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[PMID]:28193685
[Au] Autor:Schomers MR; Garagnani M; Pulvermüller F
[Ad] Endereço:Brain Language Laboratory, Freie Universität Berlin, 14195 Berlin, Germany, malte2011@cantab.net.
[Ti] Título:Neurocomputational Consequences of Evolutionary Connectivity Changes in Perisylvian Language Cortex.
[So] Source:J Neurosci;37(11):3045-3055, 2017 Mar 15.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The human brain sets itself apart from that of its primate relatives by specific neuroanatomical features, especially the strong linkage of left perisylvian language areas (frontal and temporal cortex) by way of the arcuate fasciculus (AF). AF connectivity has been shown to correlate with verbal working memory-a specifically human trait providing the foundation for language abilities-but a mechanistic explanation of any related causal link between anatomical structure and cognitive function is still missing. Here, we provide a possible explanation and link, by using neurocomputational simulations in neuroanatomically structured models of the perisylvian language cortex. We compare networks mimicking key features of cortical connectivity in monkeys and humans, specifically the presence of relatively stronger higher-order "jumping links" between nonadjacent perisylvian cortical areas in the latter, and demonstrate that the emergence of working memory for syllables and word forms is a functional consequence of this structural evolutionary change. We also show that a mere increase of learning time is not sufficient, but that this specific structural feature, which entails higher connectivity degree of relevant areas and shorter sensorimotor path length, is crucial. These results offer a better understanding of specifically human anatomical features underlying the language faculty and their evolutionary selection advantage. Why do humans have superior language abilities compared to primates? Recently, a uniquely human neuroanatomical feature has been demonstrated in the strength of the arcuate fasciculus (AF), a fiber pathway interlinking the left-hemispheric language areas. Although AF anatomy has been related to linguistic skills, an explanation of how this fiber bundle may support language abilities is still missing. We use neuroanatomically structured computational models to investigate the consequences of evolutionary changes in language area connectivity and demonstrate that the human-specific higher connectivity degree and comparatively shorter sensorimotor path length implicated by the AF entail emergence of verbal working memory, a prerequisite for language learning. These results offer a better understanding of specifically human anatomical features for language and their evolutionary selection advantage.
[Mh] Termos MeSH primário: Evolução Biológica
Córtex Cerebral/fisiologia
Linguagem
Modelos Genéticos
Modelos Neurológicos
Plasticidade Neuronal/genética
[Mh] Termos MeSH secundário: Animais
Aqueduto do Mesencéfalo/fisiologia
Simulação por Computador
Conectoma/métodos
Haplorrinos
Seres Humanos
Macaca
Pan troglodytes
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.2693-16.2017


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[PMID]:28034816
[Au] Autor:Oertel J; Vulcu S; Eickele L; Wagner W; Cinalli G; Rediker J
[Ad] Endereço:Department of Neurosurgery, Saarland University Medical Center, Homburg/Saar, Germany. Electronic address: oertelj@freenet.de.
[Ti] Título:Long-Term Follow-Up of Repeat Endoscopic Third Ventriculostomy in Obstructive Hydrocephalus.
[So] Source:World Neurosurg;99:556-565, 2017 Mar.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Endoscopic third ventriculostomy (ETV) is a safe and less-invasive treatment strategy for patients with obstructive hydrocephalus and provides excellent outcome. Nevertheless, repeat ETV in cases of ETV failure is a controversial issue. METHODS: Between 1993 and 1999, 113 patients underwent a total of 126 ETVs at the Department of Neurosurgery, Mainz University Hospital. Obstructive hydrocephalus was the causative pathology in all cases. A very long-term follow-up of up to 16 years could be achieved. All medical reports of patients who received ETV were reviewed and analyzed with focus on ETV failure with following repeat ETV and its initial as well as very long-term success. RESULTS: Thirty-one events of ETV failure occurred during the follow-up period. Thirteen patients underwent repeat ETV: 3 patients during the first 3 months (early repeat ETV), the other 10 patients after 7-78 months (late repeat ETV, mean 33 months). All repeat ETV were performed without complications. Follow-up evaluation after successful repeat ETV ranged from <1 month up to 14 years (mean 7 years). Of the 3 early revisions, 2 failed and 1 other patient died during follow-up whereas only 2 of the late repeat ETV failed. Very long-term success rate of late repeat ETV up to 14 years yielded 80%. CONCLUSIONS: Repeat ETV in cases of late ETV failures represents an excellent option for cerebrospinal fluid circulation restoration up to 14 years of follow-up. Repeat ETV in early ETV failure in contrast is not favored by the performing surgeons; and factors of ETV failure should be analyzed very carefully before a decision for repeat ETV is made.
[Mh] Termos MeSH primário: Hidrocefalia/cirurgia
Neuroendoscopia
Terceiro Ventrículo/cirurgia
Ventriculostomia
[Mh] Termos MeSH secundário: Adolescente
Neoplasias do Sistema Nervoso Central/complicações
Aqueduto do Mesencéfalo
Criança
Pré-Escolar
Constrição Patológica
Cistos/complicações
Feminino
Seguimentos
Seres Humanos
Hidrocefalia/etiologia
Lactente
Hemorragias Intracranianas/complicações
Masculino
Reoperação
Estudos Retrospectivos
Falha de Tratamento
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


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[PMID]:27890756
[Au] Autor:Feletti A; Dimitriadis S; Pavesi G
[Ad] Endereço:Department of Neurosurgery, NOCSAE Hospital of Modena, Modena, Italy. Electronic address: a.feletti@ausl.mo.it.
[Ti] Título:Cavernous Angioma of the Cerebral Aqueduct.
[So] Source:World Neurosurg;98:876.e15-876.e22, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Among the rare intraventricular cavernomas, purely intra-aqueductal cavernomas are exceptionally rare. CASE DESCRIPTION: A 62-year-old patient presented with progressive headache, memory loss, gait instability, and urinary incontinence. Magnetic resonance imaging showed the presence of a mass lesion located in the lumen of the cerebral aqueduct, associated with triventricular hydrocephalus. CONCLUSIONS: We discuss the rationale that led us to treat hydrocephalus with neuroendoscopy, which offered the possibility to directly inspect the intra-aqueductal lesion, make the diagnosis of cavernoma, and treat symptoms resulting from hydrocephalus without increasing the risk of bleeding.
[Mh] Termos MeSH primário: Aqueduto do Mesencéfalo/patologia
Aqueduto do Mesencéfalo/cirurgia
Neoplasias do Ventrículo Cerebral/patologia
Neoplasias do Ventrículo Cerebral/cirurgia
Hemangioma Cavernoso/patologia
Hemangioma Cavernoso/cirurgia
[Mh] Termos MeSH secundário: Aqueduto do Mesencéfalo/diagnóstico por imagem
Neoplasias do Ventrículo Cerebral/diagnóstico por imagem
Feminino
Hemangioma Cavernoso/diagnóstico por imagem
Seres Humanos
Hidrocefalia/diagnóstico por imagem
Hidrocefalia/etiologia
Hidrocefalia/cirurgia
Imagem por Ressonância Magnética
Meia-Idade
Neuroendoscopia/métodos
Procedimentos Neurocirúrgicos/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE


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[PMID]:27873519
[Au] Autor:Nam TK; Park YS; Byun JS; Park SW; Kwon JT
[Ad] Endereço:Department of Neurosurgery, Chung-Ang University Hospital, Seoul, Korea.
[Ti] Título:Use of Three-Dimensional Curved-Multiplanar Reconstruction Images for Sylvian Dissection in Microsurgery of Middle Cerebral Artery Aneurysms.
[So] Source:Yonsei Med J;58(1):241-247, 2017 Jan.
[Is] ISSN:1976-2437
[Cp] País de publicação:Korea (South)
[La] Idioma:eng
[Ab] Resumo:PURPOSE: The purpose of this study was to introduce a method of using three-dimensional (3D) curved-multiplanar reconstruction (MPR) images for sylvian dissection during microsurgical treatment of middle cerebral artery (MCA) aneurysms. MATERIALS AND METHODS: Forty-nine patients who had undergone surgery for MCA aneurysms were enrolled. We obtained the 3D curved-MPR images along the sphenoid ridge using OsiriX MD™ imaging software, compared sylvian dissection time according to several 3D MPR image factors, and investigated the correlations between these images and intraoperative findings. RESULTS: Utilizing preoperative information of the sylvian fissure (SF) and peri-aneurysmal space on 3D curved-MPR images, we could predict the feasibility of sylvian dissection for a safe surgery. 3D curved-MPR images showed several features: first, perpendicular images to the sylvian surface in the same orientation as the surgeon's view; second, simultaneous visualization of the brain cortex, vessels, and cisternal space; and third, more accurate measurement of various parameters, such as depth of the MCA from the sylvian surface and the location and width of the SFs. CONCLUSION: In addition to conventional image studies, 3D curved-MPR images seem to provide useful information for Sylvian dissection in the microsurgical treatment of MCA aneurysms.
[Mh] Termos MeSH primário: Aqueduto do Mesencéfalo/cirurgia
Imagem Tridimensional/métodos
Aneurisma Intracraniano/cirurgia
Microdissecção/métodos
Artéria Cerebral Média/cirurgia
[Mh] Termos MeSH secundário: Adulto
Idoso
Feminino
Seres Humanos
Masculino
Microcirurgia/métodos
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE
[do] DOI:10.3349/ymj.2017.58.1.241


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[PMID]:27863121
[Au] Autor:Oner Z; SagÑ–r Kahraman A; Kose E; Oner S; KavaklÑ– A; Cay M; Ozbag D
[Ad] Endereço:Department of Anatomy, Karabük University, Karabük, Turkey.
[Ti] Título:Quantitative Evaluation of Normal Aqueductal Cerebrospinal Fluid Flow Using Phase-Contrast Cine MRI According to Age and Sex.
[So] Source:Anat Rec (Hoboken);300(3):549-555, 2017 Mar.
[Is] ISSN:1932-8494
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of this study was cerebrospinal fluid (CSF) flow quantification in the cerebral aqueduct using phase-contrast cine magnetic resonance imaging (PCC-MRI) according to both sexes and three different age groups to obtain normative data. Seventy two volunteers with no cerebral pathology were included in this study. Subjects were divided into three age groups: 20-34 years, 35-49 years, and 50-65 years including equal gender groups. CSF flow's quantitatively evaluation was performed with images that were obtained by 1.5 T Magnetic Resonance (MR) unit from cerebral aqueduct level on the semi-axial plan. Between groups, peak velocity (cm sec ), average velocity (cm/s), forward volume (mL), reverse volume (mL), net forward volume (mL), and average flow over range (ml/min) values of current flowing through aqueduct and average aqueductal areas were compared. There were no statistically significant differences in CSF flow parameters among different age groups and between sexes (P > 0.05). There was a statistically significant difference in average cerebral aqueduct area between the age group of 50-65 years and the other age groups (P = 0.002). The average aqueductal area was higher in the age group of 50-65 years. Normal aqueductal CSF flow parameters evaluated with PCC-MRI don't show a significant difference by age and sex. We have achieved the lower and upper values of these parameters would be useful in future clinical studies. The size of aqueductal area may also be explained by atrophy-dependent ventricular system dilatation in the elderly. Anat Rec, 300:549-555, 2017. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Aqueduto do Mesencéfalo/diagnóstico por imagem
Líquido Cefalorraquidiano/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Fatores Etários
Idoso
Feminino
Seres Humanos
Imagem Cinética por Ressonância Magnética/métodos
Masculino
Meia-Idade
Fatores Sexuais
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1002/ar.23514


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[PMID]:27847269
[Au] Autor:Zhang Y; Hu Q; Xue H; Zhang M; Shen J; Deng L; Liu Q; Li G
[Ad] Endereço:Neurosurgery Department of Qilu Hospital Affiliated to Shandong University, Jinan, Shandong Province, China.
[Ti] Título:Intrasylvian/Intracerebral Hematomas Associated with Ruptured Middle Cerebral Artery Aneurysms: A Single-Center Series and Literature Review.
[So] Source:World Neurosurg;98:432-437, 2017 Feb.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Ruptured middle cerebral artery (MCA) aneurysms usually lead to subarachnoid hemorrhage (SAH), and several cases have shown concomitant intrasylvian or intracerebral hematomas. The objective of this study was to compare the clinical and radiographic characteristics with their different outcomes. METHODS: The charts of 30 consecutive patients with ruptured MCA aneurysm-related intracranial hematoma were retrospectively reviewed. These patients were dichotomized into an intrasylvian hematoma (ISH) group and an intracerebral hematoma (ICH) group by the presence of intrahematomal contrast-enhancing vessel; for patients under open surgery, hematoma type was further confirmed by intraoperative observation. The characteristics were compared between these 2 groups (ie, age, gender, history of hypertension, history of smoking, systolic pressure at admission, hematoma volume, size and side of aneurysms, the angle between the pointing direction of the aneurysm and the MCA trunk [denoted as α], middle line shifting, treatment modality, and outcome). All the angles are measured in the anterior-posterior projection. RESULTS: In our series, only hematoma volume, the angle α, and the middle line shift showed statistical significance regarding prognosis between 2 hematoma groups. An angle α between 109.0°and 216.0° is associated with ISH, whereas aneurysm with an angle beyond this range indicates ICH. In our series, patients in the ICH group had a larger hematoma volume compared with the ISH patients (33.3 ± 17.6 vs. 11.5 ± 10.5; P = 0.002). There exists no statistical difference regarding prognosis between these 2 groups, even although there is a trend toward worse recovery for patients in the ISH group (Glasgow Outcome Scale score, 3.0 ± 1.3 vs. 3.8 ± 1.9; P = 0.07). CONCLUSIONS: In our series, the prognosis of patients with ICH was worse than that of patients with ISH. Early discrimination of these 2 types of hematoma helps to predict future outcome; an angle (between the pointing direction of aneurysm and the MCA trunk) between 109.0°and 216.0° is associated with ISH, whereas aneurysm with an angle beyond this range suggests ICH.
[Mh] Termos MeSH primário: Aneurisma Roto/diagnóstico por imagem
Aqueduto do Mesencéfalo/diagnóstico por imagem
Hematoma Epidural Craniano/diagnóstico por imagem
Aneurisma Intracraniano/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Aneurisma Roto/epidemiologia
Aneurisma Roto/cirurgia
Aqueduto do Mesencéfalo/cirurgia
Hematoma Epidural Craniano/epidemiologia
Hematoma Epidural Craniano/cirurgia
Seres Humanos
Aneurisma Intracraniano/epidemiologia
Aneurisma Intracraniano/cirurgia
Meia-Idade
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE


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[PMID]:27388230
[Au] Autor:Qvarlander S; Ambarki K; Wåhlin A; Jacobsson J; Birgander R; Malm J; Eklund A
[Ad] Endereço:Department of Radiation Sciences, Umeå University, Umeå, Sweden.
[Ti] Título:Cerebrospinal fluid and blood flow patterns in idiopathic normal pressure hydrocephalus.
[So] Source:Acta Neurol Scand;135(5):576-584, 2017 May.
[Is] ISSN:1600-0404
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Increased aqueduct cerebrospinal fluid (CSF) flow pulsatility and, recently, a reversed CSF flow in the aqueduct have been suggested as hallmarks of idiopathic normal pressure hydrocephalus (INPH). However, these findings have not been adequately confirmed. Our objective was to investigate the flow of blood and CSF in INPH, as compared to healthy elderly, in order to clarify which flow parameters are related to the INPH pathophysiology. MATERIALS AND METHODS: Sixteen INPH patients (73 years) and 35 healthy subjects (72 years) underwent phase-contrast magnetic resonance imaging (MRI). Measurements included aqueduct and cervical CSF flow, total arterial inflow (tCBF; i.e. carotid + vertebral arteries), and internal jugular vein flow. Flow pulsatility, net flow, and flow delays were compared (multiple linear regression, correcting for sex and age). RESULTS: Aqueduct stroke volume was higher in INPH than healthy (148±95 vs 90±50 mL, P<.05). Net aqueduct CSF flow was similar in magnitude and direction. The cervical CSF stroke volume was lower (P<.05). The internal carotid artery net flow was lower in INPH (P<.05), although tCBF was not. No differences were found in internal jugular vein flow or flow delays. CONCLUSIONS: The typical flow of blood and CSF in INPH was mainly characterized by increased CSF pulsatility in the aqueduct and reduced cervical CSF pulsatility. The direction of mean net aqueduct CSF flow was from the third to the fourth ventricle. Our findings may reflect the altered distribution of intracranial CSF volume in INPH, although the causality of these relationships is unclear.
[Mh] Termos MeSH primário: Velocidade do Fluxo Sanguíneo/fisiologia
Aqueduto do Mesencéfalo/diagnóstico por imagem
Aqueduto do Mesencéfalo/fisiologia
Líquido Cefalorraquidiano/fisiologia
Hidrocefalia de Pressão Normal/diagnóstico por imagem
Hidrocefalia de Pressão Normal/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Ventrículos Cerebrais/fisiopatologia
Feminino
Seres Humanos
Imagem por Ressonância Magnética/métodos
Masculino
Meia-Idade
Fluxo Pulsátil/fisiologia
Estudos Retrospectivos
Método Simples-Cego
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160709
[St] Status:MEDLINE
[do] DOI:10.1111/ane.12636


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[PMID]:27730385
[Au] Autor:González-Martínez EL; Santamarta D
[Ad] Endereço:Department of Neurosurgery, University Hospital of Álava, Vitoria, Spain. emilio.gonzalez.martinez@gmail.com.
[Ti] Título:Does aqueductal stenosis influence the lumbar infusion test in normal-pressure hydrocephalus?
[So] Source:Acta Neurochir (Wien);158(12):2305-2310, 2016 Dec.
[Is] ISSN:0942-0940
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Late-onset idiopathic aqueductal stenosis may present with clinical features indistinct from idiopathic normal-pressure hydrocephalus (NPH). Moreover, aqueductal stenosis (AS) is not always detected by conventional magnetic resonance imaging (MRI). The aim of this study was to compare the hydrodynamic pattern among NPH patients according to the patency of the aqueduct. METHODS: Fifty-six consecutive lumbar infusion tests were performed in patients with NPH syndrome. Precipitating causes of hydrocephalus were excluded, and aqueductal patency was examined through high-resolution, T2-weighted 3D MRI. Patients were classified into two groups: non-patent aqueduct and patent aqueduct. Mean values of pressure and pulse amplitude were obtained from basal and plateau stages of infusion studies. RESULTS: Twelve of 56 patients with NPH-like symptoms presented with morphological AS (21.4 %). Patent aqueduct and non-patent aqueduct groups had similar values of mean opening lumbar pressure (8.2 vs. 8.1 mmHg), and mean opening pulse amplitude (3.1 vs. 2.9 mmHg). Mean pressure in the plateau stage (28.6 vs. 23.2 mmHg), and mean pulse amplitude in the plateau stage (12.5 vs. 10.6 mmHg) were higher in the patent aqueduct group. These differences were not statistically significant. Only Rout was significantly higher in the patent aqueduct group (13.6 vs. 10.1 mmHg/ml/min). One-third of NPH patients with AS presented Rout >12 mmHg/ml/min. CONCLUSIONS: No differences in mean pressure or pulse amplitude during basal and plateau epochs of the lumbar infusion test in NPH patients were detected, regardless of aqueductal patency. However, Rout was significantly higher in patients with patent aqueduct.
[Mh] Termos MeSH primário: Aqueduto do Mesencéfalo/anormalidades
Doenças Genéticas Ligadas ao Cromossomo X/diagnóstico
Hidrocefalia de Pressão Normal/diagnóstico
Hidrocefalia/diagnóstico
[Mh] Termos MeSH secundário: Adulto
Ventrículos Cerebrais/diagnóstico por imagem
Ventrículos Cerebrais/patologia
Diagnóstico Diferencial
Feminino
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161013
[St] Status:MEDLINE


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[PMID]:27684996
[Au] Autor:Öztürk M; Sigirci A; Ünlü S
[Ad] Endereço:Diyarbakir Children's Hospital, 21100, Diyarbakir, Turkey. Electronic address: drmehmet2121@gmail.com.
[Ti] Título:Evaluation of aqueductal cerebrospinal fluid flow dynamics with phase-contrast cine magnetic resonance imaging in normal pediatric cases.
[So] Source:Clin Imaging;40(6):1286-1290, 2016 Nov - Dec.
[Is] ISSN:1873-4499
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: This study aimed to determine differences according to age groups and gender in the parameters of aqueductal cerebrospinal fluid (CSF) flow in childhood using phase-contrast cine magnetic resonance imaging (MRI) method. MATERIALS AND METHODS: This prospective study included 47 boys and 36 girls for a total of 83 healthy children. The cases were divided into three groups depending on age as infants (1-12 months), children (12-120 months), and adolescents (120-204 months). To quantitatively evaluate CSF flow, images in the transverse plane were taken at the cerebral aqueduct level using the phase-contrast MR angiography technique in a 1.5-T MR unit. Peak and average velocity (cm/s), cranial direction, caudal direction and net volume (ml), and aqueduct area (mm ) were calculated. To assess differences between the groups, a one-way analysis of variance and least significant difference tests were used. RESULTS: A statistically significant difference was determined between children and adolescents in peak velocity and caudal direction volume (P=.012 and P=.039, respectively) and between infants and children in cranial direction volume (P=.036). Peak velocity, cranial direction, and net volume were higher in boys (P=.050, P=.016, and P=.029, respectively). There were no differences by age and gender in the aqueduct area. CONCLUSION: In conclusion, this study determined the normal values for the CSF flow parameters of velocity, volume, and aqueduct area using phase-contrast MRI in healthy children. Velocity and volume parameters varied according to age and sex and were not affected in the aqueductal area.
[Mh] Termos MeSH primário: Aqueduto do Mesencéfalo/diagnóstico por imagem
Aqueduto do Mesencéfalo/fisiologia
Líquido Cefalorraquidiano/fisiologia
Imagem Cinética por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adolescente
Criança
Pré-Escolar
Meios de Contraste
Feminino
Seres Humanos
Lactente
Imagem por Ressonância Magnética/métodos
Masculino
Estudos Prospectivos
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160930
[St] Status:MEDLINE


  10 / 1332 MEDLINE  
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[PMID]:27601434
[Au] Autor:Pardini M; Sudre CH; Prados F; Yaldizli Ö; Sethi V; Muhlert N; Samson RS; van de Pavert SH; Cardoso MJ; Ourselin S; Gandini Wheeler-Kingshott CA; Miller DH; Chard DT
[Ad] Endereço:Department of Neuroinflammation, NMR Research Unit, Queen Square MS Centre, UCL Institute of Neurology, London, UK Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa and IRCCS AOU San Martino-IST, Genoa, Italy.
[Ti] Título:Relationship of grey and white matter abnormalities with distance from the surface of the brain in multiple sclerosis.
[So] Source:J Neurol Neurosurg Psychiatry;87(11):1212-1217, 2016 Nov.
[Is] ISSN:1468-330X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To assess the association between proximity to the inner (ventricular and aqueductal) and outer (pial) surfaces of the brain and the distribution of normal appearing white matter (NAWM) and grey matter (GM) abnormalities, and white matter (WM) lesions, in multiple sclerosis (MS). METHODS: 67 people with relapse-onset MS and 30 healthy controls were included in the study. Volumetric T1 images and high-resolution (1 mm ) magnetisation transfer ratio (MTR) images were acquired and segmented into 12 bands between the inner and outer surfaces of the brain. The first and last bands were discarded to limit partial volume effects with cerebrospinal fluid. MTR values were computed for all bands in supratentorial NAWM, cerebellar NAWM and brainstem NA tissue, and deep and cortical GM. Band WM lesion volumes were also measured. RESULTS: Proximity to the ventricular surfaces was associated with progressively lower MTR values in the MS group but not in controls in supratentorial and cerebellar NAWM, brainstem NA and in deep and cortical GM. The density of WM lesions was associated with proximity to the ventricles only in the supratentorial compartment, and no link was found with distance from the pial surfaces. CONCLUSIONS: In MS, MTR abnormalities in NAWM and GM are related to distance from the inner and outer surfaces of the brain, and this suggests that there is a common factor underlying their spatial distribution. A similar pattern was not found for WM lesions, raising the possibility that different factors promote their formation.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Encéfalo/patologia
Tomografia Computadorizada de Feixe Cônico/métodos
Substância Cinzenta/diagnóstico por imagem
Substância Cinzenta/patologia
Imagem por Ressonância Magnética/métodos
Esclerose Múltipla Recidivante-Remitente/diagnóstico por imagem
Esclerose Múltipla Recidivante-Remitente/patologia
Substância Branca/diagnóstico por imagem
Substância Branca/patologia
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico
Tronco Encefálico/diagnóstico por imagem
Tronco Encefálico/patologia
Cerebelo/diagnóstico por imagem
Cerebelo/patologia
Aqueduto do Mesencéfalo/diagnóstico por imagem
Córtex Cerebral/diagnóstico por imagem
Córtex Cerebral/patologia
Ventrículos Cerebrais/diagnóstico por imagem
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Masculino
Meia-Idade
Pia-Máter/diagnóstico por imagem
Pia-Máter/patologia
Valores de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171114
[Lr] Data última revisão:
171114
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE
[do] DOI:10.1136/jnnp-2016-313979



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