[PMID]: | 27448046 |
[Au] Autor: | Zhang L; Xu Y; Zhuang J; Peng H; Wu H; Zhao Z; He B; Zhao Z |
[Ad] Endereço: | Department of Neurology, ChangZheng Hospital Affiliated with the Second Military Medical University, Shanghai 200003, China. |
[Ti] Título: | Metabolic abnormality of pontine tegmentum in patients with REM sleep behavior disorder analyzed using magnetic resonance spectroscopy. |
[So] Source: | Clin Neurol Neurosurg;148:137-41, 2016 Sep. |
[Is] ISSN: | 1872-6968 |
[Cp] País de publicação: | Netherlands |
[La] Idioma: | eng |
[Ab] Resumo: | OBJECTIVES: We aimed to evaluate the metabolism differences in pontine tegmentum among patients with idiopathic RBD (iRBD), secondary RBD (sRBD) and healthy control groups using magnetic resonance spectroscopy ((1)H-MRS) and whether metabolic changes are correlated with age in patients with RBD. PATIENTS AND METHODS: The iRBD, sRBD, and control groups were composed of 18, 26, and 29 patients, respectively. All participants underwent magnetic resonance imaging (MRI) and (1)H-MRS detection at 17:00 for approximately 15min. All NAA/Cr, Cho/Cr and NAA/Cho ratios were automatically generated using FuncTool and the correlation between metabolism and age was analyzed by Pearson's correlation analysis. RESULTS: Significant difference in NAA/Cr ratio was found between the sRBD group and the other groups (p<0.05). Significant difference in NAA/Cho ratio was found among all groups (p<0.05). Cho/Cr ratio remarkably increased in the control group (p<0.05) compared with the other groups. NAA/Cr ratio had an adverse correlation with age in the control, iRBD, and sRBD groups (r=-0.822, p=0.000 vs r=-0.663, p=0.003 vs r=-0.583, p=0.002). However, there was no correlation between participants age and Cho/Cr (r=-0.054, p=0.651) or NAA/Cho (r=0.029, p=0.805). CONCLUSION: Neurons in the sRBD group were lost or damaged; however, this damage was not obvious in the iRBD group. Nevertheless, NAA and Cho levels were reduced in the local nerve cells of both RBD groups; these changes might indicate the sensitive pathogenic areas among patients with RBD. |
[Mh] Termos MeSH primário: |
Ácido Aspártico/análogos & derivados Colina/metabolismo Creatina/metabolismo Tegmento Pontino/metabolismo Espectroscopia de Prótons por Ressonância Magnética/métodos Transtorno do Comportamento do Sono REM/metabolismo
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[Mh] Termos MeSH secundário: |
Idoso Ácido Aspártico/metabolismo Feminino Seres Humanos Masculino Meia-Idade
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[Pt] Tipo de publicação: | JOURNAL ARTICLE |
[Nm] Nome de substância:
| 30KYC7MIAI (Aspartic Acid); 997-55-7 (N-acetylaspartate); MU72812GK0 (Creatine); N91BDP6H0X (Choline) |
[Em] Mês de entrada: | 1703 |
[Cu] Atualização por classe: | 170817 |
[Lr] Data última revisão:
| 170817 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 160723 |
[St] Status: | MEDLINE |
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