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[PMID]:29353037
[Au] Autor:Lu Z; Liu Y; Shi Y; Shi X; Wang X; Xu C; Zhao H; Dong Q
[Ad] Endereço:Department of Neurology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, PR China.
[Ti] Título:Curcumin protects cortical neurons against oxygen and glucose deprivation/reoxygenation injury through flotillin-1 and extracellular signal-regulated kinase1/2 pathway.
[So] Source:Biochem Biophys Res Commun;496(2):515-522, 2018 02 05.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this study, we provided evidence that curcumin could be a promising therapeutic agent for ischemic stroke by activating neuroprotective signaling pathways. Post oxygen and glucose deprivation/reoxygenation (OGD/R), primary mouse cortical neurons treated with curcumin exhibited a significant decrease in cell death, LDH release and enzyme caspase-3 activity under OGD/R circumstances, which were abolished by flotillin-1 downregulation or extracellular signal-regulated kinase (ERK) inhibitor. Moreover, flotillin-1 knockdown led to suppression of curcumin-mediated ERK phosphorylation under OGD/R condition. Based on these findings, we concluded that curcumin could confer neuroprotection against OGD/R injury through a novel flotillin-1 and ERK1/2 pathway.
[Mh] Termos MeSH primário: Isquemia Encefálica/tratamento farmacológico
Curcumina/farmacologia
Sistema de Sinalização das MAP Quinases/efeitos dos fármacos
Proteínas de Membrana/metabolismo
Neurônios/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Animais
Isquemia Encefálica/metabolismo
Células Cultivadas
Córtex Cerebelar/citologia
Córtex Cerebelar/efeitos dos fármacos
Feminino
Glucose/metabolismo
Masculino
Camundongos Endogâmicos BALB C
Neurônios/metabolismo
Oxigênio/metabolismo
Traumatismo por Reperfusão/tratamento farmacológico
Traumatismo por Reperfusão/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (Neuroprotective Agents); 0 (flotillins); IT942ZTH98 (Curcumin); IY9XDZ35W2 (Glucose); S88TT14065 (Oxygen)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180309
[Lr] Data última revisão:
180309
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180122
[St] Status:MEDLINE


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[PMID]:28461661
[Au] Autor:Hull C
[Ad] Endereço:Department of Neurobiology, Duke University, Durham, North Carolina 27710 Hull@neuro.duke.edu.
[Ti] Título:Measuring Feedforward Inhibition and Its Impact on Local Circuit Function.
[So] Source:Cold Spring Harb Protoc;2017(5):pdb.prot095828, 2017 May 01.
[Is] ISSN:1559-6095
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This protocol describes a series of approaches to measure feedforward inhibition in acute brain slices from the cerebellar cortex. Using whole-cell voltage and current clamp recordings from Purkinje cells in conjunction with electrical stimulation of the parallel fibers, these methods demonstrate how to measure the relationship between excitation and inhibition in a feedforward circuit. This protocol also describes how to measure the impact of feedforward inhibition on Purkinje cell excitability, with an emphasis on spike timing.
[Mh] Termos MeSH primário: Córtex Cerebelar/fisiologia
Fenômenos Eletrofisiológicos/fisiologia
[Mh] Termos MeSH secundário: Animais
Estimulação Elétrica
Potenciais Evocados/fisiologia
Potenciais da Membrana/fisiologia
Técnicas de Patch-Clamp
Células de Purkinje/fisiologia
Sinapses/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE
[do] DOI:10.1101/pdb.prot095828


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[PMID]:28934196
[Au] Autor:Sudhakar SK; Hong S; Raikov I; Publio R; Lang C; Close T; Guo D; Negrello M; De Schutter E
[Ad] Endereço:Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Onna-son, Okinawa, Japan.
[Ti] Título:Spatiotemporal network coding of physiological mossy fiber inputs by the cerebellar granular layer.
[So] Source:PLoS Comput Biol;13(9):e1005754, 2017 Sep.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The granular layer, which mainly consists of granule and Golgi cells, is the first stage of the cerebellar cortex and processes spatiotemporal information transmitted by mossy fiber inputs with a wide variety of firing patterns. To study its dynamics at multiple time scales in response to inputs approximating real spatiotemporal patterns, we constructed a large-scale 3D network model of the granular layer. Patterned mossy fiber activity induces rhythmic Golgi cell activity that is synchronized by shared parallel fiber input and by gap junctions. This leads to long distance synchrony of Golgi cells along the transverse axis, powerfully regulating granule cell firing by imposing inhibition during a specific time window. The essential network mechanisms, including tunable Golgi cell oscillations, on-beam inhibition and NMDA receptors causing first winner keeps winning of granule cells, illustrate how fundamental properties of the granule layer operate in tandem to produce (1) well timed and spatially bound output, (2) a wide dynamic range of granule cell firing and (3) transient and coherent gating oscillations. These results substantially enrich our understanding of granule cell layer processing, which seems to promote spatial group selection of granule cell activity as a function of timing of mossy fiber input.
[Mh] Termos MeSH primário: Relógios Biológicos/fisiologia
Córtex Cerebelar/fisiologia
Modelos Neurológicos
Fibras Nervosas/fisiologia
Rede Nervosa/fisiologia
Análise Espaço-Temporal
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Simulação por Computador
Seres Humanos
Transmissão Sináptica/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171018
[Lr] Data última revisão:
171018
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170922
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005754


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[PMID]:28792528
[Au] Autor:Moroso A; Ruet A; Lamargue-Hamel D; Munsch F; Deloire M; Coupé P; Charré-Morin J; Saubusse A; Ouallet JC; Planche V; Tourdias T; Dousset V; Brochet B
[Ad] Endereço:Univ. Bordeaux, Bordeaux, France.
[Ti] Título:Microstructural analyses of the posterior cerebellar lobules in relapsing-onset multiple sclerosis and their implication in cognitive impairment.
[So] Source:PLoS One;12(8):e0182479, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The posterior cerebellar lobules seem to be the anatomical substrate of cognitive cerebellar processes, but their microstructural alterations in multiple sclerosis (MS) remain unclear. OBJECTIVES: To correlate diffusion metrics in lobules VI to VIIIb in persons with clinically isolated syndrome (PwCIS) and in cognitively impaired persons with MS (CIPwMS) with their cognitive performances. METHODS: Sixty-nine patients (37 PwCIS, 32 CIPwMS) and 36 matched healthy subjects (HS) underwent 3T magnetic resonance imaging, including 3D T1-weighted and diffusion tensor imaging (DTI). Fractional anisotropy (FA) and mean diffusivity (MD) were calculated within each lobule and in the cerebellar peduncles. We investigated the correlations between cognitive outcomes and the diffusion parameters of cerebellar sub-structures and performed multiple linear regression analysis to predict cognitive disability. RESULTS: FA was generally lower and MD was higher in the cerebellum and specifically in the vermis Crus II, lobules VIIb and VIIIb in CIPwMS compared with PwCIS and HS. In hierarchical regression analyses, 31% of the working memory z score variance was explained by FA in the left lobule VI and in the left superior peduncle. Working memory was also associated with MD in the vermis Crus II. FA in the left lobule VI and right VIIIa predicted part of the information processing speed (IPS) z scores. CONCLUSION: DTI indicators of cerebellar microstructural damage were associated with cognitive deficits in MS. Our results suggested that cerebellar lobular alterations have an impact on attention, working memory and IPS.
[Mh] Termos MeSH primário: Córtex Cerebelar/diagnóstico por imagem
Disfunção Cognitiva/diagnóstico por imagem
Esclerose Múltipla Recidivante-Remitente/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Disfunção Cognitiva/complicações
Imagem de Tensor de Difusão
Avaliação da Deficiência
Escolaridade
Feminino
Seres Humanos
Interpretação de Imagem Assistida por Computador
Imagem Tridimensional
Modelos Lineares
Imagem por Ressonância Magnética
Masculino
Memória de Curto Prazo
Meia-Idade
Esclerose Múltipla Recidivante-Remitente/complicações
Esclerose Múltipla Recidivante-Remitente/psicologia
Análise Multivariada
Testes Neuropsicológicos
Prognóstico
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170810
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182479


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[PMID]:28658323
[Au] Autor:Amat SB; Rowan MJM; Gaffield MA; Bonnan A; Kikuchi C; Taniguchi H; Christie JM
[Ad] Endereço:Max Planck Florida Institute for Neuroscience, Jupiter, FL, United States of America.
[Ti] Título:Using c-kit to genetically target cerebellar molecular layer interneurons in adult mice.
[So] Source:PLoS One;12(6):e0179347, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The cerebellar system helps modulate and fine-tune motor action. Purkinje cells (PCs) provide the sole output of the cerebellar cortex, therefore, any cerebellar involvement in motor activity must be driven by changes in PC firing rates. Several different cell types influence PC activity including excitatory input from parallel fibers and inhibition from molecular layer interneurons (MLIs). Similar to PCs, MLI activity is driven by parallel fibers, therefore, MLIs provide feed-forward inhibition onto PCs. To aid in the experimental assessment of how molecular layer inhibition contributes to cerebellar function and motor behavior, we characterized a new knock-in mouse line with Cre recombinase expression under control of endogenous c-kit transcriptional machinery. Using these engineered c-Kit mice, we were able to obtain high levels of conditional MLI transduction in adult mice using Cre-dependent viral vectors without any PC or granule cell labeling. We then used the mouse line to target MLIs for activity perturbation in vitro using opto- and chemogenetics.
[Mh] Termos MeSH primário: Córtex Cerebelar/citologia
Cerebelo/citologia
Interneurônios/citologia
Proteínas Proto-Oncogênicas c-kit/metabolismo
[Mh] Termos MeSH secundário: Potenciais de Ação/fisiologia
Animais
Córtex Cerebelar/metabolismo
Cerebelo/metabolismo
Interneurônios/metabolismo
Camundongos
Camundongos Transgênicos
Proteínas Proto-Oncogênicas c-kit/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.10.1 (Proto-Oncogene Proteins c-kit)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170629
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0179347


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[PMID]:28648497
[Au] Autor:El-Shamayleh Y; Kojima Y; Soetedjo R; Horwitz GD
[Ad] Endereço:Department of Physiology & Biophysics, University of Washington, 1959 NE Pacific St., HSB I-728, UW Mailbox 357290, Seattle, WA 98195, USA; Washington National Primate Research Center, University of Washington, 1959 NE Pacific St., HSB I-728, UW Mailbox 357290, Seattle, WA 98195, USA.
[Ti] Título:Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum.
[So] Source:Neuron;95(1):51-62.e4, 2017 Jul 05.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purkinje cells of the primate cerebellum play critical but poorly understood roles in the execution of coordinated, accurate movements. Elucidating these roles has been hampered by a lack of techniques for manipulating spiking activity in these cells selectively-a problem common to most cell types in non-transgenic animals. To overcome this obstacle, we constructed AAV vectors carrying the channelrhodopsin-2 (ChR2) gene under the control of a 1 kb L7/Pcp2 promoter. We injected these vectors into the cerebellar cortex of rhesus macaques and tested vector efficacy in three ways. Immunohistochemical analyses confirmed selective ChR2 expression in Purkinje cells. Neurophysiological recordings confirmed robust optogenetic activation. Optical stimulation of the oculomotor vermis caused saccade dysmetria. Our results demonstrate the utility of AAV-L7-ChR2 for revealing the contributions of Purkinje cells to circuit function and behavior, and they attest to the feasibility of promoter-based, targeted, genetic manipulations in primates.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Vermis Cerebelar/fisiologia
Optogenética/métodos
Células de Purkinje/fisiologia
Movimentos Sacádicos/fisiologia
[Mh] Termos MeSH secundário: Animais
Córtex Cerebelar/citologia
Córtex Cerebelar/fisiologia
Vermis Cerebelar/citologia
Cerebelo/citologia
Cerebelo/fisiologia
Dependovirus/genética
Medições dos Movimentos Oculares
Imuno-Histoquímica
Macaca mulatta
Células de Purkinje/citologia
Células de Purkinje/metabolismo
Rodopsina/genética
Rodopsina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9009-81-8 (Rhodopsin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


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[PMID]:28574396
[Au] Autor:Grintsova N; Glushchenko N; Dunaeva M
[Ad] Endereço:Sumy State University, Department of Normal Anatomy, Department of Biophysics, Biochemistry, Pharmacology and Biomolecular Engineering, Ukraine.
[Ti] Título:COMPLEX HEAVY METAL SALTS' EFFECT ON GANGLION NUCLEI NEURONS MORPHOLOGICAL FUNCTIONS IN ADULT MALE RATS' CEREBELLAR CORTEX.
[So] Source:Georgian Med News;(265):125-130, 2017 Apr.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:In order to analyze the dynamics of morphological and morphometric nuclear rearrangements of cortical cerebellar Purkinje cells under prolonged exposure (for 90 days) on the body of copper sulfate, zinc and iron experiment was conducted on 48 white adult male rats weighing 200-250g, aged 5 -8 months. We used anatomic, morphometric, statistical and common methods of micro anatomical research method. It was found that the combined effect of copper sulfate, zinc and iron on the body has nuclear device ganglion neurons in the cerebellar cortex sufficiently expressive toxicity, which affects the state of neurons. The degree of morphological rearrangements in the nuclear unit is in direct proportion to the duration of the experiment. In the nuclei of ganglion neurons develop nonspecific changes of polymorphic nature, which is reversible in the early stages of experience and irreversible, mainly necrobiotic character (chromatolysis, pycnosis and reksis) in most of the neurons within a timeline.
[Mh] Termos MeSH primário: Córtex Cerebelar/efeitos dos fármacos
Sulfato de Cobre/toxicidade
Compostos Ferrosos/toxicidade
Células de Purkinje/efeitos dos fármacos
Poluentes do Solo/toxicidade
Poluentes Químicos da Água/toxicidade
Sulfato de Zinco/toxicidade
[Mh] Termos MeSH secundário: Animais
Núcleo Celular/efeitos dos fármacos
Núcleo Celular/ultraestrutura
Córtex Cerebelar/patologia
Masculino
Células de Purkinje/patologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ferrous Compounds); 0 (Soil Pollutants); 0 (Water Pollutants, Chemical); 39R4TAN1VT (ferrous sulfate); 7733-02-0 (Zinc Sulfate); LRX7AJ16DT (Copper Sulfate)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171110
[Lr] Data última revisão:
171110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170603
[St] Status:MEDLINE


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[PMID]:28408971
[Au] Autor:Markovic B; Radonjic NV; Jevtic G; Stojkovic T; Velimirovic M; Aksic M; Poleksic J; Nikolic T; Aleksic D; Radonjic V; Filipovic B; Petronijevic ND
[Ad] Endereço:Faculty of Sport and Physical Education, University of Belgrade, Blagoja Parovica 156, Belgrade, Serbia.
[Ti] Título:Long-Term Effects of Maternal Deprivation on Redox Regulation in Rat Brain: Involvement of NADPH Oxidase.
[So] Source:Oxid Med Cell Longev;2017:7390516, 2017.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Maternal deprivation (MD) causes perinatal stress, with subsequent behavioral changes which resemble the symptoms of schizophrenia. The NADPH oxidase is one of the major generators of reactive oxygen species, known to play a role in stress response in different tissues. The aim of this study was to elucidate the long-term effects of MD on the expression of NADPH oxidase subunits (gp91 , p22 , p67 , p47 , and p40 ). Activities of cytochrome C oxidase and respiratory chain Complex I, as well as the oxidative stress parameters using appropriate spectrophotometric techniques were analyzed. Nine-day-old Wistar rats were exposed to a 24 h maternal deprivation and sacrificed at young adult age. The structures affected by perinatal stress, cortex, hippocampus, thalamus, and caudate nuclei were investigated. The most prominent findings were increased expressions of gp91 in the cortex and hippocampus, increased expression of p22 and p40 , and decreased expression of gp91 , p22 , and p47 in the caudate nuclei. Complex I activity was increased in all structures except cortex. Content of reduced glutathione was decreased in all sections while region-specific changes of other oxidative stress parameters were found. Our results indicate the presence of long-term redox alterations in MD rats.
[Mh] Termos MeSH primário: Encéfalo/metabolismo
NADPH Oxidases/metabolismo
[Mh] Termos MeSH secundário: Animais
Núcleo Caudado/metabolismo
Córtex Cerebelar/metabolismo
Regulação para Baixo
Complexo I de Transporte de Elétrons/metabolismo
Complexo IV da Cadeia de Transporte de Elétrons/metabolismo
Hipocampo/metabolismo
Privação Materna
Glicoproteínas de Membrana/metabolismo
NADPH Oxidase 2
Oxirredução
Estresse Oxidativo
Fosfoproteínas/metabolismo
Ratos
Ratos Wistar
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Glycoproteins); 0 (Phosphoproteins); 0 (neutrophil cytosol factor 40K); EC 1.6.3.- (Cybb protein, rat); EC 1.6.3.- (NADPH Oxidase 2); EC 1.6.3.- (NADPH Oxidases); EC 1.6.3.1 (p22-phox protein, rat); EC 1.6.5.3 (Electron Transport Complex I); EC 1.9.3.1 (Electron Transport Complex IV)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE
[do] DOI:10.1155/2017/7390516


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[PMID]:28334963
[Au] Autor:Nakai Y; Jeong JW; Brown EC; Rothermel R; Kojima K; Kambara T; Shah A; Mittal S; Sood S; Asano E
[Ad] Endereço:Department of Pediatrics, Wayne State University, Children's Hospital of Michigan, Detroit Medical Center, Detroit, MI, 48201, USA.
[Ti] Título:Three- and four-dimensional mapping of speech and language in patients with epilepsy.
[So] Source:Brain;140(5):1351-1370, 2017 05 01.
[Is] ISSN:1460-2156
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have provided 3-D and 4D mapping of speech and language function based upon the results of direct cortical stimulation and event-related modulation of electrocorticography signals. Patients estimated to have right-hemispheric language dominance were excluded. Thus, 100 patients who underwent two-stage epilepsy surgery with chronic electrocorticography recording were studied. An older group consisted of 84 patients at least 10 years of age (7367 artefact-free non-epileptic electrodes), whereas a younger group included 16 children younger than age 10 (1438 electrodes). The probability of symptoms transiently induced by electrical stimulation was delineated on a 3D average surface image. The electrocorticography amplitude changes of high-gamma (70-110 Hz) and beta (15-30 Hz) activities during an auditory-naming task were animated on the average surface image in a 4D manner. Thereby, high-gamma augmentation and beta attenuation were treated as summary measures of cortical activation. Stimulation data indicated the causal relationship between (i) superior-temporal gyrus of either hemisphere and auditory hallucination; (ii) left superior-/middle-temporal gyri and receptive aphasia; (iii) widespread temporal/frontal lobe regions of the left hemisphere and expressive aphasia; and (iv) bilateral precentral/left posterior superior-frontal regions and speech arrest. On electrocorticography analysis, high-gamma augmentation involved the bilateral superior-temporal and precentral gyri immediately following question onset; at the same time, high-gamma activity was attenuated in the left orbitofrontal gyrus. High-gamma activity was augmented in the left temporal/frontal lobe regions, as well as left inferior-parietal and cingulate regions, maximally around question offset, with high-gamma augmentation in the left pars orbitalis inferior-frontal, middle-frontal, and inferior-parietal regions preceded by high-gamma attenuation in the contralateral homotopic regions. Immediately before verbal response, high-gamma augmentation involved the posterior superior-frontal and pre/postcentral regions, bilaterally. Beta-attenuation was spatially and temporally correlated with high-gamma augmentation in general but with exceptions. The younger and older groups shared similar spatial-temporal profiles of high-gamma and beta modulation; except, the younger group failed to show left-dominant activation in the rostral middle-frontal and pars orbitalis inferior-frontal regions around stimulus offset. The human brain may rapidly and alternately activate and deactivate cortical areas advantageous or obtrusive to function directed toward speech and language at a given moment. Increased left-dominant activation in the anterior frontal structures in the older age group may reflect developmental consolidation of the language system. The results of our functional mapping may be useful in predicting, across not only space but also time and patient age, sites specific to language function for presurgical evaluation of focal epilepsy.
[Mh] Termos MeSH primário: Mapeamento Encefálico/métodos
Córtex Cerebelar/fisiologia
Eletrocorticografia/métodos
Epilepsia/fisiopatologia
Imagem Tridimensional/métodos
Linguagem
Fala/fisiologia
[Mh] Termos MeSH secundário: Adolescente
Adulto
Fatores Etários
Ondas Encefálicas/fisiologia
Criança
Pré-Escolar
Estimulação Elétrica
Eletrodos Implantados
Seres Humanos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170324
[St] Status:MEDLINE
[do] DOI:10.1093/brain/awx051


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[PMID]:28272153
[Au] Autor:Silva S; Peran P; Kerhuel L; Malagurski B; Chauveau N; Bataille B; Lotterie JA; Celsis P; Aubry F; Citerio G; Jean B; Chabanne R; Perlbarg V; Velly L; Galanaud D; Vanhaudenhuyse A; Fourcade O; Laureys S; Puybasset L
[Ad] Endereço:1Department of Anaesthesiology and Critical Care, Critical Care Unit, University Teaching Hospital of Purpan, Place du Dr Baylac, Toulouse Cedex 9, France.2Critical Care and Anaesthesiology Department, University Teaching Hospital of Purpan, Place du Dr Baylac, Toulouse Cedex 9, France.3Toulouse NeuroImaging Center, Toulouse University, Inserm, UPS, France.4Department of Anaesthesiology and Critical Care, Critical Care Unit, Hopital Dieu Hospital, Narbonne, France.5Department of Anaesthesiology and Critical Care, School of medicine and Surgery, University Milano Bicocca and Hospital San Gerardo, Monza, Italy.6Department of Neuroradiology, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.7Department of Anaesthesiology and Critical Care, University Hospital of Clermont-Ferrand, Clermont-Ferrand, France.8Laboratoire d'Imagerie Biomédicale (UMR S 1146/UMR 7371), Université Pierre-et-Marie-Curie-Paris 06, Paris, France.9Critical Care and Anaesthesiology Department, Groupe Hospitalier Pitié-Salpétrière, APHP, Paris, France.10Department of Neuroradiology, Groupe Hospitalier Pitié-Salpétrière, APHP, Paris, France.11Cyclotron Research Center and Department of Neurology, University Hospital and University of Liège, Liège, Belgium.12Algology and Palliative Care Department, University Hospital and University of Liège, Liège, Belgium.
[Ti] Título:Brain Gray Matter MRI Morphometry for Neuroprognostication After Cardiac Arrest.
[So] Source:Crit Care Med;45(8):e763-e771, 2017 Aug.
[Is] ISSN:1530-0293
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: We hypothesize that the combined use of MRI cortical thickness measurement and subcortical gray matter volumetry could provide an early and accurate in vivo assessment of the structural impact of cardiac arrest and therefore could be used for long-term neuroprognostication in this setting. DESIGN: Prospective cohort study. SETTING: Five Intensive Critical Care Units affiliated to the University in Toulouse (France), Paris (France), Clermont-Ferrand (France), Liège (Belgium), and Monza (Italy). PATIENTS: High-resolution anatomical T1-weighted images were acquired in 126 anoxic coma patients ("learning" sample) 16 ± 8 days after cardiac arrest and 70 matched controls. An additional sample of 18 anoxic coma patients, recruited in Toulouse, was used to test predictive model generalization ("test" sample). All patients were followed up 1 year after cardiac arrest. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Cortical thickness was computed on the whole cortical ribbon, and deep gray matter volumetry was performed after automatic segmentation. Brain morphometric data were employed to create multivariate predictive models using learning machine techniques. Patients displayed significantly extensive cortical and subcortical brain volumes atrophy compared with controls. The accuracy of a predictive classifier, encompassing cortical and subcortical components, has a significant discriminative power (learning area under the curve = 0.87; test area under the curve = 0.96). The anatomical regions which volume changes were significantly related to patient's outcome were frontal cortex, posterior cingulate cortex, thalamus, putamen, pallidum, caudate, hippocampus, and brain stem. CONCLUSIONS: These findings are consistent with the hypothesis of pathologic disruption of a striatopallidal-thalamo-cortical mesocircuit induced by cardiac arrest and pave the way for the use of combined brain quantitative morphometry in this setting.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Encéfalo/patologia
Parada Cardíaca/patologia
[Mh] Termos MeSH secundário: Adulto
Córtex Cerebelar/diagnóstico por imagem
Córtex Cerebelar/patologia
Coma/diagnóstico por imagem
Coma/patologia
Feminino
Substância Cinzenta/diagnóstico por imagem
Substância Cinzenta/patologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Prognóstico
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170816
[Lr] Data última revisão:
170816
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170309
[St] Status:MEDLINE
[do] DOI:10.1097/CCM.0000000000002379



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