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[PMID]:28451633
[Au] Autor:Chrastil ER; Sherrill KR; Aselcioglu I; Hasselmo ME; Stern CE
[Ad] Endereço:Department of Psychological and Brain Sciences and Center for Memory and Brain, Boston University, Boston, MA.
[Ti] Título:Individual Differences in Human Path Integration Abilities Correlate with Gray Matter Volume in Retrosplenial Cortex, Hippocampus, and Medial Prefrontal Cortex.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Humans differ in their individual navigational abilities. These individual differences may exist in part because successful navigation relies on several disparate abilities, which rely on different brain structures. One such navigational capability is path integration, the updating of position and orientation, in which navigators track distances, directions, and locations in space during movement. Although structural differences related to landmark-based navigation have been examined, gray matter volume related to path integration ability has not yet been tested. Here, we examined individual differences in two path integration paradigms: (1) a location tracking task and (2) a task tracking translational and rotational self-motion. Using voxel-based morphometry, we related differences in performance in these path integration tasks to variation in brain morphology in 26 healthy young adults. Performance in the location tracking task positively correlated with individual differences in gray matter volume in three areas critical for path integration: the hippocampus, the retrosplenial cortex, and the medial prefrontal cortex. These regions are consistent with the path integration system known from computational and animal models and provide novel evidence that morphological variability in retrosplenial and medial prefrontal cortices underlies individual differences in human path integration ability. The results for tracking rotational self-motion-but not translation or location-demonstrated that cerebellum gray matter volume correlated with individual performance. Our findings also suggest that these three aspects of path integration are largely independent. Together, the results of this study provide a link between individual abilities and the functional correlates, computational models, and animal models of path integration.
[Mh] Termos MeSH primário: Substância Cinzenta/anatomia & histologia
Hipocampo/anatomia & histologia
Córtex Pré-Frontal/anatomia & histologia
Navegação Espacial/fisiologia
[Mh] Termos MeSH secundário: Adulto
Mapeamento Encefálico
Córtex Cerebral/anatomia & histologia
Córtex Cerebral/fisiologia
Feminino
Substância Cinzenta/fisiologia
Hipocampo/fisiologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Percepção de Movimento/fisiologia
Estimulação Luminosa
Córtex Pré-Frontal/fisiologia
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


  2 / 1771 MEDLINE  
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[PMID]:27778099
[Au] Autor:Fiorenzato E; Weis L; Seppi K; Onofrj M; Cortelli P; Zanigni S; Tonon C; Kaufmann H; Shepherd TM; Poewe W; Krismer F; Wenning G; Antonini A; Biundo R; Movement Disorders Society MSA (MODIMSA) Neuropsychology and Imaging Study Groups
[Ad] Endereço:Parkinson Disease and Movement Disorders Unit, IRCCS San Camillo Hospital Foundation, via Alberoni, 70, 30126, Venice-Lido, Italy. eleonora.fiorenzato@gmail.com.
[Ti] Título:Brain structural profile of multiple system atrophy patients with cognitive impairment.
[So] Source:J Neural Transm (Vienna);124(3):293-302, 2017 Mar.
[Is] ISSN:1435-1463
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Current consensus diagnostic criteria for multiple system atrophy (MSA) consider dementia a non-supporting feature, although cognitive impairment and even frank dementia are reported in clinical practice. Mini-Mental State Examination (MMSE) is a commonly used global cognitive scale, and in a previous study, we established an MSA-specific screening cut-off score <27 to identify cognitive impairment. Finally, MSA neuroimaging findings suggest the presence of structural alterations in patients with cognitive deficits, although the extent of the anatomical changes is unclear. The aim of our multicenter study is to better characterize anatomical changes associated with cognitive impairment in MSA and to further investigate cortical and subcortical structural differences versus healthy controls (HC). We examined retrospectively 72 probable MSA patients [50 with normal cognition (MSA-NC) and 22 cognitively impaired (MSA-CI) based on MMSE <27] and compared them to 36 HC using gray- and white-matter voxel-based morphometry and fully automated subcortical segmentation. Compared to HC, MSA patients showed widespread cortical (bilateral frontal, occipito-temporal, and parietal areas), subcortical, and white-matter alterations. However, MSA-CI showed only focal volume reduction in the left dorsolateral prefrontal cortex compared with MSA-NC. These results suggest only a marginal contribution of cortical pathology to cognitive deficits. We believe that cognitive dysfunction is driven by focal fronto-striatal degeneration in line with the concept of "subcortical cognitive impairment".
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Disfunção Cognitiva/complicações
Disfunção Cognitiva/diagnóstico por imagem
Atrofia de Múltiplos Sistemas/complicações
Atrofia de Múltiplos Sistemas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Feminino
Substância Cinzenta/diagnóstico por imagem
Seres Humanos
Imagem Tridimensional
Imagem por Ressonância Magnética
Masculino
Testes de Estado Mental e Demência
Meia-Idade
Atrofia de Múltiplos Sistemas/psicologia
Neuroimagem
Tamanho do Órgão
Reconhecimento Automatizado de Padrão
Estudos Retrospectivos
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s00702-016-1636-0


  3 / 1771 MEDLINE  
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[PMID]:29261693
[Au] Autor:Evia AM; Kotrotsou A; Tamhane AA; Dawe RJ; Kapasi A; Leurgans SE; Schneider JA; Bennett DA; Arfanakis K
[Ad] Endereço:Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States of America.
[Ti] Título:Ex-vivo quantitative susceptibility mapping of human brain hemispheres.
[So] Source:PLoS One;12(12):e0188395, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ex-vivo brain quantitative susceptibility mapping (QSM) allows investigation of brain characteristics at essentially the same point in time as histopathologic examination, and therefore has the potential to become an important tool for determining the role of QSM as a diagnostic and monitoring tool of age-related neuropathologies. In order to be able to translate the ex-vivo QSM findings to in-vivo, it is crucial to understand the effects of death and chemical fixation on brain magnetic susceptibility measurements collected ex-vivo. Thus, the objective of this work was twofold: a) to assess the behavior of magnetic susceptibility in both gray and white matter of human brain hemispheres as a function of time postmortem, and b) to establish the relationship between in-vivo and ex-vivo gray matter susceptibility measurements on the same hemispheres. Five brain hemispheres from community-dwelling older adults were imaged ex-vivo with QSM on a weekly basis for six weeks postmortem, and the longitudinal behavior of ex-vivo magnetic susceptibility in both gray and white matter was assessed. The relationship between in-vivo and ex-vivo gray matter susceptibility measurements was investigated using QSM data from eleven older adults imaged both antemortem and postmortem. No systematic change in ex-vivo magnetic susceptibility of gray or white matter was observed over time postmortem. Additionally, it was demonstrated that, gray matter magnetic susceptibility measured ex-vivo may be well modeled as a linear function of susceptibility measured in-vivo. In conclusion, magnetic susceptibility in gray and white matter measured ex-vivo with QSM does not systematically change in the first six weeks after death. This information is important for future cross-sectional ex-vivo QSM studies of hemispheres imaged at different postmortem intervals. Furthermore, the linear relationship between in-vivo and ex-vivo gray matter magnetic susceptibility suggests that ex-vivo QSM captures information linked to antemortem gray matter magnetic susceptibility, which is important for translation of ex-vivo QSM findings to in-vivo.
[Mh] Termos MeSH primário: Mapeamento Encefálico/métodos
[Mh] Termos MeSH secundário: Adulto
Feminino
Substância Cinzenta/diagnóstico por imagem
Seres Humanos
Interpretação de Imagem Assistida por Computador
Imagem por Ressonância Magnética
Masculino
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180214
[Lr] Data última revisão:
180214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171221
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0188395


  4 / 1771 MEDLINE  
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[PMID]:29304183
[Au] Autor:Rektor I; Svátková A; Vojtísek L; Zikmundová I; Vanícek J; Király A; Szabó N
[Ad] Endereço:Movement Disorders Center; First Department of Neurology, School of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic.
[Ti] Título:White matter alterations in Parkinson's disease with normal cognition precede grey matter atrophy.
[So] Source:PLoS One;13(1):e0187939, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: While progressive MRI brain changes characterize advanced Parkinson's disease (PD), little has been discovered about structural alterations in the earliest phase of the disease, i.e. in patients with motor symptoms and with normal cognition. Our study aimed to detect grey matter (GM) and white matter (WM) changes in PD patients without cognitive impairment. METHODS: Twenty PD patients and twenty-one healthy controls (HC) were tested for attention, executive function, working memory, and visuospatial and language domains. High-resolution T1-weighted and 60 directional diffusion-weighted 3T MRI images were acquired. The cortical, deep GM and WM volumes and density, as well as the diffusion properties of WM, were calculated. Analyses were repeated on data flipped to the side of the disease origin. RESULTS: PD patients did not show any significant differences from HC in cognitive functioning or in brain volumes. Decreased GM intensity was found in the left superior parietal lobe in the right (p<0.02) and left (p<0.01) flipped data. The analysis of original, un-flipped data demonstrated elevated axial diffusivity (p<0.01) in the superior and anterior corona radiata, internal capsule, and external capsule in the left hemisphere of PD relative to HC, while higher mean and radial diffusivity were discovered in the right (p<0.02 and p<0.03, respectively) and left (p<0.02 and p<0.02, respectively) in the fronto-temporal WM utilizing flipped data. CONCLUSIONS: PD patients without cognitive impairment and GM atrophy demonstrated widespread alterations of WM microstructure. Thus, WM impairment in PD might be a sensitive sign preceding the neuronal loss in associated GM regions.
[Mh] Termos MeSH primário: Substância Cinzenta/patologia
Doença de Parkinson/patologia
Doença de Parkinson/psicologia
Substância Branca/patologia
[Mh] Termos MeSH secundário: Adulto
Idoso
Atrofia
Estudos de Casos e Controles
Cognição
Progressão da Doença
Feminino
Substância Cinzenta/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Neuroimagem
Testes Neuropsicológicos
Doença de Parkinson/diagnóstico por imagem
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0187939


  5 / 1771 MEDLINE  
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[PMID]:29304050
[Au] Autor:Yoneyama N; Watanabe H; Kawabata K; Bagarinao E; Hara K; Tsuboi T; Tanaka Y; Ohdake R; Imai K; Masuda M; Hattori T; Ito M; Atsuta N; Nakamura T; Hirayama M; Maesawa S; Katsuno M; Sobue G
[Ad] Endereço:Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
[Ti] Título:Severe hyposmia and aberrant functional connectivity in cognitively normal Parkinson's disease.
[So] Source:PLoS One;13(1):e0190072, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Severe hyposmia is a risk factor of dementia in Parkinson's disease (PD), while the underlying functional connectivity (FC) and brain volume alterations in PD patients with severe hyposmia (PD-SH) are unclear. METHODS: We examined voxel-based morphometric and resting state functional magnetic resonance imaging findings in 15 cognitively normal PD-SH, 15 cognitively normal patients with PD with no/mild hyposmia (PD-N/MH), and 15 healthy controls (HCs). RESULTS: Decreased gray matter volume (GMV) was observed in the bilateral cuneus, right associative visual area, precuneus, and some areas in anterior temporal lobes in PD-SH group compared to HCs. Both the PD-SH and PD-N/MH groups showed increased GMV in the bilateral posterior insula and its surrounding regions. A widespread significant decrease in amygdala FC beyond the decreased GMV areas and olfactory cortices were found in the PD-SH group compared with the HCs. Above all, decreased amygdala FC with the inferior parietal lobule, lingual gyrus, and fusiform gyrus was significantly correlated with both reduction of Addenbrooke's Cognitive Examination-Revised scores and severity of hyposmia in all participants. Canonical resting state networks exhibited decreased FC in the precuneus and left executive control networks but increased FC in the primary and high visual networks of patients with PD compared with HCs. Canonical network FC to other brain regions was enhanced in the executive control, salience, primary visual, and visuospatial networks of the PD-SH. CONCLUSION: PD-SH showed extensive decreased amygdala FC. Particularly, decreased FC between the amygdala and inferior parietal lobule, lingual gyrus, and fusiform gyrus were associated with the severity of hyposmia and cognitive performance. In contrast, relatively preserved canonical networks in combination with increased FC to brain regions outside of canonical networks may be related to compensatory mechanisms, and preservation of brain function.
[Mh] Termos MeSH primário: Mapeamento Encefálico/métodos
Cognição
Transtornos do Olfato/fisiopatologia
Doença de Parkinson/fisiopatologia
[Mh] Termos MeSH secundário: Idoso
Feminino
Substância Cinzenta/diagnóstico por imagem
Substância Cinzenta/fisiopatologia
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Doença de Parkinson/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190072


  6 / 1771 MEDLINE  
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[PMID]:29250547
[Au] Autor:Sandhya G; Babu Kande G; Savithri TS
[Ad] Endereço:Department of ECE, VNITSW, Guntur, Andhra Pradesh, India.
[Ti] Título:Multilevel Thresholding Method Based on Electromagnetism for Accurate Brain MRI Segmentation to Detect White Matter, Gray Matter, and CSF.
[So] Source:Biomed Res Int;2017:6783209, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This work explains an advanced and accurate brain MRI segmentation method. MR brain image segmentation is to know the anatomical structure, to identify the abnormalities, and to detect various tissues which help in treatment planning prior to radiation therapy. This proposed technique is a Multilevel Thresholding (MT) method based on the phenomenon of Electromagnetism and it segments the image into three tissues such as White Matter (WM), Gray Matter (GM), and CSF. The approach incorporates skull stripping and filtering using anisotropic diffusion filter in the preprocessing stage. This thresholding method uses the force of attraction-repulsion between the charged particles to increase the population. It is the combination of Electromagnetism-Like optimization algorithm with the Otsu and Kapur objective functions. The results obtained by using the proposed method are compared with the ground-truth images and have given best values for the measures sensitivity, specificity, and segmentation accuracy. The results using 10 MR brain images proved that the proposed method has accurately segmented the three brain tissues compared to the existing segmentation methods such as -means, fuzzy -means, OTSU MT, Particle Swarm Optimization (PSO), Bacterial Foraging Algorithm (BFA), Genetic Algorithm (GA), and Fuzzy Local Gaussian Mixture Model (FLGMM).
[Mh] Termos MeSH primário: Líquido Cefalorraquidiano/diagnóstico por imagem
Substância Cinzenta/diagnóstico por imagem
Processamento de Imagem Assistida por Computador/métodos
Imagem por Ressonância Magnética/métodos
Substância Branca/diagnóstico por imagem
[Mh] Termos MeSH secundário: Algoritmos
Análise por Conglomerados
Lógica Fuzzy
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180129
[Lr] Data última revisão:
180129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171219
[St] Status:MEDLINE
[do] DOI:10.1155/2017/6783209


  7 / 1771 MEDLINE  
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[PMID]:27777415
[Au] Autor:Greene DJ; Williams Iii AC; Koller JM; Schlaggar BL; Black KJ
[Ad] Endereço:Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
[Ti] Título:Brain structure in pediatric Tourette syndrome.
[So] Source:Mol Psychiatry;22(7):972-980, 2017 Jul.
[Is] ISSN:1476-5578
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Previous studies of brain structure in Tourette syndrome (TS) have produced mixed results, and most had modest sample sizes. In the present multicenter study, we used structural magnetic resonance imaging (MRI) to compare 103 children and adolescents with TS to a well-matched group of 103 children without tics. We applied voxel-based morphometry methods to test gray matter (GM) and white matter (WM) volume differences between diagnostic groups, accounting for MRI scanner and sequence, age, sex and total GM+WM volume. The TS group demonstrated lower WM volume bilaterally in orbital and medial prefrontal cortex, and greater GM volume in posterior thalamus, hypothalamus and midbrain. These results demonstrate evidence for abnormal brain structure in children and youth with TS, consistent with and extending previous findings, and they point to new target regions and avenues of study in TS. For example, as orbital cortex is reciprocally connected with hypothalamus, structural abnormalities in these regions may relate to abnormal decision making, reinforcement learning or somatic processing in TS.
[Mh] Termos MeSH primário: Encéfalo/patologia
Síndrome de Tourette/patologia
[Mh] Termos MeSH secundário: Adolescente
Encéfalo/citologia
Encéfalo/diagnóstico por imagem
Estudos de Casos e Controles
Criança
Feminino
Substância Cinzenta/diagnóstico por imagem
Substância Cinzenta/patologia
Seres Humanos
Hipotálamo/patologia
Processamento de Imagem Assistida por Computador/métodos
Imagem por Ressonância Magnética/métodos
Masculino
Tamanho do Órgão/fisiologia
Córtex Pré-Frontal/patologia
Substância Branca/diagnóstico por imagem
Substância Branca/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180124
[Lr] Data última revisão:
180124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1038/mp.2016.194


  8 / 1771 MEDLINE  
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[PMID]:29244916
[Au] Autor:Sergeeva SP; Shishkina LV; Litvitskiy PF; Breslavich ID; Vinogradov EV
[Ti] Título:Structure changes of human brain gray matter neurons and astrocytes in acute local ischemic injury.
[So] Source:Patol Fiziol Eksp Ter;60(4):4-8, 2016 Oct-Dec.
[Is] ISSN:0031-2991
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Ab] Resumo:The purpose to identify key morphological features of the Astrocytes and Neurons in the acute local cerebral ischemia human cortex. Subjects and Methods: Left middle cerebral artery ischemic stroke died persons (n = 9) brain tissue samples from 3 zones: 1st - contiguous to the tissue necrotic damage site zone, 2nd - 5-10 cm distant from the previous one, 3rd - the damage site symmetrical zone of the contralateral hemisphere. For GFAP, MAP-2, NSE, p53 detection indirect immunoperoxidase immunohistochemical staining method has been used. Also, the samples were Nissl and Hematoxylin-Eosin stained. Results: The most pronounced changes in the quantity and morphological structure of astrocytes and neurons are found in directly adjacent to the necrotic core region of theleft middle cerebral artery ischemic stroke brain. This indicates the prevalence of the inflammation processes around the area of nerve tissueischemic destruction. Morphological changes of neurons and astrocytes, apoptosis, enhanced neuron-astrocyte interaction found in the area bordering on necrotic core (5-10 cm from it), as well as ischemic hearth symmetrical sites of the contralateral hemisphere. This interaction is essential for the neuroplasticityrealization in the local ischemic brain injury. Conclusion: The results obtained were shown the nerve tissue morphological characteristics changes occur in local cerebral cortex ischemic injury not only in the lesion, but also in the contralateral hemisphere. These changes are probably related to the implementation of neuroplasticity.
[Mh] Termos MeSH primário: Astrócitos/patologia
Isquemia Encefálica/patologia
Córtex Cerebral/patologia
Substância Cinzenta/patologia
Neurônios/patologia
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180118
[Lr] Data última revisão:
180118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171216
[St] Status:MEDLINE


  9 / 1771 MEDLINE  
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[PMID]:27776262
[Au] Autor:Sterling NW; Du G; Lewis MM; Swavely S; Kong L; Styner M; Huang X
[Ad] Endereço:Department of Neurology, Pennsylvania State University-Milton S. Hershey Medical Center, Hershey, PA, USA.
[Ti] Título:Cortical gray and subcortical white matter associations in Parkinson's disease.
[So] Source:Neurobiol Aging;49:100-108, 2017 Jan.
[Is] ISSN:1558-1497
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cortical atrophy has been documented in both Parkinson's disease (PD) and healthy aging, but its relationship to changes in subcortical white matter is unknown. This was investigated by obtaining T1- and diffusion-weighted images from 76 PD and 70 controls at baseline and 18 and 36 months, from which cortical volumes and underlying subcortical white matter axial diffusivity (AD), radial diffusivity (RD), and fractional anisotropy (FA) were determined. Twelve of 69 cortical subregions had significant group differences, and for these, underlying subcortical white matter was explored. At baseline, higher cortical volumes were significantly correlated with lower underlying subcortical white matter AD, RD, and higher FA (ps ≤ 0.017) in PD. Longitudinally, higher rates of cortical atrophy in PD were associated with increased rates of change in AD RD, and FA values (ps ≤ 0.0013) in 2 subregions explored. The significant gray-white matter associations were not found in controls. Thus, unlike healthy aging, cortical atrophy and subcortical white matter changes may not be independent events in PD.
[Mh] Termos MeSH primário: Córtex Cerebral/patologia
Substância Cinzenta/patologia
Doença de Parkinson/patologia
Substância Branca/patologia
[Mh] Termos MeSH secundário: Idoso
Anisotropia
Atrofia
Córtex Cerebral/diagnóstico por imagem
Imagem de Difusão por Ressonância Magnética
Imagem de Tensor de Difusão
Feminino
Substância Cinzenta/diagnóstico por imagem
Seres Humanos
Masculino
Meia-Idade
Bainha de Mielina
Neuroimagem
Doença de Parkinson/diagnóstico por imagem
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1711
[Cu] Atualização por classe:180112
[Lr] Data última revisão:
180112
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161025
[St] Status:MEDLINE


  10 / 1771 MEDLINE  
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[PMID]:27770743
[Au] Autor:Wu H; Sun H; Wang C; Yu L; Li Y; Peng H; Lu X; Hu Q; Ning Y; Jiang T; Xu J; Wang J
[Ad] Endereço:Key Laboratory for Neuroinformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China; The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, 510370, Chin
[Ti] Título:Abnormalities in the structural covariance of emotion regulation networks in major depressive disorder.
[So] Source:J Psychiatr Res;84:237-242, 2017 01.
[Is] ISSN:1879-1379
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Major depressive disorder (MDD) is a common psychiatric disorder that is characterized by cognitive deficits and affective symptoms. To date, an increasing number of neuroimaging studies have focused on emotion regulation and have consistently shown that emotion dysregulation is one of the central features and underlying mechanisms of MDD. Although gray matter morphological abnormalities in regions within emotion regulation networks have been identified in MDD, the interactions and relationships between these gray matter structures remain largely unknown. Thus, in this study, we adopted a structural covariance method based on gray matter volume to investigate the brain morphological abnormalities within the emotion regulation networks in a large cohort of 65 MDD patients and 65 age- and gender-matched healthy controls. A permutation test with p < 0.05 was used to identify the significant changes in covariance connectivity strengths between MDD patients and healthy controls. The structural covariance analysis revealed an increased correlation strength of gray matter volume between the left angular gyrus and the left amygdala and between the right angular gyrus and the right amygdala, as well as a decreased correlation strength of the gray matter volume between the right angular gyrus and the posterior cingulate cortex in MDD. Our findings support the notion that emotion dysregulation is an underlying mechanism of MDD by revealing disrupted structural covariance patterns in the emotion regulation network.
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Transtorno Depressivo Maior/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Estudos de Coortes
Transtorno Depressivo Maior/tratamento farmacológico
Emoções
Feminino
Substância Cinzenta/diagnóstico por imagem
Seres Humanos
Processamento de Imagem Assistida por Computador
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Vias Neurais/diagnóstico por imagem
Tamanho do Órgão
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180111
[Lr] Data última revisão:
180111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161023
[St] Status:MEDLINE



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