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[PMID]:29068990
[Au] Autor:Jang SH; Kwon HG
[Ad] Endereço:aDepartment of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Daegu bDepartment of Physical Therapy, College of Health Sciences, Catholic University of Pusan, Republic of Korea.
[Ti] Título:Aggravation of an injured dentato-rubro-thalamic tract in a patient with mild traumatic brain injury: A case report.
[So] Source:Medicine (Baltimore);96(43):e8253, 2017 Oct.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a patient with mild traumatic brain injury (TBI) by follow-up diffusion tensor tractography (DTT), and observed for approximately nine monthsby serial diffusion tensor tractography (DTT). PATIENT CONCERNS: A 66-year-old male patient was injured in a car crash. Approximately four weeks after the crash, he developed a tremor in the right hand and leg. His symptoms worsened over time. DIAGNOSES: Approximately six months after the crash, he developed a mild tremor in the left hand. Nine months after the crash, he manifested severe tremor in his right hand, mild resting and intentional tremor in his left hand and both legs, and mild trunkal ataxia. INTERVENTIONS: N/A. OUTCOMES: On 3-week DTT, well reconstructed DRTTs were observed in both hemispheres, except for the thinned lower portion of the right DRTT. On 9-month DTT, the right lower DRTT had thinned compared with the 3-week DTT and showed a disruption at the upper portion. The left DRTT showed thinning in the lower portion and tearing in the upper portion compared with 3-week DTT. LESSONS: Aggravation of an injured DRTT was demonstrated in a patient with mild TBI, using serial DTT examination.
[Mh] Termos MeSH primário: Concussão Encefálica/complicações
Núcleos Cerebelares/lesões
Tálamo/lesões
[Mh] Termos MeSH secundário: Acidentes de Trânsito
Idoso
Ataxia/etiologia
Concussão Encefálica/diagnóstico por imagem
Núcleos Cerebelares/diagnóstico por imagem
Imagem de Tensor de Difusão
Vias Eferentes/diagnóstico por imagem
Vias Eferentes/lesões
Seguimentos
Mãos/fisiopatologia
Seres Humanos
Perna (Membro)/fisiopatologia
Masculino
Tálamo/diagnóstico por imagem
Tremor/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171123
[Lr] Data última revisão:
171123
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171026
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008253


  2 / 2715 MEDLINE  
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[PMID]:29044415
[Au] Autor:Hopley RT; Haller E; Rojiani MV; Rojiani AM
[Ad] Endereço:Department of Pathology, School of Medicine, University of South Florida-Morsani, Tampa, Florida; Medical College of Georgia, Augusta University, Augusta, Georgia.
[Ti] Título:Morphologic and Elemental Analysis of Primary Melanosis of the Dentate Nucleus: Review and Correlation With Neuromelanin.
[So] Source:J Neuropathol Exp Neurol;76(11):949-956, 2017 Nov 01.
[Is] ISSN:1554-6578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Primary melanosis of the dentate nucleus is a rarely described entity with neither known cause nor definitive clinicopathologic correlation. We revisit this previously reported phenomenon by presenting one such case with a review of the pathology as well as additional investigations including elemental analysis by energy-dispersive X-ray, immunohistochemistry and electron microscopy. The lesion presented macroscopically as a sharply defined, black pigmentation that was restricted to the dentate nucleus of the cerebellum. Other deep nuclei were uninvolved. Similarly, other areas of the cerebellum, brainstem, and supratentorial regions were macroscopically free of pigment. Microscopically, however, the pigment was noted to be present, albeit in microscopic deposits, within layers of the cerebellar cortex. Additionally, immunohistochemistry and electron microscopy defined an intracellular component within astrocytes. X-ray analysis of the pigment showed it to consist almost entirely of sulfur, an element known to be prominent in neuromelanin. This report also describes an association of the pigment with astrocytes by ultrastructural examination. We discuss the results of our findings in the context of etiopathogenetic considerations, seeking to gain a better understanding of this abnormal pigmentation and its relationship to neuromelanin.
[Mh] Termos MeSH primário: Núcleos Cerebelares/metabolismo
Núcleos Cerebelares/patologia
Melaninas/metabolismo
Melanose/metabolismo
Melanose/patologia
[Mh] Termos MeSH secundário: Núcleos Cerebelares/ultraestrutura
Evolução Fatal
Seres Humanos
Masculino
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Melanins); 0 (neuromelanin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171019
[St] Status:MEDLINE
[do] DOI:10.1093/jnen/nlx084


  3 / 2715 MEDLINE  
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[PMID]:28916520
[Au] Autor:Beitzel CS; Houck BD; Lewis SM; Person AL
[Ad] Endereço:Neuroscience Graduate Program, and.
[Ti] Título:Rubrocerebellar Feedback Loop Isolates the Interposed Nucleus as an Independent Processor of Corollary Discharge Information in Mice.
[So] Source:J Neurosci;37(42):10085-10096, 2017 Oct 18.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding cerebellar contributions to motor coordination requires deeper insight into how the output structures of the cerebellum, the cerebellar nuclei, integrate their inputs and influence downstream motor pathways. The magnocellular red nucleus (RNm), a brainstem premotor structure, is a major target of the interposed nucleus (IN), and has also been described in previous studies to send feedback collaterals to the cerebellum. Because such a pathway is in a key position to provide motor efferent information to the cerebellum, satisfying predictions about the use of corollary discharge in cerebellar computations, we studied it in mice of both sexes. Using anterograde viral tracing, we show that innervation of cerebellum by rubrospinal neuron collaterals is remarkably selective for the IN compared with the cerebellar cortex. Optogenetic activation of the pathway in acute mouse brain slices drove IN activity despite small amplitude synaptic currents, suggesting an active role in IN information processing. Monosynaptic transsynaptic rabies tracing indicated the pathway contacts multiple cell types within the IN. By contrast, IN inputs to the RNm targeted a region that lacked inhibitory neurons. Optogenetic drive of IN inputs to the RNm revealed strong, direct excitation but no inhibition of RNm neurons. Together, these data indicate that the cerebellar nuclei are under afferent control independent of the cerebellar cortex, potentially diversifying its roles in motor control. The common assumption that all cerebellar mossy fibers uniformly collateralize to the cerebellar nuclei and cortex underlies classic models of convergent Purkinje influence on cerebellar output. Specifically, mossy fibers are thought to both directly excite nuclear neurons and drive polysynaptic feedforward inhibition via Purkinje neurons, setting up a fundamental computational unit. Here we present data that challenge this rule. A dedicated cerebellar nuclear afferent comprised of feedback collaterals from premotor rubrospinal neurons can directly modulate IN output independent of Purkinje cell modulation. In contrast to the IN-RNm pathway, the RNm-IN feedback pathway targets multiple cell types, potentially influencing both motor output pathways and nucleo-olivary feedback.
[Mh] Termos MeSH primário: Núcleos Cerebelares/fisiologia
Retroalimentação Fisiológica/fisiologia
Inibição Neural/fisiologia
Núcleo Rubro/fisiologia
[Mh] Termos MeSH secundário: Animais
Potenciais Pós-Sinápticos Excitadores/fisiologia
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Camundongos Transgênicos
Vias Neurais/fisiologia
Técnicas de Cultura de Órgãos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170917
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.1093-17.2017


  4 / 2715 MEDLINE  
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[PMID]:28885891
[Au] Autor:Bjørnerud A; Vatnehol SAS; Larsson C; Due-Tønnessen P; Hol PK; Groote IR
[Ad] Endereço:From the Department of Diagnostic Physics (A.B., C.L., I.R.G.), Intervention Centre (S.A.S.V., P.K.H.), and Department of Radiology (P.D.T.), Oslo University Hospital, Rikshospitalet, Sognsvannsveien 20, N-0372 Oslo, Norway; Faculty of Mathematics and Natural Sciences, Institute of Physics (A.B) and
[Ti] Título:Signal Enhancement of the Dentate Nucleus at Unenhanced MR Imaging after Very High Cumulative Doses of the Macrocyclic Gadolinium-based Contrast Agent Gadobutrol: An Observational Study.
[So] Source:Radiology;285(2):434-444, 2017 Nov.
[Is] ISSN:1527-1315
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Purpose To test for measurable visual enhancement of the dentate nucleus (DN) on unenhanced T1-weighted magnetic resonance (MR) images in a cohort of patients with a primary brain tumor who had not received linear gadolinium-based contrast agents (GBCAs) but had received many injections of macrocyclic GBCAs. Materials and Methods Seventeen patients with high-grade gliomas who had received 10-44 administrations of the macrocyclic GBCA gadobutrol (0.1 mmol/kg of body weight) were retrospectively included in this regional ethics committee-approved study. Two neuroradiologists inspected T1-weighted MR images with optimized window settings to visualize small differences in contrast at the baseline and at the last examination for the presence of visual DN signal enhancement. Signal intensity (SI) in the DN was normalized to the SI of the pons, and a one-sample t test was used to test for differences between baseline normalized SI (nSI) in the DN (nSI ) and the average change in nSI of all postbaseline MR imaging sessions (ΔnSI ) or the change in nSI from baseline to the last MR imaging session (ΔnSI ). Linear and quadratic correlation analyses were used to examine the association between the number of macrocyclic GBCA administrations and ΔnSI or ΔnSI . Results The mean ± standard deviation number of macrocyclic GBCA administrations was 22.2 ± 10.6 administered throughout 706 days ± 454. Visually appreciable signal enhancement was observed in two patients who had received 37 and 44 macrocyclic GBCA injections. Mean ΔnSI was greater than zero (0.03 ± 0.05; P = .016), and there was a significant linear association between the number of macrocyclic GBCA injections and ΔnSI (r = 0.69, P = .002) and ΔnSI (r = 0.77, P < .001). Conclusion A small but statistically significant dose-dependent T1-weighted signal enhancement was observed in the DN after multiple macrocyclic GBCA injections. Visually appreciable enhancement in the DN was observed on contrast-optimized images in two patients who had received 37 and 44 standard doses of macrocyclic GBCAs. RSNA, 2017 Online supplemental material is available for this article.
[Mh] Termos MeSH primário: Núcleos Cerebelares/diagnóstico por imagem
Meios de Contraste/administração & dosagem
Imagem por Ressonância Magnética/métodos
Compostos Organometálicos/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Idoso
Meios de Contraste/uso terapêutico
Feminino
Seres Humanos
Masculino
Meia-Idade
Compostos Organometálicos/uso terapêutico
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Contrast Media); 0 (Organometallic Compounds); 1BJ477IO2L (gadobutrol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171030
[Lr] Data última revisão:
171030
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.1148/radiol.2017170391


  5 / 2715 MEDLINE  
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[PMID]:28859167
[Au] Autor:Lee JY; Park JE; Kim HS; Kim SO; Oh JY; Shim WH; Jung SC; Choi CG; Kim SJ
[Ad] Endereço:Department of Radiology, Soonchunhyang University Bucheon Hospital, Wonmi-gu, Bucheon, Korea.
[Ti] Título:Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients.
[So] Source:PLoS One;12(8):e0183916, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, 385 consecutive patients who underwent MICA-enhanced MR imaging were enrolled. The dentate nucleus-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) signal intensity (SI) ratios on unenhanced T1-weighted images were recorded by 2 independent readers and averaged. The mean DN/P and GP/Th SI ratio difference between the last and the first examinations were tested using the one-sample t-test. Student's t-test and stepwise regression analysis were used to identify the predisposing factors for deposition based on the number of administrations, time interval, hepatic and renal function, magnetic field strength, and chemo- or radiation therapy. RESULTS: The mean DN/P SI ratio difference was not different from zero (P = .697), even in patients with ≥20 administrations (n = 33). Only patients with abnormal renal function showed an increase in the mean DN/P SI ratio difference (P = .019). The mean DN/P SI ratio difference was not associated with any predisposing factors. However, the mean GP/Th SI ratio difference showed decrease (P < .001), which was associated with age (P = .007), number of administrations (P = .01) and number of radiation therapy sessions (P = .022) on multivariate analysis. CONCLUSION: Multiple repeated administrations of MICA were not associated with increased T1 signal intensity in deep brain nuclei suggestive of Gd deposition in patients with normal renal function.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Núcleos Cerebelares/diagnóstico por imagem
Meios de Contraste/farmacocinética
Gadolínio/farmacocinética
Globo Pálido/diagnóstico por imagem
Ponte/diagnóstico por imagem
Tálamo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Núcleos Cerebelares/metabolismo
Núcleos Cerebelares/patologia
Esquema de Medicação
Feminino
Globo Pálido/metabolismo
Globo Pálido/patologia
Seres Humanos
Testes de Função Renal
Testes de Função Hepática
Imagem por Ressonância Magnética
Meia-Idade
Ponte/metabolismo
Ponte/patologia
Estudos Retrospectivos
Tálamo/metabolismo
Tálamo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183916


  6 / 2715 MEDLINE  
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[PMID]:28672395
[Au] Autor:Gaura V; Lavisse S; Payoux P; Goldman S; Verny C; Krystkowiak P; Damier P; Supiot F; Bachoud-Levi AC; Remy P
[Ad] Endereço:Commissariat à l'Energie Atomique et aux Energies Alternatives, Département des Sciences du Vivant, Institut d'Imagerie Biomédicale, MIRCen, Fontenay-aux-Roses, France.
[Ti] Título:Association Between Motor Symptoms and Brain Metabolism in Early Huntington Disease.
[So] Source:JAMA Neurol;74(9):1088-1096, 2017 Sep 01.
[Is] ISSN:2168-6157
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Brain hypometabolism is associated with the clinical consequences of the degenerative process, but little is known about regional hypermetabolism, sometimes observed in the brain of patients with clinically manifest Huntington disease (HD). Studying the role of regional hypermetabolism is needed to better understand its interaction with the motor symptoms of the disease. Objective: To investigate the association between brain hypometabolism and hypermetabolism with motor scores of patients with early HD. Design, Setting, and Participants: This study started in 2001, and analysis was completed in 2016. Sixty symptomatic patients with HD and 15 healthy age-matched control individuals underwent positron emission tomography to measure cerebral metabolism in this cross-sectional study. They also underwent the Unified Huntington's Disease Rating Scale motor test, and 2 subscores were extracted: (1) a hyperkinetic score, combining dystonia and chorea, and (2) a hypokinetic score, combining bradykinesia and rigidity. Main Outcomes and Measures: Statistical parametric mapping software (SPM5) was used to identify all hypo- and hypermetabolic regions in patients with HD relative to control individuals. Correlation analyses (P < .001, uncorrected) between motor subscores and brain metabolic values were performed for regions with significant hypometabolism and hypermetabolism. Results: Among 60 patients with HD, 22 were women (36.7%), and the mean (SD) age was 44.6 (7.6) years. Of the 15 control individuals, 7 were women (46.7%), and the mean (SD) age was 42.2 (7.3) years. In statistical parametric mapping, striatal hypometabolism was significantly correlated with the severity of all motor scores. Hypermetabolism was negatively correlated only with hypokinetic scores in the cuneus (z score = 3.95, P < .001), the lingual gyrus (z score = 4.31, P < .001), and the crus I/II of the cerebellum (z score = 3.77, P < .001), a region connected to associative cortical areas. More severe motor scores were associated with higher metabolic values in the inferior parietal lobule, anterior cingulate, inferior temporal lobule, the dentate nucleus, and the cerebellar lobules IV/V, VI, and VIII bilaterally corresponding to the motor regions of the cerebellum (z score = 3.96 and 3.42 in right and left sides, respectively; P < .001). Conclusions and Relevance: Striatal hypometabolism is associated with clinical disease severity. Conversely, hypermetabolism is likely compensatory in regions where it is associated with decreasing motor scores. Hypermetabolism might be detrimental in other structures in which it is associated with more severe motor symptoms. In the cerebellum, both compensatory and detrimental contributions seem to occur. This study helps to better understand the motor clinical relevance of hypermetabolic brain regions in HD.
[Mh] Termos MeSH primário: Cerebelo/metabolismo
Córtex Cerebral/metabolismo
Doença de Huntington/metabolismo
Hipercinese/metabolismo
Hipocinesia/metabolismo
[Mh] Termos MeSH secundário: Adulto
Núcleos Cerebelares/diagnóstico por imagem
Núcleos Cerebelares/metabolismo
Cerebelo/diagnóstico por imagem
Córtex Cerebral/diagnóstico por imagem
Estudos Transversais
Feminino
Seres Humanos
Doença de Huntington/complicações
Doença de Huntington/diagnóstico por imagem
Hipercinese/diagnóstico por imagem
Hipercinese/etiologia
Hipocinesia/diagnóstico por imagem
Hipocinesia/etiologia
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.1001/jamaneurol.2017.1200


  7 / 2715 MEDLINE  
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[PMID]:28640114
[Au] Autor:Jang SH; Kwon HG
[Ad] Endereço:aCollege of Medicine, Department of Physical Medicine and Rehabilitation, Yeungnam University, Daegu bDepartment of Physical Therapy, College of Health Sciences, Catholic University of Pusan, Republic of Korea.
[Ti] Título:Injury of the dentato-rubro-thalamic tract in patients with cerebellar infarct: Case report.
[So] Source:Medicine (Baltimore);96(25):e7220, 2017 Jun.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: Several studies using diffusion tensor tractography (DTT) have reported on injury in the dentato-rubro-thalamic tract (DRTT) in patients with brain injury. However, there is no study of injury in the DRTT following cerebellar infarct. We report on patients with injury in the DRTT following cerebellar infarct, demonstrated on DTT. PATIENT CONCERNS: Three patients with cerebellar infarct were enrolled in this study. Diffusion tensor imaging data were acquired at 3 weeks (patient 1) and 2 weeks (patients 2 and 3) after onset and the DRTT was reconstructed. The Scale for Assessment and Rating of Ataxiaand the Functional Ambulation Category were used for evaluation of ataxia and gait function. DIAGNOSES AND OUTCOMES: With clinical evaluation, patient 1 scored 18, patient 2 scored 22, and patient 3 scored 28 points on the Scale for Assessment and Rating of Ataxia. On the Functional Ambulation Category patient 1 scored 2, patient 2 scored 2, and patient 3 scored 1 point. DRTT abnormalities were as follows: discontinuation (the upper portion of the left DRTT in the patient 1), narrowing (the lower portion of the left DRTT in patient 2, and the whole right DRTT in the patient 3), and nonreconstruction (the left DRTT in the patient 3). LESSONS: Using DTT, we demonstrated injury in the DRTT in 3 patients with severe ataxia following cerebellar infarct. We believe that evaluation of the DRTT would be helpful in patients who develop ataxia following cerebellar infarct.
[Mh] Termos MeSH primário: Infarto Encefálico/diagnóstico por imagem
Núcleos Cerebelares/diagnóstico por imagem
Tálamo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Ataxia/diagnóstico por imagem
Ataxia/etiologia
Infarto Encefálico/complicações
Imagem de Difusão por Ressonância Magnética
Imagem de Tensor de Difusão
Feminino
Seres Humanos
Masculino
Meia-Idade
Vias Neurais/diagnóstico por imagem
Índice de Gravidade de Doença
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170717
[Lr] Data última revisão:
170717
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000007220


  8 / 2715 MEDLINE  
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[PMID]:28617798
[Au] Autor:Abbasi S; Hudson AE; Maran SK; Cao Y; Abbasi A; Heck DH; Jaeger D
[Ad] Endereço:Department of Biology, Emory University, Atlanta, GA, United States of America.
[Ti] Título:Robust transmission of rate coding in the inhibitory Purkinje cell to cerebellar nuclei pathway in awake mice.
[So] Source:PLoS Comput Biol;13(6):e1005578, 2017 Jun.
[Is] ISSN:1553-7358
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Neural coding through inhibitory projection pathways remains poorly understood. We analyze the transmission properties of the Purkinje cell (PC) to cerebellar nucleus (CN) pathway in a modeling study using a data set recorded in awake mice containing respiratory rate modulation. We find that inhibitory transmission from tonically active PCs can transmit a behavioral rate code with high fidelity. We parameterized the required population code in PC activity and determined that 20% of PC inputs to a full compartmental CN neuron model need to be rate-comodulated for transmission of a rate code. Rate covariance in PC inputs also accounts for the high coefficient of variation in CN spike trains, while the balance between excitation and inhibition determines spike rate and local spike train variability. Overall, our modeling study can fully account for observed spike train properties of cerebellar output in awake mice, and strongly supports rate coding in the cerebellum.
[Mh] Termos MeSH primário: Potenciais de Ação/fisiologia
Núcleos Cerebelares/fisiologia
Modelos Neurológicos
Rede Nervosa/fisiologia
Inibição Neural/fisiologia
Células de Purkinje/fisiologia
[Mh] Termos MeSH secundário: Animais
Simulação por Computador
Feminino
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Vias Neurais/fisiologia
Vigília/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170909
[Lr] Data última revisão:
170909
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pcbi.1005578


  9 / 2715 MEDLINE  
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[PMID]:28362042
[Au] Autor:Malikova H; Holesta M
[Ad] Endereço:Department of Radiology, Faculty Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, Prague - Czech Republic.
[Ti] Título:Gadolinium contrast agents - are they really safe?
[So] Source:J Vasc Access;18(Suppl. 2):1-7, 2017 Mar 28.
[Is] ISSN:1724-6032
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Gadolinium-based contrast agents (GBCA) are used worldwide for enhanced MRI examinations, including heart and vessels. Gadolinium is a highly toxic heavy metal. If used in GBCA it must be tightly bound to ligands. The configuration of ligands influences the stability of the GBCA and two types of chelates have been used. Macrocyclic chelates offer better protection and binding of gadolinium ion than linear chelates with a flexible open chain - gadolinium could be more easily released from the latter ones. GBCAs are excreted from the body mostly by the kidneys, which is of importance in chronic kidney disease.Two states are related to gadolinium: nephrogenic systemic fibrosis (NSF) and gadolinium body storage. NSF is a severe and debilitating disease, directly connected to gadolinium toxicity, proven after the use of linear chelates. Due to strict recommendations of radiology societies, NSF was practically eradicated. Gadolinium deposition was observed especially in bones and in some brain areas: in dentate nucleus and in globus pallidus, even years after the GBCA administration. The form of the storage (chelated or free), as well as their clinical impact, are not clear, but first observations of "gadolinium deposition disease" have been reported.
[Mh] Termos MeSH primário: Meios de Contraste/efeitos adversos
Gadolínio/efeitos adversos
Imagem por Ressonância Magnética/efeitos adversos
Dermopatia Fibrosante Nefrogênica/induzido quimicamente
Compostos Organometálicos/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Carga Corporal (Radioterapia)
Osso e Ossos/metabolismo
Núcleos Cerebelares/metabolismo
Meios de Contraste/metabolismo
Gadolínio/metabolismo
Globo Pálido/metabolismo
Seres Humanos
Dermopatia Fibrosante Nefrogênica/diagnóstico
Compostos Organometálicos/metabolismo
Segurança do Paciente
Valor Preditivo dos Testes
Medição de Risco
Fatores de Risco
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Contrast Media); 0 (Organometallic Compounds); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.5301/jva.5000713


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[PMID]:28320027
[Au] Autor:Anthofer JM; Steib K; Lange M; Rothenfusser E; Fellner C; Brawanski A; Schlaier J
[Ad] Endereço:Department of Neurosurgery, Universitatsklinikum Regensburg Klinik und Poliklinik fur Neurochirurgie Ringgold Standard Institution, Regensburg, Germany.
[Ti] Título:Distance between Active Electrode Contacts and Dentatorubrothalamic Tract in Patients with Habituation of Stimulation Effect of Deep Brain Stimulation in Essential Tremor.
[So] Source:J Neurol Surg A Cent Eur Neurosurg;78(4):350-357, 2017 Jul.
[Is] ISSN:2193-6323
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Some patients under thalamic deep brain stimulation (DBS) for essential tremor (ET) experience habituation of tremor reduction. The nucleus ventralis intermedius (Vim) is the current main target side for ET in DBS. However, the dentatorubrothalamic tract (DRTT) is considered the relevant structure to stimulate. We investigated the distance between the active contact of the DBS electrode and the DRTT and compared this distance in patients with habituation of tremor reduction and good responders. In this retrospective study, we performed deterministic fiber tracking of the DRTT in 6 patients (12 hemispheres) with ET who underwent DBS in the Vim. We subsequently measured the distance between the active contact of the electrode and the ipsilateral DRTT in both hemispheres. The clinical tremor response of those 6 patients was analyzed accordingly. The distance between the active contact and the DRTT in patients with better and constant clinical tremor reduction was shorter (mean distance: 2.9 ± 2.2 mm standard deviation [SD]) than in patients who showed habituation of their response (mean distance: 6.1 ± 3.9 mm SD). After re-placement of a thalamic electrode inside the DRTT in one patient who experienced unsatisfying tremor reduction due to habituation of stimulation, the tremor alleviation was significant and persistent at a 13-month follow-up. This retrospective analysis suggests that recurrence of ET tremor under chronic DBS might be associated with a larger distance between the DRTT and the active lead contact, in comparison with the smaller distances in patients with persistently good tremor control.
[Mh] Termos MeSH primário: Núcleos Cerebelares/cirurgia
Estimulação Encefálica Profunda
Tremor Essencial/cirurgia
Núcleo Rubro/cirurgia
Núcleos Talâmicos/cirurgia
[Mh] Termos MeSH secundário: Idoso
Eletrodos Implantados
Feminino
Seres Humanos
Masculino
Meia-Idade
Recidiva
Estudos Retrospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171013
[Lr] Data última revisão:
171013
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE
[do] DOI:10.1055/s-0036-1597894



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