Base de dados : MEDLINE
Pesquisa : A08.186.211.132.772 [Categoria DeCS]
Referências encontradas : 6804 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 681 ir para página                         

  1 / 6804 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29369173
[Au] Autor:Jang SH; Chang CH; Jung YJ; Seo YS
[Ad] Endereço:Department of Physical Medicine and Rehabilitation.
[Ti] Título:Restoration of the corticoreticular pathway following shunt operation for hydrocephalus in a stroke patient.
[So] Source:Medicine (Baltimore);97(4):e9512, 2018 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a stroke patient who showed restoration of discontinued corticoreticular pathways (CRPs) on serial diffusion tensor tractography (DTT) concurrent with recovery of gait disturbance following shunt operation for hydrocephalus. PATIENT CONCERNS: A 67-year-old female patient underwent stereotactic drainage for management of intraventricular hemorrhage due to a rupture of the left posterior communicating artery. DIAGNOSES: After 4 weeks from onset, the patient exhibited quadriparesis with more severe weakness in the proximal muscles and could not even stand or walk. She underwent comprehensive rehabilitation for 3 weeks. Her quadriparesis, as a result of hydrocephalus, did not improve significantly. INTERVENTIONS: On the pre-op DTT, discontinuations (the right CRP: at subcortical white matter level, and the left CRP: at the midbrain level) of the CRP fibers from the premotor cortex were observed in both hemispheres. OUTCOMES: She underwent a ventriculo-peritoneal shunt operation and her quadriparesis improved, especially the proximal muscles. Consequently, she could walk with mild assistance on an even floor at 5 days and walk on stairs at 4 weeks after the shunt operation. On the post-op DTT, the discontinued CRP fibers were elongated to the premotor cortex in both hemispheres. LESSONS: Restoration of discontinued CRPs concurrent with recovery of gait disturbance following shunt operation for hydrocephalus was demonstrated in a stroke patient.
[Mh] Termos MeSH primário: Hidrocefalia/cirurgia
Quadriplegia/cirurgia
Formação Reticular/cirurgia
Acidente Vascular Cerebral/complicações
Derivação Ventriculoperitoneal/métodos
[Mh] Termos MeSH secundário: Idoso
Hemorragia Cerebral/etiologia
Hemorragia Cerebral/cirurgia
Drenagem/métodos
Feminino
Seres Humanos
Hidrocefalia/etiologia
Quadriplegia/etiologia
Recuperação de Função Fisiológica
Formação Reticular/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180208
[Lr] Data última revisão:
180208
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180126
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000009512


  2 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28188328
[Au] Autor:Miller DM; DeMayo WM; Bourdages GH; Wittman SR; Yates BJ; McCall AA
[Ad] Endereço:Department of Otolaryngology, Eye and Ear Institute, University of Pittsburgh, 203 Lothrop Street, Suite 500, Pittsburgh, PA, 15213, USA.
[Ti] Título:Neurons in the pontomedullary reticular formation receive converging inputs from the hindlimb and labyrinth.
[So] Source:Exp Brain Res;235(4):1195-1207, 2017 Apr.
[Is] ISSN:1432-1106
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The integration of inputs from vestibular and proprioceptive sensors within the central nervous system is critical to postural regulation. We recently demonstrated in both decerebrate and conscious cats that labyrinthine and hindlimb inputs converge onto vestibular nucleus neurons. The pontomedullary reticular formation (pmRF) also plays a key role in postural control, and additionally participates in regulating locomotion. Thus, we hypothesized that like vestibular nucleus neurons, pmRF neurons integrate inputs from the limb and labyrinth. To test this hypothesis, we recorded the responses of pmRF neurons to passive ramp-and-hold movements of the hindlimb and to whole-body tilts, in both decerebrate and conscious felines. We found that pmRF neuronal activity was modulated by hindlimb movement in the rostral-caudal plane. Most neurons in both decerebrate (83% of units) and conscious (61% of units) animals encoded both flexion and extension movements of the hindlimb. In addition, hindlimb somatosensory inputs converged with vestibular inputs onto pmRF neurons in both preparations. Pontomedullary reticular formation neurons receiving convergent vestibular and limb inputs likely participate in balance control by governing reticulospinal outflow.
[Mh] Termos MeSH primário: Neurônios Motores/fisiologia
Formação Reticular/citologia
Vestíbulo do Labirinto/fisiologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Mapeamento Encefálico
Gatos
Estado de Consciência
Estado de Descerebração
Estimulação Elétrica
Feminino
Membro Posterior/fisiologia
Masculino
Movimento/fisiologia
Rotação
Vestíbulo do Labirinto/inervação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170830
[Lr] Data última revisão:
170830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170212
[St] Status:MEDLINE
[do] DOI:10.1007/s00221-017-4875-x


  3 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28072702
[Au] Autor:Jang SH; Chang CH; Jung YJ; Kwon HG
[Ad] Endereço:aDepartment of Physical Medicine and Rehabilitation bDepartment of Neurosurgery, College of Medicine, Yeungnam University, Daegu, Republic of Korea.
[Ti] Título:Hypersomnia due to injury of the ventral ascending reticular activating system following cerebellar herniation: A case report.
[So] Source:Medicine (Baltimore);96(1):e5678, 2017 Jan.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a patient with hypersomnia who showed injury of the lower ascending reticular activating system (ARAS) following cerebellar herniation due to a cerebellar infarct, detected on diffusion tensor tractography (DTT). PATIENT CONCERNS: A 53-year-old male patient was diagnosed as a left cerebellar infarct, and underwent decompressive suboccipital craniectomy due to brain edema at 2 days after the onset of a cerebellar infarct. Three weeks after onset when the patient started rehabilitation, he showed hypersomnia without impairment of consciousness; he fell asleep most of daytime without external stimulation and showed an abnormal score on the Epworth Sleepiness Scale: 15 (full score: 24, cut off for hypersomnia: 10). DIAGNOSES AND OUTCOMES: On 3-week DTT, narrowing of the upper portion of the lower ventral ARAS between the pontine reticular formation and the hypothalamus was observed on both sides. In addition, partial tearing was observed in the middle portion of the right lower ventral ARAS. LESSONS: In conclusion, we found injury of the lower ventral ARAS in a patient with hypersomnia following cerebellar herniation due to a cerebellar infarct.
[Mh] Termos MeSH primário: Distúrbios do Sono por Sonolência Excessiva/etiologia
Encefalocele/complicações
Formação Reticular/diagnóstico por imagem
[Mh] Termos MeSH secundário: Imagem de Tensor de Difusão
Seres Humanos
Masculino
Meia-Idade
Formação Reticular/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170111
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000005678


  4 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27891607
[Au] Autor:Tazoe T; Perez MA
[Ad] Endereço:University of Miami, Department of Neurological Surgery, The Miami Project to Cure Paralysis, Miami, FL, 33136, USA.
[Ti] Título:Cortical and reticular contributions to human precision and power grip.
[So] Source:J Physiol;595(8):2715-2730, 2017 Apr 15.
[Is] ISSN:1469-7793
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:KEY POINTS: The corticospinal tract contributes to the control of finger muscles during precision and power grip. We explored the neural mechanisms contributing to changes in corticospinal excitability during these gripping configurations. Motor evoked potentials (MEPs) elicited by cortical, but not by subcortical, stimulation were more suppressed during power grip compared with precision grip and index finger abduction. Intracortical inhibition was more reduced during power grip compared with the other tasks. An acoustic startle cue, a stimulus that engages the reticular system, suppressed MEP size during power grip to a lesser extent than during the other tasks at a cortical level and this positively correlated with changes in intracortical inhibition. Our findings suggest that changes in corticospinal excitability during gross more than fine finger manipulations are largely cortical in origin and that the reticular system contributed, at least in part, to these effects. ABSTRACT: It is well accepted that the corticospinal tract contributes to the control of finger muscles during precision and power grip in humans but the neural mechanisms involved remain poorly understood. Here, we examined motor evoked potentials elicited by cortical and subcortical stimulation of corticospinal axons (MEPs and CMEPs, respectively) and the activity in intracortical circuits (suppression of voluntary electromyography) and spinal motoneurons (F-waves) in an intrinsic hand muscle during index finger abduction, precision grip and power grip. We found that the size of MEPs, but not CMEPs, was more suppressed during power grip compared with precision grip and index finger abduction, suggesting a cortical origin for these effects. Notably, intracortical inhibition was more reduced during power grip compared with the other tasks. To further examine the origin of changes in intracortical inhibition we assessed the contribution of the reticular system, which projects to cortical neurons, and projects to spinal motoneurons controlling hand muscles. An acoustic startle cue, which engages the reticular system, suppressed MEP size during power grip to a lesser extent than during the other tasks and this positively correlated with changes in intracortical inhibition. A startle cue decreased intracortical inhibition, but not CMEPs, during power grip. F-waves remained unchanged across conditions. Our novel findings show that changes in corticospinal excitability present during power grip compared with fine finger manipulations are largely cortical in origin and suggest that the reticular system contributed, at least in part, to these effects.
[Mh] Termos MeSH primário: Potencial Evocado Motor/fisiologia
Força da Mão/fisiologia
Córtex Motor/fisiologia
Tratos Piramidais/fisiologia
Formação Reticular/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica/métodos
Adulto
Feminino
Seres Humanos
Masculino
Distribuição Aleatória
Reflexo de Sobressalto/fisiologia
Estimulação Magnética Transcraniana/métodos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161129
[St] Status:MEDLINE
[do] DOI:10.1113/JP273679


  5 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:27798137
[Au] Autor:Foysal KM; de Carvalho F; Baker SN
[Ad] Endereço:Institute of Neurosciences, Newcastle University, Newcastle upon Tyne NE2 4HH, United Kingdom.
[Ti] Título:Spike Timing-Dependent Plasticity in the Long-Latency Stretch Reflex Following Paired Stimulation from a Wearable Electronic Device.
[So] Source:J Neurosci;36(42):10823-10830, 2016 Oct 19.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The long-latency stretch reflex (LLSR) in human elbow muscles probably depends on multiple pathways; one possible contributor is the reticulospinal tract. Here we attempted to induce plastic changes in the LLSR by pairing noninvasive stimuli that are known to activate reticulospinal pathways, at timings predicted to cause spike timing-dependent plasticity in the brainstem. In healthy human subjects, reflex responses in flexor muscles were recorded following extension perturbations at the elbow. Subjects were then fitted with a portable device that delivered auditory click stimuli through an earpiece, and electrical stimuli around motor threshold to the biceps muscle via surface electrodes. We tested the following four paradigms: biceps stimulus 10 ms before click (Bi-10ms-C); click 25 ms before biceps (C-25ms-Bi); click alone (C only); and biceps alone (Bi only). The average stimulus rate was 0.67 Hz. Subjects left the laboratory wearing the device and performed normal daily activities. Approximately 7 h later, they returned, and stretch reflexes were remeasured. The LLSR was significantly enhanced in the biceps muscle (on average by 49%) after the Bi-10ms-C paradigm, but was suppressed for C-25ms-Bi (by 31%); it was unchanged for Bi only and C only. No paradigm induced LLSR changes in the unstimulated brachioradialis muscle. Although we cannot exclude contributions from spinal or cortical pathways, our results are consistent with spike timing-dependent plasticity in reticulospinal circuits, specific to the stimulated muscle. This is the first demonstration that the LLSR can be modified via paired-pulse methods, and may open up new possibilities in motor systems neuroscience and rehabilitation. SIGNIFICANCE STATEMENT: This report is the first demonstration that the long-latency stretch reflex can be modified by repeated, precisely timed pairing of stimuli known to activate brainstem pathways. Furthermore, pairing was achieved with a portable electronic device capable of delivering many more stimulus repetitions than conventional laboratory studies. Our findings open up new possibilities for basic research into these underinvestigated pathways, which are important for motor control in healthy individuals. They may also lead to paradigms capable of enhancing rehabilitation in patients recovering from damage, such as after stroke or spinal cord injury.
[Mh] Termos MeSH primário: Plasticidade Neuronal/fisiologia
Reflexo de Estiramento/fisiologia
[Mh] Termos MeSH secundário: Estimulação Acústica
Adulto
Idoso
Idoso de 80 Anos ou mais
Braço/inervação
Braço/fisiologia
Tronco Encefálico/fisiologia
Cotovelo/inervação
Cotovelo/fisiologia
Estimulação Elétrica
Feminino
Voluntários Saudáveis
Seres Humanos
Masculino
Meia-Idade
Músculo Esquelético/inervação
Músculo Esquelético/fisiologia
Formação Reticular/fisiologia
Medula Espinal/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161101
[St] Status:MEDLINE


  6 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27663632
[Au] Autor:Puri BK
[Ad] Endereço:Department of Medicine, Imperial College London, London, UK. Electronic address: basant.puri@imperial.ac.uk.
[Ti] Título:The effects of stress on the dorsal raphe nucleus of the reticular formation and its role in the aetiology of disparate medical and neuropsychiatric disorders.
[So] Source:Med Hypotheses;96:A4-A5, 2016 Nov.
[Is] ISSN:1532-2777
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Núcleo Dorsal da Rafe/fisiopatologia
Estresse Psicológico
[Mh] Termos MeSH secundário: Animais
Epilepsia do Lobo Temporal/complicações
Epilepsia do Lobo Temporal/fisiopatologia
Seres Humanos
Hipertensão/complicações
Hipertensão/fisiopatologia
Transtornos de Enxaqueca/complicações
Transtornos de Enxaqueca/fisiopatologia
Neurônios
Respiração
Formação Reticular
Esquizofrenia/complicações
Esquizofrenia/fisiopatologia
Transtornos de Estresse Pós-Traumáticos/complicações
Transtornos de Estresse Pós-Traumáticos/fisiopatologia
Acidente Vascular Cerebral/complicações
Acidente Vascular Cerebral/fisiopatologia
[Pt] Tipo de publicação:EDITORIAL
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


  7 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27383596
[Au] Autor:Song H; Hayes JA; Vann NC; Wang X; LaMar MD; Del Negro CA
[Ad] Endereço:Departments of Applied Science and.
[Ti] Título:Functional Interactions between Mammalian Respiratory Rhythmogenic and Premotor Circuitry.
[So] Source:J Neurosci;36(27):7223-33, 2016 Jul 06.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: Breathing in mammals depends on rhythms that originate from the preBötzinger complex (preBötC) of the ventral medulla and a network of brainstem and spinal premotor neurons. The rhythm-generating core of the preBötC, as well as some premotor circuits, consist of interneurons derived from Dbx1-expressing precursors (Dbx1 neurons), but the structure and function of these networks remain incompletely understood. We previously developed a cell-specific detection and laser ablation system to interrogate respiratory network structure and function in a slice model of breathing that retains the preBötC, the respiratory-related hypoglossal (XII) motor nucleus and XII premotor circuits. In spontaneously rhythmic slices, cumulative ablation of Dbx1 preBötC neurons decreased XII motor output by ∼50% after ∼15 cell deletions, and then decelerated and terminated rhythmic function altogether as the tally increased to ∼85 neurons. In contrast, cumulatively deleting Dbx1 XII premotor neurons decreased motor output monotonically but did not affect frequency nor stop XII output regardless of the ablation tally. Here, we couple an existing preBötC model with a premotor population in several topological configurations to investigate which one may replicate the laser ablation experiments best. If the XII premotor population is a "small-world" network (rich in local connections with sparse long-range connections among constituent premotor neurons) and connected with the preBötC such that the total number of incoming synapses remains fixed, then the in silico system successfully replicates the in vitro laser ablation experiments. This study proposes a feasible configuration for circuits consisting of Dbx1-derived interneurons that generate inspiratory rhythm and motor pattern. SIGNIFICANCE STATEMENT: To produce a breathing-related motor pattern, a brainstem core oscillator circuit projects to a population of premotor interneurons, but the assemblage of this network remains incompletely understood. Here we applied network modeling and numerical simulation to discover respiratory circuit configurations that successfully replicate photonic cell ablation experiments targeting either the core oscillator or premotor network, respectively. If premotor neurons are interconnected in a so-called "small-world" network with a fixed number of incoming synapses balanced between premotor and rhythmogenic neurons, then our simulations match their experimental benchmarks. These results provide a framework of experimentally testable predictions regarding the rudimentary structure and function of respiratory rhythm- and pattern-generating circuits in the brainstem of mammals.
[Mh] Termos MeSH primário: Neurônios Motores/fisiologia
Rede Nervosa/fisiologia
Periodicidade
Respiração
Centro Respiratório/citologia
Medula Espinal/citologia
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Proteínas de Homeodomínio/metabolismo
Interneurônios/fisiologia
Modelos Neurológicos
Técnicas de Patch-Clamp
Centro Respiratório/fisiologia
Formação Reticular/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dbx1 protein, mouse); 0 (Homeodomain Proteins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170718
[Lr] Data última revisão:
170718
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0296-16.2016


  8 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:27368033
[Au] Autor:Jang SH; Hyun YJ; Lee HD
[Ad] Endereço:aDepartment of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea, bThe Department of Diagnostic Radiology, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
[Ti] Título:Recovery of consciousness and an injured ascending reticular activating system in a patient who survived cardiac arrest: A case report.
[So] Source:Medicine (Baltimore);95(26):e4041, 2016 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We report on a patient who survived cardiac arrest and showed recovery of consciousness and an injured ARAS at the early stage of hypoxic-ischemic brain injury (HI- BI) for 3 weeks, which was demonstrated by diffusion tensor tractography (DTT).A 52-year-old male patient who had suffered cardiac arrest caused by acute coronary syndrome was resuscitated immediately by a layman and paramedics for ∼25 minutes. He was then transferred immediately to the emergency room of a local medical center. When starting rehabilitation at 2 weeks after onset, his consciousness was impaired, with a Glasgow Coma Scale (GCS) score of 8 and Coma Recovery Scale-Revised (GRS-R) score of 8. He underwent comprehensive rehabilitative therapy, including drugs for recovery of consciousness. He recovered well and rapidly so that his consciousness had recovered to full scores in terms of GCS:15 and GRS-R:23 at 5 weeks after onset.The left lower dorsal and right lower ventral ARAS had become thicker on 5-week DTT compared with 2-week DTT (Fig. 1B). Regarding the change of neural connectivity of the thalamic ILN, increased neural connectivity to the basal forebrain and prefrontal cortex was observed in both hemispheres on 5-week DTT compared with 2-week DTT.Recovery of an injured ARAS was demonstrated in a patient who survived cardiac arrest and his consciousness showed rapid and good recovery for 3 weeks at the early stage of HI-BI.
[Mh] Termos MeSH primário: Estado de Consciência
Parada Cardíaca/psicologia
Formação Reticular
[Mh] Termos MeSH secundário: Imagem de Tensor de Difusão
Escala de Coma de Glasgow
Parada Cardíaca/complicações
Seres Humanos
Hipóxia-Isquemia Encefálica/etiologia
Hipóxia-Isquemia Encefálica/patologia
Masculino
Meia-Idade
Recuperação de Função Fisiológica
Formação Reticular/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160702
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000004041


  9 / 6804 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27147647
[Au] Autor:Goetz L; Piallat B; Bhattacharjee M; Mathieu H; David O; Chabardès S
[Ad] Endereço:Université Grenoble Alpes, F-38000 Grenoble, France, Inserm, U1216, Grenoble Institut des Neurosciences, F-38000 Grenoble, France.
[Ti] Título:On the Role of the Pedunculopontine Nucleus and Mesencephalic Reticular Formation in Locomotion in Nonhuman Primates.
[So] Source:J Neurosci;36(18):4917-29, 2016 May 04.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: The mesencephalic reticular formation (MRF) is formed by the pedunculopontine and cuneiform nuclei, two neuronal structures thought to be key elements in the supraspinal control of locomotion, muscle tone, waking, and REM sleep. The role of MRF has also been advocated in modulation of state of arousal leading to transition from wakefulness to sleep and it is further considered to be a main player in the pathophysiology of gait disorders seen in Parkinson's disease. However, the existence of a mesencephalic locomotor region and of an arousal center has not yet been demonstrated in primates. Here, we provide the first extensive electrophysiological mapping of the MRF using extracellular recordings at rest and during locomotion in a nonhuman primate (NHP) (Macaca fascicularis) model of bipedal locomotion. We found different neuronal populations that discharged according to a phasic or a tonic mode in response to locomotion, supporting the existence of a locomotor neuronal circuit within these MRF in behaving primates. Altogether, these data constitute the first electrophysiological characterization of a locomotor neuronal system present within the MRF in behaving NHPs under normal conditions, in accordance with several studies done in different experimental animal models. SIGNIFICANCE STATEMENT: We provide the first extensive electrophysiological mapping of the two major components of the mesencephalic reticular formation (MRF), namely the pedunculopontine and cuneiform nuclei. We exploited a nonhuman primate (NHP) model of bipedal locomotion with extracellular recordings in behaving NHPs at rest and during locomotion. Different MRF neuronal groups were found to respond to locomotion, with phasic or tonic patterns of response. These data constitute the first electrophysiological evidences of a locomotor neuronal system within the MRF in behaving NHPs.
[Mh] Termos MeSH primário: Locomoção/fisiologia
Mesencéfalo/fisiologia
Núcleo Tegmental Pedunculopontino/fisiologia
Primatas/fisiologia
Formação Reticular/fisiologia
[Mh] Termos MeSH secundário: Animais
Eletrodos Implantados
Fenômenos Eletrofisiológicos
Feminino
Macaca fascicularis
Imagem por Ressonância Magnética
Masculino
Mesencéfalo/citologia
Microeletrodos
Neurônios/fisiologia
Núcleo Tegmental Pedunculopontino/citologia
Formação Reticular/citologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170814
[Lr] Data última revisão:
170814
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160506
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.2514-15.2016


  10 / 6804 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27041498
[Au] Autor:Deschênes M; Takatoh J; Kurnikova A; Moore JD; Demers M; Elbaz M; Furuta T; Wang F; Kleinfeld D
[Ad] Endereço:Department of Psychiatry and Neuroscience, Laval University, Québec City, QC G1J 2R3, Canada. Electronic address: martin.deschenes@crulrg.ulaval.ca.
[Ti] Título:Inhibition, Not Excitation, Drives Rhythmic Whisking.
[So] Source:Neuron;90(2):374-87, 2016 Apr 20.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Bötzinger complex (preBötC) and the vibrissa-related region of the intermediate reticular formation (vIRt). We examine how these oscillators synergize to control sniffing and whisking. We find that the vIRt contains glycinergic/GABAergic cells that rhythmically inhibit vibrissa facial motoneurons. As a basis for the entrainment of whisking by breathing, but not vice versa, we provide evidence for unidirectional connections from the preBötC to the vIRt. The preBötC further contributes to the control of the mystacial pad. Lastly, we show that bilateral synchrony of whisking relies on the respiratory rhythm, consistent with commissural connections between preBötC cells. These data yield a putative circuit in which the preBötC acts as a master clock for the synchronization of vibrissa, pad, and snout movements, as well as for the bilateral synchronization of whisking.
[Mh] Termos MeSH primário: Relógios Biológicos/fisiologia
Inibição Neural/fisiologia
Periodicidade
Vibrissas/fisiologia
[Mh] Termos MeSH secundário: Animais
Neurônios GABAérgicos/fisiologia
Glicina/fisiologia
Neurônios Motores/fisiologia
Vias Neurais/fisiologia
Neurônios/fisiologia
Ratos
Respiração
Formação Reticular/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
TE7660XO1C (Glycine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE



página 1 de 681 ir para página                         
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde