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[PMID]:29187688
[Au] Autor:Abe S; Okazaki S; Tonomura S; Miyashita K; Ihara M
[Ad] Endereço:Department of Neurology, National Cerebral and Cardiovascular Center, Osaka.
[Ti] Título:[Progressive dysarthria and bilateral sensory disturbance in a case of bilateral ventrolateral pontine infarction].
[So] Source:Rinsho Shinkeigaku;57(12):764-768, 2017 Dec 27.
[Is] ISSN:1882-0654
[Cp] País de publicação:Japan
[La] Idioma:jpn
[Ab] Resumo:A rare case of bilateral ventrolateral pontine infarction in a 70-year-old man who developed progressive dysarthria and bilateral sensory disturbance is reported with literature review. He had been diagnosed with hypertension, dyslipidemia, and impaired glucose tolerance 10 years earlier. Ten days before admission, he was aware of the difficulty in walking and speaking, which gradually worsened. On admission he showed bilateral thermal hypoalgesia of face and lower extremities, dysarthria, dysphagia, and ataxic gait. High resolution three-dimensional MRI revealed bilateral ventrolateral pontine infarction with a large atherosclerotic plaque in the ventral side of the basilar artery, which led to a diagnosis of atherothrombotic brain infarction. The atherosclerotic plaque in the basilar artery was thought to be responsible for simultaneous occlusion of the bilateral short circumflex arteries of the pons.
[Mh] Termos MeSH primário: Infarto Cerebral/etiologia
Disartria/etiologia
Ponte/irrigação sanguínea
Transtornos das Sensações/etiologia
[Mh] Termos MeSH secundário: Idoso
Artéria Basilar/diagnóstico por imagem
Infarto Cerebral/diagnóstico por imagem
Progressão da Doença
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Placa Aterosclerótica/complicações
Placa Aterosclerótica/diagnóstico por imagem
Ponte/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171201
[St] Status:MEDLINE
[do] DOI:10.5692/clinicalneurol.cn-001090


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[PMID]:29245230
[Au] Autor:Jang SH; Kwon HG
[Ad] Endereço:aDepartment of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Gyeongsangbuk-dobDepartment of Physical Therapy, College of Health Sciences, Catholic University of Pusan, Pusan, Republic of Korea.
[Ti] Título:Injury of the cortico-ponto-cerebellar tract in a patient with mild traumatic brain injury: A case report.
[So] Source:Medicine (Baltimore);96(49):e8749, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:RATIONALE: We report on a patient with injury of the cortico-ponto-cerebellar tract (CPCT) following mild traumatic brain injury (TBI), diagnosed by diffusion tensor tractography (DTT). PATIENT CONCERNS: A 53-year-old female patient was injured in a car crash. While under treatment at a local medical center for headache, mild motor weakness, and cognitive impairment that developed following the car crash, she fell, hitting her head on the ground, about six weeks after the car crash. DIAGNOSES: Approximately three months after the car crash, she began to show tremor on both hands and mild truncal ataxia. Twenty months after the car crash, when she underwent neurological evaluation at the rehabilitation department of a university hospital, she presented with mild resting and intentional tremor on both hands, and mild truncal ataxia. INTERVENTIONS: N/A. OUTCOMES: On 20-month DTT, the left CPCT showed tearing at the level of the subcortical white matter and pons, and discontinuation at the cerebellar portion. However, the integrity of the DRTT was well-preserved in both hemispheres. LESSONS: Using DTT, injury of the CPCT was demonstrated in a patient with ataxia and tremor following mild TBI.
[Mh] Termos MeSH primário: Ataxia/etiologia
Lesões Encefálicas Traumáticas/complicações
Cerebelo/lesões
Ponte/lesões
Substância Branca/lesões
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1712
[Cu] Atualização por classe:171222
[Lr] Data última revisão:
171222
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:171217
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008749


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[PMID]:28885086
[Au] Autor:Kamei T; Nonaka M; Uemura Y; Yamanouchi Y; Komori Y; Iwata R; Takeda J; Hashiba T; Yoshimura K; Asai A
[Ad] Endereço:Departments of 1 Neurosurgery and.
[Ti] Título:Enlarging pediatric ectopic Rathke's cleft cyst in the prepontine cistern: case report.
[So] Source:J Neurosurg Pediatr;20(5):480-484, 2017 Nov.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rathke's cleft cyst is a cystic disease that occurs in the sella turcica or, occasionally, in the suprasellar area. An ectopic Rathke's cleft cyst is extremely rare, and its nature is less well understood. The authors report the case of a 14-year-old girl who presented with a growing cystic lesion in the prepontine cistern, immediately behind the dorsum sellae. Preoperative imaging and intraoperative investigation showed part of the cyst wall continuing into the dorsum sellae, to the pituitary gland. The cisternal portion of the cyst wall was totally resected via a right subtemporal approach. Histopathological examination of the cyst wall showed a monolayer of ciliated cells, identical to those of Rathke's cleft cyst. To the best of the authors' knowledge, this represents the first pediatric case of Rathke's cleft cyst occurring in the prepontine cistern.
[Mh] Termos MeSH primário: Cistos do Sistema Nervoso Central/diagnóstico por imagem
Cistos do Sistema Nervoso Central/cirurgia
Hipófise/diagnóstico por imagem
Hipófise/cirurgia
Espaço Subaracnóideo
[Mh] Termos MeSH secundário: Adolescente
Cistos do Sistema Nervoso Central/patologia
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Hipófise/patologia
Ponte
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170909
[St] Status:MEDLINE
[do] DOI:10.3171/2017.6.PEDS1727


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[PMID]:28859167
[Au] Autor:Lee JY; Park JE; Kim HS; Kim SO; Oh JY; Shim WH; Jung SC; Choi CG; Kim SJ
[Ad] Endereço:Department of Radiology, Soonchunhyang University Bucheon Hospital, Wonmi-gu, Bucheon, Korea.
[Ti] Título:Up to 52 administrations of macrocyclic ionic MR contrast agent are not associated with intracranial gadolinium deposition: Multifactorial analysis in 385 patients.
[So] Source:PLoS One;12(8):e0183916, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To determine whether multiple repeated administrations of gadolinium-based macrocyclic ionic MR contrast agent (MICA) are associated with intracranial gadolinium deposition and identify the predisposing factors for deposition in various clinical situations. MATERIALS AND METHODS: In this institutional review board-approved retrospective study, 385 consecutive patients who underwent MICA-enhanced MR imaging were enrolled. The dentate nucleus-to-pons (DN/P) and globus pallidus-to-thalamus (GP/Th) signal intensity (SI) ratios on unenhanced T1-weighted images were recorded by 2 independent readers and averaged. The mean DN/P and GP/Th SI ratio difference between the last and the first examinations were tested using the one-sample t-test. Student's t-test and stepwise regression analysis were used to identify the predisposing factors for deposition based on the number of administrations, time interval, hepatic and renal function, magnetic field strength, and chemo- or radiation therapy. RESULTS: The mean DN/P SI ratio difference was not different from zero (P = .697), even in patients with ≥20 administrations (n = 33). Only patients with abnormal renal function showed an increase in the mean DN/P SI ratio difference (P = .019). The mean DN/P SI ratio difference was not associated with any predisposing factors. However, the mean GP/Th SI ratio difference showed decrease (P < .001), which was associated with age (P = .007), number of administrations (P = .01) and number of radiation therapy sessions (P = .022) on multivariate analysis. CONCLUSION: Multiple repeated administrations of MICA were not associated with increased T1 signal intensity in deep brain nuclei suggestive of Gd deposition in patients with normal renal function.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/diagnóstico por imagem
Núcleos Cerebelares/diagnóstico por imagem
Meios de Contraste/farmacocinética
Gadolínio/farmacocinética
Globo Pálido/diagnóstico por imagem
Ponte/diagnóstico por imagem
Tálamo/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Núcleos Cerebelares/metabolismo
Núcleos Cerebelares/patologia
Esquema de Medicação
Feminino
Globo Pálido/metabolismo
Globo Pálido/patologia
Seres Humanos
Testes de Função Renal
Testes de Função Hepática
Imagem por Ressonância Magnética
Meia-Idade
Ponte/metabolismo
Ponte/patologia
Estudos Retrospectivos
Tálamo/metabolismo
Tálamo/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Contrast Media); AU0V1LM3JT (Gadolinium)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0183916


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[PMID]:28821646
[Au] Autor:Minert A; Yatziv SL; Devor M
[Ad] Endereço:Department of Cell and Developmental Biology, Institute of Life Sciences, and Center for Research on Pain, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
[Ti] Título:Location of the Mesopontine Neurons Responsible for Maintenance of Anesthetic Loss of Consciousness.
[So] Source:J Neurosci;37(38):9320-9331, 2017 Sep 20.
[Is] ISSN:1529-2401
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The transition from wakefulness to general anesthesia is widely attributed to suppressive actions of anesthetic molecules distributed by the systemic circulation to the cerebral cortex (for amnesia and loss of consciousness) and to the spinal cord (for atonia and antinociception). An alternative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic nuclei, with suppression of cortex and spinal cord mediated by dedicated axonal pathways. Previously, we documented induction of an anesthesia-like state in rats by microinjection of small amounts of GABA -receptor agonists into an upper brainstem region named the mesopontine tegmental anesthesia area (MPTA). Correspondingly, lesioning this area rendered animals resistant to systemically delivered anesthetics. Here, using rats of both sexes, we applied a modified microinjection method that permitted localization of the anesthetic-sensitive neurons with much improved spatial resolution. Microinjected at the MPTA hotspot identified, exposure of 1900 or fewer neurons to muscimol was sufficient to sustain whole-body general anesthesia; microinjection as little as 0.5 mm off-target did not. The GABAergic anesthetics pentobarbital and propofol were also effective. The GABA-sensitive cell cluster is centered on a tegmental (reticular) field traversed by fibers of the superior cerebellar peduncle. It has no specific nuclear designation and has not previously been implicated in brain-state transitions. General anesthesia permits pain-free surgery. Furthermore, because anesthetic agents have the unique ability to reversibly switch the brain from wakefulness to a state of unconsciousness, knowing how and where they work is a potential route to unraveling the neural mechanisms that underlie awareness itself. Using a novel method, we have located a small, and apparently one of a kind, cluster of neurons in the mesopontine tegmentum that are capable of effecting brain-state switching when exposed to GABA -receptor agonists. This action appears to be mediated by a network of dedicated axonal pathways that project directly and/or indirectly to nearby arousal nuclei of the brainstem and to more distant targets in the forebrain and spinal cord.
[Mh] Termos MeSH primário: Anestésicos Gerais/administração & dosagem
Mesencéfalo/efeitos dos fármacos
Ponte/efeitos dos fármacos
Ponte/fisiologia
Inconsciência/induzido quimicamente
Inconsciência/fisiopatologia
[Mh] Termos MeSH secundário: Animais
Feminino
Masculino
Muscimol/administração & dosagem
Neurônios/efeitos dos fármacos
Ratos
Ratos Sprague-Dawley
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anesthetics, General); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170820
[St] Status:MEDLINE
[do] DOI:10.1523/JNEUROSCI.0544-17.2017


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[PMID]:28686124
[Au] Autor:Ivasyk I; Morgenstern PF; Wembacher-Schroeder E; Souweidane MM
[Ad] Endereço:Department of Neurological Surgery, NewYork-Presbyterian Hospital, Weill Cornell Medicine.
[Ti] Título:Influence of an intratumoral cyst on drug distribution by convection-enhanced delivery: case report.
[So] Source:J Neurosurg Pediatr;20(3):256-260, 2017 Sep.
[Is] ISSN:1933-0715
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Convection-enhanced delivery (CED) uses positive pressure to induce convective flow of molecules and maximize drug distribution. Concerns have been raised about the effect of cystic structures on uniform drug distribution with CED. The authors describe the case of a patient with a diffuse intrinsic pontine glioma (DIPG) with a large cyst and examine its effect on drug distribution after CED with a radiolabeled antibody. The patient was treated according to protocol with CED of I-8H9 to the pons for nonprogressive DIPG after radiation therapy as part of a Phase I trial (clinical trial registration no. NCT01502917, clinicaltrials.gov). Care was taken to avoid the cystic cavity in the planned catheter track and target point. Co-infusion with Gd-DTPA was performed to assess drug distribution. Infusate distribution was examined by MRI immediately following infusion and analyzed using iPlan Flow software. Analysis of postinfusion MR images demonstrated convective distribution around the catheter tip and an elongated configuration of drug distribution, consistent with the superoinferior corticospinal fiber orientation in the brainstem. This indicates that the catheter was functioning and a pressure gradient was established. No infusate entry into the cystic region could be identified on T2-weighted FLAIR or T1-weighted images. The effects of ependymal and pial surfaces on drug delivery using CED in brainstem tumors remain controversial. Drug distribution is a critical component of effective application of CED to neurosurgical lesions. This case suggests that cyst cavities may not always behave as fluid "sinks" for drug distribution. The authors observed that infusate was not lost into the cyst cavity, suggesting that lesions with cystic components can be treated by CED without significant alterations to target and infusion planning.
[Mh] Termos MeSH primário: Anticorpos Monoclonais/administração & dosagem
Antineoplásicos/administração & dosagem
Neoplasias do Tronco Encefálico/tratamento farmacológico
Cistos/metabolismo
Glioma/tratamento farmacológico
Ponte/efeitos dos fármacos
[Mh] Termos MeSH secundário: Anticorpos Monoclonais/farmacocinética
Antineoplásicos/farmacocinética
Neoplasias do Tronco Encefálico/diagnóstico por imagem
Neoplasias do Tronco Encefálico/metabolismo
Neoplasias do Tronco Encefálico/radioterapia
Criança
Cistos/diagnóstico por imagem
Sistemas de Liberação de Medicamentos
Feminino
Glioma/diagnóstico por imagem
Glioma/metabolismo
Glioma/radioterapia
Seres Humanos
Ponte/diagnóstico por imagem
Ponte/metabolismo
[Pt] Tipo de publicação:CASE REPORTS; CLINICAL TRIAL, PHASE I; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (8H9 monoclonal antibody); 0 (Antibodies, Monoclonal); 0 (Antineoplastic Agents)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE
[do] DOI:10.3171/2017.5.PEDS1774


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[PMID]:28609288
[Au] Autor:Osacka J; Horvathova L; Majercikova Z; Kiss A
[Ad] Endereço:.
[Ti] Título:Eff ect of a single asenapine treatment on Fos expression in the brain catecholamine-synthesizing neurons: impact of a chronic mild stress preconditioning.
[So] Source:Endocr Regul;51(2):73-83, 2017 Apr 25.
[Is] ISSN:1210-0668
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Fos protein expression in catecholamine-synthesizing neurons of the substantia nigra (SN) pars compacta (SNC, A8), pars reticulata (SNR, A9), and pars lateralis (SNL), the ventral tegmental area (VTA, A10), the locus coeruleus (LC, A6) and subcoeruleus (sLC), the ventrolateral pons (PON-A5), the nucleus of the solitary tract (NTS-A2), the area postrema (AP), and the ventrolateral medulla (VLM-A1) was quantitatively evaluated aft er a single administration of asenapine (ASE) (designated for schizophrenia treatment) in male Wistar rats preconditioned with a chronic unpredictable variable mild stress (CMS) for 21 days. Th e aim of the present study was to reveal whether a single ASE treatment may 1) activate Fos expression in the brain areas selected; 2) activate tyrosine hydroxylase (TH)-synthesizing cells displaying Fos presence; and 3) be modulated by CMS preconditioning. METHODS: Control (CON), ASE, CMS, and CMS+ASE groups were used. CMS included restraint, social isolation, crowding, swimming, and cold. Th e ASE and CMS+ASE groups received a single dose of ASE (0.3 mg/kg, s.c.) and CON and CMS saline (300 µl/rat, s.c.). The animals were sacrificed 90 min aft er the treatments. Fos protein and TH-labeled immunoreactive perikarya were analyzed on double labeled histological sections and enumerated on captured pictures using combined light and fluorescence microscope illumination. RESULTS: Saline or CMS alone did not promote Fos expression in any of the structures investigated. ASE alone or in combination with CMS elicited Fos expression in two parts of the SN (SNC, SNR) and the VTA. Aside from some cells in the central gray tegmental nuclei adjacent to LC, where a small number of Fos profiles occurred, none or negligible Fos occurrence was detected in the other structures investigated including the LC and sLC, PON-A5, NTS-A2, AP, and VLM-A1. CMS preconditioning did not infl uence the level of Fos induction in the SN and VTA elicited by ASE administration. Similarly, the ratio between the amount of free Fos and Fos colocalized with TH was not aff ected by stress preconditioning in the SNC, SNR, and the VTA. CONCLUSIONS: Th e present study provides an anatomical/functional knowledge about the nature of the acute ASE treatment on the catecholamine-synthesizing neurons activity in certain brain structures and their missing interplay with the CMS preconditioning.
[Mh] Termos MeSH primário: Antipsicóticos/farmacologia
Encéfalo/efeitos dos fármacos
Condicionamento (Psicologia)
Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia
Neurônios/efeitos dos fármacos
Proteínas Proto-Oncogênicas c-fos/efeitos dos fármacos
Estresse Psicológico/metabolismo
Tirosina 3-Mono-Oxigenase/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Área Postrema/citologia
Área Postrema/efeitos dos fármacos
Área Postrema/metabolismo
Encéfalo/citologia
Encéfalo/metabolismo
Catecolaminas/biossíntese
Imuno-Histoquímica
Locus Cerúleo/citologia
Locus Cerúleo/efeitos dos fármacos
Locus Cerúleo/metabolismo
Masculino
Bulbo/citologia
Bulbo/efeitos dos fármacos
Bulbo/metabolismo
Microscopia de Fluorescência
Neurônios/metabolismo
Parte Compacta da Substância Negra/citologia
Parte Compacta da Substância Negra/efeitos dos fármacos
Parte Compacta da Substância Negra/metabolismo
Parte Reticular da Substância Negra/citologia
Parte Reticular da Substância Negra/efeitos dos fármacos
Parte Reticular da Substância Negra/metabolismo
Ponte/citologia
Ponte/efeitos dos fármacos
Ponte/metabolismo
Proteínas Proto-Oncogênicas c-fos/metabolismo
Ratos
Ratos Wistar
Núcleo Solitário/citologia
Núcleo Solitário/efeitos dos fármacos
Núcleo Solitário/metabolismo
Estresse Psicológico/psicologia
Tirosina 3-Mono-Oxigenase/metabolismo
Área Tegmentar Ventral/citologia
Área Tegmentar Ventral/efeitos dos fármacos
Área Tegmentar Ventral/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antipsychotic Agents); 0 (Catecholamines); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Proto-Oncogene Proteins c-fos); EC 1.14.16.2 (Tyrosine 3-Monooxygenase); JKZ19V908O (Asenapine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE


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[PMID]:28532907
[Au] Autor:Cheng J; Meng J; Liu W; Zhang H; Lei D; Hui X
[Ad] Endereço:Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, China.
[Ti] Título:Nerve Atrophy and a Small Trigeminal Pontine Angle in Primary Trigeminal Neuralgia: A Morphometric Magnetic Resonance Imaging Study.
[So] Source:World Neurosurg;104:575-580, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To prospectively evaluate the morphological and structural changes in the trigeminal nerve in patients with trigeminal neuralgia (TN) compared with healthy controls. METHODS: We conducted a prospective case-control study of 60 consecutive patients diagnosed with TN and 30 sex-and age-matched healthy controls. All subjects underwent high-resolution 3-dimensional magnetic resonance imaging (MRI). The volume and length of the cisternal segment of the trigeminal nerve and the angle between the trigeminal nerve and the anterior surface of the pons (trigeminal pontine angle) were measured and compared. RESULTS: The mean volume of the affected trigeminal nerve was significantly reduced compared with that of the nonaffected side (65.8 ± 21.1 mm vs. 77.9 ± 19.3 mm ; P = 0.001) and controls (65.8 ± 21.1 mm vs. 74.7 ± 16.5 mm ; P = 0.003). The mean trigeminal pontine angle was 42.4 ± 8.7° on the affected side, 47.6 ± 9.2° on the nonaffected side, and 46.0 ± 7.2° in the controls. The trigeminal pontine angle on the affected side was significantly smaller than that on the nonaffected side (P = 0.005) and in controls (P = 0.01). There the was no statistically significant difference in the mean length of the cisternal segment of trigeminal nerve between the affected and nonaffected sides (P = 0.46). CONCLUSIONS: TN is associated with atrophy and a small trigeminal pontine angle in the affected nerve. Nerve atrophy may be a late consequence of chronic physical stress and is likely involved in the pathogenesis of TN. A small trigeminal pontine angle may increase the risk of neurovascular conflict, and thus more likely to result in the genesis of TN.
[Mh] Termos MeSH primário: Imagem Tridimensional
Imagem por Ressonância Magnética
Síndromes de Compressão Nervosa/diagnóstico por imagem
Síndromes de Compressão Nervosa/patologia
Ponte/diagnóstico por imagem
Ponte/cirurgia
Nervo Trigêmeo/diagnóstico por imagem
Nervo Trigêmeo/patologia
Neuralgia do Trigêmeo/diagnóstico por imagem
Neuralgia do Trigêmeo/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Atrofia
Estudos de Casos e Controles
Constrição Patológica/diagnóstico por imagem
Constrição Patológica/patologia
Constrição Patológica/cirurgia
Feminino
Seguimentos
Seres Humanos
Interpretação de Imagem Assistida por Computador
Masculino
Meia-Idade
Síndromes de Compressão Nervosa/cirurgia
Estudos Prospectivos
Valores de Referência
Fatores de Risco
Nervo Trigêmeo/cirurgia
Neuralgia do Trigêmeo/cirurgia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28529053
[Au] Autor:Shtaya A; Dabbous B; Fanou E; Bridges L; Hettige S
[Ad] Endereço:Academic Neurosurgery Unit, St George's, University of London, London; Department of Neurosurgery, Atkinson Morley Wing, St George's University Hospital, London, United Kingdom. Electronic address: ashtaya@sgul.ac.uk.
[Ti] Título:Unusual Intraparenchymal Pontomedullary Epidermoid Cyst in a 2-Year-Old Child: A Case Report and Review of the Literature.
[So] Source:World Neurosurg;104:1046.e15-1046.e20, 2017 Aug.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intrinsic brainstem epidermoid cysts are rare, benign, slow-growing lesions. Their eloquence precludes complete excision; however, subtotal resection often will result in prolonged or sometimes permanent relief of presenting symptoms and signs. We describe an unusual case and review the literature of this pathology in the pediatric population. CASE DESCRIPTION: We report an intra-axial pontine epidermoid cyst in a 2-year-old girl who presented with developmental delay, multiple cranial nerve palsies, and pneumonia. Magnetic resonance imaging demonstrated an intrinsic pontine lesion with partial restricted diffusion and an enhancing plaque, the latter not typically seen in congenital lesions like epidermoid. However, gross surgical inspection and histopathology confirmed an epidermoid. CONCLUSIONS: Our case, supported by the literature, shows that brain stem epidermoid cysts may have atypical radiologic characteristics and that near-total resection remains safe and can improve outcome.
[Mh] Termos MeSH primário: Encefalopatias/cirurgia
Cisto Epidérmico/cirurgia
Bulbo/cirurgia
Ponte/cirurgia
[Mh] Termos MeSH secundário: Encefalopatias/complicações
Encefalopatias/diagnóstico por imagem
Pré-Escolar
Doenças dos Nervos Cranianos/etiologia
Deficiências do Desenvolvimento/complicações
Cisto Epidérmico/complicações
Cisto Epidérmico/diagnóstico por imagem
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Bulbo/diagnóstico por imagem
Pneumonia Aspirativa/complicações
Ponte/diagnóstico por imagem
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE; REVIEW
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170523
[St] Status:MEDLINE


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[PMID]:28400488
[Au] Autor:Lapa S; Luger S; Pfeilschifter W; Henke C; Wagner M; Foerch C
[Ad] Endereço:From the Department of Neurology (S. Lapa, S. Luger, W.P., C.H., C.F.) and Institute of Neuroradiology (M.W.), Goethe University Frankfurt, Germany. sriramya.lapa@kgu.de.
[Ti] Título:Predictors of Dysphagia in Acute Pontine Infarction.
[So] Source:Stroke;48(5):1397-1399, 2017 May.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Little is known about the frequency and the clinical characteristics of neurogenic dysphagia in pontine strokes. In this study, we sought to identify predictors for dysphagia in a cohort of patients with isolated pontine infarctions. METHODS: We included all patients admitted to our department between 2008 and 2014 having an acute (<48 hours after symptom onset) ischemic stroke in the pons, as documented by means of diffusion-weighted magnetic resonance imaging. Precise infarct localization was stratified according to established vascular territories. The presence of dysphagia was the primary end point of the study and was assessed by a Speech-Language Pathologist according to defined criteria. RESULTS: The study recruited 59 patients, 14 with and 45 without dysphagia. Median (interquartile range) stroke severity (in terms of National Institutes of Health Stroke Scale values) was higher in the dysphagic group as compared with patients without dysphagia (8.5 [6-12] versus 2 [1-5]; <0.001). Infarct localization in the upper part of the pons (78.6% versus 33.3%; =0.004) and in the anterolateral vascular territory (78.6% versus 31.1%; =0.002) occurred more often in the dysphagic group. In a multivariate model, age, infarct volume, and National Institutes of Health Stroke Scale value were independent predictors of dysphagia. CONCLUSIONS: Dysphagia occurs frequently in patients with isolated pontine infarctions. Clinical and imaging predictors of dysphagia may help to provide optimal screening, to prevent complications and to improve long-term prognosis.
[Mh] Termos MeSH primário: Infartos do Tronco Encefálico/complicações
Infartos do Tronco Encefálico/diagnóstico por imagem
Transtornos de Deglutição/etiologia
Ponte/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Transtornos de Deglutição/diagnóstico
Imagem de Difusão por Ressonância Magnética
Feminino
Seres Humanos
Masculino
Meia-Idade
Prognóstico
Índice de Gravidade de Doença
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170413
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.116.015045



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