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  1 / 1951 MEDLINE  
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[PMID]:28434960
[Au] Autor:Das KK; Gosal JS; Singh S; Mehrotra A; Jaiswal A; Jaiswal S; Kumar R
[Ad] Endereço:Department of Neurosurgery, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. Electronic address: drkuntalkantidas@gmail.com.
[Ti] Título:Solitary Cysticercal Cyst Inside the Blake's Pouch Remnant of Mega Cisterna Magna with Associated Aqueductal Stenosis: Clinical and Management Implications.
[So] Source:World Neurosurg;102:693.e1-693.e5, 2017 Jun.
[Is] ISSN:1878-8769
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intraventricular and subarachnoid forms represent the relatively complex, albeit uncommon, manifestations of central nervous system involvement by cysticercal cysts. Cysticercal encystation inside the Blake's pouch remnant of mega cisterna magna (MCM) remains an extremely rare clinical scenario that, to the best of our knowledge, has not been reported previously. CASE PRESENTATION: A 12-year-old boy presented with acute worsening and subsequent spontaneous resolution of his compensated hydrocephalus. Neuroimaging revealed features consistent with a MCM with septum inside, indicating remnants of the embryologic fourth ventricular diverticulum, the Blake's pouch. It also revealed a free-floating intact cysticercal cyst inside the MCM limited by the septum with aqueductal stenosis. The spontaneous clinicoradiologic resolution of hydrocephalus raised the possibility of ball valve obstruction of the cerebrospinal fluid outflow, i.e., Bruns syndrome. We successfully treated this patient with endoscopic extraction of the viable cysticercal cyst through a suboccipital burrhole. CONCLUSIONS: The clinical scenario presented here has not been described previously. Endoscopic cyst removal in such a situation is an effective and low-risk procedure that obviates the further need for antihelminthic medications.
[Mh] Termos MeSH primário: Cistos Ósseos/cirurgia
Infecções Parasitárias do Sistema Nervoso Central/cirurgia
Cisterna Magna/cirurgia
Neurocisticercose/cirurgia
[Mh] Termos MeSH secundário: Animais
Cistos Ósseos/patologia
Infecções Parasitárias do Sistema Nervoso Central/patologia
Criança
Constrição Patológica/patologia
Constrição Patológica/cirurgia
Seres Humanos
Masculino
Neuroendoscopia/métodos
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE


  2 / 1951 MEDLINE  
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[PMID]:28279513
[Au] Autor:Kohta M; Sasayama T; Nakai T; Taniguchi M; Nagashima H; Tanaka K; Mizukawa K; Itoh T; Kohmura E
[Ad] Endereço:Department of Neurosurgery, Kobe University Graduate School of Medicine, Kobe, Japan.
[Ti] Título:Cisterna magna meningiomas without dural attachment: Report of two cases.
[So] Source:Neurol Neurochir Pol;51(3):247-251, 2017 May - Jun.
[Is] ISSN:0028-3843
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:Meningiomas within the cisterna magna without dural attachment are extremely rare. To the best of our knowledge, only three cases of meningiomas within the cisterna magna have been reported in the literature. The authors present two cases of patient with the cisterna magna meningioma without dural attachment. (Case 1) A 36-year-old female presented with a 10-month history of numbness in the left hand. Magnetic resonance imaging (MRI) disclosed the presence of a contrast-enhanced tumor in the posterior fossa. A suboccipital craniectomy was performed, and the tumor located within the cisterna magna with no attachment to the dura. Diagnosis is made as clear cell meningioma. The postoperative course was uneventful, and a recurrence has not been observed for three years. (Case 2) A 58-year-old man presented with a well-circumscribed mass in the posterior fossa. At surgery, the tumor located within the cisterna magna with a connection to the right tenia. The tumor was totally removed without neurological deficits. At a 7-year follow-up, no evidence of a recurrence was observed. It is quite difficult to preoperatively diagnose as a cisterna magna meningioma without dural attachment. However, complete removal of the tumor should be achieved.
[Mh] Termos MeSH primário: Cisterna Magna/diagnóstico por imagem
Dura-Máter/diagnóstico por imagem
Neoplasias Meníngeas/diagnóstico por imagem
Meningioma/diagnóstico por imagem
[Mh] Termos MeSH secundário: Adulto
Cisterna Magna/patologia
Cisterna Magna/cirurgia
Diagnóstico Diferencial
Dura-Máter/patologia
Dura-Máter/cirurgia
Feminino
Seguimentos
Seres Humanos
Aumento da Imagem
Imagem por Ressonância Magnética
Masculino
Neoplasias Meníngeas/patologia
Neoplasias Meníngeas/cirurgia
Meningioma/patologia
Meningioma/cirurgia
Meia-Idade
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE


  3 / 1951 MEDLINE  
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[PMID]:28052210
[Au] Autor:Mowafy YN; Wahba NA; Sharaf AA
[Ti] Título:Joubert Plus Syndrome with Self-Mutilation: A Case report.
[So] Source:J Clin Pediatr Dent;41(1):66-69, 2017.
[Is] ISSN:1053-4628
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Joubert syndrome is a very rare condition with dismal prognosis. It is characterized by several abnormalities including molar tooth sign on MRI. When coupled with mega cisterna magna- a feature of the Dandy Walker syndrome- it is categorized as Joubert plus syndrome. CASE REPORT: A 16 month old male child with Joubert syndrome was referred to the Pediatric Dentistry Department Clinic, Faculty of Dentistry Alexandria University, complaining of severe tongue and lower lip injury due to self-mutilation. He required multiple teeth extractions under general anesthesia to prevent further tongue and lip mutilation. CONCLUSION: Joubert plus syndrome is a very rare occurring condition. Because self-mutilation is sometimes fatal, a treatment plan tailored to each patient's need is mandatory. A multidisciplinary approach is recommended.
[Mh] Termos MeSH primário: Cerebelo/anormalidades
Anormalidades do Olho/complicações
Doenças Renais Císticas/complicações
Lábio/lesões
Retina/anormalidades
Automutilação/etiologia
Língua/lesões
[Mh] Termos MeSH secundário: Anormalidades Múltiplas
Cisterna Magna/anormalidades
Seres Humanos
Lactente
Masculino
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170307
[Lr] Data última revisão:
170307
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:170105
[St] Status:MEDLINE
[do] DOI:10.17796/1053-4628-41.1.66


  4 / 1951 MEDLINE  
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[PMID]:27977023
[Au] Autor:Ineichen BV; Schnell L; Gullo M; Kaiser J; Schneider MP; Mosberger AC; Good N; Linnebank M; Schwab ME
[Ad] Endereço:Brain Research Institute, University of Zurich, Zurich, Switzerland.
[Ti] Título:Direct, long-term intrathecal application of therapeutics to the rodent CNS.
[So] Source:Nat Protoc;12(1):104-131, 2017 Jan.
[Is] ISSN:1750-2799
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Systemic application of therapeutics to the CNS tissue often results in subtherapeutic drug levels, because of restricted and selective penetration through the blood-brain barrier (BBB). Here, we give a detailed description of a standardized technique for intrathecal drug delivery in rodents, analogous to the technique used in humans. The intrathecal drug delivery method bypasses the BBB and thereby offers key advantages over oral or intravenous administration, such as maximized local drug doses with minimal systemic side effects. We describe how to deliver antibodies or drugs over several days or weeks from a s.c. minipump and a fine catheter inserted into the subdural space over the spinal cord (20 min operative time) or into the cisterna magna (10 min operative time). Drug levels can be sampled by quick and minimally invasive cerebrospinal fluid (CSF) collection from the cisterna magna (5 min procedure time). These techniques enable targeted application of any compound to the CNS for therapeutic studies in a wide range of CNS disease rodent models. Basic surgery skills are helpful for carrying out the procedures described in this protocol.
[Mh] Termos MeSH primário: Cisterna Magna
Injeções Espinhais/métodos
Preparações Farmacêuticas/administração & dosagem
Espaço Subdural
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Cateteres
Cisterna Magna/metabolismo
Feminino
Injeções Espinhais/instrumentação
Masculino
Preparações Farmacêuticas/metabolismo
Ratos
Espaço Subdural/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Pharmaceutical Preparations)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170529
[Lr] Data última revisão:
170529
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161216
[St] Status:MEDLINE
[do] DOI:10.1038/nprot.2016.151


  5 / 1951 MEDLINE  
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[PMID]:27885100
[Au] Autor:Zhang Y; Fan F; Zeng G; Zhou L; Zhang Y; Zhang J; Jiao H; Zhang T; Su D; Yang C; Wang X; Xiao K; Li H; Zhong Z
[Ad] Endereço:1 Laboratory of Nonhuman Primate Disease Modeling Research, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
[Ti] Título:Temporal analysis of blood-brain barrier disruption and cerebrospinal fluid matrix metalloproteinases in rhesus monkeys subjected to transient ischemic stroke.
[So] Source:J Cereb Blood Flow Metab;37(8):2963-2974, 2017 Aug.
[Is] ISSN:1559-7016
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Blood-brain barrier (BBB) disruption plays an important role in pathophysiological progress of ischemic stroke. However, our knowledge of the dynamic change of BBB permeability and its mechanism remains limited. In the current study, we used a non-human primate (NHP) MCAO model and a serial CSF sampling method that allowed us to determine the dynamic change of BBB permeability by calculating the CSF/serum albumin ratio (AR). We showed that AR increased rapidly and significantly after ischemia, and the fold increase of AR is highly correlated with the infarction size during the subacute phase. Moreover, we determined the temporal change of MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, MMP-13, TIMP-1, and TIMP-2 in CSF and serum. Each MMP and TIMP showed different change patterns when comparing their values in CSF and serum. Based on the longitudinal dataset, we showed that the fold increase of MMP-9 in serum and CSF are both correlated to infarction size. Among the measured MMPs and TIMPs, only MMP-2, MMP-13, and TIMP-2 in CSF correlated with AR to some extent. Our data suggest there is no single MMP or TIMP fully responsible for BBB breakdown, which is regulated by a much more complicated signal network and further investigations of the mechanisms are needed.
[Mh] Termos MeSH primário: Barreira Hematoencefálica/fisiopatologia
Permeabilidade Capilar/fisiologia
Líquido Cefalorraquidiano/enzimologia
Ataque Isquêmico Transitório/fisiopatologia
Metaloproteinases da Matriz/metabolismo
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/fisiologia
Barreira Hematoencefálica/diagnóstico por imagem
Cisterna Magna/diagnóstico por imagem
Modelos Animais de Doenças
Ataque Isquêmico Transitório/sangue
Ataque Isquêmico Transitório/líquido cefalorraquidiano
Ataque Isquêmico Transitório/diagnóstico por imagem
Macaca mulatta
Imagem por Ressonância Magnética
Masculino
Metaloproteinases da Matriz/sangue
Albumina Sérica/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Serum Albumin); EC 3.4.24.- (Matrix Metalloproteinases)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161126
[St] Status:MEDLINE
[do] DOI:10.1177/0271678X16680221


  6 / 1951 MEDLINE  
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[PMID]:27306753
[Au] Autor:Bedussi B; van der Wel NN; de Vos J; van Veen H; Siebes M; VanBavel E; Bakker EN
[Ad] Endereço:1 Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, The Netherlands.
[Ti] Título:Paravascular channels, cisterns, and the subarachnoid space in the rat brain: A single compartment with preferential pathways.
[So] Source:J Cereb Blood Flow Metab;37(4):1374-1385, 2017 Apr.
[Is] ISSN:1559-7016
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Recent evidence suggests an extensive exchange of fluid and solutes between the subarachnoid space and the brain interstitium, involving preferential pathways along blood vessels. We studied the anatomical relations between brain vasculature, cerebrospinal fluid compartments, and paravascular spaces in male Wistar rats. A fluorescent tracer was infused into the cisterna magna, without affecting intracranial pressure. Tracer distribution was analyzed using a 3D imaging cryomicrotome, confocal microscopy, and correlative light and electron microscopy. We found a strong 3D colocalization of tracer with major arteries and veins in the subarachnoid space and large cisterns, attributed to relatively large subarachnoid space volumes around the vessels. Confocal imaging confirmed this colocalization and also revealed novel cisternal connections between the subarachnoid space and ventricles. Unlike the vessels in the subarachnoid space, penetrating arteries but not veins were surrounded by tracer. Correlative light and electron microscopy images indicated that this paravascular space was located outside of the endothelial layer in capillaries and just outside of the smooth muscle cells in arteries. In conclusion, the cerebrospinal fluid compartment, consisting of the subarachnoid space, cisterns, ventricles, and para-arteriolar spaces, forms a continuous and extensive network that surrounds and penetrates the rat brain, in which mixing may facilitate exchange between interstitial fluid and cerebrospinal fluid.
[Mh] Termos MeSH primário: Vasos Sanguíneos/diagnóstico por imagem
Encéfalo
Líquido Cefalorraquidiano/diagnóstico por imagem
Cisterna Magna
Imagem Tridimensional/métodos
[Mh] Termos MeSH secundário: Animais
Vasos Sanguíneos/ultraestrutura
Encéfalo/irrigação sanguínea
Encéfalo/diagnóstico por imagem
Encéfalo/ultraestrutura
Ventrículos Cerebrais/irrigação sanguínea
Ventrículos Cerebrais/diagnóstico por imagem
Ventrículos Cerebrais/ultraestrutura
Cisterna Magna/diagnóstico por imagem
Cisterna Magna/ultraestrutura
Dextranos
Endotélio Vascular/diagnóstico por imagem
Endotélio Vascular/ultraestrutura
Líquido Extracelular/diagnóstico por imagem
Masculino
Microscopia Confocal
Microscopia Eletrônica
Ratos Endogâmicos WKY
Espaço Subaracnóideo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dextrans)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160617
[St] Status:MEDLINE
[do] DOI:10.1177/0271678X16655550


  7 / 1951 MEDLINE  
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[PMID]:27594612
[Au] Autor:Lee EH; Park TS; Choi YS; Cho EH
[Ad] Endereço:Department of Pediatrics, Kyung Hee University School of Medicine, Seoul, Korea.
[Ti] Título:Familial aplasia cutis congenita associated with mega-cisterna magna.
[So] Source:Pediatr Int;58(10):1054-1056, 2016 Oct.
[Is] ISSN:1442-200X
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:Aplasia cutis congenita (ACC; MIM 107600) is a congenital skin disorder that manifests as localized absence of skin. Here we report a case of familial ACC and mega-cisterna magna. A female neonate was born with skin defects on the scalp. Brain magnetic resonance imaging demonstrated retrocerebellar space widening suggesting mega-cisterna magna. Her father also had a skin defect on the scalp at birth, and brain computed tomography of the father showed a cystic lesion over the right occipital lobe, similar to the patient's brain imaging. Karyotype 46,XX, t(6;18)(q23.2;q11.2) was identified on G-banded karyotype analysis of the patient and her father, after which whole exome sequencing was carried out, but this was thought to be a coincidental finding. This indicates that ACC may be associated with brain anomaly, although it is very rare.
[Mh] Termos MeSH primário: Cisterna Magna/diagnóstico por imagem
Displasia Ectodérmica/diagnóstico
Imagem por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Feminino
Seres Humanos
Recém-Nascido
Pele/diagnóstico por imagem
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160906
[St] Status:MEDLINE
[do] DOI:10.1111/ped.13041


  8 / 1951 MEDLINE  
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[PMID]:27581842
[Au] Autor:Djukic M; Spreer A; Lange P; Bunkowski S; Wiltfang J; Nau R
[Ad] Endereço:Department of Geriatrics, Evangelisches Krankenhaus Göttingen-Weende, Göttingen, Germany.
[Ti] Título:Small cisterno-lumbar gradient of phosphorylated Tau protein in geriatric patients with suspected normal pressure hydrocephalus.
[So] Source:Fluids Barriers CNS;13(1):15, 2016 Aug 31.
[Is] ISSN:2045-8118
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The composition of the cerebrospinal fluid (CSF) is not homogeneous, and concentrations of proteins from different origins diverge among ventricular, cisternal and lumbar CSF fractions. Concentrations of blood-derived proteins increase and of brain-derived proteins decrease from ventricular to lumbar fractions. We studied whether the origin of the CSF portion analysed may affect results in CSF analysis for dementia. METHODS: In 16 geriatric patients with suspected normal pressure hydrocephalus [age 82.5 (76/87) years; median (25th/75th percentile)] a lumbar spinal tap of 40 ml was performed. The CSF was sequentially collected in 8 fractions of 5 ml with the 1st fraction corresponding to lumbar CSF, the 8th to cisterna magna-near CSF. Fractions were analysed for total protein, albumin, Tau protein (Tau), phosphorylated Tau (pTau), Amyloid beta 1-42 (Aß1-42), Amyloid beta 1-40 (Aß1-40), and the Aß1-42/Aß1-40 ratio. RESULTS: The concentrations of total protein and albumin increased from cisternal to lumbar fractions due to diffusion-related accumulation from blood to CSF with significantly higher concentrations in fraction 1 compared to fraction 8. The concentrations of Tau showed a non-significant trend towards decreased values in lumbar samples, and pTau was slightly, but significantly decreased in the lumbar fraction 1 [26.5 (22.5/35.0) pg/ml] compared to the cistern-near fraction 8 [27.0 (24.2/36.3) pg/ml] (p = 0.02, Wilcoxon signed rank test). Aß1-42, Aß1-40, and the Aß1-42/Aß1-40 ratio remained almost constant. CONCLUSIONS: According to the flow-related diverging dynamics of blood-derived and brain-derived proteins in CSF, the concentrations of Tau and pTau tended to be lower in lumbar compared to cisternal CSF fractions after a spinal tap of 40 ml. The differences reached statistical significance for pTau only. The small differences will not affect clinical interpretation of markers of dementia in the vast majority of cases.
[Mh] Termos MeSH primário: Hidrocefalia de Pressão Normal/líquido cefalorraquidiano
Proteínas tau/líquido cefalorraquidiano
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Albuminas/líquido cefalorraquidiano
Peptídeos beta-Amiloides/líquido cefalorraquidiano
Biomarcadores/líquido cefalorraquidiano
Cisterna Magna
Feminino
Seres Humanos
Vértebras Lombares
Masculino
Fragmentos de Peptídeos/líquido cefalorraquidiano
Fosforilação
Punção Espinal
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Amyloid beta-Peptides); 0 (Biomarkers); 0 (MAPT protein, human); 0 (Peptide Fragments); 0 (amyloid beta-protein (1-40)); 0 (amyloid beta-protein (1-42)); 0 (tau Proteins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160902
[St] Status:MEDLINE
[do] DOI:10.1186/s12987-016-0039-9


  9 / 1951 MEDLINE  
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[PMID]:27349399
[Au] Autor:Tumturk A; Ulutabanca H; Gokoglu A; Oral S; Menku A; Kurtsoy A
[Ad] Endereço:Erciyes University, Medical Faculty, Department of Neurosurgery, Kayseri, Turkey.
[Ti] Título:The Results of the Surgical Treatment of Spontaneous Rhinorrhea via Craniotomy and the Contribution of CT Cisternography to the Detection of Exact Leakage Side of CSF.
[So] Source:Turk Neurosurg;26(5):699-703, 2016.
[Is] ISSN:1019-5149
[Cp] País de publicação:Turkey
[La] Idioma:eng
[Ab] Resumo:AIM: To share the results of conventional surgery in rhinorrhea and the contribution of computerized tomography (CT) cisternography to determination of the site of cerebrospinal fluid (CSF) leak. MATERIAL AND METHODS: Twelve cases treated for spontaneous rhinorrhea were included in this study. All the cases underwent cranial CT and magnetic resonance imaging (MRI). CT cisternography was performed in four patients whose bone defect or leakage site could not be detected by CT and MRI. In order to repair the defect, either the galea or galea together with collagen matrix was used and the procedure was supported with fibrin glue. RESULTS: In the cases, postoperative rhinorrhea was seen in neither the early nor the late follow up period. We observed no complications related to CT cisternography or craniotomy. The leakage area was successfully detected with CT cisternography when the other methods failed. CONCLUSION: Bone defect can usually be shown by means of CT. However, when bone-defect cannot be shown or the dura in the defective area is intact, CT cisternography is useful to show the CSF leak. Conventional surgery was very succesful in the treatment of spontaneous rhinorrhea but it was cosmetically problematic. In the patients both treated with galea and galea together with collagen matrix, the repair of the defect was successful.
[Mh] Termos MeSH primário: Rinorreia de Líquido Cefalorraquidiano/diagnóstico por imagem
Rinorreia de Líquido Cefalorraquidiano/cirurgia
Cisterna Magna/diagnóstico por imagem
Craniotomia/efeitos adversos
[Mh] Termos MeSH secundário: Adulto
Idoso
Vazamento de Líquido Cefalorraquidiano/complicações
Colágeno/uso terapêutico
Feminino
Adesivo Tecidual de Fibrina/uso terapêutico
Seres Humanos
Imagem por Ressonância Magnética
Masculino
Meia-Idade
Tomografia Computadorizada por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fibrin Tissue Adhesive); 9007-34-5 (Collagen)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160629
[St] Status:MEDLINE
[do] DOI:10.5137/1019-5149.JTN.13424-14.1


  10 / 1951 MEDLINE  
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[PMID]:27272672
[Au] Autor:Eddinger KA; Rondon ES; Shubayev VI; Grafe MR; Scadeng M; Hildebrand KR; Page LM; Malkmus SA; Steinauer JJ; Yaksh TL
[Ad] Endereço:From the Departments of Anesthesiology (K.A.E., E.S.R., V.I.S., S.A.M., J.J.S., T.L.Y.) and Radiology (M.S.), University of California, San Diego, La Jolla, California; Departamento de Medicina Veterinária, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil (E.S.R.); Department of Anesthesiology, Veterans Affairs San Diego Healthcare System, La Jolla, California (V.I.S.); Department of Pathology, Oregon Health Sciences University, Portland, Oregon (M.R.G.); and Departments of Global Research and Neuromodulation, Medtronic, Inc., Minneapolis, Minnesota (K.R.H., L.M.P.).
[Ti] Título:Intrathecal Catheterization and Drug Delivery in Guinea Pigs: A Small-animal Model for Morphine-evoked Granuloma Formation.
[So] Source:Anesthesiology;125(2):378-94, 2016 Aug.
[Is] ISSN:1528-1175
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Intrathecal infusion of opioids in dogs, sheep, and humans produces local space-occupying masses. To develop a small-animal model, the authors examined effects of intrathecal catheterization and morphine infusion in guinea pigs. METHODS: Under isoflurane, polyethylene or polyurethane catheters were advanced from the cisterna magna to the lumbar enlargement. Drugs were delivered as a bolus through the externalized catheter or continuously by subcutaneous minipumps. Hind paw withdrawal to a thermal stimulus was assessed. Spinal histopathology was systematically assessed in a blinded fashion. To assist in determining catheter placement, ex vivo images were obtained using magnetic resonance imaging in several animals. Canine spinal tissue from previous intrathecal morphine studies was analyzed in parallel. RESULTS: (1) Polyethylene (n = 30) and polyurethane (n = 25) catheters were implanted in the lumbar intrathecal space. (2) Bolus intrathecal morphine produced a dose-dependent (20 to 40 µg/10 µl) increase in thermal escape latencies. (3) Absent infusion, a catheter-associated distortion of the spinal cord and a fibrotic investment were noted along the catheter tract (polyethylene > polyurethane). (4) Intrathecal morphine infusion (25 mg/ml/0.5 µl/h for 14 days) resulted in intrathecal masses (fibroblasts, interspersed collagen, lymphocytes, and macrophages) arising from meninges proximal to the catheter tip in both polyethylene- and polyurethane-catheterized animals. This closely resembles mass histopathology from intrathecal morphine canine studies. CONCLUSIONS: Continuous intrathecal infusion of morphine leads to pericatheter masses that morphologically resemble those observed in dogs and humans. This small-animal model may be useful for studying spinal drug toxicology in general and the biology of intrathecal granuloma formation in particular.
[Mh] Termos MeSH primário: Analgésicos Opioides/efeitos adversos
Cateterismo/métodos
Sistemas de Liberação de Medicamentos/métodos
Granuloma/induzido quimicamente
Injeções Espinhais/métodos
Morfina/efeitos adversos
Doenças da Medula Espinal/induzido quimicamente
[Mh] Termos MeSH secundário: Animais
Cateteres
Cisterna Magna
Modelos Animais de Doenças
Cães
Relação Dose-Resposta a Droga
Granuloma/patologia
Cobaias
Imagem por Ressonância Magnética
Masculino
Meninges/patologia
Polietileno
Poliuretanos
Doenças da Medula Espinal/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics, Opioid); 0 (Polyurethanes); 76I7G6D29C (Morphine); 9002-88-4 (Polyethylene)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170602
[Lr] Data última revisão:
170602
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1097/ALN.0000000000001166



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