Base de dados : MEDLINE
Pesquisa : A08.186.211.132.810.428 [Categoria DeCS]
Referências encontradas : 45 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 5 ir para página              

  1 / 45 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:23307742
[Au] Autor:Di Meglio T; Kratochwil CF; Vilain N; Loche A; Vitobello A; Yonehara K; Hrycaj SM; Roska B; Peters AH; Eichmann A; Wellik D; Ducret S; Rijli FM
[Ad] Endereço:Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland.
[Ti] Título:Ezh2 orchestrates topographic migration and connectivity of mouse precerebellar neurons.
[So] Source:Science;339(6116):204-7, 2013 Jan 11.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:We investigated the role of histone methyltransferase Ezh2 in tangential migration of mouse precerebellar pontine nuclei, the main relay between neocortex and cerebellum. By counteracting the sonic hedgehog pathway, Ezh2 represses Netrin1 in dorsal hindbrain, which allows normal pontine neuron migration. In Ezh2 mutants, ectopic Netrin1 derepression results in abnormal migration and supernumerary nuclei integrating in brain circuitry. Moreover, intrinsic topographic organization of pontine nuclei according to rostrocaudal progenitor origin is maintained throughout migration and correlates with patterned cortical input. Ezh2 maintains spatially restricted Hox expression, which, in turn, regulates differential expression of the repulsive receptor Unc5b in migrating neurons; together, they generate subsets with distinct responsiveness to environmental Netrin1. Thus, Ezh2-dependent epigenetic regulation of intrinsic and extrinsic transcriptional programs controls topographic neuronal guidance and connectivity in the cortico-ponto-cerebellar pathway.
[Mh] Termos MeSH primário: Cerebelo/embriologia
Vias Neurais/embriologia
Neurônios/fisiologia
Complexo Repressor Polycomb 2/metabolismo
Ponte/embriologia
[Mh] Termos MeSH secundário: Animais
Movimento Celular
Cerebelo/citologia
Cerebelo/metabolismo
Córtex Cerebral/embriologia
Córtex Cerebral/fisiologia
Proteína Potenciadora do Homólogo 2 de Zeste
Epigênese Genética
Regulação da Expressão Gênica no Desenvolvimento
Genes Homeobox
Proteínas de Homeodomínio/metabolismo
Metencéfalo/embriologia
Camundongos
Camundongos Transgênicos
Fatores de Crescimento Neural/genética
Fatores de Crescimento Neural/metabolismo
Receptores de Netrina
Netrina-1
Vias Neurais/fisiologia
Complexo Repressor Polycomb 2/genética
Ponte/citologia
Ponte/metabolismo
Receptores de Superfície Celular/genética
Receptores de Superfície Celular/metabolismo
Transcrição Genética
Proteínas Supressoras de Tumor/genética
Proteínas Supressoras de Tumor/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Homeodomain Proteins); 0 (Nerve Growth Factors); 0 (Netrin Receptors); 0 (Receptors, Cell Surface); 0 (Tumor Suppressor Proteins); 158651-98-0 (Netrin-1); EC 2.1.1.43 (Enhancer of Zeste Homolog 2 Protein); EC 2.1.1.43 (Ezh2 protein, mouse); EC 2.1.1.43 (Polycomb Repressive Complex 2)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130112
[St] Status:MEDLINE
[do] DOI:10.1126/science.1229326


  2 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22404534
[Au] Autor:Suzuki A; Harada H; Nakamura H
[Ad] Endereço:Department of Molecular Neurobiology, Graduate School of Life Sciences and Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, 980-8575 Sendai, Japan.
[Ti] Título:Nuclear translocation of FGF8 and its implication to induce Sprouty2.
[So] Source:Dev Growth Differ;54(4):463-73, 2012 May.
[Is] ISSN:1440-169X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Fibroblast growth factor 8 (FGF8) functions as a local organizing signal for the tectum and cerebellum. FGF8 activates Ras-ERK signaling pathway to induce cerebellar development. We paid attention to the difference in the expression pattern of the molecules that are induced by FGF8 in the mid-hind brain region during normal development and after FGF8 misexpression; some are expressed in the area corresponding to the ERK activation domain but the others are expressed corresponding to the Fgf8 expression domain. Since some of the FGF family members are localized in the nucleus, we wondered if FGF8 could localize in the nuclei and function in the nucleus. We first show that in cultured NIH3T3 cells transfected FGF8b could localize in the nucleus. Transfected FGF8b could also localize in the nucleus of the cells in the chick neural tube. In mouse embryonic neural tube, we detected endogenous FGF8 in the nuclei. Implantation of an FGF8b-soaked bead showed that exogenous FGF8b could be translocated to the nuclei in the isthmus. Furthermore, signal-peptide-deletion mutant of FGF8b mainly localized in the nuclei, and induced Sprouty2 without activating ERK in the mesencephalon. Signal-peptide-deletion mutant of FGF8b could not induce Pax2 expression. Taken together, we concluded that FGF8b could be translocated to the nuclei, and that the nuclear FGF8 could function as transcriptional regulator to induce Sprouty2 in the isthmus.
[Mh] Termos MeSH primário: Núcleo Celular/metabolismo
Fator 8 de Crescimento de Fibroblasto/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Proteínas de Membrana/metabolismo
[Mh] Termos MeSH secundário: Transporte Ativo do Núcleo Celular
Proteínas Adaptadoras de Transdução de Sinal
Animais
Núcleo Celular/genética
Embrião de Galinha
Eletroporação
Embrião de Mamíferos/citologia
Embrião de Mamíferos/embriologia
Desenvolvimento Embrionário
Feminino
Fator 8 de Crescimento de Fibroblasto/genética
Imuno-Histoquímica
Peptídeos e Proteínas de Sinalização Intracelular
Sistema de Sinalização das MAP Quinases
Proteínas de Membrana/genética
Mesencéfalo/citologia
Mesencéfalo/embriologia
Metencéfalo/citologia
Metencéfalo/embriologia
Camundongos
Camundongos Endogâmicos ICR
Microscopia Confocal
Células NIH 3T3
Tubo Neural/citologia
Tubo Neural/embriologia
Fator de Transcrição PAX2/genética
Fator de Transcrição PAX2/metabolismo
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
Sinais Direcionadores de Proteínas
Estrutura Terciária de Proteína
Proteínas Recombinantes/genética
Proteínas Recombinantes/metabolismo
Deleção de Sequência
Transfecção
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Adaptor Proteins, Signal Transducing); 0 (Fgf8 protein, mouse); 0 (Intracellular Signaling Peptides and Proteins); 0 (Membrane Proteins); 0 (PAX2 Transcription Factor); 0 (Pax2 protein, mouse); 0 (Protein Isoforms); 0 (Protein Sorting Signals); 0 (Recombinant Proteins); 0 (Spry2 protein, mouse); 148997-75-5 (Fibroblast Growth Factor 8)
[Em] Mês de entrada:1209
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120313
[St] Status:MEDLINE
[do] DOI:10.1111/j.1440-169X.2012.01332.x


  3 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:22264868
[Au] Autor:Yang CP; Wang HA; Tsai TH; Fan A; Hsu CL; Chen CJ; Hong CJ; Chen YM
[Ad] Endereço:Institute of Public Health, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
[Ti] Título:Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments.
[So] Source:Eur Neuropsychopharmacol;22(8):596-606, 2012 Aug.
[Is] ISSN:1873-7862
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Glycine N-methyltransferase (GNMT) affects cellular methylation capacity through regulating the ratio between S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH). The product of its enzymatic reaction-sarcosine has antipsychotic effect in patients with schizophrenia. In this study, through RT-PCR and immunohistochemical staining, we demonstrated that GNMT expressed in various neurons located in the cerebral cortex, hippocampus, substantia nigra and cerebellum. Compared to the wild-type mice, Gnmt-/- mice had significantly lower level of sarcosine in the cerebral cortex. Real-time PCR identified genes involved in the methionine metabolism (Dnmt1 and Dnmt3a), ErbB (Nrg1 and ErbB4) and mTOR (Akt2, S6, S6k1 and S6k2) signaling pathways were dysregulated significantly in the cortex of Gnmt-/- mice. Acoustic startle reflex test demonstrated that Gnmt-/- mice had significantly lower level of prepulse inhibition and the deficit was ameliorated through clozapine or sarcosine treatment. Furthermore, liver-specific-human-GNMT transgenic with Gnmt-/- (Tg-GNMT/Gnmt-/-) mice were used to rule out that the phenotype was due to abnormal liver function. In summary, the neuropsychological abnormalities found in Gnmt-/- mice may represent an endophenotype of schizophrenia. GNMT plays an important role in maintaining normal physiological function of brain and Tg-GNMT/Gnmt-/- mice are useful models for development of therapeutics for patients with schizophrenia.
[Mh] Termos MeSH primário: Antipsicóticos/uso terapêutico
Modelos Animais de Doenças
Glicina N-Metiltransferase/metabolismo
Metencéfalo/efeitos dos fármacos
Neurônios/efeitos dos fármacos
Esquizofrenia/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Clozapina/uso terapêutico
Cruzamentos Genéticos
Regulação da Expressão Gênica/efeitos dos fármacos
Glicina N-Metiltransferase/genética
Seres Humanos
Masculino
Metencéfalo/metabolismo
Metencéfalo/patologia
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Knockout
Camundongos Transgênicos
Proteínas do Tecido Nervoso/genética
Proteínas do Tecido Nervoso/metabolismo
Neurônios/metabolismo
Neurônios/patologia
Especificidade de Órgãos
RNA Mensageiro/metabolismo
Sarcosina/metabolismo
Sarcosina/uso terapêutico
Esquizofrenia/metabolismo
Esquizofrenia/patologia
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Nerve Tissue Proteins); 0 (RNA, Messenger); EC 2.1.1.20 (GNMT protein, human); EC 2.1.1.20 (Glycine N-Methyltransferase); EC 2.1.1.20 (Gnmt protein, mouse); J60AR2IKIC (Clozapine); Z711V88R5F (Sarcosine)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120124
[St] Status:MEDLINE
[do] DOI:10.1016/j.euroneuro.2011.12.007


  4 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:21733311
[Au] Autor:Benítez-Santana T; Juárez-Carrillo E; Betancor MB; Torrecillas S; Caballero MJ; Izquierdo MS
[Ad] Endereço:Grupo de Investigación en Acuicultura, Universidad de Las Palmas de Gran Canaria, Instituto Canario de Ciencias Marinas, PO 56, 35200 Telde, Las Palmas, Canary Islands, Spain. tibi.benitez.santana@gmail.com
[Ti] Título:Increased Mauthner cell activity and escaping behaviour in seabream fed long-chain PUFA.
[So] Source:Br J Nutr;107(2):295-301, 2012 Jan.
[Is] ISSN:1475-2662
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:There is limited information on the specific effects of long-chain PUFA (LCPUFA) on neuron development and functioning. Deficiency of those essential fatty acids impairs escape and avoidance behaviour in fish, where Mauthner cells (M-cells) play a particularly important role in initiating this response. Gilthead seabream larvae fed two different LCPUFA profiles were challenged with a sonorous stimulus. Feeding n-3 LCPUFA increased the content of these fatty acids in fish tissues and caused a higher number of larvae to react to the stimulus with a faster burst swimming speed response. This faster startle response in fish fed n-3 LCPUFA was also associated with an increased immune-positive neural response, particularly in M-cells, denoting a higher production of acetylcholine. The present study shows the first evidence of the effect of n-3 LCPUFA on the functioning of particular neurons in fish, the M-cells and the behaviour response that they modulate to escape from a sound stimulus.
[Mh] Termos MeSH primário: Reação de Fuga
Ácidos Graxos Ômega-3/administração & dosagem
Metencéfalo/fisiologia
Neurônios/fisiologia
Dourada/fisiologia
[Mh] Termos MeSH secundário: Acetilcolina/metabolismo
Animais
Colina O-Acetiltransferase/metabolismo
Neurônios Colinérgicos/citologia
Neurônios Colinérgicos/fisiologia
Deficiências Nutricionais/patologia
Deficiências Nutricionais/fisiopatologia
Deficiências Nutricionais/prevenção & controle
Deficiências Nutricionais/veterinária
Ácidos Graxos Essenciais/administração & dosagem
Ácidos Graxos Essenciais/deficiência
Ácidos Graxos Essenciais/uso terapêutico
Ácidos Graxos Ômega-3/metabolismo
Ácidos Graxos Ômega-3/uso terapêutico
Doenças dos Peixes/patologia
Doenças dos Peixes/fisiopatologia
Doenças dos Peixes/prevenção & controle
Óleos de Peixe/administração & dosagem
Óleos de Peixe/uso terapêutico
Proteínas de Peixes/metabolismo
Metencéfalo/citologia
Metencéfalo/crescimento & desenvolvimento
Metencéfalo/fisiopatologia
Músculo Esquelético/crescimento & desenvolvimento
Músculo Esquelético/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Neurogênese
Neurônios/citologia
Neurônios/patologia
Distribuição Aleatória
Reflexo de Sobressalto
Dourada/crescimento & desenvolvimento
Óleo de Soja/administração & dosagem
Óleo de Soja/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids, Essential); 0 (Fatty Acids, Omega-3); 0 (Fish Oils); 0 (Fish Proteins); 0 (Nerve Tissue Proteins); 8001-22-7 (Soybean Oil); EC 2.3.1.6 (Choline O-Acetyltransferase); N9YNS0M02X (Acetylcholine)
[Em] Mês de entrada:1203
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110708
[St] Status:MEDLINE
[do] DOI:10.1017/S0007114511002807


  5 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:20816794
[Au] Autor:Sakurai Y; Kurokawa D; Kiyonari H; Kajikawa E; Suda Y; Aizawa S
[Ad] Endereço:Laboratory for Vertebrate Body Plan, Center for Developmental Biology, RIKEN Kobe, 2-2-3 Minatojima Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
[Ti] Título:Otx2 and Otx1 protect diencephalon and mesencephalon from caudalization into metencephalon during early brain regionalization.
[So] Source:Dev Biol;347(2):392-403, 2010 Nov 15.
[Is] ISSN:1095-564X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Otx2 is expressed in each step and site of head development. To dissect each Otx2 function we have identified a series of Otx2 enhancers. The Otx2 expression in the anterior neuroectoderm is regulated by the AN enhancer and the subsequent expression in forebrain and midbrain later than E8.5 by FM1 and FM2 enhancers; the Otx1 expression takes place at E8.0. In telencephalon later than E9.5 Otx1 continues to be expressed in the entire pallium, while the Otx2 expression is confined to the most medial pallium. To determine the Otx functions in forebrain and midbrain development we have generated mouse mutants that lack both FM1 and FM2 enhancers (DKO: Otx2(ΔFM1ΔFM2/ΔFM1ΔFM2)) and examined the TKO (Otx1(-/-)Otx2(ΔFM1ΔFM2/ΔFM1ΔFM2)) phenotype. The mutants develop normally until E8.0, but subsequently by E9.5 the diencephalon, including thalamic eminence and prethalamus, and the mesencephalon are caudalized into metencephalon consisting of isthmus and rhombomere 1; the caudalization does not extend to rhombomere 2 and more caudal rhombomeres. In rostral forebrain, neopallium, ganglionic eminences and hypothalamus in front of prethalamus develop; we propose that they become insensitive to the caudalization with the switch from the Otx2 expression under the AN enhancer to that under FM1 and FM2 enhancers. In contrast, the medial pallium requires Otx1 and Otx2 for its development later than E9.5, and the Otx2 expression in diencepalon and mesencephalon later than E9.5 is also directed by an enhancer other than FM1 and FM2 enhancers.
[Mh] Termos MeSH primário: Encéfalo/embriologia
Encéfalo/metabolismo
Fatores de Transcrição Otx/metabolismo
[Mh] Termos MeSH secundário: Animais
Sequência de Bases
Padronização Corporal
Primers do DNA/genética
Diencéfalo/embriologia
Diencéfalo/metabolismo
Elementos Facilitadores Genéticos
Feminino
Regulação da Expressão Gênica no Desenvolvimento
Mesencéfalo/embriologia
Mesencéfalo/metabolismo
Metencéfalo/embriologia
Metencéfalo/metabolismo
Camundongos
Camundongos Knockout
Camundongos Mutantes
Camundongos Transgênicos
Fatores de Transcrição Otx/deficiência
Fatores de Transcrição Otx/genética
Gravidez
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA Primers); 0 (Otx Transcription Factors); 0 (Otx1 protein, mouse); 0 (Otx2 protein, mouse)
[Em] Mês de entrada:1011
[Cu] Atualização por classe:101019
[Lr] Data última revisão:
101019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100907
[St] Status:MEDLINE
[do] DOI:10.1016/j.ydbio.2010.08.028


  6 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:19123244
[Au] Autor:Schmidt MJ; Pilatus U; Wigger A; Kramer M; Oelschläger HA
[Ad] Endereço:Small Animal Clinic, Justus Liebig-University, Giessen, Germany. martin.j.schmidt@vetmed.uni-giessen.de
[Ti] Título:Neuroanatomy of the calf brain as revealed by high-resolution magnetic resonance imaging.
[So] Source:J Morphol;270(6):745-58, 2009 Jun.
[Is] ISSN:1097-4687
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Here, we want to assess the benefit of high-resolution and high-contrast magnetic resonance imaging (MRI) for detailed documentation of internal brain morphology in formalin-fixed whole head specimens of the full-term calf brain (Bos taurus). Imaging was performed on a Siemens 1.5 T scanner. Optimum contrast was achieved using a 3D sequence with a flip angle of 30 degrees , repetition time (TR) of 20 ms, echo time (TE) of 6.8 ms, and an interpolated matrix of 1024 x 1024. In plane resolution was 0.25 mm. Computer-generated three-dimensional images were reconstructed from the original scans in the coronal plane. This study shows that MRI is capable to identify delicate structures in immature brain specimens. The use of MRI in comparative morphology facilitates the examination of series of brains or brain samples in a reasonable time. The comprehensive description of species- and group-specific brain features in MRI scans of Bos taurus will complement existing data for diagnostic imaging and neuromorphological research, in general, as well as for phylogenetic reconstructions.
[Mh] Termos MeSH primário: Encéfalo/anatomia & histologia
Bovinos/anatomia & histologia
Imagem por Ressonância Magnética
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Diencéfalo/anatomia & histologia
Mesencéfalo/anatomia & histologia
Metencéfalo/anatomia & histologia
Neuroanatomia
Telencéfalo/anatomia & histologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:0908
[Cu] Atualização por classe:091020
[Lr] Data última revisão:
091020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090106
[St] Status:MEDLINE
[do] DOI:10.1002/jmor.10717


  7 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:18494704
[Au] Autor:Nakamura H; Sato T; Suzuki-Hirano A
[Ad] Endereço:Department of Molecular Neurobiology, Graduate School of Life Sciences, and Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai 980-8575, Japan. nakamura@idac.tohoku.ac.jp
[Ti] Título:Isthmus organizer for mesencephalon and metencephalon.
[So] Source:Dev Growth Differ;50 Suppl 1:S113-8, 2008 Jun.
[Is] ISSN:1440-169X
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The vertebrate central nervous system is elaborated from a simple neural tube. Brain vesicles formation is the first sign of regionalization. Classical transplantation using quail and chick embryos revealed that the mesencephalon-metencephalon boundary (isthmus) functions as an organizer of the mesencephalon and metencephalon. Fgf8 is accepted as a main organizing molecule of the isthmus. Strong Fgf8 signal activates the Ras-ERK signaling pathway to differentiate the cerebellum. In this review, the historical background of the means of identifying the isthmus organizer and the molecular mechanisms of signal transduction for tectum and cerebellum differentiation is reviewed.
[Mh] Termos MeSH primário: Cerebelo/embriologia
Biologia do Desenvolvimento/métodos
Mesencéfalo/fisiologia
Metencéfalo/fisiologia
[Mh] Termos MeSH secundário: Animais
Embrião de Galinha
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Fator 8 de Crescimento de Fibroblasto/metabolismo
Regulação da Expressão Gênica no Desenvolvimento
Mesencéfalo/metabolismo
Metencéfalo/metabolismo
Modelos Anatômicos
Modelos Biológicos
Crista Neural/embriologia
Codorniz
Fatores de Transcrição/metabolismo
Proteínas ras/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Transcription Factors); 148997-75-5 (Fibroblast Growth Factor 8); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 3.6.5.2 (ras Proteins)
[Em] Mês de entrada:0809
[Cu] Atualização por classe:091119
[Lr] Data última revisão:
091119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080617
[St] Status:MEDLINE
[do] DOI:10.1111/j.1440-169X.2008.00995.x


  8 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:17410969
[Au] Autor:Gubler E; Hilbe M; Ehrensperger F
[Ad] Endereço:Institute of Veterinary Pathology, Vetsuisse-Faculty University of Zurich, Switzerland.
[Ti] Título:Lesion profiles and gliosis in the brainstem of 135 Swiss cows with bovine spongiform encephalopathy (BSE).
[So] Source:Schweiz Arch Tierheilkd;149(3):111-22, 2007 Mar.
[Is] ISSN:0036-7281
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Lesion profiles are considered to be an important tool for the comparison of the various animal and human spongiform encephalopathies and to obtain information upon prion strain variations. Histological and immunohistochemical reactions (PrPsc, GFAP) in 13 brain areas at 4 levels in the brainstem from 135 BSE-positive and 45 BSE-negative cases were retrospectively evaluated. In this retrospective study a lesion profile based on histological features was worked out on the basis of BSE cases originating from Switzerland over a period of ten years. They were confirmed post mortem by histology and immunohistology. Our findings were reviewed in comparison with lesion profiles published in England. No striking differences comparing type and quality of lesions in the relevant areas between the Swiss and the English cases were evident. Moreover, the lesion profiles and the character of the lesions did not differ between animals born before or after the offal feeding ban, which supports the hypothesis that the Swiss epidemic is sustained by the same single, stable strain of the BSE agent, which is probably the same as in the English epidemic. There was a good correlation between PrPsc accumulation and spongiform changes, in particular in those areas which were morphologically most affected. Astrocytosis in BSE was quantified. A significant rise in GFAP-positive cells could be shown comparing the brain stem nuclei of BSE affected with BSE-unaffected cattle, despite considerable variation between the cases and between the nuclei. The observed astrocytosis did correlate with vacuolation of the neuropil and of perikarya as well as with PrPsc accumulation.
[Mh] Termos MeSH primário: Encefalopatia Espongiforme Bovina/patologia
Gliose/veterinária
Bulbo/patologia
Mesencéfalo/patologia
Metencéfalo/patologia
[Mh] Termos MeSH secundário: Animais
Anticorpos/metabolismo
Bovinos
Feminino
Proteína Glial Fibrilar Ácida/análise
Proteína Glial Fibrilar Ácida/imunologia
Gliose/patologia
Imuno-Histoquímica/veterinária
Bulbo/química
Mesencéfalo/química
Metencéfalo/química
Proteínas PrPSc/análise
Proteínas PrPSc/imunologia
Estudos Retrospectivos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antibodies); 0 (Glial Fibrillary Acidic Protein); 0 (PrPSc Proteins)
[Em] Mês de entrada:0706
[Cu] Atualização por classe:091103
[Lr] Data última revisão:
091103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:070407
[St] Status:MEDLINE


  9 / 45 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
[PMID]:17034660
[Au] Autor:Pietrzak B; Czarnecka E
[Ad] Endereço:Department of Pharmacodynamics, Medical University of Lódz, Muszynskiego 1, PL 90-151 Lódz, Poland. bpietrzak@pharm.am.lodz.pl
[Ti] Título:Effect of the administration of tiagabine and gabapentin on rabbit electroencephalogram activity.
[So] Source:J Pharm Pharmacol;58(10):1367-72, 2006 Oct.
[Is] ISSN:0022-3573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:New generation antiepileptic drugs, including gabapentin and tiagabine, are used in monotherapy or in combination with other drugs for specific seizure types. The multidirectional mechanism of activity and varied pharmacological properties of these drugs suggest that they could also be used in the therapy of other diseases. A possible limitation of new generation antiepileptic drugs is the incidence of CNS-related adverse effects. Few studies have assessed the effect of new antiepileptic drugs on electroencephalogram (EEG) recordings in subjects using these drugs for diseases other than epilepsy. The aim of this study was to determine the effects of tiagabine and gabapentin on EEG recordings from the midbrain reticular formation, dorsal hippocampus and frontal cortex in rabbits. Tiagabine was administered orally at a single dose of 5 and 20 mg kg(-1), or repeatedly at a dose of 5 mg kg(-1) (twice a day) for 14 days. Gabapentin was administered orally at a single dose of 25 and 100 mg kg(-1), or repeatedly at a dose of 25 mg kg(-1) (twice a day) for 14 days. Both tiagabine and gabapentin caused changes indicative of CNS inhibitory properties, which may be associated with the adverse effects of the drugs. After repeated doses of the drugs, the changes in EEG recordings were less pronounced than after single doses, which may indicate adaptive changes. The hippocampus was found to be the least sensitive to the effect of gabapentin.
[Mh] Termos MeSH primário: Aminas/farmacologia
Anticonvulsivantes/farmacologia
Ácidos Cicloexanocarboxílicos/farmacologia
Eletroencefalografia/efeitos dos fármacos
Ácidos Nipecóticos/farmacologia
Ácido gama-Aminobutírico/farmacologia
[Mh] Termos MeSH secundário: Aminas/administração & dosagem
Animais
Anticonvulsivantes/administração & dosagem
Ácidos Cicloexanocarboxílicos/administração & dosagem
Relação Dose-Resposta a Droga
Feminino
Lobo Frontal/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Masculino
Metencéfalo/efeitos dos fármacos
Ácidos Nipecóticos/administração & dosagem
Coelhos
Ácido gama-Aminobutírico/administração & dosagem
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amines); 0 (Anticonvulsants); 0 (Cyclohexanecarboxylic Acids); 0 (Nipecotic Acids); 56-12-2 (gamma-Aminobutyric Acid); 6CW7F3G59X (gabapentin); Z80I64HMNP (tiagabine)
[Em] Mês de entrada:0701
[Cu] Atualização por classe:130611
[Lr] Data última revisão:
130611
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061013
[St] Status:MEDLINE


  10 / 45 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
[PMID]:16496282
[Au] Autor:Langenberg T; Dracz T; Oates AC; Heisenberg CP; Brand M
[Ad] Endereço:Biotechnology center, University of Technology, Dresden, Germany.
[Ti] Título:Analysis and visualization of cell movement in the developing zebrafish brain.
[So] Source:Dev Dyn;235(4):928-33, 2006 Apr.
[Is] ISSN:1058-8388
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Detailed reconstruction of the spatiotemporal history of embryonic cells is key to understanding tissue formation processes but is often complicated by the large number of cells involved, particularly so in vertebrates. Through a combination of high-resolution time-lapse lineage tracing and antibody staining, we have analyzed the movement of mesencephalic and metencephalic cell populations in the early zebrafish embryo. To facilitate the analysis of our cell tracking data, we have created TracePilot, a software tool that allows interactive manipulation and visualization of tracking data. We demonstrate its utility by showing novel visualizations of cell movement in the developing zebrafish brain. TracePilot (http://www.mpi-cbg.de/tracepilot) is Java-based, available free of charge, and has a program structure that allows the incorporation of additional analysis tools.
[Mh] Termos MeSH primário: Movimento Celular
Mesencéfalo/citologia
Mesencéfalo/embriologia
Metencéfalo/citologia
Metencéfalo/embriologia
Peixe-Zebra/embriologia
[Mh] Termos MeSH secundário: Animais
Linhagem da Célula
Gráficos por Computador
Interpretação Estatística de Dados
Embrião não Mamífero
Mesencéfalo/fisiologia
Metencéfalo/fisiologia
Microscopia de Vídeo
Software
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:0606
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060224
[St] Status:MEDLINE



página 1 de 5 ir para página              
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde