guided surgical planning. Literature was reviewed for publications on pediatric thalamic and TPTs that used diffusion imaging. RESULTS: Two patients had histologic diagnosis of pilocytic astrocytoma. One patient whose imaging suggested a low-grade glioma was managed conservatively. All tracts were displaced (1 CST anteriorly, 2 CSTs, 1 ML anteromedially, 1 ML medially, and 1 ML posteromedially). Literature review revealed 2 publications with 15 pilocytic astrocytoma cases, which investigated CST only. The condition of sensory pathway or anteromedial displacement of the CST in these tumors was not reported previously. CONCLUSIONS: Displacement patterns of the perilesional fiber bundles by TPTs are not predictable. Fiber tracking, preferably HDFT, should be part of preoperative planning to achieve maximal extent of resection for longer survival rates in this young group of patients, while preserving white matter tracts and thus quality of life.
[Mh] Termos MeSH primário: Astrocitoma/patologia
Neoplasias Encefálicas/patologia
[Mh] Termos MeSH secundário: Adolescente
Astrocitoma/cirurgia
Pedúnculo Cerebral/patologia
Pedúnculo Cerebral/cirurgia
Pré-Escolar
Imagem de Tensor de Difusão/métodos
Feminino
Seres Humanos
Leucoencefalopatias/patologia
Leucoencefalopatias/cirurgia
Imagem por Ressonância Magnética/métodos
Planejamento de Assistência ao Paciente
Cirurgia Assistida por Computador/métodos
Doenças Talâmicas/patologia
Doenças Talâmicas/cirurgia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE


  3 / 26 MEDLINE  
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[PMID]:27438376
[Au] Autor:Yuan W; Harpster K; Jones BV; Shimony JS; McKinstry RC; Weckherlin N; Powell SS; Barnard H; Engsberg J; Kadis DS; Dodd J; Altaye M; Limbrick DD; Holland SK; Simpson SM; Bidwell S; Mangano FT
[Ad] Endereço:Pediatric Neuroimaging Research Consortium, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, United States.
[Ti] Título:Changes of White Matter Diffusion Anisotropy in Response to a 6-Week iPad Application-Based Occupational Therapy Intervention in Children with Surgically Treated Hydrocephalus: A Pilot Study.
[So] Source:Neuropediatrics;47(5):336-40, 2016 Oct.
[Is] ISSN:1439-1899
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Objective Our aims were (1) to test whether diffusion tensor imaging (DTI) could detect underlying white matter (WM) changes after a 6-week iPad application-based occupational therapy (OT) intervention in children with surgically treated hydrocephalus (HCP); and (2) to explore the association between WM changes and performance outcomes. Methods Five children (age range: 6.05-9.10 years) with surgically treated HCP completed an intensive iPad-based OT intervention targeting common domains of long-term deficits in children with HCP. The intervention included 6 weekly sessions in an OT clinic supplementing home-based program (1 hour/day, 4 days/week). DTI and neuropsychological assessments were performed before and after the intervention. Observation After the therapy, significant increases in fractional anisotropy (FA) and/or decreases in radial diffusivity were found in extensive WM areas. All participants demonstrated an increased perceptual reasoning index (PRI, Wechsler Abbreviated Scale of Intelligence: 2nd edition, PRI gains = 14.20 ± 7.56, p = 0.014). A significant positive correlation was found between PRI increase and the increase of FA in the right posterior limb of the internal capsule and the right external capsule (both p < 0.05). Conclusion This study provides initial evidence of DTI's sensitivity to detect subtle WM changes associated with performance improvements in response to a 6-week OT intervention in children with HCP.
[Mh] Termos MeSH primário: Computadores de Mão
Hidrocefalia/reabilitação
Terapia Ocupacional
Substância Branca/diagnóstico por imagem
[Mh] Termos MeSH secundário: Anisotropia
Pedúnculo Cerebral/diagnóstico por imagem
Criança
Corpo Caloso/diagnóstico por imagem
Imagem de Difusão por Ressonância Magnética
Imagem de Tensor de Difusão
Cápsula Externa/diagnóstico por imagem
Feminino
Seres Humanos
Hidrocefalia/diagnóstico por imagem
Hidrocefalia/cirurgia
Cápsula Interna/diagnóstico por imagem
Estudos Longitudinais
Masculino
Testes Neuropsicológicos
Procedimentos Neurocirúrgicos
Projetos Piloto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1584938


  4 / 26 MEDLINE  
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[PMID]:27322806
[Au] Autor:Mullin JP; Soni P; Lee S; Jehi L; Naduvil Valappi AM; Bingaman W; Gonzalez-Martinez J
[Ad] Endereço:*Department of Neurosurgery, Epilepsy Center, and §Department of Neurology, Section of Pediatric Epilepsy, Neurological Institute, Cleveland Clinic, Cleveland, Ohio; ‡Case Western Reserve University Medical School, Cleveland, Ohio.
[Ti] Título:Volumetric Analysis of Cerebral Peduncles and Cerebellar Hemispheres for Predicting Hemiparesis After Hemispherectomy.
[So] Source:Neurosurgery;79(3):499-507, 2016 Sep.
[Is] ISSN:1524-4040
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In some cases of refractory epilepsy, hemispherectomy is the final invasive treatment option. However, predictors of postoperative hemiparesis in these patients have not been widely studied. OBJECTIVE: To investigate how the volumetric analysis of cerebral peduncles and cerebellar hemispheres in patients who have undergone hemispherectomy may determine prognostic implications for postoperative hemiparesis. METHODS: Twenty-two patients who underwent hemispherectomy at our institution were retrospectively included. Using iPlan/BrainLAB (BrainLAB, Feldkirchen, Germany) imaging software and a semiautomatic voxel-based segmentation method, we calculated the preoperative cerebral peduncle and cerebellar hemisphere volumes. Cerebral peduncle and cerebellar hemisphere ratios were compared between patients with worsened or unchanged/better hemiparesis postoperatively. RESULTS: The ratios of ipsilateral/contralateral cerebral peduncles (0.570 vs 0.828; P = .02) and contralateral/ipsilateral cerebellar hemispheres (0.885 vs 1.031; P = .009) were significantly lower in patients who had unchanged/improved hemiparesis postoperatively compared with patients who had worsened hemiparesis. Relative risk of worsening hemiparesis was significantly higher in patients with a cerebral peduncle ratio < 0.7 (relative risk, 4.3; P = .03) or a cerebellar ratio < 1.0 (relative risk, 6.4; P = .006). CONCLUSION: Although patients who undergo hemispherectomy are heterogeneous, we report a method of predicting postoperative hemiparesis using only standard volumetric magnetic resonance imaging. This information could be used in preoperative discussions with patients and families to help better understand that chance of retaining baseline motor function. ABBREVIATIONS: CST, corticospinal tractfMRI, functional magnetic resonance imagingTMS, transcranial magnetic stimulation.
[Mh] Termos MeSH primário: Cerebelo/patologia
Pedúnculo Cerebral/patologia
Hemisferectomia/efeitos adversos
Paresia/etiologia
[Mh] Termos MeSH secundário: Adulto
Cerebelo/diagnóstico por imagem
Pedúnculo Cerebral/diagnóstico por imagem
Feminino
Alemanha
Hemisferectomia/métodos
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Paresia/patologia
Período Pós-Operatório
Prognóstico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE
[do] DOI:10.1227/NEU.0000000000001307


  5 / 26 MEDLINE  
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[PMID]:27217504
[Au] Autor:Doughty C; Wang J; Feng W; Hackney D; Pani E; Schlaug G
[Ad] Endereço:From the Neuroimaging and Stroke Recovery Laboratory, Department of Neurology (C.D., J.W., W.F., E.P., G.S.) and Department of Radiology (D.H.), Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; and MUSC Stroke Center, Department of Neurology, Medical University of South C
[Ti] Título:Detection and Predictive Value of Fractional Anisotropy Changes of the Corticospinal Tract in the Acute Phase of a Stroke.
[So] Source:Stroke;47(6):1520-6, 2016 Jun.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: A decrease in fractional anisotropy (FA) of the ipsilesional corticospinal tract (CST) distal to stroke lesions in the subacute (eg, 30 days) and chronic phase has been correlated with poor motor outcomes, but it is unclear whether FA values obtained within the acute stroke phase (here defined as 80 hours after onset) can predict later outcome. METHODS: Fifty-eight patients underwent an assessment of motor impairment in the acute phase and at 3 months using the upper extremity Fugl-Meyer assessment. FA values, obtained within 80 hours after stroke onset, were determined in 2 regions of interest: cerebral peduncle and a stretch of the CST caudal to each stroke lesion (nearest-5-slices). RESULTS: The FA laterality index for the cerebral peduncle-regions of interest was a poor predictor of 3-month outcome (R(2)=0.044; P=0.137), whereas the slope over the FA laterality index of the nearest-5-slices showed a relatively weak but significant prediction (R(2)=0.11; P=0.022) with the affected side having lower FA values. Initial upper extremity Fugl-Meyer (R(2)=0.69; P<0.001) and the weighted CST lesion load (R(2)=0.71; P<0.001) were strong predictors of 3-month outcome. In multivariate analyses, controlling for initial upper extremity Fugl-Meyer, weighted CST lesion load, and days-of-therapy, neither the FA laterality index of the cerebral peduncle nor the slope over the FA laterality index of the nearest-5-slices significantly contributed to the prediction of 86% of the variance in the upper extremity Fugl-Meyer at 3 months. CONCLUSIONS: FA reductions of the CST can be detected near the ischemic lesion in the acute stroke phase, but offer minimal predictive value to motor outcomes at 3 months.
[Mh] Termos MeSH primário: Anisotropia
Tratos Piramidais/diagnóstico por imagem
Acidente Vascular Cerebral/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Isquemia Encefálica/diagnóstico por imagem
Pedúnculo Cerebral/diagnóstico por imagem
Imagem de Tensor de Difusão
Feminino
Lateralidade Funcional
Seres Humanos
Processamento de Imagem Assistida por Computador
Masculino
Meia-Idade
Valor Preditivo dos Testes
Estudos Prospectivos
Recuperação de Função Fisiológica
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160525
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.115.012088


  6 / 26 MEDLINE  
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[PMID]:27043125
[Au] Autor:Pascal de Raykeer R; Hoertel N; Manetti A; Rene M; Blumenstock Y; Schuster JP; Limosin F
[Ad] Endereço:Department of Psychiatry, Assistance Publique-Hôpitaux de Paris (APHP), Corentin Celton Hospital Issy-les-Moulineaux, France and Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France rachel.p.de.r@gmail.com Department of Psychiatry, APHP, Corentin Celton Hospital, Issy-les-Moulineaux, France and INSERM UMR 894, Psychiatry and Neurosciences Center, Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France Department of Psychiatry, APHP, Corentin Celton Hospital, Issy-les-Moulineaux, France and Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France Department of Psychiatry, APHP, Corentin Celton Hospital; and Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France Department of Psychiatry, APHP, Corentin Celton Hospital, Issy-les-Moulineaux, France and INSERM UMR 894, Psychiatry and Neurosciences Center, Paris Descartes University, PRES Sorbonne Paris Cité, Paris, France.
[Ti] Título:A Case of Chronic Peduncular Hallucinosis in a 90-Year-Old Woman Successfully Treated With Olanzapine.
[So] Source:J Clin Psychopharmacol;36(3):285-6, 2016 Jun.
[Is] ISSN:1533-712X
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antipsicóticos/uso terapêutico
Benzodiazepinas/uso terapêutico
Alucinações/diagnóstico
Alucinações/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso de 80 Anos ou mais
Pedúnculo Cerebral/patologia
Doença Crônica
Feminino
Seres Humanos
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; LETTER
[Nm] Nome de substância:
0 (Antipsychotic Agents); 12794-10-4 (Benzodiazepines); N7U69T4SZR (olanzapine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1097/JCP.0000000000000497


  7 / 26 MEDLINE  
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[PMID]:26215137
[Au] Autor:Chen W; Yi T; Chen Y; Zhang M; Wu Z; Wu Y; Chen B; Guo T; Wu C; Yang M; Chen X; Shi Y
[Ad] Endereço:Department of Neurology, Zhangzhou Affiliated Hospital of Fujian Medical University, Fujian, China. Electronic address: doctorwwenhuo@126.com.
[Ti] Título:Assessment of bilateral cerebral peduncular infarction: Magnetic resonance imaging, clinical features, and prognosis.
[So] Source:J Neurol Sci;357(1-2):131-5, 2015 Oct 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Bilateral cerebral peduncular infarction (BCPI) is an extremely rare neurological disorder, and related literature is scarce. This study investigated the clinical manifestations, magnetic resonance imaging (MRI) features and prognosis of BCPI. METHOD: We retrospectively reviewed the clinical features, MRI and magnetic resonance angiography manifestations, and prognosis of 14 patients with BCPI, confirmed by diffusion-weighted MRI from 5050 cerebral infarction patients at our medical center from January 2007 to June 2013. RESULT: Eleven of the 14 (78.6%) patients had quadriplegia and 9 (64.3%) had decreased consciousness. At the most severe stage, the National Institutes of Health Stroke Scale scores ranged from grades 4 to 26 (mean grade, 18.9). Eleven (78.6%) cases were caused by large artery atherosclerosis. Besides the bilateral cerebral peduncle, the pons (85.7%) and cerebellum (42.9%) were the other infarct locations. Twelve (85.7%) patients had vertebrobasilar artery occlusion or severe stenosis, and 12 (85.7%) did not have collateral patency of the posterior cerebral artery. Thirteen (92.9%) patients had poor prognosis and 9 of them died. OCCLUSION: BCPI is a very rare disorder and associated with severe vertebrobasilar artery stenosis or occlusion without collateral patency of the posterior communicating artery. It has a very poor prognosis.
[Mh] Termos MeSH primário: Infarto Cerebral/diagnóstico
Pedúnculo Cerebral/patologia
Angiografia por Ressonância Magnética
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Infarto Cerebral/epidemiologia
Feminino
Seres Humanos
Angiografia por Ressonância Magnética/métodos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Prognóstico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150919
[Lr] Data última revisão:
150919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150729
[St] Status:MEDLINE


  8 / 26 MEDLINE  
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[PMID]:26204292
[Au] Autor:Fatterpekar GM; Dietrich A; Pantano P; Saba L; Knopp EA; Piattella MC; Raz E
[Ad] Endereço:1 Department of Radiology, New York University School of Medicine, 660 First Ave, 7th Fl, New York, NY 10016.
[Ti] Título:Cerebral Peduncle Angle: An Objective Criterion for Assessing Progressive Supranuclear Palsy Richardson Syndrome.
[So] Source:AJR Am J Roentgenol;205(2):386-91, 2015 Aug.
[Is] ISSN:1546-3141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Several criteria for time-consuming volumetric measurements of progressive supranuclear palsy Richardson syndrome subtype (PSP-RS) have been proposed. These often require image reconstruction in different planes for proper assessment. The purpose of this study was to evaluate the cerebral peduncle angle as a simple and reproducible measure of midbrain atrophy in patients with PSP-RS. MATERIALS AND METHODS: The records of 15 patients with PSP-RS were retrospectively identified. The records of 31 age-matched healthy control subjects, 15 patients with multiple-system atrophy, and 22 patients with Parkinson disease were included for comparison. Two neuroradiologists individually assessed these studies for midbrain atrophy by evaluating the cerebral peduncle angle, that is, the angle between the two cerebral peduncles. RESULTS: The cerebral peduncle angle measurements were 62.1° (SD, 6.8°) in PSP-RS patients, 51.2° (SD, 10.1°) in healthy control subjects, 55.7° (SD, 11.6°) in patients with multiple-system atrophy, and 53.7° (SD, 8.5°) in patients with Parkinson disease. A statistically significant difference was found in the cerebral peduncle angle measurements (observer 1, p = 0.015; observer 2, p = 0.004) between the PSP-RS patients and the other subgroups. Bland-Altman analysis showed a bias of 0.6° (95% limits of agreement, 6.9°, -5.8°), and intraobserver variability analysis showed a bias of 0.5° (4.1°, -3°). CONCLUSION: The cerebral peduncle angle is a simple, easy-to-calculate, and reproducible measure of midbrain atrophy. It is a useful criterion for differentiating patients with PSP-RS from healthy persons and from patients with multiple-system atrophy or Parkinson disease.
[Mh] Termos MeSH primário: Pedúnculo Cerebral/patologia
Imagem por Ressonância Magnética/métodos
Paralisia Supranuclear Progressiva/patologia
[Mh] Termos MeSH secundário: Idoso
Estudos de Casos e Controles
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Masculino
Meia-Idade
Atrofia de Múltiplos Sistemas
Fenótipo
Reprodutibilidade dos Testes
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150724
[Lr] Data última revisão:
150724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:150724
[St] Status:MEDLINE
[do] DOI:10.2214/AJR.14.12724


  9 / 26 MEDLINE  
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[PMID]:26033583
[Au] Autor:Ublinskii MV; Semenova NA; Lukovkina OV; Sidorin SV; Lebedeva IS; Kaleda VG; Barkhatova AN; Akhadov TA
[Ad] Endereço:Research Institute of Urgent Children Surgery and Traumatology, Moscow, Russia.
[Ti] Título:Characteristics of Diffusion in the Corticospinal Tract of Patients with Early Stage of Schizophrenia: Diffusion Tensor Magnetic Resonance Imaging.
[So] Source:Bull Exp Biol Med;159(1):29-31, 2015 May.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Specific features of diffusion in the cerebral corticospinal tract of patients with early stages of schizophrenia were studied using methods of diffusion tensor magnetic-resonance imaging and magnetic resonance spectroscopy. A decrease in the coefficient of fractional anisotropy in the posterior limb of the internal capsule and an increase in diffusion coefficient in the radiate crown and motor cortex were observed. The results reflect different mechanisms of changes in water diffusion in various areas of the corticospinal tract: changes in nerve fiber microstructure in the internal capsule of the left hemisphere and a decrease in their density in the motor cortex and radiate crown.
[Mh] Termos MeSH primário: Imagem de Tensor de Difusão
Tratos Piramidais/metabolismo
Esquizofrenia/metabolismo
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anisotropia
Água Corporal
Pedúnculo Cerebral/metabolismo
Pedúnculo Cerebral/patologia
Difusão
Seres Humanos
Cápsula Interna/metabolismo
Cápsula Interna/patologia
Masculino
Bulbo/metabolismo
Bulbo/patologia
Córtex Motor/metabolismo
Córtex Motor/patologia
Fibras Nervosas/metabolismo
Fibras Nervosas/patologia
Tratos Piramidais/patologia
Esquizofrenia/patologia
Substância Branca/metabolismo
Substância Branca/patologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150609
[Lr] Data última revisão:
150609
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150603
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-015-2881-1


  10 / 26 MEDLINE  
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[PMID]:25873017
[Au] Autor:Segobin S; Ritz L; Lannuzel C; Boudehent C; Vabret F; Eustache F; Beaunieux H; Pitel AL
[Ad] Endereço:INSERM, Caen, France.
[Ti] Título:Integrity of white matter microstructure in alcoholics with and without Korsakoff's syndrome.
[So] Source:Hum Brain Mapp;36(7):2795-808, 2015 Jul.
[Is] ISSN:1097-0193
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Alcohol dependence results in two different clinical forms: "uncomplicated" alcoholism (UA) and Korsakoff's syndrome (KS). Certain brain networks are especially affected in UA and KS: the frontocerebellar circuit (FCC) and the Papez circuit (PC). Our aims were (1) to describe the profile of white matter (WM) microstructure in FCC and PC in the two clinical forms, (2) to identify those UA patients at risk of developing KS using their WM microstructural integrity as a biomarker. Tract-based spatial statistics and nonparametric voxel-based permutation tests were used to compare diffusion tensor imaging (DTI) data in 7 KS, 20 UA, and 14 healthy controls. The two patient groups were also pooled together and compared to controls. k-means classifications were then performed on mean fractional anisotropy values of significant clusters across all subjects for two fiber tracts from the FCC (the middle cerebellar peduncle and superior cerebellar peduncle) and two tracts from the PC (fornix and cingulum). We found graded effects of WM microstructural abnormalities in the PC of UA and KS. UA patients classified at risk of developing KS using fiber tracts of the PC from DTI data also had the lowest scores of episodic memory. That finding suggests that WM microstructure could be used as a biomarker for early detection of UA patients at risk of developing KS.
[Mh] Termos MeSH primário: Alcoolismo/patologia
Pedúnculo Cerebral/patologia
Imagem de Tensor de Difusão/métodos
Fórnice/patologia
Giro do Cíngulo/patologia
Síndrome de Korsakoff/patologia
Memória Episódica
Pedúnculo Cerebelar Médio/patologia
Substância Branca/patologia
[Mh] Termos MeSH secundário: Adulto
Biomarcadores
Análise por Conglomerados
Diagnóstico Precoce
Feminino
Seres Humanos
Síndrome de Korsakoff/diagnóstico
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150622
[Lr] Data última revisão:
150622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150416
[St] Status:MEDLINE
[do] DOI:10.1002/hbm.22808



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