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[PMID]:28777035
[Au] Autor:Roland JL; Price RL; Kamath AA; Akbari SH; Leuthardt EC; Miller BA; Smyth MD
[Ad] Endereço:Departments of 1 Neurological Surgery.
[Ti] Título:Hydrocephalus presenting as idiopathic aqueductal stenosis with subsequent development of obstructive tumor: report of 2 cases demonstrating the importance of serial imaging.
[So] Source:J Neurosurg Pediatr;20(4):329-333, 2017 Oct.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The authors describe 2 cases of triventricular hydrocephalus initially presenting as aqueductal stenosis that subsequently developed tumors of the pineal and tectal region. The first case resembled late-onset idiopathic aqueductal stenosis on serial imaging. Subsequent imaging revealed a new tumor in the pineal region causing mass effect on the midbrain. The second case presented in a more typical pattern of aqueductal stenosis during infancy. On delayed follow-up imaging, an enlarging tectal mass was discovered. In both cases hydrocephalus was successfully treated by cerebrospinal fluid diversion prior to tumor presentation. The differential diagnoses, diagnostic testing, and treatment course for these unusual cases are discussed. The importance of follow-up MRI in cases of idiopathic aqueductal stenosis is emphasized by these exemplar cases.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/etiologia
Hidrocefalia/complicações
Hidrocefalia/cirurgia
Glândula Pineal/patologia
Terceiro Ventrículo/cirurgia
Ventriculostomia/métodos
[Mh] Termos MeSH secundário: Criança
Progressão da Doença
Feminino
Seguimentos
Seres Humanos
Hidrocefalia/diagnóstico por imagem
Lactente
Imagem por Ressonância Magnética
Masculino
Glândula Pineal/diagnóstico por imagem
Pinealoma/diagnóstico por imagem
Pinealoma/etiologia
Teto do Mesencéfalo/diagnóstico por imagem
Teto do Mesencéfalo/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170805
[St] Status:MEDLINE
[do] DOI:10.3171/2017.5.PEDS1779


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[PMID]:28183840
[Au] Autor:Aboian MS; Solomon DA; Felton E; Mabray MC; Villanueva-Meyer JE; Mueller S; Cha S
[Ad] Endereço:From the Department of Radiology (M.S.A., E.F., M.C.M., J.E.V.-M., S.C.).
[Ti] Título:Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation.
[So] Source:AJNR Am J Neuroradiol;38(4):795-800, 2017 Apr.
[Is] ISSN:1936-959X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: The 2016 World Health Organization Classification of Tumors of the Central Nervous System includes "diffuse midline glioma with histone H3 K27M mutation" as a new diagnostic entity. We describe the MR imaging characteristics of this new tumor entity in pediatric patients. MATERIALS AND METHODS: We retrospectively reviewed imaging features of pediatric patients with midline gliomas with or without the histone H3 K27 mutation. We evaluated the imaging features of these tumors on the basis of location, enhancement pattern, and necrosis. RESULTS: Among 33 patients with diffuse midline gliomas, histone H3 K27M mutation was present in 24 patients (72.7%) and absent in 9 (27.3%). Of the tumors, 27.3% ( = 9) were located in the thalamus; 42.4% ( = 14), in the pons; 15% ( = 5), within the vermis/fourth ventricle; and 6% ( = 2), in the spinal cord. The radiographic features of diffuse midline gliomas with histone H3 K27M mutation were highly variable, ranging from expansile masses without enhancement or necrosis with large areas of surrounding infiltrative growth to peripherally enhancing masses with central necrosis with significant mass effect but little surrounding T2/FLAIR hyperintensity. When we compared diffuse midline gliomas on the basis of the presence or absence of histone H3 K27M mutation, there was no significant correlation between enhancement or border characteristics, infiltrative appearance, or presence of edema. CONCLUSIONS: We describe, for the first time, the MR imaging features of pediatric diffuse midline gliomas with histone H3 K27M mutation. Similar to the heterogeneous histologic features among these tumors, they also have a diverse imaging appearance without distinguishing features from histone H3 wildtype diffuse gliomas.
[Mh] Termos MeSH primário: Neoplasias do Sistema Nervoso Central/diagnóstico por imagem
Neoplasias do Sistema Nervoso Central/genética
Glioma/diagnóstico por imagem
Glioma/genética
Histonas/genética
[Mh] Termos MeSH secundário: Adolescente
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/genética
Criança
Pré-Escolar
Fossa Craniana Posterior/diagnóstico por imagem
Feminino
Seres Humanos
Processamento de Imagem Assistida por Computador
Lactente
Imagem por Ressonância Magnética
Masculino
Mutação
Neuroimagem
Estudos Retrospectivos
Neoplasias da Medula Espinal/diagnóstico por imagem
Neoplasias da Medula Espinal/genética
Teto do Mesencéfalo/diagnóstico por imagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Histones)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170211
[St] Status:MEDLINE
[do] DOI:10.3174/ajnr.A5076


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[PMID]:27394688
[Au] Autor:Baginskas A; Kuras A
[Ad] Endereço:Department of Physics, Mathematics and Biophysics, Medical Academy, Lithuanian University of Health Sciences, Eiveniu 4, Kaunas LT 50161, Lithuania. Electronic address: Armuntas.baginskas@lsmuni.lt.
[Ti] Título:Retinal co-mediator acetylcholine evokes muscarinic inhibition of recurrent excitation in frog tectum column.
[So] Source:Neurosci Lett;629:137-142, 2016 08 26.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Acetylcholine receptors contribute to the control of neuronal and neuronal network activity from insects to humans. We have investigated the action of acetylcholine receptors in the optic tectum of Rana temporaria (common frog). Our previous studies have demonstrated that acetylcholine activates presynaptic nicotinic receptors, when released into the frog optic tectum as a co-mediator during firing of a single retinal ganglion cell, and causes: a) potentiation of retinotectal synaptic transmission, and b) facilitation of transition of the tectum column to a higher level of activity. In the present study we have shown that endogenous acetylcholine also activates muscarinic receptors, leading to a delayed inhibition of recurrent excitatory synaptic transmission in the tectum column. The delay of muscarinic inhibition was evaluated to be of ∼80ms, with an extent of inhibition of ∼2 times. The inhibition of the recurrent excitation determines transition of the tectum column back to its resting state, giving a functional sense for the inhibition.
[Mh] Termos MeSH primário: Acetilcolina/fisiologia
Receptores Muscarínicos/fisiologia
Células Ganglionares da Retina/fisiologia
Transmissão Sináptica
Teto do Mesencéfalo/fisiologia
[Mh] Termos MeSH secundário: Animais
Atropina/administração & dosagem
Estimulação Elétrica
Modelos Neurológicos
Antagonistas Muscarínicos/administração & dosagem
Inibição Neural
Rana temporaria
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Muscarinic Antagonists); 0 (Receptors, Muscarinic); 7C0697DR9I (Atropine); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160711
[St] Status:MEDLINE


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[PMID]:27111331
[Au] Autor:Dubinski D; Mittelbronn M; Marquardt G; Tews DS; Noack A; Behmanesh B; Seifert V; Freiman TM
[Ad] Endereço:Department of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
[Ti] Título:Immature teratoma of the tectum mesencephali with histopathological detection of rudimentary eye anlage in a 3-year-old boy: Report of a rare case.
[So] Source:Neuropathology;36(6):556-560, 2016 Dec.
[Is] ISSN:1440-1789
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Intracranial teratoma is a rare neoplasm derived from omnipotent germinal cells that can contain mesoderm, endoderm and/or ectoderm layer tissue. Histologically teratomas are characterized by abnormal structures like teeth or bone that can be further subdivided into mature and immature according to the presence of incompletely differentiated tissue. Characteristic intracranial teratomas are space-occupying lesions in the pineal region and often present with hydrocephalic symptoms due to aqueduct stenosis. A 3-year-old boy presented with a peracute hemiparesis, fatigue and speech deficit. MRI diagnostics showed a cystic, partially solid, inhomogeneous contrast-enhancing formation at the top of the tectum mesencephali with consecutive aqueduct compression. The patient underwent a sub-occipital craniotomy via a supracerebellar approach and complete resection was achieved. The histopathological examination mainly showed mature tissue of ectodermal, mesodermal and endodermal origin. However, small areas of undifferentiated neuroectodermal tissue within an optic vesicle formation were detected, leading to the diagnosis of an immature teratoma. In due course, the patient was discharged in good health without neurological deficits. To our knowledge, optic vesicle-containing intracranial germ cell tumors are extremely rare. Here we report a unique case with immature neuroectodermal tissue within an optic vesicle formation in an otherwise mature teratoma.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/patologia
Olho/patologia
Teto do Mesencéfalo/patologia
Teratoma/patologia
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/diagnóstico por imagem
Pré-Escolar
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Teto do Mesencéfalo/diagnóstico por imagem
Teratoma/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE
[do] DOI:10.1111/neup.12306


  5 / 1224 MEDLINE  
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[PMID]:27098691
[Au] Autor:Orton LD; Papasavvas CA; Rees A
[Ad] Endereço:Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE2 4HH, United Kingdom.
[Ti] Título:Commissural Gain Control Enhances the Midbrain Representation of Sound Location.
[So] Source:J Neurosci;36(16):4470-81, 2016 Apr 20.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Accurate localization of sound sources is essential for survival behavior in many species. The inferior colliculi (ICs) are the first point in the auditory pathway where cues used to locate sounds, ie, interaural time differences (ITDs), interaural level differences (ILDs), and pinna spectral cues, are all represented in the same location. These cues are first extracted separately on each side of the midline in brainstem nuclei that project to the ICs. Because of this segregation, each IC predominantly represents stimuli in the contralateral hemifield. We tested the hypothesis that commissural connections between the ICs mediate gain control that enhances sound localization acuity. We recorded IC neurons sensitive to either ITDs or ILDs in anesthetized guinea pig, before, during, and following recovery from deactivation of the contralateral IC by cryoloop cooling or microdialysis of procaine. During deactivation, responses were rescaled by divisive gain change and additive shifts, which reduced the dynamic range of ITD and ILD response functions and the ability of neurons to signal changes in sound location. These data suggest that each IC exerts multiplicative gain control and subtractive shifts over the other IC that enhances the neural representation of sound location. Furthermore, this gain control operates in a similar manner on both ITD- and ILD-sensitive neurons, suggesting a shared mechanism operates across localization cues. Our findings reveal a novel dependence of sound localization on commissural processing. SIGNIFICANCE STATEMENT: Sound localization, a fundamental process in hearing, is dependent on bilateral computations in the brainstem. How this information is transmitted from the brainstem to the auditory cortex, through several stages of processing, without loss of signal fidelity, is not clear. We show that the ability of neurons in the auditory midbrain to encode azimuthal sound location is dependent on gain control mediated by the commissure of the inferior colliculi. This finding demonstrates that commissural processing between homologous auditory nuclei, on either side of the midline, enhances the precision of sound localization.
[Mh] Termos MeSH primário: Estimulação Acústica/métodos
Vias Auditivas/fisiologia
Mesencéfalo/fisiologia
Localização de Som/fisiologia
Teto do Mesencéfalo/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Feminino
Cobaias
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.3012-15.2016


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[PMID]:26991544
[Au] Autor:Stacho M; Letzner S; Theiss C; Manns M; Güntürkün O
[Ad] Endereço:Department of Biopsychology, Faculty of Psychology, Institute of Cogntive Neuroscience, Ruhr-University Bochum, 44801, Bochum, Germany.
[Ti] Título:A GABAergic tecto-tegmento-tectal pathway in pigeons.
[So] Source:J Comp Neurol;524(14):2886-913, 2016 Oct 01.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Previous studies have demonstrated that the optic tecta of the left and right brain halves reciprocally inhibit each other in birds. In mammals, the superior colliculus receives inhibitory γ-aminobutyric acid (GABA)ergic input from the basal ganglia via both the ipsilateral and the contralateral substantia nigra pars reticulata (SNr). This contralateral SNr projection is important in intertectal inhibition. Because the basal ganglia are evolutionarily conserved, the tectal projections of the SNr may show a similar pattern in birds. Therefore, the SNr could be a relay station in an indirect tecto-tectal pathway constituting the neuronal substrate for the tecto-tectal inhibition. To test this hypothesis, we performed bilateral anterograde and retrograde tectal tracing combined with GABA immunohistochemistry in pigeons. Suprisingly, the SNr has only ipsilateral projections to the optic tectum, and these are non-GABAergic. Inhibitory GABAergic input to the contralateral optic tectum arises instead from a nearby tegmental region that receives input from the ipsilateral optic tectum. Thus, a disynaptic pathway exists that possibly constitutes the anatomical substrate for the inhibitory tecto-tectal interaction. This pathway likely plays an important role in attentional switches between the laterally placed eyes of birds. J. Comp. Neurol. 524:2886-2913, 2016. © 2016 Wiley Periodicals, Inc.
[Mh] Termos MeSH primário: Neurônios GABAérgicos/fisiologia
Colículos Superiores/fisiologia
Teto do Mesencéfalo/fisiologia
Tegmento Mesencefálico/fisiologia
Vias Visuais/fisiologia
[Mh] Termos MeSH secundário: Animais
Columbidae
Feminino
Neurônios GABAérgicos/química
Masculino
Colículos Superiores/química
Teto do Mesencéfalo/química
Tegmento Mesencefálico/química
Vias Visuais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160319
[St] Status:MEDLINE
[do] DOI:10.1002/cne.23999


  7 / 1224 MEDLINE  
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[PMID]:26978789
[Au] Autor:Ginat DT; Reid R; Frim DM
[Ad] Endereço:Department of Radiology, Pritzker School of Medicine, University of Chicago Medical Center, Chicago, Ill., USA.
[Ti] Título:Imaging Assessment of Re-Exploratory Repair of an Occipital Bone Defect-Associated Tectocerebellar Dysraphism via Hybrid Cranioplasty.
[So] Source:Pediatr Neurosurg;51(3):164-6, 2016.
[Is] ISSN:1423-0305
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Mh] Termos MeSH primário: Cerebelo/anormalidades
Cerebelo/cirurgia
Encefalocele/cirurgia
Osso Occipital/anormalidades
Osso Occipital/cirurgia
[Mh] Termos MeSH secundário: Cerebelo/diagnóstico por imagem
Criança
Encefalocele/diagnóstico por imagem
Feminino
Seres Humanos
Osso Occipital/diagnóstico por imagem
Teto do Mesencéfalo/anormalidades
Teto do Mesencéfalo/diagnóstico por imagem
Teto do Mesencéfalo/cirurgia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE
[do] DOI:10.1159/000443406


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[PMID]:26287809
[Au] Autor:Wild JM; Gaede AH
[Ad] Endereço:Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
[Ti] Título:Second tectofugal pathway in a songbird (Taeniopygia guttata) revisited: Tectal and lateral pontine projections to the posterior thalamus, thence to the intermediate nidopallium.
[So] Source:J Comp Neurol;524(5):963-85, 2016 Apr 01.
[Is] ISSN:1096-9861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Birds are almost always said to have two visual pathways from the retina to the telencephalon: thalamofugal terminating in the Wulst, and tectofugal terminating in the entopallium. Often ignored is a second tectofugal pathway that terminates in the nidopallium medial to and separate from the entopallium (e.g., Gamlin and Cohen [1986] J Comp Neurol 250:296-310). Using standard tract-tracing and electroanatomical techniques, we extend earlier evidence of a second tectofugal pathway in songbirds (Wild [1994] J Comp Neurol 349:512-535), by showing that visual projections to nucleus uvaeformis (Uva) of the posterior thalamus in zebra finches extend farther rostrally than to Uva, as generally recognized in the context of the song control system. Projections to "rUva" resulted from injections of biotinylated dextran amine into the lateral pontine nucleus (PL), and led to extensive retrograde labeling of tectal neurons, predominantly in layer 13. Injections in rUva also resulted in extensive retrograde labeling of predominantly layer 13 tectal neurons, retrograde labeling of PL neurons, and anterograde labeling of PL. It thus appears that some tectal neurons could project to rUva and PL via branched axons. Ascending projections of rUva terminated throughout a visually responsive region of the intermediate nidopallium (NI) lying between the nucleus interface medially and the entopallium laterally. Lastly, as shown by Clarke in pigeons ([1977] J Comp Neurol 174:535-552), we found that PL projects to caudal cerebellar folia.
[Mh] Termos MeSH primário: Tentilhões/fisiologia
Tegmento Pontino/fisiologia
Núcleos Posteriores do Tálamo/fisiologia
Teto do Mesencéfalo/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica/métodos
Animais
Feminino
Tentilhões/anatomia & histologia
Masculino
Estimulação Luminosa/métodos
Tegmento Pontino/citologia
Núcleos Posteriores do Tálamo/citologia
Aves Canoras
Teto do Mesencéfalo/citologia
Vias Visuais/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150820
[St] Status:MEDLINE
[do] DOI:10.1002/cne.23886


  9 / 1224 MEDLINE  
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[PMID]:26539877
[Au] Autor:Kruchinina AD; Gengin MT
[Ad] Endereço:Penza State University, Penza, Russia.
[Ti] Título:[Effect of reboxetine on activity of carboxypeptidase E in the nerve tissue of rats].
[So] Source:Biomed Khim;61(5):657-60, 2015 Sep-Oct.
[Is] ISSN:2310-6972
[Cp] País de publicação:Russia (Federation)
[La] Idioma:rus
[Ab] Resumo:Depression is one of the most common mental disorders, but its etiology is not completely understood. It is assumed that peptidergic system components are involved in the formation of this pathology. Neuropeptides play an important role in the regulation of mental and emotional states. Сarboxypeptidase E is a key enzyme of peptide processing; it regulates neuropeptide levels in the various structures of the nervous system. We have studied effects of a single dose of reboxetine on the activity of carboxypeptidase E in various brain regions and the adrenal glands of rats. The reboxetine injection decreased carboxypeptidase E activity in the pituitary gland (12 h after injection), in the pituitary gland, the quadrigeminal bodies, the medulla oblongata, the hypothalamus, the hippocampus and the amygdala (24 h after injection), in the pituitary gland and striatum (72 h after injection). The enzyme activity in adrenal glands remained basically unchanged. Apparently, the decrease of carboxypeptidase E activity may influence the level of regulatory peptides involved in the pathogenesis of depression.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Carboxipeptidase H/antagonistas & inibidores
Morfolinas/farmacologia
[Mh] Termos MeSH secundário: Glândulas Suprarrenais/efeitos dos fármacos
Glândulas Suprarrenais/enzimologia
Tonsila do Cerebelo/efeitos dos fármacos
Tonsila do Cerebelo/enzimologia
Animais
Animais não Endogâmicos
Carboxipeptidase H/metabolismo
Corpo Estriado/efeitos dos fármacos
Corpo Estriado/enzimologia
Hipocampo/efeitos dos fármacos
Hipocampo/enzimologia
Hipotálamo/efeitos dos fármacos
Hipotálamo/enzimologia
Masculino
Bulbo/efeitos dos fármacos
Bulbo/enzimologia
Hipófise/efeitos dos fármacos
Hipófise/enzimologia
Ratos
Teto do Mesencéfalo/efeitos dos fármacos
Teto do Mesencéfalo/enzimologia
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Morpholines); 947S0YZ36I (reboxetine); EC 3.4.17.10 (Carboxypeptidase H)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151106
[Lr] Data última revisão:
151106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151106
[St] Status:MEDLINE
[do] DOI:10.18097/PBMC20156105657


  10 / 1224 MEDLINE  
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[PMID]:26407010
[Au] Autor:Ung TH; Kellner C; Neira JA; Wang SH; D'Amico R; Faust PL; Canoll P; Feldstein NA; Bruce JN
[Ad] Endereço:Department of Neurological Surgery, and.
[Ti] Título:The use of fluorescein sodium in the biopsy and gross-total resection of a tectal plate glioma.
[So] Source:J Neurosurg Pediatr;16(6):732-5, 2015 Dec.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Intravenous administration of fluorescein sodium fluoresces glioma burden tissue and can be visualized using the surgical microscope with a specialized filter. Intraoperative guidance afforded through the use of fluorescein may enhance the fidelity of tissue sampling, and increase the ability to accomplish complete resection of tectal lesions. In this report the authors present the case of a 19-year-old man with a tectal anaplastic pilocytic astrocytoma in which the use of fluorescein sodium and a Zeiss Pentero surgical microscope equipped with a yellow 560 filter enabled safe complete resection. In conjunction with neurosurgical navigation, added intraoperative guidance provided by fluorescein may be beneficial in the resection of brainstem gliomas.
[Mh] Termos MeSH primário: Astrocitoma/cirurgia
Biópsia/métodos
Neoplasias Encefálicas/cirurgia
Fluoresceína/metabolismo
Neuroendoscopia
Teto do Mesencéfalo
Terceiro Ventrículo/cirurgia
Ventriculostomia/métodos
[Mh] Termos MeSH secundário: Astrocitoma/metabolismo
Astrocitoma/patologia
Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Craniotomia/métodos
Fluoresceína/administração & dosagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Microscopia/instrumentação
Microscopia/métodos
Gradação de Tumores
Teto do Mesencéfalo/metabolismo
Teto do Mesencéfalo/patologia
Teto do Mesencéfalo/cirurgia
Distribuição Tecidual
Adulto Jovem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
TPY09G7XIR (Fluorescein)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:151201
[Lr] Data última revisão:
151201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150926
[St] Status:MEDLINE
[do] DOI:10.3171/2015.5.PEDS15142



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