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[PMID]:28648497
[Au] Autor:El-Shamayleh Y; Kojima Y; Soetedjo R; Horwitz GD
[Ad] Endereço:Department of Physiology & Biophysics, University of Washington, 1959 NE Pacific St., HSB I-728, UW Mailbox 357290, Seattle, WA 98195, USA; Washington National Primate Research Center, University of Washington, 1959 NE Pacific St., HSB I-728, UW Mailbox 357290, Seattle, WA 98195, USA.
[Ti] Título:Selective Optogenetic Control of Purkinje Cells in Monkey Cerebellum.
[So] Source:Neuron;95(1):51-62.e4, 2017 Jul 05.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purkinje cells of the primate cerebellum play critical but poorly understood roles in the execution of coordinated, accurate movements. Elucidating these roles has been hampered by a lack of techniques for manipulating spiking activity in these cells selectively-a problem common to most cell types in non-transgenic animals. To overcome this obstacle, we constructed AAV vectors carrying the channelrhodopsin-2 (ChR2) gene under the control of a 1 kb L7/Pcp2 promoter. We injected these vectors into the cerebellar cortex of rhesus macaques and tested vector efficacy in three ways. Immunohistochemical analyses confirmed selective ChR2 expression in Purkinje cells. Neurophysiological recordings confirmed robust optogenetic activation. Optical stimulation of the oculomotor vermis caused saccade dysmetria. Our results demonstrate the utility of AAV-L7-ChR2 for revealing the contributions of Purkinje cells to circuit function and behavior, and they attest to the feasibility of promoter-based, targeted, genetic manipulations in primates.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Vermis Cerebelar/fisiologia
Optogenética/métodos
Células de Purkinje/fisiologia
Movimentos Sacádicos/fisiologia
[Mh] Termos MeSH secundário: Animais
Córtex Cerebelar/citologia
Córtex Cerebelar/fisiologia
Vermis Cerebelar/citologia
Cerebelo/citologia
Cerebelo/fisiologia
Dependovirus/genética
Medições dos Movimentos Oculares
Imuno-Histoquímica
Macaca mulatta
Células de Purkinje/citologia
Células de Purkinje/metabolismo
Rodopsina/genética
Rodopsina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
9009-81-8 (Rhodopsin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170810
[Lr] Data última revisão:
170810
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170627
[St] Status:MEDLINE


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[PMID]:28371302
[Au] Autor:Podolska A; Kobelt A; Fuchs S; Hackmann K; Rump A; Schröck E; Kutsche K; Di Donato N
[Ad] Endereço:Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[Ti] Título:Functional monosomy of 6q27-qter and functional disomy of Xpter-p22.11 due to X;6 translocation with an atypical X-inactivation pattern.
[So] Source:Am J Med Genet A;173(5):1334-1341, 2017 May.
[Is] ISSN:1552-4833
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pattern of X chromosome inactivation (XCI) is typically random in females. However, chromosomal rearrangements affecting the X chromosome can result in XCI skewing due to cell growth disadvantage. In case of an X;autosome translocation, this usually leads to an XCI pattern of 100:0 with the derivative X being the active one in the majority of females. A de novo balanced X;6 translocation [46,X,t(X;6)(p22.1;q27)] and a completely skewed XCI pattern (100:0) were detected in a female patient with microcephaly, cerebellar vermis hypoplasia, heart defect, and severe developmental delay. We mapped the breakpoint regions using fluorescence in situ hybridization and found the X-linked gene POLA1 to be disrupted. POLA1 codes for the catalytic subunit of the polymerase α-primase complex which is responsible for initiation of the DNA replication process; absence of POLA1 is probably incompatible with life. Consequently, by RBA banding we determined which of the X chromosomes was the active one in the patient. In all examined lymphocytes the wild-type X chromosome was active. We propose that completely skewed XCI favoring the normal X chromosome resulted from death of cells with an active derivative X that was caused by a non-functional POLA1 gene. In summary, we conclude that functional monosomy of 6q27-qter and functional disomy of Xpter-p22.11 are responsible for the clinical phenotype of the patient. This case demonstrates the importance of determining which one of the X chromosomes underwent inactivation to correlate clinical features of a female with an X;autosome translocation with the nature of the genetic alteration.
[Mh] Termos MeSH primário: Cromossomos Humanos X/genética
DNA Polimerase III/genética
Deficiências do Desenvolvimento/genética
Microcefalia/genética
Inativação do Cromossomo X/genética
[Mh] Termos MeSH secundário: Adulto
Vermis Cerebelar/fisiopatologia
Cromossomos Humanos Par 6/genética
Deficiências do Desenvolvimento/fisiopatologia
Feminino
Genes Ligados ao Cromossomo X
Genótipo
Seres Humanos
Hibridização in Situ Fluorescente
Microcefalia/fisiopatologia
Monossomia/genética
Fenótipo
Translocação Genética/genética
Dissomia Uniparental/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 2.7.7.- (DNA Polymerase III); EC 2.7.7.- (DNA polymerase A)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170508
[Lr] Data última revisão:
170508
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170404
[St] Status:MEDLINE
[do] DOI:10.1002/ajmg.a.38183


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[PMID]:28196488
[Au] Autor:Zhang J; Al-Nahari F; Wang ZF; Lin FH; Zhao YY; Xiao SY; Liu JM; Ke C; Chen ZH; Jiang Y; Yang M; Sai K; Wang J; Mou YG
[Ad] Endereço:Department of Neurosurgery, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Collaborative Innovation, Center for Cancer Medicine, 651 Dong Feng East Road, Guangzhou, 510060, China.
[Ti] Título:Application of fluorescein sodium in the resection of vermis pilocytic astrocytomas.
[So] Source:World J Surg Oncol;15(1):46, 2017 Feb 14.
[Is] ISSN:1477-7819
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Pilocytic astrocytomas (PAs) are slow growing neoplasms and usually located at the cerebellum. There has been certainty regarding the truthful benefit of surgical resection for patients with PA. Gross total resection (GTR) of PAs, especially those being situated in deep regions, remains a surgical challenge. Generally, they are considered as benign and usually develop in young patients. PAs, belonging to WHO I can be cured by radical resection. The patients with PA have excellent prognosis if complete resection can be conducted. The use of fluorescein in vermis PA surgery has not been yet reported. Our data presents fluorescein facilitates surgical resection of vermis PA. METHODS: Five milligrams per kilogram of fluorescein sodium was intravenously injected directly before general anesthesia for the three patients with PA. The yellow 560 filter was employed for microsurgical tumor resection. Surgical outcomes were assessed concerning the extent of resection. RESULTS: Most portion of PA in the three cases was found to be highly fluorescent after intravenous fluorescein sodium injection, which markedly enhanced tumor visibility. Gross total resection in all of the patients was achieved without further neurological deficits. No adverse effects and complications resulting from fluorescein sodium were observed over the postoperative course. CONCLUSIONS: Intraoperative guidance by fluorescein sodium as a new, simple, safe, and practical procedure can enhance the fidelity of tumor tissue and increase the possibility of completely resecting PAs.
[Mh] Termos MeSH primário: Astrocitoma/cirurgia
Neoplasias Encefálicas/cirurgia
Vermis Cerebelar/cirurgia
Meios de Contraste/metabolismo
Fluoresceína/metabolismo
[Mh] Termos MeSH secundário: Astrocitoma/diagnóstico por imagem
Astrocitoma/patologia
Neoplasias Encefálicas/diagnóstico por imagem
Neoplasias Encefálicas/patologia
Vermis Cerebelar/diagnóstico por imagem
Vermis Cerebelar/patologia
Seres Humanos
Imagem por Ressonância Magnética/métodos
Procedimentos Neurocirúrgicos
Prognóstico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); TPY09G7XIR (Fluorescein)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170216
[St] Status:MEDLINE
[do] DOI:10.1186/s12957-017-1108-5


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[PMID]:27709302
[Au] Autor:Tejada-Meza H; Modrego PJ
[Ad] Endereço:Department of Neurology, Hospital Miguel Servet, 50009, Saragossa, Spain.
[Ti] Título:Cerebellar vermis: a vulnerable location of remote brain haemorrhages after thrombolysis for ischaemic stroke.
[So] Source:Neurol Sci;38(1):185-187, 2017 Jan.
[Is] ISSN:1590-3478
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Extra-ischaemic (remote) brain heamorrhages after thrombolysis for ischaemic stroke occur in less than 3 % of treated patients, but it worsens prognosis. Little attention has been paid to the location of the haematomas. Among 12 patients with remote brain haemorrhage after thrombolysis, we report three patients with haemorrhage in the cerebellar vermis (25 %), with poor outcome. Previous hypertensive vasculopathy is deemed to be the most plausible cause.
[Mh] Termos MeSH primário: Isquemia Encefálica/tratamento farmacológico
Vermis Cerebelar/patologia
Fibrinolíticos/efeitos adversos
Hemorragias Intracranianas/induzido quimicamente
Acidente Vascular Cerebral/tratamento farmacológico
Terapia Trombolítica/efeitos adversos
Ativador de Plasminogênio Tecidual/efeitos adversos
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Isquemia Encefálica/diagnóstico por imagem
Isquemia Encefálica/patologia
Vermis Cerebelar/diagnóstico por imagem
Feminino
Fibrinolíticos/uso terapêutico
Seres Humanos
Hemorragias Intracranianas/diagnóstico por imagem
Hemorragias Intracranianas/patologia
Masculino
Meia-Idade
Acidente Vascular Cerebral/diagnóstico por imagem
Acidente Vascular Cerebral/patologia
Ativador de Plasminogênio Tecidual/uso terapêutico
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fibrinolytic Agents); EC 3.4.21.68 (Tissue Plasminogen Activator)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161007
[St] Status:MEDLINE
[do] DOI:10.1007/s10072-016-2728-1


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[PMID]:27056728
[Au] Autor:Nedelescu H; Chowdhury TG; Wable GS; Arbuthnott G; Aoki C
[Ad] Endereço:Department of Systems Neurophysiology, Tokyo Medical and Dental University Graduate School, 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8519, Japan. hn435@nyu.edu.
[Ti] Título:Cerebellar sub-divisions differ in exercise-induced plasticity of noradrenergic axons and in their association with resilience to activity-based anorexia.
[So] Source:Brain Struct Funct;222(1):317-339, 2017 Jan.
[Is] ISSN:1863-2661
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The vermis or "spinocerebellum" receives input from the spinal cord and motor cortex for controlling balance and locomotion, while the longitudinal hemisphere region or "cerebro-cerebellum" is interconnected with non-motor cortical regions, including the prefrontal cortex that underlies decision-making. Noradrenaline release in the cerebellum is known to be important for motor plasticity but less is known about plasticity of the cerebellar noradrenergic (NA) system, itself. We characterized plasticity of dopamine ß-hydroxylase-immunoreactive NA fibers in the cerebellum of adolescent female rats that are evoked by voluntary wheel running, food restriction (FR) or by both, in combination. When 8 days of wheel access was combined with FR during the last 4 days, some responded with excessive exercise, choosing to run even during the hours of food access: this exacerbated weight loss beyond that due to FR alone. In the vermis, exercise, with or without FR, shortened the inter-varicosity intervals and increased varicosity density along NA fibers, while excessive exercise, due to FR, also shortened NA fibers. In contrast, the hemisphere required the FR-evoked excessive exercise to evoke shortened inter-varicosity intervals along NA fibers and this change was exhibited more strongly by rats that suppressed the FR-evoked excessive exercise, a behavior that minimized weight loss. Presuming that shortened inter-varicosity intervals translate to enhanced NA release and synthesis of norepinephrine, this enhancement in the cerebellar hemisphere may contribute towards protection of individuals from the life-threatening activity-based anorexia via relays with higher-order cortical areas that mediate the animal's decision to suppress the innate FR-evoked hyperactivity.
[Mh] Termos MeSH primário: Neurônios Adrenérgicos/citologia
Neurônios Adrenérgicos/fisiologia
Anorexia/patologia
Anorexia/fisiopatologia
Cerebelo/citologia
Cerebelo/fisiologia
Atividade Motora
Plasticidade Neuronal
[Mh] Termos MeSH secundário: Animais
Vermis Cerebelar/citologia
Vermis Cerebelar/fisiologia
Modelos Animais de Doenças
Dopamina/fisiologia
Dopamina beta-Hidroxilase/metabolismo
Ingestão de Alimentos
Feminino
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 1.14.17.1 (Dopamine beta-Hydroxylase); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160409
[St] Status:MEDLINE
[do] DOI:10.1007/s00429-016-1220-2


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[PMID]:26780373
[Au] Autor:Colnaghi S; Honeine JL; Sozzi S; Schieppati M
[Ad] Endereço:Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Via Forlanini 2, 27100, Pavia, Italy. silvia.colnaghi@unipv.it.
[Ti] Título:Body Sway Increases After Functional Inactivation of the Cerebellar Vermis by cTBS.
[So] Source:Cerebellum;16(1):1-14, 2017 Feb.
[Is] ISSN:1473-4230
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Balance stability correlates with cerebellar vermis volume. Furthermore, the cerebellum is involved in precise timing of motor processes by fine-tuning the sensorimotor integration. We tested the hypothesis that any cerebellar action in stance control and in timing of visuomotor integration for balance is impaired by continuous theta-burst stimulation (cTBS) of the vermis. Ten subjects stood quietly and underwent six sequences of 10-min acquisition of center of foot pressure (CoP) data after cTBS, sham stimulation, and no stimulation. Visual shifts from eyes closed (EC) to eyes open (EO) and vice versa were presented via electronic goggles. Mean anteroposterior and mediolateral CoP position and oscillation, and the time delay at which body sway changed after visual shift were calculated. CoP position under both EC and EO condition was not modified after cTBS. Sway path length was greater with EC than EO and increased in both visual conditions after cTBS. CoP oscillation was also larger with EC and increased under both visual conditions after cTBS. The delay at which body oscillation changed after visual shift was longer after EC to EO than EO to EC, but unaffected by cTBS. The time constant of decrease or increase of oscillation was longer in EC to EO shifts, but unaffected by cTBS. Functional inactivation of the cerebellar vermis is associated with increased sway. Despite this, cTBS does not detectably modify onset and time course of the sensorimotor integration process of adaptation to visual shifts. Cerebellar vermis normally controls oscillation, but not timing of adaptation to abrupt changes in stabilizing information.
[Mh] Termos MeSH primário: Vermis Cerebelar/fisiopatologia
Equilíbrio Postural/fisiologia
[Mh] Termos MeSH secundário: Adulto
Análise de Variância
Medições dos Movimentos Oculares
Feminino
Seres Humanos
Masculino
Pressão
Fatores de Tempo
Estimulação Magnética Transcraniana
Percepção Visual
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160119
[St] Status:MEDLINE
[do] DOI:10.1007/s12311-015-0758-5


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[PMID]:27839999
[Au] Autor:Suvrathan A; Payne HL; Raymond JL
[Ad] Endereço:Department of Neurobiology, Stanford University, Stanford, CA 94305, USA. Electronic address: aparnasu@stanford.edu.
[Ti] Título:Timing Rules for Synaptic Plasticity Matched to Behavioral Function.
[So] Source:Neuron;92(5):959-967, 2016 Dec 07.
[Is] ISSN:1097-4199
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:It is widely assumed that the complexity of neural circuits enables them to implement diverse learning tasks using just a few generic forms of synaptic plasticity. In contrast, we report that synaptic plasticity can itself be precisely tuned to the requirements of a learning task. We found that the rules for induction of long-term and single-trial plasticity at parallel fiber-to-Purkinje cell synapses vary across cerebellar regions. In the flocculus, associative plasticity in vitro and in vivo is narrowly tuned for an interval of ∼120 ms, which compensates for the specific processing delay for error signals to reach the flocculus during oculomotor learning. In the vermis, which supports a range of behavioral functions, plasticity is induced by a range of intervals, with individual cells tuned for different intervals. Thus, plasticity at a single, anatomically defined type of synapse can have properties that vary in a way that is precisely matched to function.
[Mh] Termos MeSH primário: Vermis Cerebelar/fisiologia
Movimentos Oculares/fisiologia
Aprendizagem/fisiologia
Depressão Sináptica de Longo Prazo/fisiologia
Plasticidade Neuronal/fisiologia
Células de Purkinje/fisiologia
[Mh] Termos MeSH secundário: Animais
Vermis Cerebelar/citologia
Cerebelo/citologia
Cerebelo/fisiologia
Feedback Formativo
Técnicas In Vitro
Masculino
Camundongos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


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[PMID]:27601251
[Au] Autor:Lam CK; Tokuno CD; Staines WR; Bent LR
[Ad] Endereço:Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada.
[Ti] Título:The direction of the postural response to a vestibular perturbation is mediated by the cerebellar vermis.
[So] Source:Exp Brain Res;234(12):3689-3697, 2016 Dec.
[Is] ISSN:1432-1106
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:When an electrical stimulus is applied to perturb the vestibular system, a postural response is generated orthogonal to head orientation. It has previously been shown that there is a convergence of neck proprioceptive and vestibular input within the cerebellum to provide a head-on-body reference frame (Manzoni et al. in Neuroscience 93:1095-1107, 1999). The objective of this experiment was to determine whether the direction of the postural response to a vestibular perturbation is modulated when function of the cerebellar vermis is temporarily depressed. Twenty participants were randomly assigned to a SHAM group (paired-pulse transcranial magnetic stimulation) or a TEST group (continuous theta burst stimulation). Stochastic vestibular stimulation (SVS) was applied to standing subjects with their head facing forward or over their left shoulder. Cumulant density traces were established between the SVS and shear force over 180°, and the peak amplitude determined the direction of sway. There were no significant changes in sway direction when the head was facing forward for either stimulation (TEST or SHAM; p = 0.889) or when the head was facing over the shoulder for the SHAM condition (p = 0.954). There was, however, a significant change in sway direction when the head was turned with a depressed cerebellum (p = 0.018); from the expected antero-posterior direction, orthogonal to head orientation, to one slightly more mediolateral with respect to the feet. These results suggest the cerebellum plays a role in the integration of input to generate an appropriately directed postural response relative to the head position.
[Mh] Termos MeSH primário: Vermis Cerebelar/fisiologia
Orientação/fisiologia
Postura/fisiologia
Vestíbulo do Labirinto/fisiologia
[Mh] Termos MeSH secundário: Adulto
Fenômenos Biomecânicos
Feminino
Lateralidade Funcional
Movimentos da Cabeça
Seres Humanos
Masculino
Equilíbrio Postural
Processos Estocásticos
Ritmo Teta
Estimulação Magnética Transcraniana
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE


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[PMID]:27565053
[Au] Autor:Nirgudkar P; Taylor DH; Yanagawa Y; Valenzuela CF
[Ad] Endereço:Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, School of Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, U.S.A.
[Ti] Título:Ethanol exposure during development reduces GABAergic/glycinergic neuron numbers and lobule volumes in the mouse cerebellar vermis.
[So] Source:Neurosci Lett;632:86-91, 2016 Oct 06.
[Is] ISSN:1872-7972
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Cerebellar alterations are a hallmark of Fetal Alcohol Spectrum Disorders and are thought to be responsible for deficits in fine motor control, motor learning, balance, and higher cognitive functions. These deficits are, in part, a consequence of dysfunction of cerebellar circuits. Although the effect of developmental ethanol exposure on Purkinje and granule cells has been previously characterized, its actions on other cerebellar neuronal populations are not fully understood. Here, we assessed the impact of repeated ethanol exposure on the number of inhibitory neurons in the cerebellar vermis. We exposed pregnant mice to ethanol in vapor inhalation chambers during gestational days 12-19 and offspring during postnatal days 2-9. We used transgenic mice expressing the fluorescent protein, Venus, in GABAergic/glycinergic neurons. Using unbiased stereology techniques, we detected a reduction in Venus positive neurons in the molecular and granule cell layers of lobule II in the ethanol exposed group at postnatal day 16. In contrast, ethanol produced a more widespread reduction in Purkinje cell numbers that involved lobules II, IV-V and IX. We also found a reduction in the volume of lobules II, IV-V, VI-VII, IX and X in ethanol-exposed pups. These findings indicate that second and third trimester-equivalent ethanol exposure has a greater impact on Purkinje cells than interneurons in the developing cerebellar vermis. The decrease in the volume of most lobules could be a consequence of a reduction in cell numbers, dendritic arborizations, or axonal projections.
[Mh] Termos MeSH primário: Vermis Cerebelar/efeitos dos fármacos
Etanol/farmacologia
Neurônios GABAérgicos/efeitos dos fármacos
Glicina/metabolismo
Neurônios/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Contagem de Células
Vermis Cerebelar/citologia
Vermis Cerebelar/metabolismo
Feminino
Neurônios GABAérgicos/citologia
Neurônios GABAérgicos/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Neurônios/citologia
Neurônios/metabolismo
Gravidez
Efeitos Tardios da Exposição Pré-Natal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
3K9958V90M (Ethanol); TE7660XO1C (Glycine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160828
[St] Status:MEDLINE


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[PMID]:27555144
[Au] Autor:Jacob J; Alexander A; Philip S; Thomas A
[Ad] Endereço:Department of Anesthesiology, Lourdes Hospital, Ernakulam, Kochi, Kerala 682012, India. Electronic address: jeanjacob82@gmail.com.
[Ti] Título:Prone position craniotomy in pregnancy without fetal heart rate monitoring.
[So] Source:J Clin Anesth;33:119-22, 2016 Sep.
[Is] ISSN:1873-4529
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A pregnant patient in second trimester scheduled for posterior fossa craniotomy in prone position is a challenge for the anesthesiologist. Things to consider are physiological changes during pregnancy, non-obstetric surgery in pregnant patients, neuroanesthetic principles, effects of prone positioning, and need for fetal heart rate (FHR) monitoring. We have described the anesthetic management of this case and discussed intra-operative FHR monitoring including controversies about its role, indications, and various options available as per fetal gestational age. In our case we attempted intermittent intra-operative FHR monitoring to optimize maternal positioning and fetal oxygenation even though the fetus was pre-viable. However the attempt was abandoned due to practical difficulties with prone positioning. Patient made good neurological recovery following the procedure and delivered a healthy term baby 4 months later. Decisions regarding fetal monitoring should be individualized based on viability of the fetus and feasibility of emergency cesarean delivery. Good communication between a multidisciplinary team involving neurosurgeon, anesthesiologist, obstetrician, and neonatologist is important for a successful outcome for mother and fetus. We conclude that prone position neurosurgery can safely be carried out in a pregnant patient with pre-viable fetus without FHR monitoring.
[Mh] Termos MeSH primário: Encefalopatias/cirurgia
Craniotomia/métodos
Cisto Epidérmico/cirurgia
Monitorização Fetal
Complicações na Gravidez/cirurgia
[Mh] Termos MeSH secundário: Adulto
Encefalopatias/diagnóstico por imagem
Vermis Cerebelar/diagnóstico por imagem
Contraindicações
Cisto Epidérmico/diagnóstico por imagem
Feminino
Frequência Cardíaca Fetal
Seres Humanos
Recém-Nascido
Imagem por Ressonância Magnética
Posicionamento do Paciente/métodos
Gravidez
Complicações na Gravidez/diagnóstico por imagem
Resultado da Gravidez
Decúbito Ventral
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160825
[St] Status:MEDLINE



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