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[PMID]: 28031220 [Au] Autor: Schöberl F; Feil K; Xiong G; Bartenstein P; la Fougére C; Jahn K; Brandt T; Strupp M; Dieterich M; Zwergal A [Ad] Endereço: 1 Department of Neurology, Ludwig-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany. [Ti] Título: Pathological ponto-cerebello-thalamo-cortical activations in primary orthostatic tremor during lying and stance. [So] Source: Brain;140(1):83-97, 2017 01. [Is] ISSN: 1460-2156 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Primary orthostatic tremor is a rare neurological disease characterized mainly by a high frequency tremor of the legs while standing. The aim of this study was to identify the common core structures of the oscillatory circuit in orthostatic tremor and how it is modulated by changes of body position. Ten patients with orthostatic tremor and 10 healthy age-matched control subjects underwent a standardized neurological and neuro-ophthalmological examination including electromyographic and posturographic recordings. Task-dependent changes of cerebral glucose metabolism during lying and standing were measured in all subjects by sequential F-fluorodeoxyglucose-positron emission tomography on separate days. Results were compared between groups and conditions. All the orthostatic tremor patients, but no control subject, showed the characteristic 13-18 Hz tremor in coherent muscles during standing, which ceased in the supine position. While lying, patients had a significantly increased regional cerebral glucose metabolism in the pontine tegmentum, the posterior cerebellum (including the dentate nuclei), the ventral intermediate and ventral posterolateral nucleus of the thalamus, and the primary motor cortex bilaterally compared to controls. Similar glucose metabolism changes occurred with clinical manifestation of the tremor during standing. The glucose metabolism was relatively decreased in mesiofrontal cortical areas (i.e. the medial prefrontal cortex, supplementary motor area and anterior cingulate cortex) and the bilateral anterior insula in orthostatic tremor patients while lying and standing. The mesiofrontal hypometabolism correlated with increased body sway in posturography. This study confirms and further elucidates ponto-cerebello-thalamo-primary motor cortical activations underlying primary orthostatic tremor, which presented consistently in a group of patients. Compared to other tremor disorders one characteristic feature in orthostatic tremor seems to be the involvement of the pontine tegmentum in the pathophysiology of tremor generation. High frequency oscillatory properties of pontine tegmental neurons have been reported in pathological oscillatory eye movements. It is remarkable that the characteristic activation and deactivation pattern in orthostatic tremor is already present in the supine position without tremor presentation. Multilevel changes of neuronal excitability during upright stance may trigger activation of the orthostatic tremor network. Based on the functional imaging data described in this study, it is hypothesized that a mesiofrontal deactivation is another characteristic feature of orthostatic tremor and plays a pivotal role in development of postural unsteadiness during prolonged standing. [Mh] Termos MeSH primário: Cerebelo/diagnóstico por imagem Tontura/diagnóstico por imagem Córtex Motor/diagnóstico por imagem Tegmento Pontino/diagnóstico por imagem Tomografia por Emissão de Pósitrons/métodos Postura/fisiologia Núcleos Talâmicos/diagnóstico por imagem Tremor/diagnóstico por imagem [Mh] Termos MeSH secundário: Idoso Tontura/fisiopatologia Eletromiografia Feminino Seres Humanos Masculino Meia-Idade Equilíbrio Postural Tremor/fisiopatologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170917 [Lr] Data última revisão: 170917 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 161230 [St] Status: MEDLINE [do] DOI: 10.1093/brain/aww268

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[PMID]: 28010956 [Au] Autor: Isik U; Dinçer A [Ad] Endereço: Acibadem University, Department of Pediatrics, Division of Pediatric Neurology, Kozyatagi Acibadem Hastanesi, Inönü Cad. Okur Sok. No: 20, Kozyatagi, Istanbul, Turkey. Electronic address: ugur.isik@acibadem.com.tr. [Ti] Título: Central tegmentum tract hyperintensities in pediatric neurological patients: Incidence or coincidence. [So] Source: Brain Dev;39(5):411-417, 2017 May. [Is] ISSN: 1872-7131 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: AIM: The central tegmental tract hyperintensities (CTTH) have been found in many different pediatric neurological conditions. There is only scarce data about the value of this radiological phenomenon. In this study we aimed to show the neurological conditions associated with this radiological finding. MATERIALS AND METHODS: We performed a retrospective analysis of all pediatric brain MRI's between 2013 and 2015. After finding those patients with CTTH, we evaluated them in the pediatric neurology clinic. RESULTS: There were 41 out of 1464 brain MRI's with CTTH with 2.8% prevalence. Thirty four patients (23 male, age range 3months-98months) were available for evaluation. CTTH were present in mainly younger age group. There were many different neurological conditions associated with CTTH. These included brain tumors, epilepsy, developmental delay, metabolic disorders and genetic syndromes. CONCLUSION: CTTH is found in many different pediatric neurological conditions. Further neuropathological and prospective MRI and clinical studies are needed to better understand this interesting radiological finding. [Mh] Termos MeSH primário: Deficiências do Desenvolvimento/epidemiologia Doenças do Sistema Nervoso/diagnóstico por imagem Doenças do Sistema Nervoso/epidemiologia Tegmento Pontino/diagnóstico por imagem [Mh] Termos MeSH secundário: Adolescente Encefalopatias Metabólicas/diagnóstico por imagem Encefalopatias Metabólicas/epidemiologia Criança Pré-Escolar Deficiências do Desenvolvimento/diagnóstico por imagem Epilepsia/diagnóstico por imagem Epilepsia/epidemiologia Feminino Seres Humanos Processamento de Imagem Assistida por Computador Incidência Lactente Recém-Nascido Imagem por Ressonância Magnética Masculino Prevalência [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170417 [Lr] Data última revisão: 170417 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161225 [St] Status: MEDLINE

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[PMID]: 27977594 [Au] Autor: Jang SH; Chang CH; Jung YJ; Kwon HG [Ad] Endereço: aDepartment of Physical Medicine and Rehabilitation bDepartment of Neurosurgery, College of Medicine, Yeungnam University, Daemyung dong, Namku, Daegu, Republic of Korea. [Ti] Título: Severe ataxia due to injuries of neural tract detected by diffusion tensor tractography in a patient with pontine hemorrhage: A case report. [So] Source: Medicine (Baltimore);95(50):e5590, 2016 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: We examined injuries of the dentato-rubro-thalamic tract (DRTT), cortico-ponto-cerebellar tract (CPCT), dorsal spinocerebellar tract (SCT), and inferior cerebellar peduncle (ICP) in a patient with severe ataxia following bilateral tegmental pontine hemorrhage (PH), using diffusion tensor tractography (DTT). PATIENT CONCERNS: A 75-year-old female patient underwent conservative management for bilateral tegmental PH. She presented with moderate motor weakness, severe resting and intentional tremor on both hands, and severe truncal ataxia (Scale for Assessment and Rating of Ataxia [25 points/0-40 points: a higher score indicates a worse state]), and she was not able to sit independently. DIAGNOSES AND OUTCOMES: On DTT taken at 2 weeks after initial presentation, both DRTTs and the left dorsal SCT were not reconstructed, whereas the CPCTs showed thinning of the entire pathways between the primary sensorimotor cortex and cerebellum in both hemispheres. The right ICP was discontinued at the transverse cerebellar branch of the ICP and thinning of the left ICP was observed in the vertical and transverse cerebellar branch of the ICP. LESSONS: Using DTT, concurrent injuries of the DRTT, CPCT, dorsal SCT, and ICP were demonstrated in a patient with severe ataxia following PH. Our result suggests the necessity of evaluation of these neural tracts in patients who develop ataxia after brain injury. [Mh] Termos MeSH primário: Ataxia/etiologia Hemorragia Cerebral/complicações Tegmento Pontino [Mh] Termos MeSH secundário: Idoso Ataxia/diagnóstico Ataxia/diagnóstico por imagem Hemorragia Cerebral/diagnóstico Hemorragia Cerebral/diagnóstico por imagem Imagem de Tensor de Difusão/métodos Feminino Seres Humanos Neuroimagem Tegmento Pontino/irrigação sanguínea Tomografia Computadorizada por Raios X [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170224 [Lr] Data última revisão: 170224 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 161216 [St] Status: MEDLINE

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[PMID]: 27977583 [Au] Autor: Jang SH; Yeo SS [Ad] Endereço: aDepartment of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Gyeongsangbuk-do bDepartment of Physical Therapy, College of Health Sciences, Dankook University, Cheonan-si, Chungnam, Republic of Korea. [Ti] Título: Injury of the lower ascending reticular activating system in patients with pontine hemorrhage: Diffusion tensor imaging study. [So] Source: Medicine (Baltimore);95(50):e5527, 2016 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Many studies have reported about injury of the ascending reticular activating system (ARAS) in patients with various brain pathologies, using diffusion tensor tractography (DTT); however, little is known about injury of the ARAS in patients with pontine hemorrhage. In this study, using DTT, we attempted to investigate injury of the lower ventral and dorsal ARAS in patients with pontine hemorrhage. Twenty-three consecutive patients with pontine hemorrhage and 14 control subjects were recruited into this study. The patients were classified into 2 subgroups on the basis of the preservation of arousal: subgroup A (14 patients)-intact arousal, subgroup B (9 patients)-impaired arousal. The lower ventral and dorsal ARAS between the pontine reticular formation with hypothalamus and thalamic intralaminar nucleus were reconstructed. Fractional anisotropy (FA), mean diffusivity (MD), and tract volume (TV) values were measured. The TVs of the lower ventral and dorsal ARAS were significantly lower in subgroup B than in the subgroup A and control group (P < 0.05). In terms of FA value, the lower dorsal ARAS were significantly lower in subgroup A and subgroup B than in the control group (P < 0.05). In conclusion, injury of the lower ventral and dorsal ARAS was demonstrated in patients with impaired arousal following pontine hemorrhage. We believe that analysis of the ARAS using DTT would be helpful in evaluation of patients with impaired consciousness after pontine hemorrhage. [Mh] Termos MeSH primário: Imagem de Tensor de Difusão/métodos Hemorragias Intracranianas/diagnóstico por imagem Tegmento Pontino/lesões Acidente Vascular Cerebral/diagnóstico por imagem [Mh] Termos MeSH secundário: Adulto Estudos de Casos e Controles Feminino Escala de Coma de Glasgow Seres Humanos Hemorragias Intracranianas/mortalidade Masculino Meia-Idade Prognóstico Medição de Risco Índice de Gravidade de Doença Taxa de Sobrevida [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE; OBSERVATIONAL STUDY [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170224 [Lr] Data última revisão: 170224 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 161216 [St] Status: MEDLINE

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[PMID]: 27957531 [Au] Autor: Khanday MA; Somarajan BI; Mehta R; Mallick BN [Ad] Endereço: School of Life Sciences, Jawaharlal Nehru University , New Delhi 110607, India. [Ti] Título: Noradrenaline from Locus Coeruleus Neurons Acts on Pedunculo-Pontine Neurons to Prevent REM Sleep and Induces Its Loss-Associated Effects in Rats. [So] Source: eNeuro;3(6), 2016 Nov-Dec. [Is] ISSN: 2373-2822 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Normally, rapid eye movement sleep (REMS) does not appear during waking or non-REMS. Isolated, independent studies showed that elevated noradrenaline (NA) levels inhibit REMS and induce REMS loss-associated cytomolecular, cytomorphological, psychosomatic changes and associated symptoms. However, the source of NA and its target in the brain for REMS regulation and function in health and diseases remained to be confirmed . Using tyrosine hydroxylase (TH)-siRNA and virus-coated TH-shRNA in normal freely moving rats, we downregulated NA synthesis in locus coeruleus (LC) REM-OFF neurons . These TH-downregulated rats showed increased REMS, which was prevented by infusing NA into the pedunculo-pontine tegmentum (PPT), the site of REM-ON neurons, normal REMS returned after recovery. Moreover, unlike normal or control-siRNA- or shRNA-injected rats, upon REMS deprivation (REMSD) TH-downregulated rat brains did not show elevated Na-K ATPase (molecular changes) expression and activity. To the best of our knowledge, these are the first findings in an animal model confirming that NA from the LC REM-OFF neurons (1) acts on the PPT REM-ON neurons to prevent appearance of REMS, and (2) are responsible for inducing REMSD-associated molecular changes and symptoms. These observations clearly show neuro-physio-chemical mechanism of why normally REMS does not appear during waking. Also, that LC neurons are the primary source of NA, which in turn causes some, if not many, REMSD-associated symptoms and behavioral changes. The findings are proof-of-principle for the first time and hold potential to be exploited for confirmation toward treating REMS disorder and amelioration of REMS loss-associated symptoms in patients. [Mh] Termos MeSH primário: Locus Cerúleo/metabolismo Neurônios/metabolismo Norepinefrina/metabolismo Núcleo Tegmental Pedunculopontino/metabolismo Tegmento Pontino/metabolismo Sono REM/fisiologia [Mh] Termos MeSH secundário: Animais Masculino Neurônios/patologia Núcleo Tegmental Pedunculopontino/patologia Tegmento Pontino/patologia RNA Mensageiro/metabolismo RNA Interferente Pequeno/genética Ratos Wistar Privação do Sono/metabolismo Privação do Sono/patologia ATPase Trocadora de Sódio-Potássio/metabolismo Tirosina 3-Mono-Oxigenase/antagonistas & inibidores Tirosina 3-Mono-Oxigenase/genética Tirosina 3-Mono-Oxigenase/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (RNA, Messenger); 0 (RNA, Small Interfering); EC 1.14.16.2 (Tyrosine 3-Monooxygenase); EC 3.6.3.9 (Sodium-Potassium-Exchanging ATPase); X4W3ENH1CV (Norepinephrine) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171024 [Lr] Data última revisão: 171024 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161214 [St] Status: MEDLINE

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[PMID]: 27930506 [Au] Autor: Jang SH; Chang CH; Jung YJ; Seo YS [Ad] Endereço: aDepartment of Physical Medicine and Rehabilitation bDepartment of Neurosurgery, College of Medicine, Yeungnam University, Taegu, Republic of Korea. [Ti] Título: Change of ascending reticular activating system with recovery from vegetative state to minimally conscious state in a stroke patient. [So] Source: Medicine (Baltimore);95(49):e5234, 2016 Dec. [Is] ISSN: 1536-5964 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: RATIONALE: We report on a stroke patient who showed change of the ascending reticular activating system (ARAS) concurrent with recovery from a vegetative state (VS) to a minimally conscious state (MCS), which was demonstrated on diffusion tensor tractography (DTT). PATIENT CONCERNS: A 59-year-old male patient underwent CT-guided stereotactic drainage 3 times for management of intracerebral hemorrhage and intraventricular hemorrhage. DIAGNOSIS: After 4 months from onset, when starting rehabilitation, the patient showed impaired consciousness, with a Glasgow Coma Scale (GCS) score of 6 and a Coma Recovery Scale-Revised score of 2. At 10 months after onset, his GCS score had recovered to 11 with a GRS-R score of 20, and he was able to perform rock-scissors-paper using his right hand according to verbal command. INTERVENTIONS: On 10-month DTT, marked increased neural connectivity of the thalamic intralaminar nucleus (ILN) to the cerebral cortex was observed in both prefrontal cortexes and the right thalamus compared with 4-month DTT. However, no significant change was observed in the lower dorsal ARAS between the pontine reticular formation (PRF) and the thalamic ILN. In addition, the reconstructed lower ventral ARAS between the PRF and hypothalamus had disappeared in both hemispheres on 10-month DTT. OUTCOMES: Change of the ARAS was demonstrated in a stroke patient who showed recovery from a VS to an MCS. LESSONS: It appeared that the prefrontal cortex and thalamus, which showed increased neural connectivity, contributed to recovery from a VS to an MCS in this patient. [Mh] Termos MeSH primário: Estado de Consciência Estado Vegetativo Persistente/fisiopatologia Tegmento Pontino/fisiologia Acidente Vascular Cerebral/patologia [Mh] Termos MeSH secundário: Imagem de Tensor de Difusão Seguimentos Escala de Coma de Glasgow Seres Humanos Masculino Meia-Idade Estado Vegetativo Persistente/etiologia Estado Vegetativo Persistente/terapia Recuperação de Função Fisiológica Medição de Risco Acidente Vascular Cerebral/complicações Acidente Vascular Cerebral/diagnóstico Fatores de Tempo Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170224 [Lr] Data última revisão: 170224 [Sb] Subgrupo de revista: AIM; IM [Da] Data de entrada para processamento: 161209 [St] Status: MEDLINE

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[PMID]: 27645362 [Au] Autor: Koutsis G; Kokotis P; Papagianni AE; Evangelopoulos ME; Kilidireas C; Karandreas N [Ad] Endereço: 1st Department of Neurology, Eginition Hospital, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: gkoutsi2@otenet.gr. [Ti] Título: A neurophysiological study of facial numbness in multiple sclerosis: Integration with clinical data and imaging findings. [So] Source: Mult Scler Relat Disord;9:140-6, 2016 Sep. [Is] ISSN: 2211-0356 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To integrate neurophysiological findings with clinical and imaging data in a consecutive series of multiple sclerosis (MS) patients developing facial numbness during the course of an MS attack. METHODS: Nine consecutive patients with MS and recent-onset facial numbness were studied clinically, imaged with routine MRI, and assessed neurophysiologically with trigeminal somatosensory evoked potential (TSEP), blink reflex (BR), masseter reflex (MR), facial nerve conduction, facial muscle and masseter EMG studies. RESULTS: All patients had unilateral facial hypoesthesia on examination and lesions in the ipsilateral pontine tegmentum on MRI. All patients had abnormal TSEPs upon stimulation of the affected side, excepting one that was tested following remission of numbness. BR was the second most sensitive neurophysiological method with 6/9 examinations exhibiting an abnormal R1 component. The MR was abnormal in 3/6 patients, always on the affected side. Facial conduction and EMG studies were normal in all patients but one. CONCLUSIONS: Facial numbness was always related to abnormal TSEPs. A concomitant R1 abnormality on BR allowed localization of the responsible pontine lesion, which closely corresponded with MRI findings. We conclude that neurophysiological assessment of MS patients with facial numbness is a sensitive tool, which complements MRI, and can improve lesion localization. [Mh] Termos MeSH primário: Potenciais Somatossensoriais Evocados Hipestesia/diagnóstico por imagem Hipestesia/fisiopatologia Esclerose Múltipla/diagnóstico por imagem Esclerose Múltipla/fisiopatologia Tegmento Pontino/diagnóstico por imagem [Mh] Termos MeSH secundário: Adulto Piscadela Eletromiografia Face/fisiopatologia Músculos Faciais/fisiopatologia Nervo Facial/fisiopatologia Feminino Seres Humanos Hipestesia/complicações Imagem por Ressonância Magnética Masculino Músculo Masseter/fisiopatologia Meia-Idade Esclerose Múltipla/complicações Condução Nervosa Reflexo Nervo Trigêmeo/fisiopatologia Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170228 [Lr] Data última revisão: 170228 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160921 [St] Status: MEDLINE

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[PMID]: 27594407 [Au] Autor: Kang HG; Cheong JS; An H [Ad] Endereço: Department of Neurology, Chosun University School of Medicine and Hospital, Gwangju, South Korea. [Ti] Título: Acute pontine infarction presenting with depressive mood only. [So] Source: Geriatr Gerontol Int;16(9):1085-6, 2016 Sep. [Is] ISSN: 1447-0594 [Cp] País de publicação: Japan [La] Idioma: eng [Mh] Termos MeSH primário: Infarto Cerebral/diagnóstico Depressão/diagnóstico Angiografia por Ressonância Magnética/métodos Tegmento Pontino/diagnóstico por imagem [Mh] Termos MeSH secundário: Idoso Diagnóstico Diferencial Seres Humanos Masculino Transtornos do Humor/diagnóstico Tegmento Pontino/patologia [Pt] Tipo de publicação: CASE REPORTS; LETTER [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170626 [Lr] Data última revisão: 170626 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160906 [St] Status: MEDLINE [do] DOI: 10.1111/ggi.12643

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[PMID]: 27448046 [Au] Autor: Zhang L; Xu Y; Zhuang J; Peng H; Wu H; Zhao Z; He B; Zhao Z [Ad] Endereço: Department of Neurology, ChangZheng Hospital Affiliated with the Second Military Medical University, Shanghai 200003, China. [Ti] Título: Metabolic abnormality of pontine tegmentum in patients with REM sleep behavior disorder analyzed using magnetic resonance spectroscopy. [So] Source: Clin Neurol Neurosurg;148:137-41, 2016 Sep. [Is] ISSN: 1872-6968 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: OBJECTIVES: We aimed to evaluate the metabolism differences in pontine tegmentum among patients with idiopathic RBD (iRBD), secondary RBD (sRBD) and healthy control groups using magnetic resonance spectroscopy ((1)H-MRS) and whether metabolic changes are correlated with age in patients with RBD. PATIENTS AND METHODS: The iRBD, sRBD, and control groups were composed of 18, 26, and 29 patients, respectively. All participants underwent magnetic resonance imaging (MRI) and (1)H-MRS detection at 17:00 for approximately 15min. All NAA/Cr, Cho/Cr and NAA/Cho ratios were automatically generated using FuncTool and the correlation between metabolism and age was analyzed by Pearson's correlation analysis. RESULTS: Significant difference in NAA/Cr ratio was found between the sRBD group and the other groups (p<0.05). Significant difference in NAA/Cho ratio was found among all groups (p<0.05). Cho/Cr ratio remarkably increased in the control group (p<0.05) compared with the other groups. NAA/Cr ratio had an adverse correlation with age in the control, iRBD, and sRBD groups (r=-0.822, p=0.000 vs r=-0.663, p=0.003 vs r=-0.583, p=0.002). However, there was no correlation between participants age and Cho/Cr (r=-0.054, p=0.651) or NAA/Cho (r=0.029, p=0.805). CONCLUSION: Neurons in the sRBD group were lost or damaged; however, this damage was not obvious in the iRBD group. Nevertheless, NAA and Cho levels were reduced in the local nerve cells of both RBD groups; these changes might indicate the sensitive pathogenic areas among patients with RBD. [Mh] Termos MeSH primário: Ácido Aspártico/análogos & derivados Colina/metabolismo Creatina/metabolismo Tegmento Pontino/metabolismo Espectroscopia de Prótons por Ressonância Magnética/métodos Transtorno do Comportamento do Sono REM/metabolismo [Mh] Termos MeSH secundário: Idoso Ácido Aspártico/metabolismo Feminino Seres Humanos Masculino Meia-Idade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 30KYC7MIAI (Aspartic Acid); 997-55-7 (N-acetylaspartate); MU72812GK0 (Creatine); N91BDP6H0X (Choline) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160723 [St] Status: MEDLINE

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[PMID]: 27318368 [Au] Autor: Kong WY; Tan YQ; Sia CH; Chee QZ; Yeo LL [Ad] Endereço: Division of Neurology, Department of Medicine, National University Health System, 1E Kent Ridge Road, Singapore 119228. [Ti] Título: Adding up cranial nerves to localize the lesion: eight-and-a-half syndrome. [So] Source: QJM;109(9):627-8, 2016 Sep. [Is] ISSN: 1460-2393 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Aspirina/administração & dosagem Paralisia de Bell Técnicas de Diagnóstico Oftalmológico Diplopia Inibidores de Hidroximetilglutaril-CoA Redutases/administração & dosagem Exame Neurológico/métodos Tegmento Pontino/diagnóstico por imagem [Mh] Termos MeSH secundário: Paralisia de Bell/diagnóstico Paralisia de Bell/etiologia Paralisia de Bell/fisiopatologia Infartos do Tronco Encefálico/complicações Infartos do Tronco Encefálico/diagnóstico Infartos do Tronco Encefálico/tratamento farmacológico Diplopia/diagnóstico Diplopia/etiologia Diplopia/fisiopatologia Nervo Facial/fisiopatologia Seres Humanos Masculino Meia-Idade Inibidores da Agregação de Plaquetas/administração & dosagem Síndrome Resultado do Tratamento [Pt] Tipo de publicação: CASE REPORTS; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors); 0 (Platelet Aggregation Inhibitors); R16CO5Y76E (Aspirin) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170309 [Lr] Data última revisão: 170309 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160619 [St] Status: MEDLINE [do] DOI: 10.1093/qjmed/hcw096

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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