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Pesquisa : A08.186.211.204 [Categoria DeCS]
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[PMID]:29237528
[Au] Autor:Feng EC; Jiang L
[Ad] Endereço:School of Biological Science & Medical Engineering, Southeast University, Nanjing 210018, China. jiangli77777@126.com.
[Ti] Título:[Effect of leptin on long-term spatial memory of rats with white matter damage in developing brain].
[So] Source:Zhongguo Dang Dai Er Ke Za Zhi;19(12):1267-1271, 2017 Dec.
[Is] ISSN:1008-8830
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the neuroprotective effect of leptin by observing its effect on spatial memory of rats with white matter damage in developing brain. METHODS: A total of 80 neonatal rats were randomly divided into 3 groups: sham-operation (n=27), model (n=27) and leptin intervention (n=27). The rats in the model and leptin intervention groups were used to prepare a model of white matter damage in developing brain, and the rats in the leptin intervention group were given leptin (100 µg/kg) diluted with normal saline immediately after modelling for 4 consecutive days. The survival rate of the rats was observed and the change in body weight was monitored. When the rats reached the age of 21 days, the Morris water maze test was used to evaluate spatial memory. RESULTS: There was no significant difference in the survival rate of rats between the three groups (P>0.05). Within 10 days after birth, the leptin intervention group had similar body weight as the sham-operation group and significantly lower body weight than the model group (P<0.05); more than 10 days after birth, the leptin intervention group had rapid growth with higher body weight than the model and sham-operation groups (P>0.05). The results of place navigation showed that from the second day of experiment, there was a significant difference in the latency period between the three groups (P<0.05); from the fourth day of experiment, the leptin intervention group had a similar latency period as the sham-operation and a significantly shorter latency period than the model group (P<0.05). The results of space search experiment showed that compared with the sham-operation group, the model group had a significant reduction in the number of platform crossings and a significantly longer latency period (P<0.05); compared with the model group, the leptin intervention group had a significantly increased number of platform crossings and a significantly shortened latency period (P<0.05), while there was no significant difference between the leptin intervention and sham-operation groups. CONCLUSIONS: Leptin can alleviate spatial memory impairment of rats with white matter damage in developing brain. It thus exerts a neuroprotective effect, and is worthy of further research.
[Mh] Termos MeSH primário: Leptina/farmacologia
Aprendizagem em Labirinto/efeitos dos fármacos
Fármacos Neuroprotetores/farmacologia
Memória Espacial/efeitos dos fármacos
Substância Branca/patologia
[Mh] Termos MeSH secundário: Animais
Feminino
Gravidez
Ratos
Ratos Sprague-Dawley
Tempo de Reação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Leptin); 0 (Neuroprotective Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180306
[Lr] Data última revisão:
180306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171215
[St] Status:MEDLINE


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[PMID]:28460824
[Au] Autor:Connor M; Karunamuni R; McDonald C; Seibert T; White N; Moiseenko V; Bartsch H; Farid N; Kuperman J; Krishnan A; Dale A; Hattangadi-Gluth JA
[Ad] Endereço:Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California, United States.
[Ti] Título:Regional susceptibility to dose-dependent white matter damage after brain radiotherapy.
[So] Source:Radiother Oncol;123(2):209-217, 2017 05.
[Is] ISSN:1879-0887
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Regional differences in sensitivity to white matter damage after brain radiotherapy (RT) are not well-described. We characterized the spatial heterogeneity of dose-response across white matter tracts using diffusion tensor imaging (DTI). MATERIALS AND METHODS: Forty-nine patients with primary brain tumors underwent MRI with DTI before and 9-12months after partial-brain RT. Maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) were generated. Atlas-based white matter tracts were identified. A secondary analysis using skeletonized tracts was also performed. Linear mixed-model analysis of the relationship between mean and max dose and percent change in DTI metrics was performed. RESULTS: Tracts with the strongest correlation of FA change with mean dose were the fornix (-0.46 percent/Gy), cingulum bundle (-0.44 percent/Gy), and body of corpus callosum (-0.23 percent/Gy), p<.001. These tracts also showed dose-sensitive changes in MD and RD. In the skeletonized analysis, the fornix and cingulum bundle remained highly dose-sensitive. Maximum and mean dose were similarly predictive of DTI change. CONCLUSIONS: The corpus callosum, cingulum bundle, and fornix show the most prominent dose-dependent changes following RT. Future studies examining correlation with cognitive functioning and potential avoidance of critical white matter regions are warranted.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/radioterapia
Substância Branca/efeitos da radiação
[Mh] Termos MeSH secundário: Adulto
Neoplasias Encefálicas/diagnóstico por imagem
Imagem de Tensor de Difusão
Relação Dose-Resposta à Radiação
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Substância Branca/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170503
[St] Status:MEDLINE


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[PMID]:27776747
[Au] Autor:Connor M; Karunamuni R; McDonald C; White N; Pettersson N; Moiseenko V; Seibert T; Marshall D; Cervino L; Bartsch H; Kuperman J; Murzin V; Krishnan A; Farid N; Dale A; Hattangadi-Gluth J
[Ad] Endereço:Department of Radiation Medicine and Applied Sciences, University of California San Diego, United States.
[Ti] Título:Dose-dependent white matter damage after brain radiotherapy.
[So] Source:Radiother Oncol;121(2):209-216, 2016 11.
[Is] ISSN:1879-0887
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Brain radiotherapy is limited in part by damage to white matter, contributing to neurocognitive decline. We utilized diffusion tensor imaging (DTI) with multiple b-values (diffusion weightings) to model the dose-dependency and time course of radiation effects on white matter. MATERIALS AND METHODS: Fifteen patients with high-grade gliomas treated with radiotherapy and chemotherapy underwent MRI with DTI prior to radiotherapy, and after months 1, 4-6, and 9-11. Diffusion tensors were calculated using three weightings (high, standard, and low b-values) and maps of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λ ), and radial diffusivity (λ ) were generated. The region of interest was all white matter. RESULTS: MD, λ , and λ increased significantly with time and dose, with corresponding decrease in FA. Greater changes were seen at lower b-values, except for FA. Time-dose interactions were highly significant at 4-6months and beyond (p<.001), and the difference in dose response between high and low b-values reached statistical significance at 9-11months for MD, λ , and λ (p<.001, p<.001, p=.005 respectively) as well as at 4-6months for λ (p=.04). CONCLUSIONS: We detected dose-dependent changes across all doses, even <10Gy. Greater changes were observed at low b-values, suggesting prominent extracellular changes possibly due to vascular permeability and neuroinflammation.
[Mh] Termos MeSH primário: Neoplasias Encefálicas/radioterapia
Irradiação Craniana/efeitos adversos
Glioma/radioterapia
Substância Branca/efeitos da radiação
[Mh] Termos MeSH secundário: Adulto
Idoso
Idoso de 80 Anos ou mais
Neoplasias Encefálicas/diagnóstico por imagem
Imagem de Tensor de Difusão
Relação Dose-Resposta à Radiação
Feminino
Glioma/diagnóstico por imagem
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1709
[Cu] Atualização por classe:180307
[Lr] Data última revisão:
180307
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE


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[PMID]:28455324
[Au] Autor:Kulick ER; Wellenius GA; Kaufman JD; DeRosa JT; Kinney PL; Cheung YK; Wright CB; Sacco RL; Elkind MS
[Ad] Endereço:From the Department of Epidemiology, Mailman School of Public Health (E.R.K., M.S.E.), Department of Neurology, College of Physicians and Surgeons (E.R.K., J.T.D., M.S.E.), and Department of Biostatistics, Mailman School of Public Health (Y.K.C.), Columbia University, New York, NY; Department of Epi
[Ti] Título:Long-Term Exposure to Ambient Air Pollution and Subclinical Cerebrovascular Disease in NOMAS (the Northern Manhattan Study).
[So] Source:Stroke;48(7):1966-1968, 2017 07.
[Is] ISSN:1524-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Long-term exposure to ambient air pollution is associated with higher risk of cardiovascular disease and stroke. We hypothesized that long-term exposure to air pollution would be associated with magnetic resonance imaging markers of subclinical cerebrovascular disease. METHODS: Participants were 1075 stroke-free individuals aged ≥50 years drawn from the magnetic resonance imaging subcohort of the Northern Manhattan Study who had lived at the same residence for at least 2 years before magnetic resonance imaging. Cross-sectional associations between ambient air pollution and subclinical cerebrovascular disease were analyzed. RESULTS: We found an association between distance to roadway, a proxy for residential exposure to traffic pollution, and white matter hyperintensity volume; however, after adjusting for risk factors, this relationship was no longer present. All other associations between pollutant measures and white matter hyperintensity volume were null. There was no clear association between exposure to air pollutants and subclinical brain infarcts or total cerebral brain volume. CONCLUSIONS: We found no evidence that long-term exposure to ambient air pollution is independently associated with subclinical cerebrovascular disease in an urban population-based cohort.
[Mh] Termos MeSH primário: Poluição do Ar/efeitos adversos
Transtornos Cerebrovasculares/induzido quimicamente
Transtornos Cerebrovasculares/diagnóstico por imagem
Exposição Ambiental/efeitos adversos
Substância Branca/diagnóstico por imagem
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Estudos Transversais
Feminino
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Cidade de Nova Iorque
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1707
[Cu] Atualização por classe:180305
[Lr] Data última revisão:
180305
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1161/STROKEAHA.117.016672


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[PMID]:28450434
[Au] Autor:Li X; Gao J; Wang M; Zheng J; Li Y; Hui ES; Wan M; Yang J
[Ad] Endereço:From the Department of Radiology (X.L., J.G., M. Wang, Y.L., J.Y.).
[Ti] Título:Characterization of Extensive Microstructural Variations Associated with Punctate White Matter Lesions in Preterm Neonates.
[So] Source:AJNR Am J Neuroradiol;38(6):1228-1234, 2017 Jun.
[Is] ISSN:1936-959X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND AND PURPOSE: Punctate white matter lesions are common in preterm neonates. Neurodevelopmental outcomes of the neonates are related to the degree of extension. This study aimed to characterize the extent of microstructural variations for different punctate white matter lesion grades. MATERIALS AND METHODS: Preterm neonates with punctate white matter lesions were divided into 3 grades (from mild to severe: grades I-III). DTI-derived fractional anisotropy, axial diffusivity, and radial diffusivity between patients with punctate white matter lesions and controls were compared with Tract-Based Spatial Statistics and tract-quantification methods. RESULTS: Thirty-three preterm neonates with punctate white matter lesions and 33 matched controls were enrolled. There were 15, 9, and 9 patients, respectively, in grades I, II, and III. Punctate white matter lesions were mainly located in white matter adjacent to the lateral ventricles, especially regions lateral to the trigone, posterior horns, and centrum semiovale and/or corona radiata. Extensive microstructural changes were observed in neonates with grade III punctate white matter lesions, while no significant changes in DTI metrics were found for grades I and II. A pattern of increased axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy was found in regions adjacent to punctate white matter lesion sites seen on T1WI and T2WI. Unchanged axial diffusivity, increased radial diffusivity, and reduced/unchanged fractional anisotropy were observed in regions distant from punctate white matter lesion sites. CONCLUSIONS: White matter microstructural variations were different across punctate white matter lesion grades. Extensive change patterns varied according to the distance to the lesion sites in neonates with severe punctate white matter lesions. These findings may help in determining the outcomes of punctate white matter lesions and selecting treatment strategies.
[Mh] Termos MeSH primário: Recém-Nascido Prematuro
Substância Branca/ultraestrutura
[Mh] Termos MeSH secundário: Anisotropia
Ventrículos Cerebrais/diagnóstico por imagem
Ventrículos Cerebrais/patologia
Ventrículos Cerebrais/ultraestrutura
Corpo Caloso/diagnóstico por imagem
Corpo Caloso/patologia
Corpo Caloso/ultraestrutura
Estudos Transversais
Imagem de Tensor de Difusão
Feminino
Seres Humanos
Recém-Nascido
Masculino
Tratos Piramidais/diagnóstico por imagem
Tratos Piramidais/patologia
Tratos Piramidais/ultraestrutura
Substância Branca/diagnóstico por imagem
Substância Branca/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE
[do] DOI:10.3174/ajnr.A5226


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[PMID]:29390252
[Au] Autor:Li SS; Zheng J; Mei B; Wang HY; Zheng M; Zheng K
[Ad] Endereço:Department of Geriatrics.
[Ti] Título:Correlation study of Framingham risk score and vascular dementia: An observational study.
[So] Source:Medicine (Baltimore);96(50):e8387, 2017 Dec.
[Is] ISSN:1536-5964
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Vascular dementia (VaD) is one of the most common forms of dementia, and second only to Alzheimer's disease. The purpose of this study was to evaluate the potential diagnostic value of Framingham risk score (FRS) in VaD by investigating the relationship among cardiovascular risks, FRS, and VaD.Data were collected from patients (n = 130) at Tongji Hospital in Wuhan, China. They were divided into 2 groups, including the control group (n = 70) and the VaD group (n = 60). Statistical methods including t-test, logistic regression model, multiple linear regression model, and receiver-operating characteristic (ROC) curve were adopted for the assessment.A significant difference (all P < .05) was observed in systolic blood pressure (SBP), diastolic blood pressure (DBP), pulse pressure, total cholesterol (TC), homosysteine (HCY), glycosylated hemoglobin A1c (HbA1c), FRS, and cerebral white matter lesions (WMLs) between the 2 groups, even after adjusting for age (both P < .05). Age [odds ratio (OR) = 1.20; P = .002], FRS (OR = 1.55; P = .006), and WMLs (OR = 10.17; P = .011) were independent prognostic factors for VaD. The area under the ROC curve (AUC) of FRS for VaD diagnosis prediction was 0.830 (95% confidence interval, 95% CI: 0.730∼ 0.929). There was a significant difference in the AUC between WMLs and WMLs combined with FRS (0.788 (95% CI: 0.667 ∼ 0.880) versus 0.863 (95% CI: 0.754 ∼ 0.936, P = .049). Age, HbA1c, and FRS were negatively correlated with the mini-mental state examination (MMSE) scores (all P < .05) in the VaD group. Moreover, multiple stepwise linear regression analysis showed that the age and FRS were independent predictors of MMSE scores.FRS has a moderate predictive value for the VaD diagnosis, and also increases the risk of cognitive decline.
[Mh] Termos MeSH primário: Demência Vascular/diagnóstico
Medição de Risco/métodos
[Mh] Termos MeSH secundário: Fatores Etários
Idoso
Idoso de 80 Anos ou mais
Pressão Sanguínea/fisiologia
Estudos de Casos e Controles
Colesterol/sangue
Disfunção Cognitiva/fisiopatologia
Feminino
Hemoglobina A Glicada/análise
Homocisteína/sangue
Seres Humanos
Modelos Lineares
Imagem por Ressonância Magnética
Masculino
Testes de Estado Mental e Demência
Meia-Idade
Prognóstico
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Glycated Hemoglobin A); 0 (hemoglobin A1c protein, human); 0LVT1QZ0BA (Homocysteine); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:180203
[St] Status:MEDLINE
[do] DOI:10.1097/MD.0000000000008387


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[PMID]:28451635
[Au] Autor:Moyon S; Ma D; Huynh JL; Coutts DJC; Zhao C; Casaccia P; Franklin RJM
[Ad] Endereço:Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
[Ti] Título:Efficient Remyelination Requires DNA Methylation.
[So] Source:eNeuro;4(2), 2017 Mar-Apr.
[Is] ISSN:2373-2822
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Oligodendrocyte progenitor cells (OPCs) are the principal source of new myelin in the central nervous system. A better understanding of how they mature into myelin-forming cells is of high relevance for remyelination. It has recently been demonstrated that during developmental myelination, the DNA methyltransferase 1 (DNMT1), but not DNMT3A, is critical for regulating proliferation and differentiation of OPCs into myelinating oligodendrocytes (OLs). However, it remains to be determined whether DNA methylation is also critical for the differentiation of adult OPCs during remyelination. After lysolecithin-induced demyelination in the ventrolateral spinal cord white matter of adult mice of either sex, we detected increased levels of DNA methylation and higher expression levels of the DNA methyltransferase DNMT3A and lower levels of DNMT1 in differentiating adult OLs. To functionally assess the role of DNMT1 and DNMT3 in adult OPCs, we used mice with inducible and lineage-specific ablation of and/or (i.e., , ). Upon lysolecithin injection in the spinal cord of these transgenic mice, we detected defective OPC differentiation and inefficient remyelination in the null and null mice, but not in the null mice. Taken together with previous results in the developing spinal cord, these data suggest an age-dependent role of distinct DNA methyltransferases in the oligodendrocyte lineage, with a dominant role for DNMT1 in neonatal OPCs and for DNMT3A in adult OPCs.
[Mh] Termos MeSH primário: DNA (Citosina-5-)-Metiltransferase 1/metabolismo
DNA (Citosina-5-)-Metiltransferases/metabolismo
Metilação de DNA
Células Precursoras de Oligodendrócitos/metabolismo
Remielinização
Medula Espinal/metabolismo
[Mh] Termos MeSH secundário: Animais
DNA (Citosina-5-)-Metiltransferase 1/genética
DNA (Citosina-5-)-Metiltransferases/genética
Doenças Desmielinizantes/induzido quimicamente
Doenças Desmielinizantes/metabolismo
Feminino
Lisofosfatidilcolinas/administração & dosagem
Masculino
Camundongos Endogâmicos C57BL
Camundongos Knockout
Células Precursoras de Oligodendrócitos/ultraestrutura
Substância Branca/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lysophosphatidylcholines); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferase 1); EC 2.1.1.37 (DNA (Cytosine-5-)-Methyltransferases); EC 2.1.1.37 (DNA methyltransferase 3A); EC 2.1.1.37 (Dnmt1 protein, mouse)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170429
[St] Status:MEDLINE


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[PMID]:28470928
[Au] Autor:Ganzola R; Nickson T; Bastin ME; Giles S; Macdonald A; Sussmann J; McIntosh AM; Whalley HC; Duchesne S
[Ad] Endereço:Institut universitaire en santé mentale de Québec, Québec City, Québec, Canada.
[Ti] Título:Longitudinal differences in white matter integrity in youth at high familial risk for bipolar disorder.
[So] Source:Bipolar Disord;19(3):158-167, 2017 May.
[Is] ISSN:1399-5618
[Cp] País de publicação:Denmark
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: Previous neuroimaging studies have reported abnormalities in white matter (WM) pathways in subjects at high familial risk of mood disorders. In the current study, we examined the trajectory of these abnormalities during the early stages of illness development using longitudinal diffusion tensor imaging (DTI) data. METHODS: Subjects (16-28 years old) were recruited in the Scottish Bipolar Family Study, a prospective longitudinal study that has examined individuals at familial risk of mood disorder on three occasions, 2 years apart. The current study concerns imaging data from the first and second assessments. We analysed DTI data for 43 controls and 69 high-risk individuals who were further subdivided into a group of 53 high-risk subjects who remained well (high-risk well) and 16 who met diagnostic criteria for major depressive disorder (high-risk MDD) at follow-up. Longitudinal differences in fractional anisotropy (FA) between groups based on diagnostic status were investigated using the tract-based spatial statistics technique (TBSS). RESULTS: We found a significant reduction in FA (P <.05) across widespread brain regions over 2 years in all three groups. The trajectory of FA reduction did not differ significantly between groups. CONCLUSIONS: These results suggest that there are similar trajectories of FA reductions for controls and high-risk young adults, despite high-risk individuals being at a disadvantaged starting point considering their reduced WM integrity detected at baseline in previous studies. Difference in WM integrity between high-risk individuals and controls could therefore occur in earlier childhood and be a necessary but not sufficient condition to develop future mood disorders.
[Mh] Termos MeSH primário: Transtorno Bipolar
Substância Branca/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Anisotropia
Transtorno Bipolar/diagnóstico
Transtorno Bipolar/epidemiologia
Transtorno Depressivo Maior/diagnóstico
Transtorno Depressivo Maior/epidemiologia
Imagem de Tensor de Difusão/métodos
Feminino
Seres Humanos
Estudos Longitudinais
Masculino
Anamnese/métodos
Neuroimagem/métodos
Estudos Prospectivos
Medição de Risco
Fatores de Risco
Escócia/epidemiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170505
[St] Status:MEDLINE
[do] DOI:10.1111/bdi.12489


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[PMID]:27778099
[Au] Autor:Fiorenzato E; Weis L; Seppi K; Onofrj M; Cortelli P; Zanigni S; Tonon C; Kaufmann H; Shepherd TM; Poewe W; Krismer F; Wenning G; Antonini A; Biundo R; Movement Disorders Society MSA (MODIMSA) Neuropsychology and Imaging Study Groups
[Ad] Endereço:Parkinson Disease and Movement Disorders Unit, IRCCS San Camillo Hospital Foundation, via Alberoni, 70, 30126, Venice-Lido, Italy. eleonora.fiorenzato@gmail.com.
[Ti] Título:Brain structural profile of multiple system atrophy patients with cognitive impairment.
[So] Source:J Neural Transm (Vienna);124(3):293-302, 2017 Mar.
[Is] ISSN:1435-1463
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Current consensus diagnostic criteria for multiple system atrophy (MSA) consider dementia a non-supporting feature, although cognitive impairment and even frank dementia are reported in clinical practice. Mini-Mental State Examination (MMSE) is a commonly used global cognitive scale, and in a previous study, we established an MSA-specific screening cut-off score <27 to identify cognitive impairment. Finally, MSA neuroimaging findings suggest the presence of structural alterations in patients with cognitive deficits, although the extent of the anatomical changes is unclear. The aim of our multicenter study is to better characterize anatomical changes associated with cognitive impairment in MSA and to further investigate cortical and subcortical structural differences versus healthy controls (HC). We examined retrospectively 72 probable MSA patients [50 with normal cognition (MSA-NC) and 22 cognitively impaired (MSA-CI) based on MMSE <27] and compared them to 36 HC using gray- and white-matter voxel-based morphometry and fully automated subcortical segmentation. Compared to HC, MSA patients showed widespread cortical (bilateral frontal, occipito-temporal, and parietal areas), subcortical, and white-matter alterations. However, MSA-CI showed only focal volume reduction in the left dorsolateral prefrontal cortex compared with MSA-NC. These results suggest only a marginal contribution of cortical pathology to cognitive deficits. We believe that cognitive dysfunction is driven by focal fronto-striatal degeneration in line with the concept of "subcortical cognitive impairment".
[Mh] Termos MeSH primário: Encéfalo/diagnóstico por imagem
Disfunção Cognitiva/complicações
Disfunção Cognitiva/diagnóstico por imagem
Atrofia de Múltiplos Sistemas/complicações
Atrofia de Múltiplos Sistemas/diagnóstico por imagem
[Mh] Termos MeSH secundário: Feminino
Substância Cinzenta/diagnóstico por imagem
Seres Humanos
Imagem Tridimensional
Imagem por Ressonância Magnética
Masculino
Testes de Estado Mental e Demência
Meia-Idade
Atrofia de Múltiplos Sistemas/psicologia
Neuroimagem
Tamanho do Órgão
Reconhecimento Automatizado de Padrão
Estudos Retrospectivos
Substância Branca/diagnóstico por imagem
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180220
[Lr] Data última revisão:
180220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161026
[St] Status:MEDLINE
[do] DOI:10.1007/s00702-016-1636-0


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[PMID]:28465080
[Au] Autor:Komatsu J; Sakai K; Nakada M; Iwasa K; Yamada M
[Ad] Endereço:Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa 920-8640, Japan. Electronic address: kjunji@med.kanazawa-u.ac.jp.
[Ti] Título:Long spinal cord lesions in a patient with pathologically proven multiple sclerosis.
[So] Source:J Clin Neurosci;42:106-108, 2017 Aug.
[Is] ISSN:1532-2653
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system. We report the case of a 50-year-old man who presented with progressive gait ataxia. Brain magnetic resonance imaging (MRI) on fluid-attenuated inversion recovery revealed a hyperintense lesion in the right temporal white matter. The spinal cord showed a long hyperintense lesion between the vertebral levels C6 and L1 on T2-weighted MRI. Biopsied tissues from the brain lesion demonstrated features of inflammatory demyelination with preservation of astrocytes, consistent with typical MS. This is the first reported case of pathologically proven MS with longitudinally extensive spinal cord lesions.
[Mh] Termos MeSH primário: Esclerose Múltipla/patologia
Medula Espinal/patologia
[Mh] Termos MeSH secundário: Vértebras Cervicais/patologia
Seres Humanos
Vértebras Lombares/patologia
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Lobo Temporal/patologia
Substância Branca/patologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180219
[Lr] Data última revisão:
180219
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE



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